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G Schmalz, L Berisha, H Wendorff, F Widmer, A Marcinkowski, H Teschler, U Sommerwerck, R Haak, O Kollmar, D Ziebolz
BACKGROUND: Aim of this study was to investigate the association of the time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected periodontal pathogenic bacteria of immunosuppressed patients after solid organ transplantation (SOT). MATERIAL AND METHODS: 169 Patients after SOT (lung, liver or kidney) were included and divided into subgroups according their time under (0-1, 1-3, 3-6, 6-10 and >10 years) and form of immunosuppression (Tacrolimus, Cyclosporine, Mycophenolate, Glucocorticoids, Sirolimus and monotherapy vs...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
Heloisa N Pantaroto, Antonio P Ricomini-Filho, Martinna M Bertolini, José H D Silva, Nilton F Azevedo Neto, Cortino Sukotjo, Elidiane C Rangel, Valentim A R Barão
OBJECTIVE: Titanium dioxide (TiO2 ) incorporation in biomaterials is a promising technology due to its photocatalytic and antibacterial activities. However, the antibacterial potential of different TiO2 crystalline structures on a multispecies oral biofilm remains unknown. We hypothesized that the different crystalline TiO2 phases present different photocatalytic and antibacterial activities. METHODS: Three crystalline TiO2 films were deposited by magnetron sputtering on commercially pure titanium (cpTi), in order to obtain four groups: (1) machined cpTi (control); (2) A-TiO2 (anatase); (3) M-TiO2 (mixture of anatase and rutile); (4) R-TiO2 (rutile)...
April 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Jenn-Ren Hsiao, Chan-Chi Chang, Wei-Ting Lee, Cheng-Chih Huang, Chun-Yen Ou, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
Poor oral hygiene may lead to overgrowth of pathogenic oral bacteria, which may induce chronic inflammation to promote the oncogenesis of oral squamous cell carcinoma (OSCC). This study investigated the association between oral bacterial profile and OSCC risk in a case-control study of 138 OSCC cases and 151 controls (88 cases and 90 controls for the discovery group and 50 cases and 61 controls for the validation group). Oral bacterial profiles were characterized by targeted sequencing of the 16S rRNA gene...
April 13, 2018: Carcinogenesis
Laura Garcia, Kaori Ito
Case: Lemierre's syndrome is a rare clinical condition that is characterized by infected internal jugular vein thrombosis with metastatic septicemia. The most common causative agent is Fusobacterium necrophorum . A previously healthy 37-year-old woman presented to our emergency department with nausea, vomiting, and diarrhea. She was admitted to the general practice unit with a diagnosis of acute pancreatitis then was subsequently transferred to the intensive care unit due to shock. Physical examination revealed tenderness on right side of the neck...
April 2018: Acute Medicine & Surgery
Alanna Dubrovsky, Christopher L Kitts
A 20-year-old female was diagnosed with ulcerative colitis (UC) at age 14 and primary sclerosing cholangitis (PSC) at age 16. The PSC was successfully treated with high doses of oral vancomycin; however, the UC was more difficult to manage. After many drug treatments failed to treat the UC, the patient began following the specific carbohydrate diet (SCD). This report documents fecal microbiome changes resulting from following the SCD for two weeks. The DNA extracted from fecal samples was subjected to 16S rRNA gene sequencing to quantify bacterial species abundance...
February 9, 2018: Curēus
Zhenwei Dai, Olabisi Oluwabukola Coker, Geicho Nakatsu, William K K Wu, Liuyang Zhao, Zigui Chen, Francis K L Chan, Karsten Kristiansen, Joseph J Y Sung, Sunny Hei Wong, Jun Yu
BACKGROUND: Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort the structure of microbial dysbiosis in CRC and lead to inconsistent results among studies. In this regard, our study targeted at exploring changes in gut microbiota that are universal across populations at species level...
April 11, 2018: Microbiome
Cengiz Demir, Recep Keşli
The aim of this study was to identify gram-negative anaerobic bacilli isolated from various clinical specimens that were obtained from patients with suspected anaerobic infections and to determine the antibiotic resistance profiles by using the antibiotic concentration gradient method. The study was performed in Afyon Kocatepe University Ahmet Necdet Sezer Research and Practice Hospital, Medical Microbiology Laboratory between 1 November 2014 and 30 October 2015. Two hundred and seventyeight clinical specimens accepted for anaerobic culture were enrolled in the study...
January 2018: Mikrobiyoloji Bülteni
Marie-Caroline Ploton, Marion Caseris, Christelle Jost, Yoann Picard, Jean Gaschignard, Charlotte Pierron, Suzy Canivez, Roxanne Le Dalour, Michael Bendavid, Agnès Carol, Philippe Bidet, Stéphane Bonacorsi
We retrospectively report four cases from two hospitals of nonpneumococcal pleural empyema with a likely false-positive result on the pneumococcal antigen test BinaxNOW (PATB) (Alere) performed in pleural fluid samples in patients with aspiration pneumonia risk factors. To determine whether the positive reaction was due to cross-reactivity, we separately tested the isolates from the pleural fluid samples, along with collection and reference strains. All patients had polymicrobial aerobic and anaerobic positive cultures, including Parvimonas micra in every case...
April 2018: Chest
Dries Vandeweyer, Enya Wynants, Sam Crauwels, Christel Verreth, Nikolaas Viaene, Johan Claes, Bart Lievens, Leen Van Campenhout
In this study, the microbiota during industrial rearing, processing, and storage of the edible tropical house cricket, Gryllodes sigillatus , was investigated. To this end, samples were analyzed of the cricket feed, before feeding as well as taken from the cages, and the crickets during rearing, after harvest, and after processing into frozen, oven-dried, and smoked and subsequently oven-dried end products. Although the feed contained lower microbial numbers than the crickets, both were dominated by the same species-level operational taxonomic units as determined by Illumina Miseq sequencing...
April 6, 2018: Applied and Environmental Microbiology
Leonardo A Guevarra, Andrea Claudine F Afable, Patricia Joyce O Belza, Karen Joy S Dy, Scott Justin Q Lee, Teresa T Sy-Ortin, Pia Marie S P Albano
Background: The role of Fusobacterium nucleatum Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of natural killer (NK) cells against cancer cells, thus, allowing proliferation of the latter eventually leading to tumor growth. The aim of the study was to identify the immunogenicity of a peptide mimotope of the Fap2 protein and to determine the reactivity of colorectal cancer patients' sera against the mimotope...
2018: Infectious Agents and Cancer
So Y Lee, Si Y Lee
As soon as they are exposed to the environment, cosmetics become contaminated with microorganisms, and this contamination accumulates with increased use. In this study, we employed pyrosequencing to investigate the diversity of bacteria found on lipstick. Bacterial DNA was extracted from 20 lipstick samples and mixed in equal ratios for pyrosequencing analysis. As a result, 105 bacterial genera were detected, four of which ( Leifsonia , Methylobacterium , Streptococcus , and Haemophilus ) were predominant in 92% of the 19,863 total sequence reads...
July 2017: Journal of Cosmetic Science
Vasanthapriya Subramaniyam, Akiko Saito, Katsutoshi Tokushige
An oral infection harboring Fusobacterium species can gain entrance to the liver via hematogenous spread in the form of septic embolus, and can thereby cause abscesses. Such spread, described as Lemierre syndrome, is life threatening. We present such a case history of a man in his mid-40s, who presented with infection and Fusobacterium liver abscess with an acute fulminant disease course. The initial diagnosis was arrived at by ultrasound imaging and blood investigations. He was treated with antibiotics, ultrasound-guided liver abscess drainage, and extraction of the infected molar tooth...
April 3, 2018: Journal of Medical Ultrasonics
S Farooq, S A Wani, M N Hassan, S Aalamgeer, Z A Kashoo, S N Magray, M A Bhat
The objective of this study was to determine the prevalence and identification of leukotoxin gene, lktA, variant strains of Fusobacterium necrophorum in the footrot lesions of sheep. The detection of F. necrophorum was carried out by PCR targeting the lktA gene fragment and identification of lktA variant strains was done by PCR-single stranded conformational polymorphism (PCR-SSCP) and gene sequencing. Of the 450 swabs collected from footrot lesions of sheep, 117 were lktA-positive for F. necrophorum. Of the 50 swabs collected from apparently asymptomatic sheep, only one was lktA-positive for F...
March 26, 2018: Anaerobe
Miri Gelbart, Efraim Bilavski, Gabriel Chodick, Eyal Raveh, Itzhak Levy, Liat Ashkenazi-Hoffnung
BACKGROUND: Recent reports have reported an increase in the incidence of acute mastoiditis due to Fusobacterium necrophorum. However, the crude incidence and the specific clinical and laboratory characteristics of F.necrophorum mastoiditis in children have not been described. Our aim was to describe these features, in order to identify high-risk patients. METHODS: The electronic medical records of all children with acute mastoiditis at a tertiary medical center between 7/2011 and 12/2015 were analyzed...
March 24, 2018: Pediatric Infectious Disease Journal
M K Lesiów, U K Komarnicka, K Stokowa-Sołtys, K Rolka, A Łęgowska, N Ptaszyńska, R Wieczorek, A Kyzioł, M Jeżowska-Bojczuk
The copper(ii) ion binding of the Ac-KGHGNG-NH2 and Ac-PTVHNE-NH2 fragments of FomA adhesin from Fusobacterium nucleatum was studied using potentiometry, UV-Vis, CD, EPR and DFT techniques. The coordination pattern was described in a wide range of pH values. Ligands begin interactions with metal ions using imidazole nitrogen. At pH 6.8 (a value typical of the large intestine environment), the metal ion was coordinated by the 3N donor atoms {Nim, 2 × N-amide} in both cases. However, the copper(ii) ion was bound more effectively by the Ac-PTVHNE-NH2 peptide...
March 29, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Federico Cunha, Soo Jin Jeon, Rodolfo Daetz, Achilles Vieira-Neto, Jimena Laporta, K Casey Jeong, Anthony F Barbet, Carlos A Risco, Klibs N Galvão
Metritis is caused by polymicrobial infection; however, recent metagenomic work challenges the importance of known pathogens such as Escherichia coli and Trueperella pyogenes while identifying potential new pathogens such as Bacteroides pyogenes, Porphyromonas levii and Helcococcus ovis. This study aims to quantify known and emerging uterine pathogens, and to evaluate their association with metritis and fever in dairy cows. Metritis was diagnosed at 6 ± 2 days postpartum, a uterine swab was collected and rectal temperature was measured...
March 16, 2018: Theriogenology
Qusai Aljarrah, Yara Khazaleh, Mooath Al-Jarrah, Jordan W Oldbury, Ahmad K Abou-Foul
INTRODUCTION: Lemierre's syndrome (LS) is a rare and life-threatening condition characterized by suppurative thrombophlebitis of the internal jugular vein (IJV), and a history of head and neck (H&N) sepsis. LS is usually caused by Fusobacterium necrophorum, which is part of the normal flora in the oro-pharynx, and the digestive and urogenital tracts. We here report the first case of LS following perianal sepsis. PRESENTATION OF CASE: A 60-year-old man with a painful left neck swelling, dysphagia and worsening sepsis was referred from a peripheral unit where he had an incision and drainage of a perianal abscess a week earlier...
March 16, 2018: International Journal of Surgery Case Reports
Christina Parvinder Kaur, Jamuna Vadivelu, Samudi Chandramathi
The 2016 Global Burden of Disease report by WHO revealed that diseases of the gastrointestinal tract had one of the highest incidence rates worldwide. The plethora of factors that contribute to the development of gastrointestinal tract (GIT) related illnesses can be divided into genetic, environmental and lifestyle factors. Apart from that, the role that infectious agents play in the development of GIT diseases has piqued the interest of researchers worldwide. The human gut harbours approximately 101 to 1012 cfu/ml bacteria in it with increasing concentration towards the lower GIT...
March 24, 2018: Journal of Digestive Diseases
Thais M Duque, Maira Prado, Daniel R Herrera, Brenda P F A Gomes
OBJECTIVE: The aim of the present study was to investigate the effects of a calcium hydroxide-based intracanal medication (ICM) on periodontal and endodontic infectious/inflammatory contents and on periodontal clinical parameters in teeth with primary periodontal lesion and secondary endodontic involvement. MATERIALS AND METHODS: Ten patients with abnormal pulp test results and deep probing depth derived from primary periodontal disease with secondary endodontic involvement were included...
March 23, 2018: Clinical Oral Investigations
Girija Jaiman, Prathibha Anand Nayak, Sanu Sharma, Kiran Nagpal
Background: Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established. Hence, an attempt has been made in this study to evaluate the relationship between the preeclampsia and maternal periodontal disease. Materials and Methods: The case-control study comprised of thirty pregnant women distributed equally in the case (preeclampsia) and control (healthy) group...
January 2018: Journal of Indian Society of Periodontology
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