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Muhammad Bader Hammami, Elizabeth M Noonan, Anuj Chhaparia, Feras Al Khatib, Juri Bassuner, Christine Hachem
Pyogenic liver abscesses (PLA) develop from the spread of infection through the portal circulation, biliary infections or arterial hematogenous seeding in the setting of systemic infections. PLA are often poly-microbial and are uncommonly reported to be due to anaerobic species. We report the case of a previously healthy, immunocompetent 63-year-old man with hepatic abscesses as a result of Fusobacterium nucleatum periodontal disease. In addition, a systemic review of the literature is performed. Fusobacterium is a very rare cause of PLA in immunocompetent hosts with only a handful of cases reported in the literature...
June 2018: Gastroenterology Research
Songhe Guo, Linfang Li, Banglao Xu, Manghui Li, Qiuyao Zeng, Han Xiao, Ying Xue, Yixian Wu, Yidan Wang, Wanli Liu, Ge Zhang
BACKGROUND: Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). We evaluated the utility of fecal bacterial biomarker candidates identified by our 16S rDNA sequencing analysis for CRC diagnosis. METHODS: We measured the relative abundance of Fusobacterium nucleatum ( Fn ), Faecalibacterium prausnitzii ( Fp ), Bifidobacterium ( Bb ), and Lactobacillus ( Lb ) by quantitative PCR in fecal samples from 2 cohorts of 903 individuals. We evaluated and validated the diagnostic performance of these microbial ratios and investigated the antagonistic effect of Fn against 3 different indicator stains...
June 18, 2018: Clinical Chemistry
Nicholas C McDonald, Robert L White
Accumulation of succinate as a fermentation product of Fusobacterium varium was enhanced when the anaerobic bacterium was grown on complex peptone medium supplemented with fumarate. Residual substrates and fermentation products were determined by proton NMR spectroscopy. Cells collected from the fumarate-supplemented medium (8-10 h after inoculation) supported the conversion of fumarate to succinate when suspended with fumarate and a co-substrate (glucose, sorbitol, or glycerol). Succinate production was limited by the availability of fumarate or reducing equivalents supplied by catabolism of a co-substrate via the Embden-Meyerhof-Parnas (EMP) pathway...
June 18, 2018: Applied Biochemistry and Biotechnology
L Virto, H J Haugen, P Fernández-Mateos, P Cano, J González, V Jiménez-Ortega, A I Esquifino, M Sanz
BACKGROUND AND OBJECTIVE: Melatonin deficiency has been associated with obesity and systemic inflammation. This study aims to evaluate whether melatonin could interfere with the mechanisms of co-morbidity linking obesity and periodontitis. MATERIAL AND METHODS: Twenty-eight male Wistar rats were randomly divided in 4 groups: control group (Con) (fed with standard diet); high-fat diet group (HFD) (fed with a diet containing 35.2% fat); Con group with induced periodontitis (Con-Perio) and HFD group with induced periodontitis (HFD-Perio)...
June 14, 2018: Journal of Periodontal Research
Ahmed O Alomair, Ibrahim Masoodi, Essam J Alyamani, Abed A Allehibi, Adel N Qutub, Khalid N Alsayari, Musaad A Altammami, Ali S Alshanqeeti
Background and Aim: Because genetic and geographic variations in intestinal microbiota are known to exist, the focus of this study was to establish an estimation of microbiota in colorectal cancer (CRC) patients in Saudi Arabia by means of metagenomic studies. Methods: From July 2010 to November 2012, colorectal cancer patients attending our hospital were enrolled for the metagenomic studies. All underwent clinical, endoscopic, and histological assessment. Mucosal microbiota samples were collected from each patient by jet-flushing colonic mucosa with distilled water at unified segments of the colon, followed by aspiration, during colonoscopy...
2018: Gastroenterology Research and Practice
Franco Cavalla, Claudia Cristina Biguetti, Jessica Lima Melchiades, Andre Pantenuci Tabanez, Michelle de Campos Soriani Azevedo, Ana Paula Favaro Trombone, Marcelo Faveri, Magda Feres, Gustavo Pompermaier Garlet
Chronic periodontitis is the most prevalent form of inflammatory destructive bone disease and has been affecting humans since antiquity. Evidence suggest that genetic factors can highly influence periodontitis risk, modulating disease elements such as the susceptibility to microbial colonization and the nature of subsequent host-microbe interaction. Several single-nucleotide polymorphisms (SNPs) have been associated with the occurrence of periodontitis, but the full range of genetic influence in periodontitis outcomes remains to be determined...
May 23, 2018: Genes
Grace Faith Chao, Sameer Hirji, Scott Alan Shikora
Sleeve gastrectomy is a relatively newer bariatric surgical procedure and has become the most common of all bariatric surgeries performed. Complication rates reported with sleeve gastrectomies are relatively low and are generally due to staple line leaks, hemorrhage, or sleeve stricture. Portal vein thrombosis is an uncommon but potentially dangerous complication. We present a case of a 21-year-old woman who developed thrombosis of the portal, splenic, and right common iliac veins that then resulted in multifocal brain abscesses from presumed Fusobacterium septic emboli following an uncomplicated laparoscopic sleeve gastrectomy...
March 2018: Journal of Radiology Case Reports
C De Witte, R Ducatelle, F Haesebrouck
Ulceration of the non-glandular part of the stomach is a common disease entity of pigs worldwide, with prevalences of up to 93%. It may result in decreased daily weight gain, decreased feed intake and sudden death, thus leading to significant economic losses, as well as animal welfare issues. The aetiology is multifactorial. Diet particle size, management and infectious agents have been hypothesised to be involved. The exact mechanism behind porcine gastric ulceration is, however, not completely clear. The aim of this article is to provide an overview of the role of infectious agents in the development of porcine gastric ulceration...
June 2018: Veterinary Journal
S Waqas, C Bannan, A Fe Talento, D Byrne, S O'Donnell, S Clarke, C Merry
We describe a patient presenting with constitutional symptoms, poor oral hygiene and leg swelling who was diagnosed with Fusobacterium nucleatum osteomyelitis of femur and empyema. Long bone osteomyelitis is rarely caused by this microorganism. This unusual case was successfully managed with drainage and antimicrobial therapy.
January 10, 2018: Irish Medical Journal
Xiao-Ling Tang, Xiao Liu, Hui Suo, Zhi-Chao Wang, Ren-Chao Zheng, Yu-Guo Zheng
The tyrosine phenol lyase (TPL) catalyzed synthesis of L-DOPA was regarded as one of the most economic route for L-DOPA synthesis. In our previous study, a novel TPL from Fusobacterium nucleatum (Fn-TPL) was exploited for efficient biosynthesis of L-DOPA. However, the catalytic efficiency decreased when the reaction system expanded from 100 mL to 1 L. As such, the bioprocess for scale-up production of L-DOPA was developed in this study. To increase the stability of substrate and product, as well as decrease the by-product formation, the optimum temperature and pH were determined to be 15 °C and pH 8...
June 5, 2018: Bioprocess and Biosystems Engineering
Kazuki Okamoto, Tomohiro Watanabe, Yoriaki Komeda, Ayana Okamoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Satoru Hagiwara, Toshiharu Sakurai, Tomonori Tanaka, Hiroki Sakamoto, Kiyoshige Fujimoto, Naoshi Nishida, Masatoshi Kudo
Cap polyposis is a rare gastrointestinal disease characterized by multiple inflammatory polyps located between the distal colon and the rectum. Despite the lack of clarity regarding its pathogenesis, mucosal prolapse, chronic inflammatory responses, and Helicobacter pylori infection are considered key contributors to the development of this disease entity. Although it is now generally accepted that dysbiosis of gut microbiota is associated with intestinal and extra-intestinal diseases, alterations of intestinal microbiota have been poorly defined in cap polyposis...
2018: Frontiers in Immunology
Jae M Shin, Ting Luo, Kyu Han Lee, Diogo Guerreiro, Tatiana M Botero, Neville J McDonald, Alexander H Rickard
INTRODUCTION: Biofilms are present in more than 70% of endodontically diseased teeth. Through the advancements in the next-generation sequencing (NGS) technologies, microbiome research has granted a deeper analysis of the microbial communities living in human hosts. Here, we reviewed previous studies that used NGS to profile the microbial communities of root canals. METHODS: A total of 12 peer-reviewed articles from PubMed were identified and critically reviewed...
June 1, 2018: Journal of Endodontics
Kayoko Hayakawa, Maki Nagashima, Kaichi Ohta, Norio Ohmagari, Niro Tayama
Fusobacterium necrophorum has recently been suggested to be associated with tonsillopharyngitis, peritonsillar abscess, and recurrent tonsillitis. Among the 2 subspecies of F. necrophorum, subsp. funduliforme is known to be a major human pathogen. To better understand the epidemiology of F. necrophorum subsp. funduliforme (FNSF), we studied the prevalence of FNSF in the tonsils of patients undergoing elective tonsillectomy (TE) for different indications. Adult patients who underwent elective TE from October 2014 to November 2015 were included...
May 31, 2018: Japanese Journal of Infectious Diseases
Kai Bao, Nagihan Bostanci, Thomas Thurnheer, Jonas Grossmann, Witold E Wolski, Bernard Thay, Georgios N Belibasakis, Jan Oscarsson
Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. An important virulence property of A. actinomycetemcomitans is its ability to form tenacious biofilms that can attach to abiotic as well as biotic surfaces. The histone-like (H-NS) family of nucleoid-structuring proteins act as transcriptional silencers in many Gram-negative bacteria. To evaluate the role of H-NS in A. actinomycetemcomitans , hns mutant derivatives of serotype a strain D7S were generated...
2018: NPJ Biofilms and Microbiomes
Judy Ibrahim, Muhammad Bassel Noureddin, Ali Lootah, Aisha Al Khalidi, Ghassan Ghatasheh, Hossam Al Tatari
Lemierre's syndrome (LS) is a serious rare complication of oropharyngeal infections. It is characterized by thrombosis of internal jugular vein that rapidly progresses into sepsis and is typically caused by anaerobes. Most of the reported cases have been linked to Fusobacterium necrophorum ; however, there are a handful of reported cases due to aerobes. It is primarily the disease of healthy young adults and can present in school-aged children. The early recognition and treatment of this complication results in resolution of the illness; nevertheless, there have been some concerns about chronic venous insufficiency as a long-term complication...
2018: Case Reports in Pediatrics
Kaori Tosaki, Hirokazu Kojima, Shunsuke Akama, Yoshihiro Ootake, Kyoichi Inoue, Ken Katsuda, Tomoyuki Shibahara
An underweight 10-month-old Holstein heifer presented with anorexia and ananastasia and was euthanized. Postmortem examination revealed extensive ulceration in the esophagus, tongue, and omasum. Histopathological examination revealed severe necrotic esophagitis, glossitis, and omasitis. Many Gram-negative bacilli were detected throughout the necrotic area in the digestive tract; these were identified as Pseudomonas aeruginosa on the basis of isolation tests, molecular examinations, and immunohistochemistry...
May 25, 2018: Journal of Veterinary Medical Science
Turky AlSaeed, Ali Nosrat, Mary Anne Melo, Ping Wang, Elaine Romberg, Huakun Xu, Ashraf F Fouad
INTRODUCTION: The optimal concentration for the use of endodontic topical antibiotics is not known. The aims of this study were to determine the minimum bactericidal concentrations (MBCs) and minimum inhibitory concentrations (MICs) of metronidazole, ciprofloxacin, minocycline, Augmentin (GlaxoSmithKline, Research Triangle Park, NC), and tigecycline against common endodontic pathogens and to evaluate ex vivo the antibacterial efficacy and discoloration effect of triple antibiotic paste (TAP), Augmentin, and tigecycline at different concentrations using a slow-release hydrogel scaffold...
May 23, 2018: Journal of Endodontics
Rubén Abraham Domínguez-Pérez, Rocio De la Torre-Luna, Mariana Ahumada-Cantillano, Ma Soledad Vázquez-Garcidueñas, Rosa Martha Pérez-Serrano, Rita Elizabeth Martínez-Martínez, Ana Laura Guillén-Nepita
OBJECTIVES: To identify the prevalence of genes encoding resistance to three groups of antibiotics in root canals with primary infection or post-treatment disease. METHODS: Sixty four subjects who needed root canal treatment because of primary infection or post-treatment disease were enrolled in the present cross-sectional analytic study. Root canal samples were obtained, and DNA isolated. Specific primers for six antibiotic resistance genes and seven bacterial taxa (five genera and two species) were used...
May 22, 2018: Journal of Global Antimicrobial Resistance
C Y Vincent Ngu, J Rohaizam, Y H Jong
Lemierre's syndrome is a systemic complication commonly caused by oropharyngeal infection by Fusobacterium species, which manifests itself as an internal jugular vein thrombosis formation. It is a rare occurrence nowadays with the availability of broad spectrum antibiotics for treatment. Most cases in the literature presented with a life-threatening condition. We are reporting a case of Lemierre's syndrome that presented with persistent neck pain and swelling, initially diagnosed as cervical lymphadenitis.
2018: Malaysian Family Physician
Masaya Yasutake, Atsushi Kotera, Susumu Yamaguchi, Kazuhiko Suyama
We report a case of cerebellum abscess due to <i>Fusobacterium nucleatum</i>(<i>F. nucleatum</i>) in a 60-year-old man. He was admitted to our hospital complaining of headache and dizziness. On admission, he was lucid with the following vital data:blood pressure, 136/89 mmHg;heart rate, 65 beats/min;body temperature, 37.0℃;and oxygen saturation, 100%. He had a moderate headache and could not walk straight. In general, there were no abnormal findings except for his poor dental hygiene...
May 2018: No Shinkei Geka. Neurological Surgery
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