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https://www.readbyqxmd.com/read/28214091/multidonor-intensive-faecal-microbiota-transplantation-for-active-ulcerative-colitis-a-randomised-placebo-controlled-trial
#1
Sudarshan Paramsothy, Michael A Kamm, Nadeem O Kaakoush, Alissa J Walsh, Johan van den Bogaerde, Douglas Samuel, Rupert W L Leong, Susan Connor, Watson Ng, Ramesh Paramsothy, Wei Xuan, Enmoore Lin, Hazel M Mitchell, Thomas J Borody
BACKGROUND: The intestinal microbiota is implicated in the pathogenesis of ulcerative colitis. Faecal microbiota transplantation is a novel form of therapeutic microbial manipulation, but its efficacy in ulcerative colitis is uncertain. We aimed to establish the efficacy of intensive-dosing, multidonor, faecal microbiota transplantation in active ulcerative colitis. METHODS: We conducted a multicentre, double-blind, randomised, placebo-controlled trial at three hospitals in Australia...
February 14, 2017: Lancet
https://www.readbyqxmd.com/read/28199859/structure-of-the-lps-o-chain-from-fusobacterium-nucleatum-strain-10953-containing-sialic-acid
#2
Evgeny Vinogradov, Frank St Michael, Kiyonobu Homma, Ashu Sharma, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. Recently, it has been gaining attention as a potential causative agent for colorectal cancer and is strongly linked with pregnancy complications including pre-term and still births. Little is known about virulence factors of this organism and thus we have initiated studies to examine the bacterial surface glycochemistry. Consistent with a recent paper suggesting that F. nucleatum strain 10593 can synthesize sialic acid, a staining technique identified sialic acid on the bacterial surface...
January 28, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28199766/dysbiosis-of-oral-buccal-mucosa-microbiota-in-patients-with-oral-lichen-planus
#3
Yuan He, Diping Gong, Cong Shi, Fangyang Shao, Jiahao Shi, Jian Fei
OBJECTIVE: The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control. SUBJECTS AND METHODS: Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non-erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S rDNA region were amplified and sequenced by high-throughput 454 pyrosequencing. RESULTS: 94.26% of the total buccal bacteria were classified into 15 abundant genera...
February 15, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28198980/influence-of-glycemic-control-on-the-levels-of-subgingival-periodontal-pathogens-in-patients-with-generalized-chronic-periodontitis-and-type-2-diabetes
#4
Tamires Szeremeske Miranda, Magda Feres, Belén Retamal-Valdés, Paula Juliana Perez-Chaparro, Suellen Silva Maciel, Poliana Mendes Duarte
Objective: This study evaluated the influence of glycemic control on the levels and frequency of subgingival periodontal pathogens in patients with type 2 diabetes mellitus (DM) and generalized chronic periodontitis (ChP). Material and Methods: Fifty-six patients with generalized ChP and type 2 DM were assigned according to the levels of glycated hemoglobin (HbA1c) into one of the following groups: HbA1c<8% (n=28) or HbA1c≥8% (n=28). Three subgingival biofilm samples from sites with probing depth (PD)<5 mm and three samples from sites with PD≥5 mm were analyzed by quantitative Polymerase Chain Reaction (PCR) for the presence and levels of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Eubacterium nodatum, Parvimona micra, Fusobacterium nucleatum ssp...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28193569/analysis-of-the-expression-of-nlrp3-and-aim2-in-periapical-lesions-with-apical-periodontitis-and-microbial-analysis-outside-the-apical-segment-of-teeth
#5
Shujun Ran, Bin Liu, Shensheng Gu, Zhe Sun, Jingping Liang
OBJECTIVE: To detect the distribution and expression levels of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and the absent in Melanoma 2 (AIM2) inflammasomes in periapical lesions and to analyse the possible microbial stimuli outside of teeth. DESIGN: The distribution of NLRP3 and AIM2 inflammasomes in sixteen periapical lesions was investigated by immunohistochemistry. Meanwhile, the relative gene expression levels of NLRP3 and AIM2 in sixteen periapical lesions and three health periodontal tissue were quantified by real-time polymerase chain reaction (PCR)...
February 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28192256/response-of-gut-health-and-microbiota-to-sulfide-exposure-in-pacific-white-shrimp-litopenaeus-vannamei
#6
Yantong Suo, Erchao Li, Tongyu Li, Yongyi Jia, Jian G Qin, Zhimin Gu, Liqiao Chen
Sulfide is a natural and widely distributed toxicant. It can be commonly found on the interface between water and sediment in the aquatic environment. The Pacific white shrimp Litopenaeus vannamei starts life in the benthic zone soon after the mysis stage, an early stage of post larvae. Therefore, L. vannamei is inevitably affected by exposure to sulfide released from pond sediment. This study explored the toxicant effect of different concentrations of sulfide on the intestinal health and microbiota of Pacific white shrimp by monitoring the change of expression of inflammatory, immune related cytokines, and the structure of the intestinal microbiota...
February 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28186709/in-vitro-evaluation-of-the-biological-compatibility-and-antibacterial-activity-of-a-bone-substitute-material-consisting-of-silver-doped-hydroxyapatite-and-bio-oss-%C3%A2
#7
Jingjue Gong, Lei Yang, Qi He, Ting Jiao
This study evaluated biological compatibility and antibacterial activity of a bone substitute material consisting of silver-doped hydroxyapatite (AgHA) and Bio-Oss(®) with different mixture ratios in vitro and investigated its antibacterial mechanism. AgHA was synthesized by a chemical precipitation method. After characterization, AgHA was mixed with Bio-Oss(®) at three ratios: 1:1, 1:2, and 1:4 by weight. Then, Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were used to test the antibacterial activity of the mixture...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28173636/identification-and-characterization-of-a-novel-fusobacterium-nucleatum-adhesin-involved-in-physical-interaction-and-biofilm-formation-with-streptococcus-gordonii
#8
Bruno P Lima, Wenyuan Shi, Renate Lux
To successfully colonize the oral cavity, bacteria must directly or indirectly adhere to available oral surfaces. Fusobacterium nucleatum plays an important role in oral biofilm community development due to its broad adherence abilities, serving as a bridge between members of the oral biofilm that cannot directly bind to each other. In our efforts to characterize the molecular mechanisms utilized by F. nucleatum to physically bind to key members of the oral community, we investigated the involvement of F. nucleatum outer membrane proteins in its ability to bind to the pioneer biofilm colonizer, Streptococcus gordonii...
February 7, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28163049/fusobacterium-nucleatum-bacteremia-presenting-with-portal-vein-thrombosis-an-abdominal-lemierre-syndrome
#9
Joseph A Moore, Siayareh Rambally
No abstract text is available yet for this article.
February 2, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28161185/the-bovine-colostrum-microbiome-and-its-association-with-clinical-mastitis
#10
Svetlana F Lima, Andre G V Teixeira, Fabio S Lima, Erika K Ganda, Catherine H Higgins, Georgios Oikonomou, Rodrigo C Bicalho
In an effort to characterize colostrum microbial diversity and its potential associations with early-lactation clinical mastitis, we used high-throughput sequencing of the 16S rRNA gene to investigate the bovine colostrum microbiome. A prospective observational study was conducted that included 70 Holstein cows; colostrum samples were collected from all 4 mammary gland quarters. Colostrum samples were categorized according to whether the quarter was diagnosed (CMC) or not diagnosed (NCMC) with clinical mastitis during the first 30 d postpartum...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28159588/bacterial-diversity-in-medication-related-osteonecrosis-of-the-jaw
#11
Fredrik Hallmer, Tore Bjørnland, Gunilla Andersson, Jonas P Becktor, Anne K Kristoffersen, Morten Enersen
OBJECTIVE: The aim was to study the association between microflora and medication-related osteonecrosis of the jaw (MRONJ) by using culture-independent molecular techniques to detect bacteria in necrotic bone lesions. STUDY DESIGN: Included were 18 consecutive patients with MRONJ, 10 with osteoporosis and 8 cancer patients. Bone biopsies were retrieved from the center of the necrotic bone and from visually healthy bone, and 16 S rRNA gene fragments from bacterial DNA were amplified with polymerase chain reaction...
December 7, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28154519/mining-the-proteome-of-fusobacterium-nucleatum-subsp-nucleatum-atcc-25586-for-potential-therapeutics-discovery-an-in-silico-approach
#12
Abdul Musaweer Habib, Md Saiful Islam, Md Sohel, Md Habibul Hasan Mazumder, Mohd Omar Faruk Sikder, Shah Md Shahik
The plethora of genome sequence information of bacteria in recent times has ushered in many novel strategies for antibacterial drug discovery and facilitated medical science to take up the challenge of the increasing resistance of pathogenic bacteria to current antibiotics. In this study, we adopted subtractive genomics approach to analyze the whole genome sequence of the Fusobacterium nucleatum, a human oral pathogen having association with colorectal cancer. Our study divulged 1,499 proteins of F. nucleatum, which have no homolog's in human genome...
December 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/28143770/tumor-potentiating-mechanisms-of-fusobacterium-nucleatum-a%C3%A2-multifaceted-microbe
#13
EDITORIAL
Robert A Holt, Kyla Cochrane
No abstract text is available yet for this article.
January 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28135570/the-structure-of-the-lps-o-chain-of-fusobacterium-nucleatum-strain-25586-containing-two-novel-monosaccharides-2-acetamido-2-6-dideoxy-l-altrose-and-a-5-acetimidoylamino-3-5-9-trideoxy-gluco-non-2-ulosonic-acid
#14
Evgeny Vinogradov, Frank St Michael, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. Recently, it has been gaining attention as a potential causative agent for colorectal cancer and is strongly linked with pregnancy complications including pre-term and still births. Little is known about the virulence factors of this organism, and thus we have initiated studies to examine the bacterium's surface glycochemistry. We isolated lipopolysaccharide (LPS) from F. nucleatum strain 25586 and purified and performed structural analysis on the O-antigen polysaccharide...
January 9, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28131960/three-species-biofilm-model-onto-plasma-treated-titanium-implant-surface
#15
Adaias O Matos, Antônio P Ricomini-Filho, Thamara Beline, Erika S Ogawa, Bárbara E Costa-Oliveira, Amanda B de Almeida, Francisco H Nociti Junior, Elidiane C Rangel, Nilson C da Cruz, Cortino Sukotjo, Mathew T Mathew, Valentim A R Barão
In this study, titanium (Ti) was modified with biofunctional and novel surface by micro-arc oxidation (MAO) and glow discharge plasma (GDP) and we tested the development of a three-species periodontopatogenic biofilm onto the treated commercially-pure titanium (cpTi) surfaces. Machined and sandblasted surfaces were used as control group. Several techniques for surface characterizations and monoculture on bone tissue cells were performed. A multispecies biofilm composed of Streptococcus sanguinis, Actinomyces naeslundii and Fusobacterium nucleatum was developed onto cpTi discs for 16...
January 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28126355/effect-of-opposing-implant-prostheses-on-periodontal-pathogens-in-dentures-a-pilot-study
#16
Xiaodong Zhou, Mathew T Kattadiyil, Raydolfo M Aprecio, Xiaoli Liu, Wu Zhang, Yiming Li
STATEMENT OF PROBLEM: An understanding of the presence of periodontal pathogens in denture plaque is important for the treatment of patients with edentulism. However, current data are limited and inconclusive. PURPOSE: The purpose of this pilot clinical study was to investigate whether opposing implant prostheses affect the presence of periodontal pathogens in maxillary complete dentures. MATERIAL AND METHODS: Twenty adult participants were enrolled in the study...
January 23, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28125762/association-of-dietary-patterns-with-risk-of-colorectal-cancer-subtypes-classified-by-fusobacterium-nucleatum-in-tumor-tissue
#17
Raaj S Mehta, Reiko Nishihara, Yin Cao, Mingyang Song, Kosuke Mima, Zhi Rong Qian, Jonathan A Nowak, Keisuke Kosumi, Tsuyoshi Hamada, Yohei Masugi, Susan Bullman, David A Drew, Aleksandar D Kostic, Teresa T Fung, Wendy S Garrett, Curtis Huttenhower, Kana Wu, Jeffrey A Meyerhardt, Xuehong Zhang, Walter C Willett, Edward L Giovannucci, Charles S Fuchs, Andrew T Chan, Shuji Ogino
Importance: Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of the hosts' immune response to tumor. Evidence also suggests that diet influences intestinal F nucleatum. However, the role of F nucleatum in mediating the relationship between diet and the risk of colorectal cancer is unknown. Objective: To test the hypothesis that the associations of prudent diets (rich in whole grains and dietary fiber) and Western diets (rich in red and processed meat, refined grains, and desserts) with colorectal cancer risk may differ according to the presence of F nucleatum in tumor tissue...
January 26, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28122872/prevalence-of-fusobacterium-necrophorum-in-children-presenting-with-pharyngitis
#18
Tam T Van, Laura M Cox, Mike E Cox, Jennifer Dien Bard
Fusobacterium necrophorum, an obligate anaerobic bacterium, has recently been reported to be an important cause of bacterial pharyngitis with prevalence as high as group A Streptococcus (GAS) in adolescents and young adults. Importantly, F. necrophorum is the primary causative agent of the life-threatening Lemierre's syndrome and screening of pharyngeal samples may be warranted for early detection and prevention. The aim of this study was to determine the prevalence of F. necrophorum and groups A, C/G streptococci as agents of bacterial pharyngitis in children...
January 25, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28116104/noncontiguous-finished-genome-sequence-and-description-of-fusobacterium-massiliense-sp-nov-isolated-from-human-duodenum
#19
M Mailhe, D Ricaboni, V Vitton, A Benezech, G Dubourg, C Michelle, C Andrieu, N Armstrong, F Bittar, P-E Fournier, D Raoult, M Million
The strain Marseille-P2749(T) (= CSUR P2749 = DSM 103085) was isolated as part of culturomics study from a liquid duodenum sample from a French man. Bacterial cells were Gram-negative bacilli, fusiform shaped and non-spore forming, and they grew in microaerophilic and anaerobic atmosphere. Its genome is 1 809 169 bp long and contains 1646 protein-coding genes. The DNA G+C content was 27.33 mol%. This strain exhibited a 95.9% sequence similarity with Fusobacterium periodonticum, the phylogenetically closest species with standing in nomenclature...
March 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28111632/oral-microbiome-and-history-of-smoking-and-colorectal-cancer
#20
Ikuko Kato, Adrian A Vasquez, Gregory Moyerbrailean, Susan Land, Jun Sun, Ho-Sheng Lin, Jeffrey L Ram
BACKGROUND: The equilibrium of oral microbiome may be altered by environmental factors, including cigarette smoking. Several recent studies also suggest that oral pathogens causing periodontal disease, such as Fusobacterium nucleatum, are involved in pathogenesis of colorectal cancer. METHODS: For this study oral rinse DNA samples from 190 participants in a population-based case-control study for colorectal cancer were used to amplify a V3-V4 region of bacterial 16S rRNA gene...
October 2016: Journal of Epidemiological Research
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