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https://www.readbyqxmd.com/read/29054895/lemierre-s-syndrome-variant-of-the-gut
#1
Thomas E Mellor, Natalie Mitchell, Jessica Logan
Infectious suppurative thrombophlebitis of the portal venous system, referred to as pylephlebitis, is a rare complication of intra-abdominal inflammatory processes. Advances in diagnostics and antibiotics have improved survival, but mortality remains remarkably high even in the most recent literature. The majority of patients have concomitant bacteraemia on presentation most commonly with typical gastrointestinal (GI) organisms. On rare occasion, patients have culture positive Fusobacterium, which has recently been associated with occult GI and genitourinary malignancies...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29053769/relationships-of-variations-in-the-tongue-microbiota-and-pneumonia-mortality-in-nursing-home-residents
#2
Shinya Kageyama, Toru Takeshita, Michiko Furuta, Mikiko Tomioka, Mikari Asakawa, Shino Suma, Kenji Takeuchi, Yukie Shibata, Yasuyuki Iwasa, Yoshihisa Yamashita
Background: Aspiration of oral debris, containing dense oral bacteria, is a major cause of pneumonia in elderly adults. This study investigated the relationship between tongue microbiota composition and incidence of pneumonia-related deaths, in nursing home residents. Methods: The subjects were assessed for health conditions, including their tongue microbiota, at baseline. We determined tongue microbiota profiles by 16S ribosomal RNA gene sequencing and clustering approach...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29046755/some-neck-swellings-are-serious-a-case-of-lemierre-s-syndrome
#3
Ali Raza Ghani, Mohsin Hamid, Ahsan Raza, Rizwan Naseer, Joseph Crocetti
Lemierre's syndrome also termed post-anginal septicemia, is a disease characterized by internal jugular septic thrombophlebitis leading to Fusobacterium septicemia with multiple metastatic foci following an oropharyngeal infection. Diagnosis and management is challenging and can result in fatal consequences due to potential multisystem involvement and multiple complications. We describe here a case of Lemierre's syndrome with multifocal pneumonia, acute renal failure and protracted course of illness over forty days with successful recovery...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29040443/a-dysbiosis-index-to-assess-microbial-changes-in-fecal-samples-of-dogs-with-chronic-inflammatory-enteropathy
#4
M K AlShawaqfeh, B Wajid, Y Minamoto, M Markel, J A Lidbury, J M Steiner, E Serpedin, J S Suchodolski
Recent studies have identified various bacterial groups that are altered in dogs with chronic inflammatory enteropathies (CE) compared to healthy dogs. The study aim was to use quantitative PCR (qPCR) assays to confirm these findings in a larger number of dogs, and to build a mathematical algorithm to report these microbiota changes as a dysbiosis index (DI). Fecal DNA from 95 healthy dogs and 106 dogs with histologically confirmed CE was analyzed. Samples were grouped into a training set and a validation set...
October 11, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29038128/microbial-composition-predicts-genital-tract-inflammation-and-persistent-bacterial-vaginosis-in-adolescent-south-african-women
#5
Katie Lennard, Smritee Dabee, Shaun L Barnabas, Enock Havyarimana, Anna Blakney, Shameem Z Jaumdally, Gerrit Botha, Nonhlanhla N Mkhize, Linda-Gail Bekker, David A Lewis, Glenda Gray, Nicola Mulder, Jo-Ann S Passmore, Heather B Jaspan
Young African females are at increased risk of HIV acquisition, and genital inflammation or the vaginal microbiome may contribute to this risk. We studied these factors in 168 HIV negative South African adolescent women aged 16-22 years. Unsupervised clustering of 16S rRNA gene sequences revealed three clusters (subtypes), one of which was strongly associated with genital inflammation. In a multivariate model, microbiome compositional subtype and hormonal contraception were significantly associated with genital inflammation...
October 16, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29035085/lung-microbiota-is-related-to-smoking-status-and-to-development-of-ards-in-critically-ill-trauma-patients
#6
Ariane R Panzer, Susan V Lynch, Chaz Langelier, Jason D Christie, Kathryn McCauley, Mary Nelson, Christopher K Cheung, Neal L Benowitz, Mitchell J Cohen, Carolyn S Calfee
RATIONALE: Cigarette smoking is associated with increased risk of acute respiratory distress syndrome (ARDS) in patients following severe trauma; however, mechanisms underlying this association are unknown. OBJECTIVES: To determine whether cigarette smoking contributes to ARDS development following trauma by altering community composition of the lung microbiota Methods: We studied lung microbiota of mechanically ventilated patients admitted to the intensive care unit (ICU) following severe blunt trauma using 16S rRNA gene amplicon sequencing of endotracheal aspirate (ETA) samples obtained upon ICU admission (n=74) and at 48 hours post-admission (n=30)...
October 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29033369/fecal-clostridium-symbiosum-for-noninvasive-detection-of-early-and-advanced-colorectal-cancer-test-and-validation-studies
#7
Yuan-Hong Xie, Qin-Yan Gao, Guo-Xiang Cai, Xiao-Ming Sun, Tian-Hui Zou, Hui-Min Chen, Si-Yi Yu, Yi-Wen Qiu, Wei-Qi Gu, Xiao-Yu Chen, Yun Cui, Danfeng Sun, Zhan-Ju Liu, San-Jun Cai, Jie Xu, Ying-Xuan Chen, Jing-Yuan Fang
OBJECTIVE: Current non-invasive early detection of colorectal cancer (CRC) requires improvement. We aimed to identified a fecal Clostridium symbiosum-based biomarker for early and advanced colorectal cancer detection. DESIGN: In the test stage, the relative abundance of Clostridium symbiosum (C. symbiosum) was measured by qPCR in 781 cases including 242 controls, 212 colorectal adenoma (CRA) patients, 109 early CRC (tumor restricted to the submucosa) patients, 218 advanced CRC patients...
October 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29031240/colonization-of-oropharynx-and-lower-respiratory-tract-in-critical-patients-risk-of-ventilator-associated-pneumonia
#8
Ivany Machado de Carvalho Baptista, Frederico Canato Martinho, Gustavo Giacomelli Nascimento, Carlos Eduardo da Rocha Santos, Renata Falchete do Prado, Marcia Carneiro Valera
OBJECTIVE: To investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (BAL), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard DNA-DNA hybridisation. Also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship between VAP (ventilator-associated pneumonia) and bacterial species studied...
October 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29026618/a-case-of-polymicrobial-anaerobic-spondylodiscitis-due-to-parvimonas-micra-and-fusobacterium-nucleatum
#9
Leanne M Cleaver, Shara Palanivel, Damien Mack, Simon Warren
Introduction. Here, we present a case of polymicrobial anaerobic spondylodiscitis. Case Presentation. A forty-five year-old female patient was referred to a specialist orthopaedic hospital with an eight week history of back pain without fevers. X-ray imaging and magnetic resonance imaging showed acute osteomyelitis of the twelfth thoracic and first lumbar vertebrae. Prolonged enrichment cultures grew Parvimonas micra and Fusobacterium nucleatum, identified by matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS)...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29024797/nlrx1-modulates-differentially-nlrp3-inflammasome-activation-and-nf-%C3%AE%C2%BAb-signaling-during-fusobacterium-nucleatum-infection
#10
Shu-Chen Hung, Pei-Rong Huang, Cássio Luiz Coutinho Almeida-da-Silva, Kalina R Atanasova, Ozlem Yilmaz, David M Ojcius
NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, enhances mitochondrial ROS (mROS) generation. mROS can activate the NLRP3 inflammasome, yet the role of NLRX1 in NLRP3 inflammasome activation has not been examined. In this study, we revealed the mechanism by which NLRX1 positively regulates ATP-induced NLRP3 inflammasome activation through mROS in gingival epithelial cells (GECs)...
October 9, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29021252/a-chemical-and-biological-toolbox-for-type-vd-secretion-characterization-of-the-phospholipase-a1-autotransporter-fpla-from-fusobacterium-nucleatum
#11
Michael A Casasanta, Christopher C Yoo, Hans B Smith, Alison J Duncan, Kyla Cochrane, Ann C Varano, Emma Allen-Vercoe, Daniel J Slade
Fusobacterium nucleatum is an oral pathogen that is linked to multiple human infections and colorectal cancer. Strikingly, F. nucleatum achieves virulence in the absence of large, multi-protein secretion systems (Type I, II, III, IV, and VI) which are widely used by Gram-negative bacteria for pathogenesis. By contrast, F. nucleatum strains contain genomic expansions of Type V secreted effectors (autotransporters) that are critical for host cell adherence, invasion, and biofilm formation. Here we present the first characterization of a F...
October 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29016688/tlr2-tlr4-activation-induces-tregs-and-suppresses-intestinal-inflammation-caused-by-fusobacterium-nucleatum-in-vivo
#12
Yin-Ping Jia, Kun Wang, Zhu-Jun Zhang, Ya-Nan Tong, Dan Han, Chun-Yu Hu, Qian Li, Yang Xiang, Xu-Hu Mao, Bin Tang
Toll-like receptors (TLRs) 2 and 4 play critical roles in intestinal inflammation caused by Fusobacterium nucleatum (F. nucleatum) infection, but the role of TLR2/TLR4 in regulation of proinflammatory cytokines remains unknown. In this study, through microarray analysis and qRT-PCR, we showed that TLR2/TLR4 are involved in the F. nucleatum-induced inflammatory signaling pathway in Caco-2 cells, C57BL/6 mice and human clinical specimens. In TLR2-/- and TLR4-/- mice, F. nucleatum infection resulted in increased colonization of the bacteria and production of the proinflammatory cytokines IL-8, IL-1β and TNF-α...
2017: PloS One
https://www.readbyqxmd.com/read/28993327/in-vitro-activity-of-pexiganan-and-10-comparator-antimicrobials-against-502-anaerobic-isolates-recovered-from-skin-and-skin-structure-infections-sssi
#13
Ellie J C Goldstein, Diane M Citron, Kerin L Tyrrell, Eliza S Leoncio
Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. MIC90s were as follows: B. fragilis, 16 μg/ml; other Bacteroidesfragilis group spp., 4 μg/ml; Prevotella and Fusobacterium spp., 32 μg/ml; and Porphyromonas spp., 64 μg/ml; P. acnes, 4 μg/ml; E. lenta and P. anaerobius, 32 μg/ml; other Gram-positive rods and cocci, 4 μg/ml; Clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. Pexiganan cream shows potential as adjunctive therapy for SSSIs involving anaerobes...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28988196/the-oral-microbiota-in-colorectal-cancer-is-distinctive-and-predictive
#14
Burkhardt Flemer, Ryan D Warren, Maurice P Barrett, Katryna Cisek, Anubhav Das, Ian B Jeffery, Eimear Hurley, Micheal O'Riordain, Fergus Shanahan, Paul W O'Toole
BACKGROUND AND AIMS: Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC. METHODS: We profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103)...
October 7, 2017: Gut
https://www.readbyqxmd.com/read/28987726/inhibition-of-malodorous-gas-formation-by-oral-bacteria-with-cetylpyridinium-and-zinc-chloride
#15
Jeong Hyun Kang, Dae Jeong Kim, Bong Kyu Choi, Ji Woon Park
OBJECTIVE: The antimicrobial efficacy of zinc- (ZnCl2) and cetylpyridinium-chloride (CPC) and their inhibition capacity on volatile sulfur compound (VSC) production by oral bacterial strains were investigated. DESIGN: Minimum inhibitory concentrations (MIC) and growth curves were determined for ZnCl2, CPC, and CPC with ZnCl2 solutions against eight oral microorganisms (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, Tannerella forsythia, Staphylococcus aureus and Streptococcus mutans) known to be involved in the pathophysiology of both halitosis and periodontal disease...
September 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28986386/bacterial-isolates-and-antimicrobial-susceptibilities-from-odontogenic-abscesses-in-rabbits-48-cases
#16
Sara Gardhouse, David Sanchez-Migallon Guzman, Joanne Paul-Murphy, Barbara A Byrne, Michelle G Hawkins
The medical record database of a veterinary teaching hospital was searched from 2000 through 2014 for records of client-owned rabbits with positive cultures from odontogenic abscesses. Data reviewed included sex, age, abscess location, sampling technique, previous antimicrobial treatments, microorganisms identified and antibiotic susceptibility of aerobic bacteria. Forty-eight client owned rabbits with one or more odontogenic abscesses and culture results were evaluated. One hundred and eighty-five isolates (52 aerobic, 133 anaerobic) were identified from 61 positive cultures from odontogenic abscesses...
October 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28977914/potential-link-between-fusobacterium-enrichment-and-dna-methylation-accumulation-in-the-inflammatory-colonic-mucosa-in-ulcerative-colitis
#17
Tomomitsu Tahara, Ichiro Hirata, Naoko Nakano, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Hyuga Yamada, Dai Yoshida, Takafumi Ohmori, Kohei Maeda, Naruomi Komura, Hirokazu Ikuno, Yasutaka Jodai, Toshiaki Kamano, Mitsuo Nagasaka, Yoshihito Nakagawa, Tetsuya Tuskamoto, Makoto Urano, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
BACKGROUND AND AIM: Fusobacterium enrichment has been associated with colorectal cancer development. Ulcerative colitis (UC) associated tumorigenesis is characterized as high degree of methylation accumulation through continuous colonic inflammation. The aim of this study was to investigate a potential link between Fusobacterium enrichment and DNA methylation accumulation in the inflammatory colonic mucosa in UC. METHODS: In the candidate analysis, inflamed colonic mucosa from 86 UC patients were characterized the methylation status of colorectal a panel of cancer related 24 genes...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28971271/association-between-high-risk-for-preterm-birth-and-changes-in-gingiva-parameters-during-pregnancy-a-prospective-cohort-study
#18
Anne Brigitte Kruse, Anja C Kuerschner, Mirjam Kunze, Johan P Woelber, Ali Al-Ahmad, Annette Wittmer, Kirstin Vach, Petra Ratka-Krueger
OBJECTIVES: The objective of this study was to investigate clinical and microbiological gingival changes during pregnancy in women without periodontal disease. Additionally, these parameters were to be compared in women with high risk for preterm birth and women with a normal course of pregnancy. METHOD AND MATERIALS: Group I consisted of 40 subjects at high risk for preterm birth, while group II involved 49 subjects with a normal course of pregnancy. The control group (III) was made up of 50 non-pregnant women...
October 2, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28968715/fusobacterium-and-colorectal-carcinogenesis
#19
Deniz Can Güven, Omer Dizdar
No abstract text is available yet for this article.
August 26, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28968650/response-to-comments-on-fusobacterium-and-colorectal-cancer-causal-factor-or-passenger-results-from-a-large-colorectal-cancer-screening-study
#20
Efrat L Amitay, Hermann Brenner
No abstract text is available yet for this article.
September 8, 2017: Carcinogenesis
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