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Fusobacterium

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https://www.readbyqxmd.com/read/28823057/fusobacterium-nucleatum-as-a-prognostic-marker-of-colorectal-cancer-in-a-japanese-population
#1
Yuko Yamaoka, Yutaka Suehiro, Shinichi Hashimoto, Tomomi Hoshida, Michiyo Fujimoto, Michiya Watanabe, Daiki Imanaga, Kouhei Sakai, Toshihiko Matsumoto, Mitsuaki Nishioka, Taro Takami, Nobuaki Suzuki, Shoichi Hazama, Hiroaki Nagano, Isao Sakaida, Takahiro Yamasaki
BACKGROUND: Accumulating evidence shows an overabundance of Fusobacterium nucleatum in colorectal tumor tissues. However, the correlation between the absolute copy number of F. nucleatum in colorectal cancer tissues and colorectal cancer progression is unclear from previous reports. Therefore, we performed a study to compare the abundance of F. nucleatum in colorectal tissues with clinicopathologic and molecular features of colorectal cancer. METHODS: We collected 100 colorectal cancer tissues and 72 matched normal-appearing mucosal tissues...
August 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28798773/planktonic-growth-of-pseudomonas-aeruginosa-around-a-dual-species-biofilm-supports-the-growth-of-fusobacterium-nucleatum-within-that-biofilm
#2
James C Wang, Joehassin Cordero, Yan Sun, Mayank Aranke, Randall Wolcott, Jane A Colmer-Hamood, Abdul N Hamood
PURPOSE: The goal of this study was to understand the potential interaction between Pseudomonas aeruginosa and Fusobacterium nucleatum within the middle ear. METHODS: We examined the microbiota of ear fluid and tympanostomy tubes (TTs) obtained from patients with posttympanostomy tube otorrhea. We also examined biofilms formed by P. aeruginosa and F. nucleatum, singly or together, under aerobic or anaerobic conditions. RESULTS: While the facultative anaerobe P...
2017: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/28797303/combined-antioxidant-effects-of-neem-extract-bacteria-red-blood-cells-and-lysozyme-possible-relation-to-periodontal-disease
#3
Leali Heyman, Yael Houri-Haddad, Samuel N Heyman, Isaac Ginsburg, Yossi Gleitman, Osnat Feuerstein
BACKGROUND: The common usage of chewing sticks prepared from Neem tree (Azadirachta indica) in India suggests its potential efficacy in periodontal diseases. The objective of this study is to explore the antibacterial effects of Neem leaf extract on the periodontophatic bacteria Porphyromonas gingivalis and Fusobacterium nucleatum, and its antioxidant capacities alone and in combination with bacteria and polycationic peptides that may be at the site of inflammation. METHODS: Neem leaf extract was prepared by ethanol extraction...
August 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28796833/bile-microbiota-in-primary-sclerosing-cholangitis-impact-on-disease-progression-and-development-of-biliary-dysplasia
#4
Pedro Pereira, Velma Aho, Johanna Arola, Sonja Boyd, Kalle Jokelainen, Lars Paulin, Petri Auvinen, Martti Färkkilä
OBJECTIVE: The etiopathogenesis and risk for development of biliary neoplasia in primary sclerosing cholangitis (PSC) are largely unknown. Microbes or their metabolites have been suggested to play a role. To explore this potential microbial involvement, we evaluated the differences in biliary microbiota in PSC patients at an early disease stage without previous endoscopic retrograde cholangiography (ERC) examinations, advanced disease stage, and with biliary dysplasia or cholangiocarcinoma...
2017: PloS One
https://www.readbyqxmd.com/read/28793925/perturbed-human-sub-networks-by-fusobacterium-nucleatum-candidate-virulence-proteins
#5
Andreas Zanzoni, Lionel Spinelli, Shérazade Braham, Christine Brun
BACKGROUND: Fusobacterium nucleatum is a gram-negative anaerobic species residing in the oral cavity and implicated in several inflammatory processes in the human body. Although F. nucleatum abundance is increased in inflammatory bowel disease subjects and is prevalent in colorectal cancer patients, the causal role of the bacterium in gastrointestinal disorders and the mechanistic details of host cell functions subversion are not fully understood. RESULTS: We devised a computational strategy to identify putative secreted F...
August 10, 2017: Microbiome
https://www.readbyqxmd.com/read/28793309/the-microbiome-in-urogenital-schistosomiasis-and-induced-bladder-pathologies
#6
Adewale S Adebayo, Mangesh Survayanshi, Shrikanth Bhute, Atinuke M Agunloye, Raphael D Isokpehi, Chiaka I Anumudu, Yogesh S Shouche
BACKGROUND: Human schistosomiasis is a highly prevalent neglected tropical disease (NTD) caused by Schistosoma species. Research on the molecular mechanisms influencing the outcomes of bladder infection by Schistosoma haematobium is urgently needed to develop new diagnostics, therapeutics and infection prevention strategies. The objective of the research study was to determine the microbiome features and changes in urine during urogenital schistosomiasis and induced bladder pathologies...
August 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28776753/assessment-of-the-involvement-of-the-macrophage-migration-inhibitory-factor-glucocorticoid-regulatory-dyad-in-the-expression-of-matrix-metalloproteinase-2-during-periodontitis
#7
Josefine Hirschfeld, Mohammed Howait, Alexandru Movila, Marijo Parčina, Isabelle Bekeredjian-Ding, James Deschner, Søren Jepsen, Toshihisa Kawai
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and counter-regulator of endogenous glucocorticoids (GCs). It is implicated in acute and chronic inflammatory diseases. This study investigated the role of the MIF-GC regulatory dyad in the expression and release of matrix metalloproteinase-2 (MMP-2) during periodontitis, in vivo and in vitro. In a Mif-knockout (KO) mouse model of ligature-induced periodontitis, gingival tissues and blood were collected and analysed for levels of interleukin-6 (IL-6), MIF, MMP-2, and corticosterone...
August 4, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28771533/mechanisms-by-which-porphyromonas-gingivalis-evades-innate-immunity
#8
Kaveh Abdi, Tsute Chen, Brian A Klein, Albert K Tai, Jill Coursen, Xiangdong Liu, Jeff Skinner, Saravanan Periasamy, Youngnim Choi, Benedikt M Kessler, Robert J Palmer, Apostolos Gittis, Polly Matzinger, Margaret J Duncan, Nevil J Singh
The oral cavity is home to unique resident microbial communities whose interactions with host immunity are less frequently studied than those of the intestinal microbiome. We examined the stimulatory capacity and the interactions of two oral bacteria, Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum), on Dendritic Cell (DC) activation, comparing them to the effects of the well-studied intestinal microbe Escherichia coli (E. coli). Unlike F. nucleatum and E. coli, P. gingivalis failed to activate DCs, and in fact silenced DC responses induced by F...
2017: PloS One
https://www.readbyqxmd.com/read/28767339/assessing-gut-microbiota-perturbations-during-the-early-phase-of-infectious-diarrhea-in-vietnamese-children
#9
Hao Chung The, Paola Florez de Sessions, Song Jie, Duy Pham Thanh, Corinne N Thompson, Chau Nguyen Ngoc Minh, Collins Wenhan Chu, Tuan-Anh Tran, Nicholas R Thomson, Guy E Thwaites, Maia A Rabaa, Martin Hibberd, Stephen Baker
Diarrheal diseases remain the second most common cause of mortality in young children in developing countries. Efforts have been made to explore the impact of diarrhea on bacterial communities in the human gut, but a thorough understanding has been impeded by inadequate resolution in bacterial identification and the examination of only few etiological agents. Here, by profiling an extended region of the 16S rRNA gene in the fecal microbiome, we aimed to elucidate the nature of gut microbiome perturbations during the early phase of infectious diarrhea caused by various etiological agents in Vietnamese children...
August 2, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28766990/involvement-of-nlrp10-in-il-1%C3%AE-induction-of-oral-epithelial-cells-by-periodontal-pathogens
#10
Seok-Joo Lee, Bong-Kyu Choi
This study investigated the pathogenesis of periodontitis and the role of nucleotide-binding oligomerization domain-like receptor protein 10 (NLRP10). The human oral epithelial cell line HOK-16B was infected with two periodontal pathogens, Tannerella forsythia and Fusobacterium nucleatum, at various MOIs. RT-PCR and immunoblotting demonstrated that infection increased mRNA and protein expression of NLRP10, respectively. The siRNA-mediated NLRP10 knockdown significantly reduced IL-1α expression and secretion...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28766745/exploring-the-microbiome-of-healthy-and-diseased-peri-implant-sites-using-illumina-sequencing
#11
I Sanz-Martin, J Doolittle-Hall, R P Teles, M Patel, G N Belibasakis, C H Hämmerle, R E Jung, F R F Teles
AIM: To compare the microbiome of healthy (H) and diseased (P) peri-implant sites and determine the core peri-implant microbiome. MATERIALS AND METHODS: Submucosal biofilms from 32 H and 35 P sites were analyzed using 16S rRNA sequencing (MiSeq, Illumina), QIIME and HOMINGS. Differences between groups were determined using Principal Coordinate Analysis (PCoA), t-tests and Wilcoxon rank sum test and FDR-adjusted. The peri-implant core microbiome was determined. RESULTS: PCoA showed partitioning between H and P at all taxonomic levels...
August 2, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28761687/systemic-sclerosis-is-associated-with-specific-alterations-in-gastrointestinal-microbiota-in-two-independent-cohorts
#12
Elizabeth R Volkmann, Anna-Maria Hoffmann-Vold, Yu-Ling Chang, Jonathan P Jacobs, Kirsten Tillisch, Emeran A Mayer, Philip J Clements, Johannes R Hov, Martin Kummen, Øyvind Midtvedt, Venu Lagishetty, Lin Chang, Jennifer S Labus, Øyvind Molberg, Jonathan Braun
OBJECTIVE: To compare faecal microbial composition in patients with systemic sclerosis (SSc) from 2 independent cohorts with controls and to determine whether certain genera are associated with SSc-gastrointestinal tract (GIT) symptoms. DESIGN: Adult patients with SSc from the University of California, Los Angeles (UCLA) and Oslo University Hospital (OUH) and healthy controls participated in this study (1:1:1). All participants provided stool specimens for 16S rRNA sequencing...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28760931/streptococcus-pneumoniae-colonization-is-required-to-alter-the-nasal-microbiota-in-cigarette-smoke-exposed-mice
#13
Pamela Shen, Fiona J Whelan, L Patrick Schenck, Joshua J C McGrath, Gilles Vanderstocken, Dawn M E Bowdish, Michael G Surette, Martin R Stämpfli
Smokers have nasal microbiota dysbiosis, with an increased frequency of colonizing bacterial pathogens. It is possible that cigarette smoke increases pathogen acquisition by perturbing the microbiota and decreasing colonization resistance. However, it is difficult to disentangle microbiota dysbiosis due to cigarette smoke exposure from microbiota changes caused by increased pathogen acquisition in human smokers. Utilizing an experimental mouse model, we investigated the impact of cigarette smoke on the nasal microbiota in the absence and presence of nasal pneumococcal colonization...
July 31, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28757933/prevalence-of-periodontal-pathogens-among-italian-patients-with-chronic-periodontitis-a-retrospective-study-on-2992-patients
#14
L Tettamanti, R M Gaudio, F Cura, D Mucchi, N Illuzzi, A Tagliabue
PURPOSE: The aim of the present study was to evaluate the prevalence of some periodontal pathogens in Italian adults with chronic periodontitis. MATERIALS AND METHODS: The sample consisted of 2992 patients with a clinical diagnosis of chronic periodontitis, based on the criteria of the American Academy of Periodontology, sampled in the period 2013-2016: 2108 patients were from Northern, 690 from Central and 194 from Southern Italy. Porphyromonas gengivalis, Treponema denticola, and Tannerella forsythia were investigated in all patients of the present study, while Campylobacter rectus, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans only in 2514 (84%) patients...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28756939/bacteriology-of-peritonsillar-abscess-the-changing-trend-and-predisposing-factors
#15
Yi-Wen Tsai, Yu-Hsi Liu, Hsing-Hao Su
INTRODUCTION: Peritonsillar abscess (PTA) is the most common deep neck infection. The infectious microorganism may be different according to clinical factors. OBJECTIVE: To identify the major causative pathogen of peritonsillar abscess and investigate the relationship between the causative pathogen, host clinical factors, and hospitalization duration. METHODS: This retrospective study included 415 hospitalized patients diagnosed with peritonsillar abscess who were admitted to a tertiary medical center from June 1990 to June 2013...
July 17, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28755761/do-quaternary-ammonium-monomers-induce-drug-resistance-in-cariogenic-endodontic-and-periodontal-bacterial-species
#16
Suping Wang, Haohao Wang, Biao Ren, Hao Li, Michael D Weir, Xuedong Zhou, Thomas W Oates, Lei Cheng, Hockin H K Xu
OBJECTIVES: Antibacterial monomers were developed to combat oral biofilm acids and caries; however, little is known on whether quaternary ammonium monomers (QAMs) would induce drug resistance in oral bacteria. The objective of this study was to investigate the effects of new antimicrobial monomers dimethylaminohexadecyl methacrylate (DMAHDM) and dimethylaminododecyl methacrylate (DMADDM) on the induction of drug resistance in eight species of cariogenic, endodontic and periodontal bacteria for the first time...
July 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28754755/bacteraemia-and-liver-abscess-due-to-fusobacterium-necrophorum
#17
Rafael García Carretero, Marta Lopez-Lomba, Oscar Vazquez-Gomez, Belen Rodriguez-Maya
Fusobacterium necrophorum is the oropharyngeal pathogen usually associated with Lemierre's syndrome, a pharyngeal infection which evolves to sepsis, septic emboli and thrombophlebitis of the adjacent neck vessels. It is an uncommon causative bacteria of a liver abscess, and an extensive workup should, therefore, be performed in order to rule out potential sources of the infection. This case report describes the workup that led to the diagnosis of a colorectal carcinoma, which was deemed to be the source of the Fusobacterium bacteraemia...
July 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28753429/fusobacterium-nucleatum-promotes-chemoresistance-to-colorectal-cancer-by-modulating-autophagy
#18
TaChung Yu, Fangfang Guo, Yanan Yu, Tiantian Sun, Dan Ma, Jixuan Han, Yun Qian, Ilona Kryczek, Danfeng Sun, Nisha Nagarsheth, Yingxuan Chen, Haoyan Chen, Jie Hong, Weiping Zou, Jing-Yuan Fang
Gut microbiota are linked to chronic inflammation and carcinogenesis. Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer patients. Here, we investigated the contribution of gut microbiota to chemoresistance in patients with colorectal cancer. We found that Fusobacterium (F.) nucleatum was abundant in colorectal cancer tissues in patients with recurrence post chemotherapy, and was associated with patient clinicopathological characterisitcs. Furthermore, our bioinformatic and functional studies demonstrated that F...
July 27, 2017: Cell
https://www.readbyqxmd.com/read/28753421/drugs-bugs-and-cancer-fusobacterium-nucleatum-promotes-chemoresistance-in-colorectal-cancer
#19
Azucena Ramos, Michael T Hemann
The tumor microenvironment has recently been shown to play decisive roles in chemotherapeutic response. In this issue of Cell, Yu et al. add to these findings by identifying the bacterium Fusobacterium nucleatum as a previously unrecognized chemoresistance mediator in colorectal cancer, thereby establishing the microbiota as a potential therapeutic target.
July 27, 2017: Cell
https://www.readbyqxmd.com/read/28752291/composition-and-abundance-of-microbiota-in-the-pharynx-in-patients-with-laryngeal-carcinoma-and-vocal-cord-polyps
#20
Hongli Gong, Boyan Wang, Yi Shi, Yong Shi, Xiyan Xiao, Pengyu Cao, Lei Tao, Yuezhu Wang, Liang Zhou
The pharynx is an important site of microbiota colonization, but the bacterial populations at this site have been relatively unexplored by culture-independent approaches. The aim of this study was to characterize the microbiota structure of the pharynx. Pyrosequencing of 16S rRNA gene libraries was used to characterize the pharyngeal microbiota using swab samples from 68 subjects with laryngeal cancer and 28 subjects with vocal cord polyps. Overall, the major phylum was Firmicutes, with Streptococcus as the predominant genus in the pharyngeal communities...
August 2017: Journal of Microbiology / the Microbiological Society of Korea
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