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Claudio Foschi, Valeria Gaspari, Paola Sgubbi, Melissa Salvo, Antonietta D'Antuono, Antonella Marangoni
PURPOSE: We assessed the prevalence and predictors of Chlamydia trachomatis, Neisseriagonorrhoeae and Mycoplasmagenitalium rectal infections in a population of 'men having sex with men' (MSM). METHODOLOGY: From January to November 2017, 165 MSM attending a STI outpatients clinic in Bologna (Italy) and reporting unsafe anal intercourses were enrolled. An ano-rectal swab was collected from each patient: chlamydial and gonococcal infections were diagnosed by a commercial NAAT, whereas an in-house quantitative PCR was used for M...
June 21, 2018: Journal of Medical Microbiology
Laura E Norton, Brian R Lee, Lory Harte, Keith Mann, Jason G Newland, R Alan Grimes, Angela L Myers
BACKGROUND AND OBJECTIVES: Acute pharyngitis is a common diagnosis in ambulatory pediatrics. The Infectious Diseases Society of America (IDSA) clinical practice guideline for group A streptococcal (GAS) pharyngitis recommends strict criteria for GAS testing to avoid misdiagnosis and unnecessary treatment of children who are colonized with group A Streptococcus . We sought to improve adherence to the IDSA guideline for testing and treatment of GAS pharyngitis in a large community pediatrics practice...
June 20, 2018: Pediatrics
Gersende Maugars, Marie-Chanteuse Manirafasha, Evelyse Grousset, Viviane Boulo, Jehan-Hervé Lignot
Gene expression of key ion transporters (the Na+ /K+ -ATPase NKA, the Na+ , K+ -2Cl- cotransporter NKCC1, and CFTR) in the gills, opercular inner epithelium, and pseudobranch of European seabass juveniles (Dicentrarchus labrax) were studied after acute transfer up to 4 days from seawater (SW) to freshwater (FW). The functional remodeling of these organs was also studied. Handling stress (SW to SW transfer) rapidly induced a transcript level decrease for the three ion transporters in the gills and operculum...
June 19, 2018: Fish Physiology and Biochemistry
Shahla Momeni Danaei, Shabnam Ajami, Hamideh Etemadi, Niloofar Azadeh
Background: Literature is controversial in regard with alterations in pharyngeal airway dimensions subsequent to maxillary protraction. The correlation between maxillary protraction and sagittal airway dimension was investigated in association with tongue and soft palate position in skeletal Class III children. The results were compared with those of an untreated Class III and a Class I malocclusion control group. Materials and Methods: In this cross-sectional study pre- and post-treatment cephalometric radiographs of 19 Class III patients (6 males, 13 females; mean age, 7...
May 2018: Dental Research Journal
Inés Bado, Romina Papa-Ezdra, Jose F Delgado-Blas, Micaela Gaudio, Claudia Gutiérrez, Nicolás F Cordeiro, Virginia García-Fulgueiras, Lucía Araújo Pirez, Verónica Seija, Julio C Medina, Gloria Rieppi, Bruno Gonzalez-Zorn, Rafael Vignoli
Carbapenem-resistant Acinetobacter baumannii (CRAB) infections are an increasing concern in intensive care units (ICUs) worldwide. The combination of carbapenemases and 16S rRNA-methyltransferases (16S-RMTases) further reduces the therapeutic options. OXA-carbapenemase/A. baumannii clone tandems in Latin America have already been described; however, no information exists in this region regarding the occurrence of 16S-RMTases in this microorganism. In addition, the epidemiology of A. baumannii in ICUs and its associated resistance profiles are poorly understood...
June 19, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Florence A Aeschlimann, Ronald M Laxer
PURPOSE OF REVIEW: This review aims at summarizing the current knowledge of A20 haploinsufficiency and other paediatric inflammatory disorders with mucosal involvement. RECENT FINDINGS: A20 haploinsufficiency is a newly described autoinflammatory disease caused by loss-of-function mutations in TNFAIP3 that result in the activation of the nuclear factor (NF)-kB pathway. Patients may present with dominantly inherited, early-onset systemic inflammation and a Behçet-like disease, or a variety of autoinflammatory and autoimmune features...
June 16, 2018: Current Opinion in Rheumatology
Fahimeh Haghighatdoost, Awat Feizi, Ahmad Esmaeilzadeh, Ammar Hassanzadeh Keshteli, Hamidreza Roohafza, Hamid Afshar, Peyman Adibi
OBJECTIVE: Although dietary patterns have been evaluated in relation to psychological disorders, their associations with psychosomatic complaints are unclear. We investigated relations of dietary patterns with psychosomatic complaints profiles. METHODS: In this cross-sectional study, a total of 3363 adults were included. Dietary intakes and psychosomatic complaints were assessed using self-administered Persian validated questionnaires. Dietary patterns and psychosomatic symptom profiles were identified using exploratory factor analysis...
June 18, 2018: Nutritional Neuroscience
Melania Marques, Pedro R Genta, Ali Azarbarzin, Scott A Sands, Luigi Taranto-Montemurro, Ludovico Messineo, David P White, Andrew Wellman
OBJECTIVES: We hypothesized that preferential retropalatal as compared to retroglossal collapse in patients with obstructive sleep apnea was due to a narrower retropalatal area and a higher retropalatal compliance. Patients with a greater retropalatal compliance would exhibit a recognizable increase in negative effort dependence (NED). METHODS: Fourteen patients underwent upper airway endoscopy with simultaneous recordings of airflow and pharyngeal pressure during natural sleep...
June 15, 2018: Respiratory Physiology & Neurobiology
Chris R Kenyon, Ilan S Schwartz
Contemporary strategies to curtail the emergence of antimicrobial resistance in Neisseria gonorrhoeae include screening for and treating asymptomatic infections in high-prevalence populations in whom antimicrobial drug-resistant infections have typically emerged. We argue that antimicrobial resistance in these groups is driven by a combination of dense sexual network connectivity and antimicrobial drug exposure (for example, through screen-and-treat strategies for asymptomatic N. gonorrhoeae infection). Sexual network connectivity sustains a high-equilibrium prevalence of N...
July 2018: Emerging Infectious Diseases
K Bhagya Lakshmi, Sri Harsha Yelchuru, V Chandrika, O G Lakshmikar, V Lakshmi Sagar, G Vivek Reddy
Aim: The main aim is to determine whether growth pattern had an effect on the upper airway by comparing different craniofacial patterns with pharyngeal widths and its importance during the clinical examination. Methodology: Sixty lateral cephalograms of patients aged between 16 and 24 years with no pharyngeal pathology or nasal obstruction were selected for the study. These were divided into skeletal Class I ( n = 30) and skeletal Class II ( n = 30) using ANB angle subdivided into normodivergent, hyperdivergent, and hypodivergent facial patterns based on SN-GoGn angle...
May 2018: Journal of International Society of Preventive & Community Dentistry
Gilad Horowitz, Ali Hosni, Eugene Yu, Wei Xu, Lin Lu, Michael Au, Peter R Dixon, Dale Brown, Douglas B Chepeha, Ralph W Gilbert, David P Goldstein, Patrick J Gullane, Jonathan C Irish, Andrew Bayley, John Cho, Meredith Giuliani, Shao Hui Huang, Andrew Hope, John Kim, Brian O'Sullivan, Jolie Ringash, John Waldron, Ilan Weinreb, Bayardo Perez-Ordonez, Scott V Bratman, John R de Almeida
OBJECTIVE: (1) To estimate the prevalence of radiographically positive Retro-Pharyngeal Lymph Nodes (RPLN) in unknown primary carcinoma of the head and neck and (2) to determine the prognostic implications of radiographically positive RPLN and other radiographic features (3) to identify patients at low risk for retropharyngeal metastasis. MATERIALS AND METHODS: The medical records of all 68 eligible patients treated at the Princess Margaret Cancer Centre between 2000 and 2014 were retrospectively reviewed for demographic, clinical, pathologic, and radiologic data...
July 2018: Oral Oncology
Juan Guillermo Sánchez-Acuña, Laura Elena Franco-Garrocho, Omar Esteban Durán-Macías, Aarón Peralta-Mata
Lipoma is a benign entity with a poor incidence in craniofacial region. The most frequent tumors in the maxillo pharyngeal space are those that occur in the major and minor salivary glands, with a higher incidence of pleomorphic adenoma, also consider a benign entity. The transmandibular approach offers a great advantage in terms of visibility during the surgery. Achieving a lower morbidity, due to the fact that anatomic structures of anterior (prestyloid) and posterior (retrostyloid) compartments are involved...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
Kazlin N Mason, Kelly Hauhuth, Jamie L Perry, John E Riski
Prior to performing secondary surgeries, lateral cephalograms have been used during phonation to evaluate the point of attempted velopharyngeal contact along the posterior pharyngeal wall relative to the palatal plane and the first cervical vertebra. The ability to quantify the height of velopharyngeal closure is an important aspect of planning corrective surgeries for velopharyngeal dysfunction. However, issues with patient compliance during the imaging process can present difficulties for obtaining adequate preoperative imaging data...
June 13, 2018: Journal of Craniofacial Surgery
Jinshuo Fan, Zhilei Lv, Guanghai Yang, Ting Ting Liao, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Shuqing Liu, Yang Jin
Retinoic acid receptor-related orphan receptors (RORs) include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). These receptors are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis. Researches on RORs contributing to cancer-related processes have been growing, and they provide evidence that RORs are likely to be considered as potential therapeutic targets in many cancers...
2018: Frontiers in Immunology
Cornelis J Boogerd, Xiaoming Zhu, Ivy Aneas, Noboru J Sakabe, Lunfeng Zhang, Debora R Sobreira, Lindsey E Montefiori, Julius Bogomolovas, Amelia C Joslin, Bin Zhou, Ju Chen, Marcelo Nobrega, Sylvia M Evans
<u>Rationale:</u> Mutations in the transcription factor TBX20 are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by E9.5. As Tbx20 is expressed in multiple cell lineages required for myocardial development, including pharyngeal endoderm, cardiogenic mesoderm, endocardium, and myocardium, the cell type specific requirement for Tbx20 in early myocardial development remains to be explored. <u>Objective:</u> Here, we investigated roles of Tbx20 in mid-gestation cardiomyocytes for heart development...
June 14, 2018: Circulation Research
Guillaume Manneveau, Jeanne Lecallard, Chantal Thorin, Hugo Pamela, Caroline Tessier
OBJECTIVE: To compare the topographic modifications and tactile sensitivity of the pharynx and larynx after administration of four sedative and analgesic protocols in standing horses. STUDY DESIGN: Experimental, observer-blinded, crossover study. ANIMALS: Eight healthy mares. METHODS: Five protocols were evaluated: 1) xylazine and butorphanol administered intravenously (IV); 2) detomidine and butorphanol administered IV; 3) xylazine administered IV and lidocaine topically; 4) detomidine administered IV and lidocaine topically and 5) no analgesia or sedation (control)...
May 1, 2018: Veterinary Anaesthesia and Analgesia
W J Liu, J Wang, H Yang, H Y Wu
No abstract text is available yet for this article.
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Y R Li, X Ding, C Y Wang, D M Han
Objective: To investigate the sleep-related deglutition in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with sleep stage and cortical arousals. Methods: From December 2015 to September 2017, simultaneous polysomnography and pharyngeal pressure monitoring were performed in 23 adult patients with OSAHS, Mann-Whitney U test were employed to analyze the following parameters: (1) the relationship between arousal and deglutition; (2) the effect of sleep stage on deglutition; (3) The relationship between the frequency of deglutition and the severity of OSAHS...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Kazutaka Hosoda, Minako Motoishi, Takuya Kunimoto, Osamu Nishimura, Byulnim Hwang, Sumire Kobayashi, Shigenobu Yazawa, Makoto Mochii, Kiyokazu Agata, Yoshihiko Umesono
Planarians have established a unique body pattern along the anterior-posterior (AP) axis, which consists of at least four distinct body regions arranged in an anterior to posterior sequence: head, prepharyngeal, pharyngeal (containing a pharynx), and tail regions, and possess high regenerative ability. How they reconstruct the regional continuity in a head-to-tail sequence after amputation still remains unknown. We use as a model planarian Dugesia japonica head regeneration from tail fragments, which involves dynamic rearrangement of the body regionality of preexisting tail tissues along the AP axis, and show here that RNA interference of the gene D...
June 13, 2018: Development, Growth & Differentiation
Dhanya Dharmapalan, Francis Yesurajan Inbanathan, Suhas Kharche, Asmita Patil, Shrikrishna Joshi, Vijay Yewale, Jones Lionel Kumar Daniel, Kamini Walia, Balaji Veeraraghavan
Streptococcus pyogenes , belonging to group A streptococcus (GAS), causes over 600 million infections annually being a predominant human pathogen. Lack of genomic data on GAS from India is one limitation to understand its virulence and antimicrobial resistance determinants. The genome of GAS isolates from clinical samples collected at Navi Mumbai, India was sequenced and annotated. Sequencing was performed on Ion Torrent PGM platform. The size of annotated S. pyogenes genomes ranged from ~1.69 to ~1.85 Mb with coverage of 38× to 189×...
June 2018: Data in Brief
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