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https://www.readbyqxmd.com/read/28088492/pikuni-blackfeet-traditional-medicine-neuroprotective-activities-of-medicinal-plants-used-to-treat-parkinson-s-disease-related-symptoms
#1
Aurélie de Rus Jacquet, Mitali Arun Tambe, Sin Ying Ma, George P McCabe, Jay Hansford C Vest, Jean-Christophe Rochet
ETHNOPHARMACOLOGICAL RELEVANCE: Parkinson's disease (PD) is a multifactorial neurodegenerative disorder affecting 5% of the population over the age of 85 years. Current treatments primarily involve dopamine replacement therapy, which leads to temporary relief of motor symptoms but fails to slow the underlying neurodegeneration. Thus, there is a need for safe PD therapies with neuroprotective activity. In this study, we analyzed contemporary herbal medicinal practices used by members of the Pikuni-Blackfeet tribe from Western Montana to treat PD-related symptoms, in an effort to identify medicinal plants that are affordable to traditional communities and accessible to larger populations...
January 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28078783/new-propolis-type-from-northeast-brazil-chemical-composition-antioxidant-activity-and-botanical-origin
#2
Joselena M Ferreira, Caroline C Fernandes-Silva, Antonio Salatino, Giuseppina Negri, Dejair Message
BACKGROUND: Propolis is a bee product with wide diversity of biological activity. It has complex composition, which is dependent on its botanical source. The present work aimed at determining the chemical profile, antioxidant activity and botanical origin of two samples of a propolis type from two locations of the state of Rio Grande do Norte (RN, northeast Brazil). RESULTS: The standard chemical characteristics of the RN propolis are similar or superior to the internationally marketed Brazilian green propolis...
January 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28077761/on-the-autorotation-of-animal-wings
#3
Victor Manuel Ortega-Jimenez, Antonio Martín-Alcántara, Ramon Fernandez-Feria, Robert Dudley
Botanical samaras spin about their centre of mass and create vertical aerodynamic forces which slow their rate of descent. Descending autorotation of animal wings, however, has never been documented. We report here that isolated wings from Anna's hummingbirds, and also from 10 species of insects, can stably autorotate and achieve descent speeds and aerodynamic performance comparable to those of samaras. A hummingbird wing loaded at its base with the equivalent of 50% of the bird's body mass descended only twice as fast as an unloaded wing, and rotated at frequencies similar to those of the wings in flapping flight...
January 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28076653/recent-advances-in-primate-nutritional-ecology
#4
Nicoletta Righini
Nutritional ecology seeks to explain, in an ecological and evolutionary context, how individuals choose, acquire, and process food to satisfy their nutritional requirements. Historically, studies of primate feeding ecology have focused on characterizing diets in terms of the botanical composition of the plants consumed. Further, dietary studies have demonstrated how patch and food choice in relation to time spent foraging and feeding are influenced by the spatial and temporal distribution of resources and by social factors such as feeding competition, dominance, or partner preferences...
January 11, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28076407/medicinal-plant-diversity-and-inter-cultural-interactions-between-indigenous-guarani-criollos-and-polish-migrants-in-the-subtropics-of-argentina
#5
Monika Kujawska, Norma I Hilgert, Héctor A Keller, Guillermo Gil
Numerous studies highlight the importance of phytotherapy for indigenous and non-indigenous people in different parts of the world. In this work we analyze the richness (number of species), diversity (plant identity and the number of illnesses for which it is used) and similarity of plant species and illnesses treated with them, in order to contribute new data and insight into the importance of plant medicines to the local medical systems of people living in Misiones province, in the subtropics of Argentina...
2017: PloS One
https://www.readbyqxmd.com/read/28075584/review-of-medicinal-and-aromatic-plants-industrial-profiles-volume-48-sesame-the-genus-sesamum-medicinal-and-aromatic-plants-industrial-profiles-volume-48-sesame-the-genus-sesamum-edited-by-d-bedigian-missouri-botanical-garden-st-louis-missouri-crc-press-taylor
#6
https://www.readbyqxmd.com/read/28068355/a-methodology-for-cancer-therapeutics-by-systems-pharmacology-based-analysis-a-case-study-on-breast-cancer-related-traditional-chinese-medicines
#7
Yan Li, Jinghui Wang, Feng Lin, Yinfeng Yang, Su-Shing Chen
Breast cancer is the most common carcinoma in women. Comprehensive therapy on breast cancer including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effect and resistance against anticancer drugs. Complementary and alternative medicine (CAM) may avoid these problems, in which traditional Chinese medicine (TCM) has been highlighted. In this section, to analyze the mechanism through which TCM act on breast cancer, we have built a virtual model consisting of the construction of database, oral bioavailability prediction, drug-likeness evaluation, target prediction, network construction...
2017: PloS One
https://www.readbyqxmd.com/read/28068280/landolphia-owariensis-attenuates-alcohol-induced-cerebellar-neurodegeneration-significance-of-neurofilament-protein-alteration-in-the-purkinje-cells
#8
Charles A Oyinbo, Patrick S Igbigbi, Godwin O Avwioro
BACKGROUND: Alcohol-induced cerebellar neurodegeneration is a neuroadaptation that is associated with chronic alcohol abuse. Conventional drugs have been largely unsatisfactory in preventing neurodegeneration. Yet, multimodal neuro-protective therapeutic agents have been hypothesised to have high therapeutic potential for the treatment of CNS conditions; there is yet a dilemma of how this would be achieved. Contrarily, medicinal botanicals are naturally multimodal in their mechanism of action...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28067513/evolution-of-quantitative-measures-in-nmr-quantum-mechanical-qhnmr-advances-chemical-standardization-of-a-red-clover-trifolium-pratense-extract
#9
Rasika S Phansalkar, Charlotte Simmler, Jonathan Bisson, Shao-Nong Chen, David C Lankin, James B McAlpine, Matthias Niemitz, Guido F Pauli
Chemical standardization, along with morphological and DNA analysis ensures the authenticity and advances the integrity evaluation of botanical preparations. Achievement of a more comprehensive, metabolomic standardization requires simultaneous quantitation of multiple marker compounds. Employing quantitative (1)H NMR (qHNMR), this study determined the total isoflavone content (TIfCo; 34.5-36.5% w/w) via multimarker standardization and assessed the stability of a 10-year-old isoflavone-enriched red clover extract (RCE)...
January 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28062287/potential-use-of-cuminic-acid-as-a-botanical-fungicide-against-valsa-mali
#10
Yong Wang, Yang Sun, LiRong Han, Xing Zhang, Juntao Feng
Valsa canker caused by Valsa mali is commonly present in eastern Asia and cause large economic losses. Because of limited agricultural measures and chemical residues of commonly used fungicides there is an urgent need of alternative plant protecting agents. On this background the activity of cuminic acid, a plant extract from the seed of Cuminum cyminum L, was assessed. The median effective concentration (EC50) values for inhibition of mycelial growth of seven V. mali strains ranged from 3.046 to 8.342 μg/mL, with an average EC50 value of 4...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28058460/-risk-assessment-of-synephrine-in-dietary-supplements
#11
Nadiya Bakhyia, Birgit Dusemund, Klaus Richter, Oliver Lindtner, Karen Ildico Hirsch-Ernst, Bernd Schäfer, Alfonso Lampen
Synephrine is a sympathomimetic phenylethylamine derivative that occurs naturally in citrus fruits. It is often added to dietary supplements intended for weight loss and enhancement of sports performance, typically in the form of Citrus aurantium extracts and in many cases in combination with caffeine. The health risks of synephrine were evaluated on the basis of the available toxicological data and in accordance to the EFSA guidance on the safety assessment of botanicals and botanical preparations intended for use in food supplements...
January 5, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28055331/review-of-ginkgo-biloba-induced-toxicity-from-experimental-studies-to-human-case-reports
#12
Nan Mei, Xiaoqing Guo, Zhen Ren, Daisuke Kobayashi, Keiji Wada, Lei Guo
Ginkgo biloba has been used as a traditional herbal remedy for many thousand years and its leaf extract has been consumed as a botanical dietary supplement for decades. Ginkgo biloba extract is a complex mixture with numerous components, including flavonol glycosides and terpene lactones, and is one of the most widely sold botanical dietary supplements worldwide. Concerns about potential health risks for the general population have been raised because of the widespread human exposure to Ginkgo biloba and its potential toxic and carcinogenic activities in rodents...
January 5, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28050136/a-user-s-guide-to-cannabinoid-therapies-in-oncology
#13
REVIEW
V Maida, P J Daeninck
"Cannabinoid" is the collective term for a group of chemical compounds that either are derived from the Cannabis plant, are synthetic analogues, or occur endogenously. Although cannabinoids interact mostly at the level of the currently recognized cannabinoid receptors, they might have cross reactivity, such as at opioid receptors. Patients with malignant disease represent a cohort within health care that have some of the greatest unmet needs despite the availability of a plethora of guideline-driven disease-modulating treatments and pain and symptom management options...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28048941/nematicidal-activity-of-trans-2-hexenal-against-southern-root-knot-nematode-meloidogyne-incognita-on-tomato-plants
#14
Hongbao Lu, Shuangyu Xu, Wenjuan Zhang, Chunmei Xu, Beixing Li, Daxia Zhang, Wei Mu, Feng Liu
Botanical nematicides have recently received increasing interest because of the high risks of some traditional nematicides to human health and the environment. This study evaluated the nematicidal activity of a plant volatile, trans-2-hexenal, against Meloidogyne incognita. This compound exhibited higher activity in a fumigation experiment than in the aqueous phase in vitro. Both in pot tests and in field trials, trans-2-hexenal showed significant efficacy against M. incognita while maintaining excellent plant growth, especially at doses of 1000 and 500 L ha(-1), which were superior to that of abamectin at 180 g ha(-1) via hole application treatment but not significantly different from fumigation with 400 kg ha(-1) of dazomet...
January 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28046004/species-diversity-effects-on-productivity-persistence-and-quality-of-multispecies-swards-in-a-four-year-experiment
#15
Jingying Jing, Karen Søegaard, Wen-Feng Cong, Jørgen Eriksen
Plant species diversity may benefit natural grassland productivity, but its effect in managed grassland systems is not well understood. A four-year multispecies grassland experiment was conducted to investigate the effect of species diversity-legumes and non-leguminous forbs-on productivity, persistence and sward quality under cutting or grazing regimes and with or without slurry application. Three mixtures were established- 3-mix: grass, red and white clover, 10-mix: 3-mix plus birdsfoot trefoil and six non-leguminous forbs, and 12-mix: 10-mix plus lucerne and festulolium...
2017: PloS One
https://www.readbyqxmd.com/read/28043897/natural-products-against-alzheimer-s-disease-pharmaco-therapeutics-and-biotechnological-interventions
#16
REVIEW
Abhijit Dey, Raktim Bhattacharya, Anuradha Mukherjee, Devendra Kumar Pandey
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease associated with memory and cognition impairment ultimately leading to death. It is the commonest reason of dementia in elderly populations mostly affecting beyond the age of 65. The pathogenesis is indicated by accumulation of the amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFT) in brain tissues and hyperphosphorylation of tau protein in neurons. The main cause is considered to be the formation of reactive oxygen species (ROS) due to oxidative stress...
December 30, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/28042768/blood-serum-atherogenicity-cellular-test-for-the-development-of-anti-atherosclerotic-therapy
#17
Veronika A Myasoedova, Galina A Ivashinnikova, Igor A Sobenin, Ekaterina A Ivanova, Alexander N Orekhov
Atherosclerosis is one of the main problems in modern medical practice. This multifactorial disease can remain asymptomatic for a long time before manifesting itself in cardiovascular disorders, causing ischemic heart disease, myocardial infarction and even sudden death. Many synthetic drugs have been developed to reduce the symptoms of atherosclerosis, however, their efficacy in terms of reduction of atherosclerotic lesions progression is a matter of debate. Adverse effects of the exiting therapy should also be taken into account...
January 2, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28038955/traditional-chinese-medicine-for-pulmonary-fibrosis-therapy-progress-and-future
#18
REVIEW
Liu-Cheng Li, Lian-Di Kan
ETHNOPHARMACOLOGICAL RELEVANCE: Pulmonary fibrosis (PF) is a chronic, debilitating and often lethal lung disorder. Despite the molecular mechanisms of PF are gradually clear with numerous researchers' efforts, few effective drugs have been developed to reverse human PF or even halt the chronic progression to respiratory failure. Traditional Chinese medicine (TCM), the main component of the medical practice used for more than 5000 years especially in China, often exerts wider action spectrum than previously attempted options in treating human diseases...
December 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28032819/optimizations-of-particle-size-and-pulp-density-for-solubilization-of-rock-phosphate-by-a-microbial-consortium-from-activated-sludge
#19
Chunqiao Xiao, Xiaoyan Wu, Tingting Liu, Guang Xu, Ruan Chi
Microbial solubilization of rock phosphate is getting more and more attention recently. However, the microorganisms used in previous studies were mostly single or known species, and seldom studies focused on the mixed microorganisms or microbial consortia from natural environments. In this study, a microbial consortium taken from activated sludge was used to solubilize two different mid-low grade rock phosphates. Results showed that the microbial consortium could effectively solubilize the rock phosphates in National Botanical Research Institute's phosphate growth medium and released soluble phosphorus in the broth...
December 29, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28032362/prioritizing-pharmacokinetic-drug-interaction-precipitants-in-natural-products-application-to-oatp-inhibitors-in-grapefruit-juice
#20
Emily J Johnson, Christina S Won, Kathleen Köeck, Mary F Paine
Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co-consumption with conventional drugs, raising concerns for unwanted natural product-drug interactions. Assessing the drug interaction liability of natural products is challenging due to the complex and variable chemical composition inherent to these products, necessitating a streamlined preclinical testing approach to prioritize precipitant individual constituents for further investigation...
December 29, 2016: Biopharmaceutics & Drug Disposition
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