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https://www.readbyqxmd.com/read/29144983/albumin-coordinated-assembly-of-clearable-platinum-nanodots-for-photo-induced-cancer-theranostics
#1
Yong'an Tang, Tao Yang, Qiaoli Wang, Xiaoyan Lv, Xue Song, Hengte Ke, Zhengqing Guo, Xiaoqing Huang, Jun Hu, Zifu Li, Peng Yang, Xiangliang Yang, Huabing Chen
Photoactive noble metal nanoparticles are of increasing importance toward personalized cancer therapy in the field of precision nanomedicine. A critical challenge remains in the exploration of clinically potential noble metal nanoparticles for highly efficient cancer theranostics. Here, we introduce albumin-coordinated assembly of clearable Pt nanodots (Pt-NDs) with monodisperse nanostructure as high-performance theranostic agents for imaging-guided photothermal tumor ablation. We precisely manipulate the reduction and growth of tetravalent Pt ions into ultrasmall nanodots through albumin-directed growth kinetics, thereby leading to the synthesis of monodisperse 6...
October 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/29144399/dna-g-wire-formation-using-an-artificial-peptide-is-controlled-by-protease-activity
#2
Kenji Usui, Arisa Okada, Shungo Sakashita, Masayuki Shimooka, Takaaki Tsuruoka, Shu-Ichi Nakano, Daisuke Miyoshi, Tsukasa Mashima, Masato Katahira, Yoshio Hamada
The development of a switching system for guanine nanowire (G-wire) formation by external signals is important for nanobiotechnological applications. Here, we demonstrate a DNA nanostructural switch (G-wire <--> particles) using a designed peptide and a protease. The peptide consists of a PNA sequence for inducing DNA to form DNA-PNA hybrid G-quadruplex structures, and a protease substrate sequence acting as a switching module that is dependent on the activity of a particular protease. Micro-scale analyses via TEM and AFM showed that G-rich DNA alone forms G-wires in the presence of Ca(2+), and that the peptide disrupted this formation, resulting in the formation of particles...
November 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29143476/differences-in-innervated-neurons-of-the-internal-anal-sphincter-based-on-age-and-sex-a-histological-study
#3
Tomoaki Kaneko, Tetsuo Nemoto, Kimihiko Funahashi, Junichi Koike, Kazutoshi Shibuya, Hironori Kaneko
AIM: Previous studies have shown sex and age differences in anal sphincter function, but few morphological studies have focused on the quality and quantity of the nerves that control the sphincter muscles. The present study aimed to determine whether there are morphological and quantitative sex and age differences in the nerves in the conjoined longitudinal muscle. METHODS: This was a single-center, retrospective study using surgical specimens from 44 patients who underwent abdominoperineal resection between 2003 and 2012...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29142188/a-case-of-microscopic-polyangiitis-with-subarachnoid-hemorrhage-and-cardiovascular-complications
#4
Sae Aratani, Yukinao Sakai, Shuichi Tsuruoka
Microscopic polyangiitis (MPA) is a primary systemic vasculitis that predominantly affects small and medium vessels. MPA is rarely complicated with central nervous system or cardiovascular disease. We report a very rare case of MPA complicated with cerebral infarction, cardiovascular disease, and fatal subarachnoid hemorrhage in a 54-year-old man. During the first six days of hospitalization the patient was diagnosed with rapid progressive glomerulonephritis (RPGN), cerebral infarction, and unstable angina...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29141714/falciparum-malaria-outbreak-in-sabah-linked-to-an-immigrant-rubber-tapper
#5
Saffree Mohammad Jeffree, Kamruddin Ahmed, Nazarudin Safian, Rohaizat Hassan, Omar Mihat, Khamisah Awang Lukman, Shamsul Bahari Shamsudin, Fadzilah Kamaludin
Sabah is a Malaysian state situated in the northern part of Borneo, and it is endemic for malaria. The incidence of malaria is the lowest (0.05/1,000 population) in Penampang districts of Sabah. In June 26, 2012, two Plasmodium falciparum malaria cases were notified to public health department from a village in Penampang. Immediate investigation was initiated to identify the risk factors and to institute control measures. We performed active case finding by asking household members of all houses in the village regarding malaria symptoms and by examining blood smears...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141684/bioinformatics-prediction-of-mir-30a-targets-and-its-inhibition-of-cell-proliferation-of-osteosarcoma-by-up-regulating-the-expression-of-pten
#6
Biao Zhong, Shang Guo, Wei Zhang, Chi Zhang, Yukai Wang, Changqing Zhang
BACKGROUND: MiRNAs are frequently abnormally expressed in the progression of human osteosarcoma. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is one of the tumor suppressors in various types of human cancer. In the present study, we detected how hsa-miR-30a-3p regulated PTEN and further tested the role of hsa-miR-30a-3p in the cell proliferation of osteosarcoma cells. METHODS: The levels of miR-30a were determined by real time PCR. The expression of PTEN was tested by western blotting analysis...
November 15, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29141549/a-high-throughput-quantitative-expression-analysis-of-cancer-related-genes-in-human-hepg2-cells-in-response-to-limonene-a-potential-anticancer-agent
#7
Rand R Hafidh, Saba Z Hussein, Mohammed Q MalAllah, Ahmed S Abdulamir, Fatimah Abu Bakar
BACKGROUND: Citrus bioactive compounds, as active anticancer agent, have been under focus by several studies worldwide. However, the underlying genes responsible for the anticancer potential have not been sufficiently highlighted. OBJECTIVES: The current study investigated the gene expression profile of hepatocellular carcinoma, HepG2, cells after treatment with Limonene. METHODS: The concentration that killed 50% of HepG2 cells was used to elucidate the genetic mechanisms of limonene anticancer activity...
November 14, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29141547/cardioprotective-effects-of-serca2a-overexpression-against-ischemia-reperfusion-induced-injuries-in-rats
#8
Yan Jian, Li-Li Tian, Lin-Hui Wang, Xiao-Dong Zhao, Jing-Wei Chen, Koji Murao, Wei Zhu, Liang Dong, Guo-Qing Wang, Wan-Ping Sun, Guo-Xing Zhang
AIMS: The aim of the present study is to assess how genetically increased Sarcoplasmic reticulum Ca2+-ATPase (Serca2a) expression affects cardiac injury after ischemia/reperfusion (I/R) exposure and the related mechanisms involved. METHODS AND RESULTS: Rats were subjected to left anterior descending coronary artery (LAD) occlusion for 30 min followed by a 24-hour reperfusion. Cardiac function analysis revealed that cardiac function dramatically improved in Serca2a transgenic rats (Serca2aTG) rats compared to wild type (WT) rats...
November 10, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/29141184/unrecognized-venous-injuries-after-cardiac-implantable-electronic-device-transvenous-lead-extraction
#9
Khaldoun G Tarakji, Walid Saliba, Danny Markabawi, E Rene Rodriguez, Yoaav Krauthammer, Michael P Brunner, Ayman A Hussein, Bryan Baranowski, Daniel J Cantillon, Mohamed Kanj, Mark Niebauer, Jack Rickard, Thomas Callahan, Mingyuan Shao, David O Martin, Oussama M Wazni, Bruce L Wilkoff, Carmela D Tan
BACKGROUND: Major complication rate of transvenous lead extraction (TLE) is estimated around 1-2.0%. Laceration of the central veins can be fatal. OBJECTIVES: to define the incidence and extent of venous injuries on a microscopic level after TLE and compare it with the incidence of clinically documented events of venous laceration. METHODS: We studied all patients who underwent TLE at our tertiary center within 30 months via a variety of techniques...
November 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29141071/usefulness-of-total-12-lead-qrs-voltage-as-a-clue-to-diagnosis-of-patients-with-cardiac-sarcoidosis-severe-enough-to-warrant-orthotopic-heart-transplant
#10
William C Roberts, Tiffany M Becker, Shelley A Hall
Importance: Severe heart failure caused by cardiac sarcoidosis is difficult to diagnosis without biopsy. Objective: To assess whether total electrocardiographic 12-lead QRS voltage may be a clue to diagnosis. Design, Setting, Participants: Case-series study with cases collected at Baylor University Medical Center at Dallas, Dallas, Texas, from January 13, 2005, to January 24, 2017. The clinical records of 16 patients with severe heart failure caused by cardiac sarcoidosis were studied...
November 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29141018/evaluation-of-the-proliferation-marker-ki-67-in-a-large-prostatectomy-cohort
#11
Elin Richardsen, Sigve Andersen, Samer Al-Saad, Mehrdad Rakaee, Yngve Nordby, Mona Irene Pedersen, Nora Ness, Thea Grindstad, Ingeborg Movik, Tom Dønnem, Roy Bremnes, Lill-Tove Busund
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to assess Ki-67 expression and related outcomes of 535 patients treated with radical prostatectomy. The percentage of tumor epithelial cells expressing Ki-67 was determined by immunohistochemical assay, both digital image analysis and visual scoring by light microscope were used for quantification...
2017: PloS One
https://www.readbyqxmd.com/read/29140318/electron-induced-photon-emission-above-the-quantum-cutoff-due-to-time-energy-uncertainty
#12
E Ekici, P Kapitza, C A Bobisch, R Möller
The light emission from a tunneling junction induced by tunneling electrons has been studied around the cutoff at hν=eVt. The emitted photons are found to exceed the excitation energy provided by the energy of the tunneling electrons. The experiments have been performed by a low- temperature scanning tunneling microscope at 80 K for an Ag(111) surface and an Ag-covered PtIr tip. A detailed analysis of the emission spectra reveals that the findings cannot be explained by the thermal broadening of the electron Fermi distribution alone...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29138708/chondroma-of-the-bladder-an-atypical-localization
#13
M Tamayo-Jover, A Nazco-Deroy, R González-Álvarez, H Álvarez-Argüelles Cabrera, B Padilla-Fernández, T Concepción-Masip
Chondroma is a benign tumour of mesenchymal origin that is composed of cartilage and rarely located in soft tissues, being described so far only in four cases, as located in the bladder, according to our knowledge. We describe the fifth case of a 67-year-old woman who consulted for microscopic haematuria, with an endoscopic finding of submucosal nodular image in the anterior wall of the bladder, which after resection and the histologic study shows cartilage and fibroconnective tissue, in part hyalinised, and positive immunohistochemical staining of cells with vimentin and S-100; this fact can support the diagnosis of bladder chondroma...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/29138019/a-patient-with-severe-fever-with-thrombocytopenia-syndrome-and-hemophagocytic-lymphohistiocytosis-associated-involvement-of-the-central-nervous-system
#14
Kaneko Masahiko, Shikata Hisaharu, Matsukage Shoichi, Maruta Masaki, Shinomiya Hiroto, Suzuki Tadaki, Hasegawa Hideki, Shimojima Masayuki, Saijo Masayuki
Severe fever with thrombocytopenia syndrome (SFTS), a severe infectious disease caused by novel bunyavirus, SFTS virus (SFTSV), is endemic to China, Korea, and Japan. Most SFTS patients show abnormalities in consciousness. Pathological findings in the central nervous system (CNS) of SFTS patients are not reported. A 53-year-old Japanese man was admitted to Uwajima City Hospital with an 8-day history of fever and diarrhea. Laboratory tests revealed leukopenia, thrombocytopenia, and liver enzyme elevation. He was diagnosed as having severe fever with thrombocytopenia syndrome (SFTS) following detection of the SFTSV genome in his blood...
November 11, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29137133/reduced-graphene-oxide-on-nickel-foam-for-supercapacitor-electrodes
#15
Uma Ramabadran, Gillian Ryan, Xuan Zhou, Susan Farhat, Felicia Manciu, Yigang Tong, Ryan Ayler, Graham Garner
The focus of this paper is the investigation of reduced graphene oxide (GO)/nickel foam (RGON) samples for use as supercapacitor electrodes. Nickel foam samples were soaked in a GO suspension and dried before being subjected to two different methods to remove oxygen. Atmospheric pressure annealed (APA) samples were treated with a varying number (10-18) of nitrogen plasma jet scans, where sample temperatures did not exceed 280 °C. Furnace annealed (FA) samples were processed in an atmosphere of hydrogen and argon, at temperatures ranging from 600 °C to 900 °C...
November 11, 2017: Materials
https://www.readbyqxmd.com/read/29137027/morphobiochemical-diagnosis-of-acute-trabecular-microfractures-using-gamma-correction-tc-99m-hdp-pinhole-bone-scan-with-histopathological-verification
#16
Yong-Whee Bahk, Seok-Ha Hwang, U-Young Lee, Yong-An Chung, Joo-Young Jung, Hyeonseok S Jeong
We prospectively performed gamma correction pinhole bone scan (GCPBS) and histopathologic verification study to make simultaneous morphobiochemical diagnosis of trabecular microfractures (TMF) occurred in the femoral head as a part of femoral neck fracture.Materials consisted of surgical specimens of the femoral head in 6 consecutive patients. The specimens were imaged using Tc-99m hydroxymethylene diphosphonate (HDP) pinhole scan and processed by the gamma correction. After cleansing with 10% formalin solution, injured specimen surface was observed using a surgical microscope to record TMF...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135880/histological-osteoarthritic-changes-in-the-human-cervical-spine-facet-joints-related-to-age-and-gender
#17
Lars Uhrenholt, Annie Vesterby Charles, Markil Gregersen, Jan Hartvigsen, Ellen-Margrethe Hauge
STUDY DESIGN: Cross-sectional autopsy study. OBJECTIVE: Quantify histological changes in the lower cervical spine facet joints with regard to age and gender using systematic random sampling of entire joints. SUMMARY OF BACKGROUND DATA: Neck pain is a common debilitating musculoskeletal condition and one of the highest ranked causes of years lived with disability. The cause of neck pain is multifactorial and osteoarthritis is one potential cause...
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29135278/acral-fibrokeratoma-a-rare-pedal-soft-tissue-mass
#18
Dyane E Tower, Jeffrey R Hammond
Acral fibrokeratoma (AF) is a rare soft tissue mass, more commonly found on the hands and rarely on the feet. This case report of a 40-year-old Hispanic male highlights an unusually located AF on the second toe, describes the clinical presentation, microscopic and pathologic findings, discusses differential diagnoses and presents treatment options.
November 14, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29135009/bacterial-species-identifiable-magnetic-nanosystems-for-early-sepsis-diagnosis-and-extracorporeal-photodynamic-blood-disinfection
#19
Jianhao Wang, Hao Wu, Yanmei Yang, Rong Yan, Yuan Zhao, Yanhao Wang, Aihong Chen, Shilong Shao, Pengju Jiang, Yong-Qiang Li
Despite the numerous bacteria detection and elimination techniques available nowadays, sensitive diagnosis and treatment of sepsis (caused by the presence of bacteria in the bloodstream), especially at the early stage, remain big challenges. Here we report a nanosystem for early sepsis diagnosis and complete extracorporeal blood disinfection, based on iron oxide magnetic nanoparticles functionalized with chlorin e6 molecules and bacterial species-identifiable aptamers (Fe3O4-Ce6-Apt). We demonstrate that the Fe3O4-Ce6-Apt nanosystem can achieve simultaneous blood bacterial species identification and enrichment in a single step, and the enriched bacteria can be easily detected with the assistance of fluorescence microscopic determination...
November 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29132724/emerging-entities-in-renal-cell-neoplasia-thyroid-like-follicular-renal-cell-carcinoma-and-multifocal-oncocytoma-like-tumours-associated-with-oncocytosis
#20
REVIEW
John N Eble, Brett Delahunt
The list of accepted entities of renal cell neoplasia has burgeoned since the turn of the century through recognition of rare tumour types and the discovery of genetic mutations driving renal neoplasia syndromes. This growth has not finished and in this report we present examples of each of these types which were not included in the 2016 World Health Organization classification of renal neoplasia, but are candidates for inclusion in the next edition of the classification. Thyroid-like follicular renal cell carcinoma is a rare tumour type with a distinctive microscopic appearance resembling follicles of the thyroid gland...
November 10, 2017: Pathology
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