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cancer and venous thromboembolism

Dominique Farge, Francis Cajfinger, Nicolas Falvo, Toufek Berremili, Francis Couturaud, Okba Bensaoula, Lionel Védrine, Hocine Bensalha, Isabelle Bonnet, Denis Péré-Vergé, Marie Coudurier, Veronique Li, Hanadi Rafii, Ilham Benzidia, Jean M Connors, Matthieu Resche-Rigon
Background: Clinical guidelines recommend at least 3-months low molecular weight heparin (LMWH) treatment for established venous thromboembolism (VTE) in cancer patients. However, no study has analyzed the impact of 3-6 months of LMWH therapy on quality-of-life (QoL) in cancer patients. Results: Among 400 cancer patients included at M0, 88.8% received long-term LMWH. Using a random-effects linear regression model with time as covariate, QoL scores in the MOS SF-36 (Global HRQoL, 1...
June 5, 2018: Oncotarget
Brian A Boone, Pranav Murthy, Jennifer Miller-Ocuin, W Reed Doerfler, Jarrod T Ellis, Xiaoyan Liang, Mark A Ross, Callen T Wallace, Jason L Sperry, Michael T Lotze, Matthew D Neal, Herbert J Zeh
BACKGROUND: The hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to substantial morbidity and mortality. Recently, neutrophil extracellular traps (NETs), whereby activated neutrophils release their intracellular contents containing DNA, histones, tissue factor, high mobility group box 1 (HMGB1) and other components have been implicated in PDA and in cancer-associated thrombosis. METHODS: Utilizing an orthotopic murine PDA model in C57/Bl6 mice and patient correlative samples, we studied the role of NETs in PDA hypercoagulability and targeted this pathway through treatment with the NET inhibitor chloroquine...
June 22, 2018: BMC Cancer
Y R Hu, Y Y Liu, L P Liu, H Zhang
This study aimed to observe the safety and effectiveness of different dosing regimens of low molecular weight heparin in the prevention of venous thromboembolism (VTE) and to provide a guideline for the treatment of individualized VTE prophylaxisin patients with postoperative gastrointestinal tumors. Forty patients with high risk for VTE after surgery for gastrointestinal tumors treated in Hongqi Hospital of Mudanjiang Medical University in the period October 2016 to May 2017 were included in the study. The patients were randomly divided into two groups, group A that included 24 patients treated with low molecular weight heparin (LMWH) 5000 IU every 12 hours, and group B comprised of 16 patients treated with LMWH 5000IU every 24 hours...
May 2018: Journal of Biological Regulators and Homeostatic Agents
Lara A Kahale, Maram B Hakoum, Ibrahim G Tsolakian, Charbel F Matar, Irene Terrenato, Francesca Sperati, Maddalena Barba, Victor Ed Yosuico, Holger Schünemann, Elie A Akl
BACKGROUND: Cancer increases the risk of thromboembolic events, especially in people receiving anticoagulation treatments. OBJECTIVES: To compare the efficacy and safety of low molecular weight heparins (LMWHs), direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) for the long-term treatment of venous thromboembolism (VTE) in people with cancer. SEARCH METHODS: We conducted a literature search including a major electronic search of the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE (Ovid), and Embase (Ovid); handsearching conference proceedings; checking references of included studies; use of the 'related citation' feature in PubMed and a search for ongoing studies in trial registries...
June 18, 2018: Cochrane Database of Systematic Reviews
Inna Tzoran, Ron Hoffman, Manuel Monreal
There is a growing proportion of the elderly population in the Western world, and these individuals require special considerations regarding a broad variety of aspects, including treatment approaches to illnesses that affect all age groups. The hemostatic system in individuals changes considerably with aging. Specifically, changes in levels of procoagulant and natural anticoagulant factors along with thrombopathy simultaneously create a hypercoagulable state and hemostatic difficulties. Underlying morbidities, such as congestive heart failure, chronic obstructive pulmonary disease, diabetes mellitus, and cancer, increase the risk for venous and arterial thrombosis...
June 19, 2018: Seminars in Thrombosis and Hemostasis
David Samuel, Gregory M Gressel, Sara Isani, Akiva P Novetsky, Nicole S Nevadunsky
Background: Venous thromboembolism after open gynecologic surgery is not uncommon, especially in the presence of other risk factors such as obesity, prolonged surgical time or gynecologic malignancy. Case: We present the case of a 62 y.o. patient who underwent open hysterectomy and surgical staging for uterine serous carcinoma. She was readmitted with lower extremity edema. During her workup, she underwent cardiovascular arrest secondary to saddle pulmonary embolus requiring cardiopulmonary resuscitation and extracorporeal membrane oxygenation...
May 2018: Gynecologic Oncology Reports
Iris Parrini, Irma Bisceglia
No abstract text is available yet for this article.
June 2018: Giornale Italiano di Cardiologia
Candice Ostrowka, Stéphanie Bonhomme, Pomme Jouffroy, Guillaume Riouallon
INTRODUCTION: Fractures of the pelvis (acetabulum and pelvic ring) are complex in both radiological diagnosis and therapeutic management. They show high risk of thrombosis, with variable rates of venous thromboembolic complications in the literature, ranging from 10% to 50%, with 0.5-10% risk of fatal pulmonary embolism. The objective of the present study was to determine the rate of venous thromboembolic events in a consecutive cohort of pelvic fracture and to attempt to identify thromboembolic risk factors in this population...
June 12, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Benjamin Bouyer, Annie Rudnichi, Rosemary Dray-Spira, Mahmoud Zureik, Joël Coste
BACKGROUND: Post-operative venous thromboembolism (VTE) is a severe complication, the risk of which after lumbar spine surgery (LBS) is not precisely known. OBJECTIVE: To estimate the incidence of VTE after LBS and to identify individual and surgical risk factors. METHODS: All patients over the age of 18 years who underwent LBS in France between 2009 and 2014 were identified. Among 477,024 patients screened, exclusions concerned recent VTE or surgery and multiple surgeries during the same hospital stay...
June 12, 2018: Journal of Thrombosis and Haemostasis: JTH
Ingrid Pabinger, Nick van Es, Georg Heinze, Florian Posch, Julia Riedl, Eva-Maria Reitter, Marcello Di Nisio, Gabriela Cesarman-Maus, Noémie Kraaijpoel, Christoph Carl Zielinski, Harry Roger Büller, Cihan Ay
BACKGROUND: Venous thromboembolism is a common complication of cancer, but the risk of developing venous thromboembolism varies greatly among individuals and depends on numerous factors, including type of cancer. We aimed to develop and externally validate a clinical prediction model for cancer-associated venous thromboembolism. METHODS: We used data from the prospective Vienna Cancer and Thrombosis Study (CATS) cohort (n=1423) to select prognostic variables for inclusion in the model...
June 6, 2018: Lancet Haematology
Timothy D Lyon, Matthew K Tollefson, Paras H Shah, Katherine Bews, Igor Frank, R Jeffrey Karnes, R Houston Thompson, Elizabeth B Habermann, Stephen A Boorjian
PURPOSE: To determine whether the rate of venous thromboembolism (VTE) following radical cystectomy (RC) is changing overtime. MATERIALS AND METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify patients who underwent RC for bladder cancer from 2011 to 2016. VTE was defined as pulmonary embolism or deep vein thrombosis within 30 days of RC. VTE rate by year was assessed using the Cochran-Armitage test for trend...
June 6, 2018: Urologic Oncology
Craig I Coleman, Alexander G G Turpie, Thomas J Bunz, Jan Beyer-Westendorf
A paucity of real-world data evaluating rivaroxaban in provoked venous thromboembolism (VTE) exists. We assessed the effectiveness and safety of rivaroxaban versus warfarin in provoked VTE patients treated in routine practice. Using MarketScan claims data from 1/2012 to 12/2016, we identified adults who had ≥ 1 primary hospitalization/emergency department discharge diagnosis code for VTE (index event) and a provoking factor, received rivaroxaban or warfarin as their first outpatient oral anticoagulant within 30-days of the index event and had ≥ 12-month of insurance coverage prior the index VTE...
June 7, 2018: Journal of Thrombosis and Thrombolysis
Aurélien Delluc, Mark Clemons
No abstract text is available yet for this article.
June 2, 2018: Thrombosis Research
Yasuhiko Ebina, Mihoko Uchiyama, Hitomi Imafuku, Kaho Suzuki, Yoshiya Miyahara, Hideto Yamada
We aim to clarify the incidence of deep venous thrombosis (DVT) before treatment in women with ovarian cancer and identify risk factors for DVT.In this prospective study, 110 women underwent venous ultrasonography before cancer treatment and D-dimer levels were measured. We investigated factors predicting DVT by logistic regression.DVT was detected in 25 of 110 women (22.7%) and pulmonary thromboembolism was coexisted in 2 women (1.8%). A total of 21 women (84.4%) with DVT were asymptomatic. D-dimer levels in women with DVT (median, 10...
June 2018: Medicine (Baltimore)
Naoya Yoshida, Yoshifumi Baba, Yuji Miyamoto, Masaaki Iwatsuki, Yukiharu Hiyoshi, Takatsugu Ishimoto, Yu Imamura, Masayuki Watanabe, Hideo Baba
BACKGROUND: The incidence of venous thromboembolism (VTE) after esophagectomy is higher than in other gastroenterological cancer surgery. Although the effectiveness and safety of thromboprophylaxis using enoxaparin have been established in orthopedic, abdominal, and pelvic surgeries, no studies regarding esophagectomy are available. METHODS: A prospective observational study was conducted to elucidate the usefulness of enoxaparin for VTE prophylaxis after esophagectomy...
June 6, 2018: Annals of Surgical Oncology
Sumeet Bhanvadia, Kayvan Kazerouni, Soroush T Bazargani, Gus Miranda, Jie Cai, Siamak Daneshmand, Hooman Djaladat
PURPOSE: To validate the relationship between ABO blood type and risk of VTE post-RC in a large retrospective database. METHODS: Patients with urothelial bladder cancer (UBC) who underwent RC (intent-to-cure) for whom ABO blood type was available between 2003 and 2015 were identified from our IRB-approved database. VTE was defined as deep vein thrombosis (DVT) or pulmonary embolism (PE) within 90 days of surgery. VTE prophylaxis consisted of immediate postoperative Coumadin (2003-2009), unfractionated heparin (UFH) during hospitalization (2009-2015), and UFH during hospitalization plus 4 weeks of enoxaparin after discharge (2013-2015)...
June 6, 2018: World Journal of Urology
Brian R Branchford, Shannon L Carpenter
Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT), and pulmonary embolism (PE), is becoming increasingly recognized as a cause of morbidity and mortality in pediatrics, particularly among hospitalized children. Furthermore, evidence is accumulating that suggests the inflammatory response may be a cause, as well as consequence, of VTE, but current anticoagulation treatment regimens are not designed to inhibit inflammation. In fact, many established clinical VTE risk factors such as surgery, obesity, cystic fibrosis, sepsis, systemic infection, cancer, inflammatory bowel disease, and lupus likely modulate thrombosis through inflammatory mediators...
2018: Frontiers in Pediatrics
Covadonga Gómez-Cuervo, Carmen Díaz-Pedroche, María Asunción Pérez-Jacoiste Asín, Antonio Lalueza, Roberto Del Pozo, Raquel Díaz-Simón, Francisco Trapiello, Diana Paredes, Carlos Lumbreras
Functional status linked to a poor outcome in a broad spectrum of medical disorders. Barthel Activities of Daily Life Index (BADLI) is one of the most extended tools to quantify functional dependence. Whether BADLI can help to predict outcomes in elderly patients with acute venous thromboembolism (VTE) is unknown. The current study aimed to ascertain the influence of BADLI on 6-month all-cause mortality in aged patients with VTE. This is a prospective observational study. We included consecutive patients older than 75-year-old with an acute VTE between April 2015 and April 2017...
June 5, 2018: Journal of Thrombosis and Thrombolysis
Yu-Jing Liang, Yan He, Jian-Mei Li, Lin-Min Chen, Li-Ping Chen, Cong Wang, Lu Ji, Zhen-Xiu Li, Lin-Quan Tang, Qiu-Yan Chen, Yu-Ying Fan, Wen Hu
Background: Despite wide usage, peripherally inserted central catheter (PICC)-related venous thromboembolism (VTE) is common in nasopharyngeal carcinoma (NPC) patients. Patients and methods: This was a retrospective cohort study of NPC patients with PICC insertions from February 2, 2007 to December 25, 2014 in Sun Yat-Sen University Cancer Centre. Univariable and multivariable logistic regression analyses were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the correlations between risk factors and symptomatic PICC-VTE...
2018: OncoTargets and Therapy
Marissa D Rybstein, Maria T DeSancho
Inherited and acquired thrombophilias and hypercoagulable states, such as active cancer, estrogen-induced, autoimmune disorders, major surgery, hospitalization, and trauma, are well-known risk factors for venous thromboembolism (VTE). The effect of these on recurrent VTE is different for each specific risk factor. The major risk factors affecting VTE recurrence include the presence of active cancer and an unprovoked first VTE. In addition, the use of combined female hormones in a woman with a previous history of estrogen-related VTE is a major risk factor for VTE recurrence...
June 2018: Seminars in Interventional Radiology
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