Angélica M Rosado-Quiñones, Emilee E Colón-Lorenzo, Zarna Rajeshkumar Pala, Jürgen Bosch, Karl Kudyba, Heather Kudyba, Susan E Leed, Norma Roncal, Abel Baerga-Ortiz, Abiel Roche-Lima, Yamil Gerena, David A Fidock, Alison Roth, Joel Vega-Rodríguez, Adelfa E Serrano
The development of novel antiplasmodial compounds with broad-spectrum activity against different stages of Plasmodium parasites is crucial to prevent malaria disease and parasite transmission. This study evaluated the antiplasmodial activity of seven novel hydrazone compounds (referred to as CB compounds: CB-27, CB-41, CB-50, CB-53, CB-58, CB-59, and CB-61) against multiple stages of Plasmodium parasites. All CB compounds inhibited blood stage proliferation of drug-resistant or sensitive strains of Plasmodium falciparum in the low micromolar to nanomolar range...
April 19, 2024: Antimicrobial Agents and Chemotherapy