keyword
MENU ▼
Read by QxMD icon Read
search

Johns Hopkins

keyword
https://www.readbyqxmd.com/read/28431425/the-association-of-frailty-with-outcomes-and-resource-use-after-emergency-general-surgery-a-population-based-cohort-study
#1
Daniel I McIsaac, Husein Moloo, Gregory L Bryson, Carl van Walraven
BACKGROUND: Older patients undergoing emergency general surgery (EGS) experience high rates of postoperative morbidity and mortality. Studies focused primarily on elective surgery indicate that frailty is an important predictor of adverse outcomes in older surgical patients. The population-level effect of frailty on EGS is poorly described. Therefore, our objective was to measure the association of preoperative frailty with outcomes in a population of older patients undergoing EGS. METHODS: We created a population-based cohort study using linked administrative data in Ontario, Canada, that included community-dwelling individuals aged >65 years having EGS...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28431334/one-hundred-injured-patients-a-day-multicenter-emergency-room-surveillance-of-trauma-in-pakistan
#2
A A Hyder, S He, W Zafar, M U Mir, J A Razzak
OBJECTIVES: Injuries increasingly contribute to the global burden of disease in low- and middle-income countries. This study presents results from a large-scale surveillance study on injury from several urban emergency departments (EDs) in Pakistan. The objective is to document the burden of injuries that present to the healthcare system in Pakistan and to test the feasibility of an ED-based injury and trauma surveillance system. STUDY DESIGN: Cross-sectional study conducted using active surveillance approach...
April 18, 2017: Public Health
https://www.readbyqxmd.com/read/28426586/predictive-modeling-of-massive-transfusion-requirements-during-liver-transplantation-and-its-potential-to-reduce-utilization-of-blood-bank-resources
#3
Aliaksei Pustavoitau, Maggie Lesley, Promise Ariyo, Asad Latif, April J Villamayor, Steven M Frank, Nicole Rizkalla, William Merritt, Andrew Cameron, Nabil Dagher, Benjamin Philosophe, Ahmet Gurakar, Allan Gottschalk
BACKGROUND: Patients undergoing liver transplantation frequently but inconsistently require massive blood transfusion. The ability to predict massive transfusion (MT) could reduce the impact on blood bank resources through customization of the blood order schedule. Current predictive models of MT for blood product utilization during liver transplantation are not generally applicable to individual institutions owing to variability in patient population, intraoperative management, and definitions of MT...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28419541/when-should-active-surveillance-for-prostate-cancer-stop-if-no-progression-is-detected
#4
Tiago M de Carvalho, Eveline A M Heijnsdijk, Harry J de Koning
BACKGROUND: A significant proportion of screen-detected men with prostate cancer may be overdiagnosed. Active Surveillance (AS) has emerged as a way to mitigate this problem, by delaying treatment of men, who are at low-risk until this becomes necessary. However, it is not known after how much time or biopsy rounds should patients stop AS and transition to conservative management (CM), if no progression is detected. METHODS: We used a microsimulation model with natural history of prostate cancer based on ERSPC and SEER data...
April 17, 2017: Prostate
https://www.readbyqxmd.com/read/28418761/economic-evaluation-of-a-hospital-based-palliative-care-program
#5
Sarina R Isenberg, Chunhua Lu, John McQuade, Rab Razzak, Brian W Weir, Natasha Gill, Thomas J Smith, David R Holtgrave
PURPOSE: Establish costs of an inpatient palliative care unit (PCU) and conduct a threshold analysis to estimate the maximum possible costs for the PCU to be considered cost effective. METHODS: We used a hospital perspective to determine costs on the basis of claims from administrative data from Johns Hopkins PCU between March 2013 and March 2014. Using existing literature, we estimated the number of quality-adjusted life years (QALYs) that the PCU could generate...
April 18, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28418739/the-joint-external-evaluation-of-taiwan-the-external-evaluators-perspective
#6
Eric S Toner, Jennifer B Nuzzo, Matthew Shearer, Crystal Watson, Tara Kirk Sell, Anita Cicero
A team of experts from the Johns Hopkins Center for Health Security conducted an independent external assessment of Taiwan's capabilities under the International Health Regulations 2005 (IHR), using the IHR Joint External Evaluation (JEE) tool adopted by the World Health Organization and the Global Health Security Agenda. In this article we describe the methods and process of the assessment, identify lessons learned, and make recommendations for the government of Taiwan, the JEE process, and the JEE tool.
March 2017: Health Security
https://www.readbyqxmd.com/read/28418719/the-incremental-validity-of-self-report-and-performance-based-methods-for-assessing-hostility-to-predict-cardiovascular-disease-in-physicians
#7
Gregory J Meyer, Nicholas J Katko, Joni L Mihura, Michael J Klag, Lucy A Meoni
We evaluated the utility of an integrative, multimethod approach for assessing hostility-related constructs to predict premature cardiovascular disease (CVD) and premature coronary heart disease (CHD) using participants from the Johns Hopkins Precursors Study, which was designed to identify risk factors for heart disease. Participants were assessed at baseline while in medical school from 1946 to 1962 (M age = 24.6) and have been followed annually since then. Baseline assessment included individually administered Rorschach protocols (N = 416) scored for aggressive imagery (i...
April 18, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28418539/ophthalmic-manifestations-of-congenital-zika-syndrome-in-colombia-and-venezuela
#8
Juan B Yepez, Felipe A Murati, Michele Pettito, Carlos F Peñaranda, Jazmin de Yepez, Gladys Maestre, J Fernando Arevalo
Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. In addition, confirmation whether the public health problem in Brazil extends to other regions in South America is needed...
April 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28417979/longitudinal-assessment-of-urinary-pca3-for-predicting-prostate-cancer-grade-reclassification-in-favorable-risk-men-during-active-surveillance
#9
J J Tosoian, H D Patel, M Mamawala, P Landis, S Wolf, D J Elliott, J I Epstein, H B Carter, A E Ross, L J Sokoll, C P Pavlovich
BACKGROUND: To assess the utility of urinary prostate cancer antigen 3 (PCA3) as both a one-time and longitudinal measure in men on active surveillance (AS). METHODS: The Johns Hopkins AS program monitors men with favorable-risk prostate cancer with serial PSA, digital rectal examination (DRE), prostate magnetic resonance imaging and prostate biopsy. Since 2007, post-DRE urinary specimens have also been routinely obtained. Men with multiple PCA3 measures obtained over ⩾3 years of monitoring were included...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28407623/fine-needle-aspiration-of-langerhans-cell-histiocytosis-a-cytopathologic-study-of-37-cases
#10
Jen-Fan Hang, Momin T Siddiqui, Syed Z Ali
OBJECTIVE: Langerhans cell histiocytosis (LCH) is an uncommon neoplasm of dendritic cells and predominantly occurs in children and young adults. The study aims to evaluate cytopathologic features and current diagnostic concepts in a large series of LCH on fine needle aspiration (FNA). STUDY DESIGN: We retrospectively searched the pathology archives of The Johns Hopkins Hospital (JHH) and Emory University Hospital (EUH) to identify all FNA cases diagnosed as LCH in a period of 21 years...
April 14, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28406713/an-observational-study-of-outcomes-and-tolerances-in-patients-with-cystic-fibrosis-initiated-on-lumacaftor-ivacaftor
#11
Mark T Jennings, Rebecca Dezube, Shruti Paranjape, Natalie E West, Gina Hong, Andrew Braun, Jonathan Grant, Christian A Merlo, Noah Lechtzin
RATIONALE: In July 2015, the FDA approved lumacaftor/ivacaftor for use in patients with CF. This drug targets the primary defect in the CFTR protein that is conferred by the F508del CFTR mutation. OBJECTIVE: As there is limited experience with this therapy outside of clinical trials, this study aims to examine the clinical experience of this new drug in a CF population. METHODS: Retrospective cohort study of individuals followed at the Johns Hopkins CF Center, who initiated treatment with lumacaftor/ivacaftor...
April 13, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28400898/many-neurology-readmissions-are-nonpreventable
#12
Sidney T Le, S Andrew Josephson, Hans A Puttgen, Lorrie Gibson, Elan L Guterman, Heather M Leicester, Carla L Graf, John C Probasco
INTRODUCTION: Reducing unplanned hospital readmissions has become a national focus due to the Centers for Medicare and Medicaid Services' (CMS) penalties for hospitals with high rates. A first step in reducing unplanned readmission is to understand which patients are at high risk for readmission, which readmissions are planned, and how well planned readmissions are currently captured in comparison to patient-level chart review. METHODS: We examined all 5455 inpatient neurology admissions over a 2-year period to University of California San Francisco Medical Center and Johns Hopkins Hospital via chart review...
April 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28400167/validation-of-a-genomic-risk-classifier-to-predict-prostate-cancer-specific-mortality-in-men-with-adverse-pathologic-features
#13
R Jeffrey Karnes, Voleak Choeurng, Ashley E Ross, Edward M Schaeffer, Eric A Klein, Stephen J Freedland, Nicholas Erho, Kasra Yousefi, Mandeep Takhar, Elai Davicioni, Matthew R Cooperberg, Bruce J Trock
BACKGROUND: Risk of prostate cancer-specific mortality (PCSM) is highly variable for men with adverse pathologic features at radical prostatectomy (RP); a majority will die of other causes. Accurately stratifying PCSM risk can improve therapy decisions. OBJECTIVE: Validate the 22 gene Decipher genomic classifier (GC) to predict PCSM in men with adverse pathologic features after RP. DESIGN, SETTING, AND PARTICIPANTS: Men with adverse pathologic features: pT3, pN1, positive margins, or Gleason score >7 who underwent RP in 1987-2010 at Johns Hopkins, Cleveland Clinic, Mayo Clinic, and Durham Veteran's Affairs Hospital...
April 8, 2017: European Urology
https://www.readbyqxmd.com/read/28398822/a-prdx1-specific-redox-regulation-of-the-novel-foxo3-mirna-target-let-7
#14
Barbara Lee Hopkins, Monica Nadler, John Skoko, Thierry Bertomeu, Andrea Pelosi, Parisa Mousavi-Shafaei, Kevin Levine, Anja Schempf, Bodvael Pennarun, Bo Yang, Dipak Datta, Steffi Oesterreich, Da Yang, Maria Giulia Rizzo, Roya Khoshravi-Far, Carola A Neumann
Precision in redox-signaling is in part attained through post-translational oxidation of protein thiols. Here, we uncover a redox-mechanism regulating the transcription factor FOXO3 in response to H2O2-stress through binding of the peroxidase peroxiredoxin 1 (PRDX1). Heightened oxidative stress evokes formation of reducible disulfide-bound heterotrimers linking dimeric PRDX1 to monomeric FOXO3. Notably, in contrast to wild-type FOXO3, FOXO3-cysteine mutants abrogate PRDX1 binding, show higher and constitutive FOXO3-T32 phosphorylation and display cytoplasmic retention under H2O2-stress that is reverted by PI3K inhibition...
February 22, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28397312/3lessons-from-the-cagi-4-hopkins-clinical-panel-challenge
#15
John-Marc Chandonia, Aashish Adhikari, Marco Carraro, Aparna Chhibber, Garry R Cutting, Yao Fu, Alessandra Gasparini, David T Jones, Andreas Kramer, Kunal Kundu, Hugo Y K Lam, Emanuela Leonardi, John Moult, Lipika R Pal, David B Searls, Sohela Shah, Shamil Sunyaev, Silvio C E Tosatto, Yizhou Yin, Bethany A Buckley
The CAGI-4 Hopkins clinical panel challenge was an attempt to assess state of the art methods for clinical phenotype prediction from DNA sequence. Participants were provided with exonic sequences of 83 genes for 106 patients from the Johns Hopkins DNA Diagnostic Laboratory. Five groups participated in the challenge, predicting both the probability that each patient had each of fourteen possible classes of disease, as well as one or more causal variants. In cases where the Hopkins laboratory reported a variant, at least one predictor correctly identified the disease class in 36 of 43 patients (84%)...
April 11, 2017: Human Mutation
https://www.readbyqxmd.com/read/28385023/impact-of-a-pharmacy-based-transitional-care-program-on-hospital-readmissions
#16
Weiyi Ni, Danielle Colayco, Jonathan Hashimoto, Kevin Komoto, Chandrakala Gowda, Bruce Wearda, Jeffrey McCombs
OBJECTIVES: Avoidable readmissions of patients discharged from hospitals are a major concern. This study evaluates the impact of pharmacist-provided postdischarge services on hospital readmissions for members of a US managed Medicaid health plan. STUDY DESIGN: Prospective cohort study. METHODS: Synergy Pharmacy Solutions (SPS) initiated a transition of care (TOC) service for high-risk members of the Kern Health Systems (KHS) managed Medicaid plan...
March 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28384888/perception-of-learning-environment-among-undergraduate-medical-students-in-two-different-medical-schools-through-dreem-and-jhles-questionnaire
#17
Parama Sengupta, Abhishek Sharma, Nina Das
INTRODUCTION: Assessment of learning environment is essential to assess the acceptability of the curriculum among students. Several tools are available to assess undergraduate medical students' perception of learning environment. Dundee Ready Education Environment Measure (DREEM) questionnaire is the most commonly used tool. Here, we have used both the widely used DREEM questionnaire and a relatively new questionnaire Johns Hopkins Learning Environment Scale (JHLES). AIM: Assessment of students' perception of learning environment of two eastern Indian medical schools using DREEM and JHLES questionnaire...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28379933/communities-social-justice-and-academic-health-centers
#18
Philip M Alberti, Karey M Sutton, Lisa A Cooper, Wendy G Lane, Stacey Stephens, Michelle A Gourdine
In November 2015, the Association of American Medical Colleges (AAMC) held its annual meeting in Baltimore, Maryland. In response both to health and health care inequities faced by residents of Baltimore and to the imminent trial of the police officers charged with Freddie Gray's death, AAMC leaders thought it crucial to address issues of health inequity, social injustice, and the role an academic health center (AHC) can play in improving the health of the community it serves. In collaboration with community-engaged researchers from Johns Hopkins University and University of Maryland, Baltimore, AAMC staff interviewed Baltimore residents, soliciting their perspectives on how medical education, clinical care, and research can and should respond to social injustice and the social determinants of health...
April 4, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28377864/open-door-laminoplasty-creation-of-a-new-vertebral-arch
#19
Monica Lara-Almunia, Javier Hernandez-Vicente
BACKGROUND: We describe the carrying out of our open door laminoplasty technique by reproducing a posterior vertebral arch using a local originating autologous bony graft and titanium plates. METHODS: We designed a prospective study and present our first 16 patients. The clinical results were evaluated with the JOA score, Nurick scale and the VAS. The functional and radiological evaluation was performed with radiographs, CT and MRI, and the measurements of the dimensions of the spinal canal were carried out with the MIPAV programme ( Johns Hopkins University)...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28359707/evidence-based-practice-video-discharge-instructions-in-the-pediatric-emergency-department
#20
Elyssa B Wood, Gina Harrison, Amber Trickey, Mary Ann Friesen, Sarah Stinson, Erin Rovelli, Serena McReynolds, Kristina Presgrave
While a high quality discharge from a Pediatric Emergency Department helps caregivers feel informed and prepared to care for their sick child at home, poor adherence to discharge instructions leads to unnecessary return visits, negative health outcomes, and decreased patient satisfaction. Nurses at the Inova Loudoun Pediatric ED utilized the Johns Hopkins Model of Evidence Based Practice to answer the following question: Among caregivers who have children discharged from the ED, does the addition of video discharge instructions (VDI) to standard written/verbal discharge instructions (SDI) result in improved knowledge about the child's diagnosis, treatment, illness duration, and when to seek further medical care? METHODS: A multidisciplinary team reviewed available evidence and created VDI for three common pediatric diagnoses: gastroenteritis, bronchiolitis, and fever...
March 28, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
keyword
keyword
39874
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"