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https://www.readbyqxmd.com/read/29776377/shifts-in-borrelia-burgdorferi-s-l-geno-species-infections-in-ixodes-ricinus-over-a-10-year-surveillance-period-in-the-city-of-hanover-germany-and-borrelia-miyamotoi-specific-reverse-line-blot-detection
#1
Katrin Blazejak, Marie-Kristin Raulf, Elisabeth Janecek, Daniela Jordan, Volker Fingerle, Christina Strube
BACKGROUND: Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health. The predominant vector in Europe is the widespread hard tick Ixodes ricinus, which also transmits the relapsing fever spirochete B. miyamotoi as well as pathogenic Rickettsiales (Anaplasma phagocytophilum, Rickettsia spp.). To assess the public health risk, a long-term monitoring of tick infection rates with the named pathogens is indispensable...
May 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29774138/clinical-evaluation-of-morgellons-disease-in-a-cohort-of-north-american-patients
#2
Melissa C Fesler, Marianne J Middelveen, Raphael B Stricker
Morgellons disease (MD) is a dermatological condition characterized by aberrant production of keratin and collagen fibers in skin. Although infection with Borrelia burgdorferi , the causative agent of Lyme disease (LD), has been associated with MD, relatively few studies have hitherto provided epidemiological evidence regarding this association. A cohort of 1000 seropositive North American LD patients was evaluated for the presence of MD. Patients were diagnosed with MD based on detection of microscopic fibers in skin lesions or under unbroken skin...
April 23, 2018: Dermatology Reports
https://www.readbyqxmd.com/read/29762516/seasonal-patterns-in-the-prevalence-and-diversity-of-tick-borne-borrelia-burgdorferi-sensu-lato-anaplasma-phagocytophilum-and-rickettsia-spp-in-an-urban-temperate-forest-in-south-western-slovakia
#3
Michal Chvostáč, Eva Špitalská, Radovan Václav, Tatiana Vaculová, Lenka Minichová, Markéta Derdáková
In Europe, Ixodes ricinus is the most important vector of tick-borne zoonotic bacteria. It transmits spirochaetes from the Borrelia burgdorferi sensu lato complex, Anaplasma phagocytophilum and Rickettsia spp. Although spatial differences in the prevalence of tick-borne pathogens have been intensively studied, seasonal (within-year) fluctuations in the prevalence of these pathogens within sites are often overlooked. We analyzed the occurrence and seasonal dynamics of Ixodes ricinus in an urban forest in Bratislava, Slovakia...
May 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29749010/borrelia-burgdorferi-surface-located-lmp1-protein-processed-into-region-specific-polypeptides-that-are-critical-for-microbial-persistence
#4
Xuran Zhuang, Xiuli Yang, Amanda S Altieri, Daniel C Nelson, Utpal Pal
One of the Borrelia burgdorferi virulence determinants, annotated as Lmp1, is a surface-exposed, conserved and potential multi-domain protein involved in various functions in spirochete infectivity. Lmp1 contributes to host-pathogen interactions and evasion of host adaptive immunity by spirochetes. Here we show that in diverse B. burgdorferi species, Lmp1 exists as distinct, region-specific and lower molecular mass polypeptides encompassing one or more domains, including independent N-terminal and middle regions and a combined middle and C-terminal region...
May 10, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29746581/human-neuroglial-cells-internalize-borrelia-burgdorferi-by-coiling-phagocytosis-mediated-by-daam1
#5
Shanna K Williams, Zachary P Weiner, Robert D Gilmore
Borrelia burgdorferi, the agent of Lyme borreliosis, can elude hosts' innate and adaptive immunity as part of the course of infection. The ability of B. burgdorferi to invade or be internalized by host cells in vitro has been proposed as a mechanism for the pathogen to evade immune responses or antimicrobials. We have previously shown that B. burgdorferi can be internalized by human neuroglial cells. In this study we demonstrate that these cells take up B. burgdorferi via coiling phagocytosis mediated by the formin, Daam1, a process similarly described for human macrophages...
2018: PloS One
https://www.readbyqxmd.com/read/29746483/efficient-detection-of-symptomatic-and-asymptomatic-patient-samples-for-babesia-microti-and-borrelia-burgdorferi-infection-by-multiplex-qpcr
#6
Shekerah Primus, Lavoisier Akoolo, Samantha Schlachter, Kristine Gedroic, Albert D Rojtman, Nikhat Parveen
BACKGROUND: Tick-borne infections have been increasing steadily over the years, with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem. B. burgdorferi is a spirochetal bacterium that causes Lyme disease while protozoan pathogens belonging to Babesia species are responsible for babesiosis. Currently used serological tests do not always detect acute Lyme disease or babesiosis, and fail to differentiate cured patients from those who get re-infected...
2018: PloS One
https://www.readbyqxmd.com/read/29738078/tick-borne-disease-risk-in-a-forest-food-web
#7
Richard S Ostfeld, Taal Levi, Felicia Keesing, Kelly Oggenfuss, Charles D Canham
Changes to the community ecology of hosts for zoonotic pathogens, particularly rodents, are likely to influence the emergence and prevalence of zoonotic diseases worldwide. However, the complex interactions between abiotic factors, pathogens, vectors, hosts, and both food resources and predators of hosts are difficult to disentangle. Here we (1) use 19 years of data from six large field plots in southeastern New York to compare the effects of hypothesized drivers of interannual variation in Lyme disease risk, including the abundance of acorns, rodents, and deer, as well as a series of climate variables; and (2) employ landscape epidemiology to explore how variation in predator community structure and forest cover influences spatial variation in the infection prevalence of ticks for the Lyme disease bacterium, Borrelia burgdorferi, and two other important tick-borne pathogens, Anaplasma phagocytophilum and Babesia microti...
May 8, 2018: Ecology
https://www.readbyqxmd.com/read/29723263/borrelia-burgdorferi-adhere-to-blood-vessels-in-the-dura-mater-and-are-associated-with-increased-meningeal-t-cells-during-murine-disseminated-borreliosis
#8
Ali Divan, Timothy Casselli, S Anand Narayanan, Sanjib Mukherjee, David C Zawieja, John A Watt, Catherine A Brissette, M Karen Newell-Rogers
Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. burgdorferi spirochetes. Although the NHP model parallels aspects of human borreliosis, a small rodent model would be ideal to study the trafficking of spirochetes and immune cells into the CNS...
2018: PloS One
https://www.readbyqxmd.com/read/29721281/effects-of-a-zoonotic-pathogen-borrelia-burgdorferi-on-the-behavior-of-a-key-reservoir-host
#9
Richard S Ostfeld, Dustin Brisson, Kelly Oggenfuss, Jill Devine, Michael Z Levy, Felicia Keesing
Most emerging infectious diseases of humans are transmitted to humans from other animals. The transmission of these "zoonotic" pathogens is affected by the abundance and behavior of their wildlife hosts. However, the effects of infection with zoonotic pathogens on behavior of wildlife hosts, particularly those that might propagate through ecological communities, are not well understood. Borrelia burgdorferi is a bacterium that causes Lyme disease, the most common vector-borne disease in the USA and Europe...
April 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29716838/low-probability-of-a-dilution-effect-for-lyme-borreliosis-in-belgian-forests
#10
Sanne C Ruyts, Dries Landuyt, Evy Ampoorter, Dieter Heylen, Steffen Ehrmann, Elena C Coipan, Erik Matthysen, Hein Sprong, Kris Verheyen
An increasing number of studies have investigated the consequences of biodiversity loss for the occurrence of vector-borne diseases such as Lyme borreliosis, the most common tick-borne disease in the northern hemisphere. As host species differ in their ability to transmit the Lyme borreliosis bacteria Borrelia burgdorferi s.l. to ticks, increased host diversity can decrease disease prevalence by increasing the proportion of dilution hosts, host species that transmit pathogens less efficiently. Previous research shows that Lyme borreliosis risk differs between forest types and suggests that a higher diversity of host species might dilute the contribution of small rodents to infect ticks with B...
April 22, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29716647/seroprevalence-of-borrelia-burgdorferi-in-belgian-forestry-workers-and-associated-risk-factors
#11
Mathilde De Keukeleire, Annie Robert, Victor Luyasu, Benoît Kabamba, Sophie O Vanwambeke
BACKGROUND: As forest is the preferred environment for ticks, forestry workers are exposed to tick bites and tick-borne diseases. We assessed the seroprevalence of anti-Borrelia burgdorferi (Bb) antibodies and investigated, using an integrated landscape approach, the individual and environmental factors associated with the seroprevalence of Bb in Belgian forestry workers, a high-risk group in Belgium. METHODS: A group of 310 Belgian forest workers was examined to assess the seroprevalence of anti-Borrelia IgG antibodies...
May 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29713635/detection-of-tick-borne-pathogens-in-lambs-undergoing-prophylactic-treatment-against-ticks-on-two-swedish-farms
#12
Giulio Grandi, Anna Aspán, Jenny Pihl, Katarina Gustafsson, Fredrik Engström, Tomas Jinnerot, Robert Söderlund, Jan Chirico
Tick-borne pathogens (TBPs), especially Anaplasma phagocytophilum , cause disease in grazing livestock. Tick prophylaxis is, therefore, a routine practice in sheep flocks in Sweden, especially in central, southern, and coastal areas of the country where ixodid ticks ( Ixodes ricinus and Haemaphysalis punctata ) are present. In the present study, the status of infection by A. phagocytophilum and other TBPs in lambs treated with tick prophylaxis has been assessed serologically and with polymerase chain reaction (PCR)...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29692913/first-report-of-coxiella-burnetii-and-borrelia-burgdorferi-sensu-lato-in-poultry-red-mites-dermanyssus-gallinae-mesostigmata-acari-related-to-urban-outbreaks-of-dermatitis-in-italy
#13
D A Raele, D Galante, N Pugliese, G La Salandra, M Lomuto, M Assunta Cafiero
The poultry red mite (PRM), Dermanyssus gallinae, is a nonburrowing haematophagous nest-dwelling ectoparasite of birds; occasionally it bites humans, inducing dermatitis. The possibility that this parasite may also be involved in transmission of pathogens is an additional concern. We investigated the presence of zoonotic agents in PRMs from bird nests and pets, and related them to urban outbreaks of dermatitis. A total of 98 PRMs from 12 outbreaks of PRM dermatitis that occurred in Italian cities from 2001 to 2017 were molecularly investigated for detection of Coxiella spp...
May 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29685985/-b-orrelia-host-ad-aptation-p-rotein-badp-is-required-for-the-colonization-of-a-mammalian-host-by-the-agent-of-lyme-disease
#14
Trever C Smith, Sarah M Helm, Yue Chen, Ying-Han Lin, S L Rajasekhar Karna, J Seshu
Borrelia burgdorferi ( Bb ), the agent of Lyme disease (LD), uses host-derived signals to modulate gene expression during the vector and mammalian phases of infection. Microarray analysis of mutants lacking <u>B</u>orrelia host-<u>ad</u>aptation <u>R</u>egulator (BadR) revealed down-regulation of genes encoding enzymes whose role in the patho-physiology of Bb is unknown. Immunoblot analysis of the badR mutants confirmed reduced levels of these enzymes and one of these enzymes encoded by bb0086 , shares homology to prokaryotic magnesium chelatase and Lon-type proteases...
April 23, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29680260/the-role-of-ixodes-scapularis-borrelia-burgdorferi-and-wildlife-hosts-in-lyme-disease-prevalence-a-quantitative-review
#15
REVIEW
Samniqueka J Halsey, Brian F Allan, James R Miller
Due to the ongoing expansion of Ixodes scapularis (blacklegged tick) throughout the northeastern and midwestern United States, there is need to identify the role wildlife hosts play in the establishment and maintenance of tick populations. To quantify and synthesize the patterns of I. scapularis and Borrelia burgdorferi sensu stricto and sensu lato prevalence relative to wildlife hosts, we reviewed the findings of independent studies conducted throughout the United States. We performed a comprehensive literature search from 1970 to 2017 using the ISS Web of Science Core Collection and the keywords "Ixodes scapularis," "Ixodes dammini" and "Borrelia burgdorferi...
April 16, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29678403/tick-borne-encephalitis-virus-borrelia-burgdorferi-sensu-lato-borrelia-miyamotoi-anaplasma-phagocytophilum-and-candidatus-neoehrlichia-mikurensis-in-ixodes-ricinus-ticks-collected-from-recreational-islands-in-southern-norway
#16
Vivian Kjelland, Katrine M Paulsen, Rikke Rollum, Andrew Jenkins, Snorre Stuen, Arnulf Soleng, Kristin S Edgar, Heidi H Lindstedt, Kirsti Vaino, Moustafa Gibory, Åshild K Andreassen
The aim of this study was to determine the occurrence of tick-borne pathogens of medical importance in questing ticks collected from five recreationally used islands along the Norwegian coastline. Furthermore, since coinfection may affect the disease severity, this study aimed to determine the extent of coinfection in individual ticks or co-localization of tick-borne pathogens. In all, 4158 questing Ixodes ricinus ticks were analyzed. For detection of tick-borne encephalitis virus (TBEV), nymphs (3690) were analyzed in pools of ten...
April 12, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29662016/persistent-borrelia-infection-in-patients-with-ongoing-symptoms-of-lyme-disease
#17
Marianne J Middelveen, Eva Sapi, Jennie Burke, Katherine R Filush, Agustin Franco, Melissa C Fesler, Raphael B Stricker
INTRODUCTION: Lyme disease is a tickborne illness that generates controversy among medical providers and researchers. One of the key topics of debate is the existence of persistent infection with the Lyme spirochete, Borrelia burgdorferi , in patients who have been treated with recommended doses of antibiotics yet remain symptomatic. Persistent spirochetal infection despite antibiotic therapy has recently been demonstrated in non-human primates. We present evidence of persistent Borrelia infection despite antibiotic therapy in patients with ongoing Lyme disease symptoms...
April 14, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29661882/-in-vitro-antimicrobial-susceptibility-of-clinical-isolates-of-borrelia-miyamotoi
#18
Joris Koetsveld, Annemijn Manger, Dieuwertje Hoornstra, Ronald O Draga, Anneke Oei, Nadezhda M Kolyasnikova, Marina G Toporkova, Denis S Sarksyan, Alex Wagemakers, Alexander E Platonov, Joppe W Hovius
Objectives : Borrelia miyamotoi is an emerging relapsing fever (RF) Borrelia species that is described to cause human disease in regions where Lyme borreliosis is endemic. We have recently shown that B. miyamotoi tick isolates are resistant to amoxicillin in vitro, however, clinical isolates have not been studied. Therefore, our aim was to show antimicrobial susceptibility of recently obtained clinical isolates of B. miyamotoi Methods : A dilution series of various antibiotics was made in MKP-F media. Susceptibility of different clinical B...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29660558/multilocus-sequence-analysis-of-borrelia-burgdorferi-sensu-lato-isolates-from-western-siberia-russia-and-northern-mongolia
#19
Yuliya Sabitova, Nataliya Fomenko, Artem Tikunov, Oleg Stronin, Maxim Khasnatinov, Davaajav Abmed, Galina Danchinova, Irina Golovljova, Nina Tikunova
Lyme borreliosis (LB) is the most frequently recorded tick-transmitted disease in Eurasia. Tomsk Province, Western Siberia in Russia and Selenge Aimag in Northern Mongolia are leading regions in the LB incidence rate in these countries. Spirochaetes of the Borrelia burgdorferi sensu lato (s.l.) complex isolated from Ixodes ticks from Tomsk Province (n = 56) and Ixodes persulcatus ticks from Selenge Aimag (n = 5) were genetically characterized using Multi Locus Sequence Typing (MLST), analysis of the 5S23S rRNA intergenic spacer (IGS) amplicons, and p83/100 gene sequencing...
April 13, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29657007/update-on-flea-and-tick-associated-diseases-of-cats
#20
Michael R Lappin
There are multiple vector-borne diseases in cats, the most prominent being those transmitted by mosquitos, sand flies, fleas, and ticks. Many of the agents vectored by fleas or ticks have been grown or amplified from blood or have induced antibodies in the serum of normal cats or those with clinical signs like fever and will be the focus of this manuscript. As high as 80% of fleas collected from cats contain at least one organism that could induce illness in cats or people. Anaplasma phagocytophilum, Bartonella spp...
April 30, 2018: Veterinary Parasitology
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