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Congenital nevus

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https://www.readbyqxmd.com/read/29776769/-congenital-kissing-nevus-lid-lesions
#1
Y Hanafi, N El Outassi, A El Omari, F El Asri, K Reda, A Oubaaz
No abstract text is available yet for this article.
May 15, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29736211/therapeutic-effects-of-targeting-ras-erk-signaling-in-giant-congenital-melanocytic-nevi
#2
Qingxiong Yu, Min Wu, Lingling Sheng, Qingfeng Li, Feng Xie
Most giant congenital melanocytic nevi (GCMN) exhibit an activating mutation in NRAS. Constitutive activation of the RAS-ERK signaling pathway induces proliferation in nevus cells and plays a pivotal role in melanoma development. In this study, we studied the efficacy of RAS-ERK pathway targeted therapy in GCMN. We isolated nevus cells from GCMN (GNCs) and compared the morphology of GNCs with normal melanocytes and the A375 melanoma cell line. Proliferation curves of GNCs and A375 cells were determined using Cell Counting Kit-8 assays...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29731591/extensive-nevus-comedonicus-complicated-with-recurrent-abscesses-successfully-treated-with-surgical-resurfacing
#3
Narender Manikavachakan, Maheshwari Nallur Siddaraju, Sarangapani Chakrapani Rajendran, Aniketh Venkataraman
Nevus comedonicus is a rare epidermal abnormality of the pilosebaceous unit, which is congenital in most patients but may also appear early in childhood. It may be localized or have an extensive involvement, the latter showing a unilateral predominance with only a few cases presenting bilaterally. Extensive nevus comedonicus can be associated with musculoskeletal defects, eye and neurological involvement, which constitutes nevus comedonicus syndrome. Uncomplicated nevus comedonicus can be treated with topical keratolytics, diode, erbium laser, and ultrapulse CO2 laser...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29653212/improving-classification-of-melanocytic-nevi-braf-v600e-expression-associated-with-distinct-histomorphologic-features
#4
Maija Kiuru, Danielle M Tartar, Lihong Qi, Danyang Chen, Lan Yu, Thomas Konia, John D McPherson, William J Murphy, Maxwell A Fung
BACKGROUND: A subset of melanomas carrying a BRAF V600E mutation, the most common targetable mutation in melanoma, arises in association with a melanocytic nevus also harboring a BRAF V600E mutation. The detailed histomorphologic characteristics of BRAF V600E-positive nevi are not systematically documented. OBJECTIVE: To identify histomorphologic features correlating with BRAF V600E status in nevi. METHODS: We retrospectively identified melanocytic nevi from our laboratory reporting system...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29625761/-recurrent-nevus-case-report-about-a-pagetoid-form-occurring-from-a-congenital-nevus-in-infancy
#5
L Bompy, J Levasseur, A Hallier, S Fraitag, M-H Aubriot-Lorton, B Bonniaud, N Zwetyenga
INTRODUCTION: Recurrent nevus (RN) is a cutaneous benign tumour with similarities with malignant lesions. Typically, it occurs after a partial resection of commun-acquired nevus. Its incidence varies from 0.3 to 27% according to the studies. We present here a pediatric case of a pagetoid form of a recurrent nevus occurring from a congenital nevus. CASE REPORT: A congenital nevus was removed from a 9-month-old girl. Pathologists concluded to a commun-acquired nevus of complete exeresis...
April 3, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29620005/congenital-nevus-lipomatosus-cutaneous-superficialis-of-hoffman-and-zurhelle-on-the-sole
#6
Hyun-Bin Kwak, Sang-Woo Park, Su-Kyung Park, Seok-Kweon Yun, Han-Uk Kim, Jin Park
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29619995/giant-congenital-melanocytic-nevus-associated-with-cerebellar-astrocytoma
#7
Xin Wang, Peng Luo, Harumi Hanazawa, Jia Liu, Long Li, Minghao Wang, Zhitao Jing
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29607755/common-and-not-so-common-melanocytic-lesions-in-children-and-adolescents
#8
Chen Yang, Alejandro A Gru, Louis P Dehner
The acquired melanocytic nevus is the most common lesion encountered by pediatric pathologists and dermatopathologists in their daily practice. In most cases, there are few difficulties in histopathologic diagnosis. However, it is the acquired melanocytic lesion known as the Spitz nevus, with its intrinsic atypical features which becomes the challenge since it exists along a histopathologic and biologic continuum from the atypical Spitz tumor to spitzoid melanoma. The frustration with some of these spitzoid lesions is that even the "experts" cannot agree as to the differentiation of one from the other even at the level of molecular genetics...
March 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29606826/atypical-proliferative-nodule-with-melanocytic-intraepidermal-pagetoid-spreading-arising-within-a-congenital-melanocytic-nevus-in-a-pregnant-woman
#9
Hye-Rim Moon, Mi Hye Lee, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Kee Chan Moon
No abstract text is available yet for this article.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29561439/functional-and-aesthetic-reconstruction-of-a-large-upper-lip-defect-using-combined-three-local-flaps-a-case-report
#10
Tian Meng, Hai-Lin Zhang, Xiao Long, Xiao-Jun Wang
RATIONALE: A significant clinical issue for treating patients with large upper lip defects is how to reconstruct the lip functionally and aesthetically. Traditional methods usually lead to asymmetry of the nasal base, philtrum and the lips. PATIENT CONCERNS: A 22-year-old lady presented with a large congenital nevus on her upper lip which involved the cutaneous, vermilion, and the philtrum. Secondary deformity caused by previous partial excisions was also identified...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29551421/blue-nevi-of-the-ocular-surface-clinical-characteristics-pathologic-features-and-clinical-course
#11
Ibrahim Sayed-Ahmed, Juan Carlos Murillo, Pedro Monsalve, Jan Paul Ulloa, Maria P Fernandez, James Wong, George Elgart, Anat Galor, Sander R Dubovy, Carol L Karp
PURPOSE: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS: Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016...
March 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29531606/one-step-melanoma-surgery-for-patient-with-thick-primary-melanomas-to-break-the-rules-you-must-first-master-them
#12
Georgi Tchernev
BACKGROUND: We present to the attention of the medical, dermatological and oncosurgical community data that serves to indicate the indispensability of optimisation of the algorithm and recommendations for diagnosis and surgical treatment of cutaneous melanoma. These recommendations could be referred to different subgroups of patients in different clinical stages as well as to patients with different initial characterisation (histological morphology) of the primary tumours. One step surgery is not a myth, even more, it could prove to be one of the best solutions for some patient collectives with advanced stages of melanoma...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29530698/neurocutaneous-melanosis-in-an-adult-patient-with-intracranial-primary-malignant-melanoma-case-report-and-review-of-the-literature
#13
Mian Ma, Zhi-Liang Ding, Zhi-Qi Cheng, Gang Wu, Xiao-Yu Tang, Peng Deng, Jian-Dong Wu
OBJECTIVE: To explore the clinical characteristics of neurocutaneous melanosis (NCM) in adult patients in order to help improve diagnosis and treatment of this disease. METHODS: We present a rare case of an adult patient suffering from neurocutaneous melanosis with malignant melanoma as well as a review Chinese and English literature, and analyze their clinical features. RESULTS: There were thirty adult NCM patients, aged 19 to 65 years old, average 27...
March 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29520504/fern-shaped-patch-as-a-hallmark-of-blue-rubber-bleb-nevus-syndrome-in-neonatal-venous-malformations
#14
Marta Ivars, Ana Martin-Santiago, Eulalia Baselga, Laurent Guibaud, Juan Carlos López-Gutiérrez
Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital vascular disease associated with important morbidity and non-insignificant risk of mortality in cases of severe gastrointestinal or neurological involvement. Early diagnosis in the neonatal period can be difficult as very often skin lesions appear progressively during childhood having no correlation with gastrointestinal lesion development. The appearance of one large venous malformation (VM) in the neonatal period has suggested a characteristic finding of this syndrome...
March 8, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29515391/giant-congenital-melanocytic-nevi-an-update-and-emerging-therapies
#15
Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura
Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Treatment of GCMN has conventionally been surgical. However, the role of NRAS inhibitors and inactivation of nevus tissue by high hydrostatic pressure are being explored. We present a case of a 1-day-old neonate born with GCMN, along with a review of the literature...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29492687/comparison-of-conventional-color-fundus-photography-and-multicolor-imaging-in-choroidal-or-retinal-lesions
#16
COMPARATIVE STUDY
Ilkay Kilic Muftuoglu, Raouf Gaber, Dirk-Uwe Bartsch, Amit Meshi, Michael Goldbaum, William R Freeman
PURPOSE: Our purpose was to compare the characteristics of the retinal and choroidal lesions including choroidal nevus, choroidal melanoma and congenital hypertrophy of the retina pigment epithelium using conventional color fundus photography (CFP) and multicolor imaging (MCI). METHODS: The paired images of patients with retinal or choroidal lesions were assessed for the visibility of lesion's border, halo and drusen using a grading scale (0-2). The area of the lesion was measured on both imaging modalities...
April 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29484013/medium-sized-congenital-melanocytic-nevus-with-suspected-progression-to-melanoma-during-pregnancy-what-s-the-best-for-the-patient
#17
Georgi Tchernev, Gabriela Atanasova Dzhelyatova, Uwe Wollina, Ilia Lozev, Torello Lotti
BACKGROUND: Congenital melanocytic nevi (CMN) are pigmented skin lesions usually present at birth. Rare varieties can develop and become clinically very large. Although they are benign nevomelanocytic neoplasms, all CMN may be precursors of the melanoma, regardless of their size. Individual risk of malignant transformation of melanocyte is determined by simultaneous action of exogenous and endogenous factors. The major exogenous risk factor is ultraviolet radiation. Leading roles among the endogenous factors are attributed to skin phenotype, gene mutation, sex hormones and their significance...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29482693/kissing-nevus-of-the-penis
#18
Shan Jiang, Yan Chen, Taylor E Hinchliffe, Tianfu Wu, Tyring Stephen
Kissing nevus is a very rare congenital melanocytic nevus. Here, we describe one case of kissing nevus on the penis. A 15-year boy presented with asymptomatic black to dark brown color patches on his penis. Histopathological findings showed that there were nests and cords of nevus cells in upper dermis. No significant cytologic atypia and mitoses were noted. Immunohistochemical stains revealed a partial positive for HMB-45 only in upper dermis and a stronger positivity for S-100 in almost all nevus cells. We diagnosed the lesion as kissing nevus of penis...
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29479946/new-therapies-for-vascular-anomalies-of-the-gi-tract
#19
Victor L Fox
Vascular anomalies are a morphologically and biologically diverse group of vascular channel abnormalities that are often congenital but may evolve or change over time in the developing child. Classification is based on a combination of physical and biological properties and clinical behavior that differentiate primarily between tumors and malformations and includes a few provisionally unclassified lesions. Anomalies of the GI tract may present clinically with GI bleeding, abdominal pain, high-output cardiac failure, and malabsorption...
February 23, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29453776/syndromic-sebaceous-nevus-current-findings
#20
Oumama El Ezzi, Anthony S de Buys Roessingh, Michèle Bigorre, Guillaume Captier
BACKGROUND: Sebaceous nevus is a congenital malformation of the skin that usually occurs on the scalp or face. Syndromic forms do rarely exist with associated cerebral and ocular malformations. The skin lesions are pale at birth and become irregular by puberty. In the adult patient, tumors (usually benign) develop from sebaceous nevus. Their surgical excision during childhood can give a better result in terms of the definitive scar. OBJECTIVES: The aim of this study is to analyze our cases of syndromic sebaceous hamartoma, perform a review of the existing literature, and propose guidelines for the therapeutic plan...
May 2018: International Journal of Dermatology
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