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Congenital nevus

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https://www.readbyqxmd.com/read/29147946/a-case-report-of-the-first-application-of-culture-epithelial-autograft-jace-%C3%A2-for-giant-congenital-melanocytic-nevus-after-its-approval-in-japan
#1
Naoki Morimoto, Natsuko Kakudo, Ayako Kako, Keiko Nishimura, Toshihito Mitsui, Ryohei Miyake, Atsuyuki Kuro, Masakatsu Hihara, Kenji Kusumoto
In Japan, the JACE(®) cultured epidermal autograft (CEA) was approved and covered by public healthcare insurance for use in the treatment of giant congenital melanocytic nevus (GCMN) in 2016. We herein report the results of the application of JACE(®) after curettage and Q-switched ruby laser therapy. The current patient was the first patient with GCMN to be treated with JACE(®) since its approval. A 3-month-old girl had a hairy GCMN of 9.5 cm in diameter from her cheek to her temple on the left side of her face...
November 17, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29138054/keratinocyte-sonic-hedgehog-up-regulation-drives-the-development-of-giant-congenital-nevi-via-paracrine-endothelin-1-secretion
#2
Arash Chitsazan, Blake Ferguson, Rehan Villani, Herlina Y Handoko, Pamela Mukhopadhyay, Brian Gabrielli, Wolter J Mooi, H Peter Soyer, Duncan Lambie, Kiarash Khosrotehrani, Grant Morahan, Graeme J Walker
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishment the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29131366/successful-and-safe-use-of-q-switched-lasers-in-the-treatment-of-nevus-of-ota-in-children-with-phototypes-iv-vi
#3
Daniel A Belkin, Hana Jeon, Elliot Weiss, Jeremy A Brauer, Roy G Geronemus
OBJECTIVE: Nevus of Ota represents congenital dermal melanocytosis in a trigeminal distribution, most commonly occurring in Asian individuals and other individuals with skin of color. Evidence suggests early treatment is beneficial. Multiple reports have shown efficacy and safety of Q-switched laser treatment in adults. There is little data on children and in non-Asian skin types. This series was done to demonstrate safe and effective use of Q-switched laser therapy in children of multiple skin types...
November 13, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29118701/nevus-comedonicus-case-report
#4
Renata Pinto Fernandes Timbó, Maria Kátia Gomes, Eduardo Mastrangelo Marinho Falcão, Marcia Ramos-E-Silva
Nevus comedonicus is a rare cutaneous anomaly, characterized by the clustering of papules with firm, blackened horny buffers. It in general has a zosteriform pattern and affects both genders equally. In some patients, there is formation of cysts, abscesses, and fistulas, aggravating its psychosocial impact. The association with extracutaneous lesions characterizes the nevus comedonicus syndrome. Despite several therapeutic options, the result is unsatisfactory in most cases. We report the case of a man with an exuberant congenital lesion, affecting the left suprascapular region, arm, and forearm...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29095741/eccrine-centric-melanocytic-nevus
#5
Raymond M Fertig, Adar Berghoff, Jessica Cervantes, Evan Darwin, Drazen Jukic
Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. The patient was a 50-year-old African American woman who noticed a new mole on her foot that began as a dark speck but quickly grew larger. The lesion was excised to exclude the possibility of melanoma...
October 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29091921/melanin-pigments-in-the-melanocytic-nevus-regress-spontaneously-after-inactivation-by-high-hydrostatic-pressure
#6
Michiharu Sakamoto, Naoki Morimoto, Chizuru Jinno, Atsushi Mahara, Shuichi Ogino, Shigehiko Suzuki, Kenji Kusumoto, Tetsuji Yamaoka
We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later...
2017: PloS One
https://www.readbyqxmd.com/read/29090468/clinicopathologic-characteristics-of-early-onset-becker-s-nevus-in-korean-children-and-adolescents
#7
Young J Kim, Mi R Roh, Ji H Lee, Jung I Na, Joo Y Ko, Joon M Jung, Jong H Lee, Sung E Chang
BACKGROUND: Becker's nevus (BN) presents as a hairy patch or plaque with or without proliferation of the dermal smooth muscles. BN has been described as acquired as found in a similar entity, congenital smooth muscle hamartoma (CSMH). This study was aimed at evaluating the clinicopathological aspects of BN in Korean cases in differential diagnosis with CSMH. METHODS: We performed a retrospective study of 103 patients histopathologically diagnosed as having BN or CSMH...
October 31, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29059098/proliferative-melanocytic-nodule-on-small-congenital-nevus-during-treatment-with-etanercept
#8
Martina Lambertini, Carlotta Baraldi, Annalisa Patrizi, Pier Alessandro Fanti, Barbara Corti, Cosimo Misciali, Marco Adriano Chessa, Emi Dika
No abstract text is available yet for this article.
October 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29053515/multiple-tissue-expansion-for-giant-congenital-melanocytic-nevus
#9
Yurema Gonzalez Ruiz, Juan Carlos López Gutiérrez
OBJECTIVE: Tissue expansion is the preferred technique for the treatment of giant congenital melanocytic nevus (GCMN) located on the face, abdomen, and legs. We believe that the use of multiple tissue expanders in the same surgery is a safe and effective technique for the treatment of GCMN. MATERIALS AND METHODS: A total of 14 patients were treated between 2013 and 2016 for GCMN removal with placement in the same surgery of 3 or more tissue expanders. We analyzed esthetic results and complications...
December 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29044700/epidermal-nevus-syndromes-new-insights-into-whorls-and-swirls
#10
REVIEW
Sarah Asch, Jeffrey L Sugarman
Knowledge of the molecular underpinnings of many epidermal nevi and epidermal nevus syndrome has expanded rapidly in recent years. In this review and update on epidermal nevus syndrome, we will cover recent genetic discoveries involving epidermal nevi, including nevus sebaceus, keratinocytic epidermal nevus, nevus comedonicus, congenital hemidysplasia with ichthyosiform nevus and limb defects syndrome, phakomatosis pigmentokeratotica, Becker's nevus, porokeratotic adnexal ostial nevus, inflammatory linear verrucous epidermal nevi, and cutaneous-skeletal hypophosphatemia syndrome...
October 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29036002/multimodal-imaging-in-klippel-tr%C3%A3-naunay-weber-syndrome-clinical-photography-computed-tomoangiography-infrared-thermography-and-99mtc-phytate-lymphoscintigraphy
#11
Su Wan Kim, Heesung Song
We report the case of a 19-year-old man who presented with a 12-year history of progressive fatigue, feeling hot, excessive sweating, and numbness in the left arm. He had undergone multimodal imaging and was diagnosed as having Klippel-Trénaunay-Weber syndrome (KTWS). This is a rare congenital disease, defined by combinations of nevus flammeus, venous and lymphatic malformation, and hypertrophy of the affected limbs. Lower extremities are affected mostly. Conventional modalities for evaluating KTWS are ultrasonography, CT, MRI, lymphoscintigraphy, and angiography...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29024276/large-plaque-type-blue-nevus-with-cellular-nodules-a-rare-unrecognized-melanocytic-tumor
#12
C Baraldi, B Corti, M Lambertini, P A Fanti, A Patrizi, E Dika
A 24-year-old Caucasian woman referred to us due to the modification of a congenital skin lesion in her right scapular area over the past 10 months. Physical examination disclosed multiple blue/whitish nodules arising on a bluish oval plaque, 6 cm in maximum diameter (fig. 1). The patient's personal and family medical history were unremarkable and negative for melanoma and non-melanoma skin cancers. The entire lesion was totally excised. Microscopy revealed a multifocal dermal proliferation of fusiform and dendritic melanocytes arranged in irregular nodules characterized by many individual foci with the histologic appearance of common blue nevus involving the reticular dermis (fig...
October 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28977136/the-fast-clinical-evolution-of-a-spitz-nevus-three-year-follow-up-of-a-child
#13
Maria Cristina Pedrazini, Victor Angelo Martins Montalli, Elemir Macedo de Souza
OBJECTIVE: To report the clinical evolution and handling of a Spitz nevus, from its initial flat feature to becoming an irregular, nodular, reddish lesion. CASE DESCRIPTION: Female child, phototype II, with a small congenital nevus on the left lower limb and other sustained small nevi. The patient went through annual clinical and dermoscopic evaluations between the ages of three and seven, period during which the nevi located on the left thigh grew rapidly. The clinical hypothesis was Spitz nevus, with indication of surgical removal with a safety margin and anatomopathological study...
September 21, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28966466/congenital-midline-nasal-anomalies
#14
Niraj Vora, Ram Kalagiri, Bryan Guillory, Ashita Shetty, Venkata Nakta Raju, R K Powitzky, Madhava R Beeram
Congenital midline nasal anomalies are rare, with a prevalence of 1 in 20,000 to 40,000 births and with 5% to 7% of them being nasal glioma. Differential diagnoses of nasal anomalies include nasal dermoid cysts, gliomas, encephaloceles, nasal polyps, and some other rare anomalies. Due to current medical technological advancements, most of these anomalies are easily correctable, though delaying management may lead to fatal effects. This report describes two cases-one of nasal glioma and one of nevus lipomatosus cutaneous superficialis-that presented as respiratory distress in a newborn...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28942405/congenital-melanocytic-nevus-mimicking-a-turban-tumour-in-an-18-year-old-filipino-male
#15
Maria Elinor Grace Sison, Eileen Cubillan, Bernard U Tansipek
Congenital melanocytic nevi (CMN) are nevi that are present at birth or arise within the first few weeks of life. They are often found on the trunk, head and neck and extremities. We report herein an unusual presentation of a CMN as a cerebriform tumour presenting as secondary cutis verticis gyrata on the scalp of an 18-year-old Filipino male.
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942302/congenital-cutaneous-panadnexal-papillomatous-hamartomas-in-a-calf
#16
I B Veiga, M Welle, J S Agerholm
Several cauliflower-like alopecic masses arose on the head of an otherwise healthy, full-term newborn Jersey × Belgian blue heifer, which was humanely destroyed shortly after birth due to the severity of the skin lesions. Microscopically, the masses were composed of multiple papillary projections displaying well-differentiated sebaceous glands surrounded by a moderate number of well-developed sweat glands, as well as embryonic and fully developed, but dysplastic hair follicles. Thick branching connective tissue stalks supported these adnexal components...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28913303/simultaneous-development-of-three-different-neoplasms-of-trichilemmoma-desmoplastic-trichilemmoma-and-basal-cell-carcinoma-arising-from-nevus-sebaceus
#17
Chi An Lee, Seok Joo Kang, Seong Pin Jeon, Hook Sun, Mi Seon Kang
Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. A 61-year-old male patient was admitted to our hospital for a 4 cm×2.5 cm growing tumor in a verrucous form arising within a periauricular nevus sebaceus in the post auricle of the left ear that had developed 30 years earlier...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28892945/pigmented-trichoblastoma-of-nose-an-unusual-occurrence
#18
D C Sathyaki, Mohammed Riyas, Mereen Susan Roy, R Jyothi Swarup, Nibha Raghu
Nevus sebaceus of Jadassohn is a congenital tumour affecting the scalp and face. It is usually presented as a pigmented patch or plaque. It is a complex cutaneous hamartoma which involves pilosebaceous follicle, epidermis and adnexal structures. Tumours that arise from nevus sebaceous are basal cell carcinoma, syringocystadenoma papilliferum, trichoblastoma and hidradenoma. The progression and frequency of the tumour increase with the age. Here we present a case of pigmented trichoblastoma over the external nose...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28880143/-an-infant-with-a-nevus-on-the-upper-leg
#19
M E Weijns, M Houtappel
We present a 4-month-old infant with an eczematous halo around a congenital melanocytic nevus. After diagnostic excision, histopathologic examination revealed a Meyerson's nevus. This is a benign skin tumour that may show clinical signs of melanoma. It is therefore important to include Meyerson's nevus in the differential diagnosis of melanoma.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28867912/deep-inferior-epigastric-perforator-free-flaps-for-use-in-complicated-groin-wound-repair-a-case-report-of-severe-groin-scar-contracture-and-review-of-pedicled-and-free-flaps-in-groin-wound-repair
#20
James D Kotick, Roger S Sandelin, Richard D Klein
The use of pedicled and free flaps for tissue transfer and coverage has become a common practice in modern plastic surgery. An area that presents considerable challenge for tissue coverage is the groin. Defects in this area are complicated by issues such as prior surgery; scar contracture; extension of the defect beyond the borders of the groin; radiation damage; high probability of infection; and involvement of vital underlying structures, the genitalia, and perineal and perianal area. Therefore, the choice of donor site and flap usage is often difficult...
August 2017: Journal of Hand and Microsurgery
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