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https://www.readbyqxmd.com/read/28717891/surgery-for-spinal-intramedullary-tumors-technique-outcome-and-factors-affecting-resectability
#1
Sherif Rashad, Amr Elwany, Ahmed Farhoud
Intramedullary spinal cord tumors (IMSCTs) are relatively infrequent lesions with ependymomas and astrocytomas representing the most common types. Microsurgical resection is established as the treatment of choice for these challenging lesions. We reviewed the surgical outcome of 29 cases operated for IMSCTs by the same surgeon between 2009 and 2015. The median follow-up period was 31 months, and all patients were followed up at least for 1 year. Among these 29 cases, 5 patients were previously operated for partial resection elsewhere...
July 17, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28714187/a-critique-of-utilitarian-and-instrumentalist-concepts-for-the-teaching-of-gross-anatomy-to-medical-and-dental-students-an-opinion-piece
#2
Bernard J Moxham, Diogo Pais
Medical and dental curricula, together with anatomical sciences courses, are increasingly having to change, mainly because there is a drive to being what is termed, without adequate definition, 'clinically relevant'. The concept of 'clinical anatomy' has accordingly been invented and it is expected that, at all times, the teaching of anatomy is directly focussed on clinical scenarios, meaning almost invariably the 'disease-based model of medicine and dentistry'. Furthermore, students are not expected to have a detailed knowledge of gross anatomy and the time devoted to teaching and learning the subject has decreased significantly...
July 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28713937/correlation-between-secreted-protein-acidic-and-rich-in-cysteine-protein-expression-and-the-prognosis-of-postoperative-patients-exhibiting-esophageal-squamous-cell-carcinoma
#3
Jian Wu, Jin-Rong Zhang, Xue-Qiu Jiang, Xu-Guang Cao
The aim of the present study was to investigate the association between the expression level of secreted protein acidic and rich in cysteine (SPARC) and the prognosis of postoperative patients with esophageal squamous cell carcinoma (ESCC). The expression level of SPARC was detected in the 89 ESCC tissue cases and 100 healthy esophageal mucosa cases, which served as the controls. Immunohistochemistry and reverse transcription‑polymerase chain reaction (RT‑PCR) were employed to evaluate the SPARC expression in cases with ESCC...
July 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713627/spinal-epidural-capillary-hemangioma-a-rare-case-report-with-a-review-of-literature
#4
M P Rajeev, Pravin Y Waykule, V M Pavitharan, B N Nandeesh
BACKGROUND: Purely epidural capillary hemangiomas are very rare. There are only 6 such reports. CASE DESCRIPTION: A 50-year-old male presented with a progressive lower extremity paraparesis. Magnetic resonance imaging demonstrated a purely epidural lesion at the L1-L2 level without any bony involvement. Following an L1-L2 laminectomy for total excision of the lesion, the patient showed significant improvement. The histopathology was consistent with a pure capillary hemangioma...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28713039/efficacy-of-ankle-foot-orthoses-types-on-walking-in-children-with-cerebral-palsy-a-systematic-review
#5
REVIEW
Atefeh Aboutorabi, Mokhtar Arazpour, Monireh Ahmadi Bani, Hassan Saeedi, John S Head
BACKGROUND: Ankle foot orthoses (AFOs) are orthotic devices that can be used to normalize the walking pattern of children with cerebral palsy (CP). One of the aims of orthotic management is to produce a more normal gait pattern by positioning joints in the proper position to reduce pathological reflex or spasticity. OBJECTIVE: To conduct a systematic review of the literature and establish the effect of treatment with various types of AFOs on gait patterns of children with CP...
July 13, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28708470/safety-and-efficacy-of-an-absorbable-filter-in-the-inferior-vena-cava-to-prevent-pulmonary-embolism-in-swine
#6
Steven Y Huang, Mitchell Eggers, Mark J McArthur, Katherine A Dixon, Amanda McWatters, Stephen Dria, Lori R Hill, Marites P Melancon, Joseph R Steele, Michael J Wallace
Purpose To evaluate the immediate and long-term safety as well as thrombus-capturing efficacy for 5 weeks after implantation of an absorbable inferior vena cava (IVC) filter in a swine model. Materials and Methods This study was approved by the institutional animal care and use committee. Eleven absorbable IVC filters made from polydioxanone suture were deployed via a catheter in the IVC of 11 swine. Filters remained in situ for 2 weeks (n = 2), 5 weeks (n = 2), 12 weeks (n = 2), 24 weeks (n = 2), and 32 weeks (n = 3)...
July 14, 2017: Radiology
https://www.readbyqxmd.com/read/28705420/is-it-necessary-to-perform-full-pathologic-review-of-all-gastric-remnants-following-sleeve-gastrectomy
#7
S K Hansen, B J Pottorf, H W Hollis, J L Rogers, F A Husain
BACKGROUND: This study attempts to determine if enough pathological abnormalities in gastric remnants from sleeve gastrectomy exist to warrant full pathologic evaluation in all remnants. METHODS: Data was collected on patients undergoing sleeve gastrectomy between 08/01/2011 and 06/30/2014. Significant abnormalities were classified as any pathology that might require follow-up or treatment beyond standard follow-up. Age, comorbidities, gender, and Helicobacter pylori titers were analyzed and compared with pathology specimens using 95% confidence intervals and Phi contingency coefficients...
July 1, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28701767/actomyosin-and-vimentin-cytoskeletal-networks-regulate-nuclear-shape-mechanics-and-chromatin-organization
#8
Michael C Keeling, Luis R Flores, Asad H Dodhy, Elizabeth R Murray, Núria Gavara
The regulation of nuclear state by the cytoskeleton is an important part of cellular function. Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary roles in integrating the nucleus into its environment and influencing its mechanical state. However, the interconnectedness of cytoskeletal networks makes it difficult to dissect their individual effects on the nucleus. We use simple image analysis approaches to characterize nuclear state, estimating nuclear volume, Poisson's ratio, apparent elastic modulus and chromatin condensation...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699066/effect-comparisons-among-treatment-measures-on-progression-free-survival-in-patients-with-skull-base-chordomas-a-retrospective-study-of-234-post-surgical-cases
#9
Liang Wang, Kaibing Tian, Junpeng Ma, Ke Wang, Guijun Jia, Zhen Wu, Liwei Zhang, Junting Zhang
BACKGROUND: Skull base chordoma (SBC) is a rare and refractory tumor with a high rate of relapse. We aimed to investigate the relationships between different treatment measures and progression-free survival (PFS) outcomes. METHODS: Data from 234 SBC patients from one institution were retrieved from a prospectively maintained database. After grouping, the clinicopathological features and mean estimated PFS times were subject to inter-group and intra-group comparisons, and prognostic factors of PFS were estimated by statistical analyses...
July 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28695811/clinicopathological-features-analysis-of-86-endometrial-endometrioid-adenocarcinoma-patients-with-adnexal-involvement
#10
Jing Zuo, Min Cheng, Yan Song, Zhuo Li, Rong Zhang, Bin Li, Lingying Wu
To investigate the clinicopathological features of endometrial endometrioid adenocarcinoma(EEA)with adnexal involvement.Methods The clinicopathological data of 86 EEA patients who underwent surgical treatment at our center from January 2000 to December 2015 were analyzed retrospectively.The clinicopathological features were compared between patients with occult adnexal involvement and those with gross adnexal involvement.Results A total of 86 EEA patients with adnexal involvement(mean age:58.1 years)were included in this study,accounting for 5...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28689343/a-rare-case-report-and-literatures-review-on-primary-germinoma-in-cerebellar-hemisphere
#11
Lei Wang, Wanchun Zhu, Xiang Li, Jintao He, Chunde Li, Jian Gong
OBJECT: Primary intracranial germinoma is a rare intracranial lesion which accounts for approximately 0.5-2% of all intracranial tumors. Generally, primary intracranial germinoma occurs in the midline structures of the central nervous system of a pediatric patient. Only four cases of primary cerebellar germinomas with poor prognosis have been previously reported. The object of this paper is to introduce a case of germinoma originating from cerebellar hemisphere and to discuss its clinical features...
July 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28689230/the-extended-transnasal-transsphenoidal-approach-for-anterior-skull-base-meningioma-considerations-in-patient-selection
#12
Joseph P Castlen, David J Cote, Hasan A Zaidi, Edward R Laws
PURPOSE: In this study, we set out to define our institutional criteria for patient eligibility for transsphenoidal resection of parasellar meningiomas, and to report our experience with extended transnasal approaches for these lesions. We aimed to discuss the important considerations of patient selection and risk stratification to optimize outcomes for patients with these difficult lesions, and also include considerations that should be reviewed during surgical approach selection. METHODS: Medical records from Brigham and Women's Hospital were retrospectively reviewed for all patients who underwent transsphenoidal surgery for pituitary disease with the senior author from April 2008 to March 2017 (938 procedures)...
July 8, 2017: Pituitary
https://www.readbyqxmd.com/read/28688892/vascular-ossification-pathology-mechanisms-and-clinical-implications
#13
Michael A Fuery, Lusha Liang, Frederick S Kaplan, Emile R Mohler
In recent years, the mechanisms and clinical significance of vascular calcification have been increasingly investigated. For over a century, however, pathologists have recognized that vascular calcification is a form of heterotopic ossification. In this review, we aim to describe the pathology and molecular processes of vascular ossification, to characterize its clinical significance and treatment options, and to elucidate areas that require further investigation. The molecular mechanisms of vascular ossification involve the activation of regulators including bone morphogenic proteins and chondrogenic transcription factors and the loss of mineralization inhibitors like fetuin-A and pyrophosphate...
July 5, 2017: Bone
https://www.readbyqxmd.com/read/28687446/preservation-of-hormonal-function-by-identifying-pituitary-gland-at-endoscopic-surgery
#14
Stefan Linsler, Renate Hero-Gross, Bettina Friesenhahn-Ochs, Salman Sharif, Frank Lammert, Joachim Oertel
OBJECTIVE: The endonasal endoscopic approach has been established for perisellar tumor surgery with a higher resection rate and reduced complications. We analyzed the potential to identify the pituitary gland under endoscopic view, at surgery and see its relation to postoperative hormonal insufficiency in endonasal endoscopic procedures. METHODS: Between January 2011 and January 2014, 70 cases of pituitary adenomas with preoperative intact pituitary function underwent endoscopic endonasal transsphenoidal procedures for intrasellar pathologies...
July 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28686121/surgical-and-molecular-considerations-in-the-treatment-of-pediatric-thalamopeduncular-tumors
#15
Ryan P Lee, Kimberly A Foster, Jock C Lillard, Paul Klimo, David W Ellison, Brent Orr, Frederick A Boop
OBJECTIVE Thalamopeduncular tumors are a group of pediatric low-grade gliomas that arise at the interface of the thalamus and brainstem peduncle. They typically occur within the first 2 decades of life, presenting with progressive spastic hemiparesis. Treatment strategies, including surgical intervention, have varied significantly. The authors present their experience in the treatment of 13 children, ages 2-15 years, with non-neurofibromatosis-related pilocytic astrocytomas located in the thalamopeduncular region...
July 7, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28683235/prognostic-variables-affecting-primary-treatment-outcome-for-medullary-thyroid-cancer
#16
Suhael Momin, Deborah Chute, Brian Burkey, Joseph Scharpf
OBJECTIVE: Identifying prognostic risk factors and determining the efficacy of common surgical treatments is critical to determine optimal treatment strategies for patients with medullary thyroid carcinoma (MTC). The objective of this study was to review a contemporary institutional experience with medullary thyroid carcinoma primary treatment with two goals: to identify prognostic factors that affect survival and to study the effect of neck dissection on those outcomes. METHODS: This study is a retrospective case series of patients with MTC who underwent at least a total thyroidectomy with curative intent...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28678885/assessment-of-bcg-and-inactivated-mycobacterium-bovis-vaccines-in-an-experimental-tuberculosis-infection-model-in-sheep
#17
Ana Balseiro, Raúl Altuzarra, Enric Vidal, Xavier Moll, Yvonne Espada, Iker A Sevilla, Mariano Domingo, Joseba M Garrido, Ramón A Juste, Miguel Prieto, Bernat Pérez de Val
BACKGROUND/AIMS: Animal tuberculosis (TB) is a complex animal health problem that causes disruption to trade and significant economic losses. TB involves a multi-host system where sheep, traditionally considered a rare host of this infection, have been recently included. The aims of this study were to develop an experimental TB infection model in sheep with a Mycobacterium caprae field strain isolated from a tuberculous diseased ewe, and to use this to evaluate the safety and efficacy of two vaccines against TB in sheep, the live-attenuated M...
2017: PloS One
https://www.readbyqxmd.com/read/28674451/novel-interventional-management-of-hepatic-hydatid-cyst-with-nanosecond-pulses-on-experimental-mouse-model
#18
Xinhua Chen, Ruiqing Zhang, Tuerganaili Aji, Yingmei Shao, Yonggang Chen, Hao Wen
The nanosecond pulsed electric field (nsPEF) is investigated as an alternative plan for benign hepatic hydatid cyst. Altogether 72 C57B6 mice were included. Normal group (n = 12) had no parasite injection and the other 60 mice were used to induce hydatid cyst in liver by injecting protoscolices in portal vein. The liver hydatid cysts were exposed to nsPEF with different doses and then follow up. The standard surgery was performed as positive control. The hydatid cyst growth was monitored by ultrasound; the morphology was checked by gross anatomy and pathology was tested by H&E stain...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28673887/clinical-radiological-and-pathological-features-of-56-cases-of-intracranial-lymphoplasmacyte-rich-meningioma
#19
Xiaogang Tao, Kun Wang, Jinqian Dong, Zonggang Hou, Zhen Wu, Junting Zhang, Baiyun Liu
OBJECTIVE: Intracranial lymphoplasmacyte-rich meningioma (LPRM) is rarely reported because of its extremely low incidence, and current understanding of this disease is poor. We analyzed the incidence and clinical, radiological, pathological, and prognostic features of intracranial LPRMs. METHODS: Approximately 10,908 intracranial meningiomas were surgically resected in Beijing Tiantan Hospital between June 2009 and November 2016. All pathologically proven LPRM cases were identified...
June 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28673006/comparison-of-the-gas-liquid-dual-support-fixation-and-heitzman-fixation-techniques-for-preparing-lung-specimens
#20
Dongsheng Yu, Weili Qu, Haipeng Xia, Xiaofeng Li, Zhenfeng Luan, Renjie Yan, Xiaodong Lu, Peng Zhao
The aim of the present study was to compare the gas-liquid dual support fixation and Heitzman fixation techniques for the preparation of lung specimens. A total of 40 fresh lung samples were surgically collected from 40 male patients with lung cancer by biopsy. Patients were recruited from the Affiliated Hospital of Qingdao University Medical College (Qingdao, China) between July 2007 and June 2014. Samples were prepared using either the gas-liquid dual support fixation method (group A; n=26) or the Heitzman fixation method (group B; n=14)...
July 2017: Experimental and Therapeutic Medicine
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