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https://www.readbyqxmd.com/read/28229903/acute-and-subchronic-toxicity-studies-of-methanol-extract-of-polygonum-minus-leaves-in-sprague-dawley-rats
#1
Parayil Varghese Christapher, Subramani Parasuraman, Mohd Zaini Asmawi, Vikneswaran Murugaiyah
Medicinal plant preparations may contain high levels of toxic chemical constituents to potentially cause serious harm to animals and/or humans. Thus, toxicity studies are important to assess the toxic effects of plant derived products. Polygonum minus is used traditionally for different ailments in Southeast Asia. This study was conducted to establish the acute and subchronic toxicity profile of the methanol extract of P. minus leaves. The acute toxicity study showed that the methanol extract of P. minus is safe even at the highest dose tested of 2000 mg/kg in female Sprague Dawley rats...
February 13, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28228300/lutembacher-s-syndrome-is-the-mitral-pathology-always-rheumatic
#2
Pradeep Vaideeswar, Supreet Marathe
The mitral valve disease (MVD) in Lutembacher's syndrome has been infrequently analyzed from a pathological standpoint. In this study, we have attempted to elucidate the pathology of MVD in this interesting syndrome in 44 autopsied cases of combined non-primum atrial septal defect (ASD) and MVD collected over 16 years. The patients were divided into 3 groups: Group 1: non-primum ASD with clinically diagnosed mitral stenosis (MS)±regurgitation, Group 2: non-primum ASD with clinically diagnosed mitral regurgitation (MR) and, Group 3: non-primum ASD with no clinically evident MVD, but with mitral valve pathology diagnosed at autopsy...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28226354/-prognostic-factors-of-lymph-node-negative-metastasis-gastric-cancer
#3
Ding Sun, Huimian Xu, Jinyu Huang
OBJECTIVE: To investigate the prognostic factors of patients with lymph node-negative metastasis gastric cancer (pN0). METHODS: Clinicopathological data of patients with pN0 gastric cancer who underwent radical operation at the Department of Surgical Oncology, The First Hospital of China Medical University from May 1980 to August 2012 were collected and analyzed retrospectively. INCLUSION CRITERIA: (1) Patients were diagnosed as gastric adenocarcinoma; (2) Postoperative pathology confirmed T1a to 4bN0M0 gastric cancer; (3) Total number of harvested lymph node was more than 15...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28224975/intraperitoneal-infusion-of-neutral-ph-superoxidized-solution-in-rats-evaluation-of-toxicity-and-complications-on-peritoneal-surface-and-liver
#4
Abbas Aras, Erbil Karaman, Serkan Yıldırım, Özkan Yılmaz, Remzi Kızıltan, Kamuran Karaman
BACKGROUND Superoxidized water (SOW) is known to be a potent disinfectant. The aim of this study was to evaluate the toxicity and complications on the peritoneal surface and liver after infusion of pH-neutral SOW into the peritoneal cavity of rats. MATERIAL AND METHODS Thirty Wistar-Albino rats weighing 250-300 g were randomly divided into 3 groups (10 rats/group). Group1 (control group) rats received single dose of 10 mg/kg saline solution intraperitoneally. Group 2 (single-dose group) rats received a single dose of 10 mg/kg pH-neutral SOW intraperitoneally...
February 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28224334/the-trpm4-channel-is-functionally-important-for-the-beneficial-cardiac-remodeling-induced-by-endurance-training
#5
Mélanie Gueffier, Justin Zintz, Karen Lambert, Amanda Finan, Franck Aimond, Nourdine Chakouri, Christophe Hédon, Mathieu Granier, Pierre Launay, Jérôme Thireau, Sylvain Richard, Marie Demion
Cardiac hypertrophy (CH) is an adaptive process that exists in two distinct forms and allows the heart to adequately respond to an organism's needs. The first form of CH is physiological, adaptive and reversible. The second is pathological, irreversible and associated with fibrosis and cardiomyocyte death. CH involves multiple molecular mechanisms that are still not completely defined but it is now accepted that physiological CH is associated more with the PI3-K/Akt pathway while the main signaling cascade activated in pathological CH involves the Calcineurin-NFAT pathway...
February 21, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28224086/early-robotic-repair-of-vesicouterine-fistula-a-case-report-and-literature-review
#6
Othman J Alamoudi, Mohammed A AlTheneyan, Naif Aldhaam, Maher Moazin
As cesarean sections become a more common mode of delivery, they have become the most likely cause of vesicouterine fistula formation. The associated pathology with repeat cesarean deliveries may make repair of these fistulas difficult. Early robotic-surgery offers a 3-dimensional view of the operative field and allows for intricate movements necessary for complex suturing and dissection. These qualities are advantageous in vesicouterine fistula repair. 42 years old female day 12 post-LSCS in author hospital with history of bladder injury and folly's catheter in place since OR complain of gross hematuria for 8 days...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28221082/partial-lesion-of-the-nigrostriatal-dopamine-pathway-in-rats-impairs-egocentric-learning-but-not-spatial-learning-or-behavioral-flexibility
#7
Katharine M Seip-Cammack, James J Young, Megan E Young, Matthew L Shapiro
Degeneration of the nigrostriatal dopaminergic system in Parkinson's disease (PD) causes motor dysfunction and cognitive impairment, but the etiology of the cognitive deficits remains unclear. The present study investigated the behavioral effects of partial lesions of the nigrostriatal dopamine (DA) pathway. Rats received bilateral infusions of either 6-hydroxydopamine (6-OHDA) or vehicle into the dorsolateral striatum and were tested in spatial and procedural learning tasks. Compared with intact rats, DA-depleted rats were impaired when the first task they learned required egocentric responses...
February 20, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28217933/cytology-of-the-neovagina-in-transgender-women-and-individuals-with-congenital-or-acquired-absence-of-a-natural-vagina
#8
A Grosse, C Grosse, D Lenggenhager, B Bode, U Camenisch, P Bode
OBJECTIVE: The primary objective of this study was to describe the cytological findings of bowel and (penile) skin-lined neovaginas in patients with gender dysphoria (GD) and individuals with a congenital or acquired absence of a natural vagina. The secondary objective was to correlate the cytological findings with clinical characteristics such as oestrogen replacement therapy (ERT). METHODS: A retrospective review of an institutional pathology archive over a 15-year-period was performed to identify cytological samples of neovaginal vaults...
February 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28210641/atypical-plasmacytic-proliferation-in-a-case-of-c3-glomerulopathy-pathophysiology-demystified
#9
Osama Elfituri, Nathan Aardsma, Suman Setty, Frederick Behm, Kimberly Czech
An 11-year-old Hispanic female underwent evaluation of asymptomatic proteinuria and hematuria. The patient denied fever, edema, and gross hematuria. Urinalysis showed mild proteinuria, and a urine microscopic examination revealed red blood cells. Screening tests for glomerulonephritis revealed a low C3 and negative ANA, ASO, DNAse-B, and ANCA. Histological examination of a renal biopsy specimen showed glomeruli with endocapillary proliferation, a predominant C3 deposition in the capillary loops by immunofluorescence, and electron dense deposits in the mesangium, paramesangium, and capillary walls by electron microscopy consistent with a diagnosis of C3 glomerulopathy...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28209476/the-role-of-a-psp-producing-alexandrium-bloom-in-an-unprecedented-diamondback-terrapin-malaclemys-terrapin-mortality-event-in-flanders-bay-new-york-usa
#10
Theresa K Hattenrath-Lehmann, Robert J Ossiboff, Craig A Burnell, Carlton D Rauschenberg, Kevin Hynes, Russell L Burke, Elizabeth M Bunting, Kim Durham, Christopher J Gobler
Diamondback terrapins (Malaclemys terrapin) are a threatened or endangered species in much of their range along the U.S. Atlantic and Gulf coasts. Over an approximately three-week period from late April to mid-May 2015, hundreds of adult diamondback terrapins were found dead on the shores of Flanders Bay, Long Island, New York, USA. Concurrent with the mortality event, elevated densities of the paralytic shellfish toxin (PST)-producing dinoflagellate, Alexandrium fundyense (>10(4) cells L(-1)) and high levels of PST in bivalves (maximal levels = 540 μg STX eq...
February 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28199858/associations-between-hippocampal-morphology-diffusion-characteristics-and-salivary-cortisol-in-older-men
#11
Simon R Cox, Maria Del Carmen Valdés Hernández, Jaeil Kim, Natalie A Royle, Sarah E MacPherson, Karen J Ferguson, Susana Muñoz Maniega, Devasuda Anblagan, Benjamin S Aribisala, Mark E Bastin, Jinah Park, John M Starr, Ian J Deary, Alasdair M J MacLullich, Joanna M Wardlaw
High, unabated glucocorticoid (GC) levels are thought to selectively damage certain tissue types. The hippocampus is thought to be particularly susceptible to such effects, and though findings from animal models and human patients provide some support for this hypothesis, evidence for associations between elevated GCs and lower hippocampal volumes in older age (when GC levels are at greater risk of dysregulation) is inconclusive. To address the possibility that the effects of GCs in non-pathological ageing may be too subtle for gross volumetry to reliably detect, we analyse associations between salivary cortisol (diurnal and reactive measures), hippocampal morphology and diffusion characteristics in 88 males, aged ∼73 years...
January 27, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28197623/-primary-malignant-melanoma-in-the-brain-of-a-7-month-old-sheep-ovis-aries-f-domestica
#12
Wolfram Breuer, Angela Hafner-Marx
A case of malignant melanoma in a sheep's brain is described for the first time. In a 7-month-old sheep that had been euthanized due to ataxia, post-mortem and histopathologic examinations were performed. Both the brain and the calvarium were heavily infiltrated with neoplastic tissue. Metastases were found in the liver and kidneys. Histomorphology confirmed the gross pathologic impression of malignancy. Congenital melanosis, which is regularly present in the meninx of sheep, could have been the origin of the malignant melanoma in the present case...
February 15, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28195621/histopathologic-analysis-of-the-posterior-segment-for-terson-s-syndrome-the-giobiopsy-technique
#13
Jerome V Giovinazzo, Vincent J Giovinazzo, Codrin Iacob, Richard B Rosen, Paul T Finger
The purpose of this study was to report on a case of Terson's syndrome (TS) using a novel instrument and technique to harvest posterior pole pathology from a postmortem eye. A modified ocular clamp was used to remove the posterior pole from the postmortem enucleated eye. Gross photographs were taken and an ocular sample of the posterior pole was sent to The New York Eye and Ear Pathology Laboratory. TS was identified from gross pathology and histologic examinations. The case history was consistent with that diagnosis...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28194401/clinical-application-of-cone-beam-computed-tomography-of-the-rabbit-head-part-2-dental-disease
#14
G G Riggs, Derek D Cissell, Boaz Arzi, David C Hatcher, Philip H Kass, Amy Zhen, Frank J M Verstraete
Domestic rabbits are increasing in popularity as household pets; therefore, veterinarians need to be familiar with the most common diseases afflicting rabbits including dental disease. Current diagnostic approaches include gross oral examination, endoscopic oral examination, skull radiography, and computed tomography (CT). Cone beam computed tomography (CBCT), a new oral and maxillofacial imaging modality that has the capability to produce high-resolution images, has not yet been described for use in evaluating dental disease in rabbits...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28193010/variations-in-the-abundance-of-lipid-biomarker-ions-in-mass-spectrometry-images-correlate-to-tissue-density
#15
Jade Bilkey, Alessandra Tata, Trevor D McKee, Andreia M Porcari, Emma Bluemke, Michael Woolman, Manuela Ventura, Marcos N Eberlin, Arash Zarrine-Afsar
While mass spectrometry (MS) imaging is widely used to investigate the molecular composition of ex vivo slices of cancerous tumors, little is known about how variations in the cellular properties of cancer tissue can influence cancer biomarker ion images. To better understand the basis for variations in the abundances of cancer biomarker ions seen in MS images of relatively homogeneous ex vivo tumor samples, sections of snap frozen human breast cancer murine xenografts were subjected to desorption electrospray ionization mass spectrometry (DESI-MS) imaging...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28188914/connectivity-based-parcellation-reveals-distinct-cortico-striatal-connectivity-fingerprints-in-autism-spectrum-disorder
#16
Joshua H Balsters, Dante Mantini, Nicole Wenderoth
Autism Spectrum Disorder (ASD) has been associated with abnormal synaptic development causing a breakdown in functional connectivity. However, when measured at the macro scale using resting state fMRI, these alterations are subtle and often difficult to detect due to the large heterogeneity of the pathology. Recently, we outlined a novel approach for generating robust biomarkers of resting state functional magnetic resonance imaging (RS-fMRI) using connectivity based parcellation of gross morphological structures to improve single-subject reproducibility and generate more robust connectivity fingerprints...
February 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28185980/a-new-quantitative-measure-of-disc-degeneration
#17
Tapio Videman, Michele C Battié, Laura E Gibbons, Kevin Gill
BACKGROUND CONTEXT: The ability to adequately measure a phenomenon is critical to studying and understanding it. Since 1957, a variety of subjective visual grading methods have been used to assess disc degeneration, but have been limited by gross ordinal scales and imprecision, as well as suboptimal reliability. Conceptually sound, objective, precise measurements are needed to advance knowledge of disc degeneration and its causes, progression and consequences. PURPOSE: To investigate the reliability and validity of a new system ('SpIn' for Spine Insight) to quantitatively measure lumbar disc degeneration or pathology...
February 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28181678/safety-and-immunological-efficacy-of-a-dna-vaccine-encoding-the-androgen-receptor-ligand-binding-domain-ar-lbd
#18
Brian M Olson, Eric S Bradley, Thomas Sawicki, Weixiong Zhong, Erik A Ranheim, Jordan E Bloom, Viswa T Colluru, Laura E Johnson, Brian T Rekoske, Jens C Eickhoff, Douglas G McNeel
BACKGROUND: The androgen receptor (AR) is a key oncogenic driver of prostate cancer, and has been the primary focus of prostate cancer treatment for several decades. We have previously demonstrated that the AR is also an immunological target antigen, recognized in patients with prostate cancer, and targetable by means of vaccines in rodent models with delays in prostate tumor growth. The current study was performed to determine the safety and immunological efficacy of a GMP-grade plasmid DNA vaccine encoding the ligand-binding domain (LBD) of the AR, pTVG-AR...
February 9, 2017: Prostate
https://www.readbyqxmd.com/read/28180074/regional-staging-of-white-matter-signal-abnormalities-in-aging-and-alzheimer-s-disease
#19
Emily R Lindemer, Douglas N Greve, Bruce R Fischl, Jean C Augustinack, David H Salat
White matter lesions, quantified as 'white matter signal abnormalities' (WMSA) on neuroimaging, are common incidental findings on brain images of older adults. This tissue damage is linked to cerebrovascular dysfunction and is associated with cognitive decline. The regional distribution of WMSA throughout the cerebral white matter has been described at a gross scale; however, to date no prior study has described regional patterns relative to cortical gyral landmarks which may be important for understanding functional impact...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180010/extreme-thrombocytosis-presenting-in-anti-neutrophil-cytoplasmic-autoantibodies-associated-crescentic-glomerulonephritis-with-immune-complex-deposits-a-case-report
#20
Zhang Xuemei, Diao Yongshu, Zhang Ling, Yang Yingying, Fu Ping
INTRODUCTION: We describe a female patient with extreme reactive thrombocytosis (RT) in anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated crescentic glomerulonephritis (CGN) with immune complex deposits, which has never been reported before. CASE PRESENTATION: A female adolescent with symptoms of oliguria and gross hematuresis had serious renal function impairment (crescent formation and immune complex deposits in renal pathology examination with positive serum ANCA) and extreme thrombocytosis...
October 2016: Iranian Red Crescent Medical Journal
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