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https://www.readbyqxmd.com/read/29787514/therapeutic-effects-of-human-adipose-derived-products-on-impaired-wound-healing-in-irradiated-tissue
#1
Szu-Hsien Wu, Takako Shirado, Takanobu Mashiko, Jingwei Feng, Rintaro Asahi, Koji Kanayama, Masanori Mori, Daekwan Chi, Ataru Sunaga, Shunji Sarukawa, Kotaro Yoshimura
BACKGROUND: Clinical sequelae of irradiation (ischemia, fibrosis, and atrophy) result in tissue devitalization, where wound healing capacity is impaired. Fat or fat-derived products may work to treat such pathology. METHODS: Non-lethal irradiation at various doses (5 Gy, 10 Gy, 15 Gy) and frequencies (1-3 times on sequential days) was delivered to dorsal skin of 7-week-old nude mice, evaluating subsequent gross and microscopic changes for up to 4 weeks. Cutaneous punch wounds were then created, to compare wound healing in irradiated and non-irradiated states...
May 16, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29784593/diagnosis-and-surgical-management-of-inferior-vena-cava-leiomyomatosis
#2
Chao Yang, Huimin Fang, Yunsong Yang, Fei Cai, Hong Zheng, Bi Jin, Yiqing Li, Zheng Liu, Mohamed A Zayed
OBJECTIVE: We aimed to review our experience in the diagnosis and surgical management of patients diagnosed with inferior vena cava leiomyomatosis (IVL). METHODS: We retrospectively evaluated all patients diagnosed with IVL between 1999 and 2015. Patient demographics, diagnostic imaging, operative techniques, and perioperative outcomes were reviewed. RESULTS: Over the study period, 16 patients with an IVL diagnosis were identified. In all patients, the diagnosis was made with ultrasound and magnetic resonance imaging...
May 18, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29780625/is-a-5-mm-diameter-an-appropriate-cut-off-value-for-the-diagnosis-of-atypical-adenomatous-hyperplasia-and-adenocarcinoma-in-situ-on-chest-computed-tomography-and-pathological-examination
#3
Xiaohuan Pan, Xinguan Yang, Jingxu Li, Xiao Dong, Jianxing He, Yubao Guan
Background: Preinvasive lesions, such as atypical adenomatous hyperplasia (AAH) and adenocarcinoma in situ (AIS), usually appear as pure ground-glass nodules (pGGNs) on thin-section computed tomography (TSCT). AAH is usually less than 5 mm wide on imaging and pathological examinations. We aimed to determine whether a 5-mm cut-off value was appropriate for the diagnosis of AAH and AIS. Methods: We retrospectively analyzed the performance of TSCT in evaluating 80 pathologically confirmed preinvasive lesions (33 AAH lesions in 31 patients and 47 AIS lesions in 45 patients)...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780071/symptomatic-remote-cyst-after-bcnu-wafer-implantation-for-malignant-glioma
#4
Hideaki Matsumura, Eiichi Ishikawa, Masahide Matsuda, Noriaki Sakamoto, Hiroyoshi Akutsu, Shingo Takano, Akira Matsumura
A 43-year-old man was operated on for right frontal oligoastrocytoma. 14 years after the surgery, magnetic resonance imaging and positron emission tomography revealed a new lesion near the surgical cavity. He underwent gross total resection of the lesion and implantation of bis-chloroethylnitrosourea (BCNU) wafers after intraoperative pathological diagnosis of recurrent high-grade glioma. A few days after the operation, the level of consciousness gradually worsened and left hemiparesis developed. A computed tomography scan revealed a cyst remote to the surgical cavity which did not exist 3 days prior...
May 21, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29779939/endometrial-carcinoma-in-a-single-horn-of-a-bicornuate-uterus-a-case-report
#5
Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni Scambia
We discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy. The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn showed a neoplastic growth of 10 cm with infiltration of about 1,8 cm of the myometrium from whole thickness of 1...
May 17, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29778208/enhanced-infection-of-avian-influenza-virus-h9n2-with-infectious-laryngeotracheitis-vaccination-in-chickens
#6
Nagah Arafat, Abdelfattah H Eladl, Basma H Marghani, Mohamed A Saif, Reham A El-Shafei
Avian influenza and infectious laryngeotracheitis viruses are common causes of respiratory diseases in chickens with economical importance worldwide. In this study, we investigated the effect of experimental co-infection of avian influenza virus-H9N2 (AIV-H9N2) with infectious laryngeotracheitis virus (ILTV) live-attenuated vaccine (LAR-VAC® ) on chickens. Four experimental groups were included in this study: negative control group, AIV-H9N2 group, AIV-H9N2+LAR-VAC® group, and LAR-VAC® group. AIV-H9N2 was inoculated intranasally to challenged groups at 35 days of age...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29777888/primary-intracranial-rhabdomyosarcoma-in-the-cerebellopontine-angle-resected-after-preoperative-embolization
#7
Keisuke Yoshida, Tomoru Miwa, Takenori Akiyama, Masaaki Nishimoto, Dai Kamamoto, Kazunari Yoshida
BACKGROUND: Primary intracranial rhabdomyosarcoma is a very rare malignant tumor. Due to moderately vascular and firm characteristics of the tumor, complete removal without complications is often difficult. Moreover, in pediatric patients, the volume of total blood is less than adults and minimal intraoperative hemorrhage is desirable. CASE DESCRIPTION: A 6-year-old boy presented with ataxia and was found to have a large cerebellopontine angle tumor and hydrocephalus...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775726/pathological-effects-of-concurrent-administration-of-aflatoxin-b-1-and-fowl-adenovirus-4-in-broiler-chicks
#8
Muhammad Noman Naseem, Muhammad Kashif Saleemi, Ahrar Khan, Aisha Khatoon, Shafia Tehseen Gul, Farzana Rizvi, Ijaz Ahmad, Ahad Fayyaz
The current study was designed to investigate pathological effects fowl adenovirus in broilers exposed to aflatoxin B1 . Fowl Adenovirus-4 (FAdV-4) infection is remerging in all types of poultry birds in Pakistan. Poultry feed contamination with mycotoxin (aflatoxin) is another important global issue. A total of 125 a-day old broiler birds were divided into six equal groups. Group A served as control. B and C groups were administered with aflatoxin B1 (AFB1 ) 100 and 200 μg/kg feed. Group D was infected with FAdV-4 while groups E and F administered with both AFB1 (100 & 200 μg/kg) along with FAdV-4...
May 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29774877/-analysis-of-prognostic-factors-for-survival-in-elderly-patients-with-glioma
#9
Jinghui Liu, Miao Lou, Peigang Ji, Chen Li, Fuqiang Feng, Baofu Li, Meng Xu, Guodong Gao, Yan Qu, Liang Wang
To analyze the prognostic factors for survival in elderly patients with glioma.
 Methods: We performed a retrospective analysis of prognostic factors for elderly patients with glioma, who were treated by the same attending doctor during June 2014 and June 2016, to investigate the correlations of the age, dimension of pathology, histological grade, extent of resection, adjuvant therapy, preoperative Karnofsky Performance Scale (KPS) score, postoperative KPS score, molecular markers [isocitrate dehydrogenase-1 (IDH-1), O6-methylguanine DNA-transferase (MGMT), epidermal growth factor receptor (EGFR), Ki-67] with the prognosis...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29772616/-recurrent-urothelial-carcinoma-in-the-uretero-vesical-junction-treated-with-partial-ureterectomy-and-ureteroneocystostomy-during-long-term-follow-up-a-case-report
#10
Soichiro Shimura, Kazumasa Matsumoto, Ken-Ichi Tabata, Tetsuo Fujita, Masatsugu Iwamura
A 54-year-old woman who had been treated with transurethral resection of bladder tumor for nonmuscle invasive urothelial carcinoma approximately nine years before presented with gross hematuria. Cystoscopy demonstrated a papillary tumor at the left side of the ureteral orifice. Magnetic resonance imaging showed a 1.3 cm non-muscle invasive lesion in the lower ureter from the ureteral orifice. She suffered from connective tissue disease treated with steroids. To avoid renal failure, we performed partial ureterectomy and ureteroneocystostomy...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29770223/profound-hearing-loss-following-surgery-in-pediatric-patients-with-posterior-fossa-low-grade-glioma
#11
Yahya Ghazwani, Ibrahim Qaddoumi, Johnnie K Bass, Shengjie Wu, Jason Chiang, Frederick Boop, Amar Gajjar, Zsila Sadighi
Background: Hearing loss may occur in patients with posterior fossa low-grade glioma who undergo surgery. Methods: We retrospectively reviewed 217 patients with posterior fossa low-grade glioma, including 115 for whom results of hearing tests performed after surgery and before chemotherapy or radiation therapy were available. We explored the association of UHL with age at diagnosis, sex, race, tumor location, extent of resection, posterior fossa syndrome, ventriculoperitoneal shunt placement, and histology...
May 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29769033/case-report-on-pathogenetic-link-between-gluten-and-iga-nephropathy
#12
Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù, Domenico Santoro
BACKGROUND: A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time. CASE PRESENTATION: A 39-year-old man with cystic fibrosis (CF) and CF-related diabetes started to present gross hematuria, back pain and headache. At admission, laboratory analysis showed increase in serum creatinine of 1.5 mg/dl, together with hematuria and mild proteinuria (1 g/24 h). He underwent a renal biopsy to investigate the cause of hematuria and renal failure...
May 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29768979/mesoporous-silica-nanoparticle-is-comparatively-safer-than-zinc-oxide-nanoparticle-which-can-cause-profound-steroidogenic-effects-on-pregnant-mice-and-male-offspring-exposed-in-utero
#13
Nisha Bara, M Eshwarmoorthy, Kesavan Subaharan, Gautam Kaul
The increasing use of nanomaterials has naturally caused heightened concerns about their potential risks to human and animal health. We investigated the effect of zinc oxide nanoparticles (ZnO NPs) and mesoporous silica nanoparticles (MSN) on steroidogenesis in the corpus luteum (CL) of pregnant mice and testis of male offspring. Pregnant albino mice were exposed to ZnO NPs and MSN for 2 days on alternate days, gestation days 15-19. Hepatic injury marker enzymes increased in the higher concentration of NM-exposed mother mice, but histological examination revealed no changes in the placenta of pregnant mice, whereas testis of male offspring showed gross pathological changes...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29767278/the-hypothalamus-and-neuropsychiatric-disorders-psychiatry-meets-microscopy
#14
REVIEW
Hans-Gert Bernstein, Henrik Dobrowolny, Bernhard Bogerts, Gerburg Keilhoff, Johann Steiner
The past decades have witnessed an explosion of knowledge on brain structural abnormalities in schizophrenia and depression. Focusing on the hypothalamus, we try to show how postmortem brain microscopy has contributed to our understanding of mental disease-related pathologic alterations of this brain region. Gross anatomical abnormalities (volume changes of the third ventricle, the hypothalamus, and its nuclei) and alterations at the cellular level (loss of neurons, increased or decreased expression of hypothalamic peptides such as oxytocin, vasopressin, corticotropin-releasing hormone, and other regulatory factors as well as of enzymes involved in neurotransmitter and neuropeptide metabolism) have been reported in schizophrenia and/or depression...
May 16, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29767061/biochemical-and-histopathological-changes-in-sheep-fed-different-detoxified-karanj-pongamia-glabra-seed-cake-as-partial-protein-supplements
#15
Nira M Soren, Anil K Sharma, Vadali R B Sastry
The study investigated the long-term effect of feeding processed solvent extracted karanj ( Pongamia glabra ) cake (SKC) on gross pathology and histopathological changes in some vital organs, and on the activities of serum enzymes in Jalauni lambs. Twenty-four male lambs were divided into 4 groups and allotted randomly to a soybean meal (SBM) based control (CON) and 3 treatment groups receiving concentrate mixtures, containing water washed (WW), 2.5% lime (LM) and 0.4% binder (BN) treated SKC replacing 50% nitrogen of SBM to meet the protein requirements...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29765825/early-career-surgical-practice-for-cerebellopontine-angle-tumors-in-the-era-of-radiosurgery
#16
Giannantonio Spena, Tommaso Sorrentino, Roberto Altieri, Luca Redaelli de Zinis, Roberto Stefini, Pier Paolo Panciani, Marco Fontanella
We analyzed the outcomes of patients with large cerebellopontine angle (CPA) tumors treated by a skull-base team in which two surgeons (one neurosurgeon and one otological surgeon) were in the beginning of their careers (<40 years old). Data of patients operated on between April 2012 and March 2016 were reviewed. All factors related to surgical training were considered. Thirty-one patients had vestibular schwannomas, while 26 had meningiomas. Mean tumor diameter was 30.6 mm (range, 23-49 mm) for schwannomas and 35 mm (range, 22-51 mm) for meningiomas...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29764242/morbidity-and-mortality-resulting-from-acute-inhalation-exposures-to-hydrogen-fluoride-and-carbonyl-fluoride-in-rats
#17
Adolph J Januszkiewicz, Matthew A Bazar, Lee C B Crouse, Michael A Chapman, Steven E Hodges, Steven J McCormick, Arthur J O'Neill
OBJECTIVE: Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF2 ). METHODS: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF2 . Respiration was monitored before, during, and after exposure. Animals were observed up to 6 days post-exposure. Terminal blood samples were collected for routine clinical chemistry and hematology...
May 15, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29763815/gait-pathology-subtypes-are-not-associated-with-self-reported-fall-frequency-in-children-with-cerebral-palsy
#18
Elizabeth R Boyer, Aleksys Patterson
BACKGROUND: Trips and falls are common concerns reported by parents of children with cerebral palsy. Specific gait pathologies (excessive internal hip rotation, intoeing, and stiff knee gait) are anecdotally associated with higher rates of falls. RESEARCH QUESTION: Is fall frequency higher for the aforementioned gait pathologies? METHODS: Parent-reported fall frequency from 1063 children with cerebral palsy who also had a three-dimensional gait analysis was retrospectively reviewed...
May 5, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29763717/hepatic-micrometastases-are-associated-with-poor-prognosis-in-patients-with-liver-metastases-from-neuroendocrine-tumors-of-the-digestive-tract
#19
William E Gibson, Raul S Gonzalez, Justin M M Cates, Eric Liu, Chanjuan Shi
Pathologic examination of hepatic metastasectomies from patients with metastatic small intestinal or pancreatic neuroendocrine tumor frequently reveals micrometastases undetectable by radiologic or macroscopic gross examination. This finding raises the possibility that undetectable micrometastases remain in these patients after metastasectomy. Here we examined liver resections for micrometastases and assessed their impact on prognosis. Hepatic metastasectomies from 65 patients with neuroendocrine tumor of the small intestine (N=43) or pancreas (N=22) were reviewed for the presence of micrometastases, which were defined as microscopic tumor foci ≤1mm in greatest dimension...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29760202/survey-of-human-chromosome-21-gene-expression-effects-on-early-development-in-danio-rerio
#20
Sarah Edie, Norann A Zaghloul, Carmen C Leitch, Donna K Klinedinst, Janette Lebron, Joey F Thole, Andrew S McCallion, Nicholas Katsanis, Roger H Reeves
Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS), one of the most genetically complex conditions compatible with human survival. Assessment of the physiological consequences of dosage-driven overexpression of individual Hsa21 genes during early embryogenesis and the resulting contributions to DS pathology in mammals are not tractable in a systematic way. A recent study looked loss-of-function of C. elegans orthologues of Hsa21 genes and identified ten candidates with behavioral phenotypes, but the equivalent over-expression experiment has not been done...
May 14, 2018: G3: Genes—Genomes—Genetics
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