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https://www.readbyqxmd.com/read/28300615/heritability-of-brain-activity-related-to-response-inhibition-a-longitudinal-genetic-study-in-adolescent-twins
#1
Andrey P Anokhin, Simon Golosheykin, Julia D Grant, Andrew C Heath
The ability to inhibit prepotent but context- or goal-inappropriate responses is essential for adaptive self-regulation of behavior. Deficits in response inhibition, a key component of impulsivity, have been implicated as a core dysfunction in a range of neuropsychiatric disorders such as ADHD and addictions. Identification of genetically transmitted variation in the neural underpinnings of response inhibition can help to elucidate etiological pathways to these disorders and establish the links between genes, brain, and behavior...
March 11, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28272130/pharmacological-treatment-of-adhd-in-addicted-patients-what-does-the-literature-tell-us
#2
Pieter-Jan Carpentier, Frances R Levin
LEARNING OBJECTIVES: After participating in this activity, learners should be better able to:• Evaluate pharmacologic treatment of attention deficit/hyperactivity disorder (ADHD) in patients with substance use disorder (SUD) • Assess the causes of the diminished efficacy of ADHD medication in patients with comorbid SUD OBJECTIVE: Substance use disorder (SUD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur, and the presence of ADHD complicates the treatment of the addiction...
March 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28266244/psychopathological-temperamental-and-characteristic-factors-in-adults-with-remaining-childhood-attention-deficit-hyperactivity-symptoms
#3
Kyoung Min Kim, Sojeong Nam, Soo Yeon Kim, Soo Min Lee, Jae-Won Choi, Taewoong Kang, Jun Won Kim
OBJECTIVES: To investigate differences in psychopathological, temperamental and characteristic factors between young adults with and without persistent Attention-Deficit Hyperactivity disorder (ADHD) symptoms. METHODS: A total of 429 university students were divided into three groups: persistent adult ADHD (n = 53), only childhood ADHD (n = 56) and healthy controls (n = 320). The Korean Adult ADHD Scale, Korean Wender-Utah Rating Scale, Beck Depression Inventory-II, Beck Anxiety Inventory, Barratt Impulsiveness Scale, Korean Young Internet Addiction Scale, and Temperament Character Inventory-Revised (TCI-R; based on Cloninger's seven factor model of temperament and character) were used to evaluate psychopathological factors...
March 7, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28251590/towards-precision-addiction-treatment-new-findings-in-co-morbid-substance-use-and-attention-deficit-hyperactivity-disorders
#4
REVIEW
Sean X Luo, Frances R Levin
Attention-deficit hyperactivity disorder (ADHD) and substance use disorders (SUDs) may have common etiologies. ADHD is more prevalent in patients with substance use disorders, and this pattern is consistent across different substances of abuse. Individuals with SUDs and ADHD exhibit significant variations in their clinical presentations. The developmental trajectory of ADHD to SUDs is complex: ADHD symptoms appear first in some patients but not in others. Many patients present with a heterogeneous collection of psychiatric and substance use co-morbidities, and these symptoms change over time...
March 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28245666/social-skills-deficits-and-their-association-with-internet-addiction-and-activities-in-adolescents-with-attention-deficit-hyperactivity-disorder
#5
Wen-Jiun Chou, Mei-Feng Huang, Yu-Ping Chang, Yu-Min Chen, Huei-Fan Hu, Cheng-Fang Yen
Background and aims The aims of this study were to examine the association between social skills deficits and Internet addiction and activities in adolescents with attention-deficit/hyperactivity disorder (ADHD) as well as the moderators for this association. Methods A total of 300 adolescents, aged between 11 and 18 years, who had been diagnosed with ADHD participated in this study. Their Internet addiction levels, social skills deficits, ADHD, parental characteristics, and comorbidities were assessed. The various Internet activities that the participants engaged in were also examined...
March 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28228718/current-concepts-on-the-physiopathological-relevance-of-dopaminergic-receptors
#6
REVIEW
Ada Ledonne, Nicola B Mercuri
Dopamine (DA) is a key neurotransmitter modulating essential functions of the central nervous system (CNS), like voluntary movement, reward, several cognitive functions and goal-oriented behaviors. The factual relevance of DAergic transmission can be well appreciated by considering that its dysfunction is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD) and associated movement disorders, as well as, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28223929/the-effects-of-age-from-young-to-middle-adulthood-and-gender-on-resting-state-functional-connectivity-of-the-dopaminergic-midbrain
#7
Andrew C Peterson, Sheng Zhang, Sien Hu, Herta H Chao, Chiang-Shan R Li
Dysfunction of the dopaminergic ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) is implicated in psychiatric disorders including attention-deficit/ hyperactivity disorder (ADHD), addiction, schizophrenia and movement disorders such as Parkinson's disease (PD). Although the prevalence of these disorders varies by age and sex, the underlying neural mechanism is not well understood. The objective of this study was to delineate the distinct resting state functional connectivity (rsFC) of the VTA and SNc and examine the effects of age, from young to middle-adulthood, and sex on the rsFC of these two dopaminergic structures in a data set of 250 healthy adults (18-49 years of age, 104 men)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28174127/altered-functional-connectivity-in-default-mode-network-in-internet-gaming-disorder-influence-of-childhood-adhd
#8
Deokjong Lee, Junghan Lee, Jung Eun Lee, Young-Chul Jung
OBJECTIVE: Internet gaming disorder (IGD) is a type of behavioral addiction characterized by abnormal executive control, leading to loss of control over excessive gaming. Attention deficit and hyperactivity disorder (ADHD) is one of the most common comorbid disorders in IGD, involving delayed development of the executive control system, which could predispose individuals to gaming addiction. We investigated the influence of childhood ADHD on neural network features of IGD. METHODS: Resting-state functional magnetic resonance imaging analysis was performed on 44 young, male IGD subjects with and without childhood ADHD and 19 age-matched, healthy male controls...
April 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28145657/comparison-of-qeeg-findings-between-adolescents-with-attention-deficit-hyperactivity-disorder-adhd-without-comorbidity-and-adhd-comorbid-with-internet-gaming-disorder
#9
Jeong Ha Park, Ji Sun Hong, Doug Hyun Han, Kyoung Joon Min, Young Sik Lee, Baik Seok Kee, Sun Mi Kim
Internet gaming disorder (IGD) is often comorbid with attention deficit hyperactivity disorder (ADHD). In this study, we compared the neurobiological differences between ADHD comorbid with IGD (ADHD+IGD group) and ADHD without comorbidity (ADHD-only group) by analyzing quantitative electroencephalogram (QEEG) findings. We recruited 16 male ADHD+IGD, 15 male ADHD-only adolescent patients, and 15 male healthy controls (HC group). Participants were assessed using Young's Internet Addiction Scale and ADHD Rating Scale...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28139537/are-childhood-externalizing-disorders-the-harbinger-of-early-onset-alcohol-dependence
#10
Abhishek Ghosh, Savita Malhotra, Debasish Basu
BACKGROUND & OBJECTIVES: The subtyping of alcohol dependence (AD) into early-onset (EO) and late-onset (LO) subgroups has been shown to have clinical and biological validity. As externalizing disorders (EDs) predate AD, the link of ED with age of onset of alcohol dependence needs to be investigated. The aim of this study was to examine the relationship of EDs such as disruptive behaviour disorder (DBD) and attention deficit hyperactivity disorder (ADHD) with age at onset of AD in a sample of male subjects...
September 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28106934/neuroimaging-the-neural-correlates-of-increased-risk-for-substance-use-disorders-in-attention-deficit-hyperactivity-disorder-a-systematic-review
#11
REVIEW
Vitria Adisetiyo, Kevin M Gray
BACKGROUND/OBJECTIVES: Children with attention-deficit/hyperactivity disorder (ADHD) are nearly three times more likely to develop substance use disorders (SUD) than their typically developing peers. Our objective was to review the existing neuroimaging research on high-risk ADHD (ie, ADHD with disruptive behavior disorders, familial SUD and/or early substance use), focusing on impulsivity as one possible mechanism underlying SUD risk. METHODS: A PubMed literature search was conducted using combinations of the keywords "ADHD," "substance use," "substance use disorder," "SUD," "addiction," "dependence," "abuse," "risk," "brain" "MRI," "imaging" and "neuroimaging...
March 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28051838/mixed-amphetamine-salts-increase-abstinence-from-marijuana-in-patients-with-co-occurring-attention-deficit-hyperactivity-disorder-and-cocaine-dependence
#12
Daniel P Notzon, John J Mariani, Martina Pavlicova, Andrew Glass, Amy L Mahony, Daniel J Brooks, John Grabowski, Frances R Levin
BACKGROUND AND OBJECTIVES: The prevalence of ADHD is greater in substance use disorders than the general population, and ADHD and substance use disorders share neurobiological features such as dysregulation of reward circuitry. We tested the hypothesis that stimulants would decrease marijuana use in a randomized controlled trial of extended release mixed amphetamine salts (MAS-XR) for treatment of co-occurring ADHD and cocaine use disorders. METHODS: Marijuana users were defined as participants reporting use in the 30 days before study initiation, collected with timeline follow-back...
December 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/27997065/depression-and-severity-of-substance-dependence-among-heroin-dependent-patients-with-adhd-symptoms
#13
Yin-To Liao, Chi-Yen Chen, Mei-Hing Ng, Kuo-You Huang, Wen-Chuan Shao, Tsang-Yaw Lin, Vincent Chin-Hung Chen, Michael Gossop
BACKGROUND AND OBJECTIVES: Comorbid attention deficit hyperactivity disorder (ADHD) symptoms are highly prevalent among heroin-dependent patients. We aim to investigate differences in dependence severity, depression, and quality of life between heroin-dependent patients with and without ADHD-screened positive. METHODS: Heroin-dependent participants (n = 447) entering methadone maintenance treatment were divided into ADHD-screened positive (ADHD-P) and ADHD-screened negative (ADHD-N) groups according to scores of Adult ADHD Self-Report Scale (ASRS)...
January 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/27991999/attention-deficit-hyperactivity-disorder-and-drug-addiction-rehabilitation-patients
#14
Carlos Henrique Ferreira Camargo, Tarcísio Fanha Dornelles, Karin Barszcz, Eduardo Antunes Martins
Objective: Attention deficit hyperactivity disorder (ADHD) is characterized by a persistent pattern of inattention or hyperactivity. This study aimed to investigate the relationship between ADHD and drug dependence. Methods: The presence and severity of ADHD and substance use were evaluated through questionnaires in 80 adult patients in therapeutic communities. Results: No difference in drug use or dependence prevalence between ADHD and non-ADHD patients was found...
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27943032/subtyping-non-treatment-seeking-problem-gamblers-using-the-pathways-model
#15
Miea Moon, Jamey J Lister, Aleks Milosevic, David M Ledgerwood
This study examined whether distinct subgroups could be identified among a sample of non-treatment-seeking problem and pathological/disordered gamblers (PG) using Blaszczynski and Nower's (Addiction 97:487-499, 2002) pathways model (N = 150, 50% female). We examined coping motives for gambling, childhood trauma, boredom proneness, risk-taking, impulsivity, attention-deficit/hyperactivity disorder (ADHD), and antisocial personality disorder as defining variables in a hierarchical cluster analysis to identify subgroups...
December 10, 2016: Journal of Gambling Studies
https://www.readbyqxmd.com/read/27895485/adhd-and-present-hedonism-time-perspective-as-a-potential-diagnostic-and-therapeutic-tool
#16
REVIEW
S Weissenberger, M Klicperova-Baker, P Zimbardo, K Schonova, D Akotia, J Kostal, M Goetz, J Raboch, R Ptacek
The article draws primarily from the behavioral findings (mainly psychiatric and psychological observations) and points out the important relationships between attention-deficit/hyperactivity disorder (ADHD) symptoms and time orientation. Specifically, the authors argue that there is a significant overlap between the symptoms of ADHD and Present Hedonism. Present Hedonism is defined by Zimbardo's time perspective theory and assessed by Zimbardo Time Perspective Inventory. Developmental data on Present Hedonism of males and females in the Czech population sample (N=2201) are also presented...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27866153/exploring-personality-and-readiness-to-change-in-patients-with-substance-use-disorders-with-and-without-adhd
#17
L Flores-García, E Ytterstad, M B Lensing, M Eisemann
OBJECTIVE: To explore personality and readiness to change among substance use disorders (SUD) patients with and without ADHD. METHOD: SUD + ADHD versus SUD - ADHD patients consecutively entering treatment between 2010 and 2012 were compared concerning personality (Temperament and Character Inventory) and readiness to change (Stages of Change Readiness and Treatment Eagerness Scale). RESULTS: Among 103 SUD patients (76 men, age M = 43.3, SD = 11...
November 19, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27859666/effectiveness-of-atomoxetine-and-methylphenidate-for-problematic-online-gaming-in-adolescents-with-attention-deficit-hyperactivity-disorder
#18
Jeong Ha Park, Young Sik Lee, Ji Hyun Sohn, Doug Hyun Han
OBJECTIVE: There is a high prevalence of problematic online gaming in adolescents with attention deficit hyperactivity disorder (ADHD). In the current study, we compared the effectiveness of atomoxetine (ATM) and methylphenidate (MPH) on problematic online gaming in adolescents with ADHD. METHODS: We recruited 86 adolescents diagnosed with ADHD together with Internet gaming disorder. These participants were divided into two treatment groups: 44 participants were treated with MPH for 12 weeks, and 42 participants were treated with ATM for 12 weeks...
November 2016: Human Psychopharmacology
https://www.readbyqxmd.com/read/27842945/addiction-severity-pattern-associated-with-adult-and-childhood-attention-deficit-hyperactivity-disorder-adhd-in-patients-with-addictions
#19
Melina Fatséas, Hortense Hurmic, Fuschia Serre, Romain Debrabant, Jean-Pierre Daulouède, Cécile Denis, Marc Auriacombe
Attention Deficit Hyperactivity Disorder (ADHD) is highly prevalent among adults with addictive disorders, but little is known about addiction patterns associated with ADHD diagnosis. This study examined addiction severity in patients with co-occurring addictive disorders and ADHD controlling for the potential influence of associated psychiatric comorbidity. Data were collected in French outpatient addiction treatment centers. A total of 217 patients seeking treatment for substance or gambling addiction were included...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27824233/cigarette-smoking-and-adhd-an-examination-of-prognostically-relevant-smoking-behaviors-among-adolescents-and-young-adults
#20
Jessica D Rhodes, William E Pelham, Elizabeth M Gnagy, Saul Shiffman, Karen J Derefinko, Brooke S G Molina
Attention-deficit/hyperactivity disorder (ADHD) is associated with health risks in adolescence which includes the potential for smoking cigarettes, early smoking initiation, and rapid progression to daily smoking. Much less is known, however, about prognostically relevant smoking behaviors among individuals with childhood ADHD. Further research in this area is important for identifying individuals at pronounced risk for nicotine addiction, and for developing effective interventions for this population. This study examined initiation of cigarette smoking, progression to regular smoking, quantity of use, indicators of tobacco dependence, and quit rates among adolescents and young adults with (n = 364) and without (n = 240) childhood ADHD...
August 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
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