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https://www.readbyqxmd.com/read/29336618/rheumatoid-arthritis-a-single-center-egyptian-experience
#1
B R Sakr, M M Elfishawi, M H ElArousy, A K Hatw, A N AbdulKarim, A B Tammam, A N Kotp, M E Hamed, I E Genedy, E D El Desouky, Z O Nawito
OBJECTIVE: Demonstration of rheumatoid arthritis (RA) characteristics in a large cohort of Egyptian patients. METHODS: Retrospective analysis of data of 3219 RA patients attending the Rheumatology outpatient clinic, Kasr Alainy Hospital, Cairo University; from January 1995 till December 2015. RESULTS: Mean age at disease onset was 36.1 ±13.4 years; 2774 (84%) were females and mean disease duration was 12.9 ±7.9 years. Regarding number of joint affected at disease onset; polyarticular pattern was found in 77...
January 16, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29335779/equine-neutrophils-and-their-role-in-ischemia-reperfusion-injury-and-lung-inflammation
#2
REVIEW
Stacy L Anderson, Baljit Singh
Horses are susceptible to a multitude of inflammatory conditions that are characterized by a strong neutrophilic response. Here, we review basic equine neutrophil biology and explore the role of neutrophils in inflammatory conditions with emphasis on intestinal ischemia and reperfusion injury and lung inflammation. In addition, unique aspects of equine neutrophil biology have been highlighted. Neutrophils comprise the highest proportion of circulating white blood cells in equine blood. The concentration of circulating equine neutrophils is a primary indicator of systemic inflammation...
January 15, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29334814/dual-ligand-modified-liposomes-provide-effective-local-targeted-delivery-of-lung-cancer-drug-by-antibody-and-tumor-lineage-homing-cell-penetrating-peptide
#3
Congcong Lin, Xue Zhang, Hubiao Chen, Zhaoxiang Bian, Ge Zhang, Muhammad Kashif Riaz, Deependra Tyagi, Ge Lin, Yanbo Zhang, Jinjin Wang, Aiping Lu, Zhijun Yang
The abilities of a drug delivery system to target and penetrate tumor masses are key factors in determining the system's chemotherapeutic efficacy. Here, we explored the utility of an anti-carbonic anhydrase IX (anti-CA IX) antibody and CPP33 dual-ligand modified triptolide-loaded liposomes (dl-TPL-lip) to simultaneously enhance the tumor-specific targeting and increase tumor cell penetration of TPL. In vitro, the dl-TPL-lip increased the cytotoxicity of TPL in CA IX-positive lung cancer cells, which showed tunable size (137...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29331643/glucagon-like-peptide-1-signaling-inhibits-allergen-induced-lung-il-33-release-and-reduces-group-2-innate-lymphoid-cell-ilc2-cytokine-production-in-vivo
#4
Shinji Toki, Kasia Goleniewska, Sara Reiss, Jian Zhang, Melissa H Bloodworth, Matthew T Stier, Weisong Zhou, Dawn C Newcomb, Lorraine B Ware, Gregg D Stanwood, Aurelio Galli, Kelli L Boyd, Kevin D Niswender, R Stokes Peebles
BACKGROUND: IL-33 is one of the most consistently associated gene candidates for asthma identified by GWAS. Studies in mice and in human cells have confirmed the importance of IL-33 in inducing type-2 cytokine production from both group 2 innate lymphoid cells (ILC2) and Th2 cells. However, there are no pharmacologic agents known to inhibit IL-33 release from airway cells. OBJECTIVE: To determine the effect of glucagon like peptide receptor-1 GLP-1R signaling on aeroallergen-induced airway IL-33 production and release and on innate type-2 airway inflammation...
January 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29326144/a-new-secretory-peptide-of-natriuretic-peptide-family-osteocrin-suppresses-the-progression-of-congestive-heart-failure-after-myocardial-infarction
#5
Takahiro Miyazaki, Kentaro Otani, Ayano Chiba, Hirohito Nishimura, Takeshi Tokudome, Haruko Watanabe-Takano, Ayaka Matsuo, Hiroyuki Ishikawa, Keiko Shimamoto, Hajime Fukui, Yugo Kanai, Akihiro Yasoda, Soshiro Ogata, Kunihiro Nishimura, Naoto Minamino, Naoki Mochizuki
Rationale: An increase of severe ischemic heart diseases results in an increase of the patients with congestive heart failure (CHF). Therefore, new therapies are expected in addition to recanalization of coronary arteries. Previous clinical trials using natriuretic peptides (NPs) prove the improvement of CHF by NPs. Objective: We aimed at investigating whether osteocrin (OSTN) peptide potentially functioning as an NP clearance receptor (NPR3)-blocking peptide can be used as a new therapeutic peptide for treating CHF after myocardial infarction (MI) using animal models...
January 11, 2018: Circulation Research
https://www.readbyqxmd.com/read/29322917/identification-of-natural-antimicrobial-peptides-from-bacteria-through-metagenomic-and-metatranscriptomic-analysis-of-high-throughput-transcriptome-data-of-taiwanese-oolong-teas
#6
Kai-Yao Huang, Tzu-Hao Chang, Jhih-Hua Jhong, Yu-Hsiang Chi, Wen-Chi Li, Chien-Lung Chan, K Robert Lai, Tzong-Yi Lee
BACKGROUND: Anti-microbial peptides (AMPs), naturally encoded by genes and generally containing 12-100 amino acids, are crucial components of the innate immune system and can protect the host from various pathogenic bacteria and viruses. In recent years, the widespread use of antibiotics has resulted in the rapid growth of antibiotic-resistant microorganisms that often induce critical infection and pathogenesis. Recently, the advent of high-throughput technologies has led molecular biology into a data surge in both the amount and scope of data...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29321936/low-voltage-electricity-induced-lung-injury
#7
Thai Truong, Thuong Vu Le, David L Smith, Stephen P Kantrow, Van Ngoc Tran
We report a case of bilateral pulmonary infiltrates and haemoptysis following low-voltage electricity exposure in an agricultural worker. A 58-year-old man standing in water reached for an electric watering machine and sustained an exposure to 220 V circuit for an uncertain duration. The electricity was turned off by another worker, and the patient was asymptomatic for the next 10 h until he developed haemoptysis. A chest radiograph demonstrated bilateral infiltrates, and chest computed tomography (CT) revealed ground-glass opacities with interstitial thickening...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29306507/immunogenicity-and-safety-of-a-novel-tetanus-toxoid-conjugated-anti-gastrin-vaccine-in-balb-c-mice
#8
Qing He, Hua Gao, Meng Gao, Shengmei Qi, Kun Yang, Yingqi Zhang, Junzhi Wang
The objective of this study is to determine the immunogenicity and safety of our novel anti-gastrin vaccine that is composed of the common amino-terminal portions of human carboxy-amidated gastrin-17 (G17) and glycine-extended gastrin-17 (gly-G17) as well as the common carboxy-terminal portion of the gastrin precursor progastrin (in a 50:50 mixture) all covalently linked to tetanus toxoid (TT) via peptide spacers. The vaccine, or immunogen, was injected intramuscularly into the legs of BALB/c mice, which produced high serum titres of specific IgG antibodies and IFN-γ in their spleen cells, identifiable by enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunospot assay (ELISPOT), respectively...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29301525/annexin-a1-in-plasma-from-patients-with-bronchial-asthma-its-association-with-lung-function
#9
Sun-Hye Lee, Pureun-Haneul Lee, Byeong-Gon Kim, Hyun-Jeong Seo, Ae-Rin Baek, Jong-Sook Park, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
BACKGROUND: Annexin-A1 (ANXA1) is a glucocorticoid-induced protein with multiple actions in the regulation of inflammatory cell activation. The anti-inflammatory protein ANXA1 and its N-formyl peptide receptor 2 (FPR2) have protective effects on organ fibrosis. However, the exact role of ANXA1 in asthma remains to be determined. The aim of this study was to identify the role of ANXA1 in bronchial asthma. METHODS: In mice sensitized and challenged with ovalbumin (OVA-OVA mice) and mice sensitized with saline and challenged with air (control mice), we investigated the potential links between ANXA1 levels and bronchial asthma using ELISA, immunoblotting, and immunohistochemical staining...
January 4, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29299146/targeting-chaperonin-containing-tcp1-cct-as-a-molecular-therapeutic-for-small-cell-lung-cancer
#10
Ana C Carr, Amr S Khaled, Rania Bassiouni, Orielyz Flores, Daniel Nierenberg, Hammad Bhatti, Priya Vishnubhotla, J Perez Manuel, Santimukul Santra, Annette R Khaled
Identifying new druggable targets is desired to meet the needs for effective cancer treatments. To this end, we previously reported the efficacy of a therapeutic peptide called CT20p that displays selective cytotoxicity through inhibition of a multi-subunit, protein-folding complex called Chaperonin-Containing TCP-1 (CCT). To investigate the role of CCT in cancer progression, we examined protein levels of CCT subunits in liver, prostate, and lung cancer using human tissue microarrays. We found that these cancers expressed higher levels of CCT2 as compared to normal tissues...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29296227/effects-of-three-il-15-variants-on-nci-h446-cell-proliferation-and-expression-of-cell-cycle-regulatory-molecules
#11
Jun-Ying Ding, Zhi-Hua Wang, Zheng-Zheng Zhang, Xu-Ran Cui, Yan-Ying Hong, Qing-Quan Liu
Interleukin 15 (IL-15) is a cytokine exhibiting antitumor characteristic similar to that of IL-2. However, in human tissues and cells, IL-15 expression and secretion is very limited, suggesting IL-15 functions mainly intracellularly. In the present study, we assessed the effects of transfecting NCI-H446 small cell lung cancer cells with genes encoding three IL-15 variants: prototypical IL-15, mature IL-15 peptide, and modified IL-15 in which the IL-2 signal peptide is substituted for the native signal peptide...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29296216/calsyntenin-1-clusterin-and-neutrophil-gelatinase-associated-lipocalin-are-candidate-serological-biomarkers-for-lung-adenocarcinoma
#12
Yen Chu, Yu-Heng Lai, Ming-Cheng Lee, Yu-Jung Yeh, Yao-Kuang Wu, Wayne Tsao, Chun-Yao Huang, Semon Wu
It has been drawn attention that secreted proteins with signal peptide from cancer cells provide new potential biomarkers of cancer. In this study, three lung adenocarcinoma cell lines and serum samples from 20 patients were used for identifying potential serologic tumor biomarker with proteomic and bioinformatics approaches. One-dimensional electrophoresis, and identified with mass spectrometry and database research were performed. We found17 secreted proteins in common, while another 17 proteins with signal peptide were identified in all three lung adenocarcinoma cell lines alone with patient samples...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288742/the-research-of-the-possible-mechanism-and-the-treatment-for-capsaicin-induced-cough
#13
Li Zhang, Tieying Sun, Longteng Liu, Lifang Wang
Unexplained chronic cough (UCC) affects millions of patients worldwide. New therapeutic approaches to this condition are urgently needed, since current treatment options provide only symptomatic relief. Cough reflex hypersensitivity has been shown to play an important role in the pathogenesis of UCC. The transient receptor potential vanilloid type 1 (TRPV1) is present on peripheral terminals of airway sensory nerves and modulation of its activity represents a potential target for the pharmacological treatment of UCC...
December 27, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29287593/upregulation-of-citrullination-pathway-from-autoimmune-to-idiopathic-lung-fibrosis
#14
Katerina D Samara, Athina Trachalaki, Eliza Tsitoura, Anastasios V Koutsopoulos, Eleni D Lagoudaki, Ismini Lasithiotaki, George Margaritopoulos, Panagiotis Pantelidis, Eleni Bibaki, Nikolaos M Siafakas, Nikolaos Tzanakis, Athol U Wells, Katerina M Antoniou
BACKGROUND: Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps towards autoimmunity. Approximately, 10% of RA patients develop clinically significantly ILD. A possible shared role of protein citrullination in rheumatoid arthritis associated interstitial lung disease (RA-ILD), and idiopathic pulmonary fibrosis (IPF) pathogenesis remains unclear...
December 29, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29282039/plasma-levels-of-alarmin-hnps-1-3-associate-with-lung-dysfunction-after-cardiac-surgery-in-children
#15
XiWang Liu, QiXing Chen, YuJia Luo, YaoQin Hu, DengMing Lai, XiaoLe Zhang, XiangHong Zhang, JianGen Yu, XiangMing Fang, Qiang Shu
BACKGROUND: Early onset of lung injury is considerable common after cardiac surgery and is associated with increasing in morbidity and mortality, but current clinical predictors for the occurrence of this complication always have limited positive warning value. This study aimed to evaluate whether elevated plasma levels of human neutrophil peptides (HNPs) 1-3 herald impaired lung function in infants and young children after cardiac surgery necessitating cardiopulmonary bypass (CPB). METHODS: Consecutive children younger than 3 years old who underwent cardiac surgery were prospectively enrolled...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29281178/a-novel-anti-hypertensive-peptide-identified-in-thermolysin-digested-rice-bran
#16
Naohisa Shobako, Yutaro Ogawa, Atsushi Ishikado, Kayo Harada, Etsuko Kobayashi, Hirohisa Suido, Takeshi Kusakari, Mariko Maeda, Makoto Suwa, Motonobu Matsumoto, Ryuhei Kanamoto, Kousaku Ohinata
SCOPE: Hypertension is a risk factor for arteriosclerosis. In this study, we investigated the anti-hypertensive effect of protease-digested rice bran in a spontaneously hypertension rat (SHR) model. We also purified a novel anti-hypertensive peptide from the digest. METHODS AND RESULTS: Thermolysin-digested rice bran (TRB) was administered to SHRs for 4 weeks, and systolic blood pressure (SBP) was measured weekly using the tail-cuff method. TRB showed an anti-hypertensive effect in a dose-dependent manner...
December 27, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29280317/selective-cell-penetrating-peptide-functionalized-polymersomes-mediate-efficient-and-targeted-delivery-of-methotrexate-disodium-to-human-lung-cancer-in-vivo
#17
Weijing Yang, Yifeng Xia, Yuan Fang, Fenghua Meng, Jian Zhang, Ru Cheng, Chao Deng, Zhiyuan Zhong
It is a long challenge to develop nanomedicines that simultaneously possess tumor cell selectivity and penetration functions. Here, it is reported that selective cell penetrating peptide (RLWMRWYSPRTRAYGC)-functionalized polymersomes (SCPP-PS) mediate efficient and targeted delivery of methotrexate disodium (MTX) to human lung cancer in vivo. SCPP-PS with an SCPP density of 18.7% is self-crosslinked, has a small size (63-65 nm), and high MTX loading (up to 19.4 wt%), shows selective uptake and fast penetration into A549 lung cancer cells, and efficiently releases MTX intracellularly...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29278911/design-synthesis-and-biological-evaluation-of-68ga-dota-pa1-for-lung-cancer-a-novel-pet-tracer-for-multiple-somatostatin-receptors-imaging
#18
Fei Liu, Teli Liu, Xiaoxia Xu, Xiaoyi Guo, Nan Li, Chiyi Xiong, Chun Li, Hua Zhu, Zhi Yang
Most of the radiolabeled somatostatin analogues (SSAs) are specific for subtype somatostatin receptor 2 (SSTR2). Lack of ligands targeting other subtypes of SSTRs, especially SSTR1, SSTR3 and SSTR5, limited their applications in tumors of low SSTR2 expression, including lung tumor. In this study, we aimed to design and synthesize a positron emission tomography (PET) radiotracer targeting multi-subtypes of SSTRs for PET imaging. PA1 peptide and its conjugate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator or fluorescein isothiocyanate (FITC) at the N-terminal of the lysine position were synthesized...
December 27, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29277692/characterisation-of-signalling-and-regulation-of-common-calcitonin-receptor-splice-variants-and-polymorphisms
#19
Emma Dal Maso, Rasmus Just, Caroline Hick, Arthur Christopoulos, Patrick M Sexton, Denise Wootten, Sebastian G B Furness
The calcitonin receptor (CTR) is a class B G protein-coupled receptor that is a therapeutic target for the treatment of hypercalcaemia of malignancy, Paget's disease and osteoporosis. In primates, the CTR is subject to alternative splicing, with a unique, primate-specific splice variant being preferentially expressed in reproductive organs, lung and kidney. In addition, humans possess a common non-synonymous single-nucleotide polymorphism (SNP) encoding a proline/leucine substitution in the C-terminal tail...
December 22, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29276625/epicardial-delivery-of-autologous-atrial-appendage-micrografts-during-coronary-artery-bypass-surgery-safety-and-feasibility-study
#20
Annu Nummi, Tuomo Nieminen, Tommi Pätilä, Milla Lampinen, Miia L Lehtinen, Sari Kivistö, Miia Holmström, Erika Wilkman, Kari Teittinen, Mika Laine, Juha Sinisalo, Markku Kupari, Esko Kankuri, Tatu Juvonen, Antti Vento, Raili Suojaranta, Ari Harjula
Background: The atrial appendages are a tissue reservoir for cardiac stem cells. During on-pump coronary artery bypass graft (CABG) surgery, part of the right atrial appendage can be excised upon insertion of the right atrial cannula of the heart-lung machine. In the operating room, the removed tissue can be easily cut into micrografts for transplantation. This trial aims to assess the safety and feasibility of epicardial transplantation of atrial appendage micrografts in patients undergoing CABG surgery...
2017: Pilot and Feasibility Studies
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