keyword
MENU ▼
Read by QxMD icon Read
search

Phase three study

keyword
https://www.readbyqxmd.com/read/28823058/polyurethane-gelatin-nanofibrils-neural-guidance-conduit-containing-platelet-rich-plasma-and-melatonin-for-transplantation-of-schwann-cells
#1
Majid Salehi, Mahdi Naseri-Nosar, Somayeh Ebrahimi-Barough, Mohammdreza Nourani, Arash Khojasteh, Saeed Farzamfar, Korosh Mansouri, Jafar Ai
The current study aimed to enhance the efficacy of peripheral nerve regeneration using a biodegradable porous neural guidance conduit as a carrier to transplant allogeneic Schwann cells (SCs). The conduit was prepared from polyurethane (PU) and gelatin nanofibrils (GNFs) using thermally induced phase separation technique and filled with melatonin (MLT) and platelet-rich plasma (PRP). The prepared conduit had the porosity of 87.17 ± 1.89%, the contact angle of 78.17 ± 5.30° and the ultimate tensile strength and Young's modulus of 5...
August 19, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28822948/bacterial-and-archaeal-community-distribution-and-stabilization-of-anaerobic-sludge-in-a-strengthen-circulation-anaerobic-sca-reactor-for-municipal-wastewater-treatment
#2
Bo Yang, Hui Xu, Junfeng Wang, Xinshan Song, Yuhui Wang, Fang Li, Qing Tian, Chunyan Ma, Daoyuan Wang, Junhong Bai, Wolfgang Sand
In this study, a SCA reactor was employed for municipal wastewater treatment at a mesophilic temperature (30°C) under different hydraulic retention times (HRT) and upflow velocities (Vup) to investigate granule sludge stability and spatial microbial distribution. The stable COD removal efficiency readied at HRT of 15, 12, 9 and 6h, and Vup ranging from 0.6 to 5.9mh(-1). EPS fraction analysis of granule sludge shows that municipal wastewater was mainly attributed to the enrichment influence of polysaccharide and tightly bound-EPS...
August 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28822742/strategy-set-shifting-and-response-inhibition-in-adult-rats-exposed-to-an-environmental-polychlorinated-biphenyl-mixture-during-adolescence
#3
Supida Monaikul, Paul Eubig, Stan Floresco, Susan Schantz
Converging evidence from studies with animal models and humans suggests that early developmental exposure to polychlorinated biphenyls (PCBs) leads to deficits in cognitive flexibility and inhibitory control. These processes are mediated to a large extent by the prefrontal cortex, thus we examined the effects of PCB exposure during adolescence-a period of robust prefrontal cortical development-on both processes. Specifically, we used operant set-shifting and differential reinforcement of low rates of responding (DRL) tasks to assess cognitive flexibility and response inhibition, respectively...
August 16, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28822316/improved-middle-ear-soft-tissue-visualization-using-synchrotron-radiation-phase-contrast-imaging
#4
Mai Elfarnawany, Seyed Alireza Rohani, Soroush Ghomashchi, Daniel G Allen, Ning Zhu, Sumit K Agrawal, Hanif M Ladak
High resolution images are used as a basis for finite-element modeling of the middle-ear structures to study their biomechanical function. Commonly used imaging techniques such as micro-computed tomography (CT) and optical microscopy require extensive sample preparation, processing or staining using contrast agents to achieve sufficient soft-tissue contrast. We compare imaging of middle-ear structures in unstained, non-decalcified human temporal bones using conventional absorption-contrast micro-CT and using synchrotron radiation phase-contrast imaging (SR-PCI)...
August 5, 2017: Hearing Research
https://www.readbyqxmd.com/read/28822037/effect-of-initiation-time-of-hydrostatic-pressure-shock-on-chromosome-set-doubling-of-tetraploidization-in-turbot-scophthalmus-maximus
#5
Xiangping Zhu, Zhengmei Lin, Zhihao Wu, Jiandong Li, Feng You
The objective of the study was to clarify the effects of initiation time on chromosome set doubling induced by hydrostatic pressure shock through nuclear phase fluorescent microscopy in turbot Scophthalmus maximus. The ratio of developmentally delayed embryo and chromosome counting was used to assess induction efficiency. For the embryos subjected to a pressure of 67.5 MPa for 6 min at prometaphase (A group), chromosomes recovered to the pre-treatment condition after 11-min recovering. The first nuclear division and cytokinesis proceeded normally...
August 19, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28821473/feasibility-of-a-facebook-intervention-for-exercise-motivation-and-cardiac-rehabilitation-adherence-study-protocol
#6
Lee Anne Siegmund, Haitham M Ahmed, Michael Todd Crawford, James Frank Bena
BACKGROUND: While cardiac rehabilitation has been shown to be effective at improving coronary heart disease (CHD), participation is generally poor. Attempts to increase uptake and adherence often fail. Use of a Facebook intervention for this population may be a unique opportunity to support self-determined motivation and affect adherence. OBJECTIVE: To evaluate the impact of a Facebook intervention on motivation for exercise and adherence to cardiac rehabilitation in patients with CHD during a 12-week, Phase II cardiac rehabilitation program...
August 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28821347/stable-oil-laden-foams-formation-and-evolution
#7
REVIEW
Rémy Mensire, Elise Lorenceau
The interaction between oil and foam has been the subject of various studies. Indeed, oil can be an efficient defoaming agent, which can be highly valuable in various industrial applications where undesired foaming may occur, as seen in jet-dyeing processes or waste water treatment plant. However, oil and foam can also constructively interact as observed in detergency, fire-fighting, food and petroleum industries, where oil can be in the foam structure or put into contact with the foam without observing a catastrophic break-up of the foam...
August 2, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28821154/design-and-characterization-of-a-biocompatible-physical-hydrogel-based-on-scleroglucan-for-topical-drug-delivery
#8
Patrizia Paolicelli, Gabriele Varani, Settimio Pacelli, Elisa Ogliani, Martina Nardoni, Stefania Petralito, Alessandra Adrover, Maria Antonietta Casadei
Physical hydrogels of a high-carboxymethylated derivative of scleroglucan (Scl-CM300) were investigated as potential systems for topical drug delivery using three different therapeutic molecules (fluconazole, diclofenac and betamethasone). Rheological tests were carried out on drug-loaded hydrogels along with in-vitro release studies in a vertical Franz cell, in order to investigate if and how different drugs may influence the rheological and release properties of Scl-CM300 hydrogels. Experimental results and theoretical modeling highlighted that, in the absence of drug/polymer interactions (as for fluconazole and betamethasone) Scl-CM300 matrices offer negligible resistance to drug diffusion and a Fickian transport model can be adopted to estimate the effective diffusion coefficient in the swollen hydrogel...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820903/prominent-facilitation-at-beta-and-gamma-frequency-range-revealed-with-physiological-calcium-concentration-in-adult-mouse-piriform-cortex-in-vitro
#9
Marie Gleizes, Simon P Perrier, Caroline Fonta, Lionel G Nowak
Neuronal activity is characterized by a diversity of oscillatory phenomena that are associated with multiple behavioral and cognitive processes, yet the functional consequences of these oscillations are not fully understood. Our aim was to determine whether and how these different oscillatory activities affect short-term synaptic plasticity (STP), using the olfactory system as a model. In response to odorant stimuli, the olfactory bulb displays a slow breathing rhythm as well as beta and gamma oscillations...
2017: PloS One
https://www.readbyqxmd.com/read/28820773/self-care-management-in-corrections-perspectives-from-persons-with-an-incarceration-experience
#10
Annette T Maruca, Kimberly Dion, Adrial A Lobelo, Olivia Ampiah-Bonney, Chunfang Chen, Kirk Sanger, Donna Zucker
The purpose of this study was to explore the perceptions and beliefs of what self-care management looks like for a person with an incarceration experience. This is the first phase of a two-phase study. This qualitative study, held in three county jails in Massachusetts, utilized a focus group methodology. The Rediscovery of Self-Care: A Care Intervention for Persons with Incarceration Experience (RSC) model served as the framework for this study. On the basis of a priori constructs from the RSC model, a protocol was established and targeted questions outlined...
July 2017: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/28820614/protective-effects-of-cryoprotectants-and-lyoprotectants-on-the-survival-of-persipeptide-producing-streptomyces-zagrosensis-utmc-1154
#11
Fatemeh Mohammadipanah, Leila Parvizi, Javad Hamedi, Farzaneh Azizmohseni
Streptomyces sp. are bacteria recognized as the producers of more than half of the known bioactive compounds. Developing appropriate preservation methods for industrial strains of Streptomyces is necessary, as continuous subculture could have significant negative effects on their characteristics, including their potential to produce secondary metabolites. The effects of two common preservation methods on a bioactive metabolite producer, Streptomyces zagrosensis UTMC 1154, were studied. In the cryopreservation method, glycerol and dimethyl sulfoxide (DMSO) were evaluated as cryoprotectants...
August 18, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28820586/dissociation-chemistry-of-3-oxetanone-in-the-gas-phase
#12
Sumitra Godara, Pooja Verma, Manikandan Paranjothy
3-Oxetanone is a strained cyclic molecule which plays an important role in synthetic chemistry. A few studies exist in the literature about the equilibrium properties of this molecule and the dissociation patterns of substituted 3-oxetanones. For the unsubstituted 3-oxetanone, formation of ketene (CH2CO) and formaldehyde (HCHO) was considered to be the major dissociation pathway. In a recent work, pyrolysis products of 3-oxetanone molecule in the gas phase were investigated by Fourier transform infrared spectroscopy and photoionization mass spectrometry...
August 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28820043/rapid-removal-of-chloroform-carbon-tetrachloride-and-trichloroethylene-in-water-by-aluminum-iron-alloy-particles
#13
Jie Xu, Yuan Pu, Xiao Jin Yang, Pingyu Wan, Rong Wang, Peng Song, Adrian Fisher
Water contamination with chlorinated hydrocarbons such as chloroform (CHCl3), carbon tetrachloride (CCl4) and trichloroethylene (TCE) is one of the major public health concerns. In this study, we explored the use of aluminum-iron alloys particles in millimeter scale for rapid removal of CHCl3, CCl4 and TCE from water. Three types of Al-Fe alloy particles containing 10, 20 and 58 wt% of Fe (termed as Al-Fe10, Al-Fe20 and Al-Fe58) were prepared and characterized by electrochemical polarization, X-ray diffraction and energy dispersive spectrometer...
August 18, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28820012/effect-of-rotational-prosthetic-alignment-variation-on-tibiofemoral-contact-pressure-distribution-and-joint-kinematics-in-total-knee-replacement
#14
Xin Xie, Roy Rusly, John D DesJardins, Frank Voss, Kim Chillag, Martine LaBerge
In total knee replacement surgery, implant alignment is one of the most important criteria for successful long-term clinical outcome. During total knee replacement implantation, femoral and tibial alignment are determined through appropriate bone resections, which could vary based on patient anatomy, implant design and surgical technique and further influence loading conditions and clinical outcomes. The current research focused on three critical alignment parameters for total knee replacement insertion: femoral component internal/external (I/E) rotation, varus-valgus tibiofemoral angulation and posterior tibial slope...
August 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28819782/the-effects-of-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-nsaid-on-cox1-and-cox2-activities-and-gene-expression-in-ankylosing-spondylitis-patients-and-the-murine-monocyte-macrophage-j774-cell-line
#15
Fahimeh Jafarnezhad-Ansariha, Mir Saeed Yekaninejad, Ahmad-Reza Jamshidi, Reza Mansouri, Mahdi Vojdanian, Mahdi Mahmoudi, Mohammad Javad Fattahi, Seyed Naser Hashemi, Bernd H A Rehm, Hidenori Matsuo, Emanuela Esposito, Salvatore Cuzzocrea, Abbas Mirshafiey
Ankylosing spondylitis (AS) is a debilitating chronic inflammatory disease with genetic predisposition, which is characterized by the involvement of spine and sacroiliac joints. Due to the relatively unsuccessful treatments, we designed β-D-mannuronic (M2000) with the beneficial effects in various experimental models as a novel non-steroidal anti-inflammatory drug (NSAID). The aims of our present study were: first, to compare the therapeutic effects of M2000, as a novel designed NSAID, with naproxen and placebo in Iranian patients with AS during 12 weeks; second, to evaluate the effect of M2000 on gene expression of cyclooxygenase enzyme (COX-1/COX-2), a key enzyme in the initiation of inflammatory pathways in AS patients; and third, to assess the activity of COX-1 and COX-2 enzymes in the presence/absence of M2000 at the different doses in the murine macrophage, J774 cell line...
August 17, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28819670/mimicking-wettability-alterations-using-temperature-gradients-for-water-nanodroplets
#16
Chirodeep Bakli, Sree Hari P D, Suman Chakraborty
A sessile droplet or a film usually moves from hotter regions to colder regions, due to variations in interfacial tension. This, known as the so-called Marangoni effect, is true for most pure liquids like water for which the surface tension decreases with an increase in temperature. In stark contrast to this existing understanding, we bring forth the coupled effect of wettability and temperature gradients on the dynamics of the three-phase contact line. By simultaneously tracking the dynamic evolution of the three-phase contact line due to the evaporation and diffusion of molecules through molecular dynamics simulations, we explore the coterminous effects of the change of surface tension coefficients and wetting parameters with temperature on sessile droplets residing on surfaces with different wettabilities...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28819262/three-dimensional-imaging-of-vortex-structure-in-a-ferroelectric-nanoparticle-driven-by-an-electric-field
#17
D Karpov, Z Liu, T Dos Santos Rolo, R Harder, P V Balachandran, D Xue, T Lookman, E Fohtung
Topological defects of spontaneous polarization are extensively studied as templates for unique physical phenomena and in the design of reconfigurable electronic devices. Experimental investigations of the complex topologies of polarization have been limited to surface phenomena, which has restricted the probing of the dynamic volumetric domain morphology in operando. Here, we utilize Bragg coherent diffractive imaging of a single BaTiO3 nanoparticle in a composite polymer/ferroelectric capacitor to study the behavior of a three-dimensional vortex formed due to competing interactions involving ferroelectric domains...
August 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28819128/porous-polystyrene-monoliths-and-microparticles-prepared-from-core-cross-linked-star-ccs-polymers-stabilized-emulsions
#18
Qijing Chen, Ting Shi, Fei Han, Zihan Li, Chao Lin, Peng Zhao
A hydrophobic CCS polymer of poly(benzyl methacrylate) (PBzMA) was prepared in toluene by reversible addition-fragmentation chain transfer (RAFT)-mediated dispersion polymerization. The CCS polymer, with poly(benzyl methacrylate) as the arm and crosslinked N, N'-bis(acryloyl)cystamine (BAC) as the core, was confirmed by characterization with gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR) spectroscopy. Three kinds of oils (toluene, anisole and styrene) were chosen to study the emulsification properties of PBzMA CCS polymer...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818803/polymorphic-characterization-and-bioavailability-of-20-r-25-methoxyl-dammarane-3%C3%AE-12%C3%AE-20-triol-a-novel-dammarane-triterpenoid-saponin-as-anticancer-agents
#19
Meng Ding, Lei Xu, Yumeng Zhang, Yuqing Zhao
This research, for the first time, obtained and reported three novel Form I, Form II, and Form III of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol polymorphs, which were distinguished by PXRD, IR, DSC, and SEM. This study firstly exploited a rapid and feasible UHPLC-ESI-MS/MS method to determine plasma levels of 20(R)-25-OCH3-PPD within 4.5min. The composition of mobile phase was acetonitrile and 5mM ammonium acetate water (85:15, v/v) at a flow rate of 0.2mL/min on the BEH C18 Column (2.1mm×50mm, 1.7μm)...
August 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28818802/development-and-validation-of-a-gc-ms-method-for-the-determination-of-hydroxyzine-and-its-active-metabolite-cetirizine-in-whole-blood
#20
Maria Katselou, Sotiris Athanaselis, Panagiota Nikolaou, Artemisia Dona, Chara Spiliopoulou, Ioannis Papoutsis
A simple, rapid, sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of hydroxyzine and cetirizine in whole blood. Solid-phase extraction procedure using Bond Elut LRC Certify II columns was used for the isolation of hydroxyzine and cetirizine from 1mL whole blood followed by derivatization with a mixture of acetic anhydride:n-propanol (1:1, v/v). Limits of detection and quantification were 1.50 and 5.00ng/mL, respectively. The assay was linear within the concentration range of 5...
August 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
keyword
keyword
39863
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"