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https://www.readbyqxmd.com/read/29040974/an-intergroup-randomized-phase-ii-study-of-bevacizumab-or-cetuximab-in-combination-with-gemcitabine-and-in-combination-with-chemoradiation-in-patients-with-resected-pancreatic-carcinoma-a-trial-of-the-ecog-acrin-cancer-research-group-e2204
#1
Jordan D Berlin, Yang Feng, Paul Catalano, James L Abbruzzese, Philip A Philip, Robert R McWilliams, Andrew M Lowy, Al B Benson Iii, A William Blackstock
OBJECTIVES: Evaluate toxicity of two treatment arms, A (cetuximab) and B (bevacizumab), when combined with gemcitabine, and chemoradiation in patients with completely resected pancreatic carcinoma. Secondary objectives included overall survival (OS) and disease-free survival (DFS). METHODS: Patients with R0/R1 resection were randomized 1:1 to cetuximab or bevacizumab administered in combination with gemcitabine for two treatment cycles. Next three cycles included concurrent cetuximab/bevacizumab plus chemoradiation, followed by one cycle of cetuximab/bevacizumab...
October 18, 2017: Oncology
https://www.readbyqxmd.com/read/29040937/a-sensitive-hplc-ms-method-for-simultaneous-determination-of-thirteen-components-in-rat-plasma-and-its-application-to-pharmacokinetic-study-of-tanreqing-injection
#2
Su-Xiang Feng, Xian-He Li, Meng-Meng Wang, Rui Hao, Meng-Meng Li, Lei Zhang, Zhe Wang
A rapid, sensitive and selective method based on high-performance liquid chromatography coupled with Q-Exactive mass spectrometry was developed and validated for simultaneous quantification of thirteen components in rat plasma, including chlorogenic acid, 5-caffeoylquinic acid, 4-caffeoylquinic acid, luteoloside, isochlorogenic acid A, B and C, scutellarin, baicalin, wogonin, baicalein, phillyrin and forsythoside A. After precipitating proteins from the plasma samples with methanol, chromatographic separation of the thirteen components was achieved by using an XBridge™ C18 column (2...
October 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29040834/effect-of-oil-structure-on-cyclodextrin-based-pickering-emulsions-for-bupivacaine-topical-application
#3
Jiun-Wen Hu, Mei-Wen Yen, Ae-June Wang, I-Ming Chu
Cyclodextrins (CDs) coupled with oils forms an insoluble inclusion complex that is able to adsorb to the interface between oils and aqueous phases; it thereby stabilizes Pickering emulsions. Three types of oils (triglyceride, linear chain oil, and ring-structured oil) were chosen to work with CDs to prepare bupivacaine (BPC)-encapsulated Pickering emulsions. We also investigated the relationship between oils and CDs; as well as their influences on stability, drug-releasing capability and skin permeability. Particle sizes and microstructures were determined by dynamic light scattering and scanning electron microscopy, respectively...
October 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29039943/synthesis-and-structural-electrical-and-magnetic-properties-of-new-iron-aluminum-alluaudite-phases-%C3%AE-na2ni2m-po4-3-m-fe-and-al
#4
Douha Harbaoui, Moustafa M S Sanad, Cécile Rossignol, El Kebir Hlil, Noureddine Amdouni, Saïd Obbade
Herein we report the studies of different physical properties (structural, magnetic, thermal, morphologic, electrical, and electrochemical) of two new allotropic β-Na2Ni2M(PO4)3 (NNMP) phosphates, with M = Fe and Al. Pure orthorhombic single-phase powders were prepared under air, using an autocombustion synthesis method. They crystallize in the orthorhombic Imma space group with similar unit cell parameters [a = 10.1592(2), b = 13.0321(3), c = 6.4864(2) Å] and [a = 10.3993(1), b = 13.1966(1), c = 6.4955(1) Å] for β-Na2Ni2M(PO4)3 (NNAP) and β-Na2Ni2Fe(PO4)3 (NNFP), respectively...
October 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29037017/preoperative-chemoradiotherapy-versus-postoperative-chemoradiotherapy-for-stage-ii-iii-resectable-rectal-cancer-a-meta-analysis-of-randomized-controlled-trials
#5
Jin Ho Song, Jae Uk Jeong, Jong Hoon Lee, Sung Hwan Kim, Hyeon Min Cho, Jun Won Um, Hong Seok Jang
PURPOSE: Whether preoperative chemoradiotherapy (CRT) is better than postoperative CRT in oncologic outcome and toxicity is contentious in prospective randomized clinical trials. We systematically analyze and compare the treatment result, toxicity, and sphincter preservation rate between preoperative CRT and postoperative CRT in stage II-III rectal cancer. MATERIALS AND METHODS: We searched Medline, Embase, and Cochrane Library from 1990 to 2014 for relevant trials...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29035942/phase-ii-randomized-sham-controlled-study-of-renal-denervation-for-individuals-with-uncontrolled-hypertension-wave-iv
#6
Roland E Schmieder, Christian Ott, Stefan W Toennes, Peter Bramlage, Michael Gertner, Omar Dawood, Peter Baumgart, Benjamin O'Brien, Indranil Dasgupta, Georg Nickenig, John Ormiston, Manish Saxena, Andrew S P Sharp, Horst Sievert, Jindrich Spinar, Zdenek Starek, Joachim Weil, Ulrich Wenzel, Adam Witkowski, Melvin D Lobo
OBJECTIVES: The aim of this double-blind, randomized, sham-controlled study was to verify the blood pressure (BP)-lowering efficacy of externally delivered focused ultrasound for renal denervation (RDN). BACKGROUND: Nonrandomized, first proof-of-concept study and experimental evidence suggested that noninvasive techniques of RDN emerged as an alternative approach of RDN to invasive technologies. METHODS: WAVE IV, an international, randomized (1 : 1) sham-controlled, double-blind prospective clinical study, was prematurely stopped...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035712/process-integration-for-material-synthesis-from-a-deactivated-catalyst-studies-on-the-interaction-of-metal-ions-between-two-immiscible-phases
#7
D Mishra, K K Sahu, A Agrawal
Present investigation deals with the treatment of deactivated Co-Mn bromide catalyst for the recovery of Co and Mn as Co metal powder and chemical manganese dioxide by an integrated process comprising of a selective metal ion transfer from an aqueous solution containing a mixture of metal ions with a saponified solution of di-2ethyl-hexyl phosphoric acid, followed by selective scrubbing and metal stripping. The pure metal solutions so obtained were subjected to precipitation and hydrothermal treatment to obtain a desired material...
October 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29035643/role-of-bone-modifying-agents-in-metastatic-breast-cancer-an-american-society-of-clinical-oncology-cancer-care-ontario-focused-guideline-update
#8
Catherine Van Poznak, Mark R Somerfield, William E Barlow, J Sybil Biermann, Linda D Bosserman, Mark J Clemons, Sukhbinder K Dhesy-Thind, Melissa S Dillmon, Andrea Eisen, Elizabeth S Frank, Reshma Jagsi, Rachel Jimenez, Richard L Theriault, Theodore A Vandenberg, Gary C Yee, Beverly Moy
Purpose To update, in collaboration with Cancer Care Ontario (CCO), key recommendations of the American Society of Clinical Oncology (ASCO) guideline on the role of bone-modifying agents (BMAs) in metastatic breast cancer. This focused update addressed the new data on intervals between dosing and the role of BMAs in control of bone pain. Methods A joint ASCO-CCO Update Committee conducted targeted systematic literature reviews to identify relevant studies. Results The Update Committee reviewed three phase III noninferiority trials of dosing intervals, one systematic review and meta-analysis of studies of de-escalation of BMAs, and two randomized trials of BMAs in control of pain secondary to bone metastases...
October 16, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29035543/speciated-monitoring-of-gas-phase-organic-peroxy-radicals-by-chemical-ionization-mass-spectrometry-cross-reactions-between-ch3o2-ch3-co-o2-ch3-3co2-and-c-c6h11o2
#9
Barbara Noziere, David R Hanson
Organic peroxy radicals ("RO2", with R organic) are key intermediates in most oxygen-rich systems where organic compounds are oxidized (natural environment, flames, combustion engines, living organisms…). But, until recently, techniques able to monitor simultaneously and distinguish between RO2 species ("speciated" detection) have been scarce, which has limited the understanding of complex systems containing these radicals. Mass Spectrometry using proton transfer ionization has been shown previously to detect individual gas-phase RO2 separately...
October 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29035275/polynomial-description-of-inhomogeneous-topological-superconducting-wires
#10
Marcos Pérez, Gerardo Martinez
We present universal features of the topological invariant for {\it p}-wave superconducting wires after the inclusion of spatial inhomogeneities. Three classes of distributed potentials are studied, a single-defect, a commensurate and an incommensurate model, using periodic site modulations. An analytic polynomial description is achieved by splitting the topological invariant into two parts, one part depends on the chemical potential and the other does not. For the homogeneous case, an elliptical region is found where the topological invariant oscillates...
October 16, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29035244/cryopreservation-of-leishmania-species-in-manisa-province
#11
İbrahim Çavuş, Fulya Ocak, Tuğba Kaya, Ahmet Özbilgin
OBJECTIVE: It was aimed to assess the success of the cryopreservation process which is carried out in order to preserve the genetic material and the virulence of the Leishmania species that are an important health problem in our region. METHODS: Leishmania tropica, L. infantum, L. major, and L. donovani strains in Novy-MacNeal-Nicolle (NNN) medium in MCBU were used. Promastigotes cultured in the NNN medium were transferred to RPMI 1640 medium; promastigotes in the logarithmic phase were washed three times with PBS, and 15% dimethylsulfoxide (DMSO) was added...
September 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29035060/a-computational-study-investigating-the-energetics-and-kinetics-of-the-hnco-ch3-2nh-reaction-catalyzed-by-a-single-water-molecule
#12
Arathala Parandaman, Chanin B Tangtartharakul, Manoj Kumar, Joseph S Francisco, Amitabha Sinha
High level ab initio calculations are used to explore the energetics and kinetics for the formation of 1,1-dimethyl urea via the reaction of isocyanic acid (HNCO) with dimethyl amine (DMA) catalyzed by a single water molecule. Compared to the uncatalyzed HNCO+DMA reaction, the presence of a water molecule lowers the reaction barrier, defined here as the energy difference between the separated HNCO+DMA+H2O reactants and the transition state (TS), by ~23 kcal/mol. In addition to the HNCO+DMA+H2O reaction, the energetics of the analogous reactions involving respectively ammonia and methyl amine were also investigated...
October 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29034423/effect-and-mechanism-of-microwave-activated-ultraviolet-advanced-oxidation-technology-for-adsorbent-regeneration
#13
Yanlong Sun, Tong Zheng, Guangshan Zhang, Yunli Zheng, Peng Wang
To decrease the secondary pollution of volatile organic compounds (VOCs) during adsorbent regeneration by microwave, electrodeless lamp was added in the microwave field to oxidize VOCs in the gas phase. Ultraviolet has a significant improvement on mineralization of VOCs generated from adsorbate during adsorbent regeneration. However, the mechanism and main influence factors on the degradation of VOCs are not clear. The effect of microwave power, regeneration time, airflow rate, and humidity content on the mineralization of adsorbed tetracycline during adsorbent regeneration was studied...
October 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29033985/the-effects-of-acupressure-on-pain-severity-in-female-nurses-with-chronic-low-back-pain
#14
Maryam Movahedi, Somayeh Ghafari, Fateme Nazari, Mahboubeh Valiani
BACKGROUND: Low back pain causes physical and psychological impacts among nurses. This study aimed to investigate the effects of acupressure on the severity of pain in chronic low back pain in female nurses. MATERIALS AND METHODS: This study is a single-blinded randomized clinical trial conducted among 50 nurses suffering from chronic low back pain. After simple sampling, participants were randomly assigned into acupressure and sham groups using lottery method (25 patients in each group)...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29033919/adaptation-of-methanogenic-inocula-to-anaerobic-digestion-of-maize-silage
#15
Martyna Wojcieszak, Adam Pyzik, Krzysztof Poszytek, Pawel S Krawczyk, Adam Sobczak, Leszek Lipinski, Otton Roubinek, Jacek Palige, Aleksandra Sklodowska, Lukasz Drewniak
A well-balanced microbial consortium is crucial for efficient biogas production. In turn, one of a major factor that influence on the structure of anaerobic digestion (AD) consortium is a source of microorganisms which are used as an inoculum. This study evaluated the influence of inoculum sources (with various origin) on adaptation of a biogas community and the efficiency of the biomethanization of maize silage. As initial inocula for AD of maize silage the samples from: (i) an agricultural biogas plant (ABP) which utilizes maize silage as a main substrate, (ii) cattle slurry (CS), which contain elevated levels of lignocelluloses materials, and (iii) raw sewage sludge (RSS) with low content of plant origin materials were used...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033896/the-influence-of-a-kdt501-a-novel-isohumulone-on-adipocyte-function-in-humans
#16
Brian S Finlin, Beibei Zhu, Bernard P Kok, Cristina Godio, Philip M Westgate, Neile Grayson, Robert Sims, Jeffrey S Bland, Enrique Saez, Philip A Kern
OBJECTIVE: In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whether KDT501 increased adiponectin secretion from subcutaneous white adipose tissue (SC WAT) and the underlying mechanism(s). METHODS: Nine obese participants with either prediabetes or with normal glucose tolerance plus three features of metabolic syndrome were part of the study...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29033879/nasally-administered-oxytocin-has-limited-effects-on-owner-directed-attachment-behavior-in-pet-dogs-canis-lupus-familiaris
#17
Lauren E Thielke, Giovanna Rosenlicht, Sarina R Saturn, Monique A R Udell
The present study explored the effects of intranasal oxytocin, a naturally occurring hormone, on the behavior of pet dogs during an attachment test. Each dog participated in two testing sessions. On one visit saline was administered nasally, and on another, oxytocin was administered nasally. For half of the dogs (n = 20), solutions were administered with a Mucosal Atomization Device (MAD) and for half of the dogs (n = 20), solutions were administered using a nasal spray bottle. Condition order was counterbalanced and a double-blind methodology was employed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29033465/parental-modeling-and-deidentification-in-romantic-relationships-among-mexican-origin-youth
#18
Sally I-Chun Kuo, Lorey A Wheeler, Kimberly A Updegraff, Susan M McHale, Adriana J Umaña-Taylor, Norma J Perez-Brena
This study investigated youth's modeling of and de-identification from parents in romantic relationships, using two phases of data from adolescent siblings, mothers, and fathers in 246 Mexican-origin families. Each parent reported his/her marital satisfaction and conflict, and youth reported on parent-adolescent warmth and conflict at Time 1. Youth's reports of modeling of and de-identification from their mothers and fathers and three romantic relationship outcomes were assessed at Time 2. Findings revealed that higher parental marital satisfaction, lower marital conflict, and higher warmth and lower conflict in parent-adolescent relationships were associated with more modeling and less de-identification from parents...
October 2017: Journal of Marriage and the Family
https://www.readbyqxmd.com/read/29033099/custirsen-ogx-011-combined-with-cabazitaxel-and-prednisone-versus-cabazitaxel-and-prednisone-alone-in-patients-with-metastatic-castration-resistant-prostate-cancer-previously-treated-with-docetaxel-affinity-a-randomised-open-label-international-phase-3-trial
#19
Tomasz M Beer, Sebastien J Hotte, Fred Saad, Boris Alekseev, Vsevolod Matveev, Aude Fléchon, Gwenaelle Gravis, Florence Joly, Kim N Chi, Zafar Malik, Brent Blumenstein, Patricia S Stewart, Cindy A Jacobs, Karim Fizazi
BACKGROUND: Docetaxel and cabazitaxel improve overall survival compared with mitoxantrone in patients with metastatic castration-resistant prostate cancer. Custirsen (OGX011) is a second generation highly specific antisense oligonucleotide that inhibits the production of clusterin, an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance. We aimed to assess whether custirsen in combination with cabazitaxel and prednisone increases overall survival in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel...
October 9, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29032956/evaluation-of-surface-treatments-of-monolithic-zirconia-in-different-sintering-stages
#20
Kamal Ebeid, Sebastian Wille, Tarek Salah, Marwa Wahsh, Maged Zohdy, Matthias Kern
PURPOSE: This study evaluated the effect of surface treatment of zirconia in pre-sintered and post-sintered stages on its surface roughness, phase transformation, and biaxial flexural strength (BFS). METHODS: Zirconia ceramic discs (n=40) having a final dimensions of 12mm diameter and 1.2mm thickness were milled then divided into three main groups according to the type of surface treatment performed (Group 1 (n=16); air-abrasion using Al2O3 particles, Group 2 (n=16); silica coating using Rocatec soft, and Group 3 (n=8); a control group receiving no surface treatment)...
October 9, 2017: Journal of Prosthodontic Research
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