keyword
MENU ▼
Read by QxMD icon Read
search

Yale goal

keyword
https://www.readbyqxmd.com/read/27869250/preliminary-analyses-of-psychometric-characteristics-of-the-polish-version-of-the-obsessive-compulsive-inventory-revised-oci-r-in-a-non-clinical-sample
#1
Justyna Mojsa-Kaja, Krystyna Golonka, Magda Gawłowska
OBJECTIVES: Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder that affects 1-2% of the adult population. People with OCD are more likely to report impaired social and occupational functioning. Although effective treatments of the OCD exist, many sufferers from this disorder are continuously misdiagnosed. Therefore, improving the assessment of the OCD remains an important area of scientific research. The main goal of the study is the initial verification of psychometric properties in the Polish version of the Obsessive-Compulsive Inventory-Revised (OCI-R) in a college student sample...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/27858564/preparing-for-value-based-payment-a-stepwise-approach-for-cancer-centers
#2
Kerin B Adelson, Salimah Velji, Kavita Patel, Basit Chaudhry, Catherine Lyons, Rogerio Lilenbaum
Most cancer centers are ill-equipped to pursue value-based payment (VBP) because of limited information on their population's cost of care. Herein, we outline the stepwise approach used by Smilow Cancer Hospital at Yale-New Haven in our pursuit of better value care. First, we addressed institutional barriers. A move toward value required demonstration to Yale-New Haven Health System leadership that OCM would improve patient care, fund new infrastructure, and provide the opportunity to gain experience with VBP without a major threat to the financial stability of the health system...
October 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27798125/reconnecting-eye-to-brain
#3
Michael C Crair, Carol A Mason
Although much is known about the regenerative capacity of retinal ganglion cells, very significant barriers remain in our ability to restore visual function following traumatic injury or disease-induced degeneration. Here we summarize our current understanding of the factors regulating axon guidance and target engagement in regenerating axons, and review the state of the field of neural regeneration, focusing on the visual system and highlighting studies using other model systems that can inform analysis of visual system regeneration...
October 19, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27695647/chemotherapy-for-elderly-ovarian-cancer-patients
#4
Sivraj Muralikrishnan, Christos Hatzis, Andrea Katz, Alessandro Santin, Peter E Schwartz, Maysa M Abu-Khalaf
OBJECTIVE: Ovarian cancer is the most lethal cancer involving the female pelvic reproductive system. Its incidence increases with age and with an aging population, its prevalence should also increase. The goal of our retrospective study is to report our experience in treating women over 65 years of age, with a diagnosis of primary ovarian cancer, using standard intravenous chemotherapy. METHODS: The medical records of 78 patients>65 years of age diagnosed with primary ovarian cancer at the Yale Cancer Center between 1996-2006 were retrospectively reviewed and included in our analysis...
August 2016: Gynecology & Obstetrics: Current Research
https://www.readbyqxmd.com/read/27515060/endometrial-sampling-devices-for-early-diagnosis-of-endometrial-lesions
#5
REVIEW
Jiang Du, Yaling Li, Shulan Lv, Qing Wang, Chao Sun, Xin Dong, Ming He, Qurat Ulain, Yongxing Yuan, Xiaoqian Tuo, Nasra Batchu, Qing Song, Qiling Li
PURPOSE: Endometrial carcinoma is the most common gynecologic malignancy in both developed and some developing countries. Unlike cervical cancer, for which there is routine screening, only patients symptomatic for endometrial carcinoma typically seek medical help for its diagnosis and treatment. Dilatation and curettage (D&C) has been the standard procedure for evaluating suspicious endometrial lesions. The discomfort and injury caused by the D&C procedure, however, restrict its use as a screening method for early diagnosis of endometrial lesions...
December 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27507113/hypochloremia-and-diuretic-resistance-in-heart-failure-mechanistic-insights
#6
Jennifer S Hanberg, Veena Rao, Jozine M Ter Maaten, Olga Laur, Meredith A Brisco, F Perry Wilson, Justin L Grodin, Mahlet Assefa, J Samuel Broughton, Noah J Planavsky, Tariq Ahmad, Lavanya Bellumkonda, W H Wilson Tang, Chirag R Parikh, Jeffrey M Testani
BACKGROUND: Recent epidemiological studies have implicated chloride, rather than sodium, as the driver of poor survival previously attributed to hyponatremia in heart failure. Accumulating basic science evidence has identified chloride as a critical factor in renal salt sensing. Our goal was to probe the physiology bridging this basic and epidemiological literature. METHODS AND RESULTS: Two heart failure cohorts were included: (1) observational: patients receiving loop diuretics at the Yale Transitional Care Center (N=162) and (2) interventional pilot: stable outpatients receiving ≥80 mg furosemide equivalents were studied before and after 3 days of 115 mmol/d supplemental lysine chloride (N=10)...
August 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27405296/effects-of-extended-release-niacin-laropiprant-on-correlations-between-apolipoprotein-b-ldl-cholesterol-and-non-hdl-cholesterol-in-patients-with-type-2-diabetes
#7
Eliot A Brinton, Joseph Triscari, Philippe Brudi, Erluo Chen, Amy O Johnson-Levonas, Christine McCrary Sisk, Rae Ann Ruck, Alexandra A MacLean, Darbie Maccubbin, Yale B Mitchel
BACKGROUND: LDL-C, non-HDL-C and ApoB levels are inter-correlated and all predict risk of atherosclerotic cardiovascular disease (ASCVD) in patients with type 2 diabetes mellitus (T2DM) and/or high TG. These levels are lowered by extended-release niacin (ERN), and changes in the ratios of these levels may affect ASCVD risk. This analysis examined the effects of extended-release niacin/laropiprant (ERN/LRPT) on the relationships between apoB:LDL-C and apoB:non-HDL-C in patients with T2DM...
July 12, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27379199/frequent-episodes-of-detectable-viremia-in-hiv-treatment-experienced-children-is-associated-with-a-decline-in-cd4-t-cells-over-time
#8
Elijah Paintsil, Ryan Martin, Ariel Goldenthal, Shreya Bhandari, Warren Andiman, Musie Ghebremichael
BACKGROUND: The clinical consequences of the magnitude and the duration of detectable viremia in HIV-infected children have not been well characterized. We examined the predictors and immunologic consequences over time of frequent episodes of detectable viremia in HIV-infected children followed at Yale-New Haven Hospital. METHODS: We analyzed the CD4+ T-cell and HIV viral load over a 19-year period (1996 to 2013) of 104 HIV-infected children enrolled in the Yale Prospective Longitudinal Pediatric HIV Cohort...
April 2016: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/27298406/t-dm1-activity-in-metastatic-human-epidermal-growth-factor-receptor-2-positive-breast-cancers-that-received-prior-therapy-with-trastuzumab-and-pertuzumab
#9
Hannah Dzimitrowicz, Michael Berger, Craig Vargo, Annette Hood, Osama Abdelghany, Akshara Singareeka Raghavendra, Debu Tripathy, Vicente Valero, Christos Hatzis, Lajos Pusztai, Rashmi Murthy
PURPOSE: Ado-trastuzumab emtansine (T-DM1) is currently approved for treatment in patients with human epidermal growth factor receptor 2 (HER2)-positive, metastatic breast cancer (MBC) who previously received trastuzumab and a taxane. However, there are no data on the activity of T-DM1 in patients who received prior pertuzumab, which is now included as standard first-line therapy. The goal of this study was to assess the efficacy of T-DM1 in routine clinical practice in a contemporary patient population that received both prior trastuzumab and pertuzumab...
June 13, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27292366/promoting-convergence-the-integrated-graduate-program-in-physical-and-engineering-biology-at-yale-university-a-new-model-for-graduate-education
#10
Dorottya B Noble, Simon G J Mochrie, Corey S O'Hern, Thomas D Pollard, Lynne Regan
In 2008, we established the Integrated Graduate Program in Physical and Engineering Biology (IGPPEB) at Yale University. Our goal was to create a comprehensive graduate program to train a new generation of scientists who possess a sophisticated understanding of biology and who are capable of applying physical and quantitative methodologies to solve biological problems. Here we describe the framework of the training program, report on its effectiveness, and also share the insights we gained during its development and implementation...
November 12, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/26885640/multiscale-modeling-in-the-clinic-drug-design-and-development
#11
Colleen E Clancy, Gary An, William R Cannon, Yaling Liu, Elebeoba E May, Peter Ortoleva, Aleksander S Popel, James P Sluka, Jing Su, Paolo Vicini, Xiaobo Zhou, David M Eckmann
A wide range of length and time scales are relevant to pharmacology, especially in drug development, drug design and drug delivery. Therefore, multiscale computational modeling and simulation methods and paradigms that advance the linkage of phenomena occurring at these multiple scales have become increasingly important. Multiscale approaches present in silico opportunities to advance laboratory research to bedside clinical applications in pharmaceuticals research. This is achievable through the capability of modeling to reveal phenomena occurring across multiple spatial and temporal scales, which are not otherwise readily accessible to experimentation...
September 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/26774939/the-efficacy-of-residents-as-teachers-in-an-ophthalmology-module
#12
Peter A Ryg, Janet P Hafler, Susan H Forster
OBJECTIVE: Resident physicians have reported spending upward of 25% of their time teaching fellow residents and medical students. Until relatively recently, there have not been formal requirements in residency programs to learn teaching skills. The first goal of this study was to develop a novel residents-as-teachers training program to educate Ophthalmology residents on facilitating group learning and emphasizing critical-thinking skills. The second goal was to educate residents on how to teach clinical reasoning skills...
March 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/26575172/in-vivo-regeneration-of-renal-vessels-post-whole-decellularized-kidneys-transplantation
#13
JianSe Zhang, ZhiBin Wang, KeZhi Lin, YaLing Yu, LiNa Zhao, TingGang Chu, LiZhi Wu, Ali Alkhawaji, MiaoZhong Li, YingKuan Shao, Ting Li, XinFa Lou, ShiXin Chen, MaoLin Tang, Jin Mei
Nearly 50 million patients in China live with end-stage renal disease (ESRD), and only about 4000 patients may receive kidney transplantation. The purpose of this study was to investigate regeneration of renal vessels post whole decellularized kidneys transplantation in vivo. We decellularized kidneys of donor rats by perfusing a detergent through the abdominal aorta, yielding feasible extracellular matrix, confirmed for acellularity before transplantation. Based on the concept of using the body as a bioreactor, we orthotopically transplanted the kidney and ureter scaffolds in recipient rats, and found the regeneration of vessels including artery and vein in the renal sinus following a spontaneous recanalization...
December 1, 2015: Oncotarget
https://www.readbyqxmd.com/read/26530196/-effects-of-the-bright-bodies-program-in-chilean-obese-children
#14
Paulina Bustos, Jorge Orias, Katia Sáez, Marcela Maldonado, Liliana Cuadra, Sylvia Asenjo
BACKGROUND: Yale University's Bright Bodies Program consists on a lifestyle intervention, in areas such as nutrition and exercise, while focusing on behavior modification and family support. AIM: To evaluate the impact of the Program in Chilean children and adolescents with obesity who participated in the Program during 8 months. MATERIAL AND METHODS: The weight management Program was carried out during 8 months and consisted in weekly sessions directed by dietitians or psychologists and exercise sessions twice per week in charge of physical education teachers...
September 2015: Revista Médica de Chile
https://www.readbyqxmd.com/read/26427131/design-of-analytical-run-length-for-clinical-chemistry-analytes
#15
COMPARATIVE STUDY
Litao Hu, Wei Wang, Yaling Xiao, Zhiguo Wang
BACKGROUND: The expected number of unacceptable patient results E (Nu) can be set as a patient-based quality goal. Analytical run length can be designed to limit E (Nu) < 1. METHODS: The new internal quality control (IQC) strategy and length of analytical run for each analyte was applied to routine IQC paralleled with the way before redesign. IQC charts were produced by QC test results to analyze and compare the performance of out-of-control error detection. RESULTS: Optimal analytical run lengths designed by the quality control computer software QCCS 2008 were 39 for albumin, 61 for cholesterol, 900 for triglycerides, 112 for aspartate aminotransferase, 279 for lactate dehydrogenase, 267 for alcaline phospatase, 363 for total bilirubin, 151 for ceatinine, 230 for uric acid, 46 for phosphorus PHOS, 158 for carbon dioxide, and 580 for glucose...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26343478/sensory-phenomena-related-to-tics-obsessive-compulsive-symptoms-and-global-functioning-in-tourette-syndrome
#16
Yukiko Kano, Natsumi Matsuda, Maiko Nonaka, Miyuki Fujio, Hitoshi Kuwabara, Toshiaki Kono
OBJECTIVES: Sensory phenomena, including premonitory urges, are experienced by patients with Tourette syndrome (TS) and obsessive-compulsive disorder (OCD). The goal of the present study was to investigate such phenomena related to tics, obsessive-compulsive symptoms (OCS), and global functioning in Japanese patients with TS. METHODS: Forty-one patients with TS were assessed using the University of São Paulo Sensory Phenomena Scale (USP-SPS), the Premonitory Urge for Tics Scale (PUTS), the Yale Global Tic Severity Scale (YGTSS), the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), and the Global Assessment of Functioning (GAF) Scale...
October 2015: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/26278470/inference-based-approach-versus-cognitive-behavioral-therapy-in-the-treatment-of-obsessive-compulsive-disorder-with-poor-insight-a-24-session-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Henny A Visser, Harold van Megen, Patricia van Oppen, Merijn Eikelenboom, Adriaan W Hoogendorn, Maarten Kaarsemaker, Anton J van Balkom
OBJECTIVE: Obsessive-compulsive disorder (OCD) with poor insight has severe consequences for patients; nonetheless, no randomized controlled trial has ever been performed to evaluate the effectiveness of any treatment specifically for poor-insight OCD. A new psychotherapy for OCD, the inference-based approach (IBA), targets insight in OCD by strengthening normal sensory-driven reality testing. The goal of the present study is to compare the effectiveness of this new treatment to the effectiveness of cognitive behavior therapy (CBT) for patients with OCD with poor insight...
2015: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/26267366/an-evaluation-of-the-italian-version-of-the-yale-food-addiction-scale-in-obese-adult-inpatients-engaged-in-a-1-month-weight-loss-treatment
#18
Martina Ceccarini, Gian Mauro Manzoni, Gianluca Castelnuovo, Enrico Molinari
Addiction is a compulsive need for and use of a specific substance leading to a habit, tolerance, and psychophysiological symptoms. Excessive food consumption is similar to that of substance addiction. Some individuals who have trouble losing weight display addictive eating symptoms. To investigate food addiction in a sample of obese adults referred to hospital for a 1-month-weight-loss treatment. The Italian version of the Yale Food Addiction Scale (YFAS-16) was used as a screening tool in 88 obese inpatients...
November 2015: Journal of Medicinal Food
https://www.readbyqxmd.com/read/26015273/a-statistical-framework-to-predict-functional-non-coding-regions-in-the-human-genome-through-integrated-analysis-of-annotation-data
#19
Qiongshi Lu, Yiming Hu, Jiehuan Sun, Yuwei Cheng, Kei-Hoi Cheung, Hongyu Zhao
Identifying functional regions in the human genome is a major goal in human genetics. Great efforts have been made to functionally annotate the human genome either through computational predictions, such as genomic conservation, or high-throughput experiments, such as the ENCODE project. These efforts have resulted in a rich collection of functional annotation data of diverse types that need to be jointly analyzed for integrated interpretation and annotation. Here we present GenoCanyon, a whole-genome annotation method that performs unsupervised statistical learning using 22 computational and experimental annotations thereby inferring the functional potential of each position in the human genome...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25678281/safety-and-efficacy-of-a-novel-abluminal-groove-filled-biodegradable-polymer-sirolimus-eluting-stent-for-the-treatment-of-de-novo-coronary-lesions-two-year-results-from-a-prospective-patient-level-pooled-analysis-of-target-trials
#20
Zhan Gao, Ruiyan Zhang, Bo Xu, Yuejin Yang, Changsheng Ma, Hui Li, Shaoliang Chen, Yaling Han, Zuyi Yuan, Alexandra J Lansky, Changdong Guan, Martin B Leon, Runlin Gao
OBJECTIVES: We aimed to evaluate the safety and effectiveness of the novel abluminal groove-filled biodegradable polymer-coated sirolimus-eluting FIREHAWK stent (MicroPort Medical, Shanghai, China) in a large cohort of patients. BACKGROUND: Trials on the FIREHAWK stent allowing targeted sirolimus release were not individually powered to reliably estimate low-frequency safety endpoints such as stent thrombosis (ST) or to examine long-term safety and efficacy. Additionally, the China Food and Drug Administration requires an objective performance criterion (OPC) study for new drug-eluting stents...
March 2015: Catheterization and Cardiovascular Interventions
keyword
keyword
39861
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"