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R S Duman

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https://www.readbyqxmd.com/read/28886321/relationship-between-mcp1-2518a-g-gene-variants-and-ovarian-cancer-in-turkish-population
#1
R Attar, S G Yilmaz, B Çakmakoğlu, S Duman, G Yildirim, U Görmüş, T İsbir
The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G)  in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52).There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28702685/durable-usage-of-patient-reported-outcome-measures-in-clinical-practice-to-monitor-health-related-quality-of-life-in-head-and-neck-cancer-patients
#2
S Duman-Lubberding, C F van Uden-Kraan, F Jansen, B I Witte, S E J Eerenstein, S van Weert, R de Bree, C R Leemans, I M Verdonck-de Leeuw
PURPOSE: To investigate the long-term follow-up (5 years) of implementing patient-reported outcome measures (PROMs) in clinical practice to monitor health-related quality of life (HRQOL) in head and neck cancer (HNC) patients. METHODS: A mixed method design was used. The usage rate of OncoQuest (a touch screen computer system to monitor HRQOL) and the subsequent nurse consultation was calculated among HNC patients who visited the outpatient clinic for regular follow-up, as well as differences between ever users and never users (sociodemographic and clinical characteristics)...
July 12, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28337525/phosphodiesterase-1b-pde1b-knockout-mice-are-resistant-to-forced-swim-and-tail-suspension-induced-immobility-and-show-upregulation-of-pde10a
#3
Jillian R Hufgard, Michael T Williams, Matthew R Skelton, Olivera Grubisha, Filipa M Ferreira, Helen Sanger, Mary E Wright, Tracy M Reed-Kessler, Kurt Rasmussen, Ronald S Duman, Charles V Vorhees
RATIONALE: Major depressive disorder is a leading cause of suicide and disability. Despite this, current antidepressants provide insufficient efficacy in more than 60% of patients. Most current antidepressants are presynaptic reuptake inhibitors; postsynaptic signal regulation has not received as much attention as potential treatment targets. OBJECTIVES: We examined the effects of disruption of the postsynaptic cyclic nucleotide hydrolyzing enzyme, phosphodiesterase (PDE) 1b, on depressive-like behavior and the effects on PDE1B protein in wild-type (WT) mice following stress...
June 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28297347/geometric-dose-prediction-model-for-hemithoracic-intensity-modulated-radiation-therapy-in-mesothelioma-patients-with-two-intact-lungs
#4
LiCheng Kuo, Ellen D Yorke, Vishruta A Dumane, Amanda Foster, Zhigang Zhang, James G Mechalakos, Abraham J Wu, Kenneth E Rosenzweig, Andreas Rimner
The presence of two intact lungs makes it challenging to reach a tumoricidal dose with hemithoracic pleural intensity-modulated radiation therapy (IMRT) in patients with malignant pleural mesothelioma (MPM) who underwent pleurectomy/decortications or have unresectable disease. We developed an anatomy-based model to predict attainable prescription dose before starting optimization. Fifty-six clinically delivered IMRT plans were analyzed regarding correlation of prescription dose and individual and total lung volumes, planning target volume (PTV), ipsilateral normal lung volume and ratios: contralateral/ipsilateral lung (CIVR); contralateral lung/PTV (CPVR); ipsilateral lung /PTV (IPVR); ipsilateral normal lung /total lung (INTLVR); ipsilateral normal lung/PTV (INLPVR)...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28043916/ketamine-accelerates-fear-extinction-via-mtorc1-signaling
#5
Matthew J Girgenti, Sriparna Ghosal, Dora LoPresto, Jane R Taylor, Ronald S Duman
Impaired fear extinction contributes to the persistence of post-traumatic stress disorder (PTSD), and can be utilized for the study of novel therapeutic agents. Glutamate plays an important role in the formation of traumatic memories, and in the pathophysiology and treatment of PTSD, highlighting several possible drug targets. Recent clinical studies demonstrate that infusion of ketamine, a glutamate NMDA receptor antagonist, rapidly and significantly reduces symptom severity in PTSD patients. In the present study, we examine the mechanisms underlying the actions of ketamine in a rodent model of fear conditioning, extinction, and renewal...
December 30, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27779843/steric-switching-from-photochemical-to-thermal-reaction-pathways-for-enhanced-efficiency-in-metal-mediated-nitrogen-fixation
#6
Leila M Duman, Wesley S Farrell, Peter Y Zavalij, Lawrence R Sita
Programmed manipulation of the subtle interplay of nonbonded steric interactions within a supporting ligand environment has been used for the conversion of a photochemically driven chemical cycle for group 6 metal-mediated nitrogen fixation into a thermally promoted process with increased energy efficiency and atom economy for key transformations involving N≡N bond cleavage and N-atom functionalization of coordinated N2.
November 16, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27349137/efficiency-of-beetle-dendroides-canadensis-recombinant-antifreeze-protein-for-buffalo-semen-freezability-and-fertility
#7
S Qadeer, M A Khan, Q Shahzad, A Azam, M S Ansari, B A Rakha, R Ejaz, A U Husna, J G Duman, S Akhter
Overwintering larvae of the beetle Dendroides canadensis produce potent antifreeze proteins to inhibit inoculative freezing and promote supercooling. We hypothesized that addition of Dendroides canadensis recombinant antifreeze proteins (DAFPs) in the extender will improve the quality and fertility of cryopreserved Nili-Ravi buffalo (Bubalus bubalis) sperm. The study was divided into two parts: (1) Evaluation of the effect of DAFPs on the quality of frozen-thawed buffalo bull sperm and (2) Examination of the fertilizing ability of frozen-thawed buffalo bull sperm...
October 15, 2016: Theriogenology
https://www.readbyqxmd.com/read/27346079/constance-e-lieber-theodore-r-stanley-and-the-enduring-impact-of-philanthropy-on-psychiatry-research
#8
John H Krystal, Anissa Abi-Dargham, Schahram Akbarian, Amy F T Arnsten, Deanna M Barch, Carrie E Bearden, David L Braff, E Sherwood Brown, Edward T Bullmore, William A Carlezon, Cameron S Carter, Edwin H Cook, Zafiris Jeff Daskalakis, Ralph J DiLeone, Ronald S Duman, Anthony A Grace, Ahmad R Hariri, Paul J Harrison, Noboru Hiroi, Paul J Kenny, Joel E Kleinman, Andrew D Krystal, David A Lewis, Barbara K Lipska, Stephen R Marder, Graeme F Mason, Daniel H Mathalon, Colleen A McClung, Christopher J McDougle, Andrew M McIntosh, Francis J McMahon, Károly Mirnics, Lisa M Monteggia, Rajesh Narendran, Eric J Nestler, Alexander Neumeister, Michael C O'Donovan, Dost Öngür, Carmine M Pariante, Martin P Paulus, Godfrey Pearlson, Mary L Phillips, Daniel S Pine, Diego A Pizzagalli, Mikhail V Pletnikov, J Daniel Ragland, Judith L Rapoport, Kerry J Ressler, Scott J Russo, Gerard Sanacora, Akira Sawa, Alan F Schatzberg, Yavin Shaham, Simone G Shamay-Tsoory, Pamela Sklar, Matthew W State, Murray B Stein, Stephen M Strakowski, Stephan F Taylor, Gustavo Turecki, Bruce I Turetsky, Myrna M Weissman, Venetia Zachariou, Carlos A Zarate, Jon-Kar Zubieta
No abstract text is available yet for this article.
July 15, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27270172/gaba-interneurons-mediate-the-rapid-antidepressant-like-effects-of-scopolamine
#9
Eric S Wohleb, Min Wu, Danielle M Gerhard, Seth R Taylor, Marina R Picciotto, Meenakshi Alreja, Ronald S Duman
Major depressive disorder (MDD) is a recurring psychiatric illness that causes substantial health and socioeconomic burdens. Clinical reports have revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in individuals with MDD. Preclinical models suggest that these rapid antidepressant effects can be recapitulated with blockade of M1-type muscarinic acetylcholine receptors (M1-AChR); however, the cellular mechanisms underlying activity-dependent synaptic and behavioral responses to scopolamine have not been determined...
July 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27161480/high-throughput-cis-regulatory-element-discovery-in-the-vector-mosquito-aedes-aegypti
#10
Susanta K Behura, Joseph Sarro, Ping Li, Keshava Mysore, David W Severson, Scott J Emrich, Molly Duman-Scheel
BACKGROUND: Despite substantial progress in mosquito genomic and genetic research, few cis-regulatory elements (CREs), DNA sequences that control gene expression, have been identified in mosquitoes or other non-model insects. Formaldehyde-assisted isolation of regulatory elements paired with DNA sequencing, FAIRE-seq, is emerging as a powerful new high-throughput tool for global CRE discovery. FAIRE results in the preferential recovery of open chromatin DNA fragments that are not bound by nucleosomes, an evolutionarily conserved indicator of regulatory activity, which are then sequenced...
May 10, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27093965/impedance-ratio-a-novel-marker-and-a-powerful-predictor-of-mortality-in-hemodialysis-patients
#11
COMPARATIVE STUDY
C Demirci, G Aşcı, M S Demirci, M Özkahya, H Töz, S Duman, S Sipahi, S Erten, M Tanrısev, E Ok
PURPOSE: Impedance ratio (Imp-R) obtained by multifrequency bioimpedance analysis (BIA) has been shown to be associated with volume and nutrition status. In this prospective study, the predictive role of Imp-R for mortality in hemodialysis (HD) patients was investigated. METHODS: Multifrequency (5-50-100-200 kHz) BIA was applied to 493 prevalent HD patients in March-April 2006. Imp-R was defined as the ratio of 200-5 kHz impedance values. Demographical, clinical and laboratory data at the time of the analysis were recorded...
July 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27090254/32nd-international-austrian-winter-symposium-zell-am-see-the-netherlands-20-23-january-2016
#12
W Langsteger, A Rezaee, W Loidl, H S Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti, L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W Langsteger, A Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M Hartenbach, T Beyer, K Herrmann, J Czernin, I Rausch, P Rust, M D DiFranco, M Lassen, A Stadlbauer, M E Mayerhöfer, M Hartenbach, M Hacker, T Beyer, K Binzel, R Magnussen, W Wei, M U Knopp, D C Flanigan, C Kaeding, M V Knopp, A Leisser, M Nejabat, M Hartenbach, G Kramer, M Krainer, M Hacker, A Haug, Wencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas Kluge, C L Wright, K Binzel, J Zhang, Evan Wuthrick, Piotr Maniawski, M V Knopp, M Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, R P Baum, B Knäusl, D Georg, M Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O Langer, M Bauer, M Feldmann, R Karch, W Wadsak, M Zeitlinger, M J Koepp, M-C Asselin, E Pataraia, O Langer, M Zeilinger, C Philippe, M Dumanic, F Pichler, J Pilz, M Hacker, W Wadsak, M Mitterhauser, L Nics, B Steiner, M Hacker, M Mitterhauser, W Wadsak, A Traxl, Thomas Wanek, Kushtrim Kryeziu, Severin Mairinger, Johann Stanek, Walter Berger, Claudia Kuntner, Oliver Langer, S Mairinger, T Wanek, A Traxl, M Krohn, J Stanek, T Filip, M Sauberer, C Kuntner, J Pahnke, O Langer, D Svatunek, C Denk, M Wilkovitsch, T Wanek, T Filip, C Kuntner-Hannes, J Fröhlich, H Mikula, C Denk, D Svatunek, T Wanek, S Mairinger, J Stanek, T Filip, J Fröhlich, H Mikula, C Kuntner-Hannes, T Balber, J Singer, J Fazekas, C Rami-Mark, N Berroterán-Infante, E Jensen-Jarolim, W Wadsak, M Hacker, H Viernstein, M Mitterhauser, C Denk, D Svatunek, B Sohr, H Mikula, J Fröhlich, T Wanek, C Kuntner-Hannes, T Filip, S Pfaff, C Philippe, M Mitterhauser, M Hartenbach, M Hacker, W Wadsak, T Wanek, E Halilbasic, M Visentin, S Mairinger, B Stieger, C Kuntner, M Trauner, O Langer, P Lam, M Aistleitner, R Eichinger, C Artner, H Eidherr, C Vraka, A Haug, M Mitterhauser, L Nics, M Hartenbach, M Hacker, W Wadsak, H Kvaternik, R Müller, D Hausberger, C Zink, R M Aigner, U Cossío, M Asensio, A Montes, S Akhtar, Y Te Welscher, R van Nostrum, V Gómez-Vallejo, J Llop, F VandeVyver, T Barclay, N Lippens, M Troch, L Hehenwarter, B Egger, J Holzmannhofer, M Rodrigues-Radischat, C Pirich, N Pötsch, I Rausch, D Wilhelm, M Weber, J Furtner, G Karanikas, A Wöhrer, M Mitterhauser, M Hacker, T Traub-Weidinger, T Cassou-Mounat, S Balogova, V Nataf, M Calzada, V Huchet, K Kerrou, J-Y Devaux, M Mohty, L Garderet, J-N Talbot, S Stanzel, G Pregartner, T Schwarz, V Bjelic-Radisic, B Liegl-Atzwanger, R Aigner, S Stanzel, F Quehenberger, R M Aigner, A Koljević Marković, Milica Janković, V Miler Jerković, M Paskaš, G Pupić, R Džodić, D Popović, M C Fornito, D Familiari, P Koranda, H Polzerová, I Metelková, L Henzlová, R Formánek, E Buriánková, M Kamínek, W H Thomson, C Lewis, W H Thomson, J O'Brien, G James, A Notghi, H Huber, I Stelzmüller, R Wunn, M Mandl, F Fellner, B Lamprecht, M Gabriel, M C Fornito, G Leonardi, W H Thomson, J O'Brien, G James, J Hudzietzová, J Sabol, M Fülöp
A1 68Ga-PSMA PET/CT in staging and restaging of Prostate Cancer Patients: comparative study with 18F-Choline PET/CTW Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M BeheshtiA2 F18 Choline PET - CT: an accurate diagnostic tool for the detection of parathyroid adenoma?L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W LangstegerA3 [18F]Fluoro-DOPA-PET/CT in the primary diagnosis of medullary thyroid carcinomaA Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M HartenbachA4 Variations of clinical PET/MR operations: An international survey on the clinical utilization of PET/MRIT Beyer, K Herrmann, J CzerninA5 Standard Dixon-based attenuation correction in combined PET/MRI: Reproducibility and the possibility of Lean body mass estimationI Rausch, P Rust, MD DiFranco, M Lassen, A Stadlbauer, ME Mayerhöfer, M Hartenbach, M Hacker, T BeyerA6 High resolution digital FDG PET/MRI imaging for assessment of ACL graft viabilityK Binzel, R Magnussen, W Wei, MU Knopp, DC Flanigan, C Kaeding, MV KnoppA7 Using pre-existing hematotoxicity as predictor for severe side effects and number of treatment cycles of Xofigo therapyA Leisser, M Nejabat, M Hartenbach, G Kramer, M Krainer, M Hacker, A HaugA8 QDOSE - comprehensive software solution for internal dose assessmentWencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas KlugeA9 Clinical impact of Time-of-Flight on next-generation digital PET imaging of Yttrium-90 radioactivity following liver radioembolizationCL Wright, K Binzel, J Zhang, Evan Wuthrick, Piotr Maniawski, MV KnoppA10 Snakes in patients! Lessons learned from programming active contours for automated organ segmentationM Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, RP Baum, B Knäusl, D GeorgA11 Influence of a genetic polymorphism on brain uptake of the dual ABCB1/ABCG2 substrate [11C]tariquidarM Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O LangerA12 Outcome prediction of temporal lobe epilepsy surgery from P-glycoprotein activity...
April 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27067013/transiently-increased-glutamate-cycling-in-rat-pfc-is-associated-with-rapid-onset-of-antidepressant-like-effects
#13
G M I Chowdhury, J Zhang, M Thomas, M Banasr, X Ma, B Pittman, L Bristow, E Schaeffer, R S Duman, D L Rothman, K L Behar, G Sanacora
Several drugs have recently been reported to induce rapid antidepressant effects in clinical trials and rodent models. Although the cellular mechanisms involved remain unclear, reports suggest that increased glutamate transmission contributes to these effects. Here, we demonstrate that the antidepressant-like efficacy of three unique drugs, with reported rapid onset antidepressant properties, is coupled with a rapid transient rise in glutamate cycling in the medial prefronal cortex (mPFC) of awake rats as measured by ex vivo (1)H-[(13)C]-nuclear magnetic resonance spectroscopy...
January 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/27049751/the-influence-of-chemical-reactivity-of-surface-defects-on-ambient-stable-inse-based-nanodevices
#14
A Politano, G Chiarello, R Samnakay, G Liu, B Gürbulak, S Duman, A A Balandin, D W Boukhvalov
We demonstrate that, in contrast to most two-dimensional materials, ultrathin flakes of InSe are stable under ambient conditions. Despite their ambient stability, InSe-based nanodevices show an environmental p-type doping, suppressed by capping InSe with hexagonal boron nitride. By means of transport experiments, density functional theory and vibrational spectroscopy, we attribute the p-type doping assumed by uncapped InSe under an ambient atmosphere to the decomposition of water at Se vacancies. We have estimated the site-dependent adsorption energy of O2, N2, H2O, CO and CO2 on InSe...
April 28, 2016: Nanoscale
https://www.readbyqxmd.com/read/26563178/feasibility-of-an-ehealth-application-oncokompas-to-improve-personalized-survivorship-cancer-care
#15
S Duman-Lubberding, C F van Uden-Kraan, F Jansen, B I Witte, L A van der Velden, M Lacko, P Cuijpers, C R Leemans, I M Verdonck-de Leeuw
PURPOSE: The purpose of this study was to investigate the feasibility of an online self-management application (OncoKompas) among cancer survivors. In OncoKompas, cancer survivors can monitor their quality of life (QOL) via participant reported outcomes (PROs) ("Measure"), which is followed by automatically generated individually tailored feedback ("Learn") and personalized advice on supportive care services ("Act"). METHODS: A pretest-posttest design was used, conducting a survey before providing access to OncoKompas, and 2 weeks after, followed by an interview by a nurse...
May 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/26022615/a-micro-patterned-silicon-chip-as-sample-holder-for-macromolecular-crystallography-experiments-with-minimal-background-scattering
#16
P Roedig, I Vartiainen, R Duman, S Panneerselvam, N Stübe, O Lorbeer, M Warmer, G Sutton, D I Stuart, E Weckert, C David, A Wagner, A Meents
At low emittance synchrotron sources it has become possible to perform structure determinations from the measurement of multiple microcrystals which were previously considered too small for diffraction experiments. Conventional mounting techniques do not fulfill the requirements of these new experiments. They significantly contribute to background scattering and it is difficult to locate the crystals, making them incompatible with automated serial crystallography. We have developed a micro-fabricated sample holder from single crystalline silicon with micropores, which carries up to thousands of crystals and significantly reduces the background scattering level...
May 29, 2015: Scientific Reports
https://www.readbyqxmd.com/read/25995833/influence-of-life-stress-5-httlpr-genotype-and-slc6a4-methylation-on-gene-expression-and-stress-response-in-healthy-caucasian-males
#17
Elif A Duman, Turhan Canli
BACKGROUND: Previous research reported that individual differences in the stress response were moderated by an interaction between individuals' life stress experience and the serotonin transporter-linked polymorphic region (5-HTTLPR), a common polymorphism located in the promoter region of the serotonin transporter gene (SLC6A4). Furthermore, this work suggested that individual differences in SLC6A4 DNA methylation could be one underlying mechanism by which stressful life events might regulate gene expression...
2015: Biology of Mood & Anxiety Disorders
https://www.readbyqxmd.com/read/25447377/losing-track-of-time-processing-of-time-reference-inflection-in-agrammatic-and-healthy-speakers-of-german
#18
Laura S Bos, Sandra Hanne, Isabell Wartenburger, Roelien Bastiaanse
BACKGROUND: Individuals with agrammatic aphasia (IWAs) have problems with grammatical decoding of tense inflection. However, these difficulties depend on the time frame that the tense refers to. Verb morphology with reference to the past is more difficult than with reference to the non-past, because a link needs to be made to the past event in discourse, as captured in the PAst DIscourse LInking Hypothesis (PADILIH; Bastiaanse, R., Bamyaci, E., Hsu, C., Lee, J., Yarbay Duman, T., Thompson, C...
December 2014: Neuropsychologia
https://www.readbyqxmd.com/read/25424900/new-functions-and-signaling-mechanisms-for-the-class-of-adhesion-g-protein-coupled-receptors
#19
Ines Liebscher, Brian Ackley, Demet Araç, Donna M Ariestanti, Gabriela Aust, Byoung-il Bae, Bigyan R Bista, James P Bridges, Joseph G Duman, Felix B Engel, Stefanie Giera, André M Goffinet, Randy A Hall, Jörg Hamann, Nicole Hartmann, Hsi-Hsien Lin, Mingyao Liu, Rong Luo, Amit Mogha, Kelly R Monk, Miriam C Peeters, Simone Prömel, Susanne Ressl, Helgi B Schiöth, Séverine M Sigoillot, Helen Song, William S Talbot, Gregory G Tall, James P White, Uwe Wolfrum, Lei Xu, Xianhua Piao
The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGPCRs but one (GPR123) contain a GPCR autoproteolysis-inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation...
December 2014: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/24618807/chronic-corticosterone-exposure-persistently-elevates-the-expression-of-memory-related-genes-in-the-lateral-amygdala-and-enhances-the-consolidation-of-a-pavlovian-fear-memory
#20
Melissa S Monsey, Lara M Boyle, Melinda L Zhang, Caroline P Nguyen, Hope G Kronman, Kristie T Ota, Ronald S Duman, Jane R Taylor, Glenn E Schafe
Chronic exposure to stress has been widely implicated in the development of anxiety disorders, yet relatively little is known about the long-term effects of chronic stress on amygdala-dependent memory formation. Here, we examined the effects of a history of chronic exposure to the stress-associated adrenal steroid corticosterone (CORT) on the consolidation of a fear memory and the expression of memory-related immediate early genes (IEGs) in the lateral nucleus of the amygdala (LA). Rats received chronic exposure to CORT (50 μg/ml) in their drinking water for 2 weeks and were then titrated off the CORT for an additional 6 days followed by a 2 week 'wash-out' period consisting of access to plain water...
2014: PloS One
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