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JOURNAL ARTICLE
S A Codeluppi, M Xu, Y Bansal, A E Lepack, V Duric, M Chow, J Muir, R C Bagot, P Licznerski, S L Wilber, G Sanacora, E Sibille, R S Duman, C Pittenger, M Banasr
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress models. Here, we examine the consequences of PFC GFAP+ cell depletion and cell activity enhancement on depressive-like behaviors in rodents. Using viral expression of diphtheria toxin receptor in PFC GFAP+ cells, which allows experimental depletion of these cells following diphtheria toxin administration, we demonstrated that PFC GFAP+ cell depletion induced anhedonia-like behavior within 2 days and lasting up to 8 days, but no anxiety-like deficits...
September 11, 2023: Molecular Psychiatry
#2
JOURNAL ARTICLE
Manoela V Fogaça, Min Wu, Chan Li, Xiao-Yuan Li, Ronald S Duman, Marina R Picciotto
Alterations in glutamatergic and GABAergic function in the medial prefrontal cortex (mPFC) are prevalent in individuals with major depressive disorder, resulting in impaired synaptic plasticity that compromises the integrity of signal transfer to limbic regions. Scopolamine, a non-selective muscarinic receptor antagonist, produces rapid antidepressant-like effects by targeting M1-type acetylcholine receptors (M1R) on somatostatin (SST) interneurons. So far, these effects have been investigated with relatively short-term manipulations, and long-lasting synaptic mechanisms involved in these responses are still unknown...
May 4, 2023: Neuropsychopharmacology
#3
JOURNAL ARTICLE
N Atilgan, N Duman, T S Colak, I H Korucu, M Demiryurek
OBJECTIVE: In this study, we aimed to evaluate the effectiveness of the modified Kessler technique in managing spaghetti wrist lacerations by multidisciplinary treatment. PATIENTS AND METHODS: Patients who were operated and followed up with the diagnosis of spaghetti wrist tears in our clinic between January 2012 and December 2020 were included in the study. In the postoperative follow-ups, the parameters evaluating the functionality of the patients were examined...
December 2022: European Review for Medical and Pharmacological Sciences
#4
JOURNAL ARTICLE
Polymnia Georgiou, Panos Zanos, Ta-Chung M Mou, Xiaoxian An, Danielle M Gerhard, Dilyan I Dryanovski, Liam E Potter, Jaclyn N Highland, Carleigh E Jenne, Brent W Stewart, Katherine J Pultorak, Peixiong Yuan, Chris F Powels, Jacqueline Lovett, Edna F R Pereira, Sarah M Clark, Leonardo H Tonelli, Ruin Moaddel, Carlos A Zarate, Ronald S Duman, Scott M Thompson, Todd D Gould
We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its bioactive metabolite (2R,6R)-hydroxynorketamine. Mice showed aversion to the scent of male experimenters, preference for the scent of female experimenters and increased stress susceptibility when handled by male experimenters. This human-male-scent-induced aversion and stress susceptibility was mediated by the activation of corticotropin-releasing factor (CRF) neurons in the entorhinal cortex that project to hippocampal area CA1...
September 2022: Nature Neuroscience
#5
JOURNAL ARTICLE
B Mete, A F Kurt, S Urkmez, O Demirkiran, G Can, G Y Dumanli, S Bozbay, H Y Arsu, B Otlu, R Karaali, I I Balkan, N Saltoglu, Y Dikmen, F Tabak, G Aygun
Background: Epidemiology of nosocomial infections may show variability because of under-estimation of infection control measures (ICMs) in coronavirus disease 19 (COVID-19) outbreak. Aim: To investigate the Acinetobacter bacteremia outbreak developed in an intensive care unit (ICU) between March 20 to May 15, 2020, examine the risk factors, and re-evaluate ICM retrospectively. Material and Methods: A retrospective cohort analysis was conducted to determine the risk factors, pulsed field gel electrophoresis (PFGE) was performed for analysis of the outbreak, ICM practices were observed by a team, and infection control interventions were undertaken...
May 2022: Nigerian Journal of Clinical Practice
#6
JOURNAL ARTICLE
B Vona, D A Schwartzbaum, A A Rodriguez, S S Lewis, M B Toosi, P Radhakrishnan, N Bozan, R Akın, M Doosti, R Manju, D Duman, C J Sineni, S Nampoothiri, E G Karimiani, H Houlden, G Bademci, M Tekin, K M Girisha, R Maroofian, S Douzgou
BACKGROUND: Pathogenic variants in KITLG, a crucial protein involved in pigmentation and neural crest cell migration, cause non-syndromic hearing loss, Waardenburg syndrome type 2, familial progressive hyperpigmentation and familial progressive hyper- and hypopigmentation, all of which are inherited in an autosomal dominant manner. OBJECTIVES: To describe the genotypic and clinical spectrum of biallelic KITLG-variants. METHODS: We used a genotype-first approach through the GeneMatcher data sharing platform to collect individuals with biallelic KITLG variants and reviewed the literature for overlapping reports...
May 11, 2022: Journal of the European Academy of Dermatology and Venereology: JEADV
#7
JOURNAL ARTICLE
Matthew P Dannenberg, Dong Yan, Mallory L Barnes, William K Smith, Miriam R Johnston, Russell L Scott, Joel A Biederman, John F Knowles, Xian Wang, Tomer Duman, Marcy E Litvak, John S Kimball, A Park Williams, Yao Zhang
Earth's ecosystems are increasingly threatened by "hot drought," which occurs when hot air temperatures coincide with precipitation deficits, intensifying the hydrological, physiological, and ecological effects of drought by enhancing evaporative losses of soil moisture and increasing plant stress due to higher vapor pressure deficit (VPD). Drought-induced reductions in gross primary production (GPP) exert a major influence on the terrestrial carbon sink, but the extent to which hotter and atmospherically drier conditions will amplify the effects of precipitation deficits on Earth's carbon cycle remains largely unknown...
April 22, 2022: Global Change Biology
#8
JOURNAL ARTICLE
Boyoung Lee, Santosh Pothula, Min Wu, Hyeyeon Kang, Matthew J Girgenti, Marina R Picciotto, Ralph J DiLeone, Jane R Taylor, Ronald S Duman
N-methyl-D-aspartate receptor (NMDAR) modulators have recently received increased attention as potential therapeutics for posttraumatic stress disorder (PTSD). Here, we tested a novel NMDAR-positive modulator, NYX-783, in the following two rodent models of PTSD: an auditory fear-conditioning model and a single-prolonged stress (SPS) model. We examined the ability of NYX-783 to reduce subsequent fear-based behaviors by measuring enhanced fear extinction and reduced spontaneous recovery (spontaneous return of fear) in male mice...
April 14, 2022: Molecular Psychiatry
#9
JOURNAL ARTICLE
Manuela Wiessner, Reza Maroofian, Meng-Yuan Ni, Andrea Pedroni, Juliane S Müller, Rolf Stucka, Christian Beetz, Stephanie Efthymiou, Filippo M Santorelli, Ahmed A Alfares, Changlian Zhu, Anna Uhrova Meszarosova, Elham Alehabib, Somayeh Bakhtiari, Andreas R Janecke, Maria Gabriela Otero, Jin Yun Helen Chen, James T Peterson, Tim M Strom, Peter De Jonghe, Tine Deconinck, Willem De Ridder, Jonathan De Winter, Rossella Pasquariello, Ivana Ricca, Majid Alfadhel, Bart P van de Warrenburg, Ruben Portier, Carsten Bergmann, Saghar Ghasemi Firouzabadi, Sheng Chih Jin, Kaya Bilguvar, Sherifa Hamed, Mohammed Abdelhameed, Nourelhoda A Haridy, Shazia Maqbool, Fatima Rahman, Najwa Anwar, Jenny Carmichael, Alistair T Pagnamenta, Nick W Wood, Frederic Tran Mau-Them, Tobias Haack, Maja Di Rocco, Isabella Ceccherini, Michele Iacomino, Federico Zara, Vincenzo Salpietro, Marcello Scala, Marta Rusmini, Yiran Xu, Yinghong Wang, Yasuhiro Suzuki, Kishin Koh, Haitian Nan, Hiroyuki Ishiura, Shoji Tsuji, Laëtitia Lambert, Emmanuelle Schmitt, Elodie Lacaze, Hanna Küpper, David Dredge, Cara Skraban, Amy Goldstein, Mary J H Willis, Katheryn Grand, John M Graham, Richard A Lewis, Francisca Millan, Özgür Duman, Nihal Olgac Dundar, Gökhan Uyanik, Ludger Schöls, Peter Nürnberg, Gudrun Nürnberg, Andrea Català-Bordes, Pavel Seeman, Martin Kuchar, Hossein Darvish, Adriana Rebelo, Filipa Bouçanova, Jean-Jacques Medard, Roman Chrast, Michaela Auer-Grumbach, Fowzan S Alkuraya, Hanan Shamseldin, Saeed Al Tala, Jamileh Rezazadeh Varaghchi, Maryam Najafi, Selina Deschner, Dieter Gläser, Wolfgang Hüttel, Michael C Kruer, Erik-Jan Kamsteeg, Yoshihisa Takiyama, Stephan Züchner, Jonathan Baets, Matthis Synofzik, Rebecca Schüle, Rita Horvath, Henry Houlden, Luca Bartesaghi, Hwei-Jen Lee, Konstantinos Ampatzis, Tyler Mark Pierson, Jan Senderek
No abstract text is available yet for this article.
September 4, 2021: Brain
#10
JOURNAL ARTICLE
M C Sabaner, R Duman, M Dogan, M Akdogan, A Vurmaz, E Bozkurt, S Beysel
PURPOSE: To evaluate the effects of metformin alone and combined treatment with metformin and an SGLT2 inhibitor on retinal microvascular morphology using optical coherence tomography angiography (OCTA) in isolated type 2 diabetes mellitus (DM) patients with HbA1c above the expected target (>7%). METHODS: Fifty patients with isolated DM, 7%<HbA1c<8%, without diabetic retinopathy (DR) using 500mg metformin ×2 for glycemic control were included in the study...
July 6, 2021: Journal Français D'ophtalmologie
#11
JOURNAL ARTICLE
Manuela Wiessner, Reza Maroofian, Meng-Yuan Ni, Andrea Pedroni, Juliane S Müller, Rolf Stucka, Christian Beetz, Stephanie Efthymiou, Filippo M Santorelli, Ahmed A Alfares, Changlian Zhu, Anna Uhrova Meszarosova, Elham Alehabib, Somayeh Bakhtiari, Andreas R Janecke, Maria Gabriela Otero, Jin Yun Helen Chen, James T Peterson, Tim M Strom, Peter De Jonghe, Tine Deconinck, Willem De Ridder, Jonathan De Winter, Rossella Pasquariello, Ivana Ricca, Majid Alfadhel, Bart P van de Warrenburg, Ruben Portier, Carsten Bergmann, Saghar Ghasemi Firouzabadi, Sheng Chih Jin, Kaya Bilguvar, Sherifa Hamed, Mohammed Abdelhameed, Nourelhoda A Haridy, Shazia Maqbool, Fatima Rahman, Najwa Anwar, Jenny Carmichael, Alistair Pagnamenta, Nick W Wood, Frederic Tran Mau-Them, Tobias Haack, Maja Di Rocco, Isabella Ceccherini, Michele Iacomino, Federico Zara, Vincenzo Salpietro, Marcello Scala, Marta Rusmini, Yiran Xu, Yinghong Wang, Yasuhiro Suzuki, Kishin Koh, Haitian Nan, Hiroyuki Ishiura, Shoji Tsuji, Laëtitia Lambert, Emmanuelle Schmitt, Elodie Lacaze, Hanna Küpper, David Dredge, Cara Skraban, Amy Goldstein, Mary J H Willis, Katheryn Grand, John M Graham, Richard A Lewis, Francisca Millan, Özgür Duman, Nihal Dündar, Gökhan Uyanik, Ludger Schöls, Peter Nürnberg, Gudrun Nürnberg, Andrea Catala Bordes, Pavel Seeman, Martin Kuchar, Hossein Darvish, Adriana Rebelo, Filipa Bouçanova, Jean-Jacques Medard, Roman Chrast, Michaela Auer-Grumbach, Fowzan S Alkuraya, Hanan Shamseldin, Saeed Al Tala, Jamileh Rezazadeh Varaghchi, Maryam Najafi, Selina Deschner, Dieter Gläser, Wolfgang Hüttel, Michael C Kruer, Erik-Jan Kamsteeg, Yoshihisa Takiyama, Stephan Züchner, Jonathan Baets, Matthis Synofzik, Rebecca Schüle, Rita Horvath, Henry Houlden, Luca Bartesaghi, Hwei-Jen Lee, Konstantinos Ampatzis, Tyler Mark Pierson, Jan Senderek
Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-containing non-heme oxygenase of unknown specificity and biological significance. We report 25 families containing 34 individuals with neurological disease associated with biallelic HPDL variants. Phenotypes ranged from juvenile-onset pure hereditary spastic paraplegia to infantile-onset spasticity and global developmental delays, sometimes complicated by episodes of neurological and respiratory decompensation. Variants included bona fide pathogenic truncating changes, although most were missense substitutions...
June 22, 2021: Brain
#12
JOURNAL ARTICLE
Canan Duman, Ola B Al-Batayneh, Sajjad Ahmad, Callum S Durward, Angelika Kobylińska, Alexandre R Vieira, Sheree Tredoux, Alev Eda Okutan, Edibe Egil, Elif Ece Kalaoglu, Belen Sirinoglu Capan, Damla Aksit Bicak, Sobia Zafar
BACKGROUND: The number of child abuse cases is increasing worldwide therefore it is important to educate individuals having contact with children about it. This includes dentists who play a pivotal role in detecting and reporting these cases. AIM: To identify and compare the final year dental student's knowledge, attitudes and practice in relation to child abuse. DESIGN: A 38-item and four part online questionnaire was distributed to students of 11 dental schools in 10 countries...
March 17, 2021: International Journal of Paediatric Dentistry
#13
JOURNAL ARTICLE
Seda Duman, Güner Ekiz, Sinem Yılmaz, Hasan Yusufoglu, Petek Ballar Kırmızıbayrak, Erdal Bedir
Cycloastragenol [20(R),24(S)-epoxy-3β,6α,16β,25-tetrahydroxycycloartane] (CA), the principle sapogenol of many cycloartane-type glycosides found in Astragalus genus, is currently the only natural product in the anti-aging market as telomerase activator. Here, we report biotransformation of 20(27)-octanor-cycloastragenol (1), a thermal degradation product of CA, using Astragalus species originated endophytic fungi, viz. Penicillium roseopurpureum, Alternaria eureka, Neosartorya hiratsukae and Camarosporium laburnicola...
April 2021: Bioorganic Chemistry
#14
JOURNAL ARTICLE
Eftal Murat Bakirci, Husnu Degirmenci, Hakan Duman, Selami Demirelli, Hikmet Hamur, Mutlu Buyuklu, Gokhan Ceyhun, Ergun Kutlusoy
AIMS: To investigate the association of the aortic propagation velocity (APV) with coronary artery disease (CAD) in patients with stable angina pectoris (SAP) through SYNTAX scores (SS). METHODS: The study population comprised 214 SAP subjects who received a coronary angiography. The APV and carotid intima-media thickness (CIMT) were examined and SS was calculated. Subjects were grouped following specific SS criteria: SS less than 22 (low) and SS greater than or equal to 22 (high)...
February 22, 2021: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
#15
JOURNAL ARTICLE
Murray B Stein, Daniel F Levey, Zhongshan Cheng, Frank R Wendt, Kelly Harrington, Gita A Pathak, Kelly Cho, Rachel Quaden, Krishnan Radhakrishnan, Matthew J Girgenti, Yuk-Lam Anne Ho, Daniel Posner, Mihaela Aslan, Ronald S Duman, Hongyu Zhao, Renato Polimanti, John Concato, Joel Gelernter
We conducted genome-wide association analyses of over 250,000 participants of European (EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health record-validated post-traumatic stress disorder (PTSD) diagnosis and quantitative symptom phenotypes. Applying genome-wide multiple testing correction, we identified three significant loci in European case-control analyses and 15 loci in quantitative symptom analyses. Genomic structural equation modeling indicated tight coherence of a PTSD symptom factor that shares genetic variance with a distinct internalizing (mood-anxiety-neuroticism) factor...
February 2021: Nature Genetics
#16
JOURNAL ARTICLE
Does mean platelet volume/lymphocyte count ratio associate with frailty in type 2 diabetes mellitus?
S Bilgin, G Aktas, G Kahveci, B M Atak, O Kurtkulagi, T Taslamacioglu Duman
OBJECTIVES: Frailty is a common problem in patients with type 2 diabetes mellitus (T2DM). It is considered to be associated with inflammation. Novel markers derived from hemogram, such as neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte ratio (MPVLR), are proposed as inflammatory markers. In present study, we aimed to compare NLR and MPVLR levels of frail patients with T2DM to non‑frail diabetic subjects. METHODS: Diabetic subjects were grouped in frail and non-frail groups according to the Edmonton Frail Scale...
2021: Bratislavské Lekárske Listy
#17
JOURNAL ARTICLE
L K Hapairai, K Mysore, L D James, N D Scheel, J S Realey, L Sun, L E Gerber, R S Feng, E Romero-Severson, A Mohammed, M Duman-Scheel, D W Severson
Aedes mosquitoes (Diptera: Culicidae), principle vectors of several arboviruses, typically lay eggs in man-made water-filled containers located near human dwellings. Given the widespread emergence of insecticide resistance, stable and biofriendly alternatives for mosquito larviciding are needed. Laboratory studies have demonstrated that inactivated yeast interfering RNA tablets targeting key larval developmental genes can be used to facilitate effective larvicidal activity while also promoting selective gravid female oviposition behaviour...
December 30, 2020: Medical and Veterinary Entomology
#18
JOURNAL ARTICLE
Matthew J Girgenti, Jiawei Wang, Dingjue Ji, Dianne A Cruz, Murray B Stein, Joel Gelernter, Keith A Young, Bertrand R Huber, Douglas E Williamson, Matthew J Friedman, John H Krystal, Hongyu Zhao, Ronald S Duman
Despite extensive study of the neurobiological correlates of post-traumatic stress disorder (PTSD), little is known about its molecular determinants. Here, differential gene expression and network analyses of four prefrontal cortex subregions from postmortem tissue of people with PTSD demonstrate extensive remodeling of the transcriptomic landscape. A highly connected downregulated set of interneuron transcripts is present in the most significant gene network associated with PTSD. Integration of this dataset with genotype data from the largest PTSD genome-wide association study identified the interneuron synaptic gene ELFN1 as conferring significant genetic liability for PTSD...
January 2021: Nature Neuroscience
#19
JOURNAL ARTICLE
M R Atelge, A E Atabani, Serdar Abut, M Kaya, Cigdem Eskicioglu, Georgeio Semaan, Changsoo Lee, Y Ş Yildiz, S Unalan, R Mohanasundaram, F Duman, Gopalakrishnan Kumar
The effect of oil extraction from spent coffee grounds as a pre-treatment strategy prior to anaerobic digestion besides assessing the feasibility of defatted spent coffee grounds co-digestion with spent tea waste, glycerin, and macroalgae were examined. Mesophilic BMP tests were performed using defatted spent coffee grounds alongside four co-substrates in the ratio of 25, 50, and 75%, respectively. The highest methane yield was obtained with the mono-digestion of defatted spent coffee grounds with 336 ± 7 mL CH4 /g VS and the yield increased with the increase in the mass ratio of defatted spent coffee grounds during co-digestion...
December 3, 2020: Bioresource Technology
#20
JOURNAL ARTICLE
Manoela V Fogaça, Min Wu, Chan Li, Xiao-Yuan Li, Marina R Picciotto, Ronald S Duman
Major depressive disorder (MDD) is associated with alterations of GABAergic interneurons, notably somatostatin (Sst) as well as parvalbumin (Pvalb), in cortical brain areas. In addition, the antidepressant effects of rapid-acting drugs are thought to occur via inhibition of GABA interneurons. However, the impact of these interneuron subtypes in affective behaviors as well as in the effects of rapid-acting antidepressants remains to be determined. Here, we used a Cre-dependent DREADD-chemogenetic approach to determine if inhibition of GABA interneurons in the mPFC of male mice is sufficient to produce antidepressant actions, and conversely if activation of these interneurons blocks the rapid and sustained antidepressant effects of scopolamine, a nonselective acetylcholine muscarinic receptor antagonist...
October 17, 2020: Molecular Psychiatry
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