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https://www.readbyqxmd.com/read/29150952/ck-2127107-amplifies-skeletal-muscle-response-to-nerve-activation-in-humans
#1
Jinsy A Andrews, Timothy M Miller, Vipin Vijayakumar, Randall Stoltz, Joyce K James, Lisa Meng, Andrew A Wolff, Fady I Malik
INTRODUCTION: Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-2127107 (CK-107), a next-generation fast skeletal muscle troponin activator (FSTA), in healthy subjects. We tested the hypothesis that CK-107 would amplify the force-frequency response of muscle in humans. METHODS: To assess the force-frequency response, subjects received single doses of CK-107 and placebo in a randomized, double-blind, 4-period, crossover study...
November 18, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29146221/takedown-of-ankle-arthrodesis-with-insufficient-fibula-surgical-technique-and-intermediate-term-follow-up
#2
John M Schuberth, Jeffrey C Christensen, Chad Seidenstricker
Conversion of ankle arthrodesis to total ankle arthroplasty has recently gained popularity. However, technical challenges are present when treating patients without a sufficient fibular buttress. We describe a technique for restoration of an adequate fibular buttress using an iliac crest bone graft or malleolar relocation. The results of 10 patients with an average follow-up period of 56 (range 24 to 123) months are presented. Of the 10 patients, 3 underwent tricortical iliac bone augmentation of the fibula, 4 underwent repositioning of the remnant fibula, and in 3, the in situ fibula was used...
November 14, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29144538/control-of-hemorrhage-through-the-osteotomy-gap-during-tibial-plateau-leveling-osteotomy-9-cases
#3
Luis Matres-Lorenzo, Aidan McAlinden, Antoine Bernardé, Fabrice Bernard
OBJECTIVE: To describe a new technique to control intraoperative hemorrhage during tibial plateau leveling osteotomy (TPLO) and report subsequent short-term and long-term complications. STUDY DESIGN: Retrospective case series. ANIMALS: Nine dogs with arterial hemorrhage during TPLO. METHODS: Medical records of dogs with hemorrhage controlled through the osteotomy gap of a TPLO were reviewed at 2 institutions over 8 years...
November 16, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29117845/restoration-of-the-active-forearm-rotation-using-vascularized-free-fibular-graft-and-radial-head-arthroplasty-for-a-wide-defect-of-the-proximal-radius
#4
Ryosuke Sato, Yoshitaka Hamada, Naohito Hibino, Toshihiko Nishisho, Ichiro Tonogai, Kenji Endo, Koichi Sairyo
In this report we present a case of re-stabilization of the proximal radius using vascularized free fibular graft combined with anconeus arthroplasty to stabilize the transplanted fibula in a patient with large loss of the proximal radius due to Ewing's sarcoma. A 20-year-old woman had Ewing's sarcoma in the proximal three-fourths of the radius. The resection of large part of the radius containing radial head were necessary for removal of the sarcoma. Reconstruction of the proximal radius was performed using vascularized free fibular graft and the transplanted fibula was stabilized by attaching the anconeus to the proximal edge of the fibula...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29114187/use-of-fibular-bone-graft-and-cancellous-screw-fixation-in-the-management-of-neglected-femur-neck-fractures-in-young-patients
#5
Ghulam Mustafa Kaim Khani, Kamran Hafeez, Muhammad Bux, Nusrat Rasheed, Naveed Ahmed, M Perwez Anjum
Objective: To present the clinical outcome of patients with neglected femur neck fracture treated with fibular bone graft. Methods: During May 2010-February 2013, 15 patients younger than 35 years of age with neglected fracture neck of femur were managed with non-vascularized fibular graft and cannulated screws. Fractures were classified according to Sandhu Classification. Hip function was assessed using Harris hip score. Results: Fifteen patients with mean age of 28...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29113176/stereolithographic-model-assisted-reconstruction-of-the-mandibular-condyle-with-a-vascularized-fibular-flap-following-hemimandibulectomy-evaluation-of-morphological-and-functional-outcomes
#6
Hitoshi Yoshimura, Shinpei Matsuda, Seigo Ohba, Yoshiki Minegishi, Kunihiro Nakai, Shigeharu Fujieda, Kazuo Sano
The vascularized fibular flap is one of the standard treatment choices for the reconstruction of the mandible; however, the consequences of condylar restoration have not previously been reported. The use of three-dimensional models allows for a more predictable reconstruction. The purpose of the present study was to assess the outcome of stereolithographic model-assisted reconstruction of the mandibular condyle with a vascularized fibular flap. A total of 5 patients underwent mandibular resection including the condyle and immediate reconstruction with a vascularized fibular flap...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110910/treatment-of-giant-cell-tumor-of-distal-radius-with-limited-soft-tissue-invasion-curettage-and-cementing-versus-wide-excision
#7
Kamran Mozaffarian, Mehra Modjallal, Amir Reza Vosoughi
BACKGROUND: Intralesional curettage and adjuvant versus wide en bloc excision (WEE) as the best treatment method of giant cell tumor (GCT) of distal radius with limited soft tissue extension is a controversial topic. METHODS: Prospectively, 13 patients who had GCT of distal radius with perforation of either volar or dorsal cortex of the bone and soft tissue extension which was confined to one plane were enrolled in the study. Six patients treated with ICC and seven cases cured by WEE technique and proximal fibular arthroplasty...
October 27, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29093784/sagittal-alignment-of-a-strut-graft-affects-graft-subsidence-and-clinical-outcomes-of-anterior-cervical-corpectomy-and-fusion
#8
Koun Yamauchi, Kazunari Fushimi, Kei Miyamoto, Akira Hioki, Katsuji Shimizu, Haruhiko Akiyama
Study Design: Retrospective study. Purpose: The purpose of this study was to investigate the influence of sagittal alignment of the strut graft on graft subsidence and clinical outcomes after anterior cervical corpectomy and fusion (ACCF). Overview of Literature: ACCF is a common technique for the treatment of various cervical pathologies. Although graft subsidence sometimes occurs after ACCF, it is one cause for poor clinical results. Malalignment of the strut graft is probably one of the factors associated with graft subsidence...
October 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29089670/complications-exclusive-to-long-strut-grafts-used-following-multilevel-cervical-corpectomy-utilization-of-advanced-imaging-techniques
#9
Pushpa B Thippeswamy, Sunitha P Kumaran, Vinay Hegde, Sanjaya Viswamitra
When surgical decompression of cervical spine is considered, multilevel cervical corpectomy with long strut grafts is the preferred treatment. This procedure is used in a variety of pathologies including degenerative disease, tumors, trauma and infection. Corpectomy with interbody grafting helps in adequate spinal canal and neural decompression compared to multilevel discectomy, which could be difficult as well as inadequate. Fibular/iliac strut grafts are used for reconstruction along with a stabilizing hardware in this procedure...
July 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29082822/endovascular-treatment-of-penetrating-arterial-trauma-with-stent-grafts
#10
Rodrigo Bruno Biagioni, Marcelo Calil Burihan, Felipe Nasser, Luisa Ciucci Biagioni, José Carlos Ingrund
BACKGROUND: The endovascular management of arterial injuries has resulted in reduced operating time, blood loss, hospital mortality, lower incidence of sepsis, and decrease in mortality rates. For penetrating trauma, however, the benefits of endovascular therapy are questionable. PATIENTS AND METHODS: Data were obtained by retrospective analysis of electronic medical records. All patients with vascular trauma seeking care at our institution from January 2010 to December 2015 were reviewed...
October 30, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29079243/lateral-ligament-reconstruction-for-ball-and-socket-ankle-accompanying-lateral-ankle-instability-a-case-report-and-literature%C3%A2-review
#11
Onur Kocadal, Arzu Ozsoy, Hakan Ozsoy
The ball-and-socket ankle joint is a rare deformity characterized by the loss of concavity in the trochlear surface of the talus with rounding of the articular surfaces of the distal fibula and tibia. Frequently, tarsal coalitions, fibular hypoplasia, and shortening of the limb accompany this deformity. To date, no data have been reported on surgical treatment of lateral ankle joint instability and peroneal tendon dislocation concomitant with a ball-and-socket ankle joint. In the present study, we report the case of a 43-year-old male patient with right lateral ankle joint instability and peroneal tendon dislocation in a ball-and-socket ankle joint, with accompanying tarsal coalition...
November 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29079242/fibulocalcaneal-impingement-in-a-growing-child-with-otherwise-asymptomatic-talocalcaneal-coalition
#12
G Ulrich Exner, Hilaire A C Jacob, Gerardo J Maquieira
Subfibular impingement has been described in patients with flatfoot. It possibly occurs with valgus deformity associated with talocalcaneal coalition. We observed symptomatic unilateral fibular impingement initially on the left foot of an 11-year-old female with an otherwise asymptomatic bilateral talocalcaneal coalition. From the age of 8 years, she had complained of pain around the left fibular tip. Magnetic resonance imaging showed a partial talocalcaneal coalition. At 10 years of age, it was questioned whether the pain was related to the coalition...
November 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29076982/reconstruction-of-traumatic-open-supracondylar-femoral-fractures-by-autologous-fibular-strut-grafting-and-cortico-cancellous-bone-grafting-a-single-centre-observational-study
#13
Raju Iyengar, Nagesh Cherukuri, Chandrasekar Patnala
OBJECTIVES: To study the safety and efficacy of staged reconstruction of distal femoral (supracondylar) bone loss using autologous fibular strut, cortico-cancellous bone grafting. DESIGN: Single Centre, Observational study, with review of literature. SETTING: Urban Level I Trauma Centre,Patients/Participants. 18 consecutive patients (mean age: 35± 8.5 years, all males) with open supracondylar fracture and intercondylar extension (Type C3), (AO type) operated between January 2010 and February 2014 with severe bone loss in 11 patients and moderate loss in 7...
September 25, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29062213/antiglide-versus-lateral-plate-fixation-for-danis-weber-type-b-malleolar-fractures-caused-by-supination-external-rotation-injury
#14
Miroslav Kilian, Peter Csörgö, Silvia Vajczikova, Jan Luha, Radoslav Zamborsky
PURPOSE: The purpose of this study was to evaluate functional results and the frequency of complications in the distal fibula Danis-Weber type B fractures caused by supination-external rotation injury in a group of lateral and antiglide plate fixation. METHODS: This prospective study evaluated 44 patients with a minimum of one-year follow-up. Patients were divided into two groups: one lateral plate group (24 patients) and group with an antiglide plate (20 patients)...
October 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29058759/implant-failure-rates-and-cost-analysis-of-contoured-locking-versus-conventional-plate-fixation-of-distal-fibula-fractures
#15
Lewis K Moss, Michael H Kim-Orden, Robert Ravinsky, Christopher M Hoshino, Daniel M Zinar, Stuart M Gold
The authors analyzed 330 consecutive Weber B distal fibula fractures that occurred during a 3-year period and were treated with either a contoured locking plate or a conventional one-third tubular plate to compare the cost and failure rates of the 2 constructs. The primary outcomes were failure of the distal fibular implant and loss of reduction. Secondary outcomes were surgical wound infection requiring surgical debridement and/or removal of the fibular implant, and removal of the fibular plate for persistent implant-related symptoms...
October 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/29053880/electrodiagnostic-errors-contribute-to-cidp-misdiagnosis
#16
Jeffrey A Allen, John Ney, Richard A Lewis
INTRODUCTION: Documentation of peripheral nerve demyelination is an important part of the CIDP diagnostic process. METHODS: We performed a retrospective analysis of patients referred with a diagnosis of CIDP who were found to have a different condition. Electrodiagnostic study data and interpretations performed at the time of the initial diagnosis were compared to those obtained during the re-evaluation. RESULTS: Thirty-nine of 86 patients were found to not have CIDP...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053502/the-community-orthopaedic-surgeon-taking-trauma-call-pediatric-ankle-fracture-pearls-and-pitfalls
#17
Shital N Parikh, Charles T Mehlman
Pediatric ankle fractures are common and have unique fracture characteristics because of the presence of distal tibial and fibular physes. When displaced (>3 mm widening of the physis or >2 mm intra-articular gap/step-off), these fractures are typically treated with anatomical reduction and internal fixation. Computed tomography is recommended for preoperative evaluation and surgical planning for intra-articular fractures. These fractures in younger children with substantial growth remaining should be followed closely to monitor for any growth disturbance...
November 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29037924/-all-inside-arthroscopic-treatment-of-tillaux-chaput-fractures-clinical-experience-and-outcomes-analysis
#18
Shi-Ming Feng, Qing-Qing Sun, Ai-Guo Wang, Cheng-Kun Li
We investigated all-inside ankle arthroscopy for Tillaux-Chaput fractures. We retrospectively evaluated 19 patients (12 males [63.2%] and 7 [36.8%] females; 11 right [57.9%] and 8 left [42.1%] ankles) treated from May 2013 to January 2016. Their mean age was 28.1 (range 10 to 55) years. Sixteen (84.2%) had single Tillaux-Chaput fractures and 3 (15.8%) had combined proximal fibular fractures; 17 (89.5%) were diagnosed radiographically and 2 (10.5%) by computed tomography. Anterolateral and anteromedial ankle arthroscopy was used for closed reduction and internal fixation with 1 or 2 Herbert screws...
October 13, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29037091/an-anthropometric-survey-of-u-s-preterm-and-full-term-neonates
#19
Susan M Abdel-Rahman, Ian M Paul, Paula Delmore, Laura James, Laura Fearn, Andrew M Atz, Brenda B Poindexter, Amira Al-Uzri, Andrew Lewandowski, Barrie L Harper, P Brian Smith
BACKGROUND: Anthropometric data prove valuable for screening and monitoring various medical conditions. In young infants, however, only weight, length and head circumference are represented in publically accessible databases. AIM: To characterise length and circumferential measures in preterm and full-term infants up to 90 days postnatal age. SUBJECTS AND METHODS: In eight U.S. medical centres, trained raters recorded humeral, ulnar, femoral, tibial, and fibular lengths along with mid-upper arm, mid-thigh, chest, abdominal, and neck circumference...
October 16, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/29026835/recurrent-aneurysmal-bone-cyst-of-talus-resulted-in-tibiotalocalcaneal-arthrodesis
#20
Amir R Vosoughi, Kamran Mozaffarian, Mohammad A Erfani
Aneurysmal bone cyst (ABC), a locally benign aggressive lytic lesion of either primary or secondary origin, seldom involves the talus. Herein, we present a 25-year-old man with recurrent ABC of the talus after curettage and bone grafting, which was managed by total resection followed by filling the defect using fibular graft and finally tibiotalocalcaneal arthrodesis due to articular surface involvement. At 18 mo postoperatively, no recurrence was detected. Arthrodesis might be a good option in cases with recurrent ABC of the talus especially with articular surface involvement...
September 16, 2017: World Journal of Clinical Cases
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