Pierre Agnass, Eran van Veldhuisen, Jantien A Vogel, H Petra Kok, Mark J de Keijzer, Gerben Schooneveldt, Lianne R de Haan, John H Klaessens, Hester J Scheffer, Martijn R Meijerink, Krijn P van Lienden, Thomas M van Gulik, Michal Heger, Johannes Crezee, Marc G Besselink
Aims: First, the aim of the study was to determine whether irreversible electroporation (IRE) is associated with heat generation in the liver and pancreas at clinical (≤1,500 V/cm) and supraclinical (>1,500 V/cm) electroporation settings; second, to assess the risk of thermal tissue damage in and adjacent to the treated volume in highly perfused versus moderately perfused parts of both organs; third, to investigate the influence of perfusion and of the presence and the orientation of a metal stent on the maximal thermal elevation (ΔTSession,max ) in the tissue during an IRE session at fixed IRE settings, and finally, to determine whether the maximum temperature elevation within the IRE-subjected organ during an IRE treatment (single or multiple sessions) is reflected in the organ's surface temperature...
April 13, 2020: Journal of Clinical and Translational Research