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https://www.readbyqxmd.com/read/27343043/subarachnoid-hemorrhage-from-dissecting-aneurysm-of-the-posterior-communicating-artery
#1
Keisuke Kadooka, Michihiro Tanaka, Kenji Shimada, Hiromu Hadeishi
A 36-year-old woman on chronic hemodialysis presented with sudden onset of headache and deterioration of consciousness. She was sent to our hospital on day 1, with subarachnoid hemorrhage. Cerebral angiography showed pearl and string sign on the left posterior communicating artery, which was consistent with a diagnosis of hemorrhage from a dissecting aneurysm of the left posterior communicating artery. She underwent parent artery occlusion via endovascular treatment on day 2. Although cone beam computed tomography before embolization showed a perforator from the lesion, there were no ischemic lesions on diffusion-weighted imaging after the procedure...
October 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27058885/factors-associated-with-long-term-functional-and-psychological-outcomes-in-persons-with-moderate-to-severe-traumatic-brain-injury
#2
Fary Khan, Bhasker Amatya, Rodney Judson, Pearl Chung, Melinda Truesdale, Alaeldin Elmalik, Mary P Galea
OBJECTIVE: To examine factors impacting long-term functional and psychological outcomes in persons with moderate-severe traumatic brain injury. METHODS: A prospective cross-sectional study (n = 103) assessed the long-term (up to 5 years) impact of traumatic brain injury on participants' current activity and restriction in participation using validated questionnaires. RESULTS: Participants' median age was 49.5 years (interquartile range (IQR) 20...
April 28, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27019697/epileptogenesis-in-neurocutaneous-disorders-with-focus-in-sturge-weber-syndrome
#3
REVIEW
Anna Pinto, Mustafa Sahin, Phillip L Pearl
Epilepsy is a major morbidity in Sturge Weber syndrome, a segmental vascular neurocutaneous disorder classically associated with facial angiomas, glaucoma, and leptomeningeal capillary-venous type vascular malformations. The extent of the latter correlates with neurological outcome. Post-zygotic mosaicism for the activating mutation p.R183Q of the GNAQ gene has been identified as the major cause.  GNAQ encodes for an alpha subunit of a heterotrimeric G protein critical to blood vessel development. The earlier the timing of the mutation in development, the more severe the involvement, e...
2016: F1000Research
https://www.readbyqxmd.com/read/26722676/posterior-interhemispheric-approach-and-microsurgical-resection-of-a-pineal-parenchymal-neoplasm-of-intermediate-differentiation
#4
Anil Nanda, Subhas Konar, Piyush Kalakoti, Tanmoy Maiti
Owing to a deep-seated location and intricate venous anatomy, pathologies of the posterior third ventricular region pose formidable challenges to the operating neurosurgeon. In this video, we present a case of an elderly Caucasian female with a rare histological variant of a pineal parenchymal mass who presented with gait disturbances and worsening retro-orbital headache. Radiological and clinco-histopathological correlates of this rare tumor pathology having intermediate differentiation are highlighted. Briefly outlined are surgical pearls and strategies to minimize complications, as the tumor is approached through the posterior interhemispheric corridor, to achieve a gross-total decompression...
January 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/26001982/healthcare-use-for-acute-gastrointestinal-illness-in-two-inuit-communities-rigolet-and-iqaluit-canada
#5
Sherilee L Harper, Victoria L Edge, James Ford, M Kate Thomas, David Pearl, Jamal Shirley, Scott A McEwen
BACKGROUND: The incidence of self-reported acute gastrointestinal illness (AGI) in Rigolet, Nunatsiavut, and Iqaluit, Nunavut, is higher than reported elsewhere in Canada; as such, understanding AGI-related healthcare use is important for healthcare provision, public health practice and surveillance of AGI. OBJECTIVES: This study described symptoms, severity and duration of self-reported AGI in the general population and examined the incidence and factors associated with healthcare utilization for AGI in these 2 Inuit communities...
2015: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/25837829/ombitasvir-plus-paritaprevir-plus-ritonavir-with-or-without-ribavirin-in-treatment-naive-and-treatment-experienced-patients-with-genotype-4-chronic-hepatitis-c-virus-infection-pearl-i-a-randomised-open-label-trial
#6
RANDOMIZED CONTROLLED TRIAL
Christophe Hézode, Tarik Asselah, K Rajender Reddy, Tarek Hassanein, Marina Berenguer, Katarzyna Fleischer-Stepniewska, Patrick Marcellin, Coleen Hall, Gretja Schnell, Tami Pilot-Matias, Niloufar Mobashery, Rebecca Redman, Regis A Vilchez, Stanislas Pol
BACKGROUND: Hepatitis C virus (HCV) genotype 4 accounts for about 13% of global HCV infections. Because interferon-containing treatments for genotype 4 infection have low efficacy and poor tolerability, an unmet need exists for effective all-oral regimens. We examined the efficacy and safety of an all-oral interferon-free regimen of ombitasvir, an NS5A inhibitor, and paritaprevir (ABT-450), an NS3/4A protease inhibitor dosed with ritonavir (ombitasvir plus paritaprevir plus ritonavir), given with or without ribavirin...
June 20, 2015: Lancet
https://www.readbyqxmd.com/read/25313381/pearls-oy-sters-cough-headache-secondary-to-chiari-malformation-type-i
#7
James E Bates, Erika F Augustine
No abstract text is available yet for this article.
October 14, 2014: Neurology
https://www.readbyqxmd.com/read/24945935/endoscopic-forehead-approach-for-minimally-invasive-benign-tumor-excisions
#8
MULTICENTER STUDY
Haneen Sadick, Michael Huber, Stephen W Perkins, Heather H Waters, Grant S Hamilton, Ashley G O'Reilly, Holger G Gassner
IMPORTANCE: Direct transcutaneous resection has been a widely accepted standard for the removal of benign forehead lesions. In recent years, the endoscopic approach has become more prevalent because of its noninvasiveness. To date, only a few studies with limited case numbers have reported on this technique. We report our findings from one of the largest cohorts of patients undergoing tumor resection of the forehead via the endoscopic approach. OBJECTIVES: To evaluate results of the endoscopic forehead approach for benign tumor excisions, to give a more nuanced insight into this procedure, and to discuss technical pearls and potential pitfalls from our experience...
September 2014: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/24833212/spontaneous-vertebral-artery-dissection-with-thunderclap-headache-a-case-report-and-review-of-the-literature
#9
REVIEW
Yung-Chu Hsu, Sheng-Feng Sung
PURPOSE: Vertebral artery dissection (VAD) is an important and under-recognized etiology of stroke in young patients. No clinical symptoms or signs appear to be specific for VAD. This report describes a representative patient and reviews the headache pattern and imaging findings commonly noted in VAD to help with the early diagnosis of VAD. CASE REPORT: A 44-year-old female presented with severe right posterior neck pain and vertigo followed closely by thunderclap headache that was confirmed as right VAD (V4 segment) with delayed right dorsal medullary infarction two days later...
March 2014: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/24795200/abt-450-r-ombitasvir-and-dasabuvir-with-or-without-ribavirin-for-hcv
#10
RANDOMIZED CONTROLLED TRIAL
Peter Ferenci, David Bernstein, Jacob Lalezari, Daniel Cohen, Yan Luo, Curtis Cooper, Edward Tam, Rui T Marinho, Naoky Tsai, Anders Nyberg, Terry D Box, Ziad Younes, Pedram Enayati, Sinikka Green, Yaacov Baruch, Bal Raj Bhandari, Florin Alexandru Caruntu, Thomas Sepe, Vladimir Chulanov, Ewa Janczewska, Giuliano Rizzardini, Judit Gervain, Ramon Planas, Christophe Moreno, Tarek Hassanein, Wangang Xie, Martin King, Thomas Podsadecki, K Rajender Reddy
BACKGROUND: The interferon-free regimen of ABT-450 with ritonavir (ABT-450/r), ombitasvir, and dasabuvir with or without ribavirin has shown efficacy in inducing a sustained virologic response in a phase 2 study involving patients with hepatitis C virus (HCV) genotype 1 infection. We conducted two phase 3 trials to examine the efficacy and safety of this regimen in previously untreated patients with HCV genotype 1 infection and no cirrhosis. METHODS: We randomly assigned 419 patients with HCV genotype 1b infection (PEARL-III study) and 305 patients with genotype 1a infection (PEARL-IV study) to 12 weeks of ABT-450/r-ombitasvir (at a once-daily dose of 150 mg of ABT-450, 100 mg of ritonavir, and 25 mg of ombitasvir), dasabuvir (250 mg twice daily), and ribavirin administered according to body weight or to matching placebo for ribavirin...
May 22, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24784719/effect-of-a-low-dose-contraceptive-patch-on-efficacy-bleeding-pattern-and-safety-a-1-year-multicenter-open-label-uncontrolled-study
#11
MULTICENTER STUDY
Inka Wiegratz, Susana Bassol, Edith Weisberg, Uwe Mellinger, Martin Merz
This Phase III, uncontrolled, open-label, multicenter study was conducted to investigate the contraceptive efficacy, bleeding pattern, and cycle control of a novel once-a-week contraceptive patch, delivering low-dose ethinyl estradiol (EE) and gestodene (GSD) at the same systemic exposure seen after oral administration of a combined oral contraceptive containing 0.02 mg EE/0.06 mg GSD. Participants were women aged 18 to 35 years, all of whom received the EE/GSD patch for 13 cycles each of 21 treatment days (one patch per week for 3 weeks) followed by a 7-day, patch-free interval...
December 2014: Reproductive Sciences
https://www.readbyqxmd.com/read/24246496/parkinson-syndrome-a-precise-localization-for-abducens-palsy
#12
Venugopalan Y Vishnu, Gayathri Petluri, Vivek Gupta, Vivek Lal, Dheeraj Khurana, Manoj Kumar Goyal
BACKGROUND: Unilateral isolated abducens palsy can occur due to any lesion from pons to orbit. The precise localization is made through the associated neurological signs. Parkinson syndrome is a symptom complex of unilateral abducens palsy with ipsilateral postganglionic Horner syndrome localizing the lesion to posterior cavernous sinus. RESULTS: We describe here a 55 year old lady who presented with headache and diplopia for 3 months. On examination she had right lateral rectus palsy and postganglionic Horner syndrome...
January 15, 2014: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/24044082/solitary-ruptured-aneurysm-of-the-spinal-artery-of-adamkiewicz-with-subarachnoid-hemorrhage
#13
Seong Son, Sang-Gu Lee, Cheol-Wan Park
Spinal subarachnoid hemorrhage (SAH) due to solitary spinal aneurysm is extremely rare. A 45-year-old female patient visited the emergency department with severe headache and back pain. Imaging studies showed cerebral SAH in parietal lobe and spinal SAH in thoracolumbar level. Spinal angiography revealed a small pearl and string-like aneurysm of the Adamkiewicz artery at the T12 level. One month after onset, her back pain aggravated, and follow-up imaging study showed arachnoiditis. Two months after onset, her symptoms improved, and follow-up imaging study showed resolution of SAH...
July 2013: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/24021081/-epidermoid-neoplasm-of-the-fourth-ventricle-report-of-two-cases
#14
Jorge Arturo Santos-Franco, Cristóbal Vallejo-Moncada, Griselda Collado-Arce, Edgar Villalpando-Navarrete, M Sandoval-Balanzario
BACKGROUND: epidermoid neoplasm (EN) accounts for 1 % of whole intracranial neoplasms. Usually, it is found at the cerebello-pontine angle and the location in the fourth ventricle (FV) is rare. The aim was to report two cases of EN of the FV. CLINICAL CASES: case 1: a female 22 year old presented with an intense headache with a history of 3 months. At the hospital entry, symptoms and signs of high intracranial pressure were found. Tomography images showed hydrocephalus with high pressure in the FV...
July 2013: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/23876024/results-of-phase-ii-levetiracetam-trial-following-acute-head-injury-in-children-at-risk-for-posttraumatic-epilepsy
#15
Phillip L Pearl, Robert McCarter, Colleen L McGavin, Yuezhou Yu, Fabian Sandoval, Stacey Trzcinski, Shireen M Atabaki, Tammy Tsuchida, John van den Anker, Jianping He, Pavel Klein
Posttraumatic seizures develop in up to 20% of children following severe traumatic brain injury (TBI). Children ages 6-17 years with one or more risk factors for the development of posttraumatic epilepsy, including presence of intracranial hemorrhage, depressed skull fracture, penetrating injury, or occurrence of posttraumatic seizure were recruited into this phase II study. Treatment subjects received levetiracetam 55 mg/kg/day, b.i.d., for 30 days, starting within 8 h postinjury. The recruitment goal was 20 treated patients...
September 2013: Epilepsia
https://www.readbyqxmd.com/read/23741259/intracranial-epidermoid-tumor-microneurosurgical-management-an-experience-of-23-cases
#16
Forhad Hossain Chowdhury, Mohammod Raziul Haque, Mainul Haque Sarker
OBJECTIVES: An intracranial epidermoid tumor is relatively a rare tumor, accounting for approximately 0.1% of all intracranial space occupying lesions. These are also known as pearly tumor due to their pearl like appearance. In this series, the localization of the tumor, presenting age and symptoms, imaging criteria for diagnosis, surgical management strategy with completeness of excision and overall outcome were studied prospectively. Here, we report our short experience of intracranial epidermoid as a whole...
January 2013: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/23671256/pearls-and-pitfalls-in-experimental-models-of-spreading-depression
#17
Cenk Ayata
BACKGROUND: Spreading depression (SD) is the electrophysiological substrate of migraine aura and a potential trigger for headache. Since its discovery by Leão in 1944, SD has transformed from being viewed as an epiphenomenon into a therapeutic target relevant in the pathophysiology of migraine and brain injury. AIM: Despite decades of research, the underpinnings of SD are still poorly understood, hampering our efforts to selectively block its initiation and spread...
June 2013: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/23671254/pearls-and-pitfalls-in-experimental-in-vivo-models-of-migraine-dural-trigeminovascular-nociception
#18
Simon Akerman, Philip R Holland, Jan Hoffmann
BACKGROUND: Migraine is a disorder of the brain and is thought to involve activation of the trigeminovascular system, which includes the peripheral afferent projection to the nociceptive specific dura mater, as well as the central afferent projection to the trigeminal nucleus caudalis. Stimulation of the blood vessels of the dura mater produces pain in patients that is referred to the head similar to headache. HEADACHE MECHANISMS: The likely reason for the pain is because the vascular structures of the dura mater, including the superior sagittal sinus and middle meningeal artery, are richly innervated by a plexus of largely unmyelinated sensory nerve fibers from the ophthalmic division of the trigeminal ganglion...
June 2013: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/23671253/pearls-and-pitfalls-in-experimental-in-vivo-models-of-headache-conscious-behavioral-research
#19
Marcela Romero-Reyes, Yi Ye
BACKGROUND: Physiological studies have been determinant for the understanding of migraine pathophysiology and the screening of novel therapeutics. At present, there is no animal model that translates fully the clinical symptoms of migraine, and generally these studies are conducted on anesthetized animals. METHODOLOGY: Pain as well as non-painful symptoms such as photophobia, need to have a conscious individual to be experienced; therefore, the new development and adaptation of behavioral assays assessing pain and other non-painful symptomatology in conscious animals represents a great opportunity for headache research and it is exciting that more and more researchers are using behavioral paradigms...
June 2013: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/23671252/pearls-and-pitfalls-neuroimaging-in-headache
#20
REVIEW
Arne May
PREMISE: One of the most exciting developments in modern neuroscience was the development of imaging techniques providing a non-invasive technique for detection of structure-function relationships characteristic of pain and headache. There is no question that neuroimaging has provided us with a better understanding of how the aura in migraine develops, and it has served as a bridge between neurophysiological studies and clinical findings, although doubtless several questions remain. PEARLS: Neuroimaging drew attention toward central mechanisms in idiopathic headache syndromes...
June 2013: Cephalalgia: An International Journal of Headache
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