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https://www.readbyqxmd.com/read/29457142/cross-country-association-of-press-freedom-and-lgbt-freedom-with-prevalence-of-persons-living-with-hiv-implication-for-global-strategy-against-hiv-aids
#1
Xinguang Chen, Amy L Elliott, Shuang Wang
Background: Human behaviors are affected by attitudes and beliefs, which in turn are shaped by higher-level values to which we have ascribed. In this study, we explore the relationship between two higher-level values, press freedom and LGBT freedom, and HIV infection with national data at the population level. Methods: Data were the number of persons living with HIV (PLWH, n = 35,468,911) for 148 countries during 2011-15, press freedom index (PFI) determined by the Reporters Without Borders, and LGBT freedom index (LGBT-FI) based on laws regulating same-sex relationships and expression...
2018: Global Health Research and Policy
https://www.readbyqxmd.com/read/29456851/duodenal-mucinous-adenocarcinoma-presenting-as-ileus-obstructive-jaundice-and-massive-ascites-a-case-report
#2
Dongbing Ding, Yao Yao, Songbai Zhang
Duodenal mucinous adenocarcinoma (DMA) is a malignancy with a rather low morbidity. However, its incidence in China has not been clearly determined. We herein report a case of a 70-year-old female patient who presented with ileus, obstructive jaundice and massive ascites simultaneously. Gastroendoscopy revealed copious amounts of colloidal mucin in the gastric cavity. The neoplasm was not visualized on computed tomography or magnetic resonance imaging, and an exploratory laparotomy was performed to investigate the abdomen...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456400/unilateral-transient-watershed-cerebral-infarct-in-a-6-year-old-girl-with-frequently-relapsing-nephrotic-syndrome
#3
Kapil Bhalla, Deepali Garg, Mahima Rajan, Jaya Shankar Kaushik, Geeta Gathwala
Nephrotic syndrome is a prothrombotic state with predisposition to venous sinus thrombosis and arterial vascular stroke. Watershed infarcts in junction of arterial territory develop in hypotensive hypovolemic state. These border zone infarcts are usually bilateral in the absence of unilateral arterial stenosis or microembolism. We report a 6-year-girl of frequently relapsing nephrotic syndrome who developed sudden onset hemiparesis with aphasia. Magnetic resonance (MR) imaging brain revealed unilateral watershed infarct in territory between the major cerebral arterial vessels with evidence of restricted diffusion and normal vessel anatomy on MR angiography...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456138/the-inr-akt-torc1-growth-promoting-signaling-negatively-regulates-jak-stat-activity-and-migratory-cell-fate-during-morphogenesis
#4
Di Kang, Dou Wang, Jianbing Xu, Chao Quan, Xuan Guo, Heng Wang, Jun Luo, Zhongzhou Yang, Shuai Chen, Jiong Chen
Cell growth and cell differentiation are two distinct yet coupled developmental processes, but how they are coordinated is not well understood. During Drosophila oogenesis, we found that the growth-promoting InR/Akt/TOR pathway was involved in suppressing the fate determination of the migratory border cells. The InR/Akt/TOR pathway signals through TOR and Raptor, components of TORC1, to downregulate the JAK/STAT pathway, which is necessary and sufficient for border cell fate determination. TORC1 promotes the protein stability of SOCS36E, the conserved negative regulator of JAK/STAT signaling, through physical interaction, suggesting that TORC1 acts as a key regulator coordinating both cell growth and cell differentiation...
February 9, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29455566/-he-supported-me-100-mexican-immigrant-fathers-daughters-and-adolescent-sexual-health
#5
Kate Coleman-Minahan, Goleen Samari
OBJECTIVE: First and second generation Mexican-origin adolescents in the U.S. face social and economic disadvantage and sexual health disparities. Although fathers can support child and adolescent development, the literature has portrayed Mexican-origin immigrant fathers as emotionally distant and sexist. This study aims to treat migration as a social determinant of health to examine father-daughter relationships and adolescent sexual health in Mexican-origin immigrant families. METHODS: Integrating qualitative data from life history interviews with 21 Mexican-origin young women in immigrant families with quantitative data on first and second generation Mexican-origin young women in the National Longitudinal Study of Adolescent to Adult Health, this study describes father-daughter relationships, examines the association between father-daughter relationships and daughters' early sexual initiation, and considers the impact of migration on the father-daughter relationship and sexual health among Mexican-origin young women...
February 19, 2018: Ethnicity & Health
https://www.readbyqxmd.com/read/29455562/spatiotemporal-characteristics-of-the-hiv-1-crf02_ag-crf63_02a1-epidemic-in-russia-and-central-asia
#6
Evangelia-Georgia Kostaki, Timokratis Karamitros, Marina Bobkova, Martha Oikonomopoulou, Gkikas Magiorkinis, Federico Garcia, Angelos Hatzakis, Dimitrios Paraskevis
BACKGROUND: Eastern European countries including Russia, Ukraine and other former Soviet Union (FSU) countries have experienced an HIV epidemic spreading mostly among people who inject drugs (PWID). We aimed to investigate the origin and the dispersal patterns of HIV-1 CRF02_AG in Russia and other FSU countries. METHODS: We studied 136 CRF02_AG sequences originating from Russia, and FSU countries along with a globally sampled dataset of 3,580 CRF02_AG sequences...
February 17, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29455463/challenges-of-analyzing-the-global-trade-in-cites-listed-wildlife
#7
Janine E Robinson, Pablo Sinovas
International wildlife trade can represent a major threat to biodiversity conservation. Annually, billions of plants, animals and their products are traded across international borders, with legal trade alone estimated to be worth over 320 billion USD per annum (TRAFFIC 2009). This article is protected by copyright. All rights reserved.
February 17, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29454929/hur-mediated-scn5a-mrna-stability-reduces-arrhythmic-risk-in-heart-failure
#8
Anyu Zhou, An Xie, Tae Yun Kim, Hong Liu, Guangbin Shi, Gyeoung-Jin Kang, Ning Jiang, Man Liu, Euy-Myoung Jeong, Bum-Rak Choi, Samuel C Dudley
BACKGROUND: Downregulated sodium currents in heart failure (HF) has been linked to increased arrhythmic risk. Reduced expression of mRNA stabilizing protein ELAVL1/HuR may be responsible for the downregulation of sodium channel gene SCN5A mRNA. OBJECTIVE: To investigate whether HuR regulates SCN5A mRNA expression and whether manipulation of HuR benefits arrhythmia control in HF. METHODS: Quantitative real-time reverse-transcriptase PCR (qRT-PCR) were used to investigate the expression of SCN5A...
February 15, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29454858/expression-of-heat-shock-protein-70-and-cell-death-kinetics-after-different-thermal-impacts-on-cultured-retinal-pigment-epithelial-cells
#9
Katharina Kern, Carla-Lotta Mertineit, Ralf Brinkmann, Yoko Miura
Recent technologies are broadening the possibility to treat the retinal pigment epithelium (RPE) with different thermal impacts, from sublethal to lethal ranges. Thus temperature-dependent subcellular molecular responses need to be elucidated in more detail. In this study, RPE cell viability and expression of heat shock protein 70 (Hsp70) were investigated after thermal irradiation with different temperature increase using an in-vitro model. Primary porcine RPE cell cultures were irradiated with different laser power of a thulium laser (λ = 1940 nm, beam-diameter 30 mm) for 10 s, such that the maximal temperatures at the center of the culture dish (Tmax ) reach 40, 44, 47, 51 or 59 °C after 10s' irradiation...
February 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29454554/geospatial-inequalities-and-determinants-of-nutritional-status-among-women-and-children-in-afghanistan-an-observational-study
#10
Nadia Akseer, Zaid Bhatti, Taufiq Mashal, Sajid Soofi, Rahim Moineddin, Robert E Black, Zulfiqar A Bhutta
BACKGROUND: Undernutrition is a pervasive condition in Afghanistan, and prevalence is among the highest in the world. We aimed to comprehensively assess district-level geographical disparities and determinants of nutritional status (stunting, wasting, or underweight) among women and children in Afghanistan. METHODS: The study used individualised data from the recent Afghanistan National Nutrition Survey 2013. Outcome variables were based on growth and weight anthropometry data, which we analysed linearly as Z scores and as dichotomous categories...
February 14, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29454357/border-analysis-for-spatial-clusters
#11
Fernando L P Oliveira, André L F Cançado, Gustavo de Souza, Gladston J P Moreira, Martin Kulldorff
BACKGROUND: The spatial scan statistic is widely used by public health professionals in the detection of spatial clusters in inhomogeneous point process. The most popular version of the spatial scan statistic uses a circular-shaped scanning window. Several other variants, using other parametric or non-parametric shapes, are also available. However, none of them offer information about the uncertainty on the borders of the detected clusters. METHOD: We propose a new method to evaluate uncertainty on the boundaries of spatial clusters identified through the spatial scan statistic for Poisson data...
February 17, 2018: International Journal of Health Geographics
https://www.readbyqxmd.com/read/29454346/agrobacterium-mediated-and-electroporation-mediated-transformation-of-chlamydomonas-reinhardtii-a-comparative-study
#12
Paola Mini, Olivia Costantina Demurtas, Silvia Valentini, Patrizia Pallara, Giuseppe Aprea, Paola Ferrante, Giovanni Giuliano
BACKGROUND: Chlamydomonas reinhardtii is an unicellular green alga used for functional genomics studies and heterologous protein expression. A major hindrance in these studies is the low level and instability of expression of nuclear transgenes, due to their rearrangement and/or silencing over time. RESULTS: We constructed dedicated vectors for Agrobacterium-mediated transformation carrying, within the T-DNA borders, the Paromomycin (Paro) selectable marker and an expression cassette containing the Luciferase (Luc) reporter gene...
February 17, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29453360/role-of-intestinal-trefoil-factor-in-protecting-intestinal-epithelial-cells-from-burn-induced-injury
#13
Jianhong Hu, Yan Shi, Chao Wang, Hanxing Wan, Dan Wu, Hongyu Wang, Xi Peng
Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA and the underlying mechanisms. We found that ITF significantly stimulated intestinal glutamine transport in burned rats. Mechanistically, ITF enhanced autophagy, reduces endoplasmic reticulum stress (ERS), and alleviates the impaired PDI, ASCT2, and B0AT1 in IECs and BBMVs after burn injury likely through AMPK activation...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453040/illuminating-atom-taking-time-across-the-colour-category-border
#14
Steven Samuel, Emanuel Bylund, Rachel Cooper, Panos Athanasopoulos
Walsh's A Theory Of Magnitude (ATOM) contends that we represent magnitudes such as number, space, time and luminance on a shared metric, such that "more" of one leads to the perception of "more" of the other (e.g. Walsh, 2003). In support of ATOM, participants have been shown to judge intervals between stimuli that are more discrepant in luminance as having a longer duration than intervals between stimuli whose luminance differs by a smaller degree (Xuan, Zhang, He, & Chen, 2007). We tested the potential limits to the ability of luminance to influence duration perception by investigating the possibility that the luminance-duration relationship might be interrupted by a concurrent change in the colour of that luminance...
February 13, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29451657/malignant-fibrous-histiocytoma-in-a-patient-presenting-with-urinary-system-symptoms
#15
Mustafa Resorlu, Ozan Karatag, Fatma Uysal, Muhsin Ozturk
Malignant fibrous histiocytoma is a rare tumor. It is most commonly seen in individuals between the fifth and seventh decades of life, in extremities, and less frequently in the retroperitoneum. Although its etiology is not clearly known, radiotherapy, chemical agents, previous history of surgery, trauma and fracture, and Hodgkin lymphoma have been blamed. Leiomyosarcoma, liposarcoma and rhabdomyosarcoma should be taken into account in differential diagnosis. It is seen on computed tomography as a mass lesion with irregular borders and density similar to that of the surrounding muscle tissue...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29450630/outermost-layer-oriented-medial-approach-for-infrapyloric-nodal-dissection-in-laparoscopic-distal-gastrectomy
#16
Susumu Shibasaki, Koichi Suda, Masaya Nakauchi, Tetsuya Nakamura, Shinichi Kadoya, Kenji Kikuchi, Kazuki Inaba, Ichiro Uyama
BACKGROUND: Based on our experience of suprapancreatic nodal dissection in laparoscopic gastrectomy, we developed an outermost layer-oriented medial approach for infrapyloric nodal dissection. The objective of this single-institution retrospective study was to determine the feasibility, safety, and reproducibility of this novel and unique dissection procedure. METHODS: This approach can be performed in the same manner as suprapancreatic nodal dissection but by replacing the left gastric artery with the right gastroepiploic artery (RGEA), the common hepatic artery with the anterior superior pancreaticoduodenal artery (ASPDA), and the splenic artery with the gastroduodenal artery...
February 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29450466/diagnostic-criteria-of-ulcerative-pyoderma-gangrenosum-a-delphi-consensus-of-international-experts
#17
Emanual Maverakis, Chelsea Ma, Kanade Shinkai, David Fiorentino, Jeffrey P Callen, Uwe Wollina, Angelo Valerio Marzano, Daniel Wallach, Kyoungmi Kim, Courtney Schadt, Anthony Ormerod, Maxwell A Fung, Andrea Steel, Forum Patel, Rosie Qin, Fiona Craig, Hywel C Williams, Frank Powell, Alexander Merleev, Michelle Y Cheng
Importance: Pyoderma gangrenosum is a rare inflammatory skin condition that is difficult to diagnose. Currently, it is a "diagnosis of exclusion," a definition not compatible with clinical decision making or inclusion for clinical trials. Objective: To propose and validate diagnostic criteria for ulcerative pyoderma gangrenosum. Evidence Review: Diagnostic criteria were created following a Delphi consensus exercise using the RAND/UCLA Appropriateness Method...
February 14, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29449878/complete-chloroplast-genome-of-the-medicinal-plant-amomum-compactum-gene-organization-comparative-analysis-and-phylogenetic-relationships-within-zingiberales
#18
Ming-Li Wu, Qing Li, Jiang Xu, Xi-Wen Li
Background: Amomum compactum is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position of A. compactum is not clear yet, and the introduction of this plant has been hindered by many plant diseases. However, the correlational molecular studies are relatively scarce. Methods: The total chloroplast (cp) DNA was extracted according to previous studies, and then sequenced by 454 GS FLX Titanium platform...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449779/-saccharomyces-boulardii-cncm-i-745-improves-intestinal-enzyme-function-a-trophic-effects-review
#19
REVIEW
Margret I Moré, Yvan Vandenplas
Several properties of the probiotic medicinal yeast Saccharomyces boulardii CNCM I-745 contribute to its efficacy to prevent or treat diarrhoea. Besides immunologic effects, pathogen-binding and anti-toxin effects, as well as positive effects on the microbiota, S boulardii CNCM I-745 also has pronounced effects on digestive enzymes of the brush border membrane, known as trophic effects. The latter are the focus of this review. Literature has been reviewed after searching Medline and PMC databases. All relevant non-clinical and clinical studies are summarized...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29449684/fibroepithelial-lesions-of-the-breast-a-comprehensive-morphological-and-outcome-analysis-of-a-large-series
#20
Elzbieta Slodkowska, Sharon Nofech-Mozes, Bin Xu, Carlos Parra-Herran, Fang-I Lu, Simon Raphael, Judit Zubovits, Wedad Hanna
Mammary fibroepithelial lesions encompass a wide spectrum of tumors ranging from an indolent fibroadenoma to potentially fatal malignant phyllodes tumor. The criteria used for their classification based on morphological assessment are often challenging to apply and there is no consensus as to what constitutes an adequate resection margin. We studied a retrospective cohort of 213 fibroepithelial lesions in 178 patients (80 fibroadenomas with unusual features and 133 phyllodes tumors: 63 benign, 41 borderline, and 29 malignant) in order to describe the spectrum of changes within each group, with special emphasis on margin evaluation...
February 14, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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