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https://www.readbyqxmd.com/read/29054781/superselective-thalamotomy-in-the-most-lateral-part-of-the-ventralis-intermedius-nucleus-for-controlling-essential-and-parkinsonian-tremor
#1
Masafumi Hirato, Takaaki Miyagishima, Akio Takahashi, Yuhei Yoshimoto
OBJECTIVE: The minimum and essential thalamic areas for reducing tremor were investigated in cases treated by superselective thalamotomy in the most lateral part of ventralis intermedius nucleus (mlp-VIM). METHODS: Stereotactic superselective VIM thalamotomy with depth microrecording was performed in 21 patients with essential tremor (ET) and 15 patients with tremor-dominant Parkinson's disease (PD). A very small and narrow (axial plane) therapeutic lesion was formed as a square on the sagittal plane and inverse V on the axial plane in the mlp-VIM, which covered the kinesthetic response area topographically related to tremor...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054751/ng2-cspg4-and-progranulin-in-the-posttraumatic-glial-scar
#2
REVIEW
Michael K E Schäfer, Irmgard Tegeder
Traumatic injury of the central nervous system is one of the leading causes of death and disability in young adults. Failure of regeneration is caused by autonomous neuronal obstacles and by formation of the glial scar, which is essential to seal the injury but also constitutes a barrier for regrowing axons. The scar center is highly inflammatory and populated by NG2+ glia, whereas astrocytes form the sealing border and trap regrowing axons, suggesting that the non-permissive environment of activated astrocytes and extracellular matrix components is one of the reasons for the regenerative failure...
October 17, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29054679/cost-effectiveness-analysis-of-two-impression-methods-for-the-fabrication-of-mandibular-complete-dentures
#3
Anna Miyayasu, Manabu Kanazawa, Ayami Jo, Yusuke Sato, Shunsuke Minakuchi
OBJECTIVES: To compare the cost and to evaluate cost-effectiveness of fabricating mandibular complete dentures (CDs) using two different impression methods. METHODS: A crossover randomized controlled trial including 27 edentulous participants was performed. Mandibular CDs were fabricated using two different impression methods, as follows: (i) conventional method using a custom tray border moulded with impression compound and silicone and (ii) simplified method using a stock tray and alginate...
October 17, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29053772/the-effect-of-increased-alcohol-availability-on-alcohol-related-health-problems-up-to-the-age-of-42-among-children-exposed-in-utero-a-natural-experiment
#4
Emelie Thern, David Carslake, George Davey Smith, Per Tynelius, Finn Rasmussen
Aim: To examine whether exposure to increased alcohol availability in utero is associated with later alcohol-related health problems. Method: Register-linked population-based longitudinal study using data from a natural experiment setting, including 363 286 children born 1965-71. An experimental alcohol policy change was piloted in two regions of Sweden in 1967-68, where access to strong beer increased for 16-20 year old. Children exposed in utero to the policy change were compared to children born elsewhere in Sweden (excluding a border area), and to children born before and after the policy change...
October 19, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29053486/retrospective-analysis-of-sinus-membrane-thickening-profile-causal-factors-and-its-influence-on-complications
#5
Hyun-Chang Lim, Ji-Yeon Nam, Jae-Kook Cha, Jung-Seok Lee, Dong-Woon Lee, Ui-Won Jung, Seong-Ho Choi
PURPOSE: To retrospectively determine the profile of the sinus membrane (SM), potential factors affecting SM thickening (SMT), and the correlation between SMT and sinus augmentation (SA) complications. MATERIALS AND METHODS: In the patients who received lateral SA, SMT was classified in sagittal sections of cone-beam computed tomography according to its thickness and morphology. The correlation between SMT and the following factors was analyzed: age, sex, endodontic and periodontic statuses of neighboring teeth, and shape of the sinus inferior border...
October 17, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/29052982/designing-a-thermoelectric-copper-rich-sulfide-from-a-natural-mineral-synthetic-germanite-cu22fe8ge4s32
#6
Ventrapati Pavan Kumar, Laura Paradis-Fortin, Pierric Lemoine, Vincent Caignaert, Bernard Raveau, Bernard Malaman, Gérard Le Caër, Stéphane Cordier, Emmanuel Guilmeau
This study shows that the design of copper-rich sulfides by mimicking natural minerals allows a new germanite-type sulfide Cu22Fe8Ge4S32 with promising thermoelectric properties to be synthesized. The Mössbauer spectroscopy and X-ray diffraction analyses provide evidence that the structure of our synthetic compound differs from that of the natural germanite mineral Cu26Fe4Ge4S32 by its much higher Cu(+)/Cu(2+) ratio and different cationic occupancies. The coupled substitution Cu/Fe in the Cu26-xFe4+xGe4S32 series also appears as a promising approach to optimize the thermoelectric properties...
October 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29052767/acute-regulation-of-multidrug-resistance-associated-protein-2-localization-and-activity-by-camp-and-estradiol-17%C3%AE-d-glucuronide-in-rat-intestine-and-caco-2-cells
#7
Guillermo Nicolás Tocchetti, Agostina Arias, Maite Rocío Arana, Juan Pablo Rigalli, Camila Juliana Domínguez, Felipe Zecchinati, María Laura Ruiz, Silvina Stella Maris Villanueva, Aldo Domingo Mottino
Multidrug resistance-associated protein 2 (MRP2) is an ATP-dependent transporter expressed at the brush border membrane of the enterocyte that confers protection against absorption of toxicants from foods or bile. Acute, short-term regulation of intestinal MRP2 activity involving changes in its apical membrane localization was poorly explored. We evaluated the effects of dibutyryl-cAMP (db-cAMP), a permeable analog of cAMP, and estradiol-17β-D-glucuronide (E217G), an endogenous derivative of estradiol, on MRP2 localization and activity using isolated rat intestinal sacs and Caco-2 cells, a model of human intestinal epithelium...
October 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29051750/epidemiology-of-extended-spectrum-%C3%AE-lactamase-producing-e-coli-and-vancomycin-resistant-enterococci-in-the-northern-dutch-german-cross-border-region
#8
Xuewei Zhou, Silvia García-Cobos, Gijs J H M Ruijs, Greetje A Kampinga, Jan P Arends, Dirk M Borst, Lieke V Möller, Nicole D Holman, Theo A Schuurs, Lesla E Bruijnesteijn van Coppenraet, Jan F Weel, Jan H van Zeijl, Robin Köck, John W A Rossen, Alexander W Friedrich
Objectives: To reveal the prevalence and epidemiology of extended-spectrum β-lactamase (ESBL)- and/or plasmid AmpC (pAmpC)- and carbapenemase (CP) producing Enterobacteriaceae and vancomycin-resistant enterococci (VRE) across the Northern Dutch-German border region. Methods: A point-prevalence study on ESBL/pAmpC/CP producing Enterobacteriaceae and VRE was carried out in hospitalized patients in the Northern Netherlands (n = 445, 2012-2013) and Germany (n = 242, 2012). Healthy individuals from the Dutch community (n = 400, 2010-2012) were also screened...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29050828/quantification-of-right-ventricular-size-and-function-from-contrast-enhanced-three-dimensional-echocardiographic-images
#9
Diego Medvedofsky, Victor Mor-Avi, Eric Kruse, Brittney Guile, Boguslawa Ciszek, Lynn Weinert, Megan Yamat, Valentina Volpato, Karima Addetia, Amit R Patel, Roberto M Lang
BACKGROUND: Three-dimensional (3D) echocardiography directly assesses right ventricular (RV) volumes without geometric assumptions, despite the complex shape of the right ventricle, and accordingly is more accurate and reproducible than the two-dimensional methodology, which is able to measure only surrogate parameters of RV function. Volumetric analysis has been hampered by frequent inability to clearly visualize RV endocardium, especially the RV free wall, in 3D echocardiographic images...
October 17, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29049171/convex-border-of-peripheral-non-small-cell-lung-cancer-on-ct-images-as-a-potential-indicator-of-pleural-invasion
#10
Jui-Sheng Hsu, Twei-Shiun Jaw, Chih-Jen Yang, Shiou-Fu Lin, Ming-Chen Paul Shih, Shah-Hwa Chou, Inn-Wen Chong, Ming-Yen Lin, I-Chan Chiang
The aim of the study is to evaluate the use of the tumor border in peripheral non-small cell lung cancer (NSCLC) as an indicator of pleural invasion.This retrospective study was performed at a single tertiary center. The analysis of 136 patients with peripheral NSCLC included 101 (74.3%) patients with pathologically proven pleural invasion and 35 (25.7%) patients without pleural invasion. The tumor borders on conventional computed tomography (CT) were classified into 5 types on lung window setting: type 1, S or reverse S border with a blunt angle; type 2, sharp angle; type 3, concave border with a blunt angle; type 4, straight border with a perpendicular angle; and type 5, convex border with a perpendicular or blunt angle...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049113/the-us-opioid-crisis-current-federal-and-state-legal-issues
#11
Cobin D Soelberg, Raeford E Brown, Derick Du Vivier, John E Meyer, Banu K Ramachandran
The United States is in the midst of a devastating opioid misuse epidemic leading to over 33,000 deaths per year from both prescription and illegal opioids. Roughly half of these deaths are attributable to prescription opioids. Federal and state governments have only recently begun to grasp the magnitude of this public health crisis. In 2016, the Centers for Disease Control and Prevention released their Guidelines for Prescribing Opioids for Chronic Pain. While not comprehensive in scope, these guidelines attempt to control and regulate opioid prescribing...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29047033/characterization-of-pulmonary-nodules-based-on-features-of-margin-sharpness-and-texture
#12
José Raniery Ferreira, Marcelo Costa Oliveira, Paulo Mazzoncini de Azevedo-Marques
Lung cancer is the leading cause of cancer-related deaths in the world, and one of its manifestations occurs with the appearance of pulmonary nodules. The classification of pulmonary nodules may be a complex task to specialists due to temporal, subjective, and qualitative aspects. Therefore, it is important to integrate computational tools to the early pulmonary nodule classification process, since they have the potential to characterize objectively and quantitatively the lesions. In this context, the goal of this work is to perform the classification of pulmonary nodules based on image features of texture and margin sharpness...
October 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29047032/rethinking-skin-lesion-segmentation-in-a-convolutional-classifier
#13
Jack Burdick, Oge Marques, Janet Weinthal, Borko Furht
Melanoma is a fatal form of skin cancer when left undiagnosed. Computer-aided diagnosis systems powered by convolutional neural networks (CNNs) can improve diagnostic accuracy and save lives. CNNs have been successfully used in both skin lesion segmentation and classification. For reasons heretofore unclear, previous works have found image segmentation to be, conflictingly, both detrimental and beneficial to skin lesion classification. We investigate the effect of expanding the segmentation border to include pixels surrounding the target lesion...
October 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29046628/the-human-periallocortex-layer-pattern-in-presubiculum-parasubiculum-and-entorhinal-cortex-a-review
#14
REVIEW
Ricardo Insausti, Mónica Muñoz-López, Ana M Insausti, Emilio Artacho-Pérula
The cortical mantle is not homogeneous, so that three types of cortex can be distinguished: allocortex, periallocortex and isocortex. The main distinction among those three types is based on morphological differences, in particular the number of layers, overall organization, appearance, etc., as well as its connectivity. Additionally, in the phylogenetic scale, this classification is conserved among different mammals. The most primitive and simple cortex is the allocortex, which is characterized by the presence of three layers, with one cellular main layer; it is continued by the periallocortex, which presents six layers, although with enough differences in the layer pattern to separate three different fields: presubiculum (PrS), parasubiculum (PaS), and entorhinal cortex (EC)...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29046607/exporting-a-student-centered-curriculum-a-home-institution-s-perspective
#15
Dominique Waterval, Marjolijn Tinnemans-Adriaanse, Mohammed Meziani, Erik Driessen, Albert Scherpbier, Abdulrahman Mazrou, Janneke Frambach
Numerous, mainly Anglo-Saxon, higher education institutions have agreements with foreign providers to deliver their curricula abroad. This trend is gradually making inroads into the medical domain, where foreign institutions undertake to offer their students learning experiences similar to those of the home institution. Not an easy feat, as the national health care contexts differ greatly between institutions. In a bid to export the curriculum, institutions risk compromising their financial resilience and reputation...
July 2017: J Stud Int Educ
https://www.readbyqxmd.com/read/29046602/surveillance-at-sea-the-transactional-politics-of-border-control-in-the-aegean
#16
Huub Dijstelbloem, Rogier van Reekum, Willem Schinkel
The relationship between vision and action is a key element of both practices and conceptualizations of border surveillance in Europe. This article engages with what we call the 'operative vision' of surveillance at sea, specifically as performed by the border control apparatus in the Aegean. We analyse the political consequences of this operative vision by elaborating on three examples of fieldwork conducted in the Aegean and on the islands of Chios and Lesbos. One of the main aims is to bring the figure of the migrant back into the study of border technologies...
June 2017: Secur Dialogue
https://www.readbyqxmd.com/read/29046601/knowledge-of-practice-a-multi-sited-event-ethnography-of-border-security-fairs-in-europe-and-north-america
#17
Theodore Baird
This article takes the reader inside four border security fairs in Europe and North America to examine the knowledge practices of border security professionals. Building on the border security as practice research agenda, the analysis focuses on the production, circulation, and consumption of scarce forms of knowledge. To explore situated knowledge of border security practices, I develop an approach to multi-sited event ethnography to observe and interpret knowledge that may be hard to access at the security fairs...
June 2017: Secur Dialogue
https://www.readbyqxmd.com/read/29046055/topographic-distribution-pattern-of-morphologically-different-g-cells-in-the-murine-antral-mucosa
#18
Claudia Frick, Hanna Luisa Martin, Johanna Bruder, Kerstin Lang, Heinz Breer
Gastrin-secreting enteroendocrine cells (G cells) in the antrum play an important role in the regulation of gastric secretion, gastric motility and mucosal cell proliferation. Recently we have uncovered the existence of two subpopulations of G cells with pivotally different morphology and a distinct localization in the antral invaginations; the functional implications of the different G cell types are still elusive. In this study a transgenic mouse line in which EGFP is expressed under the control of a gastrin promoter was used to elucidate the distribution pattern of the two G cell types throughout the different regions of the antrum...
September 19, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29045706/kidney-injury-molecule-1-staining-in-renal-allograft-biopsies-10-days-after-transplantation-is-inversely-correlated-with-functioning-proximal-tubular-epithelial-cells
#19
Jonna R Bank, Pieter van der Pol, Dianne Vreeken, Catherine Monge-Chaubo, Ingeborg M Bajema, Nicole Schlagwein, Daniëlle J van Gijlswijk, Sandra W van der Kooij, Marlies E J Reinders, Johan W de Fijter, Cees van Kooten
Background: Kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are promising biomarkers for monitoring delayed graft function (DGF) after kidney transplantation. Here we investigated localization and distribution of KIM-1 and NGAL staining in renal allograft biopsies and studied their association with histological features, functional DGF (fDGF) and the tubular function slope (TFS), a functioning proximal tubular epithelial cell (PTEC) marker. Methods: Day 10 protocol biopsies of 64 donation after circulatory death recipients were stained for KIM-1 and NGAL and the positive area was quantified using ImageJ software...
October 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29045645/predictors-of-antimalarial-self-medication-in-illegal-gold-miners-in-french-guiana-a-pathway-towards-artemisinin-resistance
#20
M Douine, Y Lazrek, D Blanchet, S Pelleau, R Chanlin, F Corlin, L Hureau, B Volney, H Hiwat, S Vreden, F Djossou, M Demar, M Nacher, L Musset
Background: Malaria is endemic in French Guiana (FG), South America. Despite the decrease in cases in the local population, illegal gold miners are very affected by malaria (22.3% of them carried Plasmodium spp.). Self-medication seems to be very common, but its modalities and associated factors have not been studied. The aim of this study was to evaluate parasite susceptibility to drugs and to document behaviours that could contribute to resistance selection in illegal gold miners. Methods: This multicentric cross-sectional study was conducted in resting sites along the FG-Surinamese border...
October 17, 2017: Journal of Antimicrobial Chemotherapy
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