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https://www.readbyqxmd.com/read/28538978/the-characteristics-of-deep-optic-nerve-head-morphology-in-myopic-normal-tension-glaucoma
#1
Jong Chul Han, Eun Jung Lee, Si Bum Kim, Changwon Kee
Purpose: To investigate the relationship between axial length (AL) and deep optic nerve head (ONH) structure and to evaluate the characteristics of deep ONH structures in myopic normal tension glaucoma (NTG). Methods: The following parameters were assessed using spectral-domain optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) length, ONH tilt angle, optic canal (OC) obliqueness, and β-zone peripapillary atrophy (PPA). In addition, the angular location of the maximal value of each parameter and retinal nerve fiber layer (RNFL) defect were measured using infrared and red-free photos...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538849/-epidemiological-and-molecular-profile-of-rickettsiosis-in-peruvian-border-locations
#2
Rosa Palacios-Salvatierra, Elizabeth Anaya-Ramírez, Julio Juscamayta-López, Omar Cáceres-Rey, Leonardo Mendoza-Uribe, Patricia Mosquera-Visaloth, Fátima Conceição-Silva
Objectives.: To determine the circulation of Rickettsia in the years 2010 and 2011 in border locations in four regions ofPeru and their clinical epidemiological and molecular characteristics. Materials and Methods.: A cross-sectional study was carried out in Tumbes, Tacna, Madre de Dios, and Loreto. Whole blood samples were obtained from participants for culture and indirect immunofluorescence (IIF) testing. The DNA taken from leukocytes and ectoparasite cultures was used, and those genes detected for Rickettsia that were successfully amplified were sequenced and analyzed...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28538681/human-thalamic-somatosensory-nucleus-ventral-caudal-vc-as-a-locus-for-stimulation-by-inputs-from-tactile-noxious-and-thermal-sensors-on-an-active-prosthesis
#3
REVIEW
Jui Hong Chien, Anna Korzeniewska, Luana Colloca, Claudia Campbell, Patrick Dougherty, Frederick Lenz
The forebrain somatic sensory locus for input from sensors on the surface of an active prosthesis is an important component of the Brain Machine Interface. We now review the neuronal responses to controlled cutaneous stimuli and the sensations produced by Threshold Stimulation at Microampere current levels (TMIS) in such a locus, the human thalamic Ventral Caudal nucleus (Vc). The responses of these neurons to tactile stimuli mirror those for the corresponding class of tactile mechanoreceptor fiber in the peripheral nerve, and TMIS can evoke sensations like those produced by the stimuli that optimally activate each class...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28538449/sonographic-and-magnetic-resonance-imaging-characteristics-of-juvenile-papillomatosis-three-cases-with-different-manifestations
#4
Ravza Yilmaz, Zuhal Bayramoglu, Fuat Bicen, Arda Kayhan, Semen Yesil, Gulden Acunas
Juvenile papillomatosis (JP) is an infrequently seen benign proliferative lesion in women younger than 30 years. Herein, we present different clinical manifestations of histopathologically proven JP of the breast, in addition to magnetic resonance and sonographic imaging features of these cases. Patient 1 exhibited nipple discharge and papillary carcinoma accompanied after the operation. Patient 2 presented with a giant mass with cystic and numerous solid nodular components that filled the entire right breast...
June 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28538448/ultrasonography-for-preoperative-diagnosis-of-retroperitoneal-fibrosis
#5
Sheng-Jiang Chen, Ling Qin, Yu-Juan Xie, Jian-Ping Zhu, Qiang Zhang, Mei Chen
This study aimed to assess the application of ultrasonography for preoperative diagnosis of retroperitoneal fibrosis (RPF). A total of 51 patients with clinically suspected RPF underwent transabdominal ultrasonography and ultrasound-guided histopathologic biopsy (tAU-UGHB). Retroperitoneal fibrosis was diagnosed in 35 patients; of these, 31 cases (88.6%) received a diagnosis using tAU-UGHB. The ultrasonographic images mainly showed solid, irregular isoechoic masses, which were present behind the retroperitoneum and surrounded the abdominal aorta, inferior vena cava, and ureters and had clear borders with the encapsulated structures...
June 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28538370/radiographic-anatomical-relationship-between-spinous-process-and-pedicle-in-thoracolumbar-and-lumbar-spine
#6
Xingang Cui, Guodong Wang
Pedicle screws are widely used in spinal surgeries, but it remains technically demanding to place. There are numerous studies on the anatomy of pedicle; however, there is very little insight on the relationship between the pedicle and the spinous process, which is an important part of the spinal posterior column.The aim of the study was to investigate the radiographic anatomical relationship between spinous processes and pedicles in the thoracolumbar and lumbar spine, in order to reveal a novel entrance point for pedicle screw insertion...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28534826/atp-driven-contraction-of-phage-t3-capsids-with-dna-incompletely-packaged-in-vivo
#7
Philip Serwer, Elena T Wright
Adenosine triphosphate (ATP) cleavage powers packaging of a double-stranded DNA (dsDNA) molecule in a pre-assembled capsid of phages that include T3. Several observations constitute a challenge to the conventional view that the shell of the capsid is energetically inert during packaging. Here, we test this challenge by analyzing the in vitro effects of ATP on the shells of capsids generated by DNA packaging in vivo. These capsids retain incompletely packaged DNA (ipDNA) and are called ipDNA-capsids; the ipDNA-capsids are assumed to be products of premature genome maturation-cleavage...
May 19, 2017: Viruses
https://www.readbyqxmd.com/read/28534288/physicochemical-and-biological-characterization-of-sustained-isopropyl-unoprostone-release-device-made-of-poly-ethyleneglycol-dimethacrylates
#8
Nobuhiro Nagai, Yasuko Izumida, Yoshimasa Yamazaki, Hirokazu Kaji, Junichi Kawasaki, Matsuhiko Nishizawa, Toshiaki Abe
Transscleral drug delivery is becoming increasingly popular to manage posterior eye diseases. To evaluate the clinical application of a transscleral, sustained, unoprostone (UNO)-release device (URD) constructed of photopolymerized tri(ethyleneglycol) dimethacrylate and poly(ethyleneglycol) dimethacrylate, we evaluated physicochemical and biological properties of this device. The URD consists of a drug-impermeable reservoir and a semi-permeable cover. The in vitro release rate of UNO from the URD increased with increasing temperatures from 20 to 45 °C...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28533804/the-use-of-trans-applicator-intracavitary-ultrasonography-in-brachytherapy-for-cervical-cancer-phantom-study-of-a-novel-approach-to-3d-image-guided-brachytherapy
#9
Tomoaki Tamaki, Kazunori Miyaura, Toshihiro Murakami, Yu Kumazaki, Yoshiyuki Suzuki, Takashi Nakano, Shingo Kato
PURPOSE: To assess the feasibility of applying trans-applicator intracavitary ultrasonography to image-guided brachytherapy for cervical cancer. MATERIAL AND METHODS: For this experiment, a phantom was created and included a polyethylene tube, intended to simulate a tandem applicator, which was inserted into chicken meat and embedded in agar, along with magnetic resonance imaging (MRI)-compatible ovoid applicators. Three-dimensional images of the phantom were obtained using computed tomography (CT), MRI (T2-weighted), and intracavitary ultrasonography sectional images acquired at 1 mm slice intervals...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533794/boron-supply-enhances-aluminum-tolerance-in-root-border-cells-of-pea-pisum-sativum-by-interacting-with-cell-wall-pectins
#10
Xue Wen Li, Jia You Liu, Jing Fang, Lin Tao, Ren Fang Shen, Ya Lin Li, Hong Dong Xiao, Ying Ming Feng, Hai Xiang Wen, Jia Hua Guan, Li Shu Wu, Yong Ming He, Heiner E Goldbach, Min Yu
Aluminum (Al) toxicity is the primary factor limiting crop growth in acidic soils. Boron (B) alleviates Al toxicity in plants, which is mainly considered to be due to the formation of Rhamnogalacturonan II-B (RGII-B) complexes, which helps to stabilize the cytoskeleton. It is unclear yet whether this is due to the increasing of net negative charges and/or further mechanisms. Kinetics of Al accumulation and adsorption were investigated using entire cells, cell wall and pectin of root border cells (RBCs) of pea (Pisum sativum), to reveal the mechanism of B in interacting with alkali-soluble and chelator-soluble pectin for an increased Al tolerance in RBCs...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28533409/inducible-ctcf-insulator-delays-the-igh-3-regulatory-region-mediated-activation-of-germline-promoters-and-alters-class-switching
#11
Fatima-Zohra Braikia, Chloé Oudinet, Dania Haddad, Zeliha Oruc, Domenico Orlando, Audrey Dauba, Marc Le Bert, Ahmed Amine Khamlichi
Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to switch from IgM expression to the expression of downstream isotypes. CSR is preceded by inducible germline (GL) transcription of the constant genes and is controlled by the 3' regulatory region (3'RR) in a stimulus-dependent manner. Why the 3'RR-mediated up-regulation of GL transcription is delayed to the mature B-cell stage is presently unknown. Here we show that mice devoid of an inducible CTCF binding element, located in the α constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR in activated B cells...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28532911/lateral-transpsoas-approach-to-the-lumbar-spine-and-relationship-of-the-ureter-anatomical-study-with-application-to-minimizing-complications
#12
Vlad Voin, Christina Kirkpatrick, Fernando Alonso, Tarush Rastugi, Filipe H Sanders, Doniel Drazin, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: Complications from lateral lumbar interbody fusion procedures range from neurological deficits to organs and blood vessel to injuries. Injury to the ureter has been reported though uncommon. The present study was performed to elucidate the anatomical relationship of the ureter to this surgical approach. METHODS: Eight adult cadavers (16 sides) were placed in the full lateral position and the distal ureter cannulated with a metal wire, which was passed up to the kidney...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28532032/agar-gelatin-bilayer-gel-matrix-fabricated-by-simple-thermo-responsive-sol-gel-transition-method
#13
Yifeng Wang, Meng Dong, Mengmeng Guo, Xia Wang, Jing Zhou, Jian Lei, Chuanhang Guo, Chaoran Qin
We present a simple and environmentally-friendly method to generate an agar/gelatin bilayer gel matrix for further biomedical applications. In this method, the thermally responsive sol-gel transitions of agar and gelatin combined with the different transition temperatures are exquisitely employed to fabricate the agar/gelatin bilayer gel matrix and achieve separate loading for various materials (e.g., drugs, fluorescent materials, and nanoparticles). Importantly, the resulting bilayer gel matrix provides two different biopolymer environments (a polysaccharide environment vs a protein environment) with a well-defined border, which allows the loaded materials in different layers to retain their original properties (e...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531285/paratrigeminal-paraclival-precavernous-or-all-of-the-above-a-circumferential-anatomical-study-of-the-c3-c4-transitional-segment-of-the-internal-carotid-artery
#14
Eleonora Marcati, Norberto Andaluz, Sebastien C Froelich, Lee A Zimmer, James L Leach, Juan Carlos Fernandez-Miranda, Almaz Kurbanov, Jeffrey T Keller
BACKGROUND: Although the term paraclival carotid pervades recent skull base literature, no clear consensus exists regarding boundaries or anatomical segments. OBJECTIVE: To reconcile various internal carotid artery (ICA) nomenclatures for transcranial and endoscopic-endonasal perspectives, we reexamined the transition between lacerum (C3) and cavernous (C4) segments using a C1-C7 segments schema. In this cadaveric study, we obtained a 360°-circumferential view integrating histological, microsurgical, endoscopic, and neuroradiological analyses of this C3-C4 region and identified a distinct transitional segment...
May 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28531196/co-inheritance-of-glucose-6-phosphate-dehydrogenase-deficiency-mutations-and-hemoglobin-e-in-a-kachin-population-in-a-malaria-endemic-region-of-southeast-asia
#15
Zeshuai Deng, Fang Yang, Yao Bai, Lijun He, Qing Li, Yanrui Wu, Lan Luo, Hong Li, Limei Ma, Zhaoqing Yang, Yongshu He, Liwang Cui
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and hemoglobin E (HbE, β26 Glu-Lys) are two common red cell disorders in Southeast Asia. G6PD deficiency produces hemolytic anemia, which can be triggered by certain drugs or infections. HbE is asymptomatic or is manifested as microcytic, minimally hemolytic anemia. The association between G6PD deficiency and HbE is little understood. This study aimed to investigate G6PD deficiency and HbE in a Kachin ethnic group in the China-Myanmar border area. G6PD enzyme activity was measured using a quantitative G6PD assay, G6PD variants genotyped by the SNaPshot assay, and an HbE gene mutation identified by an amplification refractory mutation system and subsequently confirmed by using a reverse dot blot hybridization assay from 100 unrelated individuals in the study area...
2017: PloS One
https://www.readbyqxmd.com/read/28530845/temporal-variation-in-the-abundance-and-timing-of-daily-activity-of-chagas-disease-vector-triatoma-gerstaeckeri-st%C3%A3-l-1859-in-a-natural-habitat-in-the-lower-rio-grande-valley-south-texas
#16
Alfredo Flores, Christopher Vitek, Teresa Feria Arroyo, Brian Lund Fredensborg
Chagas disease caused by Trypanosoma cruzi is a burden to millions of people in South and Central America. A sylvatic life cycle of the parasite exists in the Southern United States, but recent studies indicate an active peri-domestic life cycle of T. cruzi in Texas. The USA-Mexico border region in Texas displays areas of high poverty and sub-standard housing conditions which are important risk factors for a potential spill-over transmission to a domestic life cycle including humans. The objectives of the study were to examine short- and longterm temporal variation in vector activity, and to evaluate the effect of different combinations of attractants on the capture of potential triatomine vectors...
May 22, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28530509/genotyping-toxoplasma-gondii-with-the-b1-gene-in-naturally-infected-sheep-from-an-endemic-region-in-the-pacific-coast-of-mexico
#17
Williams Arony Martínez-Flores, José Manuel Palma-García, Heriberto Caballero-Ortega, Alejandra Del Viento-Camacho, Eduardo López-Escamilla, Fernando Martínez-Hernández, Pablo Vinuesa, Dolores Correa, Pablo Maravilla
Toxoplasma gondii is a protozoan parasite with a broad ecological valence, which has been detected in a wide range of hosts and landscapes. Although the genus is considered monospecific, in recent years it has been demonstrated to exhibit more genetic variability than previously known. In Mexico, there are few genotyping studies, which suggest that classical, autochthonous, and atypical strains are circulating. The goal of this study was to describe T. gondii genetic diversity in naturally infected sheep from Colima, Mexico...
May 22, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28530251/impact-of-resection-margin-status-on-oncological-outcomes-after-co2-laser-cordectomy
#18
P Aluffi Valletti, F Taranto, A Chiesa, F Pia, G Valente
The management of positive resection margins in micro-endoscopic glottic laser surgery remains a controversial and critical point. This study aims to assess the impact of margin status after transoral laser surgery on local control, survival and organ preservation rates; the decision- making process and treatment options in cases with positive margins are also discussed. We retrospectively reviewed the clinical and histological records of 308 consecutive patients with primary early glottic carcinoma (T1a, T1b, selected T2) and treated with endoscopic laser cordectomy...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28529708/yellow-fever-in-the-americas-the-growing-concern-about-new-epidemics
#19
Yeimer Ortiz-Martínez, Andrés Mauricio Patiño-Barbosa, Alfonso J Rodriguez-Morales
Yellow fever (YF) is a haemorrhagic viral disease with a high case fatality rate. It is considered a reemerging infectious disease of remarkable importance. During the last outbreaks in Brazil (2016-2017), many cases of YF emerged despite high YF vaccination coverage in some areas. However, there are many areas and populations worldwide where vaccination coverage has been low for years (e.g. Nigeria), which increases the risk of major epidemics in such areas, as would be the case in many of the American territories...
2017: F1000Research
https://www.readbyqxmd.com/read/28528391/dynamism-in-the-upstream-invasion-edge-of-a-freshwater-fish-exposes-range-boundary-constraints
#20
Erika S Rubenson, Julian D Olden
Studying the dynamics of species' borders can provide insight into the mechanisms limiting or promoting range expansion in response to environmental change. In the John Day River, Oregon (USA), rising stream temperatures are facilitating the upstream expansion of invasive smallmouth bass Micropterus dolomieu. Here, where smallmouth bass occupy the upstream limit of its thermal tolerance, we explore population structure and seasonal movement patterns to elucidate the environmental conditions and individual traits that define front edge (where individuals reside year-round) and leading edge (where individuals colonize, but may not establish) limits to its upstream distribution...
May 20, 2017: Oecologia
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