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https://www.readbyqxmd.com/read/27926668/brief-report-interpersonal-and-intrapersonal-factors-as-parallel-independent-mediators-in-the-association-between-internalized-hiv-stigma-and-art-adherence
#1
Victoria C Seghatol-Eslami, Heather E Dark, James L Raper, Michael J Mugavero, Janet M Turan, Bulent Turan
INTRODUCTION: People living with HIV (PLWH) need to adhere to antiretroviral therapy (ART) to achieve optimal health. One reason for ART nonadherence is HIV-related stigma. OBJECTIVES: We aimed to examine whether HIV treatment self-efficacy (an intrapersonal mechanism) mediates the stigma-adherence association. We also examined whether self-efficacy and the concern about being seen while taking HIV medication (an interpersonal mechanism) are parallel mediators independent of each other...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27925867/psychosocial-stressors-and-alcohol-use-severity-and-treatment-receipt-across-hiv-status-in-a-nationally-representative-sample-of-u-s-residents
#2
Emily C Williams, Young Sun Joo, Lauren Lipira, Joseph E Glass
BACKGROUND: Human Immunodeficiency Virus (HIV) is stigmatized and disproportionately impacts vulnerable populations. Thus people living with HIV (PLWH) may have greater exposure to psychosocial stressors than those without HIV. Exposure to psychosocial stressors may increase alcohol use and serve as barriers to alcohol treatment receipt. We evaluate whether psychosocial stressors, and alcohol use, symptom severity, and treatment receipt vary across HIV status in a general population sample of U...
December 7, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27925609/a-comparison-of-virological-suppression-and-rebound-between-indigenous-and-non-indigenous-persons-initiating-combination-antiretroviral-therapy-in-a-multisite-cohort-of-individuals-living-with-hiv-in-canada
#3
Anita C Benoit, Jaime Younger, Kerrigan Beaver, Randy Jackson, Mona Loutfy, Renée Masching, Tony Nobis, Earl Nowgesic, Doe O'Brien-Teengs, Wanda Whitebird, Art Zoccole, Mark Hull, Denise Jaworsky, Anita Rachlis, Sean Rourke, Ann N Burchell, Curtis Cooper, Robert Hogg, Marina B Klein, Nima Machouf, Julio Montaner, Chris Tsoukas, Janet Raboud, Building Bridges
BACKGROUND: This study compared time to virologic suppression and rebound between Indigenous and non-Indigenous individuals living with HIV in Canada initiating combination antiretroviral therapy (cART). METHODS: Data were from the Canadian Observational Cohort collaboration; 8 studies of treatment-naïve persons with HIV initiating cART after 1/1/2000. Fine and Gray models were used to estimate the effect of ethnicity on 1) time to virologic suppression (two consecutive viral loads (VLs) <50 copies/mL at least three months apart) after adjusting for the competing risk of death and 2) time until virologic rebound (two consecutive VLs >200 copies/mL at least three months apart) following suppression...
December 7, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27925487/a-novel-safer-conception-counseling-toolkit-for-the-prevention-of-hiv-a-mixed-methods-evaluation-in-kisumu-kenya
#4
Joelle Brown, Betty Njoroge, Eliud Akama, Brooke Breitnauer, Anna Leddy, Lynae Darbes, Richard Omondi, Okeoma Mmeje
Safer conception strategies can prevent HIV transmission between HIV-discordant partners while allowing them to conceive. However, HIV care providers in sub-Saharan Africa report they are not trained in safer conception, and patients are not routinely offered safer conception services. This mixed-methods pilot study evaluated the impact, acceptability, and feasibility of a novel Safer Conception Counseling Toolkit among providers and patients in Kenya. We enrolled 20 HIV-positive women, 10 HIV-discordant couples, and 10 providers from HIV care and treatment clinics...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27925484/risk-factors-associated-with-repeated-hiv-testing-among-internet-using-men-who-have-sex-with-men
#5
Brent A Johnson, Jennie McKenney, Alexandra V Ricca, Eli S Rosenberg, Chang Liu, Akshay Sharma, Patrick S Sullivan
: Men who have sex with men (MSM) represent a disproportionately impacted risk group for HIV incidence among at-risk U.S. POPULATIONS: Few studies have identified risk factors associated with HIV testing frequency both within and outside of traditional health care settings. MSM enrolled in a prospective cohort were mailed at-home specimen collection kits and followed for a year. Incidence density rate ratios (IDRR) of testing were calculated, and generalized estimating equations were used to analyze the association between HIV testing and behavioral factors...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27925409/more-improvement-than-progression-of-liver-fibrosis-following-antiretroviral-therapy-in-a-longitudinal-cohort-of-hiv-infected-patients-with-or-without-hbv-and-hcv-co-infections
#6
Yingying Ding, Song Duan, Runhua Ye, Yuecheng Yang, Shitang Yao, Jibao Wang, Dongdong Cao, Xing Liu, Lin Lu, Manhong Jia, Zunyou Wu, Na He
We examined the effect of combination antiretroviral therapy (cART) on liver fibrosis among HIV-infected patients with or without Hepatitis B (HBV) or C virus (HCV) co-infection. This was a retrospective cohort study of HIV-infected patients receiving cART during 2004-2016. Liver fibrosis was assessed using Fibrosis-4 (FIB-4) score with 3 classifications: Class 1, < 1.45; Class 2, 1.45-3.25; Class 3, > 3.25. Of 3,900 participants, 68.6% were HIV mono-infected, 5.3% were HIV/HBV co-infected, 23.8% were HIV/HCV co-infected and 2...
December 7, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27925407/population-level-decline-in-bmi-and-systolic-blood-pressure-following-mass-hiv-treatment-evidence-from-rural-kwazulu-natal
#7
Pascal Geldsetzer, Andrea B Feigl, Frank Tanser, Dickman Gareta, Deenan Pillay, Till Bärnighausen
OBJECTIVE: Clinic-based studies have shown that patients with human immunodeficiency virus (HIV) gain weight after initiation of antiretroviral therapy (ART). This study aimed to determine whether the scale-up of ART was associated with a population-level increase in body mass index (BMI) and blood pressure (BP) in a community with high HIV and obesity prevalence. METHODS: A household survey was conducted in rural KwaZulu-Natal before ART scale-up (in 2004) and when ART coverage had reached 25% (in 2010)...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925386/interferon-free-therapies-for-patients-with-chronic%C3%A2-hepatitis-c-genotype-3-infection-a-systematic-review
#8
Vicente Gimeno-Ballester, María Buti, Ramón San Miguel, Mar Riveiro, Rafael Esteban
INTRODUCTION: Treatment of hepatitis C virus (HCV) infection with genotype 3 remains a challenge. The HCV elimination rate with direct acting antivirals (DAAs) is lower than the values reported for other HCV genotypes. In addition, genotype 3 infected patients have a higher risk of disease progression and hepatocellular carcinoma. The aim of this study was to review the relevant literature concerning treatment of HCV genotype 3 patients with interferon-free regimens. MATERIAL AND METHODS: A literature search was conducted in the PubMed/Medline, Embase, and Web of Science electronic databases...
December 7, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27925346/hepatitis-c-infection-and-other-drug-related-harms-among-inpatients-who-injected-drugs-in-turkey
#9
Arash Alaei, Kamiar Alaei, Katherine Waye, Melissa Tracy, Marine Nalbandyan, Elif Mutlu, Mustafa Kemal Cetin
Hepatitis C Virus (HCV) is easily spread among those who share drug injection equipment. Due to the ease of contraction and growing prevalence of HCV in Eastern Europe, the aims of this study focused on describing risky injection practices as well as the prevalence of HCV, HIV, and Hepatitis B Virus (HBV) among people who inject drugs (PWID) that were admitted to public and private drug treatment centers in Turkey from 2012 to 2013. Other aims included identifying correlates of needle sharing and HCV infection...
December 7, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27925025/initiatives-to-challenge-patent-barriers-and-their-relationship-with-the-price-of-medicines-procured-by-the-brazilian-unified-national-health-system
#10
Carolinne Thays Scopel, Gabriela Costa Chaves
Since 1996, when antiretroviral (ARV) treatments started being guaranteed to people living with HIV in Brazil, the government has faced the challenge of ensuring sustainability of this policy within a context of incorporating patented medicines. This article sought to analyze the historical series of the price of lopinavir/ritonavir (LPV/r) in Brazil and in the international market also considering the initiatives to challenge patent barriers between 2001 and 2012. The methods used were mapping initiatives to challenge LPV/r patent barriers and the analysis of historical series of its price in Brazil and in the international market...
December 1, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27924779/hepatic-safety-of-maraviroc-in-patients-with-hiv-1-and-hepatitis-c-and-or-b-virus-144-week-results-from-a-randomized-placebo-controlled-trial
#11
Juergen K Rockstroh, Frank Plonski, Meena Bansal, Gerd Fätkenheuer, Catherine B Small, David M Asmuth, Gilles Pialoux, Rebecca Zhang-Roper, Ronnie Wang, Juan A Pineda, Jayvant Heera
BACKGROUND: In the primary 48-week analysis of a hepatic safety trial in patients with HIV-1 co-infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), maraviroc-containing treatment regimens were not associated with increased hepatotoxicity. METHODS: In this randomised, double-blind, placebo-controlled, multicentre study, patients received maraviroc twice daily (n=70) or placebo (n=67) with concomitant antiretroviral therapy for 144 weeks (clinicaltrials...
December 7, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27924741/health-and-health-related-indicators-in-slum-rural-and-urban-communities-a-comparative-analysis
#12
Blessing U Mberu, Tilahun Nigatu Haregu, Catherine Kyobutungi, Alex C Ezeh
BACKGROUND: It is generally assumed that urban slum residents have worse health status when compared with other urban populations, but better health status than their rural counterparts. This belief/assumption is often because of their physical proximity and assumed better access to health care services in urban areas. However, a few recent studies have cast doubt on this belief. Whether slum dwellers are better off, similar to, or worse off as compared with rural and other urban populations remain poorly understood as indicators for slum dwellers are generally hidden in urban averages...
2016: Global Health Action
https://www.readbyqxmd.com/read/27924462/fidelity-moderates-the-association-between-negative-condom-attitudes-and-outcome-behavior-in-an-evidence-based-sexual-risk-reduction-intervention-for-female-sex-workers
#13
Eileen V Pitpitan, Claudia V Chavarin, Shirley J Semple, Doroteo Mendoza, Carlos Magis Rodriguez, Hugo Staines, Gregory A Aarons, Thomas L Patterson
BACKGROUND: Intervention fidelity and participant-level variables, such as negative attitudes towards condoms, are important variables to consider in the successful implementation of evidence-based HIV prevention interventions. Mujer Segura is an intervention that has been shown to be efficacious at reducing condomless sex for female sex workers (FSWs) in Mexico [1]. PURPOSE: We examined main effects of fidelity, negative condom attitudes, and their interaction on the effectiveness of the Mujer Segura intervention at reducing condomless sex at intervention follow-up...
December 6, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27923946/prevalence-of-antiretroviral-drug-resistance-in-patients-who-are-not-responding-to-protease-inhibitor-based-treatment-results-from-the-first-national-survey-in-south-africa
#14
K Steegen, M Bronze, M A Papathanasopoulos, G van Zyl, D Goedhals, C Van Vuuren, W Macleod, I Sanne, W S Stevens, S C Carmona
Limited data exist on human immunodeficiency virus type 1 (HIV-1) resistance in patients who are not responding to protease inhibitor (PI)-based regimens in resource-limited settings. This study assessed resistance profiles in adults across South Africa who were not responding to PI-based regimens. pol sequencing was undertaken and submitted to the Stanford HIV Drug Resistance Database. At least 1 major PI mutation was detected in 16.4% of 350 participants. A total of 53.4% showed intermediate resistance to darunavir/ritonavir, whereas high-level resistance was not observed...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27923769/recombination-in-hepatitis-c-virus-is-not-uncommon-among-people-who-inject-drugs-in-kolkata-india
#15
Debanjali Gupta, Kallol Saha, Aritra Biswas, Rushna Firdaus, Monika Ghosh, Provash Chandra Sadhukhan
Recombination in RNA virus is a rare event in the survival and evolution to evade host immune system. This is increasing within high risk group population (HRG) due to super infection that occurs by continuous sharing of common drug equipment by HCV infected or HIV-HCV co-infected recurrent drug users. Recombination causes impediment to vaccine development and therapeutic intervention as standard HCV treatment is still genotype specific. Blood samples of 194 people who inject drugs (PWID) were collected from an Opioid Substitution Therapy Centre in Kolkata,India...
December 3, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27923016/development-of-a-national-campaign-addressing-south-african-men-s-fears-about-hiv-counseling-and-testing-and-antiretroviral-treatment
#16
Neil Orr, Helen Hajiyiannis, Laura Myers, Mzamani Benjamin Makhubele, Tselisehang Matekane, Richard Delate, Lusanda Mahlasela, Brenda Goldblatt
INTRODUCTION: South African men are less likely to get tested for HIV than women and are more likely to commence antiretroviral treatment (ART) at later stages of disease, default on treatment, and to die from AIDS compared with women. The purpose of this study was to conduct formative research into the ideational and behavioral factors that enable or create obstacles to mens' uptake of HIV counseling and testing (HCT) and ART. The study consulted men with a goal of developing a communication campaign aimed at improving the uptake of HIV testing and ART initiation among men...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27923014/potential-impact-of-integrated-stigma-mitigation-interventions-in-improving-hiv-aids-service-delivery-and-uptake-for-key-populations-in-senegal
#17
Carrie E Lyons, Sosthenes Ketende, Daouda Diouf, Fatou M Drame, Benjamin Liestman, Karleen Coly, Cheikh Ndour, Gnilane Turpin, Souleymane Mboup, Karim Diop, Coumba Toure-Kane, Delivette Castor, Nafissatou Leye-Diouf, Stefan Baral
BACKGROUND: Men who have sex with men (MSM) and female sex workers (FSW) are consistently shown to have a higher burden of HIV compared with other adults in Senegal. This study, HIV Prevention 2.0, evaluates the impact of the 3-tiered integrated stigma mitigation interventions (ISMIs) approach to optimizing HIV service delivery for key populations in Senegal. METHODS: Baseline assessment includes a questionnaire and biological testing for HIV. A proportion of participants enrolled into a 24-month longitudinal cohort with questionnaires and biological testing every 3 months...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27923012/using-mhealth-for-hiv-tb-treatment-support-in-lesotho-enhancing-patient-provider-communication-in-the-start-study
#18
Yael Hirsch-Moverman, Amrita Daftary, Katharine A Yuengling, Suzue Saito, Moeketsi Ntoane, Koen Frederix, Llang B Maama, Andrea A Howard
BACKGROUND: mHealth is a promising means of supporting adherence to treatment. The Start TB patients on ART and Retain on Treatment (START) study included real-time adherence support using short-text messaging service (SMS) text messaging and trained village health workers (VHWs). We describe the use and acceptability of mHealth by patients with HIV/tuberculosis and health care providers. METHODS: Patients and treatment supporters received automated, coded medication and appointment reminders at their preferred time and frequency, using their own phones, and $3...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27923009/counseling-framework-for-hiv-serodiscordant-couples-on-the-integrated-use-of-antiretroviral-therapy-and-pre-exposure-prophylaxis-for-hiv-prevention
#19
Jennifer F Morton, Connie Celum, John Njoroge, Agnes Nakyanzi, Imeldah Wakhungu, Edna Tindimwebwa, Snaidah Ongachi, Eric Sedah, Emmanuel Okwero, Kenneth Ngure, Josephine Odoyo, Nulu Bulya, Jessica E Haberer, Jared M Baeten, Renee Heffron
BACKGROUND: For HIV-serodiscordant couples, integrated delivery of antiretroviral therapy (ART) for HIV-positive partners and time-limited pre-exposure prophylaxis (PrEP) for negative partners virtually eliminates HIV transmission. Standardized messaging, sensitive to the barriers and motivators to HIV treatment and prevention, is needed for widespread scale-up of this approach. METHODS: Within the Partners Demonstration Project, a prospective interventional project among 1013 serodiscordant couples in Kenya and Uganda, we offered ART to eligible HIV-positive partners and PrEP to HIV-negative partners before ART initiation and through the HIV-positive partner's first 6 months of ART use...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27923008/a-framework-for-health-communication-across-the-hiv-treatment-continuum
#20
Stella Babalola, Lynn M Van Lith, Elizabeth C Mallalieu, Zoe R Packman, Emily Myers, Kim Seifert Ahanda, Emily Harris, Tilly Gurman, Maria-Elena Figueroa
BACKGROUND: As test and treat rolls out, effective interventions are needed to address the determinants of outcomes across the HIV treatment continuum and ensure that people infected with HIV are promptly tested, initiate treatment early, adhere to treatment, and are virally suppressed. Communication approaches offer viable options for promoting relevant behaviors across the continuum. CONCEPTUAL FRAMEWORK: This article introduces a conceptual framework, which can guide the development of effective health communication interventions and activities that aim to impact behaviors across the HIV treatment continuum in low- and medium-income countries...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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