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https://www.readbyqxmd.com/read/29651131/low-level-mitochondrial-heteroplasmy-modulates-dna-replication-glucose-metabolism-and-lifespan-in-mice
#1
Misa Hirose, Paul Schilf, Yask Gupta, Kim Zarse, Axel Künstner, Anke Fähnrich, Hauke Busch, Junping Yin, Marvin N Wright, Andreas Ziegler, Marie Vallier, Meriem Belheouane, John F Baines, Diethard Tautz, Kornelia Johann, Rebecca Oelkrug, Jens Mittag, Hendrik Lehnert, Alaa Othman, Olaf Jöhren, Markus Schwaninger, Cornelia Prehn, Jerzy Adamski, Kensuke Shima, Jan Rupp, Robert Häsler, Georg Fuellen, Rüdiger Köhling, Michael Ristow, Saleh M Ibrahim
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally arising heteroplasmy have not been experimentally studied to date. We hence generated a conplastic mouse strain carrying the mitochondrial genome of an AKR/J mouse strain (B6-mtAKR ) in a C57BL/6 J nuclear genomic background, leading to >20% heteroplasmy in the origin of light-strand DNA replication (OriL)...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643999/sympatho-adrenergic-activation-by-endurance-exercise-effect-on-metanephrines-spillover-and-its-role-in-predicting-athlete-s-performance
#2
Elisa Danese, Cantor Tarperi, Gian Luca Salvagno, Alessandra Guzzo, Fabian Sanchis-Gomar, Luca Festa, Luciano Bertinato, Martina Montagnana, Federico Schena, Giuseppe Lippi
Background: The sympatho-adrenergic activation during exercise is implicated in many cardiovascular respiratory and metabolic adaptations which have been thought to partially explain the different levels of performance observed between trained and untrained subjects. To date, no evidence exists about the association between competition performance and markers of "acute stress response". We designed this study to investigate; (i) the acute sympatho-adrenergic activation during endurance exercise in recreational runners by measuring plasma levels of free metanephrine (MN) and normethanephrine (NMN) before and after a half-marathon run; (ii) the association between the metanephrines levels and the running time...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29643814/impact-of-short-term-training-camp-on-aortic-blood-pressure-in-collegiate-endurance-runners
#3
Tsubasa Tomoto, Jun Sugawara, Ai Hirasawa, Tomoko Imai, Seiji Maeda, Shigehiko Ogoh
To investigate the influence of short-term vigorous endurance training on aortic blood pressure (BP), pulse wave analysis was performed in 36 highly trained elite collegiate endurance runners before and after a 7-day intense training camp. Subjects participated three training sessions per day, which mainly consisted of long distance running and sprint training to reach the daily target distance of 26 km. After the camp, they were divided into two groups based on whether the target training was achieved. Aortic systolic BP, pulse pressure, and tension-time index (TTI, a surrogate index of the myocardial oxygen demand) were significantly elevated after the camp in the accomplished group but not in the unaccomplished group, whereas the brachial BP remained unchanged in both groups...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29618981/influence-of-endurance-training-during-childhood-on-total-hemoglobin-mass
#4
Nicole Prommer, Nadine Wachsmuth, Ina Thieme, Christian Wachsmuth, Erica M Mancera-Soto, Andreas Hohmann, Walter F J Schmidt
Elite endurance athletes are characterized by markedly increased hemoglobin mass (Hbmass). It has been hypothesized that this adaptation may occur as a response to training at a very young age. Therefore, the aim of this study was to monitor changes in Hbmass in children aged 8-14 years following systematic endurance training. In the first study, Hbmass, VO2max, and lean body mass (LBM) were measured in 17 endurance-trained children (13 boys and 4 girls; aged 9.7 ± 1.3 years; training history 1.5±1.8 years; training volume 3...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29603120/analysis-of-sports-relevant-polymorphisms-in-a-large-brazilian-cohort-of-top-level-athletes
#5
João Paulo Limongi França Guilherme, Rômulo Bertuzzi, Adriano Eduardo Lima-Silva, Alexandre da Costa Pereira, Antonio Herbert Lancha Junior
In recent years, there have been an increasing number of genetic variants associated with athletic phenotypes. Here, we selected a set of sports-relevant polymorphisms that have been previously suggested as genetic markers for human physical performance, and we examined their association with athletic status in a large cohort of Brazilians. We evaluated a sample of 1,622 individuals, in which 966 were nonathletes, and 656 were athletes: 328 endurance athletes and 328 power athletes. Only the AGT M268T minor allele was nominally associated with the endurance status...
March 30, 2018: Annals of Human Genetics
https://www.readbyqxmd.com/read/29600149/facile-chemical-routes-to-mesoporous-silver-substrates-for-sers-analysis
#6
Elina A Tastekova, Alexander Yu Polyakov, Anastasia E Goldt, Alexander V Sidorov, Alexandra A Oshmyanskaya, Irina V Sukhorukova, Dmitry V Shtansky, Wolgang Grünert, Anastasia V Grigorieva
Mesoporous silver nanoparticles were easily synthesized through the bulk reduction of crystalline silver(I) oxide and used for the preparation of highly porous surface-enhanced Raman scattering (SERS)-active substrates. An analogous procedure was successfully performed for the production of mesoporous silver films by chemical reduction of oxidized silver films. The sponge-like silver blocks with high surface area and the in-situ-prepared mesoporous silver films are efficient as both analyte adsorbents and Raman signal enhancement mediators...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29599872/responsiveness-of-the-countermovement-jump-and-handgrip-strength-to-an-incremental-running-test-in-endurance-athletes-influence-of-sex
#7
Felipe García-Pinillos, Pedro Delgado-Floody, Cristian Martínez-Salazar, Pedro Á Latorre-Román
The present study analyzed the acute effects of an incremental running test on countermovement jump (CMJ) and handgrip strength performance in endurance athletes, considering the effect of post-exercise recovery time and sex. Thirty-three recreationally trained long-distance runners, 20 men and 13 women, participated voluntarily in this study. The participants performed the Léger test, moreover, the CMJ and handgrip strength tests were carried out before and after the running test and during different stages of recovery (at the 1st min of recovery (posttest1), 5th min of recovery (posttest2), and 10th min of recovery (posttest3))...
March 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29599725/validity-and-reliability-of-10-hz-global-positioning-system-to-assess-in-line-movement-and-change-of-direction
#8
Pantelis T Nikolaidis, Filipe M Clemente, Cornelis M I van der Linden, Thomas Rosemann, Beat Knechtle
The objectives of the present study were to examine the validity and reliability of the 10 Hz Johan GPS unit in assessing in-line movement and change of direction. The validity was tested against the criterion measure of 200 m track-and-field (track-and-field athletes, n = 8) and 20 m shuttle run endurance test (female soccer players, n = 20). Intra-unit and inter-unit reliability was tested by intra-class correlation coefficient (ICC) and coefficient of variation (CV), respectively. An analysis of variance examined differences between the GPS measurement and five laps of 200 m at 15 km/h, and t -test examined differences between the GPS measurement and 20 m shuttle run endurance test...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29590340/exercise-cardiac-magnetic-resonance-to-differentiate-athlete-s-heart-from-structural-heart-disease
#9
Guido Claessen, Frédéric Schnell, Jan Bogaert, Mathias Claeys, Nele Pattyn, Frederik De Buck, Steven Dymarkowski, Piet Claus, Francois Carré, Johan Van Cleemput, Andre La Gerche, Hein Heidbuchel
Aims: The distinction between left ventricular (LV) dilation with mildly reduced LV ejection fraction (EF) in response to regular endurance exercise training and an early cardiomyopathy is a frequently encountered and difficult clinical conundrum. We hypothesized that exercise rather than resting measures would provide better discrimination between physiological and pathological LV remodelling and that preserved exercise capacity does not exclude significant LV damage. Methods and results: We prospectively included 19 subjects with LVEF between 40 and 52%, comprising 10 ostensibly healthy endurance athletes (EA-healthy) and nine patients with dilated cardiomyopathy (DCM)...
March 26, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29581653/effects-of-mechanical-bed-massage-on-exercise-induced-back-fatigue-in-athletes
#10
Houyong Zhong, Wichai Eungpinichpong, Xingze Wang, Uraiwon Chatchawan, Sawitri Wanpen, Orawan Buranruk
[Purpose] The study aimed to preliminarily investigate the effects of mechanical-bed massage on exercise-induced back fatigue in athletes. [Subjects and Methods] Twelve male college athletes, randomly allocated to experimental or control groups, were instructed to perform reverse sit-up for 8 sessions until they became fatigued. The experimental group received a 20-min mechanical-bed massage session, while the control group rested on a bed for the same period of time. Visual Analogue Scale (VAS) on perceived back muscle fatigue, back muscle endurance, and Heart Rate Variability (HRV) parameters including stress index (SI), HRV index, SDNN, RMSSD, pNN50, LF, HF, and LF/HF were analyzed...
March 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29570600/the-age-of-peak-marathon-performance-in-cross-country-skiing-the-engadin-ski-marathon
#11
Beat Knechtle, Pantelis T Nikolaidis
Knechtle, B and Nikolaidis, PT. The age of peak marathon performance in cross-country skiing-the "Engadin Ski Marathon." J Strength Cond Res 32(4): 1131-1136, 2018-The age of the best endurance performance has been well investigated in flat city running marathons. However, we have no knowledge about the age of peak marathon performance in cross-country skiing, which would be of great practical value for athletes and coaches. Therefore, the aim of the present study was to examine the age of peak marathon performance in cross-country skiing...
April 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29568244/herbal-medicine-for-sports-a-review
#12
REVIEW
Maha Sellami, Olfa Slimeni, Andrzej Pokrywka, Goran Kuvačić, Lawrence D Hayes, Mirjana Milic, Johnny Padulo
The use of herbal medicinal products and supplements has increased during last decades. At present, some herbs are used to enhance muscle strength and body mass. Emergent evidence suggests that the health benefits from plants are attributed to their bioactive compounds such as Polyphenols, Terpenoids, and Alkaloids which have several physiological effects on the human body. At times, manufacturers launch numerous products with banned ingredient inside with inappropriate amounts or fake supplement inducing harmful side effect...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29562613/effects-of-low-versus-moderate-glycemic-index-diets-on-aerobic-capacity-in-endurance-runners-three-week-randomized-controlled-crossover-trial
#13
Krzysztof Durkalec-Michalski, Emilia E Zawieja, Bogna E Zawieja, Dominika Jurkowska, Maciej S Buchowski, Jan Jeszka
The glycemic index (GI) of ingested carbohydrates may influence substrate oxidation during exercise and athletic performance. Therefore, the aim of this study was to assess the effect of low- and moderate-GI three-week diets on aerobic capacity and endurance performance in runners. We conducted a randomized crossover feeding study of matched diets differing only in GI (low vs. moderate) in 21 endurance-trained runners. Each participant consumed both, low- (LGI) and moderate-GI (MGI) high-carbohydrate (~60%) and nutrient-balanced diets for three weeks each...
March 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29547891/signatures-of-selection-on-standing-genetic-variation-underlie-athletic-and-navigational-performance-in-racing-pigeons
#14
Malgorzata A Gazda, Pedro Andrade, Sandra Afonso, Jolita Dilyte, John P Archer, Ricardo J Lopes, Rui Faria, Miguel Carneiro
Racing pigeons have been selectively bred to find their way home quickly over what are often extremely long distances. This breed is of substantial commercial value and is also an excellent avian model to gain empirical insights into the evolution of traits associated with flying performance and spatial orientation. Here, we investigate the molecular basis of the superior athletic and navigational capabilities of racing pigeons using whole-genome and RNA sequencing data. We inferred multiple signatures of positive selection distributed across the genome of racing pigeons...
March 13, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29544062/ingestion-of-carbohydrate-or-carbohydrate-plus-protein-does-not-enhance-performance-during-endurance-exercise-a-randomized-cross-over-placebo-controlled-clinical-trial
#15
Débora Finger, Fábio Juner Lanferdini, Juliano Boufleur Farinha, Clarissa Müller Brusco, Lucas Helal, Francesco Pinto Boeno, Eduardo Lusa Cadore, Ronei Silveira Pinto
INTRODUCTION: Protein (PRO) combined with a carbohydrate (CHO) beverage may have an ergogenic effect on endurance performance. However, evidence regarding its efficacy on similar conditions to athletes' race day is still lacking. OBJECTIVE: To compare the effect of three different nutritional supplementation strategies on performance and muscle recovery in a duathlon protocol. METHODS: , 13 male athletes (29.7 ± 7.7 years) participated in three simulated Olympic-distance duathlons under three different, randomly assigned, supplementation regimens: carbohydrate drink (CHO, 75 g); isocaloric CHO plus protein drink (CHO+PRO, 60...
March 15, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29543071/factors-that-influence-the-rating-of-perceived-exertion-after-endurance-training
#16
Lilian Roos, Wolfgang Taube, Carolin Tuch, Klaus Michael Frei, Thomas Wyss
PURPOSE: Session rating of perceived exertion (sRPE) is an often used measure to assess athletes' training load. However, little is known which factors could optimize the quality of data collection thereof. The aim of the present study was to investigate the effects of (i) the survey methods and (ii) the time points when sRPE was assessed on the correlation between subjective (sRPE) and objective (heart rate training impulse; TRIMP) assessment of training load. METHODS: In the first part, 45 well-trained subjects (30 men, 15 women) performed 20 running sessions with a heart rate monitor and reported sRPE 30 minutes after training cessation...
March 15, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29535585/effect-of-endurance-training-on-the-lactate-and-glucose-minimum-intensities
#17
Pedro B Junior, Vitor L de Andrade, Eduardo Z Campos, Carlos A Kalva-Filho, Alessandro M Zagatto, Gustavo G de Araújo, Marcelo Papoti
Due to the controversy about the sensitive of lactate minimum intensity (LMI) to training and the need to develop other tool for aerobic fitness evaluation, the purpose of this study was to analyze the sensitivity of glucose minimum intensity (GMI) and LMI to endurance training. Eight trained male cyclists (21.4 ± 1.9 years, 67.6 ± 7.5 kg and 1.72 ± 0.10 m) were evaluated twice, before and after 12 weeks of training. GMI and LMI were calculated, respectively, by the lowest blood glucose and lactate values attained during an incremental test performed after a hyperlactemia induction, and VO2 max was determined during standard incremental effort...
March 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29534465/effect-of-a-protein-supplement-on-the-gut-microbiota-of-endurance-athletes-a-randomized-controlled-double-blind-pilot-study
#18
Diego Moreno-Pérez, Carlo Bressa, María Bailén, Safa Hamed-Bousdar, Fernando Naclerio, Manuel Carmona, Margarita Pérez, Rocío González-Soltero, Maria Gregoria Montalvo-Lominchar, Claudia Carabaña, Mar Larrosa
Nutritional supplements are popular among athletes to improve performance and physical recovery. Protein supplements fulfill this function by improving performance and increasing muscle mass; however, their effect on other organs or systems is less well known. Diet alterations can induce gut microbiota imbalance, with beneficial or deleterious consequences for the host. To test this, we performed a randomized pilot study in cross-country runners whose diets were complemented with a protein supplement (whey isolate and beef hydrolysate) ( n = 12) or maltodextrin (control) ( n = 12) for 10 weeks...
March 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29528959/seasonal-changes-in-anthropometric-physiological-nutritional-and-performance-factors-in-collegiate-rowers
#19
Kenji Kuzuhara, Kanako Katai, Tatsuya Hojo, Yoshihiko Fujisawa, Misaka Kimura, Yasuyoshi Yanagida, Yosuke Yamada, Junta Iguchi
Well-controlled seasonal distribution of training intensity appears to be an important variable for endurance athletes' success as competitors and/or for avoidance of overtraining. The aim of this study was to examine the interrelationships of training distribution, body composition, energy intake/expenditure, and rowing ergometer performance throughout the 2012-2013 season. In the present study of 15 collegiate male rowers, most of whom started rowing during their time at the university, we divided the 2012-2013 season (total 37 weeks) into 3 phases (off-season, December to mid-March, 16 weeks; pre-season, late March to April, 5 weeks; and in-season, May to August, 16 weeks) and analyzed the transition of 2000-m rowing ergometer time, training intensity/volume, body composition (body weight and body fat) and energy intake/expenditure in each phase...
March 6, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29509641/caffeine-cyp1a2-genotype-and-endurance-performance-in-athletes
#20
Nanci Guest, Paul Corey, Jason Vescovi, Ahmed El-Sohemy
PURPOSE: Many studies have examined the effect of caffeine on exercise performance, but findings have not always been consistent. The objective of this study was to determine whether variation in the CYP1A2 gene, which affects caffeine metabolism, modifies the ergogenic effects of caffeine in a 10-km cycling time trial. METHODS: Competitive male athletes (n=101; age: 25 ± 4 years) completed the time trial under three conditions: 0, 2 or 4 mg of caffeine per kg body mass, using a split-plot randomized, double-blinded, placebo-controlled design...
March 5, 2018: Medicine and Science in Sports and Exercise
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