keyword
https://read.qxmd.com/read/38547128/examining-factors-related-to-low-performance-of-predicting-remission-in-participants-with-major-depressive-disorder-using-neuroimaging-data-and-other-clinical-features
#21
JOURNAL ARTICLE
Junying Wang, David D Wu, Christine DeLorenzo, Jie Yang
Major depressive disorder (MDD), a prevalent mental health issue, affects more than 8% of the US population, and almost 17% in the young group of 18-25 years old. Since Covid-19, its prevalence has become even more significant. However, the remission (being free of depression) rates of first-line antidepressant treatments on MDD are only about 30%. To improve treatment outcomes, researchers have built various predictive models for treatment responses and yet none of them have been adopted in clinical use. One reason is that most predictive models are based on data from subjective questionnaires, which are less reliable...
2024: PloS One
https://read.qxmd.com/read/38547099/etonogestrel-releasing-subdermal-contraceptive-implant-budget-impact-analysis-based-on-the-brazilian-private-healthcare-system
#22
JOURNAL ARTICLE
Agnaldo Lopes da Silva Filho, Ricardo Luis Pereira Bueno, Yohanna Ramires, Lara Marina Cruz Lino
High rates of unplanned pregnancies persist despite pharmacological developments and advancements in contraceptive methods. Here, we demonstrate that the etonogestrel-releasing subdermal contraceptive implant (IMP-ETN) may be an appropriate and cost-effective alternative to levonorgestrel-releasing intrauterine systems (LNG-IUSs) for women in Brazil. For our pharmacoeconomic analysis, we reviewed the literature on IMP-ETN regarding its acceptance, eligibility criteria, choice, relations with age, adverse events and, finally, the unmet need in the fee-for-service private healthcare sector...
2024: PloS One
https://read.qxmd.com/read/38547076/pricing-decision-and-channel-selection-of-fresh-agricultural-products-dual-channel-supply-chain-based-on-blockchain
#23
JOURNAL ARTICLE
Di Wang, Xiaoyue Tian, Mengchao Guo
The application of blockchain can effectively improve the efficiency of fresh agricultural product circulation and consumer trust, but it can also increase investment costs. In this context, this paper introduces parameters such as blockchain unit variable cost, the level of blockchain technology investment, and consumer channel preference in two dual-channel supply chain systems dominated by fresh agricultural product manufacturers: online direct sales and distribution. It compares and analyzes pricing and channel selection strategies in both cases of not using and using blockchain...
2024: PloS One
https://read.qxmd.com/read/38546994/knowledge-augmented-visual-question-answering-with-natural-language-explanation
#24
JOURNAL ARTICLE
Jiayuan Xie, Yi Cai, Jiali Chen, Ruohang Xu, Jiexin Wang, Qing Li
Visual question answering with natural language explanation (VQA-NLE) is a challenging task that requires models to not only generate accurate answers but also to provide explanations that justify the relevant decision-making processes. This task is accomplished by generating natural language sentences based on the given question-image pair. However, existing methods often struggle to ensure consistency between the answers and explanations due to their disregard of the crucial interactions between these factors...
March 28, 2024: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://read.qxmd.com/read/38546989/adaptiveclick-click-aware-transformer-with-adaptive-focal-loss-for-interactive-image-segmentation
#25
JOURNAL ARTICLE
Jiacheng Lin, Jiajun Chen, Kailun Yang, Alina Roitberg, Siyu Li, Zhiyong Li, Shutao Li
Interactive image segmentation (IIS) has emerged as a promising technique for decreasing annotation time. Substantial progress has been made in pre-and post-processing for IIS, but the critical issue of interaction ambiguity, notably hindering segmentation quality, has been under-researched. To address this, we introduce AdaptiveClick - a click-aware transformer incorporating an adaptive focal loss (AFL) that tackles annotation inconsistencies with tools for mask-and pixel-level ambiguity resolution. To the best of our knowledge, AdaptiveClick is the first transformer-based, mask-adaptive segmentation framework for IIS...
March 28, 2024: IEEE Transactions on Neural Networks and Learning Systems
https://read.qxmd.com/read/38546964/chronic-obstructive-pulmonary-disease-in-heart-failure-challenges-in-diagnosis-and-treatment-for-hfpef-and-hfref
#26
REVIEW
Sergio Henrique Rodolpho Ramalho, André Luiz Pereira de Albuquerque
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is common in heart failure (HF), and it has a significant impact on the prognosis and quality of life of patients. Additionally, COPD is independently associated with lower adherence to first-line HF therapies. In this review, we outline the challenges of identifying and managing HF with preserved (HFpEF) and reduced (HFrEF) ejection fraction with coexisting COPD. RECENT FINDINGS: Spirometry is necessary for COPD diagnosis and prognosis but is underused in HF...
March 28, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38546912/a-comparison-of-patient-reported-outcomes-in-patients-undergoing-abdominal-wall-repair-with-either-synthetic-or-biosynthetic-mesh-a-pilot-study
#27
JOURNAL ARTICLE
G V Kulkarni, Z Elliott, R Rudd, D Barnes, T M Hammond
PURPOSE: Repair of midline ventral incisional hernias (VIHR) requires mesh reinforcement. Mesh types can be categorised into synthetic, biosynthetic, or biological. There is a lack of evidence to support one type of mesh over another. The aim of this pilot study was to compare mesh sensation in patients having undergone elective open repair with synthetic or biosynthetic mesh. METHODS: Four years of prospectively collected data were retrospectively reviewed on 40 patients who had undergone VIHR, using either biosynthetic or synthetic mesh placed in the retromuscular plane...
March 28, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38546896/development-of-a-nomogram-to-predict-the-prognosis-of-patients-with-secondary-bone-tumors-in-the-intensive-care-unit-a-retrospective-analysis-based-on-the-mimic-iv-database
#28
JOURNAL ARTICLE
Weikang Li, Jinliang Li, Jinkui Cai
PURPOSE: The present study aimed to develop a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit to facilitate risk stratification and treatment planning. METHODS: We used the MIMIC IV 2.0 (the Medical Information Mart for Intensive Care IV) to retrieve patients with secondary bone tumors as a study cohort. To evaluate the predictive ability of each characteristic on patient mortality, stepwise Cox regression was used to screen variables, and the selected variables were included in the final Cox proportional hazard model...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38546892/influence-of-degree-of-substitution-on-the-hydroxypropyl-%C3%AE-cyclodextrin-complexation-with-rifampicin-in-water-solution-a-molecular-simulation
#29
JOURNAL ARTICLE
Elena Alvira
CONTEXT: Hydroxypropyl-β-cyclodextrin (HPβCD) is one of the derivatized cyclodextrins most widely used as an excipient in the pharmaceutical industry, for its capacity to improve certain drugs properties. Different configurations of HPβCD are possible depending on the number and location of the 2-hydroxypropyl groups substituted on the glucose rings. Rifampicin has become the most commonly clinically used antibiotic against tuberculosis in recent years, despite its low solubility and variable bioavailability...
March 28, 2024: Journal of Molecular Modeling
https://read.qxmd.com/read/38546873/decision-regret-of-cancer-patients-after-radiotherapy-results-from-a-cross-sectional-observational-study-at-a-large-tertiary-cancer-center-in-germany
#30
JOURNAL ARTICLE
Alexander Rühle, Leonie Wieland, Andreas Hinz, Anja Mehnert-Theuerkauf, Nils H Nicolay, Clemens Seidel
PURPOSE: The decision-making process regarding cancer treatment is emotionally challenging for patients and families, harboring the risk of decision regret. We aimed to explore prevalence and determinants of decision regret following radiotherapy. METHODS: This cross-sectional observational study was conducted at a tertiary cancer center to assess decision regret following radiotherapy. The study employed the German version of the Ottawa Decision Regret Scale (DRS) which was validated in the study population...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38546868/changes-in-stress-urinary-incontinence-symptoms-after-pelvic-organ-prolapse-surgery-a-nationwide-cohort-study-finpop
#31
JOURNAL ARTICLE
Päivi K Karjalainen, Anna-Maija Tolppanen, Olga Wihersaari, Kari Nieminen, Nina K Mattsson, Jyrki T Jalkanen
INTRODUCTION AND HYPOTHESIS: Various strategies are employed to manage stress urinary incontinence (SUI) during pelvic organ prolapse (POP) surgery. This study was aimed at facilitating shared decision-making by evaluating SUI symptom changes, staged SUI procedures, and their prognostic factors following POP surgery without concomitant SUI intervention. METHODS: We analyzed 2,677 POP surgeries from a population-based observational cohort, excluding patients with prior SUI surgery...
March 28, 2024: International Urogynecology Journal
https://read.qxmd.com/read/38546864/-artificial-intelligence-in-intensive-care-medicine
#32
REVIEW
André Baumgart, Grietje Beck, David Ghezel-Ahmadi
The integration of artificial intelligence (AI) into intensive care medicine has made considerable progress in recent studies, particularly in the areas of predictive analytics, early detection of complications, and the development of decision support systems. The main challenges remain availability and quality of data, reduction of bias and the need for explainable results from algorithms and models. Methods to explain these systems are essential to increase trust, understanding, and ethical considerations among healthcare professionals and patients...
March 28, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38546846/unveiling-cardiac-involvement-in-juvenile-dermatomyositis-through-speckle-tracking-echocardiography
#33
JOURNAL ARTICLE
Reyhan Dedeoglu, Nujin Ulug Murt, Aybüke Gunalp, Yusuf İskender Cosgun, Funda Oztunc, Savas Dedeoglu, Amra Adrovic, Sezgin Sahin, Mehmet Yıldız, Kenan Barut, Esma Aslan, Elif Kılıc Konte, Ümit Gul, Ozgur Kasapcopur
Early detection of cardiac involvement in Juvenile Dermatomyositis (JDM) is difficult due to the absence of clinical signs and symptoms, with systolic dysfunction often emerging in late stages and associated with a poor prognosis. This study aimed to employ two-dimensional speckle-tracking echocardiography (STE) for subclinical assessment of left ventricular (LV) systolic failure in JDM and explore potential associations between impaired LV systolic function (LV-GLS) and disease activity. A prospective study enrolled 20 healthy volunteers and 26 JDM patients (< 18 years old) without cardiac symptoms...
March 28, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38546837/predicting-deamidation-and-isomerization-sites-in-therapeutic-antibodies-using-structure-based-in-silico-approaches
#34
JOURNAL ARTICLE
David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R Karow-Zwick, Giuseppe Licari
Asparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such, the early engineering and selection of chemically stable monoclonal antibodies (mAbs) can substantially mitigate the risk of subsequent failure. In this study, we introduce a novel in silico approach for predicting deamidation and isomerization sites in therapeutic antibodies by analyzing the structural environment surrounding asparagine and aspartate residues...
2024: MAbs
https://read.qxmd.com/read/38546802/trends-in-burdens-of-disease-by-transmission-source-usa-2005-2020-and-hazard-identification-for-foods-focus-on-milkborne-disease
#35
JOURNAL ARTICLE
Michele M Stephenson, Margaret E Coleman, Nicholas A Azzolina
BACKGROUND: Robust solutions to global, national, and regional burdens of communicable and non-communicable diseases, particularly related to diet, demand interdisciplinary or transdisciplinary collaborations to effectively inform risk analysis and policy decisions. OBJECTIVE: U.S. outbreak data for 2005-2020 from all transmission sources were analyzed for trends in the burden of infectious disease and foodborne outbreaks. METHODS: Outbreak data from 58 Microsoft Access® data tables were structured using systematic queries and pivot tables for analysis by transmission source, pathogen, and date...
March 28, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38546788/publication-bias-in-upper-gastrointestinal-oncology-clinical-trials
#36
JOURNAL ARTICLE
Trenton Lippert, Erin Schmucker, Anchal Shukla, Ruha Reddy, Pooja Neerumalla, Gabriella Blanco, Vic Velanovich
PURPOSE: Evidence-based medicine requires evaluation of the medical literature to guide clinical reasoning and treatment recommendations. The presence of publication bias towards exclusion of non-statistically significant clinical trials may be leading to an incomplete evaluation of the literature and cause potentially incomplete guidance for patients. We aimed to compare publication rates and impact of publications of positive and negative outcome clinical trials. METHODS: We queried the US National Library of Medicine Clinical Trials database identifying clinical trials with reported results on the topics of pancreatic, liver, and gastric cancer...
March 28, 2024: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/38546781/do-decision-aids-improve-clinical-practice
#37
JOURNAL ARTICLE
Vanessa Jordan
No abstract text is available yet for this article.
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546770/utilisation-of-in-consultation-supervisor-assistance-in-general-practice-training-and-personal-cost-to-trainees-a-cross-sectional-study
#38
JOURNAL ARTICLE
Nancy Sturman, Amanda Tapley, Elizabeth Holliday, Alison Fielding, Andrew Davey, Mieke van Driel, Jean Ball, Kristen FitzGerald, Neil Spike, Parker Magin
Aim The aim of the study was to establish whether two previously described barriers to effective in-consultation assistance-seeking by general practice (GP) vocational specialist trainees (ie concern about patient impressions of their competence, and discomfort presenting to supervisors in front of patients) influenced the frequency of trainee in-consultation assistance-seeking from their supervisor. Methods This was a cross-sectional study nested in the Registrar Clinical Encounters in Clinical Training ongoing cohort study of Australian GP trainees...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546730/development-and-external-validation-of-machine-learning-models-for-diabetic-microvascular-complications-cross-sectional-study-with-metabolites
#39
JOURNAL ARTICLE
Feng He, Clarissa Ng Yin Ling, Simon Nusinovici, Ching-Yu Cheng, Tien Yin Wong, Jialiang Li, Charumathi Sabanayagam
BACKGROUND: Diabetic kidney disease (DKD) and diabetic retinopathy (DR) are major diabetic microvascular complications, contributing significantly to morbidity, disability, and mortality worldwide. The kidney and the eye, having similar microvascular structures and physiological and pathogenic features, may experience similar metabolic changes in diabetes. OBJECTIVE: This study aimed to use machine learning (ML) methods integrated with metabolic data to identify biomarkers associated with DKD and DR in a multiethnic Asian population with diabetes, as well as to improve the performance of DKD and DR detection models beyond traditional risk factors...
March 28, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38546726/implementation-of-cyp2c19-and-cyp2d6-genotyping-to-guide-antidepressant-use-in-a-large-rural-health-system
#40
JOURNAL ARTICLE
Natasha J Petry, Joel Van Heukelom, April J Schultz, Kristen Jacobsen, Jordan F Baye, Sarah Mills, Debbie Figueroa, Amanda Massmann
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: We describe the implementation and ongoing maintenance of CYP2C19 and CYP2D6 focused pharmacogenetic (PGx) testing to guide antidepressant and antianxiety medication prescriptions in a large rural, nonprofit health system...
March 28, 2024: American Journal of Health-system Pharmacy: AJHP
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