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https://www.readbyqxmd.com/read/29156756/mir-221-regulated-kit-level-by-wild-type-or-leukemia-mutant-runx1-a-determinant-of-single-myeloblast-fate-decisions-that-collectively-drives-or-hinders-granulopoiesis
#1
Stefano Rossetti, Michael J Anauo, Nicoletta Sacchi
RUNX1, a master transcription factor of hematopoiesis, was shown to orchestrate both cell proliferation and differentiation during granulopoiesis by regulating microRNAs (miRs). In this study, taking advantage of the miR-ON reporter system, we monitored first, how the granulocyte colony stimulation factor (GCSF) temporally modulates the concomitant level variation of miR-221 and one of its prototypic targets, the stem cell factor receptor KIT, in single 32D(miR-ON-221) myeloblasts expressing wild type RUNX1...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156744/changes-of-alpha-fetoprotein-levels-could-predict-recurrent-hepatocellular-carcinoma-survival-after-trans-arterial-chemoembolization
#2
Chao He, Xiaoyun Zhang, Chuan Li, Wei Peng, Tian-Fu Wen, Lv-Nan Yan, Jiayin Yang, Wusheng Lu
Background: There is paucity of information concerning whether AFP change is a predictor of prognosis for recurrent hepatocellular carcinoma (RHCC) patients after trans-arterial chemoembolization (TACE). Methods: A total of 177 RHCC patients who received TACE as first-line therapy were retrospectively analyzed. The patients were classified into three groups according to their pre-TACE and post-TACE AFP levels (group A: AFP decreased, group B: AFP consistent normal, and group C: AFP increased)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156653/dual-competing-photovoltaic-supply-chains-a-social-welfare-maximization-perspective
#3
Zhisong Chen, Shong-Iee Ivan Su
In the past decades, the inappropriate subsidy policies in many nations have caused problems such as serious oversupply, fierce competition and subpar social welfare in the photovoltaic (PV) industry in many nations. There is a clear shortage in the PV industry literature regarding how dual supply chains compete and the key decision issues regarding the competition between dual PV supply chains. It is critical to develop effective subsidy policies for the competing PV supply chains to achieve social welfare maximization...
November 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29156536/a-review-on-exudates-detection-methods-for-diabetic-retinopathy
#4
REVIEW
Shilpa Joshi, P T Karule
The presence of exudates on the retina is the most characteristic symptom of diabetic retinopathy. As exudates are among early clinical signs of DR, their detection would be an essential asset to the mass screening task and serve as an important step towards automatic grading and monitoring of the disease. Reliable identification and classification of exudates are of inherent interest in an automated diabetic retinopathy screening system. Here we review the numerous early studies that used for automatic exudates detection with the aim of providing decision support in addition to reducing the workload of an ophthalmologist...
November 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156498/first-things-first-risk-model-performance-metrics-should-reflect-the-clinical-application
#5
Kathleen F Kerr, Holly Janes
Developing new measures of risk model performance is an active line of research, often motivated by the conventional wisdom that area under the ROC curve is an 'insensitive' measure of the additional predictive capacity offered by new biomarkers. Without endorsing area under the ROC curve, we argue that this charge is not substantiated. Three articles in this issue discuss alternative metrics of risk model performance: NRI(p) (two-category net reclassification index at the event rate), integrated discrimination index, and R-squared statistics...
December 10, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29156490/-the-citizen-is-stepping-into-a-new-role-policy-interpretations-of-patient-and-public-involvement-in-finland
#6
Marjaana Jones, Ilkka Pietilä
Involving patients and the public in healthcare decision-making is on the policy agenda in several countries. The aim of our study was to describe and analyse the development of patient and public involvement from a policy perspective. We argue that the language of health policies can influence both the aims and the development of involvement methods. In this study health policy documents, which have guided the development of patient and public involvement in Finland have been analysed using methods of Membership Categorisation Analysis...
November 20, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29156474/ct-and-mri-findings-in-cerebral-aspergilloma
#7
Friederike Gärtner, Julia Forstenpointner, Birgit Ertl-Wagner, Babak Hooshmand, Christian Riedel, Olav Jansen
Purpose Invasive aspergillosis usually affects immunocompromised patients. It carries a high risk of morbidity and mortality and usually has a nonspecific clinical presentation. Early diagnosis is essential in order to start effective treatment and improve clinical outcome. Materials and Methods In a retrospective search of the PACS databases from two medical centers, we identified 9 patients with histologically proven cerebral aspergilloma. We systematically analyzed CT and MRI imaging findings to identify typical imaging appearances of cerebral aspergilloma...
November 20, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29156437/home-composting-using-different-ratios-of-bulking-agent-to-food-waste
#8
Lucas Lourenço Castiglioni Guidoni, Roger Vasques Marques, Rodrigo Bilhalva Moncks, Fabiana Torma Botelho, Matheus Francisco da Paz, Luciara Bilhalva Corrêa, Érico Kunde Corrêa
The negative environmental impacts associated with home composting may be due to the absence of a defined operation criteria for the degradation process. In addition to the potentially low environmental impact in terms of energy and water usage, which is minimal to the manufacture of the composting unit and avoiding the processing and transportation of waste or byproduct, composting at home can also promote a reduction in the emission of unpleasant gases. The proportion of the food waste and bulking agents in the composting mixture may be decisive to fulfill good practices of waste stabilization...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156435/more-than-a-to-b-understanding-and-managing-visitor-spatial-behaviour-in-urban-forests-using-public-participation-gis
#9
Silviya Korpilo, Tarmo Virtanen, Tiina Saukkonen, Susanna Lehvävirta
Planning and management needs up-to-date, easily-obtainable and accurate information on the spatial and social aspects of visitor behaviour in order to balance human use and impacts, and protection of natural resources in public parks. We used a web-based public participation GIS (PPGIS) approach to gather citizen data on visitor behaviour in Helsinki's Central Park in order to aid collaborative spatial decision-making. The study combined smartphone GPS tracking, route drawing and a questionnaire to examine differences between user groups in their use of formal trails, off-trail behaviour and the motivations that affect it...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156284/temporal-characterization-and-statistical-analysis-of-flowback-and-produced-waters-and-their-potential-for-reuse
#10
Karl Oetjen, Kevin E Chan, Kristoffer Gulmark, Jan H Christensen, Jens Blotevogel, Thomas Borch, John R Spear, Tzahi Y Cath, Christopher P Higgins
Hydraulic fracturing (HF) has allowed for the utilization of previously unattainable shale oil and gas (O&G) resources. After HF is complete, the waters used to increase the facies' permeability return uphole as wastewaters. When these waters return to the surface, they are characterized by complex organic and inorganic chemistry, and can pose a health risk if not handled correctly. Therefore, these waters must be treated or disposed of properly. However, the variability of these waters' chemical composition over time is poorly understood and likely limits the applicability of their reuse...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156275/agricultural-susceptibility-to-monsoon-variability-a-district-level-analysis-of-maharashtra-india
#11
Deepika Swami, Prashant Dave, Devanathan Parthasarathy
Indian Summer Monsoon (ISM) variability has always been a feature affecting Indian agriculture. However, nature of this variability is varying in the backdrop of climate change, and as a consequence, agriculture is getting significantly affected and subsequently threatening food security. To address the climate variability, most of the studies conducted so far have focused on a coarse scale such as Central India or Western Ghats. However, finer scale analysis for identification and quantification of the link between agriculture vulnerability and climate variables has not yet been attempted in a comprehensive manner...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156228/effect-of-abiotic-and-biotic-stress-factors-analysis-using-machine-learning-methods-in-zebrafish
#12
Rajasekar Gutha, Suresh Yarrappagaari, Lavanya Thopireddy, Kesireddy Sathyavelu Reddy, Rajeswara Reddy Saddala
In order to understand the mechanisms underlying stress responses, meta-analysis of transcriptome is made to identify differentially expressed genes (DEGs) and their biological, molecular and cellular mechanisms in response to stressors. The present study is aimed at identifying the effect of abiotic and biotic stress factors, and it is found that several stress responsive genes are common for both abiotic and biotic stress factors in zebrafish. The meta-analysis of micro-array studies revealed that almost 4...
November 11, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29156198/the-evolving-role-of-genomic-testing-in-assessing-prognosis-of-patients-with-myelodysplastic-syndromes
#13
REVIEW
David P Steensma
The introduction into routine hematology-oncology clinical practice of molecular genetic testing assays based on next-generation sequencing platforms is prompting reassessment of the importance of molecular assay results in comparison to existing disease-specific risk stratification tools based on clinical assessment and light microscopy. For patients with myelodysplastic syndromes (MDS), the most commonly used tools for prognostication currently include the International Prognostic Scoring System (IPSS) and the Revised IPSS (IPSS-R), which are based on marrow blast proportion, number and degree of cytopenias, and the metaphase karyotype...
December 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29156100/doctoral-training-in-clinical-psychology-across-23-years-continuity-and-change
#14
John C Norcross, Michael A Sayette, Andrew M Pomerantz
OBJECTIVE: Doctoral training in clinical psychology has undergone substantial changes in recent decades, especially with the increasing heterogeneity of training models and graduate students. To document these changes, we analyzed program, student, and faculty characteristics of American Psychological Association (APA)-accredited clinical psychology programs over a 23-year span. METHOD: We surveyed directors of clinical training about their doctoral programs every 2 years from 1991 to 2013, securing 90%-98% response rates...
November 20, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29155897/advances-in-applied-homeostatic-modelling-of-the-relationship-between-thyrotropin-and-free-thyroxine
#15
Rudolf Hoermann, John Edward Maurice Midgley, Rolf Larisch, Johannes Wolfgang Christian Dietrich
INTRODUCTION: The relationship between pituitary TSH and thyroid hormones is central to our understanding of thyroid physiology and thyroid function testing. Here, we generated distribution patterns by using validated tools of thyroid modelling. METHODS: We simulated patterns of individual set points under various conditions, based on a homeostatic model of thyroid feedback control. These were compared with observed data points derived from clinical trials. RESULTS: A random mix of individual set points was reconstructed by simulative modelling with defined structural parameters...
2017: PloS One
https://www.readbyqxmd.com/read/29155835/assessment-of-transposition-of-the-great-arteries-associated-with-multiple-malformations-using-dual-source-computed-tomography
#16
Lin-Jun Xie, Li Jiang, Zhi-Gang Yang, Ke Shi, Hua-Yan Xu, Rui Li, Kai-Yue Diao, Ying-Kun Guo
PURPOSE: To determine the value of dual-source computed tomography (DSCT) in depicting the morphological characteristics and diagnosing the associated malformations for patients with transposition of the great arteries (TGA) before surgery. MATERIALS AND METHODS: Twenty-five patients with TGA who underwent DSCT and transthoracic echocardiography (TTE) examination were retrospectively reviewed. The morphological types of TGA, the spatial relationship between the pulmonary artery and the aorta, as well as coronary artery-associated abnormalities were assessed by DSCT...
2017: PloS One
https://www.readbyqxmd.com/read/29155812/fluevidencesynthesis-an-r-package-for-evidence-synthesis-based-analysis-of-epidemiological-outbreaks
#17
Edwin van Leeuwen, Petra Klepac, Dominic Thorrington, Richard Pebody, Marc Baguelin
Public health related decisions often have to balance the cost of intervention strategies with the benefit of the reduction in disease burden. While the cost can often be inferred, forward modelling of the effect of different intervention options is complicated and disease specific. Here we introduce a package that is aimed to simplify this process. The package allows one to infer parameters using a Bayesian approach, perform forward modelling of the likely results of the proposed intervention and finally perform cost effectiveness analysis of the results...
November 20, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29155609/using-neural-networks-to-predict-hfacs-unsafe-acts-from-the-pre-conditions-of-unsafe-acts
#18
Don Harris, Wen-Chin Li
HFACS (Human Factors Analysis and Classification System) is based upon Reason's (1990; 1997) organizational model of human error which suggests that there is a 'one to many' mapping of condition tokens (HFACS level 2 psychological precursors) to unsafe act tokens (HFACS level 1 error and violations). Using accident data derived from 523 military aircraft accidents, the relationship between HFACS level 2 pre-conditions and level 1 unsafe acts was modelled using an artificial Neural Network (NN). This allowed an empirical model to be developed congruent with the underlying theory of HFACS...
November 18, 2017: Ergonomics
https://www.readbyqxmd.com/read/29155608/history-of-lobotomy-in-poland
#19
Kinga Jęczmińska
In Poland, there were 176 cases of prefrontal leucotomy performed by Moniz's method between 1947 and 1951. There were also several cases in which alternative psychosurgical techniques were used: prefrontal topectomy by Bilikiewicz and colleagues, and prefrontal topischemia by Ziemnowicz. This article analyses the following: publications by Choróbski, who performed lobotomy in Poland, and by Korzeniowski, who assessed its short-term results; a report by Bornsztajn, who reviewed general results of the method; and clinical research by Broszkiewicz and by Konieczyńska, who assessed Polish patients in terms of long-term results of lobotomy...
November 1, 2017: History of Psychiatry
https://www.readbyqxmd.com/read/29155445/individualizing-prevention-for-older-adults
#20
Sei J Lee, Christine M Kim
Prevention can help older adults avoid illness by identifying and addressing conditions before they cause symptoms, but prevention can also harm older adults if conditions that are unlikely to cause symptoms in the individual's lifetime are identified and treated. To identify older adults who preventive interventions are most likely to benefit (and most likely to harm), we propose a framework that compares an individual's life expectancy (LE) with the time to benefit (TTB) for an intervention. If LE is less than the TTB, the individual is unlikely to benefit but is exposed to the risks of the intervention, and the intervention should generally NOT be recommended...
November 20, 2017: Journal of the American Geriatrics Society
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