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https://www.readbyqxmd.com/read/29909601/assessment-of-the-dual-role-of-clumping-factor-a-in-s-aureus-adhesion-to-endothelium-in-absence-and-presence-of-plasma
#1
Jorien Claes, Bartosz Ditkowski, Laurens Liesenborghs, Tiago Rafael Veloso, Jose M Entenza, Philippe Moreillon, Thomas Vanassche, Peter Verhamme, Marc F Hoylaerts, Ruth Heying
Adhesion of Staphylococcus aureus to endothelial cells (ECs) is paramount in infective endocarditis. Bacterial proteins such as clumping factor A (ClfA) and fibronectin binding protein A (FnbpA) mediate adhesion to EC surface molecules and (sub)endothelial matrix proteins including fibrinogen (Fg), fibrin, fibronectin (Fn) and von Willebrand factor (vWF). We studied the influence of shear flow and plasma on the binding of ClfA and FnbpA (including its sub-domains A, A16+ , ABC, CD) to coverslip-coated vWF, Fg/fibrin, Fn or confluent ECs, making use of Lactococcus lactis , expressing these adhesins heterologously...
June 17, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29909599/survival-of-aggressive-variants-of-papillary-thyroid-carcinoma-in-patients-under-55-years-old-a-seer-population-based-retrospective-analysis
#2
Jianhua Feng, Fei Shen, Wensong Cai, Xiaoxiong Gan, Xingyan Deng, Bo Xu
BACKGROUND: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. METHODS: All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013)...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29909596/osteogenesis-imperfecta-muscle-bone-interactions-when-bi-directionally-compromised
#3
REVIEW
Charlotte L Phillips, Youngjae Jeong
PURPOSE OF REVIEW: Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder of skeletal fragility and more recently muscle weakness. This review highlights our current knowledge of the impact of compromised OI muscle function on muscle-bone interactions and skeletal strength in OI. RECENT FINDINGS: The ramifications of inherent muscle weakness in OI muscle-bone interactions are just beginning to be elucidated. Studies in patients and in OI mouse models implicate altered mechanosensing, energy metabolism, mitochondrial dysfunction, and paracrine/endocrine crosstalk in the pathogenesis of OI...
June 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29909595/disability-experiences-and-perspectives-regarding-reproductive-decisions-parenting-and-the-utility-of-genetic-services-a-qualitative-study
#4
C Roadhouse, C Shuman, K Anstey, K Sappleton, D Chitayat, E Ignagni
Genetic counselors adopt seemingly contradictory roles: advocating for individuals with genetic conditions while offering prenatal diagnosis and the option of selective termination to prevent the birth of a child with a disability. This duality contributes to the tension between the disability and clinical genetics communities. Varying opinions exist amongst the disability community: some value genetic services while others are opposed. However, there is limited research exploring the opinions of individuals with a disability regarding issues related to reproduction and genetic services in the context of personal experience...
June 16, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29909572/the-%C3%AE-%C3%AE-crystallin-domain-of-lysinibacillus-sphaericus-phosphatidylinositol-phospholipase-c-plays-a-central-role-in-protein-stability
#5
Sebastián Cerminati, Luciana Paoletti, Salvador Peirú, Hugo G Menzella, María Eugenia Castelli
βγ-crystallin has emerged as a superfamily of structurally homologous proteins with representatives across all domains of life. A major portion of this superfamily is constituted by microbial members. This superfamily has also been recognized as a novel group of Ca2+ -binding proteins with a large diversity and variable properties in Ca2+ binding and stability. We have recently described a new phosphatidylinositol phospholipase C from Lysinibacillus sphaericus (LS-PIPLC) which was shown to efficiently remove phosphatidylinositol from crude vegetable oil...
June 16, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29909536/a-network-analysis-of-indirect-carbon-emission-flows-among-different-industries-in-china
#6
Qiang Du, Yadan Xu, Min Wu, Qiang Sun, Libiao Bai, Ming Yu
Indirect carbon emissions account for a large ratio of the total carbon emissions in processes to make the final products, and this implies indirect carbon emission flow across industries. Understanding these flows is crucial for allocating a carbon allowance for each industry. By combining input-output analysis and complex network theory, this study establishes an indirect carbon emission flow network (ICEFN) for 41 industries from 2005 to 2014 to investigate the interrelationships among different industries...
June 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909535/estimation-of-marginal-abatement-costs-of-co-2-in-chinese-provinces-under-2020-carbon-emission-rights-allocation-2005-2020
#7
Fumei Duan, Yong Wang, Ying Wang, Han Zhao
The calculation of marginal abatement costs of CO2 plays a vital role in meeting China's 2020 emission reduction targets by providing reference for determining carbon tax and carbon trading pricing. However, most existing researches only used one method to discuss regional and industrial marginal abatement costs, and almost no studies predicted future marginal abatement costs from the perspective of CO2 emission efficiency. To make up for the gaps, this paper first estimates marginal abatement costs of CO2 in three major industries of 30 provinces in China from 2005 to 2015 based on three assumptions...
June 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909497/a-retrospective-chart-review-of-children-with-asd-s-individual-education-plans-compared-to-subsequent-independent-psychological-evaluations
#8
Nicholas W Gelbar, Mary Beth Bruder, Emily DeBiase, John D Molteni
The heterogeneity of Autism Spectrum Disorder (ASD) makes it difficult for school-based professionals to develop effective Individual Education Plans (IEP) for this group. Limited research exists on the quality of IEP programs for individuals with ASD. This article summarizes the results of a retrospective chart review from an outpatient diagnostic center. Researchers collected data from IEPs and subsequent psychological evaluations of 75 individuals diagnosed with ASD. The implications of these results for future research and practice are discussed...
June 16, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29909461/timing-of-grip-and-goal-activation-during-action-perception-a-priming-study
#9
Jérémy Decroix, Solène Kalénine
Several models of action recognition acknowledge the involvement of distinct grip and goal representations in the processing of others' actions. Yet, their functional role and temporal organization are still debated. The present priming study aimed at evaluating the relative timing of grip and goal activation during the processing of photographs of object-directed actions. Action could be correct or incorrect owing to grip and/or goal violations. Twenty-eight (Experiment 1) and 25 (Experiment 2) healthy adults judged the correctness of target actions according to object typical use...
June 16, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29909458/what-about-the-herb-a-new-metabolomics-approach-for-synthetic-cannabinoid-drug-testing
#10
Lubertus Bijlsma, Rubén Gil-Solsona, Félix Hernández, Juan Vicente Sancho
Synthetic cannabinoids (SCs) are consumed as legal alternative to cannabis and often allow passing drug-screening tests. Their rapid transience on the drug scene, combined with their mostly unknown metabolic profiles, creates a scenario with constantly moving analytical targets, making their monitoring and identification challenging. The development of fast screening strategies for SCs, not directly focused on their chemical structure, as an alternative to the commonly applied target acquisition methods, would be highly appreciated in forensic and public health laboratories...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29909457/in-vivo-tumor-imaging-by-a-%C3%AE-glutamyl-transpeptidase-activatable-near-infrared-fluorescent-probe
#11
Lihong Li, Wen Shi, Xiaofeng Wu, Xiaohua Li, Huimin Ma
γ-Glutamyl transpeptidase (GGT), overexpressed in various cancer cells, has been perceived as a latent tumor biomarker. Thus, developing near-infrared (NIR) fluorescent GGT probes is highly desired for in vivo tumor imaging and studies. To our knowledge, however, such a GGT probe is still rare. Herein, we construct a new GGT-activatable NIR fluorescent probe HCAGlu by incorporating γ-glutamyl group as a recognition unit directly into a NIR hemicyanine fluorophore. HCAGlu exhibits a highly sensitive and selective NIR fluorescence off-on response to GGT...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29909441/annular-pancreas-in-china-9-years-experience-from-a-single-center
#12
REVIEW
DengLiang Wang, Quan Kang, ShuJun Shi, Wei Hu
To summarize the clinical characteristics, diagnosis, treatment and prognosis among 152 children with annular pancreas (AP). A retrospective review of 152 patients with AP who were treated with surgical repair between January 2009 and August 2017 was performed at our pediatric surgical units. Presenting symptoms, birth weight, radiological findings, associated anomalies, the type of surgery performed were analyzed. (1) 152 patients were identified, out of which 82 were males, and 70 were females; (2) the average birth weight of children with AP was less than that of healthy newborns...
June 16, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29909438/genetic-control-of-cole1-plasmid-stability-that-is-independent-of-plasmid-copy-number-regulation
#13
Melissa S Standley, Samuel Million-Weaver, David L Alexander, Shuai Hu, Manel Camps
ColE1-like plasmid vectors are widely used for expression of recombinant genes in E. coli. For these vectors, segregation of individual plasmids into daughter cells during cell division appears to be random, making them susceptible to loss over time when no mechanisms ensuring their maintenance are present. Here we use the plasmid pGFPuv in a recA relA strain as a sensitized model to study factors affecting plasmid stability in the context of recombinant gene expression. We find that in this model, plasmid stability can be restored by two types of genetic modifications to the plasmid origin of replication (ori) sequence: point mutations and a novel 269 nt duplication at the 5' end of the plasmid ori, which we named DAS (duplicated anti-sense) ori...
June 16, 2018: Current Genetics
https://www.readbyqxmd.com/read/29909402/impact-of-exercise-restriction-on-arrhythmic-risk-among-patients-with-arrhythmogenic-right-ventricular-cardiomyopathy
#14
Weijia Wang, Gabriela Orgeron, Crystal Tichnell, Brittney Murray, Jane Crosson, Oliver Monfredi, Julia Cadrin-Tourigny, Harikrishna Tandri, Hugh Calkins, Cynthia A James
BACKGROUND: Prior studies have shown a close link between exercise and development of arrhythmogenic right ventricular cardiomyopathy. How much exercise restriction reduces ventricular arrhythmia (VA), how genotype modifies its benefit, and whether it reduces risk sufficiently to defer implantable cardioverter-defibrillator (ICD) placement in arrhythmogenic right ventricular cardiomyopathy are unknown. METHODS AND RESULTS: We interviewed 129 arrhythmogenic right ventricular cardiomyopathy patients (age: 34...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909363/excitability-tests-using-high-density-surface-emg-a-novel-approach-to-studying-single-motor-units
#15
Boudewijn T H M Sleutjes, Judith Drenthen, Ernest Boskovic, Leonard J van Schelven, Maria O Kovalchuk, Paul G E Lumens, Leonard H van den Berg, Hessel Franssen
OBJECTIVE: To study excitability of single motor units (MUs) using high-density surface-EMG. METHODS: Motor unit action potentials (MUAPs) were evoked by submaximal stimulation of the median nerve at the wrist and recorded with a 9 × 14 electrode grid on the skin overlying the thenar muscles. For excitability tests of single MUs, the most optimal specific single-channel surface-EMG signal was selected based on the spatiotemporal profile of single MUs. RESULTS: Axonal excitability measures were successfully obtained from 14 single MUs derived from ten healthy subjects...
June 1, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29909307/a-comparison-of-various-approaches-used-in-source-apportionments-for-precipitation-nitrogen-in-a-mountain-region-of-southwest-china
#16
Jian Cui, Fengwu Zhou, Min Gao, Liuyi Zhang, Leiming Zhang, Ke Du, Qiangmei Leng, Yuanzhu Zhang, Dongyi He, Fumo Yang, Andy Chan
Six different approaches are applied in the present study to apportion the sources of precipitation nitrogen making use of precipitation data of dissolved inorganic nitrogen (DIN, including NO3 - and NH4 + ), dissolved organic nitrogen (DON) and δ15 N signatures of DIN collected at six sampling sites in the mountain region of Southwest China. These approaches include one quantitative approach running a Bayesian isotope mixing model (SIAR model) and five qualitative approaches based on in-situ survey (ISS), ratio of NH4 + /NO3 - (RN ), principal component analysis (PCA), canonical-correlation analysis (CCA) and stable isotope approach (SIA)...
June 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29909267/how-to-make-an-accurate-diagnosis-of-fetal-pyriform-sinus-fistula-in-utero-experience-at-a-single-medical-center-in-mainland-china
#17
Zequn Liu, Jin Han, Fang Fu, H S Liu, Qiu-Ming He, Wei Zhong, Hongying Wang, Xin Yang, Dongzhi Li, Can Liao
OBJECTIVE: The aim of this study was to make an accurate diagnosis of pyriform sinus fistula (PSF) for prenatal diagnosis. STUDY DESIGN: Medical records were reviewed for all 35 pyriform sinus fistula patients presenting between 2011 and 2017. Ultrasonography (US), fetal magnetic resonance imaging (MRI) and karyotyping were offered during gestation, while computer tomography (CT) and barium esophagography were performed after birth. RESULTS: Patients included 21 males (60%) and 14 females (40%) with a sex ratio of 1...
June 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909218/neuroimaging-in-criminal-trials-and-the-role-of-psychiatrists-expert-witnesses-a-case-study
#18
Georgia Martha Gkotsi, Jacques Gasser, Valérie Moulin
Various neuroscientific techniques are increasingly being used in criminal courts causing a vivid debate on the way that this kind of techniques will and should be used as scientific evidence. The role of experts in this context is important, since it is them that analyse, present, interpret and communicate the results of these techniques to the judges and the jury. In an attempt to contribute to the discussion about the role of the experts in criminal cases where neuroimaging evidence was introduced, we examined twenty seven cases from the US and Europe...
June 13, 2018: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29909192/prepuce-sparing-use-of-z-plasty-for-treatment-of-phimosis-and-scarred-foreskin
#19
Michael Benson, Moneer K Hanna
INTRODUCTION AND OBJECTIVES: The desire to preserve the prepuce is often based on cultural norms. Recently, the concept of "genital autonomy" has been invoked to delay circumcision (or any genital altering procedure) until the individual reaches maturity and can make his or her own decision. However, some uncircumcised boys develop one or more episodes of balanitis resulting in scarring of the prepuce and pathologic phimosis which is difficult to treat. Herein we report on the management of severe phimosis and preputial scarring using preputial Z-plasties...
June 8, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29909176/age-related-differences-in-striatal-medial-temporal-and-frontal-involvement-during-value-based-decision-processing
#20
Yu-Shiang Su, Jheng-Ting Chen, Yong-Jheng Tang, Shu-Yun Yuan, Anna C McCarrey, Joshua Oon Soo Goh
Appropriate neural representation of value and application of decision strategies are necessary to make optimal investment choices in real life. Normative human aging alters neural selectivity and control processing in brain regions implicated in value-based decision processing including striatal, medial temporal, and frontal areas. However, the specific neural mechanisms of how these age-related functional brain changes modulate value processing in older adults remain unclear. Here, young and older adults performed a lottery-choice functional magnetic resonance imaging experiment in which probabilities of winning different magnitudes of points constituted expected values of stakes...
May 21, 2018: Neurobiology of Aging
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