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https://www.readbyqxmd.com/read/28431442/-aortic-valve-stenosis-when-to-treat-interventionally-when%C3%A2-surgically
#1
Won-Keun Kim, Christian W Hamm
The mainstay for the current treatment of severe aortic stenosis includes surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI). In patients with high operative risk TAVI is established as first line therapy. New data on intermediate and low risk groups demonstrate at least non-inferiority of TAVI against SAVR, and in the near future a consistently rising number of transcatheter procedures may be anticipated. The purpose of this review is to outline the decision making process, hence to illustrate the diagnostic algorithm and to provide criteria for a differentiated approach against the background of recent data...
April 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28431439/-quality-of-and-attendance-at-healthy-child-clinics-in%C3%A2-germany
#2
Alexandra Weithase, Mandy Vogel, Henriette Kiep, Sarah Schwarz, Laura Meißner, Janine Herrmann, Kristin Rieger, Christiane Koch, Volker Schuster, Wieland Kiess
Background For several years the German healthy child clinics program has been a highly appreciated preventive measure and is subject to constant development. However, attendance depends on the families' sociodemographic situation. Findings are documented in a medical checkup booklet (the so-called Gelbes Heft). Currently, there is no procedure to use the data collected for epidemiological purposes nor to evaluate the pediatric prevention measures in Germany. Methods Between 2011 and 2016, we recruited 3480 study participants for our population-based cohort study LIFE Child in Leipzig...
April 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28431345/insights-into-targeting-young-male-drivers-with-anti-speeding-advertising-an-application-of-the-step-approach-to-message-design-and-testing-satmdt
#3
I Lewis, K M White, B Ho, B Elliott, B Watson
In Australia, young drivers aged 17-25 years comprise 13% of the population yet account for 22% of all road deaths with young males over-represented in such trauma. Speeding represents a major contributing factor and advertising campaigns have long focused on promoting anti-speeding messages in the effort to reduce drivers' speeds. Positioned within a larger program of research aimed at developing, piloting, and evaluating a range of theoretically-informed anti-speeding messages, the current study reports results relating to the final phase of the research, the evaluation...
April 18, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28431326/incidentally-detected-splenogonadal-fusion-in-a-laparoscopic-transabdominal-preperitoneal-hernia-repair-operation-a-case-report
#4
Yuichi Akama, Kimiyoshi Shimanuki, Shuji Asahi, Yohei Watanabe, Kazuhide Ko, Ryotaro Takano, Hodaka Amano, Takanori Kawaguchi, Eiji Uchida
INTRODUCTION: Splenogonadal fusion (SGF) is a rare congenital malformation in which the spleen is connected to the gonad. Few SGF cases have been reported in the English scientific literature, and we are unaware of any previous case reports of SGF with inguinal hernia by laparoscopic transabdominal preperitoneal hernia repair (TAPP). Here, we report a case of SGF that was incidentally detected during a TAPP procedure, with an uneventful postoperative course without complications. PRESENTATION OF CASE: A 76-year-old male presented with a 10-year history of left inguinal swelling...
April 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28431299/not-that-neglected-base-rates-influence-related-and-unrelated-judgments
#5
Michał Białek
It is claimed that people are unable (or unwilling) to incorporate prior probabilities into posterior assessments, such as their estimation of the likelihood of a person with characteristics typical of an engineer actually being an engineer given that they are drawn from a sample including a very small number of engineers. This paper shows that base rates are incorporated in classifications (Experiment 1) and, moreover, that base rates also affect unrelated judgments, such as how well a provided description of a person fits a stereotypical engineer (Experiment 2)...
April 17, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28431298/bioluminescence-emissions-of-female-fireflies-of-the-species-luciola-praeusta
#6
Mana Mohan Rabha, Upamanyu Sharma, Angana Goswami, Anurup Gohain Barua
Numerous investigations have been carried out on bioluminescence emissions from male fireflies. However, very few observations have been made on the emitted light from female specimens. Even in those, apart from observing responses from females to courtship flashes from conspecific males, detailed studies have not been performed. Here we present a first report on the light of female fireflies of the Indian species Luciola praeusta Kiesenwetter 1874 (Coleoptera:Lampyridae:Luciolinae). In the steady-state emission spectrum over the temperature range of 20-40°C, the peak wavelength is the same as, while the full width at half maximum is larger than, that of a male specimen of this species...
April 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28431278/intranasal-oxytocin-does-not-modulate-jumping-to-conclusions-in-schizophrenia-potential-interactions-with-caudate-volume-and-baseline-social-functioning
#7
Fernando Caravaggio, Philip Gerretsen, Wanna Mar, Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Julia Kim, Yusuke Iwata, Raihaan Patel, M Mallar Chakravarty, Gary Remington, Ariel Graff-Guerrero, Mahesh Menon
BACKGROUND: Patients with schizophrenia (SCZ) tend to sample less information when making a decision, jumping to conclusions (JTC) without sufficient evidence. This "JTC bias" may be a trait marker of the disease and may not improve with antipsychotic treatment. We conducted a double-blind, placebo-controlled trial to test whether intranasal oxytocin could reduce JTC in stable, medicated patients with SCZ and healthy controls (HCs). We also explored whether striatal volume, clinical symptoms, and baseline social functioning (SF) was related to JTC performance...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28431250/nuclear-proximity-of-mtr4-to-rna-exosome-restricts-dna-mutational-asymmetry
#8
Junghyun Lim, Pankaj Kumar Giri, David Kazadi, Brice Laffleur, Wanwei Zhang, Veronika Grinstein, Evangelos Pefanis, Lewis M Brown, Erik Ladewig, Ophélie Martin, Yuling Chen, Raul Rabadan, François Boyer, Gerson Rothschild, Michel Cogné, Eric Pinaud, Haiteng Deng, Uttiya Basu
The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA contributes to the development of immune and neural systems along with the progression of cancer. Because developmentally matured B cells undergo biologically programmed strand-specific DNA mutagenesis at focal DNA/RNA hybrid structures, they make a convenient system to investigate strand-specific mutagenesis mechanisms. We demonstrate that the sense and antisense strand DNA mutagenesis at the immunoglobulin heavy chain locus and some other regions of the B cell genome depends upon localized RNA processing protein complex formation in the nucleus...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431241/akt-pkb-signaling-navigating-the-network
#9
REVIEW
Brendan D Manning, Alex Toker
The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25 years ago and has been the focus of tens of thousands of studies in diverse fields of biology and medicine. There have been many advances in our knowledge of the upstream regulatory inputs into AKT, key multifunctional downstream signaling nodes (GSK3, FoxO, mTORC1), which greatly expand the functional repertoire of AKT, and the complex circuitry of this dynamically branching and looping signaling network that is ubiquitous to nearly every cell in our body...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431201/teaching-neuroanatomy-using-computer-aided-learning-what-makes-for-successful-outcomes
#10
Elena Svirko, Jane Mellanby
Computer-aided learning (CAL) is an integral part of many medical courses. The neuroscience course at Oxford University for medical students includes CAL course of neuroanatomy. CAL is particularly suited to this since neuroanatomy requires much detailed three-dimensional visualization, which can be presented on screen. The CAL course was evaluated using the concept of approach to learning. The aims of university teaching are congruent with the deep approach-seeking meaning and relating new information to previous knowledge-rather than to the surface approach of concentrating on rote learning of detail...
April 21, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28431190/higher-levels-of-submissive-behaviors-at-the-onset-of-the-pairing-process-of-rhesus-macaques-macaca-mulatta-are-associated-with-lower-risk-of-wounding-following-introduction
#11
Ori Pomerantz, Kate C Baker
Social housing of rhesus macaques (Macaca mulatta) is considered to be the cornerstone of behavioral management programs in biomedical facilities. However, it also involves the risk of socially inflicted trauma. The ability to avoid such trauma would contribute to the animals' well-being and alleviate staff's concerns, thus paving the path for more introductions. Here, we sought to address the conflict between the need to socially house rhesus macaques and the need to bring social wounding to a minimum by identifying behaviors expressed early in social introductions, that may serve as predictors of later wounding events...
April 21, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28431179/mirna-regulation-in-gliomas-usual-suspects-in-glial-tumorigenesis-and-evolving-clinical-applications
#12
Heather Ames, Marc K Halushka, Fausto J Rodriguez
In recent years, an increasing role for noncoding small RNAs (miRNA) has been uncovered in carcinogenesis. These oligonucleotides can promote degradation and/or inhibit translation of key mRNAs. Recent studies have also highlighted a possible role for miRNAs in adult and pediatric brain tumors, including high- and low-grade gliomas, medulloblastoma, ependymoma, and neoplasms associated with neurofibromatosis type 1. Gliomas represent the most common category of primary intraparenchymal brain tumors, and, for example, manipulation of signaling pathways, through inhibition of PTEN transcription appears to be an important function of miRNA dysregulation through miR-21, miR-106b, and miR-26a...
April 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28431172/quantitative-analysis-of-li-distributions-in-battery-material-li1-xfepo4-using-fe-m2-3-edge-and-valence-electron-energy-loss-spectra
#13
Shunsuke Kobayashi, Craig A J Fisher, Akihide Kuwabara, Yoshio Ukyo, Yuichi Ikuhara
The spatial distribution of Li ions in a lithium iron phosphate (Li1-xFePO4) single crystal after chemical delithiation is quantitatively investigated using Fe M2,3-edge and valence electron energy loss (EEL) spectroscopy techniques. Li contents between those of end-member compositions LiFePO4 and FePO4 are found to correspond to reproducible changes in Fe M2,3-edge and valence EEL spectra across an interface between LiFePO4 and FePO4 regions. Quantitative analysis of these changes is used to estimate the local valence states of Fe ions, from which the Li concentration in the intermediate phase can be deduced...
April 18, 2017: Microscopy
https://www.readbyqxmd.com/read/28431169/spa-ln-a-scoring-function-of-ligand-nucleic-acid-interactions-via-optimizing-both-specificity-and-affinity
#14
Zhiqiang Yan, Jin Wang
Nucleic acids have been widely recognized as potential targets in drug discovery and aptamer selection. Quantifying the interactions between small molecules and nucleic acids is critical to discover lead compounds and design novel aptamers. Scoring function is normally employed to quantify the interactions in structure-based virtual screening. However, the predictive power of nucleic acid-ligand scoring functions is still a challenge compared to other types of biomolecular recognition. With the rapid growth of experimentally determined nucleic acid-ligand complex structures, in this work, we develop a knowledge-based scoring function of nucleic acid-ligand interactions, namely SPA-LN...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28431168/identifying-new-susceptibility-genes-on-dopaminergic-and-serotonergic-pathways-for-the-framing-effect-in-decision-making
#15
Xiaoxue Gao, Jinting Liu, Pingyuan Gong, Junhui Wang, Wan Fang, Hongming Yan, Lusha Zhu, Xiaolin Zhou
The framing effect refers the tendency to be risk-averse when options are presented positively but be risk-seeking when the same options are presented negatively during decision-making. This effect has been found to be modulated by the serotonin transporter gene (SLC6A4) and the catechol-o-methyltransferase gene (COMT) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. The current study aimed to identify new genetic variations of genes on dopaminergic and serotonergic pathways that may contribute to individual differences in the susceptibility to framing...
April 19, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28431030/using-multivariate-base-rates-to-interpret-low-scores-on-an-abbreviated-battery-of-the-delis-kaplan-executive-function-system
#16
Justin E Karr, Mauricio A Garcia-Barrera, James A Holdnack, Grant L Iverson
Objective: Executive function consists of multiple cognitive processes that operate as an interactive system to produce volitional goal-oriented behavior, governed in large part by frontal microstructural and physiological networks. Identification of deficits in executive function in those with neurological or psychiatric conditions can be difficult because the normal variation in executive function test scores, in healthy adults when multiple tests are used, is largely unknown. This study addresses that gap in the literature by examining the prevalence of low scores on a brief battery of executive function tests...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28431021/patterns-of-genome-wide-diversity-and-population-structure-in-the-drosophila-athabasca-species-complex
#17
Karen M Wong Miller, Ryan R Bracewell, Michael B Eisen, Doris Bachtrog
The Drosophila athabasca species complex contains three recently diverged, prezygotically isolated semispecies (Western-Northern, Eastern-A, and Eastern-B) that are distributed across North America and share zones of sympatry. Inferences based on a handful of loci suggest that this complex might be an ideal system for studying the genetics of incipient speciation and the evolution of prezygotic isolating mechanisms, but patterns of differentiation have not been characterized systematically. Here, we assembled a draft genome for D...
April 14, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28431018/disulfide-bonds-enable-accelerated-protein-evolution
#18
Felix Feyertag, David Alvarez-Ponce
The different proteins of any proteome evolve at enormously different rates. What factors contribute to this variability, and to what extent, is still a largely open question. We hypothesized that disulfide bonds, by increasing protein stability, should make proteins' structures relatively independent of their amino acid sequences, thus acting as buffers of deleterious mutations and enabling accelerated sequence evolution. In agreement with this hypothesis, we observed that membrane proteins with disulfide bonds evolved 88% faster than those without disulfide bonds, and that extracellular proteins with disulfide bonds evolved 49% faster than those without disulfide bonds...
April 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28430984/adjunctive-use-of-anticoagulants-at-the-time-of-percutaneous-coronary-intervention-in-patients-with-an-acute-coronary-syndrome-treated-with-fondaparinux-a-multinational-retrospective-review
#19
Jill E Abell, Shiona M Laing, Tara C Barker, Elliott C Norry, Kathryn Starzyk, Shaun G Goodman, Mikael Dellborg, P Gabriel Steg, Robert P Giugliano
Aim: This retrospective chart review was designed to evaluate physician adherence to the prescribing information for fondaparinux regarding adjunctive anticoagulant use during percutaneous coronary intervention (PCI) in patients with an acute coronary syndrome (ACS). Methods and Results: Medical record abstractors at each site obtained information regarding the use of fondaparinux and adjunctive anticoagulants during PCI. Physician adherence to fondaparinux prescribing information regarding the administration of an adjunctive anticoagulant during PCI was estimated using generalized estimating equations...
April 18, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28430978/culture-matters-indigenizing-patient-safety-in-bhutan
#20
Rinchen Pelzang, Megan-Jane Johnstone, Alison M Hutchinson
Studies show that if quality of healthcare in a country is to be achieved, due consideration must be given to the importance of the core cultural values as a critical factor in improving patient safety outcomes. The influence of Bhutan's traditional (core) cultural values on the attitudes and behaviours of healthcare professionals regarding patient care are not known. This study aimed to explore the possible influence of Bhutan's traditional cultural values on staff attitudes towards patient safety and quality care...
April 17, 2017: Health Policy and Planning
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