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https://www.readbyqxmd.com/read/28823143/stent-thrombosis-and-optimal-duration-of-dual-antiplatelet-therapy-after-coronary-stenting-in-contemporary-practice
#1
Min Soo Cho, Duk-Woo Park
The introduction of drug-eluting stents (DES) in the practice of percutaneous coronary intervention (PCI) has substantially reduced angiographic and clinical restenosis but is associated with an increasing propensity for very late stent thrombosis (ST). Among several clinical, lesion, or procedure-related predictors of ST, early discontinuation of dual antiplatelet therapy (DAPT) is the most important factor for DES-associated late thrombosis; therefore, the optimal duration of DAPT is a major issue to be critically considered in the current DES era...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823097/epitope-mapping-of-histo-blood-group-antigens-bound-to-norovirus-vlps-using-std-nmr-experiments-reveals-fine-details-of-molecular-recognition
#2
Brigitte Fiege, Mila Leuthold, Francisco Parra, Kevin P Dalton, Peter J Meloncelli, Todd L Lowary, Thomas Peters
Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be critical for the infection process. Therefore, we have determined binding epitopes of synthetic type 1 to 6 blood group A- and B-tetrasaccharides binding to GII.4 human Norovirus virus like particles (VLPs) using STD NMR experiments. So far, little information is available from crystal structure analysis studies on the interactions of the reducing-end sugars with the protruding domain (P-domain) of the viral coat protein VP1...
August 19, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28823085/chromaffin-cells-as-a-model-to-evaluate-mechanisms-of-cell-death-and-neuroprotective-compounds
#3
REVIEW
Cristobal de Los Rios, Maria F Cano-Abad, Mercedes Villarroya, Manuela G López
In this review, we show how chromaffin cells have contributed to evaluate neuroprotective compounds with diverse mechanisms of action. Chromaffin cells are considered paraneurons, as they share many common features with neurons: (i) they synthesize, store, and release neurotransmitters upon stimulation and (ii) they express voltage-dependent calcium, sodium, and potassium channels, in addition to a wide variety of receptors. All these characteristics, together with the fact that primary cultures from bovine adrenal glands or chromaffin cells from the tumor pheochromocytoma cell line PC12 are easy to culture, make them an ideal model to study neurotoxic mechanisms and neuroprotective drugs...
August 19, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28823035/armored-dna-in-recombinant-baculoviruses-as-controls-in-molecular-genetic-assays
#4
Andrea Freystetter, Christian Paar, Herbert Stekel, Jörg Berg
The widespread use of molecular PCR-based assays in analytical and clinical laboratories brings about the need for test-specific, stable, and reliable external controls (EC) as well as standards and internal amplification controls (IC), in order to arrive at consistent test results. In addition, there is also a growing need to produce and provide stable, well-characterized molecular controls for quality assurance programs. In this study, we describe a novel approach to generate armored double-stranded DNA controls, which are encapsulated in baculovirus (BV) particles of the species Autographa californica multiple nucleopolyhedrovirus...
August 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#5
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28823018/prevalence-and-nature-of-potential-drug-drug-interactions-among-kidney-transplant-patients-in-a-german-intensive-care-unit
#6
Julia Amkreutz, Alexander Koch, Lukas Buendgens, Anja Muehlfeld, Christian Trautwein, Albrecht Eisert
Background Complex polypharmacotherapy makes kidney transplant patients vulnerable to drug-drug interactions (DDIs). Objective To study prevalence and nature of potential DDIs (pDDIs) in kidney transplant patients. Setting Internal medicine ICU, University Hospital RWTH Aachen. Method In this retrospective observational study, pDDIs were identified in the first week after transplant from 1999 to 2010. Patients aged at least 18 years with prescription of at least two drugs were included. Patients with incomplete data were excluded...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28822931/adherence-of-microplastics-to-soft-tissue-of-mussels-a-novel-way-to-uptake-microplastics-beyond-ingestion
#7
Prabhu Kolandhasamy, Lei Su, Jiana Li, Xiaoyun Qu, Khalida Jabeen, Huahong Shi
Microplastic pollution is recognized as an emerging threat to aquatic ecosystems. One of the main environmental risks associated with microplastics is their bioavailability to marine organisms. Up to date, ingestion has been widely accepted as the sole way for the animals to uptake microplastics. Nevertheless, microplastics have also been found in some organs which are not involved in the process of ingestion. We hypothesize that the animal might uptake microplastics through adherence in addition to ingestion...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822911/maullinia-braseltonii-sp-nov-rhizaria-phytomyxea-phagomyxida-a-cyst-forming-parasite-of-the-bull-kelp-durvillaea-spp-stramenopila-phaeophyceae-fucales
#8
Pedro Murúa, Franz Goecke, Renato Westermeier, Pieter van West, Frithjof C Küpper, Sigrid Neuhauser
Phytomyxea are obligate endoparasites of angiosperm plants and Stramenopiles characterised by a complex life cycle. Here Maullinia braseltonii sp. nov., an obligate parasite infecting the bull kelp Durvillaea (Phaeophyceae, Fucales) from the South-Eastern Pacific (Central Chile and Chiloe Island) and South-Western Atlantic (Falkland Islands, UK) is described. M. braseltonii causes distinct hypertrophies (galls) on the host thalli making it easily identifiable in the field. Sequence comparisons based on the partial 18S and the partial 18S-5...
July 13, 2017: Protist
https://www.readbyqxmd.com/read/28822900/supportive-care-pathway-functionalities-of-ehr-system-in-a-saudi-arabian-hospital
#9
Bakheet Aldosari
BACKGROUND: Electronic health record (EHR) is a data management system used in healthcare services. The stored medical information in EHR can be accessed and utilized by authorized users, which helps clinicians in making clinical decisions. Therefore, this study aims at comparing the embedded clinical guidelines or the supportive pathway functions as well as their compliance level in the two EMR systems, i.e. QuadraMed (QCPR) and BestCare. METHODS: A test vignette was used to evaluate the features, functions, performance, and output to assess the EHR clinical path way functionality of the QCPR and BestCare...
August 12, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28822898/beyond-dichotomies-m-others-structuring-and-the-development-of-toddlers-prosocial-behavior-across-cultures
#10
REVIEW
Joscha Kärtner
Basic elements of prosociality-(pro)social cognition, motivation, and prosocial behavior-emerge during the first and second year of life. These elements are rooted in biological predispositions and the developmental system is complemented by caregivers' structuring. By structuring, (m)others integrate toddlers' unrefined (pro)social sentiments and behavioral inclinations into coherent patterns and align toddlers' experience and behavior with the population's cultural model. These cultural models specify target states for appropriate affective, motivational and behavioral responses regarding toddlers' prosociality and these target states, in turn, inform (m)others' appraisal and guide their structuring...
August 5, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28822887/the-changing-diagnostic-pathway-for-lung-cancer-patients-in-shanghai-china
#11
REVIEW
Tao Jiang, Shengxiang Ren, Xuefei Li, Chunxia Su, Caicun Zhou, Mary O'Brien
Accumulating evidence suggest that patients with advanced non-small-cell lung cancer (NSCLC) and specific genomic alterations including epidermal growth factor receptor and microtubule-associated protein-like 4 anaplastic lymphoma kinase could significantly benefit from molecular-targeted therapies compared with chemotherapy. Recently, immunotherapy based on programmed cell death 1 (PD-1) and its ligand (PD-L1) blockade prolong survival in patients with advanced NSCLC, especially in those patients with positive expression of PD-L1 and when used in the first-line setting...
August 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28822884/with-directed-study-before-a-4-day-operating-room-management-course-trust-in-the-content-did-not-change-progressively-during-the-classroom-time
#12
Franklin Dexter, Richard H Epstein, Brenda G Fahy, Lyn M Van Swol
STUDY OBJECTIVE: A 4-day course in operating room (OR) management is sufficient to provide anesthesiologists with the knowledge and problem solving skills needed to participate in projects of the systems-based-practice competency. Anesthesiologists may need to learn fewer topics when the objective is, instead, limited to comprehension of decision-making on the day of surgery, We tested the hypothesis that trust in course content would not increase further after completion of topics related to OR decision-making on the day of surgery...
August 17, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28822863/an-x-ray-absorption-fine-structure-spectroscopy-study-of-metal-sorption-to-graphene-oxide
#13
Allison R Showalter, Thomas A Duster, Jennifer E S Szymanowski, Chongzheng Na, Jeremy B Fein, Bruce A Bunker
Remediation and prevention of environmental contamination by toxic metals is an ongoing issue. Additionally, improving water filtration systems is necessary to prevent toxic metals from circulating through the water supply. Graphene oxide (GO) is a highly sorptive material for a variety of heavy metals under different ionic strength conditions over a wide pH range, making it a promising candidate for use in metal adsorption from contaminated sites or in filtration systems. We present X-ray absorption fine structure (XAFS) spectroscopy results investigating the binding environment of Cd (II), U(VI) and Pb(II) ions onto multi-layered graphene oxide (MLGO)...
August 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822821/what-makes-journal-club-effective-a-survey-of-orthopaedic-residents-and-faculty
#14
Sean T Campbell, Jason R Kang, Julius A Bishop
BACKGROUND: Journal clubs play an important role in the education of orthopaedic surgery residents; however, there are sparse data available on the characteristics that make journal clubs effective. OBJECTIVE: The primary goal of this study was to determine the characteristics of effective journal clubs as identified by orthopaedic residents and faculty. We sought to compare the opinions of residents and faculty in order to identify areas that may benefit from future research and discussion...
August 16, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28822820/utility-of-3d-reconstruction-of-2d-liver-computed-tomography-magnetic-resonance-images-as-a-surgical-planning-tool-for-residents-in-liver-resection-surgery
#15
Caitlin T Yeo, Andrew MacDonald, Tamas Ungi, Andras Lasso, Diederick Jalink, Boris Zevin, Gabor Fichtinger, Sulaiman Nanji
OBJECTIVE: A fundamental aspect of surgical planning in liver resections is the identification of key vessel tributaries to preserve healthy liver tissue while fully resecting the tumor(s). Current surgical planning relies primarily on the surgeon's ability to mentally reconstruct 2D computed tomography/magnetic resonance (CT/MR) images into 3D and plan resection margins. This creates significant cognitive load, especially for trainees, as it relies on image interpretation, anatomical and surgical knowledge, experience, and spatial sense...
August 16, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28822812/determinants-of-thermostability-in-the-cytochrome-p450-fold
#16
REVIEW
Kurt L Harris, Raine E S Thomson, Silja J Strohmaier, Yosephine Gumulya, Elizabeth M J Gillam
Cytochromes P450 are found throughout the biosphere in a wide range of environments, serving a multitude of physiological functions. The ubiquity of the P450 fold suggests that it has been co-opted by evolution many times, and likely presents a useful compromise between structural stability and conformational flexibility. The diversity of substrates metabolized and reactions catalyzed by P450s makes them attractive starting materials for use as biocatalysts of commercially useful reactions. However, process conditions impose different requirements on enzymes to those in which they have evolved naturally...
August 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28822787/global-regional-and-national-deaths-prevalence-disability-adjusted-life-years-and-years-lived-with-disability-for-chronic-obstructive-pulmonary-disease-and-asthma-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#17
(no author information available yet)
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year...
August 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28822767/eurostemcell-a-european-infrastructure-for-communication-and-engagement-with-stem-cell-research
#18
REVIEW
Jan Barfoot, Kate Doherty, C Clare Blackburn
EuroStemCell is a large and growing network of organizations and individuals focused on public engagement with stem cells and regenerative medicine - a fluid and contested domain, where scientific, political, ethical, legal and societal perspectives intersect. Rooted in the European stem cell research community, this project has developed collaborative and innovative approaches to information provision and direct and online engagement, that reflect and respond to the dynamic growth of the field itself. EuroStemCell started as the communication and outreach component of a research consortium and subsequently continued as a stand-alone engagement initiative...
August 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28822751/using-multi-level-bayesian-lesion-symptom-mapping-to-probe-the-body-part-specificity-of-gesture-imitation-skills
#19
Elisabeth I S Achilles, Peter H Weiss, Gereon R Fink, Ellen Binder, Cathy J Price, Thomas M H Hope
Past attempts to identify the neural substrates of hand and finger imitation skills in the left hemisphere of the brain have yielded inconsistent results. Here, we analyse those associations in a large sample of 257 left hemisphere stroke patients. By introducing novel Bayesian methods, we characterise lesion symptom associations at three levels: the voxel-level, the single-region level (using anatomically defined regions), and the region-pair level. The results are inconsistent across those three levels and we argue that each level of analysis makes assumptions which constrain the results it can produce...
August 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28822748/systematical-exploration-of-transcription-factors-in-cardiomyocytes-against-hydrogen-peroxide-induced-oxidative-stress-by-danhong-injection
#20
Jingjing Zhang, Feifei Guo, Junying Wei, Minghua Xian, Shihuan Tang, Ye Zhao, Mingwei Liu, Lei Song, Ya Geng, Hongjun Yang, Chen Ding, Luqi Huang
Oxidative stress plays a vital role in many pathological processes of the cardiovascular diseases. However, the underlying mechanism remains unclear, especially on a transcription factor (TF) level. In this study, a new method, concatenated tandem array of consensus transcription factor response elements (catTFREs), and an Illumina-based RNA-seq technology were integrated and then combined with a network pharmacology strategy to systematically investigate the role of TFs in hydrogen peroxide (H2O2)-induced oxidative stress in cardiomyocytes; the damage was then rescued by Danhong injection (DHI), a Chinese standardized product approved for cardiovascular diseases treatment...
August 16, 2017: Free Radical Biology & Medicine
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