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https://www.readbyqxmd.com/read/29166721/-a-preliminary-study-on-the-relationship-between-idiopathic-arrhythmia-and-cardiac-magnetic-resonance-imaging-defined-cardiac-features-in-patients-with-straight-back-syndrome
#1
L Chen, X H Ma, L Zhao, R Bai, S N Li, L Wang, H Chen, Z M Fan, M W Lou, Y D Niu
Objective: To retrospectively analyze the potential correlation between cardiac magnetic resonance (CMR) imaging and clinical features and idiopathic arrhythmia in patients with straight back syndrome (SBS). Methods: Patients receiving CMR imaging examination from April 2015 to March 2016 at our department (n=1 432) were screened, 76 patients met the diagnosis criteria of flat chest (anteroposterior diameter/transthoracic diameter (APD/TTD) ratio<0.37 at the T8 vertebra). After excluding 33 patients with structural heart disease, 43 SBS patients were divided into two groups: SBS without obvious morphological change in the heart (group A, n=19) and SBS with morphological change of the heart (group B, n=24)...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166701/when-is-protection-from-impact-needed-for-the-face-as-well-as-the-eyes-in-occupational-environments
#2
Stephen J Dain, Rose Huang, Aimee Tiao, B Ralph Chou
BACKGROUND: The most commonly identified reason for requiring or using occupational eye and face protection is for protection against flying objects. Standards vary on what risk may require protection of the eyes alone and what requires protection for the whole face. Information on the minimum energy transfer for face damage to occur is not well-established. METHODS: The heads of pigs were used as the common model for human skin. A 6 mm steel ball projected at velocities between 45 and 135 m/s was directed at the face area...
November 22, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29166685/-evaluation-of-inpatient-conservative-management-of-acute-subacute-and-chronic-back-pain
#3
Ingo Haase, Kilian Haase, Bernd Kladny
Background Backache is very common in the German population. It is a common reason for people to seek medical advice and specific back pain programs have been developed. The intention of this study is to evaluate the short and long term effects of conservative management of back pain in a German general hospital. Outcomes of interest were pain intensity, interference in daily functions, physical functioning and health related quality of life. Patients and Methods We examined 1010 patients with acute, subacute and chronic back pain, admitted to inpatient nonsurgical interventional therapy in a German hospital between July 2013 and July 2015...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29166664/is-there-a-reasonable-excuse-for-not-providing-post-operative-analgesia-when-using-animal-models-of-peripheral-neuropathic-pain-for-research-purposes
#4
Sara Hestehave, Gordon Munro, Rie Christensen, Tina Brønnum Pedersen, Lars Arvastson, Philip Hougaard, Klas S P Abelson
INTRODUCTION: The induction of neuropathic pain-like behaviors in rodents often requires surgical intervention. This engages acute nociceptive signaling events that contribute to pain and stress post-operatively that from a welfare perspective demands peri-operative analgesic treatment. However, a large number of researchers avoid providing such care based largely on anecdotal opinions that it might interfere with model pathophysiology in the longer term. OBJECTIVES: To investigate effects of various peri-operative analgesic regimens encapsulating different mechanisms and duration of action, on the development of post-operative stress/welfare and pain-like behaviors in the Spared Nerve Injury (SNI)-model of neuropathic pain...
2017: PloS One
https://www.readbyqxmd.com/read/29166653/testing-the-applicability-of-a-benthic-foraminiferal-based-transfer-function-for-the-reconstruction-of-paleowater-depth-changes-in-rhodes-greece-during-the-early-pleistocene
#5
Yvonne Milker, Manuel F G Weinkauf, Jürgen Titschack, Andre Freiwald, Stefan Krüger, Frans J Jorissen, Gerhard Schmiedl
We present paleo-water depth reconstructions for the Pefka E section deposited on the island of Rhodes (Greece) during the early Pleistocene. For these reconstructions, a transfer function (TF) using modern benthic foraminifera surface samples from the Adriatic and Western Mediterranean Seas has been developed. The TF model gives an overall predictive accuracy of ~50 m over a water depth range of ~1200 m. Two separate TF models for shallower and deeper water depth ranges indicate a good predictive accuracy of 9 m for shallower water depths (0-200 m) but far less accuracy of 130 m for deeper water depths (200-1200 m) due to uneven sampling along the water depth gradient...
2017: PloS One
https://www.readbyqxmd.com/read/29166499/skin-disorders-in-renal-transplant-recipients-a-retrospective-study
#6
Pedro Miguel Clemente Garrido, João Borges-Costa
BACKGROUND: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. OBJECTIVES: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. METHODS: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166449/caesarean-birth-rates-in-public-and-privately-funded-hospitals-a-cross-sectional-study
#7
Bruna Dias Alonso, Flora Maria Barbosa da Silva, Maria do Rosário Dias de Oliveira Latorre, Carmen Simone Grilo Diniz, Debra Bick
OBJECTIVE: To examine maternal and obstetric factors influencing births by cesarean section according to health care funding. METHODS: A cross-sectional study with data from Southeastern Brazil. Caesarean section births from February 2011 to July 2012 were included. Data were obtained from interviews with women whose care was publicly or privately funded, and from their obstetric and neonatal records. Univariate and multivariate analyses were conducted to generate crude and adjusted odds ratios (OR) with 95% confidence intervals (95%CI) for caesarean section births...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166422/-unknown-title
#8
P Stokes, J Rimmer
BACKGROUND: Hereditary haemorrhagic telangiectasia (HHT) remains a difficult disease for the ENT specialist to manage. Affected patients often report recurrent epistaxis as the most debilitating symptom. The pathogenesis of the disease is due to genetic mutations affecting angiogenesis. For this reason, the anti-angiogenic therapy bevacizumab has gained popularity in the local treatment of epistaxis in patients with HHT. OBJECTIVE: A systematic review of the efficacy of bevacizumab in local treatment of epistaxis in patients with HHT based on epistaxis duration, frequency, severity and impact on quality of life...
November 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29166369/quickstats-percentage-of-visits-to-office-based-physicians-%C3%A2-by-adults-aged-%C3%A2-18-years-for-diabetes-mellitus-%C3%A2-by-sex-and-age-national-ambulatory-medical-care-survey-2015
#9
(no author information available yet)
In 2015, diabetes was a reason for 4.2% of visits by adults to office-based physicians. Men aged 18-44 years had a higher percentage of visits for diabetes compared with women aged 18-44 years (2.2% versus 0.4%, respectively). Both women and men aged 18-44 years had a lower percentage of visits for diabetes compared with adults aged 45-64 and ≥65 years.
November 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29166312/factors-associated-with-late-surgical-cancellations-in-pediatric-plastic-and-oral-surgery
#10
Usha E A Beijnen, Catherine Noonan Caillouette, Susan J Flath-Sporn, Reid A Maclellan, Karl Sanchez, Brian I Labow, John G Meara, Amir H Taghinia
BACKGROUND: Surgical cancellations that occur within 1 day of the procedure (ie, late cancellations) disrupt the efficiency of the operating room. The aim of the present study was to identify the factors associated with late cancellations in a tertiary pediatric surgical practice. METHODS: We reviewed the medical records of patients treated by plastic and oral surgery services at our institution from 2010 to 2015. We collected data pertaining to the timing and reasons for cancellation...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166308/an-evaluation-of-the-choice-for-contralateral-prophylactic-mastectomy-and-patient-concerns-about-recurrence-in-a-reconstructed-cohort
#11
Ian C Sando, Jessica I Billig, Shoshana W Ambani, Casey T Kraft, Kelley M Kidwell, Lin Zhong, Kevin C Chung, Adeyiza O Momoh
BACKGROUND: Rising contralateral prophylactic mastectomy rates are a subject of national concern. This study assessed (1) factors critical to patients when deciding on contralateral prophylactic mastectomy and (2) patients' quality of life related to concerns about recurrence after unilateral or bilateral breast reconstruction. METHODS: Patients with stage 0 to III breast cancer who underwent unilateral mastectomy or contralateral prophylactic mastectomy and breast reconstruction at a single institution between 2000 and 2012 were identified...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166302/hierarchical-semi-bayes-methods-for-misclassification-in-perinatal-epidemiology
#12
Richard F MacLehose, Lisa M Bodnar, Craig Meyer, Haitao Chu, Timothy L Lash
BACKGROUND: Validation data are used to estimate the extent of misclassification in epidemiologic studies. In the Penn MOMS cohort, prepregnancy BMI is subject to misclassification and validation data are available to estimate the extent of misclassification. We use these data to estimate the association between maternal prepregnancy body mass index and early preterm (<32 weeks) birth using a semi-Bayes hierarchical model allowing for more flexible adjustment for misclassification...
November 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/29166242/dynamism-of-an-astrocyte-in-vivo-perspectives-on-identity-and-function
#13
Kira E Poskanzer, Anna V Molofsky
Astrocytes are an abundant and evolutionarily conserved central nervous system cell type. Despite decades of evidence that astrocytes are integral to neural circuit function, it seems as though astrocytic and neuronal biology continue to advance in parallel to each other, to the detriment of both. Recent advances in molecular biology and optical imaging are being applied to astrocytes in new and exciting ways but without fully considering their unique biology. From this perspective, we explore the reasons that astrocytes remain enigmatic, arguing that their responses to neuronal and environmental cues shape form and function in dynamic ways...
November 20, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/29166220/does-the-cognitive-reflection-test-actually-capture-heuristic-versus-analytic-reasoning-styles-in-older-adults
#14
Christopher Hertzog, R Marit Smith, Robert Ariel
Background/Study Context: This study evaluated adult age differences in the original three-item Cognitive Reflection Test (CRT; Frederick, 2005, The Journal of Economic Perspectives, 19, 25-42) and an expanded seven-item version of that test (Toplak et al., 2013, Thinking and Reasoning, 20, 147-168). The CRT is a numerical problem-solving test thought to capture a disposition towards either rapid, intuition-based problem solving (Type I reasoning) or a more thoughtful, analytical problem-solving approach (Type II reasoning)...
November 22, 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/29166051/a-time-correlation-function-approach-to-nuclear-dynamical-effects-in-x-ray-spectroscopy
#15
Sven Karsten, Sergey I Bokarev, Saadullah G Aziz, Sergei D Ivanov, Oliver Kühn
Modern X-ray spectroscopy has proven itself as a robust tool for probing the electronic structure of atoms in complex environments. Despite working on energy scales that are much larger than those corresponding to nuclear motions, taking nuclear dynamics and the associated nuclear correlations into account may be of importance for X-ray spectroscopy. Recently, we have developed an efficient protocol to account for nuclear dynamics in X-ray absorption and resonant inelastic X-ray scattering spectra [Karsten et al...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166037/adenosine-triphosphate-diffusion-through-poly-ethylene-glycol-diacrylate-hydrogels-can-be-tuned-by-cross-link-density-as-measured-by-pfg-nmr
#16
Günter Majer, Alexander Southan
The diffusion of small molecules through hydrogels is of great importance for many applications. Especially in biological contexts, the diffusion of nutrients through hydrogel networks defines whether cells can survive inside the hydrogel or not. In this contribution, hydrogels based on poly(ethylene glycol) diacrylate with mesh sizes ranging from ξ = 1.1 to 12.9 nm are prepared using polymers with number-average molecular weights between Mn = 700 and 8000 g/mol. Precise measurements of diffusion coefficients D of adenosine triphosphate (ATP), an important energy carrier in biological systems, in these hydrogels are performed by pulsed field gradient nuclear magnetic resonance...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166021/differences-in-the-aspect-ratio-of-gold-nanorods-that-induce-defects-in-cell-membrane-models
#17
Paula M P Lins, Valeria Spolon Marangoni, Thiers M Uehara, Paulo Barbeitas Miranda, Valtencir Zucolotto, Juliana Cancino Bernardi
Understanding the interactions between biomolecules and nanomaterials is of great importance for many areas of nanomedicine and bioapplications. Although studies in this area have been performed, the interactions between cell membranes and nanoparticles are not fully understood. Here, we investigate the interactions that occur between the Langmuir monolayers of dipalmitoylphosphatidyl glycerol (DPPG) and dipalmitoylphosphatidyl choline (DPPC) with gold nanorods (NR) - with three aspect ratios - and gold nanoparticles...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29166018/discovery-of-small-molecule-inhibitors-of-ubiquitin-specific-protease-7-usp7-using-integrated-nmr-and-in-silico-techniques
#18
Paola Di Lello, Richard Pastor, Jeremy M Murray, Robert A Blake, Frederick Cohen, Terry D Crawford, Joy Drobnick, Jason Drummond, Lorna Kategaya, Tracy Kleinheinz, Till Maurer, Lionel Rouge, Xianrui Zhao, Ingrid Wertz, Chudi Ndubaku, Vickie Tsui
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53 and for this reason it has gained increasing attention as a potential oncology target for small molecule inhibitors. Herein we describe the biophysical, biochemical and computational approaches that led to the identification of 4-(2-aminopyridin-3-yl)-phenol compounds described by Kategaya et al.1 as specific inhibitors of USP7. Fragment based lead discovery (FBLD) by NMR combined with virtual screening and re-mining of biochemical high-throughput screening (HTS) hits led to the discovery of a series of ligands that bind in the "palm" region of the catalytic domain of USP7 and inhibit its catalytic activity...
November 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29165992/quantitative-chemical-analysis-at-the-nanoscale-using-the-ptir-technique
#19
Georg Ramer, Vladimir Aksyuk, Andrea Centrone
Photothermal induced resonance (PTIR), also known as AFM-IR, is a scanning probe technique that provides sample composition information with a lateral resolution down to 20 nm. Interest in PTIR stems from its ability to identify unknown samples at the nanoscale thanks, in first approximation, to the direct comparability of PTIR spectra with far-field infrared databases. The development of rapidly tuning quantum cascade lasers has increased the PTIR throughput considerably, making nanoscale hyper-spectral imaging within a reasonable timeframe possible...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29165901/influence-of-ventral-tegmental-area-input-on-cortico-subcortical-networks-underlying-action-control-and-decision-making
#20
Anja Richter, Oliver Gruber
It is argued that the mesolimbic system has a more general function in processing all salient events, including and extending beyond rewards. Saliency was defined as an event that is unexpected due to its frequency of occurrence and elicits an attentional-behavioral switch. Using functional magnetic resonance imaging (fMRI), signals were measured in response to the modulation of salience of rewarding and nonrewarding events during a reward-based decision making task, the so called desire-reason dilemma paradigm (DRD)...
November 22, 2017: Human Brain Mapping
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