Eleanor J Molloy, Mohamed El-Dib, Sandra E Juul, Manon Benders, Fernando Gonzalez, Cynthia Bearer, Yvonne W Wu, Nicola J Robertson, Tim Hurley, Aoife Branagan, C Michael Cotten, Sidhartha Tan, Abbot Laptook, Topun Austin, Khorshid Mohammad, Elizabeth Rogers, Karen Luyt, Sonia Bonifacio, Janet S Soul, Alistair J Gunn
Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven beneficial, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. There is therefore a critical need to find additional pharmacological and non-pharmacological interventions that improve the outcomes for these children. There are many potential candidates; however, it is unclear whether these interventions have additional benefits when used with TH...
June 2023: Pediatric Research