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High B12

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https://www.readbyqxmd.com/read/28089775/degenerative-effects-of-cobalt-chloride-treatment-on-neurons-and-microglia-in-a-porcine-retina-organ-culture-model
#1
S Kuehn, J Hurst, F Rensinghoff, T Tsai, S Grauthoff, Y Satgunarajah, H B Dick, S Schnichels, S C Joachim
In order to understand the pathological processes of retinal diseases, experimental models are necessary. Cobalt, as part of the vitamin B12 complex, is important for neuronal integrity. However, it is known that high quantities of cobalt induce cytotoxic mechanisms via hypoxia mimicry. Therefore, we tested the degenerative effect of cobalt chloride (CoCl2) on neurons and microglia in a porcine retina organ culture model. Organotypic cultures of porcine retinas were cultured and treated with different concentrations of CoCl2 (0, 100, 300 and 500 μM) for 48 h...
January 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28074329/dietary-adequacy-of-egyptian-children-with-autism-spectrum-disorder-compared-to-healthy-developing-children
#2
Nagwa A Meguid, Mona Anwar, Geir Bjørklund, Adel Hashish, Salvatore Chirumbolo, Maha Hemimi, Eman Sultan
Although the etiology and pathology of autism spectrum disorder (ASD) is still poorly understood, a number of environmental, anthropological, neurobiological and genetic factors have been related to the pathophysiology of ASD, even the impact of oxidative stress response related to the environment and nutrition intake. Usual recommended dietary habits are based on the combination of behavioral and dietary or nutraceutical interventions together with pharmacotherapy. Investigations about a reliable relationship between diet and ASD are still lacking...
January 10, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28069173/periconceptional-maternal-biomarkers-of-one-carbon%C3%A2-metabolism-and-embryonic-growth-trajectories-the-rotterdam-periconceptional-cohort-predict-study
#3
Francesca Parisi, Melek Rousian, Anton H J Koning, Sten P Willemsen, Irene Cetin, Eric A P Steegers, Régine P M Steegers-Theunissen
OBJECTIVE: To study the associations between the periconceptional maternal biomarkers of one-carbon metabolism and embryonic growth. DESIGN: Prospective, periconceptional hospital-based birth cohort. SETTING: Tertiary medical care center. PATIENT(S): Between 2010 and 2014, 236 women with early singleton ongoing pregnancies that resulted in 139 strictly dated spontaneous pregnancies and 97 pregnancies conceived after assisted reproductive technology...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28057043/rapid-healing-of-a-patient-with-dramatic-subacute-combined-degeneration-of-spinal-cord-a-case-report
#4
Florian C Roessler, Stephanie Wolff
BACKGROUND: Prevalence of cobalamin deficiency is high especially in older patients and an immediate therapy start is necessary to prevent irreversible neurological damages. Unfortunately, the diagnosis of cobalamin deficiency is difficult and at present, there is no consensus for diagnosis of this deficiency. Therefore, we aim to elucidate a meaningful diagnostic pathway by a case report with an initially misleading medical history. CASE PRESENTATION: A 57 year-old Caucasian man suffering from dramatic myelosis of the cervical posterior columns...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28055029/gastrointestinal-transcriptomic-response-of-metabolic-vitamin-b12-pathways-in-roux-en-y-gastric-bypass
#5
Priscila Sala, Giliane Belarmino, Raquel S Torrinhas, Natasha M Machado, Danielle C Fonseca, Graziela R Ravacci, Robson K Ishida, Ismael F M S Guarda, Eduardo G de Moura, Paulo Sakai, Marco A Santo, Ismael D C G da Silva, Claudia C A Pereira, Angela F Logullo, Steven Heymsfield, Daniel Giannella-Neto, Dan L Waitzberg
OBJECTIVES: Vitamin B12 (B12) deficiency after Roux-en-Y gastric bypass (RYGB) is highly prevalent and may contribute to postoperative complications. Decreased production of intrinsic factor owing to gastric fundus removal is thought to have a major role, but other components of B12 metabolism may also be affected. We evaluated changes in the expression levels of multiple B12 pathway-encoding genes in gastrointestinal (GI) tissues to evaluate the potential roles in contributing to post-RYGB B12 deficiency...
January 5, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28025528/elevated-plasma-vitamin-b12-concentrations-are-independent-predictors-of-in-hospital-mortality-in-adult-patients-at-nutritional-risk
#6
Silvia Cappello, Emanuele Cereda, Mariangela Rondanelli, Catherine Klersy, Barbara Cameletti, Riccardo Albertini, Daniela Magno, Marilisa Caraccia, Annalisa Turri, Riccardo Caccialanza
Background: Elevated plasma vitamin B12 concentrations were identified as predictors of mortality in patients with oncologic, hepatic and renal diseases, and in elderly and critically ill medical patients. The association between vitamin B12 concentrations and in-hospital mortality in adult patients at nutritional risk has not been assessed. Methods: In this five-year prospective study, we investigated whether high vitamin B12 concentrations (>1000 pg/mL) are associated with in-hospital mortality in 1373 not-bed-ridden adult patients at nutritional risk (Nutrition Risk Index <97...
December 23, 2016: Nutrients
https://www.readbyqxmd.com/read/28024829/implication-of-homocysteine-in-diabetes-and-impact-of-folate-and-vitamin-b12-in-diabetic-population
#7
REVIEW
M Tahir Mursleen, Samreen Riaz
Diabetes mellitus is an acutely debilitating ailment affecting a large population of the world. At present, over 415 million people around the world including 7 million people in Pakistan suffering from diabetes. Homocysteine is an amino acid that is inversely related to vitamin B12 and folate, and raised level of homocysteine is implicated in many adverse health conditions. In this study, the potential role of homocysteine in diabetes and the epidemiology of hyperhomocysteinaemia, and vitamin B12 and folate deficiency is reviewed along with the impact of folate and vitamin B12 in regulation of homocysteine level...
December 13, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27993287/addition-of-vitamin-b12-to-exercise-training-improves-cycle-ergometer-endurance-in-advanced-copd-patients-a-randomized-and-controlled-study
#8
Fernanda Viana Paulin, Alessandro Moura Zagatto, Gaspar R Chiappa, Paulo de Tarso Müller
Vitamin B12 is essential in the homocysteine, mitochondrial, muscle and hematopoietic metabolisms, and its effects on exercise tolerance and kinetics adjustments of oxygen consumption (V'O2p) in rest-to-exercise transition in COPD patients are unknown. This randomized, double-blind, controlled study aimed to verify a possible interaction between vitamin B12 supplementation and these outcomes. After recruiting 69 patients, 35 subjects with moderate-to-severe COPD were eligible and 32 patients concluded the study, divided into four groups (n = 8 for each group): 1...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27982368/nutrition-situation-in-latin-america-and-the-caribbean-current-scenario-past-trends-and-data-gaps
#9
Luis Galicia, Rubén Grajeda, Daniel López de Romaña
Objective: To determine the current nutritional status in Latin America and the Caribbean (LAC) and identify data gaps and trends in nutrition surveillance. Methods: A systematic Internet search was conducted to identify official sources that allowed for monitoring of LAC countries' nutritional status, including progress toward World Health Organization Global Nutrition Targets 2025. Reports from national nutrition surveillance systems and reports on nationally representative surveys were collected and collated to 1) analyze nutritional status, based on life-course anthropometric indicators and biomarkers, and 2) identify gaps in data availability and trends in nutritional deficiencies...
August 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27959349/an-unusual-cause-of-falls-in-a-young-woman
#10
I Sleeman, L Wiblin, D Burn
Nitrous oxide is commonly used as an analgesic and anaesthetic agent. Nitrous oxide is also in use in industry as an aerosol propellant and is now recognised as a recreational drug whose use is growing, especially among the young. Nitrous oxide from whipped cream canisters is inhaled to produce a dissociative, intoxicated state. Nitrous oxide is known to inactivate vitamin B12 via oxidation, which can precipitate a demyelinating myelopathy akin to the classical B12 deficiency syndrome, subacute combined degeneration of the spinal cord...
September 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27941357/nutrient-deficiencies-prior-to-bariatric-surgery
#11
Lori R Roust, John K DiBaise
PURPOSE OF REVIEW: The purpose of this review is to provide an update of recent additions to our understanding of the prevalence of nutrient deficiencies and the potential role of preoperative weight loss in contributing to these deficiencies in obese individuals planning to undergo bariatric surgery. RECENT FINDINGS: Recent reports that have included bariatric surgery candidates from sites around the world have shown consistent deficiencies in a variety of nutrients...
December 9, 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27935592/molecular-insights-into-a-dinoflagellate-bloom
#12
Weida Gong, Jamie Browne, Nathan Hall, David Schruth, Hans Paerl, Adrian Marchetti
In coastal waters worldwide, an increase in frequency and intensity of algal blooms has been attributed to eutrophication, with further increases predicted because of climate change. Yet, the cellular-level changes that occur in blooming algae remain largely unknown. Comparative metatranscriptomics was used to investigate the underlying molecular mechanisms associated with a dinoflagellate bloom in a eutrophied estuary. Here we show that under bloom conditions, there is increased expression of metabolic pathways indicative of rapidly growing cells, including energy production, carbon metabolism, transporters and synthesis of cellular membrane components...
December 9, 2016: ISME Journal
https://www.readbyqxmd.com/read/27932499/genetic-variation-in-one-carbon-metabolism-and-changes-in-metabolic-parameters-in-first-episode-schizophrenia-patients
#13
Błażej Misiak, Łukasz Łaczmański, Natalia Kinga Słoka, Elżbieta Szmida, Ryszard Ślęzak, Patryk Piotrowski, Andrzej Kiejna, Dorota Frydecka
BACKGROUND: In this study, we aimed to investigate the effects of polymorphisms in genes encoding 1-carbon metabolism enzymes on differential development of metabolic parameters during 12 weeks of treatment with second-generation antipsychotics in first-episode schizophrenia patients. METHODS: The following polymorphisms in 1-carbon metabolism genes were genotyped: MTHFR (C677T and A1298C), MTHFD1 (G1958A), MTRR (A66G), and BHMT (G742A). A broad panel of metabolic parameters including body mass index, waist circumference, total cholesterol low and high density lipoproteins, triglycerides, homocysteine, folate, and vitamin B12 was determined...
December 8, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27931189/adaptation-of-propionibacterium-freudenreichii-to-long-term-survival-under-gradual-nutritional-shortage
#14
Flavia Figueira Aburjaile, Marine Rohmer, Hugues Parrinello, Marie-Bernadette Maillard, Eric Beaucher, Gwénaële Henry, Aurélie Nicolas, Marie-Noëlle Madec, Anne Thierry, Sandrine Parayre, Stéphanie-Marie Deutsch, Muriel Cocaign-Bousquet, Anderson Miyoshi, Vasco Azevedo, Yves Le Loir, Hélène Falentin
BACKGROUND: Propionibacterium freudenreichii is an Actinobacterium widely used in the dairy industry as a ripening culture for Swiss-type cheeses, for vitamin B12 production and some strains display probiotic properties. It is reportedly a hardy bacterium, able to survive the cheese-making process and digestive stresses. RESULTS: During this study, P. freudenreichii CIRM-BIA 138 (alias ITG P9), which has a generation time of five hours in Yeast Extract Lactate medium at 30 °C under microaerophilic conditions, was incubated for 11 days (9 days after entry into stationary phase) in a culture medium, without any adjunct during the incubation...
December 8, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27926557/long-term-quality-of-life-of-patients-with-permanent-end-ileostomy-results-of-a-nationwide-cross-sectional-survey
#15
Tobias S Schiergens, Verena Hoffmann, Tamara N Schobel, Gerhard H Englert, Martin E Kreis, Wolfgang E Thasler, Jens Werner, Michael S Kasparek
BACKGROUND: Patients with permanent end ileostomy are at high risk for detrimental stomal effects on their quality of life. However, little is known about the long-term quality of life of these patients. OBJECTIVE: The purpose of this study was to assess long-term quality of life in patients with permanent end ileostomy. DATA SOURCES: Registration at the German self-help organization ILCO was used for this study. STUDY SELECTION: Selection included a cross-sectional survey of 1434 patients with permanent end ileostomy...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27919754/neutralization-takes-precedence-over-igg-or-iga-isotype-related-functions-in-mucosal-hiv-1-antibody-mediated-protection
#16
Rena D Astronomo, Sampa Santra, Lamar Ballweber-Fleming, Katharine G Westerberg, Linh Mach, Tiffany Hensley-McBain, Laura Sutherland, Benjamin Mildenberg, Georgeanna Morton, Nicole L Yates, Gregory J Mize, Justin Pollara, Florian Hladik, Christina Ochsenbauer, Thomas N Denny, Ranjit Warrier, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Guido Ferrari, George M Shaw, Shi-Mao Xia, Hua-Xin Liao, David C Montefiori, Georgia D Tomaras, Barton F Haynes, M Juliana McElrath
HIV-1 infection occurs primarily through mucosal transmission. Application of biologically relevant mucosal models can advance understanding of the functional properties of antibodies that mediate HIV protection, thereby guiding antibody-based vaccine development. Here, we employed a human ex vivo vaginal HIV-1 infection model and a rhesus macaque in vivo intrarectal SHIV challenge model to probe the protective capacity of monoclonal broadly-neutralizing (bnAb) and non-neutralizing Abs (nnAbs) that were functionally modified by isotype switching...
December 2016: EBioMedicine
https://www.readbyqxmd.com/read/27919463/newer-anti-epileptic-drugs-vitamin-status-and-neuropathy-a-cross-sectional-analysis
#17
V Cahill, D McCorry, I Soryal, Y A Rajabally
OBJECTIVE: Whether new antiepileptic drugs (AEDs) may result in neuropathy is unknown but possible given their effects on vitamin metabolism. This analysis aimed to determine frequency and correlates of neuropathy in subjects treated with new AEDs in relation to drug used, length of exposure and serum vitamin B12 and folate levels. METHODS: We performed a cross-sectional study of 52 consecutive epileptic subjects. Presence of neuropathy was determined using the Utah Early Neuropathy Score (UENS)...
December 2, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27916242/the-effect-of-pregabalin-and-methylcobalamin-combination-on-the-chronic-postthoracotomy-pain-syndrome
#18
Serda Kanbur Metin, Burhan Meydan, Serdar Evman, Talha Dogruyol, Volkan Baysungur
BACKGROUND: Chronic postthoracotomy pain (CPTP) consists of different types of pain. Some characteristics of CPTP are the same as those of recognized neuropathic pain syndromes. We aimed to determine the safety and efficacy of pregabalin and methylcobalamin combination (PG-B12) in comparison with diclofenac potassium (DP) in patients with CPTP. METHODS: One hundred consecutive patients with CPTP after posterolateral/lateral thoracotomy were prospectively randomly assigned and evaluated...
December 1, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27904562/hyperhomocysteinemia-low-vitamin-b12-and-low-folic-acid-are-risk-factors-of-cerebral-vascular-thrombosis-in-northwest-iran
#19
Ali Akbar Taheraghdam, Nooriyeh Dalirakbari, Mohammad Khalili, Madjid Soltani, Saeid Sadeghieh Ahari
BACKGROUND: Cerebral vascular thrombosis (CVT) is the thrombosis of intracranial and sinuses. The aim of this is to estimate of risk of low folic acid, low vitamin B12, and hyperhomocysteinemia (hyper-Hcys) for CVT. MATERIALS AND METHODS: A total of 24 patients with CVT and 36 healthy controls participated in a cross-sectional case-control study. The deficient levels of folic acid and vitamin B12 defined as <10(th) percentile of folic acid and vitamin B12 level and hyper-Hcys was defined as >90(th) percentile of homocysteine of control group...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27885335/rapid-synthesis-of-redox-active-dodecaborane-b12-or-12-clusters-under-ambient-conditions
#20
Alex I Wixtrom, Yanwu Shao, Dahee Jung, Charles W Machan, Shaunt N Kevork, Elaine A Qian, Jonathan C Axtell, Saeed I Khan, Clifford P Kubiak, Alexander M Spokoyny
We have developed a fast and efficient route to obtain perfunctionalized ether-linked alkyl and benzyl derivatives of the closo-[B12(OH)12](2-) icosahedral dodecaborate cluster via microwave-assisted synthesis. These icosahedral boron clusters exhibit three-dimensional delocalization of the cage-bonding electrons, tunable photophysical properties, and a high degree of stability in air in both solid and solution states. A series of closo-[B12(OR)12](2-), hypocloso-[B12(OR)12](1-) and hypercloso-[B12(OR)12](0) clusters have been prepared with reaction times ranging from hours to several minutes...
May 1, 2016: Inorganic Chemistry Frontiers
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