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https://www.readbyqxmd.com/read/29150289/the-cause-of-multiple-sclerosis-is-autoimmune-attack-of-adenosyltransferase-thereby-limiting-adenosylcobalamin-production
#1
J L Boucher
The pathogenesis of multiple sclerosis (MS) begins with an infection by a bacterium from the class of bacteria that produce and utilize adenosylcobalamin (AdoCbl) and possess an adenosyl transferase enzyme (ATR); these bacteria are the exogenous antigens that cause MS. Human ATR is homologous to bacterial ATR and B cells produce anti-ATR antibodies as an autoimmune response thereby reducing the concentration of ATR and thus limiting production of AdoCbl, one of the two bioactive forms of vitamin B12. The next step in MS pathogenesis is a period of subclinical AdoCbl deficiency over a period of many years resulting in production of odd-carbon-number fatty acids that are incorporated into myelin rendering it antigenic...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29143127/decreased-serum-vitamin-b12-and-vitamin-d-levels-affect-sleep-quality-in-children-with-familial-mediterranean-fever
#2
Rabia Miray Kisla Ekinci, Sibel Balci, Mahir Serbes, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz
Familial Mediterranean fever is an autoinflammatory disorder characterized by recurrent fever and serositis. We aimed to describe serum vitamin B12 and vitamin D levels and their correlation with self-reported sleep quality of pediatric FMF patients. Sixty-three children with FMF were enrolled to the study. Information on sleep quality was obtained using self-administration of Pittsburg Sleep Quality Index (PSQI). The patients were divided into subgroups depending on vitamin D serum concentrations: ≥ 20 and < 20 ng/ml...
November 15, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29129231/the-association-between-the-index-of-nutritional-quality-inq-and-breast-cancer-and-the-evaluation-of-nutrient-intake-of-breast-cancer-patients-a-case-control-study
#3
Farhad Vahid, Mahshid Hatami, Mahya Sadeghi, Fatemeh Ameri, Zeinab Faghfoori, Sayed Hossein Davoodi
OBJECTIVE: Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. In Iran, the risk for BrCa is 1 in 35 and each year, 8000 new patients have been diagnosed with BrCa. Studies have shown that dietary components are implicated in the etiology of BrCa. The Index of Nutritional Quality (INQ) is a method of quantitative and qualitative analysis of single foods, meals, and diets. The aim of this study was to determine the usefulness of INQs in predicting BrCa risk...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29121493/prevalence-of-consumption-and-nutritional-content-of-breakfast-meal-among-adolescents-from-the-brazilian-national-dietary-survey
#4
Jaqueline L Pereira, Michelle A de Castro, Sinead Hopkins, Carolyn Gugger, Regina M Fisberg, Mauro Fisberg
OBJECTIVE: To estimate the prevalence of breakfast consumption and describe the foods and nutrients consumed at this meal and throughout the day by Brazilian adolescents. METHOD: A total of 7276 adolescents aged 10-19 years were evaluated in the Brazilian National Dietary Survey 2008-9, a population-based cross-sectional study. Individuals' information was collected at home. Dietary data were obtained by two food records. Breakfast was defined as the first eating occasion of the day that occurred between 6 and 9:59am...
November 6, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29120005/peripheral-neuropathy-due-to-recreational-use-of-nitrous-oxide-presenting-after-an-ankle-sprain-with-foot-drop
#5
Jackson A Middleton, John A Roffers
A 22-year-old man was referred for orthopedic follow-up after an ankle injury. Initial evaluation in urgent care included radiographs with negative findings. After a delayed presentation, a course of functional treatment was recommended. Subsequently, he developed a deep venous thrombosis and pulmonary emboli. He was found to be factor V Leiden deficient and was fully anticoagulated on warfarin. Later reevaluation revealed a steppage gait and foot drop. Electrodiagnostic studies (ie, electromyography and nerve conduction studies) revealed a severe peripheral polyneuropathy...
November 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/29110539/nutritional-and-bioactive-compounds-of-commercialized-algae-powders-used-as-food-supplements
#6
Ginés B Martínez-Hernández, Noelia Castillejo, María Del M Carrión-Monteagudo, Francisco Artés, Francisco Artés-Hernández
The main nutritional/bioactive compounds (protein; aminoacids, AA; fucose; minerals; vitamins B12 and C; and total phenolic content, TPC) of nine commercial algae powders, used as food supplements, were studied. Undaria pinnatifida showed the highest protein/aminoacid contents (51.6/54.4 g 100 g(-1)). Among brown macroalgae, Himanthalia elongata showed the highest fucose content (26.3 g kg(-1)) followed by Laminaria ochroleuca (22.5 g kg(-1)). Mineral contents of 15-24% were observed in the algae, being particularly excellent sources of iodine (69...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/29104633/echinocystic-acid-ameliorates-hyperhomocysteinemia-induced-vascular-endothelial-cell-injury-through-regulating-nf-%C3%AE%C2%BAb-and-cyp1a1
#7
Chuan-Feng Huang, Wei-Na Wang, Cheng-Cao Sun, Yu-Qing Wang, Ling Li, Yin Li, De-Jia Li
The present study investigated the role of echinocystic acid (EA) on the expression of nuclear factor (NF)-κB and cytochrome P450 1A1 (CYP1A1), and aortic morphology, in a rat model of hyperhomocysteinemia (Hhcy). A total of 50 Sprague Dawley rats were randomly divided into five groups as follows: Normal control (NC), model control (MC), vitamin control (VC; folic acid 1 mg/kg + vitamin B2 2 mg/kg + vitamin B12 10u g/kg), EA1 (20 mg/kg EA) and EA2 (40 mg/kg EA). Plasma homocysteine (Hcy) levels were determined via high performance liquid chromatography, and the morphology of the aorta was investigated using hematoxylin and eosin staining...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29092063/obesity-hyperhomocysteinaemia-and-risk-of-chronic-kidney-disease-a-population-based-study
#8
Shih-Han Lai, Yi-Wen Tsai, Yi-Chuan Chen, Shy-Shin Chang
Background: Obesity is associated with increased risk of cardiovascular disease and chronic kidney disease (CKD). Hyperhomocysteinaemia refers to increased oxidative stress and has been associated with the risk of CKD. Objectives: We investigated the association among body mass index (BMI), homocysteine level and impaired renal function in a Taiwanese adult population. Methods: This was a retrospective cross-sectional study involving 24826 subjects who underwent a health check-up from January 2013 to December 2015...
October 28, 2017: Family Practice
https://www.readbyqxmd.com/read/29083449/high-serum-folate-is-associated-with-brain-atrophy-in-older-diabetic-people-with-vitamin-b12-deficiency
#9
Y Deng, D Wang, K Wang, T Kwok
Previous studies have reported the adverse cognitive effects of high folate status in older individuals with vitamin B12 (VB12) deficiency. Thus, the aim of this study was to investigate how high serum folate and VB12 deficiency could collaboratively aggravate neuronal degeneration. In total, 146 older non-demented diabetic individuals with an average age of 75 ± 3.9 were recruited. VB12 deficiency and high folate status were based on high serum methylmalonic acid (MMA) concentrations (> 0.3 μmol/L) and the serum folate concentration being in the top tertile (> 31...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29075248/the-exometabolome-of-two-model-strains-of-the-roseobacter-group-a-marketplace-of-microbial-metabolites
#10
Gerrit Wienhausen, Beatriz E Noriega-Ortega, Jutta Niggemann, Thorsten Dittmar, Meinhard Simon
Recent studies applying Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) showed that the exometabolome of marine bacteria is composed of a surprisingly high molecular diversity. To shed more light on how this diversity is generated we examined the exometabolome of two model strains of the Roseobacter group, Phaeobacter inhibens and Dinoroseobacter shibae, grown on glutamate, glucose, acetate or succinate by FT-ICR-MS. We detected 2,767 and 3,354 molecular formulas in the exometabolome of each strain and 67 and 84 matched genome-predicted metabolites of P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29054650/vitamin-b12-effects-on-chlorinated-methanes-degrading-microcosms-dual-isotope-and-metabolically-active-microbial-populations-assessment
#11
Diana Rodríguez-Fernández, Clara Torrentó, Miriam Guivernau, Marc Viñas, Daniel Hunkeler, Albert Soler, Cristina Domènech, Mònica Rosell
Field-derived anoxic microcosms were used to characterize chloroform (CF) and carbon tetrachloride (CT) natural attenuation to compare it with biostimulation scenarios in which vitamin B12 was added (B12/pollutant ratio of 0.01 and 0.1) by means of by-products, carbon and chlorine compound-specific stable-isotope analysis, and the active microbial community through 16S rRNA MiSeq high-throughput sequencing. Autoclaved slurry controls discarded abiotic degradation processes. B12 catalyzed CF and CT biodegradation without the accumulation of dichloromethane, carbon disulphide, or CF...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29053883/pharmacokinetics-of-inorganic-cobalt-and-a-vitamin-b12-supplement-in-the-thoroughbred-horse-differentiating-cobalt-abuse-from-supplementation
#12
L L Hillyer, Z Ridd, S Fenwick, P Hincks, S W Paine
BACKGROUND: Whilst cobalt is an essential micronutrient for vitamin B12 synthesis in the horse, at supra-physiological concentrations it has been shown to enhance performance in humans and rats and there is evidence that its administration in high doses to horses poses a welfare threat. Animal sport regulators currently control cobalt abuse via international race day thresholds, but since cobalt may be present in physiological concentrations this work was initiated to explore means of potentially adding to application of those thresholds...
October 20, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29048238/superiority-of-a-vitamin-b12-containing-emollient-compared-to-a-standard-emollient-in-the-maintenance-treatment-of-mild-to-moderate-plaque-psoriasis
#13
Ester Del Duca, Francesca Farnetani, Nathalie De Carvalho, Ugo Bottoni, Giovanni Pellacani, Steven P Nisticò
Psoriasis is a chronic inflammatory skin disease affecting 2%-3% of the population. The wide range of drugs currently available for its treatment could be associated, in the long term, with organ toxicity and adverse events, thus, clinical monitoring throughout treatment is required. This investigator-initiated trial (IIT) evaluated the efficacy and the safety of a vitamin B12-containing ointment in comparison with glycerol-petrolatum-based emollient cream used twice a day to treat mild-to-moderate plaque psoriasis for a period over 12 weeks followed by a wash-out observation period of 4 weeks...
October 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29045954/-pulmonary-arterial-hypertension-as-leading-manifestation-of-methylmalonic-aciduria-clinical-characteristics-and-gene-testing-in-15-cases
#14
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29041832/enhanced-vitamin-b12-production-in-an-innovative-lupin-tempeh-is-due-to-synergic-effects-of-rhizopus-and-propionibacterium-in-cofermentation
#15
Camilla Signorini, Aristodemo Carpen, Luigi Coletto, Gigliola Borgonovo, Elisabetta Galanti, Jessica Capraro, Chiara Magni, Ambra Abate, Stuart K Johnson, Marcello Duranti, Alessio Scarafoni
Fermentation represents a valuable and cost-effective approach for food stabilisation and nutritional improvement. Tempeh is an example of soybean solid-state fermentation. In this work, we investigated the possibility of producing a tempeh analogue containing high amounts of vitamin B12 using seeds of three different species of the legume lupin, namely Lupinus albus, L. angustifolius and L. mutabilis, with Rhizopus oligosporus and Propionibacterium freudenreichii cofermentation. Synergic effects of Rhizopus and Propionibacterium in increasing vitamin B12 up to 1230 ng/g dw was observed...
October 18, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29040465/the-fut2-secretor-variant-p-trp154ter-influences-serum-vitamin-b12-concentration-via-holo-haptocorrin-but-not-holo-transcobalamin-and-is-associated-with-haptocorrin-glycosylation
#16
Aneliya Velkova, Jennifer E L Diaz, Faith Pangilinan, Anne M Molloy, James L Mills, Barry Shane, Erica Sanchez, Conal Cunningham, Helen McNulty, Cheryl D Cropp, Joan E Bailey-Wilson, Alexander F Wilson, Lawrence C Brody
Vitamin B12 deficiency is common in older individuals. Circulating vitamin B12 concentration can be used to diagnose deficiency but this test has substantial false positive and false negative rates. We conducted genome-wide association studies (GWAS) in which we resolved total serum vitamin B12 into the fractions bound to transcobalamin and haptocorrin: two carrier proteins with very different biological properties. We replicated reported associations between total circulating vitamin B12 concentrations and a common null variant in FUT2...
October 12, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29033987/dietary-practices-and-nutritional-profile-of-female-nurses-from-government-hospitals-in-delhi-india
#17
Shipra Gupta
BACKGROUND: Nursing is a demanding profession and nurses face a considerable degree of stress at work that can adversely influence their dietary practices and nutritional status. The current study was designed to conduct a preliminary investigation of the dietary practices and nutritional profile of nurses from government hospitals in Delhi. MATERIALS AND METHODS: A cross-sectional descriptive study was carried out among 80 female nurses aged between 25 and 39 years from government hospitals...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29032242/combination-of-vitamin-b12-active-forms-improved-fetal-growth-in-wistar-rats-through-up-regulation-of-placental-mir-16-and-mir-21-levels
#18
Tejas Shah, Sanjay Mishra, Amol More, Suhas Otiv, Kishori Apte, Kalpana Joshi
AIM: Epidemiological studies have indicated importance of folate and vitamin (B12) during pregnancy. Also available evidence on efficacy of B12 forms viz. Cyanocobalamin (Cbl), Methylcobalamin (MeCbl), Adenosylcobalamin (AdCbl) and Hydroxycobalamin (HCbl) in preventing or treating cobalamin deficiency is limited. The present study examines the effect of various forms of B12 in combination with folate during pregnancy and their effect on gestational outcomes. MAIN METHOD: In the present study, we examined the effect of various vitamin B12 forms in presence of recommended folate (RFol: 400μg/day) and high folate (HFol: 5mg/day) on gestational outcomes in female Wistar rats...
December 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/29023761/natural-vitamin-b12-and-fucose-supplementation-of-green-smoothies-with-edible-algae-and-related-quality-changes-during-their-shelf-life
#19
Noelia Castillejo, Ginés Benito Martínez Hernández, Valentina Goffi, Perla A Gómez, Encarna Aguayo, Francisco Artés, Francisco Artés Hernández
BACKGROUND: Some algae are an excellent source of vitamin B12, of special interest for vegetarian/vegan consumers, and of fucose to supplement fruit and vegetables beverages like smoothies. Nevertheless, the algae supplementation of smoothies may lead to possible quality changes during smoothie shelf life that needs to be studied. Therefore, the quality changes of fresh green smoothies supplemented (2.2%) with 9 edible algae (sea lettuce, kombu, wakame, thongweed, dulse, Irish moss, nori, spirulina and chlorella) were studied throughout 24 days at 5°C...
October 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29016304/hair-mercury-level-is-associated-with-anemia-and-micronutrient-status-in-children-living-near-artisanal-and-small-scale-gold-mining-in-the-peruvian-amazon
#20
Caren Weinhouse, Ernesto J Ortiz, Axel J Berky, Paige Bullins, John Hare-Grogg, Laura Rogers, Ana-Maria Morales, Heileen Hsu-Kim, William K Pan
Anemia has been widely studied in global health contexts because of severe nutritional deficiency, and more recently, inflammatory status, but chemical exposures are rarely considered. Until recently, "anemia" was used synonymously with "iron deficiency anemia (IDA)" in global health settings. However, only 50% of anemia cases worldwide are IDA. Environmental toxicology studies of anemia risk have generally focused on populations in developed countries, albeit with high exposure to environmental toxicants, such as lead or cadmium...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
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