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JOURNAL ARTICLE
Maxim Rubin-Blum, Yizhaq Makovsky, Eyal Rahav, Natalia Belkin, Gilad Antler, Guy Sisma-Ventura, Barak Herut
Discharge of gas-rich brines fuels productive chemosynthetic ecosystems in the deep sea. In these salty, methanic and sulfidic brines, microbial communities adapt to specific niches along the physicochemical gradients. However, the molecular mechanisms that underpin these adaptations are not fully known. Using metagenomics, we investigated the dense (∼106 cell ml-1 ) microbial communities that occupy small deep-sea brine pools found in the Southeastern Mediterranean Sea (1150 m water depth, ∼22 °C, ∼60 PSU salinity, sulfide, methane, ammonia reaching millimolar levels, and oxygen usually depleted), reaching high productivity rates of 685 μg C L-1 d-1 ex-situ...
April 14, 2024: Marine Environmental Research
#2
JOURNAL ARTICLE
Omar Al Jassem, Karim Kheir, Ali Ismail, Linda Abou-Abbas, Alaa Masri, Celine Haddad, Khalil Nasrallah
BACKGROUND: Vitamin B12 deficiency is responsible for a variety of complications, particularly neurological/neuropsychiatric complications, including depression, irritability, paresthesia and insomnia. Since vitamin B12 is found in animal-derived products, vegans/vegetarians are at a greater risk for developing vitamin B12 deficiency. AIMS: This study aims to investigate the occurrence of vitamin B12 deficiency among a sample of adult Lebanese population, with a particular emphasis on assessing the severity of its neurological/neuropsychiatric signs and symptoms, especially among vegans/vegetarians...
2024: PloS One
#3
JOURNAL ARTICLE
Wenliang He, Erin D Connolly, Guoyao Wu
As for other mammals, the digestive system of dogs (facultative carnivores) and cats (obligate carnivores) includes the mouth, teeth, tongue, pharynx, esophagus, stomach, small intestine, large intestine, and accessory digestive organs (salivary glands, pancreas, liver, and gallbladder). These carnivores have a relatively shorter digestive tract but longer canine teeth, a tighter digitation of molars, and a greater stomach volume than omnivorous mammals such as humans and pigs. Both dogs and cats have no detectable or a very low activity of salivary α-amylase but dogs, unlike cats, possess a relatively high activity of pancreatic α-amylase...
2024: Advances in Experimental Medicine and Biology
#4
JOURNAL ARTICLE
Reem Al-Sabah, Abdullah Al-Taiar, Ali H Ziyab, Saeed Akhtar, Majeda S Hammoud
BACKGROUND: Pregnant and postpartum women are at high risk of depression due to hormonal and biological changes. Antenatal depression is understudied compared to postpartum depression and its predictors remain highly controversial. AIM: To estimate the prevalence of depressive symptoms during pregnancy and investigate factors associated with this condition including vitamin D, folate and Vitamin B12 among participants in the Kuwait Birth Study. METHODS: Data collection occurred as part of the Kuwait Birth Cohort Study in which pregnant women were recruited in the second and third trimester during antenatal care visits...
April 15, 2024: Journal of Epidemiology and Global Health
#5
JOURNAL ARTICLE
Austin D Ready, Yessica A Nelson, Daniel F Torres Pomares, Alexander M Spokoyny
ConspectusIn this Account, we discuss our group's research over the past decade on a class of functionalized boron clusters with tunable chemical and physical properties, with an emphasis on accessing and controlling their redox behavior. These clusters can be thought of as three-dimensional aromatic systems that have distinct redox behavior and photophysical properties compared to their two-dimensional organic counterparts. Specifically, our lab has studied the highly tunable, multielectron redox behavior of B12 (OR)12 clusters and applied these molecules in various settings...
April 15, 2024: Accounts of Chemical Research
#6
JOURNAL ARTICLE
Madleen Nabil Al-Qusous, Wajdi Khalaf Jamil Al Madanat, Rasha Mohamed Hussein
BACKGROUND: Obesity is an abnormal fat accumulation that adversely affects human health. Studies reported several vitamin deficiencies in obese patients. The current study investigates the deficiencies of vitamins D, B6, and B12 among Jordanian adults with hyperlipidemia and demonstrates the association between serum vitamin levels and metabolic and lipid profile parameters. METHODS: Sixty male subjects were divided into 40 hyperlipidemic patients (age: 45.9 yr...
October 2023: Reports of Biochemistry & Molecular Biology
#7
JOURNAL ARTICLE
Sanjiv Agarwal, Victor L Fulgoni
Beef is an important source of high-quality protein and several micronutrients, including iron, zinc, and B-vitamins. The objective was to assess the association of beef intake with nutrient intake and adequacy among pregnant and lactating women using 24-h dietary recall data. Usual intakes from foods were determined with the National Cancer Institute (NCI) method and % population below Estimated Average Requirement (EAR) or above Adequate Intake (AI) were estimated. A high proportion of pregnant and lactating women had inadequate intakes for vitamin D (94%), vitamin E (82%), vitamin C (52%), and vitamin A (50%), magnesium (35%), folate (31%), zinc (25%), and vitamin B6 (22%); only 4% and 35% met AI for choline and potassium, respectively...
March 28, 2024: Nutrients
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JOURNAL ARTICLE
Suzanne A Alvernaz, Elizabeth S Wenzel, Unnathi Nagelli, Lacey B Pezley, Bazil LaBomascus, Jack A Gilbert, Pauline M Maki, Lisa Tussing-Humphreys, Beatriz Peñalver Bernabé
Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, pre-eclampsia, preterm birth, and mood disorders. However, the effects of high-inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored...
March 24, 2024: Nutrients
#9
JOURNAL ARTICLE
Aanchal Sharma, Demetra Pappas, Joseph Gonzalez-Heydrich, Nancy R Sullivan, Sarah S Nyp
Nick is a 5-year-old boy who began displaying self-stimulating behaviors and decreased social interactions shortly before turning 3 years. At the age of 3.5 years, he was diagnosed with autism spectrum disorder by a local developmental-behavioral pediatrician. His parents recall that the physician described Nick to be "high functioning" and encouraged them to expect that he would attend college and live independently as an adult. Upon receiving the diagnosis, intervention was initiated using an applied behavioral analysis (ABA) approach...
April 11, 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
#10
JOURNAL ARTICLE
Phirawat Phromprathum, Sittiporn Srinualnad, Sunai Leewansangtong, Tawatchai Taweemonkongsap, Kittipong Phinthusophon, Siros Jitpraphai, Patkawat Ramart, Varat Woranisarakul, Chalairat Suk-Ouichai, Thawatchai Mankongsrisuk, Thitipat Hansomwong, Kantima Jongjitaree, Ekkarin Chotikawanich
INTRODUCTION: Disposable (single-use) flexible ureteroscopes are alternatives to reusable ureteroscopes. With their superior surgical efficacy and safety in the presence of upper urinary calculi, disposable ureteroscopes aim to overcome the main limitations of conventional reusable ureteroscopes. However, studies on the performance of the most recently developed models of single-use flexible ureteroscopes are scarce. This study aimed to compare the in vitro performance of several recently introduced, single-use, flexible ureteroscopes...
April 10, 2024: Urologia Internationalis
#11
JOURNAL ARTICLE
Johannes Lübke, Alicia Schmid, Deborah Christen, Hanneke N G Oude Elberink, Lambert F R Span, Marek Niedoszytko, Aleksandra Górska, Magdalena Lange, Karoline V Gleixner, Emir Hadzijusufovic, Alex Stefan, Irena Angelova-Fischer, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Bonadonna, Khalid Shoumariyeh, Nikolas von Bubnoff, Sabine Müller, Cecelia Perkins, Chiara Elena, Luca Malcovati, Hans G Hagglund, Mattias Mattsson, Roberta Parente, Judit Varkonyi, Anna Belloni Fortina, Francesca Caroppo, Knut Brockow, Alexander Zink, Christine Breynaert, Toon Ieven, Akif Selim Yavuz, Michael Doubek, Vito Sabato, Tanja Schug, Karin Hartmann, Massimo Triggiani, Jason Gotlib, Olivier Hermine, Michel Arock, Hanneke C Kluin-Nelemans, Jens Peter Panse, Wolfgang R Sperr, Peter Valent, Andreas Reiter, Juliana Schwaab
Certain laboratory abnormalities correlate with subvariants of systemic mastocytosis (SM) and are often prognostically relevant. To assess the diagnostic and prognostic value of individual serum chemistry parameters in SM, 2607 patients enrolled within the European Competence Network on Mastocytosis (ECNM) and 575 patients enrolled within the German Registry on Eosinophils and Mast Cells (GREM) were analyzed. For screening and diagnosis of SM, tryptase was identified as the most specific serum parameter. For differentiation between indolent and advanced SM (AdvSM), the following serum parameters were most relevant: tryptase, alkaline phosphatase (AP), ß2-microglobulin, lactate dehydrogenase (LDH), albumin, vitamin B12, and C-reactive protein (P<0...
April 9, 2024: Blood Advances
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JOURNAL ARTICLE
Giovana Regina Weber Hoss, Fernanda Sperb-Ludwig, Tássia Tonon, Soraia Poloni, Sidney Behringer, Henk J Blom, François Maillot, Ida Vanessa Doederlein Schwartz
Hyperhomocysteinemia and vitamin B12 deficiency have been reported in patients with phenylketonuria. In this study, total homocysteine (tHcy) and methylmalonic acid (MMA) levels were analyzed in samples from 25 phenylketonuria (PKU) patients. Comparisons were made between pre- and post-treatment values (n= 3); on treatment values, between periods with high and normal/low phenylalanine (Phe) levels (n= 20); and in women before, during and after pregnancy (n= 3). THcy levels decreased after treating PKU with metabolic formula (p=0...
2024: Genetics and Molecular Biology
#13
JOURNAL ARTICLE
John J Maurer, Ying Cheng, Adriana Pedroso, Kasey K Thompson, Shamima Akter, Tiffany Kwan, Gota Morota, Sydney Kinstler, Steffen Porwollik, Michael McClelland, Jorge C Escalante-Semerena, Margie D Lee
Baby chicks administered a fecal transplant from adult chickens are resistant to Salmonella colonization by competitive exclusion. A two-pronged approach was used to investigate the mechanism of this process. First, Salmonella response to an exclusive ( Salmonella competitive exclusion product, Aviguard® ) or permissive microbial community (chicken cecal contents from colonized birds containing 7.85 Log10 Salmonella genomes/gram) was assessed ex vivo using a S. typhimurium reporter strain with fluorescent YFP and CFP gene fusions to rrn and hilA operon, respectively...
2024: Frontiers in Microbiology
#14
JOURNAL ARTICLE
Qian Rang Zhu, E Kok Dieuwertje, Hailu Tesfaye Bekele, Koen Manusama, Jing Xian Zhang, Wei Xie, Wen Qi Zong, Hui Zuo, Jian Zhang, Ellen Kampman, Yue Dai
OBJECTIVE: This study aimed to evaluate the associations of serum folate and/or vitamin B 12 concentrations with obesity among Chinese children and adolescents. METHODS: A cross-sectional study was conducted including 3,079 Chinese children and adolescents, aged 6 to 17 years, from Jiangsu, China. Anthropometric indices, such as, children's body mass index (BMI), BMI z-scores, waist circumference, and waist-to-height ratio were utilized. Multivariable linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B 12 levels with anthropometric indices and odds of obesity...
March 20, 2024: Biomedical and Environmental Sciences: BES
#15
JOURNAL ARTICLE
Seyed Mohammad Taghi Gharibzahedi, Zeynep Altintas
A combined approach of microbial transglutaminase (MTGase) crosslinking and high-intensity ultrasound (HIU) was implemented to improve the physicochemical, rheological, structural, and thermal properties, as well as the targeted release of vitamin B12 of lesser mealworm protein isolate (LMPI)-based gels. Prolonging HIU to 60 min significantly reduced LMPIs' size, polydispersity, zeta-potential, and fluorescence intensity while increasing surface hydrophobicity, free amino (FAGs), and sulfhydryl (FSGs) groups...
March 21, 2024: Food Chemistry
#16
JOURNAL ARTICLE
Franziska Müller, Jasmin Jansen, Fabian Offensperger, Daniela Eichbichler, Florian Stengel, Martin Scheffner
Genetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in the maternal allele resulting in the expression of full-length E6AP variants that frequently display compromised ligase activity. In a high-throughput screen, we identified cyanocobalamin, a vitamin B12-derivative, and several alloxazine derivatives as activators of the AS-linked E6AP-F583S variant...
April 4, 2024: Chembiochem: a European Journal of Chemical Biology
#17
JOURNAL ARTICLE
Bostjan Jakše, Barbara Gilić, Marko Đurović, Dorica Šajber
COVID-19 infection and its consequences (long-term COVID-19 syndrome) have implications for weight loss, body composition, and diet quality. In the context of the "PostCovSwim" project, which is part of a broader international study, the impact of an eight-week swimming program on post-COVID-19 patients' nutritional status (i.e., body composition and dietary intake) was evaluated. Body composition and dietary intake were assessed by medically approved and calibrated bioelectrical impedance (Tanita 780 S MA) and food frequency questionnaires...
2024: Journal of Nutrition and Metabolism
#18
JOURNAL ARTICLE
Ursula M Leonard, Clarissa L Leydon, Elena Arranz, Mairead E Kiely
BACKGROUND: A global move toward consumption of diets from sustainable sources is required to protect planetary health. As this dietary transition will result in greater reliance on plant-based protein sources, the impact on micronutrient (MN) intakes and status is unknown. OBJECTIVE: Evaluate the evidence of effects on intakes and status of selected MNs resulting from changes in dietary intakes to reduce environmental impact. Selected MNs of public health concern were vitamins A, D, and B12, folate, calcium, iron, iodine, and zinc...
April 2024: American Journal of Clinical Nutrition
#19
REVIEW
Sandeep Chaudhary, Amitabh Kulkarni
PURPOSE OF REVIEW: This review provides the most recent update of metformin, a biguanide oral antihyperglycemic drug used as a first-line treatment in type 2 diabetes mellitus. RECENT FINDINGS: Metformin continues to dominate in the world of antidiabetics, and its use will continue to rise because of its high efficiency and easy availability. Apart from type 2 diabetes, research is exploring its potential in other conditions such as cancer, memory loss, bone disorders, immunological diseases, and aging...
April 3, 2024: Current Diabetes Reports
#20
JOURNAL ARTICLE
Ali Erkan Aşcı, Gürdal Orhan, Bensu Karahalil
BACKGROUND AND AIMS: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown cause. Alterations in one-carbon metabolism have impact in the pathophysiology by genetic susceptibility to MS and increased the risk of MS. The aim of this study was to investigate the contribution of the gene polymorphism on Methylenetetrahydrofolate Reductase ( MTHFR ), Methionine Synthase Reductase ( MTRR ), Methionine Synthase (MTR ) enzymes and of the essential factors (homocysteine, Hcy ; cysteine, Cys ; and vitamin B12, VitB12 ) in folate metabolism...
April 2, 2024: Neurological Research
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