keyword
https://read.qxmd.com/read/38543556/genomic-characterization-of-multidrug-resistant-pathogenic-enteric-bacteria-from-healthy-children-in-osun-state-nigeria
#1
JOURNAL ARTICLE
Jessica N Uwanibe, Idowu B Olawoye, Christian T Happi, Onikepe A Folarin
Antimicrobial resistance (AMR) is responsible for the spread and persistence of bacterial infections. Surveillance of AMR in healthy individuals is usually not considered, though these individuals serve as reservoirs for continuous disease transmission. Therefore, it is essential to conduct epidemiological surveillance of AMR in healthy individuals to fully understand the dynamics of AMR transmission in Nigeria. Thirteen multidrug-resistant Citrobacter spp., Enterobacter spp., Klebsiella pneumoniae , and Escherichia coli isolated from stool samples of healthy children were subjected to whole genome sequencing (WGS) using Illumina and Oxford nanopore sequencing platforms...
March 1, 2024: Microorganisms
https://read.qxmd.com/read/38539395/neurofilament-light-chain-concentration-in-cerebrospinal-fluid-in-children-with-acute-nontraumatic-neurological-disorders
#2
JOURNAL ARTICLE
Tobias Geis, Svena Gutzeit, Sigrid Disse, Jens Kuhle, Sotiris Fouzas, Sven Wellmann
(1) Introduction: This pilot study aimed to analyze neurofilament light chain levels in cerebrospinal fluid (cNfL) in a cohort of children with different acute nontraumatic neurological conditions. (2) Methods: This prospective observational cohort study consisted of 35 children aged 3 months to 17 years and was performed from November 2017 to December 2019. Patients' clinical data were reviewed, and patients were assigned to the following groups: n = 10 (28.6%) meningitis, 5 (14.3%) Bell's palsy, 7 (20.0%) febrile non-CNS infection, 3 (8...
March 19, 2024: Children
https://read.qxmd.com/read/38535887/multiple-drug-resistant-shiga-toxin-producing-e-coli-in-raw-milk-of-dairy-bovine
#3
JOURNAL ARTICLE
Safir Ullah, Saeed Ul Hassan Khan, Muhammad Jamil Khan, Baharullah Khattak, Fozia Fozia, Ijaz Ahmad, Mohammad Ahmad Wadaan, Muhammad Farooq Khan, Almohannad Baabbad, Sagar M Goyal
INTRODUCTION: Raw milk may contain pathogenic microorganisms harmful to humans, e.g., multidrug-resistant Escherichia coli non-O157:H7, which can cause severe colitis, hemolytic uremia, and meningitis in children. No studies are available on the prevalence of Shiga toxin-producing E. coli (STEC O157:H7) in sick or healthy dairy animals in the Khyber Pakhtunkhwa Province of Pakistan. AIM: This study aimed to isolate, characterize, and detect antibiotic resistance in STEC non-O157:H7 from unpasteurized milk of dairy bovines in this province...
March 19, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535091/enterococcal-central-nervous-system-infections-in-children-a-22-years-experience-in-a-tertiary-center-and-review-of-the-literature
#4
JOURNAL ARTICLE
Aviad Schnapp, Sergei Elber-Dorozko, Violeta Temper, Oren Gordon, Dina Averbuch
BACKGROUND: Enterococcal meningitis in children is rare, and its clinical presentation, laboratory characteristics and outcomes are not well defined. METHODS: We conducted a retrospective analysis of Enterococcal meningitis cases during 2002-2023 at our tertiary center. RESULTS: We identified 10 cases in children aged 2 weeks to 15 years (median age: 8 months). Seven children were males and 9 had comorbidities, including a ventriculoperitoneal shunt in 5 children...
March 26, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38533114/whole-genome-sequencing-data-of-streptococcus-pneumoniae-isolated-from-indonesian-population
#5
JOURNAL ARTICLE
Miftahuddin Majid Khoeri, Yustinus Maladan, Korrie Salsabila, Lindawati Alimsardjono, Naritha Vermasari, Iva Puspitasari, Rina Yunita, Wisnu Tafroji, Rosantia Sarassari, Ratna Fathma Sari, Sarah Azhari Balqis, Ghina Athyah Wahid, Diana Shinta Purwanto, Kuntjoro Harimurti, Amin Soebandrio, Dodi Safari
Streptococcus pneumoniae is the leading cause of bacterial pneumonia, bacteremia, and meningitis. Indonesia introduced the pneumococcal conjugate vaccine (PCV) nationwide in 2022. In this study, we present whole genome sequence (WGS) data of 94 S. pneumoniae isolates that were obtained from hospitalized patients, healthy children, and adult groups from different regions prior to PCV program in Indonesia. DNA sequences of S. pneumoniae were obtained using the TruSeq Nano DNA kit (Illumina NovaSeq6000 Platform)...
April 2024: Data in Brief
https://read.qxmd.com/read/38517733/the-important-lessons-lurking-in-the-history-of-meningococcal-epidemiology
#6
REVIEW
Ray Borrow, Jamie Findlow
INTRODUCTION: The epidemiology of invasive meningococcal disease (IMD), a rare but potentially fatal illness, is typically described as unpredictable and subject to sporadic outbreaks. AREAS COVERED: Meningococcal epidemiology and vaccine use during the last ~200 years are examined within the context of meningococcal characterization and classification to guide future IMD prevention efforts. EXPERT OPINION: Historical and contemporary data highlight the dynamic nature of meningococcal epidemiology, with continued emergence of hyperinvasive clones and affected regions...
March 22, 2024: Expert Review of Vaccines
https://read.qxmd.com/read/38515374/meningococcal-meningitis-in-spain-in-the-horizon-2030-a-position-paper
#7
REVIEW
F Moraga-Llop, E Andradas, L C Blesa-Baviera, R Cantón, J González Del Castillo, F Martinón-Torres, E Moya, A Trilla, J Vazquez, R J Villena, J Ruiz-Galiana, P De Lucas Ramos, A García-Botella, A García-Lledó, T Hernández-Sampelayo, J Gómez-Pavón, M C Martín-Delgado, F J Martín Sánchez, M Martínez-Sellés, J M Molero García, S Moreno Guillén, F J Rodríguez-Artalejo, E Bouza
Meningococcal meningitis (MM) and invasive meningococcal disease remain a major public health problem that generates enormous public alarm. It is caused by Neisseria meningitidis, a Gram-negative diplococcus with an enormous capacity for acute and rapidly progressive disease, both episodic and epidemic in nature, with early diagnosis and treatment playing a major role. It occurs at any age, but is most common in children under 5 years of age followed by adolescents. Although most cases occur in healthy people, the incidence is higher in certain risk groups...
March 22, 2024: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://read.qxmd.com/read/38511552/seizures-focal-neurological-signs-and-pneumococcal-aetiology-associate-with-impaired-consciousness-in-childhood-bacterial-meningitis
#8
JOURNAL ARTICLE
Ester Valtiala, Irmeli Roine, Manuel Leite Cruzeiro, Heikki Peltola, Tuula Pelkonen
AIM: A low Glasgow Coma Scale Score (GCS) on admission is a known predictor of poor outcome from childhood bacterial meningitis. In turn, the factors associated with the admission GCS are less known. Our aim was to identify them, both for clinical alerts of reserved prognosis and to find potential targets for intervention. METHODS: This study is a secondary analysis of data collected prospectively in Angola and in Latin America between 1996 and 2007. Children with bacterial meningitis were examined on hospital admission and their GCS was assessed using the age-adjusted scale...
March 21, 2024: Acta Paediatrica
https://read.qxmd.com/read/38510876/parental-knowledge-toward-meningococcal-disease-and-vaccination-in-makkah-region-saudi-arabia-a-cross-sectional-study
#9
JOURNAL ARTICLE
Ibrahim S Alibrahim, Abdulrahman I Khoj, Abdullah S Alibrahim, Khalid H Alnafei, Abrar A Alghamdi, Turki T Alessa, Abdulrahman M Alsuwayhiri, Naif M Almeqaty
Background Invasive meningococcal disease (IMD) is a bacterial infection caused by Neisseria meningitidis, which primarily affects the meninges, with a high incidence in young children. The most effective technique for preventing IMD is vaccination, which has been available for over 40 years through meningococcal polysaccharide capsule-containing vaccines. This study aims to assess the parental knowledge of meningococcal disease and vaccination in the Makkah region of Saudi Arabia. Methodology A cross-sectional study was conducted between September and December 2023 among 597 parents in the Makkah region using a validated online survey...
February 2024: Curēus
https://read.qxmd.com/read/38506454/current-clinical-evidence-is-insufficient-to-support-hmme-pdt-as-the-first-choice-of-treatment-for-young-children-with-port-wine-birthmarks
#10
REVIEW
Chao Gao, Vi Nguyen, Marcelo L Hochman, Lin Gao, Elliott H Chen, Harold I Friedman, John Stuart Nelson, Wenbin Tan
BACKGROUND: Port wine birthmark (PWB) is a congenital vascular malformation of the skin. Pulsed dye laser (PDL) is the "gold standard" for the treatment of PWB globally. Hematoporphyrin monomethyl ether (HMME or hemoporfin)-mediated photodynamic therapy (HMME-PDT) has emerged as the first choice for PWB treatment, particularly for young children, in many major hospitals in China during the past several decades. AIM: To evaluate whether HMME-PDT is superior to PDL by comparing the clinical efficacies of both modalities...
March 20, 2024: Lasers in Surgery and Medicine
https://read.qxmd.com/read/38504350/fulminant-coronavirus-disease-2019-meningitis-in-iranian-infants-a%C3%A2-case-series
#11
JOURNAL ARTICLE
Shahla Afsharpayman, Sedigheh Madani, Susan Amirsalari, Nooradin Momeni, Mohammad Torkaman, Fatemeh Beiraghdar, Zohreh Kavehmanesh, Zahra Hosseininezhad
BACKGROUND: Pediatric coronavirus disease 2019 infection usually presents with respiratory and gastrointestinal symptoms. In this report we present fulminant meningitis as the main presentation of coronavirus disease 2019 without major signs and symptoms of other organs' involvement in 3 infants. CASES: The first case was a 4 months Iranian male infant with fulminant meningitis as the main presentation of coronavirus disease 2019 without other organ involvement...
March 20, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38504305/determine-the-factors-affecting-the-time-to-recovery-of-children-with-bacterial-meningitis-at-jigjiga-university-referral-hospital-in-the-somali-regional-state-of-ethiopia-using-the-parametric-shared-frailty-and-aft-models
#12
JOURNAL ARTICLE
Daud Hussein Adawe, Dagne Tesfaye Mengistie
BACKGROUND: Neisseria meningitides, Streptococcus pneumonia, and hemophilic influenza type B are frequently linked to bacterial meningitis (BM) in children. It's an infectious sickness that kills and severely mobilizes children. For a variety of reasons, bacterial meningitis remains a global public health concern; most cases and deaths are found in Sub-Saharan Africa, particularly in Ethiopia. Even though vaccination has made BM more preventable, children worldwide are still severely harmed by this serious illness...
March 19, 2024: BMC Research Notes
https://read.qxmd.com/read/38498171/duraplasty-with-autologous-cervical-fascia-in-pediatric-posterior-fossa-tumor-surgery-a-single-center-experience-with-214-cases
#13
JOURNAL ARTICLE
Neslihan Nisa Gecici, Muhammet Enes Gurses, Ahmet Ilkay Isikay, Burcak Bilginer, Sahin Hanalioglu
PURPOSE: Posterior fossa surgeries for pediatric tumors pose challenges in achieving optimal dural repair and duraplasty is usually required. Autografts, allografts, xenografts, and synthetic substitutes can be used for duraplasty. Autologous cervical fascia can be a safe and reliable graft option for duraplasty after posterior fossa surgeries. This study aims to investigate the outcomes of duraplasty with autologous cervical fascial graft in children after posterior fossa surgery for pediatric brain tumors...
March 18, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38494838/endoscopic-transnasal-management-of-meningoceles-and-encephaloceles-in-children-a-systematic-review
#14
REVIEW
Alyssa Y Li, Karolina Gaebe, Jennifer L Quon, Allan Vescan, Adrian L James, Nikolaus E Wolter
OBJECTIVE: To review surgical techniques used in the endoscopic transnasal repair of pediatric basal meningoencephaloceles and compare perioperative outcomes in children <2 and ≥2 years old. DATA SOURCES: MEDLINE, EMBASE, and CENTRAL. REVIEW METHODS: Data sources were searched from inception to August 22, 2022, using search terms relevant to endoscopic transnasal meningoencephalocele repair in children. Reviews and Meta-analyses were excluded...
March 17, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38493326/clinical-characteristics-etiology-and-outcomes-of-hypothermia-in-well-appearing-children-referred-to-the-emergency-department
#15
JOURNAL ARTICLE
Lea Ohana Sarna, Dina Qaraen Saloni, Mevaseret Avital, Naama Pines, Itai Gross, Giora Wieser, Saar Hashvya
BACKGROUND: Hypothermia, as a sign of serious bacterial infection (SBI) in children and infants older than 90 days is poorly characterized, especially in the post-pneumococcal vaccine era. OBJECTIVES: To assess the prevalence of SBI in children and infants presenting to the pediatric emergency department (PED) with reported or documented hypothermia. METHODS: Retrospective data analysis was conducted of all well-appearing children aged 0-16 years who presented with a diagnosis of hypothermia at two tertiary PEDs from 2010 to 2019...
March 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38492637/reflecting-on-the-1998-enterovirus-outbreak-a-25-year-retrospective-and-learned-lessons
#16
REVIEW
Peng-Nien Huang, Shao-Hsuan Hsia, Kuan-Ying Arthur Huang, Chih-Jung Chen, En-Tzu Wang, Shin-Ru Shih, Tzou-Yien Lin
Enterovirus A71 (EV-A71) infections pose a significant public health concern in the Asia-Pacific region. EV-A71 is primarily responsible for causing hand, foot, and mouth disease (HFMD) in children. However, this virus can also lead to severe and potentially fatal neurological consequences in affected individuals. This review aims to provide a comprehensive understanding of the molecular virology, epidemiology, and recombination events associated with EV-A71. The literature extensively covers the clinical manifestations and neurological symptoms that accompany EV-A71 infections...
March 14, 2024: Biomedical Journal
https://read.qxmd.com/read/38492030/clinical-course-and-peculiarities-of-parechovirus-and-enterovirus-central-nervous-system-infections-in-newborns-a-single-center-experience
#17
JOURNAL ARTICLE
Giacomo Brisca, Tommaso Bellini, Mattia Pasquinucci, Marcello Mariani, Marta Romanengo, Isabella Buffoni, Domenico Tortora, Alessandro Parodi, Elena Fueri, Alessio Mesini, Jessica Tibaldi, Emanuela Piccotti, Luca Antonio Ramenghi, Andrea Moscatelli
Parechovirus (HpEV) and Enterovirus (EV) infections in children mostly have a mild course but are particularly fearsome in newborns in whom they may cause aseptic meningitis, encephalitis, and myocarditis. Our study aimed to describe the clinical presentations and peculiarities of CNS infection by HpEV and EV in neonates. This is a single-center retrospective study at Istituto Gaslini, Genoa, Italy. Infants aged ≤ 30 days with a CSF RTq-PCR positive for EV or HpEV from January 1, 2022, to December 1, 2023, were enrolled...
March 16, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38488459/rare-cases-of-pseudomonas-aeruginosa-meningitis-in-children-10-year-experience-in-a-single-center
#18
JOURNAL ARTICLE
Lijun Liu, Lvchang Zhu, Chanchan Hu, Shuzhen Zhu, Sheng Ye
OBJECTIVE: The primary objective was to elucidate the epidemiologic characteristics, risk determinants, and clinical outcomes associated with Pseudomonas aeruginosa -induced meningitis. METHODS: All cases of meningitis caused by Pseudomonas aeruginosa that were treated at the hospital between 2012 and 2022 were retrospectively analyzed and detailed. RESULTS: During a 10-year period, only 10 patients satisfied the inclusion criteria. Three patients had previously undergone neurosurgical procedures and 4 patients had leukemia...
March 15, 2024: Journal of Child Neurology
https://read.qxmd.com/read/38482535/outcomes-symptomatology-and-mortality-of-children-presenting-with-bacterial-meningitis-at-allied-hospitals-of-rawalpindi-medical-university-pakistan-a-cross-sectional-study
#19
JOURNAL ARTICLE
Muhammad Zarak Khan, Aiman Waheed, Faizan Fazal, Shahrukh Ahmad Khan, Ehsan Ahmad, Sanan Rasheed, Talha Ijaz, Areesha Abid, Saima Ambreen, Bilal Haider Malik
Introduction Bacterial meningitis (BM) is a neurologic emergency mainly affecting children under the age of two. Clinical symptoms are rarely evident in children, thus making a diagnosis is a challenge. Antibiotic therapy should be started timely to ensure the avoidance of significant morbidity and mortality. This study aims to assess the outcomes, mortality, and symptomatology of children presenting with BM in allied hospitals of Rawalpindi Medical University, Pakistan. Methods It is a cross-sectional study employing a sample size of 201, conducted at the Allied Hospitals of Rawalpindi Medical University, Pakistan from a period of January 2023 to August 2023...
March 2024: Curēus
https://read.qxmd.com/read/38482147/coverage-gaps-in-empiric-antibiotic-regimens-used-to-treat-serious-bacterial-infections-in-neonates-and-children-in-southeast-asia-and-the-pacific
#20
JOURNAL ARTICLE
Phoebe C M Williams, Mark Jones, Thomas L Snelling, Robert Duguid, Nerida Moore, Benjamin Dickson, Yue Wu, Jessica Saunders, Priyali Wijeratne, Anousone Douangnouvong, Elizabeth A Ashley, Paul Turner
BACKGROUND: High levels of antimicrobial resistance (AMR) are propagating deaths due to neonatal and paediatric infections globally. This is of particular concern in Southeast Asia and the Pacific, where healthcare resources are constrained and access to newer agents to treat multidrug-resistant pathogens is limited. METHODS: To assess the coverage provided by commonly prescribed empiric antibiotic regimens for children in low- and middle-income countries in Southeast Asia and the Pacific, we built a weighted incidence syndromic combination antibiogram (WISCA), parameterised using data obtained from a systematic review of published literature incorporating WHO-defined SEARO and WPRO regions in Ovid MEDLINE, EMBASE, Global Health and PubMed...
March 2024: Lancet Reg Health Southeast Asia
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