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JOURNAL ARTICLE
Martin Clodi, Heidemarie Abrahamian, Helmut Brath, Guntram Schernthaner, Johann Brix, Bernhard Ludvik, Heinz Drexel, Christoph H Saely, Peter Fasching, Gersina Rega-Kaun, Bernhard Föger, Claudia Francesconi, Elke Fröhlich-Reiterer, Alexandra Kautzky-Willer, Jürgen Harreiter, Anton Luger, Michael Resl, Michaela Riedl, Yvonne Winhofer, Sabine E Hofer, Friedrich Hoppichler, Joakim Huber, Susanne Kaser, Claudia Ress, Monika Lechleitner, Felix Aberer, Julia K Mader, Harald Sourij, Hermann Toplak, Bernhard Paulweber, Lars Stechemesser, Thomas Pieber, Rudolf Prager, Harald Stingl, Thomas Stulnig, Birgit Rami-Merhar, Heinz Drexel, Michael Roden, Christian Schelkshorn, Thomas C Wascher, Raimund Weitgasser, Sandra Zlamal-Fortunat
Hyperglycemia significantly contributes to complications in patients with diabetes mellitus. While lifestyle interventions remain cornerstones of disease prevention and treatment, most patients with type 2 diabetes will eventually require pharmacotherapy for glycemic control. The definition of individual targets regarding optimal therapeutic efficacy and safety as well as cardiovascular effects is of great importance. In this guideline we present the most current evidence-based best clinical practice data for healthcare professionals...
January 2023: Wiener Klinische Wochenschrift
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JOURNAL ARTICLE
Susanne Kaser, Sabine E Hofer, Lili Kazemi-Shirazi, Andreas Festa, Yvonne Winhofer, Harald Sourij, Helmut Brath, Michaela Riedl, Michael Resl, Martin Clodi, Thomas Stulnig, Claudia Ress, Anton Luger
The heterogenous category "specific types of diabetes due to other causes" encompasses disturbances in glucose metabolism due to other endocrine disorders such as acromegaly or hypercortisolism, drug-induced diabetes (e.g. antipsychotic medications, glucocorticoids, immunosuppressive agents, highly active antiretroviral therapy (HAART), checkpoint inhibitors), genetic forms of diabetes (e.g. Maturity Onset Diabetes of the Young (MODY), neonatal diabetes, Down‑, Klinefelter- and Turner Syndrome), pancreatogenic diabetes (e...
January 2023: Wiener Klinische Wochenschrift
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JOURNAL ARTICLE
Roland Feldbauer, Matthias Wolfgang Heinzl, Carmen Klammer, Michael Resl, Johannes Pohlhammer, Klemens Rosenberger, Verena Almesberger, Florian Obendorf, Lukas Schinagl, Thomas Wagner, Margot Egger, Benjamin Dieplinger, Martin Clodi
HYPOTHESIS: Glycaemic variability (GV) refers to fluctuations in the blood glucose level and may contribute to complications in patients suffering from Diabetes. Several studies show negative effects of GV on the cardiovascular system, however there is still a lack of conclusive evidence. Using an explorative cardiovascular panel, it is possible to simultaneously measure the effects on proteins relevant for cardiovascular processes. The aim of this study was to investigate the effects of rapid glucose excursions on cardiovascular and metabolic parameters in healthy individuals...
2022: PloS One
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JOURNAL ARTICLE
Matthias Wolfgang Heinzl, Lisa Kolenchery, Michael Resl, Carmen Klammer, Anne Black, Florian Obendorf, Lukas Schinagl, Roland Feldbauer, Johannes Pohlhammer, Thomas Wagner, Thomas Berger, Benjamin Dieplinger, Martin Clodi
BACKGROUND: Although vaccination against COVID-19 is highly effective, breakthrough infections occur, often leading to severe courses and death. The extent of protection provided by individual antibody levels in breakthrough infections is still unknown and cut-off levels have yet to be determined. METHODS: In 80 consecutive fully vaccinated patients hospitalized between August and December 2021 with COVID-19 breakthrough infection (Delta variant), anti-CoV2S antibody levels were analyzed for the endpoint of death...
November 24, 2022: International Journal of Environmental Research and Public Health
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JOURNAL ARTICLE
Michael Poppe, Ingrid A M Magnet, Christian Clodi, Matthias Mueller, Florian Ettl, David Neumayer, Heidrun Losert, Andrea Zeiner-Schatzl, Christoph Testori, Martin Roeggla, Christoph Schriefl
AIMS: Transoesophageal echocardiography (TOE) has increasingly been described as a possible complementary and point-of-care approach for patients with cardiac arrest (CA). It provides information about potentially reversible causes and prognosis and allows monitoring of resuscitation efforts without affecting ongoing chest compressions. The aim of this study was to assess the feasibility of TOE performed by emergency physicians (EPs) during CA in an emergency department (ED). METHODS AND RESULTS: This prospective study was performed at the Department of Emergency Medicine at the Medical University of Vienna from February 2020 to February 2021...
February 9, 2023: European Heart Journal. Acute Cardiovascular Care
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JOURNAL ARTICLE
Johannes Pohlhammer, Matthias Wolfgang Heinzl, Carmen Klammer, Roland Feldbauer, Klemens Rosenberger, Michael Resl, Thomas Wagner, Florian Obendorf, Margot Egger-Salmhofer, Benjamin Dieplinger, Martin Clodi
Fibroblast growth factor 21 (FGF21) affects the regulation of metabolism. Additionally, anti-inflammatory properties are attributed to FGF21, and studies in animals and humans show conflicting results. This study aimed to investigate how FGF21 is affected by glucose and lipopolysaccharide (LPS) in humans. Therefore, FGF21 was measured eight times at different time points within 48 h in this prospective cross-over trial after glucose and LPS on two different study days. The study included ten healthy, non-smoking male subjects aged 18-40...
November 22, 2022: Journal of Cellular and Molecular Medicine
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RANDOMIZED CONTROLLED TRIAL
Rohit Aggarwal, Christina Charles-Schoeman, Joachim Schessl, Zsuzsanna Bata-Csörgő, Mazen M Dimachkie, Zoltan Griger, Sergey Moiseev, Chester Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi, Olga Bugrova, Katalin Dankó, Floranne Ernste, Namita A Goyal, Marvin Heuer, Marie Hudson, Yessar M Hussain, Chafic Karam, Nina Magnolo, Ronald Nelson, Nataliia Pozur, Liudmyla Prystupa, Miklós Sárdy, Guillermo Valenzuela, Anneke J van der Kooi, Tuan Vu, Margitta Worm, Todd Levine
BACKGROUND: Intravenous immune globulin (IVIG) for the treatment of dermatomyositis has not been extensively evaluated. METHODS: We conducted a randomized, placebo-controlled trial involving patients with active dermatomyositis. The patients were assigned in a 1:1 ratio to receive IVIG at a dose of 2.0 g per kilogram of body weight or placebo every 4 weeks for 16 weeks. The patients who received placebo and those without confirmed clinical deterioration while receiving IVIG could enter an open-label extension phase for another 24 weeks...
October 6, 2022: New England Journal of Medicine
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JOURNAL ARTICLE
Matthias Mueller, Emmely Jankow, Juergen Grafeneder, Christian Schoergenhofer, Michael Poppe, Christoph Schriefl, Christian Clodi, Moritz Koch, Florian Ettl, Michael Holzer, Heidrun Losert
INTRODUCTION: In former studies, the arterio-alveolar carbon dioxide gradient (ΔCO2 ) predicted in-hospital mortality after initially survived cardiac arrest. As early outcome predictors are urgently needed, we evaluated ΔCO2 as predictor for good neurological outcome in our cohort. METHODS: We retrospectively analyzed all patients ≥18 years of age after non-traumatic in- and out of hospital cardiac arrest in the year 2018 from our resuscitation database...
November 2022: American Journal of Emergency Medicine
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Sebastian Schnaubelt, Felix Eibensteiner, Marieke Merrelaar, Daniel Tihanyi, Robert Strassl, Christian Clodi, Hans Domanovits, Heidrun Losert, Michael Holzer
Respiratory syncytial virus (RSV) is a well-known pathogen in paediatric patients. However, it also causes substantial morbidity and mortality in adults, posing a major healthcare problem. We present a patient with chronic pulmonary conditions and an acute RSV infection, thus leading to cardiac arrest (CA). We speculate that RSV as the causative agent for CA should be considered in post-resuscitation care. From a wider public health perspective, immuno-naivety for RSV caused by the coronavirus disease 2019 pandemic may induce a severe rise in cases, morbidity, and mortality in the future...
August 18, 2022: Medicina
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JOURNAL ARTICLE
Faisal Aziz, Hannah Stöcher, Alexander Bräuer, Christian Ciardi, Martin Clodi, Peter Fasching, Mario Karolyi, Alexandra Kautzky-Willer, Carmen Klammer, Oliver Malle, Felix Aberer, Erich Pawelka, Slobodan Peric, Claudia Ress, Caren Sourij, Lars Stechemesser, Harald Stingl, Thomas Stulnig, Norbert Tripolt, Michael Wagner, Peter Wolf, Andreas Zitterl, Othmar Moser, Christian Schelkshorn, Susanne Kaser, Harald Sourij, For The Covid-In Diabetes In Austria
BACKGROUND: This study assessed the predictive performance of inflammatory, hepatic, coagulation, and cardiac biomarkers in patients with prediabetes and diabetes mellitus hospitalized for COVID-19 in Austria. METHODS: This was an analysis of a multicenter cohort study of 747 patients with diabetes mellitus or prediabetes hospitalized for COVID-19 in 11 hospitals in Austria. The primary outcome of this study was in-hospital mortality. The predictor variables included demographic characteristics, clinical parameters, comorbidities, use of medication, disease severity, and laboratory measurements of biomarkers...
June 13, 2022: Viruses
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JOURNAL ARTICLE
Christoph Schriefl, Christian Schoergenhofer, Nina Buchtele, Matthias Mueller, Michael Poppe, Christian Clodi, Florian Ettl, Anne Merrelaar, Magdalena Sophie Boegl, Philipp Steininger, Michael Holzer, Harald Herkner, Michael Schwameis
BACKGROUND: The clinical value of a prognostic score depends on its out-of-sample validity because inaccurate outcome prediction can be not only useless but potentially fatal. We aimed to evaluate the out-of-sample validity of a recently developed and highly accurate Korean prognostic score for predicting neurologic outcome after cardiac arrest in an independent, plausibly related sample of European cardiac arrest survivors. METHODS: Analysis of data from a European cardiac arrest center, certified in compliance with the specifications of the German Council for Resuscitation...
May 26, 2022: Journal of Personalized Medicine
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JOURNAL ARTICLE
Matthias Wolfgang Heinzl, Michael Resl, Carmen Klammer, Paul Fellinger, Lukas Schinagl, Florian Obendorf, Roland Feldbauer, Johannes Pohlhammer, Thomas Wagner, Margot Egger, Benjamin Dieplinger, Martin Clodi
Background: Current means of diagnosis of acute kidney injury (AKI) based on serum creatinine have poor sensitivity and may miss possible therapeutic windows in subclinical kidney injury, especially in septic AKI. Kidney injury molecule-1 (KIM-1) may be a valuable biomarker to improve diagnostic algorithms for AKI. The understanding of septic AKI is still insufficient, and knowledge about KIM-1 kinetics in inflammation is scarce. The aim of this study was to investigate the possible effect of lipopolysaccharide (LPS) on KIM-1 as a marker of structural kidney injury in healthy volunteers...
July 1, 2022: Shock
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RANDOMIZED CONTROLLED TRIAL
Randomized trial of three IVIg doses for treating chronic inflammatory demyelinating polyneuropathy.
David R Cornblath, Pieter A van Doorn, Hans-Peter Hartung, Ingemar S J Merkies, Hans D Katzberg, Doris Hinterberger, Elisabeth Clodi
Intravenous immunoglobulin treatment for chronic inflammatory demyelinating polyneuropathy usually starts with a 2.0 g/kg induction dose followed by 1.0 g/kg maintenance doses every 3 weeks. No dose-ranging studies with intravenous immunoglobulin maintenance therapy have been published. The Progress in Chronic Inflammatory Demyelinating polyneuropathy (ProCID) study was a prospective, double-blind, randomized, parallel-group, multicentre, phase III study investigating the efficacy and safety of 10% liquid intravenous immunoglobulin (Panzyga®) in patients with active chronic inflammatory demyelinating polyneuropathy...
April 29, 2022: Brain
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JOURNAL ARTICLE
Andressa Almeida Albuquerque, Camilla Dos Santos Mateus, Raphael de Oliveira Rodrigues, Évely Sampaio Lima, Lucas Oliveira Lima, Rayane Lima da Silva, Maria Amanda Mesquita Fernandes, Alexandre Casimiro de Macedo, Clódis Maria Tavares, Paula Sacha Frota Nogueira, Aparecida Tiemi Nagao-Dias
BACKGROUND: Serological tests for antibody measurement in leprosy have a series of limitations in discriminating contacts and patients. The present paper intends to evaluate if association of more than one antibody isotype in serum samples may be a useful tool in leprosy diagnosis. METHODS: This study evaluated 395 leprosy contacts and 71 leprosy index cases living in endemic municipalities in Northeastern Brazil. The participants were evaluated according to their anti-phenolic glycolipid antigen-I isotype (PGL-I) profile...
January 2, 2022: Pathogens and Global Health
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JOURNAL ARTICLE
Faisal Aziz, Felix Aberer, Alexander Bräuer, Christian Ciardi, Martin Clodi, Peter Fasching, Mario Karolyi, Alexandra Kautzky-Willer, Carmen Klammer, Oliver Malle, Erich Pawelka, Thomas Pieber, Slobodan Peric, Claudia Ress, Michael Schranz, Caren Sourij, Lars Stechemesser, Harald Stingl, Hannah Stöcher, Thomas Stulnig, Norbert Tripolt, Michael Wagner, Peter Wolf, Andreas Zitterl, Alexander Christian Reisinger, Jolanta Siller-Matula, Michael Hummer, Othmar Moser, Dirk von-Lewinski, Philipp Eller, Susanne Kaser, Harald Sourij
BACKGROUND: It is a matter of debate whether diabetes alone or its associated comorbidities are responsible for severe COVID-19 outcomes. This study assessed the impact of diabetes on intensive care unit (ICU) admission and in-hospital mortality in hospitalized COVID-19 patients. METHODS: A retrospective analysis was performed on a countrywide cohort of 40,632 COVID-19 patients hospitalized between March 2020 and March 2021. Data were provided by the Austrian data platform...
November 30, 2021: Viruses
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JOURNAL ARTICLE
Michael Poppe, Christian Clodi, Christoph Schriefl, Matthias Mueller, Raute Sunder-Plaßmann, Birgit Reiter, Maximilian Rechenmacher, Wisse van Os, J G Coen van Hasselt, Michael Holzer, Harald Herkner, Michael Schwameis, Bernd Jilma, Christian Schoergenhofer, Christoph Weiser
OBJECTIVE: Targeted temperature management (TTM) is part of standard post-resuscitation care. TTM may downregulate cytochrome enzyme activity and thus impact drug metabolism. This study compared the pharmacokinetics (PK) of pantoprazole, a probe drug of CYP2C19-dependent metabolism, at different stages of TTM following cardiac arrest. METHODS: This prospective controlled study was performed at the Medical University of Vienna and enrolled 16 patients following cardiac arrest...
February 2022: Biomedicine & Pharmacotherapy
#37
JOURNAL ARTICLE
Christoph Schriefl, Philipp Steininger, Christian Clodi, Matthias Mueller, Michael Poppe, Florian Ettl, Alexander Nuernberger, Juergen Grafeneder, Heidrun Losert, Michael Schwameis, Michael Holzer, Fritz Sterz, Christian Schoergenhofer
Gastrointestinal ischemia with reperfusion tissue injury contributes to post-cardiac arrest syndrome. We hypothesized that diarrhea is a symptom of intestinal ischemia/reperfusion injury and investigated whether the occurrence of early diarrhea (≤12 hours) after successful cardiopulmonary resuscitation is associated with an unfavorable neurological outcome.We analyzed data from the Vienna Clinical Cardiac Arrest Registry. Inclusion criteria comprised ≥18 years of age, a witnessed, non-traumatic out-of-hospital cardiac arrest, return of spontaneous circulation (ROSC), initial shockable rhythm, and ST-segment elevation in electrocardiogram after ROSC with consecutive coronary angiography...
December 10, 2021: Medicine (Baltimore)
#38
JOURNAL ARTICLE
Matthias Mueller, Juergen Grafeneder, Christian Schoergenhofer, Michael Schwameis, Christoph Schriefl, Michael Poppe, Christian Clodi, Moritz Koch, Fritz Sterz, Michael Holzer, Florian Ettl
Background: In cardiac arrest survivors, metabolic parameters [pH value, lactate concentration, and base deficit (BD)] are routinely added to peri-arrest factors (including age, sex, bystander cardiopulmonary resuscitation, shockable first rhythm, resuscitation duration, adrenaline dose) to enhance early outcome prediction. However, the additional value of this strategy remains unclear. Methods: We used our resuscitation database to screen all patients ≥18 years who had suffered in- or out-of-hospital cardiac arrest (IHCA, OHCA) between January 1st, 2005 and May 1st, 2019...
2021: Frontiers in Medicine
#39
Christoph Schriefl, Christian Schoergenhofer, Michael Poppe, Christian Clodi, Matthias Mueller, Florian Ettl, Bernd Jilma, Juergen Grafeneder, Michael Schwameis, Heidrun Losert, Michael Holzer, Fritz Sterz, Andrea Zeiner-Schatzl
No abstract text is available yet for this article.
September 17, 2021: Scientific Reports
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JOURNAL ARTICLE
Jozsef C Széles, Stefan Kampusch, Florian Thürk, Christian Clodi, Norbert Thomas, Severin Fichtenbauer, Christian Schwanzer, Sebastian Schwarzenberger, Christoph Neumayer, Eugenijus Kaniusas
Objective. Recent research suggests that percutaneous auricular vagus nerve stimulation (pVNS) beneficially modulates the autonomic nervous system (ANS). Bursted pVNS seems to be efficient for nerve excitation. Bursted pVNS effects on cardiac autonomic modulation are not disclosed yet. Approach. For the first time, the present study evaluates the effect of pVNS on cardiac autonomic modulation in healthy subjects ( n = 9) using two distinct bursted stimulation patterns (biphasic and triphasic stimulation) and heart rate variability analysis (HRV)...
October 29, 2021: Physiological Measurement
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