keyword
https://read.qxmd.com/read/38543909/immunogenicity-parameters-of-cancer-patients-receiving-the-mrna-vaccine-bnt162b2-while-obtaining-radiotherapy-a-longitudinal-cohort-evaluation
#1
JOURNAL ARTICLE
Paul Thöne, Margot Egger, Marija Geroldinger-Simic, Harald Kindermann, Lukas Kocik, Nicola Karasek, Barbara Fischerlehner, Kurt Spiegl, Georg Gruber, Bernhard Aschacher, Benjamin Dieplinger, Martin Clodi, Hans Geinitz
BACKGROUND: Cancer patients are highly prone to infectious diseases. While undergoing antineoplastic treatment, the risk of severe symptoms upon infection increases, necessitating efficient protective measures, such as vaccination. For patients receiving radiotherapy, there is no specific information about humoral immunity. During the COVID-19 pandemic, serial antibody measurements were therefore offered to cancer patients, following SARS-CoV-2 vaccination while obtaining radiotherapy...
March 6, 2024: Vaccines
https://read.qxmd.com/read/38233885/safety-and-tolerability-of-intravenous-immunoglobulin-in-patients-with-active-dermatomyositis-results-from-the-randomised-placebo-controlled-proderm-study
#2
RANDOMIZED CONTROLLED TRIAL
Rohit Aggarwal, Joachim Schessl, Christina Charles-Schoeman, Zsuzsanna Bata-Csörgő, Mazen M Dimachkie, Zoltan Griger, Sergey Moiseev, Chester V Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi, Todd Levine
BACKGROUND: Dermatomyositis is an idiopathic inflammatory myopathy characterised by rashes and progressive muscle weakness. The recent ProDERM (Progress in DERMatomyositis) study is the first large randomised, placebo-controlled trial to establish the efficacy and safety of intravenous immunoglobulin (IVIg) in adult patients with dermatomyositis. Objectives of this analysis were to closely examine the safety and tolerability of IVIg in patients from the ProDERM study. METHODS: ProDERM was a double-blind, randomised, placebo-controlled, multicentre, phase 3 study...
January 17, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38152237/transapical-electrosurgical-laceration-and-stabilization-of-mitral-clips-followed-by-transcatheter-mitral-valve-replacement-a-one-stop-shop
#3
JOURNAL ARTICLE
Joerg Kellermair, Ilinca Damian, Michael Grund, Georg Hagleitner, Florian Huber, Michael Resl, Gregor Sulzbacher, Martin Clodi, Clemens Steinwender, Andreas Zierer
OBJECTIVE: Electrosurgical laceration and stabilization of mitral clips (ELASTA-CLIP) is a bail-out technique to recreate a single-orifice mitral valve after transcatheter edge-to-edge repair (TEER) with subsequent transcatheter mitral valve replacement (TMVR). This technique is a novel option for patients with significant residual mitral regurgitation after TEER with high risk for conventional surgery. The original ELASTA CLIP procedure features a transseptal approach, whereas the TMVR with the Tendyne bioprosthesis has a transapical access...
December 2023: JTCVS techniques
https://read.qxmd.com/read/37821694/-overweight-and-obesity-in-adults-general-principles-of-treatment-and-conservative-management
#4
JOURNAL ARTICLE
Johanna Maria Brix, Barbara Andersen, Kadriye Aydinkoc-Tuzcu, Philipp Beckerhinn, Agnes Brossard-Eitzinger, Anna Cavini, Christian Ciardi, Martin Clodi, Marlies Eichner, Brigitte Erlacher, Markus Fahrnberger, Daniel Moritz Felsenreich, Claudia Francesconi, Bettina Göbel, Elisabeth Hölbing, Friedrich Hoppichler, Joakim Huber, Simone Leonora Huber, Bianca Karla Itariu, Birgit Jandrasitz, Florian W Kiefer, Gerd Köhler, Renate Kruschitz, Bernhard Ludvik, Andrea Malzner, Alexander Moosbrugger, Anna Öfferlbauer-Ernst, Verena Parzer, Gerhard Prager, Michael Resl, Claudia Ress, Christian Schelkshorn, Thomas Scherer, Harald Sourji, Lars Stechemesser, Thomas Stulnig, Hermann Toplak, Maria Wakolbinger, Alexander Vonbank, Daniel Weghuber
The prevalence of overweight and obesity is steadily increasing in Austria as well as internationally. Obesity in particular is associated with multiple health risks, comorbidities, functional disability, and social stigma. Obesity is an independent, complex, chronic disease and should be treated as such by a multidisciplinary team of appropriately qualified personnel. In addition to recent international guidelines, this consensus paper outlines the overall principles of the management of overweight and obesity and provides guidance for the diagnosis and conservative treatment, focusing on lifestyle modifications and pharmacotherapy...
November 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37686414/effect-of-repeated-bolus-and-continuous-glucose-infusion-on-dna-damage-and-oxidative-stress-biomarkers-in-healthy-male-volunteers
#5
JOURNAL ARTICLE
Laura Bragagna, Christina Polak, Lisa Schütz, Lina Maqboul, Carmen Klammer, Roland Feldbauer, Agnes Draxler, Martin Clodi, Karl-Heinz Wagner
Glucose variability (GV), which describes fluctuations in blood glucose levels within the day, is a phenomenon that is increasingly becoming the target of scientific attention when it comes to increased risk of coronary heart disease. Effects of GV may contribute to the development of metabolic syndrome and type 2 diabetes. Hyperglycemia can lead to oxidative stress resulting in molecular damage due to accumulation of reactive oxygen species (ROS). To discover more about the immediate effects of GV, continuous vs...
September 2, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37378806/safety-and-tolerability-of-intravenous-immunoglobulin-in-chronic-inflammatory-demyelinating-polyneuropathy-results-of-the-procid-study
#6
JOURNAL ARTICLE
David R Cornblath, Pieter A van Doorn, Hans-Peter Hartung, Ingemar S J Merkies, Hans D Katzberg, Doris Hinterberger, Elisabeth Clodi
BACKGROUND AND AIMS: The ProCID study evaluated the efficacy and safety of three doses of a 10% liquid intravenous immunoglobulin (IVIg) preparation (panzyga® ) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). This report describes the safety findings. METHODS: Patients were randomised to receive a 2.0 g/kg induction dose followed by maintenance doses of either 0.5, 1.0 or 2.0 g/kg IVIg every 3 weeks over 24 weeks. RESULTS: All 142 enrolled patients were included in the safety analyses...
June 28, 2023: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/37286910/simulation-of-bempedoic-acid-and-ezetimibe-in-the-lipid-lowering-treatment-pathway-in-austria-using-the-contemporary-santorini-cohort-of-high-and-very-high-risk-patients
#7
JOURNAL ARTICLE
Hermann Toplak, Aikaterini Bilitou, Hannes Alber, Johann Auer, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Carmen Gelsinger, Ursula Hanusch, Bernhard Ludvik, Thomas Maca, Andreas Schober, Reinhard Sock, Walter S Speidl, Thomas M Stulnig, Raimund Weitgasser, Andreas Zirlik, Marina Koch, Sebastian Wienerroither, Sorrel E Wolowacz, Françoise Diamand, Alberico L Catapano
OBJECTIVE: The low-density lipoprotein cholesterol goals in the 2019 European Society of Cardiology/European Atherosclerosis Society dyslipidaemia guidelines necessitate greater use of combination therapies. We describe a real-world cohort of patients in Austria and simulate the addition of oral bempedoic acid and ezetimibe to estimate the proportion of patients reaching goals. METHODS: Patients at high or very high cardiovascular risk on lipid-lowering treatments (excluding proprotein convertase subtilisin/kexin type 9 inhibitors) from the Austrian cohort of the observational SANTORINI study were included using specific criteria...
July 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37183852/association-between-postresuscitation-12-lead-ecg-features-and-early-mortality-after-out-of-hospital-cardiac-arrest-a-post-hoc-subanalysis-of-the-peace-study
#8
JOURNAL ARTICLE
Francesca Romana Gentile, Enrico Baldi, Catherine Klersy, Sebastian Schnaubelt, Maria Luce Caputo, Christian Clodi, Jolie Bruno, Sara Compagnoni, Alessandro Fasolino, Claudio Benvenuti, Hans Domanovits, Roman Burkart, Roberto Primi, Gerhard Ruzicka, Michael Holzer, Angelo Auricchio, Simone Savastano
Background Once the return of spontaneous circulation after out-of-hospital cardiac arrest is achieved, a 12-lead ECG is strongly recommended to identify candidates for urgent coronary angiography. ECG has no apparent role in mortality risk stratification. We aimed to assess whether ECG features could be associated with 30-day survival in patients with out-of-hospital cardiac arrest. Methods and Results All the post-return of spontaneous circulation ECGs from January 2015 to December 2018 in 3 European centers (Pavia, Lugano, and Vienna) were collected...
May 15, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/37101052/-diabetes-mellitus-and-road-traffic-a%C3%A2-position-paper-of-the-austrian-diabetes-association-update-2023
#9
JOURNAL ARTICLE
Heidemarie Abrahamian, Birgit Salamon, Angelika Lahnsteiner, Christian Schelkshorn, Alexander Bräuer, Lars Stechemesser, Gerd Köhler, Martin Clodi
Public safety (prevention of accidents) is the primary objective in assessing fitness to drive a motor vehicle. However, general access to mobility should not be restricted if there is no particular risk to public safety. For people with diabetes mellitus, the Führerscheingesetz (Driving Licence Legislation) and the Führerscheingesetz-Gesundheitsverordnung (Driving Licence Legislation Health enactment) regulate important aspects of driving safety in connection with acute and chronic complications of the disease...
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101051/-geriatric-aspects-for-the-management-of-diabetes-mellitus-update-2023
#10
JOURNAL ARTICLE
Joakim Huber, Michael Smeikal, Christoph H Saely, Harald Stingl, Martin Clodi, Monika Lechleitner, Peter Fasching
There is a high prevalence of diabetes mellitus in the elderly population of industrial countries. The present article provides recommendations for the screening, prevention and treatment of elderly diabetic patients according to current scientific evidence.
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101048/-hyperglycemia-in-critically-ill
#11
JOURNAL ARTICLE
M Clodi, M Resl, H Abrahamian, B Föger, R Weitgasser
In critical illness hyperglycemia is associated with increased mortality. Based on the currently available evidence, an intravenous insulin therapy should be initiated when blood glucose is above 180 mg/dl. After initiation of insulin therapy blood glucose should be maintained between 140 and 180 mg/dl.
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101047/-position-statement-surgery-and-diabetes-mellitus-update-2023
#12
JOURNAL ARTICLE
Antonia-Therese Kietaibl, Joakim Huber, Martin Clodi, Heidemarie Abrahamian, Bernhard Ludvik, Peter Fasching
This position statement reflects the perspective of the Austrian Diabetes Association concerning the perioperative management of people with diabetes mellitus based on the available scientific evidence. The paper covers necessary preoperative examinations from an internal/diabetological point of view as well as the perioperative metabolic control by means of oral antihyperglycemic and/or insulin therapy.
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101045/-treatment-of-acute-diabetic-metabolic-crises-in-adults-update%C3%A2-2023-hyperglycemic-hyperosmolar-state-and-ketoacidotic-metabolic-disorder
#13
JOURNAL ARTICLE
Susanne Kaser, Harald Sourij, Martin Clodi, Bruno Schneeweiß, Anton N Laggner, Anton Luger
Diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state (HHS) represent potentially life-threatening situations in adults. Therefore, rapid comprehensive diagnostic and therapeutic measures with close monitoring of vital and laboratory parameters are required. The treatment of DKA and HHS is essentially the same and replacement of the mostly substantial fluid deficit with several liters of a physiological crystalloid solution is the first and most important step. Serum potassium concentrations need to be carefully monitored to guide its substitution...
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101042/-diabetes-mellitus-coronary-artery-disease-and-heart-disease-update-2023
#14
JOURNAL ARTICLE
Martin Clodi, Christoph H Saely, Friedrich Hoppichler, Michael Resl, Clemens Steinwender, Harald Stingl, Thomas C Wascher, Yvonne Winhofer, Harald Sourij
Diabetes mellitus, cardiovascular disease and heart failure are interacting dynamically. Patients being diagnosed with cardiovascular disease should be screened for diabetes mellitus. Enhanced cardiovascular risk stratification based on biomarkers, symptoms and classical risk factors should be performed in patients with preexisting diabetes mellitus. In patients with previously diagnosed arterosclerotic cardiovascular disease an agent proven to reduce major adverse cardiovascular events or cardiovascular mortality is recommended...
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101040/-diabetic-kidney-disease-update-2023-position-paper-of-the-austrian-diabetes-association-and-the-austrian-society-for-nephrology
#15
JOURNAL ARTICLE
Harald Sourij, Roland Edlinger, Friedrich C Prischl, Susanne Kaser, Sabine Horn, Marlies Antlanger, Bernhard Paulweber, Felix Aberer, Johanna Brix, Daniel Cejka, Harald Stingl, Alexandra Kautzky-Willer, Sabine Schmaldienst, Martin Clodi, Alexander Rosenkranz, Gert Mayer, Rainer Oberbauer, Marcus Säemann
Epidemiological investigations have shown that approximately 2-3% of all Austrians have diabetes mellitus with renal involvement, leaving 250,000 people in Austria affected. The risk of occurrence and progression of this disease can be attenuated by lifestyle interventions as well as optimization of blood pressure, blood glucose control and special drug classes. The present article represents the joint recommendations of the Austrian Diabetes Association and the Austrian Society of Nephrology for the diagnostic and treatment strategies of diabetic kidney disease...
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101037/-lipids-diagnosis-and-therapy-in-diabetes-mellitus-update-2023
#16
JOURNAL ARTICLE
Thomas C Wascher, Bernhard Paulweber, Hermann Toplak, Christoph H Saely, Heinz Drexel, Bernhard Föger, Friedrich Hoppichler, Thomas Stulnig, Harald Stingl, Martin Clodi
Hyper- and dyslipidemia contribute to cardiovascular morbidity and mortality in diabetic patients. Pharmacological therapy to lower LDL cholesterol has convincingly shown to reduce cardiovascular risk in diabetic patients. The present article represents the recommendations of the Austrian Diabetes Association for the use of lipid-lowering drugs in diabetic patients according to current scientific evidence.
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101034/-diabetes-education-and-counseling-in-adult-patients-with-diabetes-update-2023
#17
JOURNAL ARTICLE
Raimund Weitgasser, Christian Ciardi, Julia Traub, Merlena Barta, Michaela Riedl, Martin Clodi, Bernhard Ludvik
Diabetes education and self-management play a critical role in diabetes care. Patient empowerment aims to actively influence the course of the disease by self-monitoring and subsequent treatment modification as well as the ability of patients to integrate diabetes into their daily life and to appropriately adapt diabetes to their life style situation. Diabetes education has to be made accessible for all persons with the disease. In order to be able to provide a structured and validated education program, adequate personnel as well as space, organizational and financial prerequisites are required...
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101030/-diagnosis-and-insulin-therapy-of-type%C3%A2-1%C3%A2-diabetes-mellitus-update-2023
#18
JOURNAL ARTICLE
Monika Lechleitner, Susanne Kaser, Friedrich Hoppichler, Michael Roden, Raimund Weitgasser, Bernhard Ludvik, Peter Fasching, Yvonne Winhofer, Alexandra Kautzky-Willer, Guntram Schernthaner, Rudolf Prager, Thomas C Wascher, Martin Clodi
This guideline summarizes diagnosis of type 1 diabetes, including accompanying autoimmune disorders, insulin therapy regimens and glycemic target values.
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101029/-obesity-and-type%C3%A2-2%C3%A2-diabetes-update-2023
#19
JOURNAL ARTICLE
Martin Clodi, Hermann Toplak, Michael Resl, Johanna Brix, Deborah Raphaela Leitner, Jürgen Harreiter, Friedrich Hoppichler, Thomas C Wascher, Karin Schindler, Bernhard Ludvik
The body mass index (BMI) is a very crude measure of body fatness in individuals. Even normal weight persons can have too much body fat in cases of a lack of muscle mass (sarcopenia), which is why additional measurements of waist circumference and body fatness, e.g. bioimpedance analysis (BIA), are recommended. Lifestyle management including nutrition modification and increase in physical activity are important measures for the prevention and treatment of diabetes. Regarding the treatment of type 2 diabetes, body weight is increasingly used as a secondary target parameter...
January 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37101026/-nutrition-for-diabetic-patients-update-2023
#20
JOURNAL ARTICLE
Carmen Klammer, Karin Schindler, Rita Bugl, Dagmar Plazek, Miriam Vötter, Tanja Kirchner, Claudia Martino, Jasmin Klammer-Martin, Johanna Brix, Sabine Dämon, Friedrich Hoppichler, Alexandra Kautzky-Willer, Renate Kruschitz, Hermann Toplak, Martin Clodi, Bernhard Ludvik
All patients with diabetes require individual and personalized nutritional consultation with professionals. The patient's needs should be the primary focus of the dietary therapy, taking their lifestyle and the type of diabetes into consideration. With the recommendations to the patient's diet, there need to be specific metabolic goals to reduce the disease's progression and to avoid long term health effects. Therefore, practical guidelines such as portion size and meal planning tips should be the main focus...
January 2023: Wiener Klinische Wochenschrift
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