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https://www.readbyqxmd.com/read/27926473/growth-differentiation-factor-15-increases-following-oral-glucose-ingestion-effect-of-meal-composition-and-obesity
#1
Marie Helene Schernthaner-Reiter, Dominik Kasses, Christina Tugendsam, Michaela Riedl, Slobodan Peric, Gerhard Prager, Michael Krebs, Miriam Promintzer-Schifferl, Martin Clodi, Anton Luger, Greisa Vila
OBJECTIVE: Growth differentiation factor 15 (GDF15) is a cardiovascular biomarker belonging to the transforming growth factor-β superfamily. Increased GDF15 concentrations are associated with insulin resistance, diabetes and obesity. We investigated the physiological effects of meal composition and obesity on the regulation of systemic GDF15 levels. DESIGN: Lean (n = 8) and obese (n = 8) individuals received a carbohydrate- or fat-rich meal, a 75 g oral glucose load (OGTT) or short-term fasting...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27756762/gdf-15-is-associated-with-cancer-incidence-in-patients-with-type-2-diabetes
#2
Noemi Pavo, Raphael Wurm, Stephanie Neuhold, Christopher Adlbrecht, Greisa Vila, Guido Strunk, Martin Clodi, Michael Resl, Helmut Brath, Rudolf Prager, Anton Luger, Richard Pacher, Martin Hülsmann
BACKGROUND: Diabetes has been linked epidemiologically to increased cancer incidence and mortality. Growth differentiation factor 15 (GDF-15) is increased in patients with diabetes and has recently been linked to the occurrence of cancer. We investigated whether circulating GDF-15 concentrations can predict the incidence of malignant diseases in a diabetic patient cohort already facing increased risk for cancer. METHODS: We prospectively enrolled a total of 919 patients with type 2 diabetes and no history of malignant disease, who were clinically followed up for 60 months...
December 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27456261/targeted-multiple-biomarker-approach-in-predicting-cardiovascular-events-in-patients-with-diabetes
#3
M Resl, M Clodi, G Vila, A Luger, S Neuhold, R Wurm, C Adlbrecht, G Strunk, M Fritzer-Szekeres, R Prager, R Pacher, M Hülsmann
OBJECTIVE: We hypothesised that biomarkers representing different pathophysiological pathways of atherosclerosis namely growth differentiation factor 15 (GDF-15), N-terminal pro B-type natriuretic peptide (NT-proBNP) and high-sensitive troponin T (hs-TnT) could enhance cardiovascular risk prediction in patients with type 2 diabetes mellitus. METHODS: This is a prospective study in 746 patients with type 2 diabetes mellitus, who were followed up for 60 months. The primary endpoint was defined as unplanned hospitalisation for cardiovascular disease or death...
July 25, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27226327/cardiovascular-safety-of-metformin-and-sulfonylureas-in-patients-with-different-cardiac-risk-profiles
#4
Raphael Wurm, Michael Resl, Stephanie Neuhold, Rudolf Prager, Helmut Brath, Claudia Francesconi, Greisa Vila, Guido Strunk, Martin Clodi, Anton Luger, Richard Pacher, Martin Hülsmann
OBJECTIVES/BACKGROUND: Based on previous experiences, the Food and Drug Administration and the European Medicines Agency recommend that clinical trials for novel antidiabetic drugs are powered to detect increased cardiovascular risk. In this context, data concerning licensed drugs such as metformin and sulfonylureas are conflicting. The influence of baseline cardiovascular risk on any treatment effect appears obvious but has not been formally proven. We therefore evaluated association of metformin and sulfonylureas with cardiovascular events in patients with different cardiovascular risk profiles indicated by N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) levels...
October 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27052250/-antihyperglycemic-treatment-guidelines-for-diabetes-mellitus-type-2
#5
Martin Clodi, Heidemarie Abrahamian, Heinz Drexel, Peter Fasching, Bernhard Föger, Claudia Francesconi, Friedrich Hoppichler, Susanne Kaser, Alexandra Kautzky-Willer, Monika Lechleitner, Bernhard Ludvik, Rudolf Prager, Elke Fröhlich-Reiterer, Michael Roden, Christoph Säly, Guntram Schernthaner, Harald Sourij, Hermann Toplak, Thomas C Wascher, Raimund Weitgasser
Hyperglycemia significantly contributes to micro- and macrovascular complications in patients with diabetes mellitus. While lifestyle interventions remain cornerstones of disease prevention and treatment, most patients with type 2 diabetes will eventually require pharmacotherapy for glycemic control. The definition of individual targets regarding optimal therapeutic efficacy and safety is of great importance. In this guideline we present the most current evidence-based best clinical practice data for healthcare professionals...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052249/-diabetes-mellitus-coronary-artery-disease-and-heart-disease
#6
Martin Clodi, Christoph Säly, Friedrich Hoppichler, Michael Resl, Clemens Steinwender, Bernd Eber
Diabetes mellitus, cardiovascular disease and heart failure are interacting dynamically. Patients being diagnosed with cardiovascular disease should be screened for diabetes mellitus. Enhanced cardiovascular risk stratification based on biomarkers, symptoms and classical risk factors should be performed in patients with pre-existing diabetes mellitus.
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052242/-diabetes-education-in-adult-diabetic-patients
#7
Raimund Weitgasser, Martin Clodi, Sarah Cvach, Peter Grafinger, Monika Lechleitner, Kinga Howorka, Bernhard Ludvik
Diabetes education and self management has gained a critical role in diabetes care. Patient empowerment aims to actively influence the course of the disease by self-monitoring and treatment modification, as well as integration of diabetes in patients' daily life to achieve changes in lifestyle accordingly.Diabetes education has to be made accessible for all patients with the disease. To be able to provide a structured and validated education program adequate personal as well as space, organizational and financial background are required...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052241/-position-statement-surgery-and-diabetes-mellitus
#8
Peter Fasching, Joakim Huber, Martin Clodi, Heidemarie Abrahamian, Bernhard Ludvik
This position statement reflects the opinion of the Austrian Diabetes Association concerning the perioperative management of patients with diabetes mellitus based on the available scientific evidence. The paper covers necessary preoperative examinations from an internal/diabetological point of view as well as the perioperative metabolic control by means of oral antidiabetics and/or insulin therapy.
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052236/-exocrine-pancreatic-insufficiency-and-diabetes-mellitus
#9
Raimund Weitgasser, Heidemarie Abrahamian, Martin Clodi, Sandra Zlamal-Fortunat, Heinz F Hammer
Exocrine pancreatic insufficiency (EPI) in diabetic patients is frequent. Studies based on fecal elastase-1 measurement give prevalence rates of 10‒30 % of severe and 22‒56 % of moderate EPI in type 1 and rates of 5‒46 % in type 2 diabetic patients. Nevertheless, not all patients report typical symptoms like diarrhea, steatorrhea and weight loss. For noninvasive testing the determination of fecal elastase-1 has the highest sensitivity and specificity. This test should be performed at least in all symptomatic patients...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052234/-treatment-of-hyperglycemia-in-adult-critically-ill-patients
#10
Martin Clodi, Michael Resl, Heidemarie Abrahamian, Bernhard Föger, Raimund Weitgasser
In critical illness hyperglycemia is associated with increased mortality. Based on the currently available evidence, an intravenous insulin therapy should be initiated when blood glucose is above 180 mg/dl. After initiation of insulin therapy blood glucose should be maintained between 140 and 180 mg/dl.
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052231/-diabetic-kidney-disease-update-2016
#11
Harald Sourij, Roland Edlinger, Friedrich Prischl, Martin Auinger, Alexandra Kautzky-Willer, Marcus D Säemann, Rudolf Prager, Martin Clodi, Guntram Schernthaner, Gert Mayer, Rainer Oberbauer, Alexander R Rosenkranz
Recent epidemiological evaluations have shown that approximately 5% of all Austrians suffer from diabetes including renal involvement, i. e. 400.000 people in Austria are affected. The risk of start and progression of this disease can be ameliorated by lifestyle interventions as well as optimization of blood pressure and glucose levels. The present article represents the joint recommendations of the Austrian Diabetes Association and the Austrian Society for Nephrology for the prevention and treatment of diabetic kidney disease...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/26299586/lactation-and-appetite-regulating-hormones-increased-maternal-plasma-peptide-yy-concentrations-3-6-months-postpartum
#12
Greisa Vila, Judith Hopfgartner, Gabriele Grimm, Sabina M Baumgartner-Parzer, Alexandra Kautzky-Willer, Martin Clodi, Anton Luger
Breast-feeding is associated with maternal hormonal and metabolic changes ensuring adequate milk production. In this study, we investigate the impact of breast-feeding on the profile of changes in maternal appetite-regulating hormones 3-6 months postpartum. Study participants were age- and BMI-matched lactating mothers (n 10), non-lactating mothers (n 9) and women without any history of pregnancy or breast-feeding in the previous 12 months (control group, n 10). During study sessions, young mothers breast-fed or bottle-fed their babies, and maternal blood samples were collected at five time points during 90 min: before, during and after feeding the babies...
October 28, 2015: British Journal of Nutrition
https://www.readbyqxmd.com/read/25539929/effects-of-b-type-natriuretic-peptide-on-cardiovascular-biomarkers-in-healthy-volunteers
#13
RANDOMIZED CONTROLLED TRIAL
M Resl, G Vila, G Grimm, B Heinisch, M Riedl, B Dieplinger, T Mueller, A Luger, M Clodi
Cardiovascular biomarkers provide independent prognostic information in the assessment of mortality and cardiovascular complications. However, little is known about possible interactions between these biomarkers. In the present study, we evaluated the influence of B-type natriuretic peptide (BNP) on midregional-proadrenomedullin (MR-proADM), C-terminal-proendothelin-1 (CT-proET-1), growth differentiation factor-15 (GDF-15), midregional-proatrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin in healthy volunteers...
February 15, 2015: Journal of Applied Physiology
https://www.readbyqxmd.com/read/24188329/association-of-endostatin-with-mortality-in-patients-with-chronic-heart-failure
#14
Ghazaleh Gouya, Jolanta M Siller-Matula, Monika Fritzer-Szekeres, Stephanie Neuhold, Angela Storka, Lisa M Neuhofer, Martin Clodi, Martin Hülsmann, Richard Pacher, Michael Wolzt
BACKGROUND: Experimental data imply that in decompensated heart failure (HF), the anti-angiogenic factor endostatin is increased. This study aimed to investigate whether the angiogenesis inhibitor endostatin is related to the risk of all-cause mortality in a prospective cohort study of chronic HF patients. METHODS: In this prospective observational cohort study, endostatin serum concentrations were determined in patients with chronic HF. Mortality data were recorded during a median follow-up of 31 months...
February 2014: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/24061697/estimated-glomerular-filtration-rate-and-albuminuria-true-predictors-of-cardiovascular-events-in-obese-patients-with-type-2-diabetes
#15
Michael Resl, Greisa Vila, Roland Kraxner, Richard Pacher, Anton Luger, Martin Hülsmann, Stephanie Neuhold, Helmut Brath, Rudolf Prager, Martin Clodi
BACKGROUND: The widely used MDRD formula underestimates kidney function in obese patients with diabetes mellitus. Therefore we aimed to evaluate the predictive value of estimated glomerular filtration rate (eGFR) for cardiovascular events in a typical cohort of patients with diabetes mellitus. METHODS: A total of 988 patients were analyzed. Cox regression models including the variables HbA1c, age, duration of diabetes, eGFR and urinary albumin to creatinine ratio (UACR) were run...
October 2013: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/23810874/pontiac-nt-probnp-selected-prevention-of-cardiac-events-in-a-population-of-diabetic-patients-without-a-history-of-cardiac-disease-a-prospective-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Martin Huelsmann, Stephanie Neuhold, Michael Resl, Guido Strunk, Helmut Brath, Claudia Francesconi, Christopher Adlbrecht, Rudolf Prager, Anton Luger, Richard Pacher, Martin Clodi
OBJECTIVES: The study sought to assess the primary preventive effect of neurohumoral therapy in high-risk diabetic patients selected by N-terminal pro-B-type natriuretic peptide (NT-proBNP). BACKGROUND: Few clinical trials have successfully demonstrated the prevention of cardiac events in patients with diabetes. One reason for this might be an inaccurate selection of patients. NT-proBNP has not been assessed in this context. METHODS: A total of 300 patients with type 2 diabetes, elevated NT-proBNP (>125 pg/ml) but free of cardiac disease were randomized...
October 8, 2013: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/23262748/-antihyperglycemic-treatment-guidelines-for-diabetes-mellitus-type-2
#17
Martin Clodi, H Eidemarie Abrahamian, Heinz Drexel, Peter Fasching, Friedrich Hoppichler, Alexandra Kautzky-Willer, Monika Lechleitner, Bernhard Ludvik, Rudolf Prager, Michael Roden, Christoph Saely, Guntram Schernthaner, Edith Schober, Hermann Toplak, Thomas Wascher, Raimund Weitgasser
Hyperglycemia significantly contributes to micro- and macrovascular complications in patients with diabetes mellitus. While lifestyle interventions remain cornerstones of disease prevention and treatment, most patients with type 2 diabetes will eventually require pharmacotherapy for glycemic control. The definition of individual targets in regard of optimal therapeutic efficacy and high therapeutic safety is of great importance. In this guideline we present the best and most current evidence-based clinical practice data for healthcare professionals...
December 2012: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/23262747/-diabetic-nephropathy-update-2012
#18
Martin Auinger, Roland Edlinger, Friedrich Prischl, Alexandra Kautzky-Willer, Rudolf Prager, Alexander R Rosenkranz, Michael Roden, Marcus Saemann, Martin Clodi, Guntram Schernthaner
Diabetes mellitus is the leading single cause for renal replacement therapy. Its development and progression, however, can be ameliorated by adequate therapy. The present article represents the recommendations of the Austrian Diabetes Association and the Austrian Society for Nephrology for the prevention and treatment of diabetic nephropathy.
December 2012: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/23250472/-position-paper-exocrine-pancreatic-insufficiency-and-diabetes-mellitus
#19
Raimund Weitgasser, Heidemarie Abrahamian, Martin Clodi, Werner Fortunat, Heinz Hammer
Exocrine pancreatic insufficiency in diabetic patients is frequent. Studies based on fecal elastase-1 measurement give prevalence rates of about 50 % in type 1 and 33 % in type 2 diabetic patients. Nevertheless, not all patients report typical symptoms like diarrhea, steatorrhea and weight loss. For indirect testing the determination of fecal elastase-1 has the highest sensitivity and specificity. This test should be performed at least in all symptomatic patients. For differential diagnosis celiac disease (with a prevalence of about 3-5 % of type 1 diabetic patients), autonomic neuropathy, but also diseases like irritable colon and gastrointestinal tumors have to be taken into account...
December 2012: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/23250471/-diabetes-education-in-adult-diabetic-patients
#20
Raimund Weitgasser, Martin Clodi, Gertrud Kacerovsky-Bielesz, Peter Grafinger, Monika Lechleitner, Kinga Howorka, Bernhard Ludvik
Diabetes education has gained a critical role in diabetes care. The empowerment of patients aims to actively influence the course of the disease by self-monitoring and treatment modification. Diabetes education has to be made accessible for all patients with the disease. To be able to provide a structured and validated education program adequate personal as well as space, organizational and financial background are required. Besides an increase in knowledge about the disease it has been shown that structured diabetes education is able to improve diabetes outcome measured by parameters like blood glucose, HbA1c, blood pressure and body weight in follow-up evaluations...
December 2012: Wiener Klinische Wochenschrift
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