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https://www.readbyqxmd.com/read/28602616/salivary-anti-pgl-1-igm-may-indicate-active-transmission-of-mycobacterium-leprae-among-young-people-under-16-years-of-age
#1
Alexandre Casimiro de Macedo, José Evandro Cunha, Juliana Navarro Ueda Yaochite, Clodis Maria Tavares, Aparecida Tiemi Nagao-Dias
Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State - Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibodies levels...
June 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28594117/serum-anti-phenolic-glycolipid-1-iga-correlates-to-igm-isotype-in-leprosy-patients-a-possible-candidate-for-seroepidemiological-surveys
#2
Alexandre C de Macedo, Juliana A Guimarães, Raphael O Rodrigues, Thiago D V Araújo, Clodis M Tavares, Paula B Cabral, Maria Isabel de Moraes-Pinto, Aparecida T Nagao-Dias
OBJECTIVE: The aim of this study was to compare serum anti-phenolic glycolipid-1 IgA, IgG, and IgM levels in leprosy patients and controls. METHOD: Analysis of anti-PGL-1 IgA, IgG, or IgM in serum samples from multibacillary (MB, n=32) and paucibacillary (PB, n=22) leprosy patients, and in non-endemic controls (n=17), using an indirect enzyme-linked immunosorbent assay. RESULTS: A strong correlation between serum IgM and IgA isotypes was found (r=...
June 8, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28562481/extracorporeal-life-support-increases-survival-after-prolonged-ventricular-fibrillation-cardiac-arrest-in-the-rat
#3
Ingrid Anna Maria Magnet, Florian Ettl, Andreas Schober, Alexandra-Maria Warenits, Daniel Grassmann, Michael Wagner, Christoph Schriefl, Christian Clodi, Ursula Teubenbacher, Sandra Högler, Wolfgang Weihs, Fritz Sterz, Andreas Janata
BACKGROUND: Extracorporeal life support (ECLS) for cardiopulmonary resuscitation (CPR) may increase end organ perfusion and thus survival when conventional CPR fails. The aim was to investigate, if after ventricular fibrillation cardiac arrest in rodents ECLS improves outcome compared to conventional CPR. METHODS: In 24 adult male Sprague-Dawley rats (460 to 510 g) resuscitation was started after 10 min of no-flow with ECLS (consisting of an open reservoir, roller pump and membrane oxygenator, connected to a cannulas in the jugular vein and femoral artery, n = 8) or CPR (mechanical chest compressions plus ventilations, n = 8) and compared to a sham group (n = 8)...
May 29, 2017: Shock
https://www.readbyqxmd.com/read/28150164/-palliative-care-consultation-in-the-icu-descriptive-analysis-of-internal-medicine-intensive-care-using-a%C3%A2-mixed-model-over-12%C3%A2-months
#4
K Lenz, B Hofmann-Bichler, J Pihringer, F Firlinger, A Pickl, M Clodi
We retrospectively analyzed the data of 56 of 669 critically ill patients admitted to an internal medicine intensive care unit (ICU) with palliative care provided by a palliative care team over the period of 12 months. For delivering palliative care, we used a mixed model-consisting of both integrative and consultative elements. SAPS III severity score in patients with palliative care was 63 ± 15 compared to 50 ± 15 in all critically ill patients. Hospital mortality was 62.5 vs. 16%. After 3 months, 19...
February 1, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28008098/b-type-natriuretic-peptide-increases-cortisol-and-catecholamine-concentrations-in-healthy-subjects
#5
Gabriele Grimm, Michael Resl, Birgit B Heinisch, Martin Hülsmann, Anton Luger, Martin Clodi, Greisa Vila
B-type natriuretic peptide (BNP) is a hormone released by the heart in response to volume load and exerts natriuretic properties. It is clinically used as a diagnostic and prognostic biomarker, and investigated as a pharmacological agent in the therapy of heart failure. Here we investigate the changes in pituitary, adrenal and thyroid hormones in response to BNP administration in a randomized single-blinded cross-over study conducted in ten healthy men aged 21-29 years. Participants received in two study sessions a continuous intravenous infusion during four hours (once placebo and once three pmol/kg/min BNP) and remained in supine position throughout the study...
December 22, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27926473/growth-differentiation-factor-15-increases-following-oral-glucose-ingestion-effect-of-meal-composition-and-obesity
#6
RANDOMIZED CONTROLLED TRIAL
Marie Helene Schernthaner-Reiter, Dominik Kasses, Christina Tugendsam, Michaela Riedl, Slobodan Peric, Gerhard Prager, Michael Krebs, Miriam Promintzer-Schifferl, Martin Clodi, Anton Luger, Greisa Vila
OBJECTIVE: Growth differentiation factor 15 (GDF15) is a cardiovascular biomarker belonging to the transforming growth factor-β superfamily. Increased GDF15 concentrations are associated with insulin resistance, diabetes and obesity. We investigated the physiological effects of meal composition and obesity on the regulation of systemic GDF15 levels. DESIGN: Lean (n = 8) and obese (n = 8) individuals received a carbohydrate- or fat-rich meal, a 75 g oral glucose load (OGTT) or short-term fasting...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27756762/gdf-15-is-associated-with-cancer-incidence-in-patients-with-type-2-diabetes
#7
Noemi Pavo, Raphael Wurm, Stephanie Neuhold, Christopher Adlbrecht, Greisa Vila, Guido Strunk, Martin Clodi, Michael Resl, Helmut Brath, Rudolf Prager, Anton Luger, Richard Pacher, Martin Hülsmann
BACKGROUND: Diabetes has been linked epidemiologically to increased cancer incidence and mortality. Growth differentiation factor 15 (GDF-15) is increased in patients with diabetes and has recently been linked to the occurrence of cancer. We investigated whether circulating GDF-15 concentrations can predict the incidence of malignant diseases in a diabetic patient cohort already facing increased risk for cancer. METHODS: We prospectively enrolled a total of 919 patients with type 2 diabetes and no history of malignant disease, who were clinically followed up for 60 months...
December 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27456261/targeted-multiple-biomarker-approach-in-predicting-cardiovascular-events-in-patients-with-diabetes
#8
M Resl, M Clodi, G Vila, A Luger, S Neuhold, R Wurm, C Adlbrecht, G Strunk, M Fritzer-Szekeres, R Prager, R Pacher, M Hülsmann
OBJECTIVE: We hypothesised that biomarkers representing different pathophysiological pathways of atherosclerosis namely growth differentiation factor 15 (GDF-15), N-terminal pro B-type natriuretic peptide (NT-proBNP) and high-sensitive troponin T (hs-TnT) could enhance cardiovascular risk prediction in patients with type 2 diabetes mellitus. METHODS: This is a prospective study in 746 patients with type 2 diabetes mellitus, who were followed up for 60 months. The primary endpoint was defined as unplanned hospitalisation for cardiovascular disease or death...
December 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27226327/cardiovascular-safety-of-metformin-and-sulfonylureas-in-patients-with-different-cardiac-risk-profiles
#9
MULTICENTER STUDY
Raphael Wurm, Michael Resl, Stephanie Neuhold, Rudolf Prager, Helmut Brath, Claudia Francesconi, Greisa Vila, Guido Strunk, Martin Clodi, Anton Luger, Richard Pacher, Martin Hülsmann
OBJECTIVES/BACKGROUND: Based on previous experiences, the Food and Drug Administration and the European Medicines Agency recommend that clinical trials for novel antidiabetic drugs are powered to detect increased cardiovascular risk. In this context, data concerning licensed drugs such as metformin and sulfonylureas are conflicting. The influence of baseline cardiovascular risk on any treatment effect appears obvious but has not been formally proven. We therefore evaluated association of metformin and sulfonylureas with cardiovascular events in patients with different cardiovascular risk profiles indicated by N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) levels...
October 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27052250/-antihyperglycemic-treatment-guidelines-for-diabetes-mellitus-type-2
#10
Martin Clodi, Heidemarie Abrahamian, Heinz Drexel, Peter Fasching, Bernhard Föger, Claudia Francesconi, Friedrich Hoppichler, Susanne Kaser, Alexandra Kautzky-Willer, Monika Lechleitner, Bernhard Ludvik, Rudolf Prager, Elke Fröhlich-Reiterer, Michael Roden, Christoph Säly, Guntram Schernthaner, Harald Sourij, Hermann Toplak, Thomas C Wascher, Raimund Weitgasser
Hyperglycemia significantly contributes to micro- and macrovascular complications in patients with diabetes mellitus. While lifestyle interventions remain cornerstones of disease prevention and treatment, most patients with type 2 diabetes will eventually require pharmacotherapy for glycemic control. The definition of individual targets regarding optimal therapeutic efficacy and safety is of great importance. In this guideline we present the most current evidence-based best clinical practice data for healthcare professionals...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052249/-diabetes-mellitus-coronary-artery-disease-and-heart-disease
#11
REVIEW
Martin Clodi, Christoph Säly, Friedrich Hoppichler, Michael Resl, Clemens Steinwender, Bernd Eber
Diabetes mellitus, cardiovascular disease and heart failure are interacting dynamically. Patients being diagnosed with cardiovascular disease should be screened for diabetes mellitus. Enhanced cardiovascular risk stratification based on biomarkers, symptoms and classical risk factors should be performed in patients with pre-existing diabetes mellitus.
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052242/-diabetes-education-in-adult-diabetic-patients
#12
REVIEW
Raimund Weitgasser, Martin Clodi, Sarah Cvach, Peter Grafinger, Monika Lechleitner, Kinga Howorka, Bernhard Ludvik
Diabetes education and self management has gained a critical role in diabetes care. Patient empowerment aims to actively influence the course of the disease by self-monitoring and treatment modification, as well as integration of diabetes in patients' daily life to achieve changes in lifestyle accordingly.Diabetes education has to be made accessible for all patients with the disease. To be able to provide a structured and validated education program adequate personal as well as space, organizational and financial background are required...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052241/-position-statement-surgery-and-diabetes-mellitus
#13
REVIEW
Peter Fasching, Joakim Huber, Martin Clodi, Heidemarie Abrahamian, Bernhard Ludvik
This position statement reflects the opinion of the Austrian Diabetes Association concerning the perioperative management of patients with diabetes mellitus based on the available scientific evidence. The paper covers necessary preoperative examinations from an internal/diabetological point of view as well as the perioperative metabolic control by means of oral antidiabetics and/or insulin therapy.
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052236/-exocrine-pancreatic-insufficiency-and-diabetes-mellitus
#14
REVIEW
Raimund Weitgasser, Heidemarie Abrahamian, Martin Clodi, Sandra Zlamal-Fortunat, Heinz F Hammer
Exocrine pancreatic insufficiency (EPI) in diabetic patients is frequent. Studies based on fecal elastase-1 measurement give prevalence rates of 10‒30 % of severe and 22‒56 % of moderate EPI in type 1 and rates of 5‒46 % in type 2 diabetic patients. Nevertheless, not all patients report typical symptoms like diarrhea, steatorrhea and weight loss. For noninvasive testing the determination of fecal elastase-1 has the highest sensitivity and specificity. This test should be performed at least in all symptomatic patients...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052234/-treatment-of-hyperglycemia-in-adult-critically-ill-patients
#15
REVIEW
Martin Clodi, Michael Resl, Heidemarie Abrahamian, Bernhard Föger, Raimund Weitgasser
In critical illness hyperglycemia is associated with increased mortality. Based on the currently available evidence, an intravenous insulin therapy should be initiated when blood glucose is above 180 mg/dl. After initiation of insulin therapy blood glucose should be maintained between 140 and 180 mg/dl.
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27052231/-diabetic-kidney-disease-update-2016
#16
REVIEW
Harald Sourij, Roland Edlinger, Friedrich Prischl, Martin Auinger, Alexandra Kautzky-Willer, Marcus D Säemann, Rudolf Prager, Martin Clodi, Guntram Schernthaner, Gert Mayer, Rainer Oberbauer, Alexander R Rosenkranz
Recent epidemiological evaluations have shown that approximately 5% of all Austrians suffer from diabetes including renal involvement, i. e. 400.000 people in Austria are affected. The risk of start and progression of this disease can be ameliorated by lifestyle interventions as well as optimization of blood pressure and glucose levels. The present article represents the joint recommendations of the Austrian Diabetes Association and the Austrian Society for Nephrology for the prevention and treatment of diabetic kidney disease...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/26299586/lactation-and-appetite-regulating-hormones-increased-maternal-plasma-peptide-yy-concentrations-3-6-months-postpartum
#17
Greisa Vila, Judith Hopfgartner, Gabriele Grimm, Sabina M Baumgartner-Parzer, Alexandra Kautzky-Willer, Martin Clodi, Anton Luger
Breast-feeding is associated with maternal hormonal and metabolic changes ensuring adequate milk production. In this study, we investigate the impact of breast-feeding on the profile of changes in maternal appetite-regulating hormones 3-6 months postpartum. Study participants were age- and BMI-matched lactating mothers (n 10), non-lactating mothers (n 9) and women without any history of pregnancy or breast-feeding in the previous 12 months (control group, n 10). During study sessions, young mothers breast-fed or bottle-fed their babies, and maternal blood samples were collected at five time points during 90 min: before, during and after feeding the babies...
October 28, 2015: British Journal of Nutrition
https://www.readbyqxmd.com/read/25539929/effects-of-b-type-natriuretic-peptide-on-cardiovascular-biomarkers-in-healthy-volunteers
#18
RANDOMIZED CONTROLLED TRIAL
M Resl, G Vila, G Grimm, B Heinisch, M Riedl, B Dieplinger, T Mueller, A Luger, M Clodi
Cardiovascular biomarkers provide independent prognostic information in the assessment of mortality and cardiovascular complications. However, little is known about possible interactions between these biomarkers. In the present study, we evaluated the influence of B-type natriuretic peptide (BNP) on midregional-proadrenomedullin (MR-proADM), C-terminal-proendothelin-1 (CT-proET-1), growth differentiation factor-15 (GDF-15), midregional-proatrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin in healthy volunteers...
February 15, 2015: Journal of Applied Physiology
https://www.readbyqxmd.com/read/24188329/association-of-endostatin-with-mortality-in-patients-with-chronic-heart-failure
#19
Ghazaleh Gouya, Jolanta M Siller-Matula, Monika Fritzer-Szekeres, Stephanie Neuhold, Angela Storka, Lisa M Neuhofer, Martin Clodi, Martin Hülsmann, Richard Pacher, Michael Wolzt
BACKGROUND: Experimental data imply that in decompensated heart failure (HF), the anti-angiogenic factor endostatin is increased. This study aimed to investigate whether the angiogenesis inhibitor endostatin is related to the risk of all-cause mortality in a prospective cohort study of chronic HF patients. METHODS: In this prospective observational cohort study, endostatin serum concentrations were determined in patients with chronic HF. Mortality data were recorded during a median follow-up of 31 months...
February 2014: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/24061697/estimated-glomerular-filtration-rate-and-albuminuria-true-predictors-of-cardiovascular-events-in-obese-patients-with-type-2-diabetes
#20
Michael Resl, Greisa Vila, Roland Kraxner, Richard Pacher, Anton Luger, Martin Hülsmann, Stephanie Neuhold, Helmut Brath, Rudolf Prager, Martin Clodi
BACKGROUND: The widely used MDRD formula underestimates kidney function in obese patients with diabetes mellitus. Therefore we aimed to evaluate the predictive value of estimated glomerular filtration rate (eGFR) for cardiovascular events in a typical cohort of patients with diabetes mellitus. METHODS: A total of 988 patients were analyzed. Cox regression models including the variables HbA1c, age, duration of diabetes, eGFR and urinary albumin to creatinine ratio (UACR) were run...
October 2013: Wiener Klinische Wochenschrift
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