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https://www.readbyqxmd.com/read/28806860/patient-caregiver-and-provider-perceptions-of-pain-and-pain-management-in-adolescents-and-young-adults-with-bleeding-disorders
#1
Angela Lambing, Cynthia D Nichols, James E Munn, Terry L Anderson, Bartholomew J Tortella, Michelle L Witkop
INTRODUCTION: Recurrent bleeding and associated pain are critical components in the management of bleeding disorders, yet scant data describe perceptions of pain in this patient population. OBJECTIVE: This study assessed perceptions of pain and pain management in adolescents and young adults (AYAs) with haemophilia or von Willebrand disease (VWD) to determine agreement/disagreement between patients, caregivers and health care providers. METHODS: Using an online questionnaire, AYA patients (N=89), their caregivers (N=77), and providers (N=54) reported on pain perception, pain treatment and pain control...
August 14, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28806817/the-effects-of-cannabis-among-adults-with-chronic-pain-and-an-overview-of-general-harms-a-systematic-review
#2
Shannon M Nugent, Benjamin J Morasco, Maya E O'Neil, Michele Freeman, Allison Low, Karli Kondo, Camille Elven, Bernadette Zakher, Makalapua Motu'apuaka, Robin Paynter, Devan Kansagara
Background: Cannabis is increasingly available for the treatment of chronic pain, yet its efficacy remains uncertain. Purpose: To review the benefits of plant-based cannabis preparations for treating chronic pain in adults and the harms of cannabis use in chronic pain and general adult populations. Data Sources: MEDLINE, Cochrane Database of Systematic Reviews, and several other sources from database inception to March 2017. Study Selection: Intervention trials and observational studies, published in English, involving adults using plant-based cannabis preparations that reported pain, quality of life, or adverse effect outcomes...
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806809/intensive-blood-pressure-treatment-in-adults-aged-60-years-or-older
#3
Jessica Weiss, Devan Kansagara
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806808/intensive-blood-pressure-treatment-in-adults-aged-60-years-or-older
#4
Gulistan Bahat, Birkan Ilhan, Asli Tufan, Mehmet Akif Karan
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806807/pharmacologic-treatment-of-hypertension-in-adults-aged-60-years-or-older
#5
Devan Kansagara, Timothy J Wilt, Jennifer Frost, Amir Qaseem
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806806/pharmacologic-treatment-of-hypertension-in-adults-aged-60-years-or-older
#6
Doreen M Rabi, Stella S Daskalopoulou, Alexander A Leung, George Dresser, Raj Padwal, Nadia Khan
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806805/pharmacologic-treatment-of-hypertension-in-adults-aged-60-years-or-older
#7
William C Cushman, Karen C Johnson, William B Applegate, Jeffrey A Cutler
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806795/in-older-adults-with-subclinical-hypothyroidism-levothyroxine-did-not-improve-symptoms-or-tiredness
#8
Reema Shah
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806794/benefits-and-harms-of-plant-based-cannabis-for-posttraumatic-stress-disorder-a-systematic-review
#9
Maya E O'Neil, Shannon M Nugent, Benjamin J Morasco, Michele Freeman, Allison Low, Karli Kondo, Bernadette Zakher, Camille Elven, Makalapua Motu'apuaka, Robin Paynter, Devan Kansagara
Background: Cannabis is available from medical dispensaries for treating posttraumatic stress disorder (PTSD) in many states of the union, yet its efficacy in treating PTSD symptoms remains uncertain. Purpose: To identify ongoing studies and review existing evidence regarding the benefits and harms of plant-based cannabis preparations in treating PTSD in adults. Data Sources: MEDLINE, the Cochrane Library, and other sources from database inception to March 2017...
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806788/chronic-unpredictable-stress-exacerbates-surgery-induced-sickness-behavior-and-neuroinflammatory-responses-via-glucocorticoids-secretion-in-adult-rats
#10
Na Wang, Hong Ma, Zhe Li, Yalei Gao, Xuezhao Cao, Yanhua Jiang, Yongjian Zhou, Sidan Liu
METHODS: Sprague-Dawley adult male rats (12-14 weeks old) were exposed to 14-day CUS and then subjected to partial hepatectomy 24 h after the last stress session. The rats were pretreated with an antagonist of the glucocorticoids (GCs) receptor RU486 (30 mg/kg, i.p.) 1 h prior to stress exposure. The behavioral changes were evaluated with open field test and elevated plus-maze test. The hippocampal cytokines interleukin (IL)-1β and IL-6 were measured on postoperative days 1, 3 and 7...
2017: PloS One
https://www.readbyqxmd.com/read/28806753/accelerometer-derived-physical-activity-and-sedentary-time-by-cancer-type-in-the-united-states
#11
Keith M Thraen-Borowski, Keith P Gennuso, Lisa Cadmus-Bertram
The 2003-2004 and 2005-2006 cycles of the National Health and Nutrition Examination Survey (NHANES) were among the first population-level studies to incorporate objectively measured physical activity and sedentary behavior, allowing for greater understanding of these behaviors. However, there has yet to be a comprehensive examination of these data in cancer survivors, including short- and long-term survivors of all cancer types. Therefore, the purpose of this analysis was to use these data to describe activity behaviors in short- and long-term cancer survivors of various types...
2017: PloS One
https://www.readbyqxmd.com/read/28806752/the-escrt-iii-pathway-facilitates-cardiomyocyte-release-of-cbin1-containing-microparticles
#12
Bing Xu, Ying Fu, Yan Liu, Sosse Agvanian, Robert C Wirka, Rachel Baum, Kang Zhou, Robin M Shaw, TingTing Hong
Microparticles (MPs) are cell-cell communication vesicles derived from the cell surface plasma membrane, although they are not known to originate from cardiac ventricular muscle. In ventricular cardiomyocytes, the membrane deformation protein cardiac bridging integrator 1 (cBIN1 or BIN1+13+17) creates transverse-tubule (t-tubule) membrane microfolds, which facilitate ion channel trafficking and modulate local ionic concentrations. The microfold- generated microdomains continuously reorganize, adapting in response to stress to modulate the calcium signaling apparatus...
August 14, 2017: PLoS Biology
https://www.readbyqxmd.com/read/28806743/correction-gene-expression-and-immunohistochemical-analyses-of-mkast-suggest-its-late-pupal-and-adult-specific-functions-in-the-honeybee-brain
#13
Atsuhiro Yamane, Hiroki Kohno, Tsubomi Ikeda, Kumi Kaneko, Atsushi Ugajin, Toshiyuki Fujita, Takekazu Kunieda, Takeo Kubo
[This corrects the article DOI: 10.1371/journal.pone.0176809.].
2017: PloS One
https://www.readbyqxmd.com/read/28806741/risk-of-cancer-in-patients-with-genital-warts-a-nationwide-population-based-cohort-study-in-taiwan
#14
Ching-Yi Cho, Yu-Cheng Lo, Miao-Chiu Hung, Chou-Cheng Lai, Chun-Jen Chen, Keh-Gong Wu
BACKGROUND: Condyloma acuminata currently affects around 1% of sexually active adults, and its incidence is increasing. The coexistence of genital warts (GW) and certain cancers and an association between human papillomavirus (HPV) and various malignancies have been reported. Therefore, we conducted this large national study to analyze the risk of malignancies among men and women with GW in Taiwan. METHODS AND FINDINGS: Between January 2000 and December 2013, approximately 3 million patients were reported to the National Health Insurance Research Database of Taiwan...
2017: PloS One
https://www.readbyqxmd.com/read/28806734/mental-health-among-single-and-partnered-parents-in-south-korea
#15
Kyoung Ae Kong, Hee Yeon Choi, Soo In Kim
OBJECTIVE: This study compares the mental health of single parents relative to partnered parents and assesses the contribution of the social and demographic factors to this difference, examining the gender difference in it. METHODS: We analyzed 12,024 single and partnered subjects, aged 30-59 years, living with children, aged 0-19 years, drawn from the 4th, 5th, and 6th Korea National Health and Nutrition Examination Survey (KNHANES) dataset in South Korea conducted from 2007-2013...
2017: PloS One
https://www.readbyqxmd.com/read/28806723/prevalence-and-location-of-tobacco-smoke-exposure-outside-the-home-in-adults-and-children-in-the-united-states
#16
M R Torok, J P Winickoff, R C McMillen, J D Klein, K M Wilson
OBJECTIVES: Tobacco smoke exposure (TSE) is associated with many adverse health outcomes. The goal of this study was to provide insight into the prevalence and location of self-reported TSE outside the home for US adults and children. STUDY DESIGN: Cross-sectional survey. METHODS: Data from a nationally representative sample of US adults from 2014 were included. Participants who responded that they smelled smoke during the past seven days in various settings were considered to have been exposed to TSE...
August 11, 2017: Public Health
https://www.readbyqxmd.com/read/28806711/the-potential-of-an-automated-system-to-identify-the-upper-limb-component-of-a-controlled-sitting-posture
#17
María B Sánchez, Ian Loram, John Darby, Paul Holmes, Penelope B Butler
Full trunk control in sitting is demonstrated only when the head-trunk are aligned and upper limbs remain free of contact from mechanical support. These components represent a Controlled Kinetic Chain and can be evaluated in people with neuromotor disability using the Segmental Assessment of Trunk Control (SATCo) when a therapist provides manual trunk support at different segmental levels. However, the SATCo, as with other clinical assessments of control, is subjective. The SATCo was translated to objective rules relating the position of the hands and elbows to the head-trunk and then tested to determine the extent to which this automated objective method replicated the clinical judgement...
August 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28806710/foot-strike-pattern-in-children-during-shod-unshod-running
#18
Pedro Ángel Latorre Román, Fernando Redondo Balboa, Felipe García Pinillos
The purpose of this study was to determine the foot strike patterns (FSPs) and neutral support (no INV/EVE and no foot rotation) in children, as well as to determine the influence of shod/unshod conditions and sex. A total of 713 children, aged 6 to 16 years, participated in this study (Age=10.28±2.71years, body mass index [BMI]=19.70±3.91kg/m(2), 302 girls and 411 boys). A sagittal and frontal-plane video (240Hz) was recorded using a high-speed camcorder, to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/eversion (INV/EVE) and foot rotation on initial contact...
August 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28806639/a-developmental-etiological-model-for-drug-abuse-in-men
#19
Kenneth S Kendler, Henrik Ohlsson, Alexis C Edwards, Jan Sundquist, Kristina Sundquist
BACKGROUND: We attempt to develop a relatively comprehensive structural model of risk factors for drug abuse (DA) in Swedish men that illustrates developmental and mediational processes. METHODS: We examined 20 risk factors for DA in 48,369 men undergoing conscription examinations in 1969-70 followed until 2011 when 2.34% (n=1134) of them had DA ascertained in medical, criminal and pharmacy registries. Risk factors were organized into four developmental tiers reflecting i) birth, ii) childhood/early adolescence, iii) late adolescence, and iv) young adulthood...
July 29, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28806629/aseptic-meningitis-in-adults-and-children-diagnostic-and-management-challenges
#20
Bhavarth Shukla, Elizabeth A Aguilera, Lucrecia Salazar, Susan H Wootton, Quanhathai Kaewpoowat, Rodrigo Hasbun
BACKGROUND: Aseptic meningitis represents a common diagnostic and management dilemma to clinicians. OBJECTIVES: To compare the clinical epidemiology, diagnostic evaluations, management, and outcomes between adults and children with aseptic meningitis. STUDY DESIGN: We conducted a retrospective study from January 2005 through September 2010 at 9 Memorial Hermann Hospitals in Houston, TX. Patients age≥2months who presented with community-acquired aseptic meningitis with a CSF white blood cell count >5cells/mm(3) and a negative Gram stain and cultures were enrolled...
August 4, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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