Elisabeth Kemter, Antonio Citro, Lelia Wolf-van Buerck, Yi Qiu, Anika Böttcher, Martina Policardi, Silvia Pellegrini, Libera Valla, Marianna Alunni-Fabbroni, Julianna Kobolák, Barbara Kessler, Mayuko Kurome, Valeri Zakhartchenko, Andras Dinnyes, Clemens C Cyran, Heiko Lickert, Lorenzo Piemonti, Jochen Seissler, Eckhard Wolf
BACKGROUND: Islet xenotransplantation is a promising concept for beta-cell replacement therapy. Reporter genes for noninvasive monitoring of islet engraftment, graft mass changes, long-term survival, and graft failure support the optimization of transplantation strategies. Near-infrared fluorescent protein (iRFP) is ideal for fluorescence imaging (FI) in tissue, but also for multispectral optoacoustic tomography (MSOT) with an even higher imaging depth. Therefore, we generated reporter pigs ubiquitously expressing iRFP...
January 2022: Xenotransplantation