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less invasive stabilisation system

Giulia Cancian, Gianluca Tozzi, Amirul Ashraf Bin Hussain, Arianna De Mori, Marta Roldo
Age related bone diseases such as osteoporosis are considered among the main causes of reduced bone mechanical stability and bone fractures. In order to restore both biological and mechanical function of diseased/fractured bones, novel bioactive scaffolds that mimic the bone structure are constantly under development in tissue engineering applications. Among the possible candidates, chitosan-based thermosensitive hydrogel scaffolds represent ideal systems due to their biocompatibility, biodegradability, enhanced antibacterial properties, promotion of osteoblast formation and ease of injection, which makes them suitable for less invasive surgical procedures...
August 2016: Journal of Materials Science. Materials in Medicine
Yun Fei Hou, Fang Zhou, Yun Tian, Hong Quan Ji, Zhi Shan Zhang, Yan Guo, Yang Lv
INTRODUCTION: Difficult removal of locking plates including less invasive stabilisation systems (LISSs) and locking compression plates (LCPs) sometimes occur. However, investigations of the mechanisms and correlated factors of complicated removal remain scant. This study aims to identify correlated factors for the difficult removal of locking plates and to propose suggestions for decision making regarding implant removal and the prevention of complicated removal. MATERIALS AND METHODS: In total, 308 consecutive patients who underwent LCP/LISS removal from Sep...
2015: Injury
D C Singleton, P Rouhi, C E Zois, S Haider, J-L Li, B M Kessler, Y Cao, A L Harris
Hypoxia is a common feature of locally advanced breast cancers that is associated with increased metastasis and poorer survival. Stabilisation of hypoxia-inducible factor-1α (HIF1α) in tumours causes transcriptional changes in numerous genes that function at distinct stages of the metastatic cascade. We demonstrate that expression of RIOK3 (RIght Open reading frame kinase 3) was increased during hypoxic exposure in an HIF1α-dependent manner. RIOK3 was localised to distinct cytoplasmic aggregates in normoxic cells and underwent redistribution to the leading edge of the cell in hypoxia with a corresponding change in the organisation of the actin cytoskeleton...
September 3, 2015: Oncogene
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