Po-Hsien Hsu, Prakash Kishore Hazam, Yi-Ping Huang, Jih-Chao Yeh, Yun-Ru Chen, Chao-Chin Li, Chi-Fon Chang, Je-Wen Liou, Jyh-Yih Chen
Antimicrobial peptides (AMPs) are natural molecules that function within the innate immune system to counteract pathogenic invasion and minimize the detrimental consequences of infection. However, utilizing these molecules for medical applications has been challenging. In this study, we selected a model AMP with poor stability, Tilapia Piscidin 4 (TP4), and modified its sequence and chirality (TP4-γ) to improve its potential for clinical application. The strategy of chirality inversion was inspired by the cereulide peptide, which has a DDLL enantiomer pattern and exhibits exceptional stability...
December 28, 2023: Biomedicine & Pharmacotherapy