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https://www.readbyqxmd.com/read/28612912/temporal-healing-patterns-and-coverage-dynamics-after-new-polish-transcatheter-pfo-occluder-implantation-in-a-swine
#1
Krzysztof Milewski, Roland Fiszer, Piotr Paweł Buszman, Przemysław Węglarz, Adam Janas, Agata Krauze, Michał Jelonek, Piotr Hirnle, Grzegorz Smolka, Robert Gil, Jacek Białkowski, Paweł Eugeniusz Buszman
BACKGROUND: Although currently used devices for interventional closure of patent foramen ovale (PFO) are widely used due to minimally invasive nature of this technique and high success rate, there is still a need to look for new materials and designs in order to improve the treatment outcomes. AIM: To evaluate safety, biocompatibility, temporal healing patterns and coverage dynamics of the new Polish PFO occluder (Balton, Warsaw, Poland) in a swine model - an observation that may assist decision with regard to its first-in-human use and duration of anticoagulation therapy...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28558023/structural-and-functional-dissection-reveals-distinct-roles-of-ca2-binding-sites-in-the-giant-adhesin-siie-of-salmonella-enterica
#2
Britta Peters, Johanna Stein, Stefan Klingl, Nathalie Sander, Achim Sandmann, Nicola Taccardi, Heinrich Sticht, Roman G Gerlach, Yves A Muller, Michael Hensel
The giant non-fimbrial adhesin SiiE of Salmonella enterica mediates the first contact to the apical site of epithelial cells and enables subsequent invasion. SiiE is a 595 kDa protein composed of 53 repetitive bacterial immunoglobulin (BIg) domains and the only known substrate of the SPI4-encoded type 1 secretion system (T1SS). The crystal structure of BIg50-52 of SiiE revealed two distinct Ca2+-binding sites per BIg domain formed by conserved aspartate or glutamate residues. In a mutational analysis Ca2+-binding sites were disrupted by aspartate to serine exchange at various positions in the BIg domains of SiiE...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28434124/comparative-outcome-of-pfna-gamma-nails-pccp-medoff-plate-liss-and-dynamic-hip-screws-for-fixation-in-elderly-trochanteric-fractures-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#3
Alisara Arirachakaran, Tanawat Amphansap, Pichaya Thanindratarn, Peerapong Piyapittayanun, Phutsapong Srisawat, Jatupon Kongtharvonskul
The ideal implant for the treatment of an unstable intertrochanteric femoral fracture is still a matter of discussion. The aim of this systematic review is to conduct a network meta-analysis of randomized controlled trials (RCTs) comparing clinical outcomes between dynamic hip screws (DHS), Medoff sliding plating, percutaneous compression plating (PCCP), proximal femoral nails (PFN), Gamma nails and less invasive stabilization system fixation in femoral trochanteric fractures in the elderly. These clinical outcomes consist of total intra-operative time, intra-operative fluoroscopy time, intra-operative blood loss, blood component transfusion, length of hospital stay, postoperative general complications, wound complications, late complications and reoperation rates...
April 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28427235/catan-ionic-hybrid-lipidic-nano-carriers-for-enhanced-bioavailability-and-anti-tumor-efficacy-of-chemodrugs
#4
Bilin Liu, Dan He, Jianyong Wu, Quan Sun, Mi Zhang, Qunyou Tan, Yao Li, Jingqing Zhang
To date there has not been any report on catan-ionic hybrid lipidic nano-carriers, let alone a report on applying them to deliver insoluble anti-tumor drugs. Catan-ionic hybrid lipidic nano-carriers containing curcumin (CUR-C-HLN) inherit the merits of catan-ionic systems, hybrid lipidic systems and nano-structured carriers (the second-generation substitute of solid lipidic nano-systems). Catan-ionic surfactants increased microvesicle stabilization by producing unordered isometric clusters, enhanced absorptive amount as an inhibitor of enzyme and protein, improved tumor accumulation by cellular endocytosis and membranous fusion; hybrid lipids helped to obtain high drug content and low leakage by forming a less-organized matrix arrangement...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28323096/nanoparticles-as-safe-and-effective-delivery-systems-of-antifungal-agents-achievements-and-challenges
#5
REVIEW
Ghareb M Soliman
Invasive fungal infections are becoming a major health concern in several groups of patients leading to severe morbidity and mortality. Moreover, cutaneous fungal infections are a major cause of visits to outpatient dermatology clinics. Despite the availability of several effective agents in the antifungal drug arena, their therapeutic outcome is less than optimal due to limitations related to drug physicochemical properties and toxicity. For instance, poor aqueous solubility limits the formulation options and efficacy of several azole antifungal drugs while toxicity limits the benefits of many other drugs...
March 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28243378/change-of-lumbar-ligamentum-flavum-after-indirect-decompression-using-anterior-lumbar-interbody-fusion
#6
Seiji Ohtori, Sumihisa Orita, Kazuyo Yamauchi, Yawara Eguchi, Yasuchika Aoki, Junichi Nakamura, Masayuki Miyagi, Miyako Suzuki, Gou Kubota, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hiroto Kanamoto, Gen Inoue, Kazuhisa Takahashi, Takeo Furuya, Masao Koda
STUDY DESIGN: Retrospective case series. PURPOSE: The purpose of this study was to examine changes in the ligamentum flavum thickness and remodeling of the spinal canal after anterior fusion during a 10-year follow-up. OVERVIEW OF LITERATURE: Extreme lateral interbody fusion provides minimally invasive treatment of the lumbar spine; this anterior fusion without direct posterior decompression, so-called indirect decompression, can achieve pain relief...
February 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28208979/evaluation-of-the-efficacy-of-bupivacaine-0-5-alone-or-with-clonidine-1%C3%AE-g-kg-versus-control-in-a-single-level-paravertebral-blockin-patients-undergoing-pcnl-procedure
#7
Trupti S Kamble, Charulata Mahesh Deshpande
INTRODUCTION: Percutaneous Nephrolithotomy (PCNL) is a widely used procedure to remove complex upper tract renal calculi by means of a nephroscope. Although less invasive, PCNL is associated with significant pain owing to soft tissue injury. Most of these patients have mild to moderately compromised renal function. An anaesthesia plan that reduces intraoperative requirement of anaesthetics, analgesics, muscle relaxants and postoperative requirement of systemic analgesics is essential...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28141644/midfacial-changes-through-anterior-maxillary-distraction-osteogenesis-in-patients-with-cleft-lip-and-palate
#8
Hiroyuki Kanzaki, Yoshimichi Imai, Tetsu Nakajo, Takayoshi Daimaruya, Akimitsu Sato, Masahiro Tachi, Youhei Nunomura, Yusuke Itagaki, Kazuaki Nishimura, Shoko Kochi, Kaoru Igarashi
Maxillary hypoplasia is a major issue in cleft lip and palate patients, and predictable surgical maxillary advancement is required. In the present study, the changes and stability of the maxilla and soft tissue profile achieved after the application of anterior maxillary distraction osteogenesis (AMDO) using intraoral expander in unilateral cleft lip and palate and isolated cleft palate patients were investigated by comparing to the Le Fort I osteotomy (LFI) and maxillary distraction osteogenesis (DO) with rigid external distraction (RED) system...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28092269/analysis-of-microtubule-growth-dynamics-arising-from-altered-actin-network-structure-and-contractility-in-breast-tumor-cells
#9
Eleanor C Ory, Lekhana Bhandary, Amanda E Boggs, Kristi R Chakrabarti, Joshua Parker, Wolfgang Losert, Stuart S Martin
The periphery of epithelial cells is shaped by opposing cytoskeletal physical forces generated predominately by two dynamic force generating systems-growing microtubule ends push against the boundary from the cell center, and the actin cortex contracts the attached plasma membrane. Here we investigate how changes to the structure and dynamics of the actin cortex alter the dynamics of microtubules. Current drugs target actin polymerization and contraction to reduce cell division and invasiveness; however, the impacts on microtubule dynamics remain incompletely understood...
April 20, 2017: Physical Biology
https://www.readbyqxmd.com/read/28028646/first-clinical-results-of-minimally-invasive-vector-lumbar-interbody-fusion-mis-vlif-in-spondylodiscitis-and-concomitant-osteoporosis-a-technical-note
#10
Bernhard Rieger, Hongzhen Jiang, Daniel Ruess, Clemens Reinshagen, Marek Molcanyi, Jozef Zivcak, Huaiyu Tong, Gabriele Schackert
PURPOSE: First description of MIS-VLIF, a minimally invasive lumbar stabilization, to evaluate its safety and feasibility in patients suffering from weak bony conditions (lumbar spondylodiscitis and/or osteoporosis). METHODS: After informed consent, 12 patients suffering from lumbar spondylodiscitis underwent single level MIS-VLIF. Eight of them had a manifest osteoporosis, either. Pre- and postoperative clinical status was documented using numeric rating scale (NRS) for leg and back pain...
December 27, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27983529/autoantibodies-against-heat-shock-proteins-as-biomarkers-for-the-diagnosis-and-prognosis-of-cancer
#11
REVIEW
Liu Shi, Yann Chevolot, Eliane Souteyrand, Emmanuelle Laurenceau
Thanks to their specificity and stability in the sera, autoantibodies (AAbs) against tumor-associated antigens (TAAs) are very attractive biomarkers for the development of less invasive serological tests for the diagnosis and prognosis of cancer. Heat shock proteins (HSP) belong to TAAs and they are over-expressed in various human cancers. Elevated HSP can stimulate the immune system to produce anti-HSP antibodies. So far, AAbs against HSP have been identified in the circulation of various cancer patients. Here we will review current literature on the use of anti-HSP antibodies for cancer diagnosis and prognosis...
2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27882313/experiences-in-tick-control-by-acaricide-in-the-traditional-cattle-sector-in-zambia-and-burkina-faso-possible-environmental-and-public-health-implications
#12
REVIEW
Daniele De Meneghi, Frédéric Stachurski, Hassane Adakal
Livestock, especially cattle, play a paramount role in agriculture production systems, particularly in poor countries throughout the world. Ticks and tick-borne diseases (TBDs) have an important impact on livestock and agriculture production in sub-Saharan Africa. The authors review the most common methods used for the control of ticks and TBDs. Special emphasis is given to the direct application of acaricides to the host animals. The possible environmental and public health adverse effects (i.e., risks for the workers, residues in the environment and in food products of animal origin) are mentioned...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27825874/ultra-miniaturization-of-a-planar-amperometric-sensor-targeting-continuous-intradermal-glucose-monitoring
#13
Federico Ribet, Göran Stemme, Niclas Roxhed
An ultra-miniaturized electrochemical biosensor for continuous glucose monitoring (CGM) is presented. The aim of this work is to demonstrate the possibility of an overall reduction in sensor size to allow minimally invasive glucose monitoring in the interstitial fluid in the dermal region, in contrast to larger state-of-the-art systems, which are necessarily placed in the subcutaneous layer. Moreover, the reduction in size might be a key factor to improve the stability and reliability of transdermal sensors, due to the reduction of the detrimental foreign body reaction and of consequent potential failures...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27716018/less-invasive-lumbopelvic-fixation-technique-using-a-percutaneous-pedicle-screw-system-for-unstable-pelvic-ring-fracture-in-a-patient-with-severe-multiple-traumas
#14
Sei Yano, Yasuchika Aoki, Atsuya Watanabe, Takayuki Nakajima, Makoto Takazawa, Hiroyuki Hirasawa, Kazuhisa Takahashi, Koichi Nakagawa, Arata Nakajima, Hiroshi Takahashi, Sumihisa Orita, Yawara Eguchi, Takane Suzuki, Seiji Ohtori
Pelvic ring fractures are defined as life-threatening injuries that can be treated surgically with external or internal fixation. The authors report on an 81-year-old woman with an unstable pelvic fracture accompanying multiple traumas that was successfully treated with a less invasive procedure. The patient was injured in a traffic accident and sustained a total of 20 fractures, including pelvic ring, bilateral rib, and lumbar transverse processes fractures, and multiple fractures of both upper and lower extremities...
February 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27609710/mandibular-distraction-osteogenesis-a-systematic-review-of-stability-and-the-effects-on-hard-and-soft-tissues
#15
REVIEW
G Rossini, B Vinci, R Rizzo, T M DaC Pinho, A Deregibus
Mandibular distraction osteogenesis (MDO) has been widely adopted in modern maxillofacial surgery due to its less invasive approach and the consistent aesthetic and functional improvements obtained. The aim of the present systematic review was to analyze the available evidence on the skeletal and soft tissue effects of MDO. The medical literature was searched to identify all peer-reviewed papers meeting the selection criteria for the final review process. A three-point grading system was used to rate the methodological quality of the selected papers...
November 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27511196/reverse-polyaxial-less-invasive-stabilization-systems-for-treatment-of-femoral-intertrochanteric-fractures-of-the-distal-femur
#16
Longxiang Shen, Xiaolin Li, Tao Wang, Congfeng Luo, Bingfang Zeng, Jian Ding
INTRODUCTION: The reverse less invasive stabilization system (LISS) for the distal femur remains generally regarded as a safe and satisfactory option for the treatment of unstable proximal femoral fractures. The polyaxial LISS provides a reverse plating technique that leverages the advantages of proximal screws by allowing the adjustable locking screw to be better positioned and providing more reliable fixation on the proximal femur compared with the standard axial LISS. To assess this fixation method, a detailed evaluation of institutional outcomes of femoral intertrochanteric fractures treated with reverse polyaxial LISS was performed...
November 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27459337/above-vs-belowground-plant-biomass-along-a-barrier-island-implications-for-dune-stabilization
#17
Bianca R Charbonneau, John P Wnek, J Adam Langley, Gina Lee, Ronald A Balsamo
Coastal regions are inherently and increasingly vulnerable and geomorphologically unstable, yet are invaluable economic and residential hubs. Dunes are dynamic buffers to erosion and the most natural, economical, and effective defense for coastal communities. Vegetation is integral to dune structure as it facilitates accretion and stabilization. Differences in the vegetation and root density likely translate to variability in coastal erosion prevention, but this notion has been largely unconsidered. We directly compared stabilizing factors, depth and density, of the root systems of two dominant mid-Atlantic dune plant species, native American beach grass (Ammophila breviligulata) and invasive Asiatic sand sedge (Carex kobomugi)...
November 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27449592/augmentative-locking-plate-with-autologous-bone-grafting-for-distal-femoral-nonunion-subsequent-to-failed-retrograde-intramedullary-nailing
#18
COMPARATIVE STUDY
Jiang-Ying Ru, Yu Cong, Dai Shi, Yang-Hu Lu, Yun-Fei Niu, Hai-Dong Xu
OBJECTIVE: To explore the indications and efficacy of augmentative locking compression plate (LCP) or less invasive stabilization system (LISS)with autogenous bone grafting (BG) in treating distal femoral nonunion subsequent to failed retrograde intramedullary nailing (RIN). METHODS: A retrospective study was performed for 21 patients with distal femoral nonunion subsequent to failed RIN, who received therapy with either augmentative LCP (n = 11) or LISS with autogenous BG (n = 13)...
August 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27446925/personalized-medicine-in-cerebrovascular-neurosurgery-precision-neurosurgical-management-of-cerebral-aneurysms-and-subarachnoid-hemorrhage
#19
REVIEW
Achal Singh Achrol, Gary K Steinberg
Cerebral aneurysms are common vascular lesions. Little is known about the pathogenesis of these lesions and the process by which they destabilize and progress to rupture. Treatment decisions are motivated by a desire to prevent rupture and the devastating morbidity and mortality associated with resulting subarachnoid hemorrhage (SAH). For patients presenting with SAH, urgent intervention is required to stabilize the lesion and prevent re-rupture. Those patients fortunate enough to survive a presenting SAH and subsequent securing of their aneurysm must still face a spectrum of secondary sequelae, which can include cerebral vasospasm, delayed ischemia, seizures, cerebral edema, hydrocephalus, and endocrinologic and catecholamine-induced systemic dysfunction in cardiac, pulmonary, and renal systems...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27435361/the-outcome-of-unstable-proximal-femoral-fracture-treated-with-reverse-liss-plates
#20
Shih-Jie Lin, Kuo-Chin Huang, Po-Yao Chuang, Chien-Yin Lee, Tsan-Wen Huang, Mel S Lee, Robert Wen-Wei Hsu
BACKGROUND: The Russel-Taylor type 2B fractures compromised the trochanteric region and medial buttress of proximal femur. This fracture pattern limits the choice of implants and raises the risk of adverse outcomes. We aimed to (i) determine the outcome of Russel-Taylor type 2B fractures treated using reverse less invasive stabilization system plates (LISS-DF) and to (ii) learn what factors affected outcomes after osteosynthesis with reverse LISS plates. DESIGN: A retrospective study SETTING: The study was conducted at a Level III trauma center in Taiwan...
October 2016: Injury
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