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distal femoral fracture

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https://www.readbyqxmd.com/read/28208958/radiological-and-histopathological-outcome-of-giant-cell-tumor-of-femur-with-denosumab-treatment-a-case-report
#1
Preethi Dileep Menon, R Krishnakumar, Annie Jojo
Giant Cell Tumour of Bone (GCTB) is a benign but locally aggressive osteolytic skeletal neoplasm of young adults consisting of giant cells expressing RANK (Receptor Activator of Nuclear Factor-κB) and mesenchymal spindle-like stromal cells expressing RANKL (RANK ligand). The interaction of these cells leads to bone resorption. Recently, the RANKL inhibitor, denosumab, has demonstrated activity against giant-cell tumours. The current article reports a case of a Giant cell tumour of left distal femur with pathological fracture...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28204811/isopsoralen-mediated-suppression-of-bone-marrow-adiposity-and-attenuation-of-the-adipogenic-commitment-of-bone-marrow-derived-mesenchymal-stem-cells
#2
Jian Wang, Sheng-Fa Li, Ting Wang, Chun-Han Sun, Liang Wang, Min-Jun Huang, Jian Chen, Shao-Wei Zheng, Nan Wang, Ying-Jun Zhang, Tian-Yu Chen
Osteoporosis (OP) increases the risk of bone fractures and other complications, and is thus a major clinical problem. In this study, we examined the effect of isopsoralen on the differentiation of bone-derived marrow mesenchymal stem cells (BMSCs) into osteoblasts and adipocytes, as well as bone formation under osteoporotic conditions. Primary femoral BMSCs isolated from C57BL/6 mice were used to evaluate the isopsoralen-mediated regulation of the expression of alkaline phosphatase (ALP), osteocalcin (OCN) and runt-related transcription factor 2 (RUNX2) during osteogenesis 2 weeks...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28186871/augmentation-of-proximal-femoral-nail-in-unstable-trochanteric-fractures
#3
Wasudeo M Gadegone, Bhaskaran Shivashankar, Vijayanad Lokhande, Yogesh Salphale
INTRODUCTION: Biomechanically proximal femoral nail (PFN) is a better choice of implant, still it is associated with screw breakage, cut out of screw through femoral head, Z effect, reverse Z effect, and lateral migration of screws. The purpose of this study is to evaluate the results of augmented PFN in terms of prevention of postoperative complications and failure rates in unstable trochanteric fractures. MATERIAL AND METHODS: We carried out a prospective study of 82 cases with unstable trochanteric femoral fractures from April 2010 to December 2015...
2017: SICOT-J
https://www.readbyqxmd.com/read/28181695/later-age-at-onset-of-independent-walking-is-associated-with-lower-bone-strength-at-fracture-prone-sites-in-older-men
#4
Alex Ireland, Stella Muthuri, Joern Rittweger, Judith E Adams, Kate A Ward, Diana Kuh, Rachel Cooper
Later age at onset of independent walking is associated with lower leg bone strength in childhood and adolescence. However it is unknown whether these associations persist into older age, or whether they are evident at axial (central) or upper limb sites. Therefore we examined walking age obtained at 2y and bone outcomes obtained by dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) scans at 60-64y in a nationally-representative cohort study of British people, the MRC National Survey of Health and Development...
February 9, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28178228/imaging-evaluation-of-the-safe-region-for-distal-locking-screw-of-proximal-femoral-nail-anti-rotation-in-patients-with-proximal-femoral-fracture
#5
Jinpeng Gong, Pengcheng Liu, Ming Cai
BACKGROUND Proximal femoral nail anti-rotation (PFNA) is a standard femoral intertrochanteric fracture operation. Iatrogenic vascular injury, although uncommon, is a reported complication of PFNA surgery as well as a complication of hip fracture surgery. This study aimed to compare the safety and best use of the distal locking screw in 170 mm PFNA and 240 mm PFNA devices, and to determine the safe region for placement of the distal locking screw in PFNA surgery. MATERIAL AND METHODS A retrospective analysis of 100 patients with 170 mm PFNA and 80 patients with 240 mm PFNA were retrospectively analyzed...
February 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28169937/outcomes-of-distal-femur-nonunions-treated-with-a-combined-nail-plate-construct-and-autogenous-bone-grafting
#6
Basem Attum, Diana Douleh, Paul S Whiting, Gabrielle A White-Dzuro, Ashley C Dodd, Michelle S Shen, William T Obremskey, Manish K Sethi
SummaryIn this study, we sought to retrospectively evaluate union and infection rates after treatment of distal femur nonunions using a combined nail/plate construct with autogenous bone grafting. 10 patients treated at a Level I Trauma Center for nonunion of a femoral fracture using a combined nail/plate construct from 2004 to 2014 were included in the study. Union rate and postoperative infection rate were recorded.10 patients underwent treatment for nonunion of the distal femur. Mean interval from index surgery to nonunion repair was 12 months (range 4-36 months)...
December 26, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28166168/evaluation-of-intra-articular-fracture-extension-following-gunshot-wounds-to-the-lower-extremity-plain-radiographs-versus-computer-tomography
#7
John S Hwang, Kenneth L Koury, George Gorgy, Michael S Sirkin, Mark C Reilly, Valdis Lelkes, Mark R Adams
OBJECTIVE: This study was to compare the use of computer tomography to plain radiographs for the evaluation of intra-articular extension of long bone fractures in the lower extremity following low-energy gunshot wounds. DESIGN: Retrospective chart and radiographic review SETTING:: Level 1 Trauma CenterPatients/Participants: Data was collected from a single institution from 2000 to 2014. Inclusion criteria consisted of patients aged greater than 17 years, low-velocity gunshot injuries causing fracture of the femur or tibia, plain radiographs with adequate films and CT imaging of the fracture...
January 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28164053/long-term-bisphosphonate-therapy-induced-periprosthetic-femoral-stress-fracture-in-a-sliding-hip-screw-implant-a-unique-case-report
#8
Mark R Adams, Conor Dunn, Michael S Sirkin, Mark C Reilly
INTRODUCTION: Long-term bisphosphonate therapy for osteoporosis is associated with an increased risk of low-to-no energy atypical subtrochanteric and femoral shaft fractures with characteristic radiologic findings. There are few reports of patients with long-term bisphosphonate-induced periprosthetic fractures, all of them had a hip arthroplasty prosthesis. In this report, we present a unique case of a 90-year-old Caucasian female on long-term bisphosphonate therapy with a sliding hip screw implant who sustained a periprosthetic fracture of the femoral shaft at the distal aspect of the plate...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28153480/radiographic-predictors-of-symptomatic-screw-removal-after-retrograde-femoral-nail-insertion
#9
Max Hamaker, Nathan N O'Hara, W Andrew Eglseder, Marcus F Sciadini, Jason W Nascone, Robert V O'Toole
INTRODUCTION: Removal of symptomatic implants is a common procedure performed by orthopaedic trauma surgeons. No guidance is available regarding which factors contribute to the likelihood of an implant becoming symptomatic. Our objective was to determine whether radiographic parameters associated with distal interlocks in retrograde femoral nails are associated with the rate of symptomatic screw removal. PATIENTS AND METHODS: We conducted a retrospective review at a Level I trauma center...
January 6, 2017: Injury
https://www.readbyqxmd.com/read/28145569/modified-thomas-splint-cast-combination-for-the-management-of-limb-fractures-in-small-equids
#10
Søren Ladefoged, Sigrid Grulke, Valeria Busoni, Didier Serteyn, Alexandra Salciccia, Denis Verwilghen
OBJECTIVE: To describe the management and outcome of limb fractures in small domestic equids treated with a modified Thomas splint-cast combination (MTSCC). STUDY DESIGN: Retrospective case series. ANIMALS: Client owned horses and donkeys. METHODS: Medical records, including radiographs, were reviewed for details of animals diagnosed with a limb fracture and treated by external coaptation using a MTSCC (2001-2012). Follow-up >6 months after discharge was obtained via telephone consultation with owners or veterinarians...
February 1, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28131543/predictors-of-functional-recovery-following-periprosthetic-distal-femur-fractures
#11
John A Ruder, Gavin P Hart, Jeffrey S Kneisl, Bryan D Springer, Madhav A Karunakar
BACKGROUND: Treatment options for periprosthetic distal femur fractures include open reduction internal fixation (ORIF) and distal femoral replacement (DFR). The purpose of this study was to evaluate the complications, and functional recovery (ambulatory status, living situation, mortality) in patients undergoing operative treatment (DFR and ORIF) of periprosthetic distal femur fractures. METHODS: A retrospective review of 58 patients with distal femoral periprosthetic fractures treated with either ORIF or DFR was conducted...
December 23, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28116256/a-technical-note-for-extracting-an-incarcerated-femoral-kuntscher-nail
#12
Marí R, Valverde Vilamala D, León García A, Guirro P, Marqués López F
INTRODUCTION: The use of the Kuntscher nail has been the most important advancement in trauma surgery. One of the problems is the difficulty to remove it. A new extraction technique is described in the present case report. CASE REPORT: A 46-year-old man was referred for hip osteoarthritis. He had an acetabulum fracture and a femoral shaft fracture treated 30 years ago with a reamed Kuntscher femoral nail. Lateral hip approach was performed and after attempting to remove the nail with the specific tools being unsuccessful we decided to be more aggressive...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28115800/a-3%C3%A2-year-minimum-follow-up-of-endoprosthetic-replacement-for-distal-femoral-fractures-an-alternative-treatment-option
#13
A Atrey, N Hussain, O Gosling, P Giannoudis, A Shepherd, S Young, J Waite
INTRODUCTION: Although the use of an endoprosthesis for distal femoral fractures remains a valid treatment option the widespread use is in its infancy. METHODOLOGY: In this retrospective case series, we review cases of distal femoral fracture treated with endoprosthetic replacement (EPR). The outcomes we assessed were the time to start mobilising, the time to discharge, morbidity and mortality as well as an Oxford knee score to assess pain and function and also the early survivorship...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28108173/broach-handle-design-changes-force-distribution-in-the-femur-during-total-hip-arthroplasty
#14
Dustin A Greenhill, Pooyan Abbasi, Kurosh Darvish, Andrew M Star
BACKGROUND: Curved broach handles were developed to overcome limited surgical exposures during total hip arthroplasty. Some authors report increased intraoperative fracture rates during limited exposures. This study evaluates mechanical force ratios transmitted to the bone while broaching with curved vs straight handles. METHODS: An experimental model utilized a 6-axis load cell to measure force distributions produced by 4 different broach handles, each with increasing offset and curvature...
December 29, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28097725/increased-cortical-porosity-in-women-with-hip-fracture
#15
D Sundh, A G Nilsson, M Nilsson, L Johansson, D Mellström, M Lorentzon
BACKGROUND: Hip fractures cause increased mortality and disability and consume enormous healthcare resources. Only 46% of hip fracture patients have osteoporosis at the total hip according to dual-energy X-ray absorptiometry (DXA) measurement. Cortical porosity increases with ageing and is believed to be important for bone strength. OBJECTIVE: To investigate whether older women with hip fracture have higher cortical porosity than controls, and if so whether this difference is independent of clinical risk factors and areal bone mineral density (aBMD)...
January 18, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28093609/periprosthetic-fracture-around-a-stable-femoral-stem-treated-with-locking-plate-osteosynthesis-distal-femoral-locking-plate-alone-versus-with-cerclage-cable
#16
Young-Soo Shin, Seung-Beom Han
To promote rapid bone healing, an adequate stable fixation implant with a percutaneous reduction instrument should be used for Vancouver type B1 or C fractures. The objective of this study was to describe radiographic and clinical outcomes of patients with periprosthetic fracture (PPF) around a stable femoral stem, treated with a distal femoral locking plate alone or with a cerclage cable. A total of 21 patients with PPF amenable to either a reverse distal femoral locking plate (LCP DF(®)) alone or with a cerclage cable, with a mean age of 75...
January 16, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28093251/malalignment-after-minimally-invasive-plate-osteosynthesis-in-distal-femoral-fractures
#17
Joon-Woo Kim, Chang-Wug Oh, Jong-Keon Oh, Il-Hyung Park, Hee-Soo Kyung, Kyeong-Hyeon Park, Seong-Dae Yoon, Seong-Min Kim
INTRODUCTION: Although minimally invasive plate osteosynthesis (MIPO) is a preferred operative treatment for fractures of the distal femur, malalignment is a significant concern because of indirect reduction of the fracture. The purpose of this study, therefore, was to evaluate radiologic alignment after MIPO for distal femoral fractures. PATIENTS AND METHODS: Of the 138 patients with fracture of the distal femur who underwent MIPO, we enrolled 51 patients in whom bilateral rotational alignment could be assessed by postoperative computed tomography (CT)...
January 10, 2017: Injury
https://www.readbyqxmd.com/read/28088942/a-distal-lock-electromagnetic-targeting-device-for-intramedullary-nailing-suggestions-and-clinical-experience
#18
Guido Antonini, Wilfried Stuflesser, Cornelio Crippa, Georgios Touloupakis
PURPOSE: To describe our clinical experience with a system named SureShot? Distal Targeting (Smith & Nephew, Memphis, USA) based on magnetic field presence and discuss our suggestions on this technique. METHODS: We analysed prospectively 47 patients affected by humeral, tibial or femoral fractures, treated in our institution during a 3-year period of time (August 2010 to September 2013). We considered the following parameters: the time to set up, the time to position a single screw, the effectiveness of the system (drilling ad screwing), the irradiation exposure time during distal locking procedure and surgical complications...
December 1, 2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28088646/bone-microarchitecture-in-adolescent-boys-with-autism-spectrum-disorder
#19
Ann M Neumeyer, Natalia Cano Sokoloff, Erin McDonnell, Eric A Macklin, Christopher J McDougle, Madhusmita Misra
BACKGROUND: Boys with autism spectrum disorder (ASD) have lower areal bone mineral density (aBMD) than typically developing controls (TDC). Studies of volumetric BMD (vBMD) and bone microarchitecture provide information about fracture risk beyond that provided by aBMD but are currently lacking in ASD. OBJECTIVES: To assess ultradistal radius and distal tibia vBMD, bone microarchitecture and strength estimates in adolescent boys with ASD compared to TDC. DESIGN/METHODS: Cross-sectional study of 34 boys (16 ASD, 18 TDC) that assessed (i) aBMD at the whole body (WB), WB less head (WBLH), hip and spine using dual X-ray absorptiometry (DXA), (ii) vBMD and bone microarchitecture at the ultradistal radius and distal tibia using high-resolution peripheral quantitative CT (HRpQCT), and (iii) bone strength estimates (stiffness and failure load) using micro-finite element analysis (FEA)...
January 11, 2017: Bone
https://www.readbyqxmd.com/read/28087211/the-effect-of-bone-growth-onto-massive-prostheses-collars-in-protecting-the-implant-from-fracture
#20
Paul Fromme, Gordon W Blunn, William J Aston, Tasneem Abdoola, Jacob Koris, Melanie J Coathup
Limb-sparing distal femoral endoprotheses used in cancer patients have a high risk of aseptic loosening. It had been reported that young adolescent patients have a higher rate of loosening and fatigue fracture of intramedullary stems because the implant becomes undersized as patients grow. Extracortical bone growth into the grooved hydroxyapatite-coated collar had been shown to reduce failure rates. The stresses in the implant and femur have been calculated from Finite Element models for different stages of bone growth onto the collar...
January 10, 2017: Medical Engineering & Physics
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