keyword
https://read.qxmd.com/read/38430258/mots-c-regulates-pancreatic-alpha-and-beta-cell-functions-in-vitro
#21
JOURNAL ARTICLE
Jakub Bień, Ewa Pruszyńska-Oszmałek, Paweł Kołodziejski, Natalia Leciejewska, Dawid Szczepankiewicz, Maciej Sassek
The aim of this study is to determine the influence of the mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c) peptide on pancreatic cell physiology. Moreover, in this study, we examined the changes in MOTS-c secretion and expression under different conditions. Our experiments were conducted using laboratory cell line cultures, specifically the INS-1E and αTC-1 cell lines, which represent β and α pancreatic cells, respectively. As the pancreas is an endocrine organ, we also tested its hormone regulation capabilities...
March 2, 2024: Histochemistry and Cell Biology
https://read.qxmd.com/read/38429959/cystic-fibrosis-and-fat-malabsorption-pathophysiology-of-the-cystic-fibrosis-gastrointestinal-tract-and-the-impact-of-highly-effective-cftr-modulator-therapy
#22
REVIEW
Catherine M McDonald, Elizabeth K Reid, John F Pohl, Tatiana K Yuzyuk, Laura M Padula, Kay Vavrina, Kimberly Altman
Cystic fibrosis (CF) is a progressive, genetic, multi-organ disease affecting the respiratory, digestive, endocrine, and reproductive systems. CF can affect any aspect of the gastrointestinal (GI) tract, including the esophagus, stomach, small intestine, colon, pancreas, liver, and gall bladder. GI pathophysiology associated with CF results from CF membrane conductance regulator (CFTR) dysfunction. The majority of people with CF (pwCF) experience exocrine pancreatic insufficiency resulting in malabsorption of nutrients and malnutrition...
April 2024: Nutrition in Clinical Practice
https://read.qxmd.com/read/38422917/serotonin-transporter-imaging-agent-as-a-probe-for-%C3%AE-cells-of-pancreas
#23
JOURNAL ARTICLE
Yuli Sun, Guangwen Li, Haiyan Hong, Lin Zhu, Hank F Kung, Yan Zhang, Jinxia Zhu
OBJECTIVE: Diabetes mellitus (DM) is one of the major diseases in the world. Nuclear medicine imaging may be able to detect functional status of pancreatic β cells in vivo, which might elucidate the pathological mechanisms of diabetes and develop individualized treatment plans. In this study, we evaluated the ability of [125 I]ADAM, a serotonin transporter (SERT) imaging agent, as a probe for detecting pancreatic β-cell mass (BCM). METHODS: In vitro cell studies were evaluated in INS-1 cells (rat islet β cell line)...
February 24, 2024: Nuclear Medicine and Biology
https://read.qxmd.com/read/38414914/a-review-of-new-concepts-in-iron-overload
#24
JOURNAL ARTICLE
Aalam Sohal, Kris V Kowdley
Iron overload disorders are conditions that can lead to increased body iron stores and end-organ damage in affected organs. Increased iron deposition most commonly occurs in the liver, heart, endocrine system, joints, and pancreas. Iron overload disorders may be caused by genetic or acquired causes (transfusion, dyserythropoiesis, and chronic liver disease). The HFE gene C282Y homozygous mutation is the most common cause of hereditary hemochromatosis (HH). Other genes implicated in HH include TFR2 , HAMP, HJV, and SLC40A1 ...
February 2024: Gastroenterology & Hepatology
https://read.qxmd.com/read/38414818/differential-effects-of-fish-oil-and-cocoa-butter-based-high-fat-high-sucrose-diets-on-endocrine-pancreas-morphology-and-function-in-mice
#25
JOURNAL ARTICLE
Shaima Albeloushi, Amal Hasan, Hossein Arefanian, Sardar Sindhu, Fatema Al-Rashed, Shihab Kochumon, Nermeen Abukhalaf, Texy Jacob, Steve Shenouda, Ashraf Al Madhoun, Fahd Al-Mulla, Rasheed Ahmad
INTRODUCTION: A high-fat/high-sucrose diet leads to adverse metabolic changes that affect insulin sensitivity, function, and secretion. The source of fat in the diet might inhibit or increase this adverse effect. Fish oil and cocoa butter are a significant part of our diets. Yet comparisons of these commonly used fat sources with high sucrose on pancreas morphology and function are not made. This study investigated the comparative effects of a fish oil-based high-fat/high-sucrose diet (Fish-HFDS) versus a cocoa butter-based high-fat/high-sucrose diet (Cocoa-HFDS) on endocrine pancreas morphology and function in mice...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38413286/the-clinical-and-biochemical-spectrum-of-ectopic-acromegaly
#26
REVIEW
Patricia Fainstein-Day, Tamara Estefanía Ullmann, Mercedes Corina Liliana Dalurzo, Gustavo Emilio Sevlever, David Eduardo Smith
Ectopic acromegaly is a rare condition caused by extrapituitary central or peripheral neuroendocrine tumours (NET) that hypersecrete GH or, more commonly, GHRH. It affects less than 1% of acromegaly patients and a misdiagnosis of classic acromegaly can lead to an inappropriate pituitary surgery. Four types of ectopic acromegaly have been described: 1) Central ectopic GH-secretion: Careful cross-sectional imaging is required to exclude ectopic pituitary adenomas. 2) Peripheral GH secretion: Extremely rare. 3) Central ectopic GHRH secretion: Sellar gangliocytomas immunohistochemically positive for GHRH are found after pituitary surgery...
February 14, 2024: Best Practice & Research. Clinical Endocrinology & Metabolism
https://read.qxmd.com/read/38412155/evidence-for-dopamine-production-and-distribution-of-dopamine-d2-receptors-in-the-equine-gastrointestinal-mucosa-and-pancreas
#27
JOURNAL ARTICLE
Nicolas C Galinelli, Nicholas J Bamford, Melody A de Laat, Martin N Sillence, Patricia A Harris, Simon R Bailey
Insulin dysregulation in horses is characterised by hyperinsulinaemia and/or tissue insulin resistance and is associated with increased risk of laminitis. There is growing evidence in other species that dopamine attenuates insulin release from the pancreas; however, this has yet to be examined in horses. The present study aimed to identify whether there are cells capable of producing or responding to dopamine within the equine gastrointestinal mucosa and pancreas. Tissue samples were collected from the stomach, small and large intestines, and pancreas of six mature horses following euthanasia...
2024: PloS One
https://read.qxmd.com/read/38398492/interactions-between-the-exocrine-and-the-endocrine-pancreas
#28
REVIEW
Roberto Valente, Alessandro Coppola, Chiara Maria Scandavini, Asif Halimi, Annelie Magnusson, Augusto Lauro, Ira Sotirova, Urban Arnelo, Oskar Franklin
The pancreas has two main functions: to produce and secrete digestive enzymes (exocrine function) and to produce hormones that regulate blood glucose and splanchnic secretion (endocrine function). The endocrine and exocrine portions of the pancreas are central regulators in digestion and metabolism, with continuous crosstalk between their deeply interconnected components, which plays a role in disease. Pancreatic neoplasms, inflammation, trauma, and surgery can lead to the development of type 3c diabetes when an insult simultaneously damages both acini and islets, leading to exocrine and endocrine dysfunction...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38397919/glucometabolism-in-kidney-transplant-recipients-with-and-without-posttransplant-diabetes-focus-on-beta-cell-function
#29
JOURNAL ARTICLE
Amelie Kurnikowski, Benedetta Salvatori, Michael Krebs, Klemens Budde, Kathrin Eller, Julio Pascual, Micaela Morettini, Christian Göbl, Manfred Hecking, Andrea Tura
Posttransplant diabetes mellitus (PTDM) is a common complication after kidney transplantation. Pathophysiologically, whether beta-cell dysfunction rather than insulin resistance may be the predominant defect in PTDM has been a matter of debate. The aim of the present analysis was to compare glucometabolism in kidney transplant recipients with and without PTDM. To this aim, we included 191 patients from a randomized controlled trial who underwent oral glucose tolerance tests (OGTTs) 6 months after transplantation...
January 30, 2024: Biomedicines
https://read.qxmd.com/read/38396558/metabolic-and-endocrine-insights-in-donkeys
#30
REVIEW
Francisco J Mendoza, Ramiro E Toribio, Alejandro Perez-Ecija
Donkey medicine is gaining attention due to their increased use as companion animals, in shows, asinotherapy, etc. The increasing demand and unique aspects call for specialized care, requiring new information (physiology, infectious disorders, pharmacology, etc.). Since obesity is common in this species, hyperlipemia, metabolic syndrome and insulin dysregulation (ID) are common disorders in donkeys, in some cases with high mortality, either directly (multiorgan dysfunction) or indirectly due to poor quality of life (chronic laminitis)...
February 10, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38389307/role-of-cftr-in-diabetes-induced-pancreatic-ductal-fluid-and-hco-3-secretion
#31
JOURNAL ARTICLE
Attila Ébert, Eleonóra Gál, Emese Tóth, Titanilla Szögi, Péter Hegyi, Viktória Venglovecz
Type 1 diabetes is a disease of the endocrine pancreas; however, it also affects exocrine function. Although most studies have examined the effects of diabetes on acinar cells, much less is known regarding ductal cells, despite their important protective function in the pancreas. Therefore, we investigated the effect of diabetes on ductal function. Diabetes was induced in wild-type and cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice following an i.p. administration of streptozotocin...
February 22, 2024: Journal of Physiology
https://read.qxmd.com/read/38388766/mechanism-exploration-and-biomarker-identification-of-glycemic-deterioration-in-patients-with-diseases-of-the-exocrine-pancreas
#32
JOURNAL ARTICLE
Zhen Wang, Guolin Zhang, Jixian Fu, Guangxing Li, Zhihao Zhao, HyokChol Choe, Kaiyue Ding, Junnan Ma, Jing Wei, Dong Shang, Lin Zhang
The damage to the endocrine pancreas among patients with diseases of the exocrine pancreas (DP) leads to reduced glycemic deterioration, ultimately resulting in diabetes of the exocrine pancreas (DEP). The present research aims to investigate the mechanism responsible for glycemic deterioration in DP patients, and to identify useful biomarkers, with the ultimate goal of enhancing clinical practice awareness. Gene expression profiles of patients with DP in this study were acquired from the Gene Expression Omnibus database...
February 22, 2024: Scientific Reports
https://read.qxmd.com/read/38379865/editorial-footprints-of-immune-cells-in-the-type-1-diabetic-pancreas-volume-ii
#33
EDITORIAL
Gustaf Christoffersson, Georgia Fousteri
No abstract text is available yet for this article.
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38379586/intrapancreatic-fat-deposition-is-unrelated-to-liver-steatosis-in-metabolic-dysfunction-associated-steatotic-liver-disease
#34
JOURNAL ARTICLE
Anne Linde Mak, Nienke Wassenaar, Anne-Marieke van Dijk, Marian Troelstra, Veera Houttu, Koen van Son, Stan Driessen, Diona Zwirs, Sandra van den Berg-Faay, Elizabeth Shumbayawonda, Jurgen Runge, Michail Doukas, Joanne Verheij, Ulrich Beuers, Max Nieuwdorp, Djuna L Cahen, Aart Nederveen, Oliver Gurney-Champion, Adriaan Holleboom
BACKGROUND & AIMS: Individuals with obesity may develop intrapancreatic fat deposition (IPFD) and fatty pancreas disease (FPD). Whether this causes inflammation and fibrosis and leads to pancreatic dysfunction is less established than for liver damage in metabolic dysfunction-associated steatotic liver disease (MASLD). Moreover, the interrelations of FPD and MASLD are poorly understood. Therefore, we aimed to assess IPFD and fibro-inflammation in relation to pancreatic function and liver disease severity in individuals with MASLD...
March 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38377787/the-significance-of-glutaredoxins-for-diabetes-mellitus-and-its-complications
#35
REVIEW
Mengmeng Zhou, Eva-Maria Hanschmann, Axel Römer, Thomas Linn, Sebastian Friedrich Petry
Diabetes mellitus is a non-communicable metabolic disease hallmarked by chronic hyperglycemia caused by beta-cell failure. Diabetic complications affect the vasculature and result in macro- and microangiopathies, which account for a significantly increased morbidity and mortality. The rising incidence and prevalence of diabetes is a major global health burden. There are no feasible strategies for beta-cell preservation available in daily clinical practice. Therefore, patients rely on antidiabetic drugs or the application of exogenous insulin...
January 20, 2024: Redox Biology
https://read.qxmd.com/read/38373589/the-pancreas-does-not-contribute-to-the-non-adrenergic-non-cholinergic-stimulation-of-heart-rate-in-digesting-pythons
#36
JOURNAL ARTICLE
Igor Noll Guagnoni, Katja B Last, Emil Rindom, Tobias Wang
Vertebrates elevate heart rate when metabolism increases during digestion. Part of this tachycardia is due to a non-adrenergic-non-cholinergic (NANC) stimulation of the cardiac pacemaker, and it has been suggested these NANC factors are circulating hormones that are released from either gastrointestinal or endocrine glands. The NANC stimulation is particularly pronounced in species with large metabolic responses to digestion, such as reptiles. To investigate the possibility that the pancreas may release hormones that exert positive chronotropic effects on the digesting Burmese python heart, a species with very large postprandial changes in heart rate and oxygen uptake, we evaluate how pancreatectomy affects postprandial heart rate before and after autonomic blockade of the muscarinic and the beta-adrenergic receptors...
February 17, 2024: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://read.qxmd.com/read/38371595/editorial-advances-in-veterinary-endocrine-oncology
#37
EDITORIAL
Floryne O Buishand, Sara Galac
No abstract text is available yet for this article.
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38368592/the-impact-of-apelin-13-on-cisplatin-induced-endocrine-pancreas-damage-in-rats-an-in-vivo-study
#38
JOURNAL ARTICLE
Serpil Ciftel, Levent Tumkaya, Sinan Saral, Tolga Mercantepe, Kerimali Akyildiz, Adnan Yilmaz, Filiz Mercantepe
Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas are of interest. This study aims to investigate the potential protective effects of apelin-13 in cisplatin-induced endocrine pancreatic damage. Twenty-four rats were divided into four groups: control, apelin-13, cisplatin, and cisplatin + apelin-13. Caspase-3, TUNEL, and Ki-67 immunohistochemical staining were used as markers of apoptosis and mitosis. NF-κB/p65 and TNFα were used to show inflammation...
February 18, 2024: Histochemistry and Cell Biology
https://read.qxmd.com/read/38367680/assessment-of-anti-hyperglycemic-and-anti-hyperlipidemic-effects-of-thiazolidine-2-4-dione-derivatives-in-hfd-stz-diabetic-animal-model
#39
JOURNAL ARTICLE
Saad Fettach, Fatima Zahra Thari, Khalid Karrouchi, Laila Benbacer, Learn-Han Lee, Abdelhakim Bouyahya, Yahia Cherrah, Hassan Sefrioui, Khalid Bougrin, My El Abbes Faouzy
Type 2 diabetes mellitus (T2DM) is a chronic endocrine/metabolic disorder characterized by elevated postprandial and fasting glycemic levels that result in disturbances in primary metabolism. In this study, we evaluated the metabolic effects of thiazolidine-2,4-dione derivatives in Wistar rats and Swiss mice that were fed a high-fat diet (HFD) for 4 weeks and received 90 mg/kg of streptozotocin (STZ) intraperitoneally as a T2DM model. The HFD consisted of 17% carbohydrate, 58% fat, and 25% protein, as a percentage of total kcal...
February 15, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38363191/point-shear-wave-elastography-generated-by-acoustic-radiation-force-impulse-in-chronic-pancreatitis
#40
JOURNAL ARTICLE
Maximilian Wekerle, Katharina Murillo, Manuel vonBoscamp, Veronika Hauber, Matthias P Ebert, Christoph Antoni, Michael Hirth
BACKGROUND: Transcutaneous point-shear wave elastography (p-SWE) performed using an acoustic radiation force impulse can be used to quantify pancreatic stiffness in chronic pancreatitis (CP). We aimed to evaluate its usefulness to diagnose and monitor CP. METHODS: 175 participants were included in this prospective study including patients with CP (n = 65), liver cirrhosis (LC; n = 60), alcohol abuse (n = 10) and healthy controls (n = 40)...
February 16, 2024: United European Gastroenterology Journal
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