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https://www.readbyqxmd.com/read/29020582/cd55-deficiency-and-protein-losing-enteropathy
#1
LETTER
Alina Kurolap, Orly Eshach-Adiv, Hagit N Baris
New England Journal of Medicine, Volume 377, Issue 15, Page 1499-1500, October 2017.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29020581/cd55-deficiency-and-protein-losing-enteropathy
#2
LETTER
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28977405/genome-scale-detection-of-positive-selection-in-nine-primates-predicts-human-virus-evolutionary-conflicts
#3
Robin van der Lee, Laurens Wiel, Teunis J P van Dam, Martijn A Huynen
Hotspots of rapid genome evolution hold clues about human adaptation. We present a comparative analysis of nine whole-genome sequenced primates to identify high-confidence targets of positive selection. We find strong statistical evidence for positive selection in 331 protein-coding genes (3%), pinpointing 934 adaptively evolving codons (0.014%). Our new procedure is stringent and reveals substantial artefacts (20% of initial predictions) that have inflated previous estimates. The final 331 positively selected genes (PSG) are strongly enriched for innate and adaptive immunity, secreted and cell membrane proteins (e...
August 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28963754/diminished-presentation-of-complement-regulatory-protein-cd55-on-red-blood-cells-from-patients-with-hereditary-haemolytic-anaemias
#4
A Loniewska-Lwowska, K Koza, E Mendek-Czajkowska, P Wieszczy, A Adamowicz-Salach, K Branicka, I Witos, A Sapala-Smoczynska, T Jackowska, J Fabijanska-Mitek
INTRODUCTION: Hereditary haemolytic anaemias (HHA) encompass a heterogeneous group of anaemias characterized by decreased red blood cell survival. The aim of this study was to evaluate the status of red blood cell (RBC) surface molecules known or previously proposed to participate in preventing premature RBC clearance, analysing erythrocytes from patients with two types of HHA: hereditary spherocytosis (HS) and microcytosis. MATERIAL/METHODS: Relative binding of five monoclonal antibodies (mAbs), anti-CD55, anti-CD59, anti-CD44, anti-CD47 and anti-CD58, was evaluated in erythrocytes of patients with HS and hereditary microcytosis, using flow cytometry...
September 30, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28957817/altered-expression-pattern-of-cd55-and-cd59-on-red-blood-cells-in-anemia-of-chronic-kidney-disease
#5
Lama Al Faris, Salah Al-Humood, Fatma Behbehani, Husam Sallam
OBJECTIVE: To investigate the expression pattern of CD55 and CD59 on red blood cells (RBCs) in anemic chronic kidney disease (CKD) patients, and factors that might infleunce their expression. SUBJECTS AND METHODS: Nighty one adult anemic CKD patients and 80 healthy controls (HC) were enrolled. Anemic CKD patients were divided into 3 subgroups based on receiving erythropoietin (EPO) and renal replacement therapies (RRT). Flow cytometric analysis of CD55 and CD59 expression was performed on RBCs from blood samples obtained from CKD patients and HC...
September 28, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28944962/hpv-e6-protein-enriches-the-cd55-population-in-cervical-cancer-cells-promoting-radio-resistance-and-cancer-aggressiveness
#6
Thomas Ho-Yin Leung, Hermit Wai-Man Tang, Michelle Kwan-Yee Siu, David Wai Chan, Karen Kar-Loen Chan, Annie Nga-Yin Cheung, Hextan Yuen-Sheung Ngan
Accumulating evidence indicates that the human papilloma virus (HPV) E6 protein plays a crucial role in the development of cervical cancer. Sub-populations of cells that reside within tumors are responsible for tumor resistance to cancer therapy and recurrence. However, the identity of such cells residing in cervical cancer and their relationship with the HPV-E6 protein have not been identified. Here, we isolated sphere-forming cells, which exhibited self-renewal ability, from primary cervical tumors. Gene expression profiling revealed that CD55 was upregulated in primary cervical cancer sphere cells...
September 25, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28943429/shear-stress-mediated-changes-in-the-expression-of-complement-regulatory-protein-cd59-on-human-endothelial-progenitor-cells-by-ecm-integrin%C3%AE-v%C3%AE-3-f-actin-pathway-in-vitro
#7
Xiaodong Cui, Xiaoyun Zhang, Hongnan Bu, Na Liu, Hong Li, Xiumei Guan, Hong Yan, Yuzhen Wang, Hua Zhang, Yuzhen Ding, Min Cheng
Membrane regulatory proteins, such as CD46, CD55, and CD59, prevent excess complement activation and to protect cells from damage. Previous investigations confirmed that shear stress in the physiological range was more favorable for endothelial progenitor cells (EPCs) to repair injured vascular endothelial cells and operates mainly in atheroprotective actions. However, detailed events that contribute to shear stress-induced protection in EPCs, particularly the mechanisms of signal transduction, remain poorly understood...
September 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28940198/complement-regulatory-proteins-in-kidneys-of-patients-with-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis
#8
Lu Cheng, Shen-Ju Gou, Hong-Yu Qiu, Liang Ma, Ping Fu
The complement system activation is involved in the development of ANCA-associated vasculitis (AAV). The study aimed to investigate the expression of complement regulatory proteins (CRPs) CD46, CD55, and CD59 in kidneys of 51 AVV patients. The expression of CD46, CD55 and CD59 in kidneys was detected by immunohistochemistry and double immunofluorescence staining. The immunohistochemical examination revealed that expression of the three CRPs could be detected in the glomeruli and tubules of both AAV patients and normal controls...
September 23, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28928834/cd55-and-cd59-expression-protects-her2-overexpressing-breast-cancer-cells-from-trastuzumab-induced-complement-dependent-cytotoxicity
#9
Yu Wang, Ya-Jun Yang, Zhu Wang, Juan Liao, Mei Liu, Xiao-Rong Zhong, Hong Zheng, Yan-Ping Wang
A large proportion (40-60%) of patients with human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer do not benefit from trastuzumab treatment, potentially due to the lack of complement-dependent cytotoxicity (CDC) activation. In the present study, the effect of complement decay-accelerating factor (CD55) and CD59 glycoprotein precursor (CD59) expression on trastuzumab-induced CDC in HER2-positive breast cancer cell lines was investigated. The CD55 and CD59-overexpressing and HER2-positive cell lines SK-BR-3 and BT474 were selected for subsequent experiments...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28895865/long-term-culture-and-differentiation-of-porcine-red-bone-marrow-hematopoietic-cells-co-cultured-with-immortalized-mesenchymal-cells
#10
Abubakar Garba, Delphine D Acar, Inge D M Roukaerts, Lowiese M B Desmarets, Bert Devriendt, Hans J Nauwynck
Mesenchymal cells are multipotent stromal cells with self-renewal, differentiation and immunomodulatory capabilities. We aimed to develop a co-culture model for differentiating hematopoietic cells on top of immortalized mesenchymal cells for studying interactions between hematopoietic and mesenchymal cells, useful for adequately exploring the therapeutic potential of mesenchymal cells. In this study, we investigated the survival, proliferation and differentiation of porcine red bone marrow hematopoietic cells co-cultured with immortalized porcine bone marrow mesenchymal cells for a period of five weeks...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28886871/daf-in-diabetic-patients-is-subject-to-glycation-inactivation-at-its-active-site-residues
#11
Rudolf Flückiger, Enzo Cocuzzi, Ram H Nagaraj, Menachem Shoham, Timothy S Kern, M Edward Medof
Decay accelerating factor (DAF or CD55) is a cell associated C3 and C5 convertase regulator originally described in terms of protection of self-cells from systemic complement but now known to modulate adaptive T cell responses. It is expressed on all cell types. We investigated whether nonenzymatic glycation could impair its function and potentially be relevant to complications of diabetes mellitus and other conditions that result in nonenzymatic glycation including cancer, Alzheimer's disease, and aging. Immunoblots of affinity-purified DAF from erythrocytes of patients with diabetes showed pentosidine, glyoxal-AGEs, carboxymethyllysine, and argpyrimidine...
September 5, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28838952/cd55-regulates-self-renewal-and-cisplatin-resistance-in-endometrioid-tumors
#12
Caner Saygin, Andrew Wiechert, Vinay S Rao, Ravi Alluri, Elizabeth Connor, Praveena S Thiagarajan, James S Hale, Yan Li, Anastasia Chumakova, Awad Jarrar, Yvonne Parker, Daniel J Lindner, Anil Belur Nagaraj, J Julie Kim, Analisa DiFeo, Fadi W Abdul-Karim, Chad Michener, Peter G Rose, Robert DeBernardo, Haider Mahdi, Keith R McCrae, Feng Lin, Justin D Lathia, Ofer Reizes
Effective targeting of cancer stem cells (CSCs) requires neutralization of self-renewal and chemoresistance, but these phenotypes are often regulated by distinct molecular mechanisms. Here we report the ability to target both of these phenotypes via CD55, an intrinsic cell surface complement inhibitor, which was identified in a comparative analysis between CSCs and non-CSCs in endometrioid cancer models. In this context, CD55 functions in a complement-independent manner and required lipid raft localization for CSC maintenance and cisplatin resistance...
September 4, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28793332/stromal-cell-markers-are-differentially-expressed-in-the-synovial-tissue-of-patients-with-early-arthritis
#13
Ivy Y Choi, Olga N Karpus, Jason D Turner, Debbie Hardie, Jennifer L Marshall, Maria J H de Hair, Karen I Maijer, Paul P Tak, Karim Raza, Jörg Hamann, Christopher D Buckley, Danielle M Gerlag, Andrew Filer
INTRODUCTION: Previous studies have shown increased expression of stromal markers in synovial tissue (ST) of patients with established rheumatoid arthritis (RA). Here, ST expression of stromal markers in early arthritis in relationship to diagnosis and prognostic outcome was studied. METHODS: ST from 56 patients included in two different early arthritis cohorts and 7 non-inflammatory controls was analysed using immunofluorescence to detect stromal markers CD55, CD248, fibroblast activation protein (FAP) and podoplanin...
2017: PloS One
https://www.readbyqxmd.com/read/28775208/a-multikinase-and-dna-pk-inhibitor-combination-immunomodulates-melanomas-suppresses-tumor-progression-and-enhances-immunotherapies
#14
Alexander K Tsai, Asra Y Khan, Christina E Worgo, Lucy L Wang, Yuanyuan Liang, Eduardo Davila
Combination therapies have the potential to improve outcomes in melanoma patients but have not yet been clinically efficacious. Here, we used high-throughput flow cytometry-based screening to identify and characterize candidate therapies that might synergize with and augment T-cell immunotherapy efficacy. Two lead therapies, regorafenib (Reg) and NU7441, were selected based on their ability to alter a variety of immunomodulatory proteins, including CD55, CD73, CD155, programmed death-ligand 1 (PD-L1), nerve growth factor receptor (NGFR), and HLA class I in a heterogeneous panel of melanomas...
September 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28761231/renal-manifestations-in-paroxysmal-nocturnal-hemoglobinuria
#15
R Ram, K P Adiraju, S Gudithi, K V Dakshinamurty
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic disorder characterized by a triad of clinical features - hemolytic anemia, pancytopenia, and thrombosis. Not many reports of renal involvement in PNH are available in literature. We present a case series of PNH with renal involvement. We present the data of PNH patients who attended to Departments of General Medicine and Nephrology at a government-run tertiary care institute in South India. The diagnosis of PNH in these patients during initial phase, between 1998 and 2004 was based on sucrose lysis and Ham's test...
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28761230/renal-biopsy-in-paroxysmal-nocturnal-hemoglobinuria-an-insight-into-the-spectrum-of-morphologic-changes
#16
V Puri, A Gandhi, S Sharma
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, potentially life-threatening disease of blood, characterized by complement-induced intravascular hemolytic anemia and thrombosis. PNH can sometimes present directly with renal manifestations, without showing any hematological manifestation. It, therefore, becomes essential for clinicians and pathologists to be aware of the spectrum of renal changes in PNH. The aim of this study was to document the morphologic changes observed in renal biopsies in patients with PNH...
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28718265/haemoglobinuria-and-portal-venous-thrombosis-in-a-young-male
#17
Zain Ul Abideen, Munnam Sohail Jafar, Nasir Hameed, Ahmad Malik
Paroxysmal nocturnal haemoglobinuria is a non-malignant stem cell disorder due to acquired somatic mutations in cell surface anchored proteins CD55 and CD59. Both have a compliment inhibitory role and their deficiency leads to intravascular haemolysis. This paper reports a challenging case of a 25 years old male who presented with generalized weakness, exertional dyspnoea and episodic early morning haematuria. Recently, he started developing progressive abdominal distention and dull generalized abdominal pain...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28680334/expression-of-cd55-cd59-and-cd35-on-red-blood-cells-of-%C3%AE-thalassaemia-patients
#18
Ayşegül Uǧur Kurtoǧllu, Belkls Koçtekin, Erdal Kurtoǧlu, Mustafa Yildiz, Selen Bozkurt
AIM OF THE STUDY: β-thalassaemia (β-Thal) is considered a severe, progressive haemolytic anaemia, which needs regular blood transfusions for life expectancy. Complement-mediated erythrocyte destruction can cause both intravascular and extravascular haemolysis. Complement regulatory proteins protect cells from such effects of the complement system. We aimed to perform quantitative analysis of membrane-bound complement regulators, CD55 (decay accelerating factor - DAF), CD35 (complement receptor type 1 - CR1), and CD59 (membrane attack complex inhibitory factor - MACIF) on peripheral red blood cells by flow cytometry...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28657861/loss-of-cd55-in-eculizumab-responsive-protein-losing-enteropathy
#19
LETTER
Alina Kurolap, Orly Eshach-Adiv, Tova Hershkovitz, Tamar Paperna, Adi Mory, Danit Oz-Levi, Yaniv Zohar, Hanna Mandel, Judith Chezar, David Azoulay, Sarit Peleg, Elizabeth E Half, Vered Yahalom, Lilach Finkel, Omer Weissbrod, Dan Geiger, Adi Tabib, Ron Shaoul, Daniella Magen, Lilach Bonstein, Dror Mevorach, Hagit N Baris
New England Journal of Medicine, Volume 377, Issue 1, Page 87-89, July 2017.
July 6, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28657829/cd55-deficiency-early-onset-protein-losing-enteropathy-and-thrombosis
#20
Ahmet Ozen, William A Comrie, Rico C Ardy, Cecilia Domínguez Conde, Buket Dalgic, Ömer F Beser, Aaron R Morawski, Elif Karakoc-Aydiner, Engin Tutar, Safa Baris, Figen Ozcay, Nina K Serwas, Yu Zhang, Helen F Matthews, Stefania Pittaluga, Les R Folio, Aysel Unlusoy Aksu, Joshua J McElwee, Ana Krolo, Ayca Kiykim, Zeren Baris, Meltem Gulsan, Ismail Ogulur, Scott B Snapper, Roderick H J Houwen, Helen L Leavis, Deniz Ertem, Renate Kain, Sinan Sari, Tülay Erkan, Helen C Su, Kaan Boztug, Michael J Lenardo
BACKGROUND: Studies of monogenic gastrointestinal diseases have revealed molecular pathways critical to gut homeostasis and enabled the development of targeted therapies. METHODS: We studied 11 patients with abdominal pain and diarrhea caused by early-onset protein-losing enteropathy with primary intestinal lymphangiectasia, edema due to hypoproteinemia, malabsorption, and less frequently, bowel inflammation, recurrent infections, and angiopathic thromboembolic disease; the disorder followed an autosomal recessive pattern of inheritance...
July 6, 2017: New England Journal of Medicine
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