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tachycardia-mediated cardiomyopathy

Monika Gawor, Mateusz Śpiewak, Jadwiga Janas, Katarzyna Kożuch, Aleksandra Wróbel, Łukasz Mazurkiewicz, Rafał Baranowski, Magdalena Marczak, Jacek Grzybowski
BACKGROUND: Estimation of sudden cardiac death (SCD) risk is an integral part of clinical management of patients with hypertrophic cardiomyopathy (HCM). Identification of novel biomarkers of this disease can provide additional criteria for SCD risk stratification. Soluble suppression of tumorigenicity (sST2) and galectin-3 (Gal-3) are useful biomarkers for prognosis of heart failure (HF). Both of them appear to mediate cardiac fibrosis - an important pathogenetic process in HCM. Data about sST2 and Gal-3 usefulness in patients with HCM are limited...
June 14, 2017: Kardiologia Polska
Andrew P Landstrom, Dobromir Dobrev, Xander H T Wehrens
There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca(2+)) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes, including catecholaminergic polymorphic ventricular tachycardia, congenital long QT syndrome, and hypertrophic cardiomyopathy. In addition, acquired deficits of multiple Ca(2+)-handling proteins can contribute to the pathogenesis of arrhythmias in patients with various types of heart disease...
June 9, 2017: Circulation Research
Hailei Liu, Chao Zhu, Bing Yang, Weizhu Ju, Hongwu Chen, Fengxiang Zhang, Kai Gu, Mingfang Li, Pipin Kojodjojo, Minglong Chen
INTRODUCTION: Detailed description of longstanding persistent accelerated idioatrial rhythm (AIAR) is lacking. This observational study investigated the clinical manifestations, electrophysiological characteristics, diagnosis, treatment and prognosis of this unusual arrhythmia. METHODS AND RESULTS: Fifteen patients (11 males; average age 25.9±15.7 years) suspected with longstanding persistent AIAR were enrolled in our study. All patients had ECG, 24-hour Holter monitoring, isoproterenol provocation test, echocardiogram, and exercise treadmill test...
May 9, 2017: Journal of Cardiovascular Electrophysiology
Naqash J Sethi, Sanam Safi, Joshua Feinberg, Emil E Nielsen, Christian Gluud, Janus C Jakobsen
BACKGROUND: Atrial fibrillation is the most common arrhythmia of the heart with a prevalence of approximately 2% in the western world. Atrial flutter, another arrhythmia, occurs less often with an incidence of approximately 200,000 new patients per year in the USA. Patients with atrial fibrillation and atrial flutter have an increased risk of death and morbidities. In the management of atrial fibrillation and atrial flutter, it is often necessary to use medical interventions to lower the heart rate...
April 5, 2017: Systematic Reviews
O V Blagova, A V Nedostup, E A Kogan, V A Sulimov, S A Abugov, A G Kupriyanova, V A Zaydenov, A E Donnikov, E V Zaklyazminskaya, E A Okisheva
BACKGROUND: The nosological nature of "idiopathic" arrhythmias and the effect of etiotropic and pathogenetic treatment are often unknown. METHODS AND RESULTS: 19 patients (42.6±11.3 years, 9 women) with atrial fibrillation (n = 16), supraventricular (n = 10) and ventricular (n = 4) premature beats, supraventricular (n = 2) and ventricular tachycardia (n = 1), left bundle branch block (n= 2), AV block (n = 2) without structural heart changes. Viruses were identified (polymerase chain reaction, PCR) along with measurement of anti-heart antibodies (AHA) and endomyocardial biopsy (EMB)...
June 2016: Journal of Atrial Fibrillation
Saamir A Hassan, Syed Wamique Yusuf, Jyoti Sharma, Jasmine Khan, Michele Guindani, Vicente Valero, Mariana Chavez-McGregor, Jose Banchs
OBJECTIVES: To identify unique echocardiographic features that could be used to reliably predict LVEF recovery upon resolution of sinus tachycardia in patients with cancer. BACKGROUND: Sinus tachycardia may be a manifestation of underlying cardiomyopathy or can lead to a reversible form of dilated cardiomyopathy known as tachycardia-mediated cardiomyopathy. While distinguishing the two can be challenging, predicting recovery regardless of cause can be of significant clinical importance in the cancer population...
January 2017: Echocardiography
David K Singh, Nitish Badhwar
This article reports a typical case of incessant double-fire tachycardia resulting in implantable cardioverter-defibrillator discharge caused by the device's misdiagnosis of ventricular tachycardia. At electrophysiology study, the presence of double-fire physiology was confirmed, and modification of the slow pathway resulted in elimination of repetitive double fires. Although this is an unusual entity, it is important to recognize, because it may be misdiagnosed as atrial fibrillation, resulting in inappropriate anticoagulation and/or antiarrhythmic therapy...
March 2016: Cardiac Electrophysiology Clinics
Michael B Stokes, Pankaj Saxena, Justin A Mariani, David M Kaye, Peter Bergin, David C McGiffin
A case is described of cardiogenic shock that occurred following use of sotalol in a patient with severe left ventricular dysfunction. The patient required left ventricular assist device (LVAD) placement with subsequent myocardial recovery to a degree that allowed eventual device removal following 140 days of support.
November 2015: Journal of Cardiac Surgery
Bruce B Lerman
Idiopathic ventricular arrhythmia is a generic term for a spectrum of arrhythmias that occur in the absence of structural heart disease or ion channelopathy. These arrhythmias include monomorphic premature ventricular contractions (PVCs), nonsustained monomorphic ventricular tachycardia (VT), and sustained VT. Most idiopathic ventricular arrhythmias originate from the right and left ventricular outflow tracts and include sites accessed from the aortic sinuses of Valsalva. Outflow tract arrhythmia is identified by an electrocardiographic pattern consistent with a left bundle branch block inferior axis morphology...
October 2015: Nature Reviews. Cardiology
Eric N Prystowsky, Benzy J Padanilam, Richard I Fogel
IMPORTANCE: Atrial fibrillation is a common arrhythmia that affects more than 2.5 million people in the United States and causes substantial morbidity and mortality, especially regarding the increased risk of stroke. OBJECTIVE: To summarize atrial fibrillation treatment exclusive of stroke prevention. EVIDENCE REVIEW: An Ovid MEDLINE comprehensive literature search was performed on atrial fibrillation therapy excluding anticoagulation and emphasizing studies published within the last 5 years through April 2015 (N = 5044 references)...
July 21, 2015: JAMA: the Journal of the American Medical Association
Béatrice Brembilla-Perrot, Maxime Bénichou, Alice Brembilla, Erwan Bozec, Sarah Dorlet, Jean Marc Sellal, Arnaud Olivier, Vladimir Manenti, Thibaut Villemin, Daniel Beurrier, Anne Moulin-Zinsch, Christian De Chillou, Nicolas Girerd
OBJECTIVES: To jointly study paroxysmal supraventricular tachycardia (SVT)-related adverse events (AE) and ablation-related complications, with specific emphasis on the predictors of SVT-related AE as well as their significance by investigating their association with long-term mortality. METHODS: 1770 patients were included, aged 6 to 97, with either atrioventricular nodal reentrant tachycardia (AVNRT) or orthodromic atrioventricular reciprocal tachycardia (AVRT) mediated by concealed accessory pathway, consecutively referred for SVT work-up in a tertiary care center...
November 15, 2015: International Journal of Cardiology
Srikanth Vallurupalli, Naga Venkata K Pothineni, Abhishek Deshmukh, Hakan Paydak
Class Ic antiarrhythmic agents are effective in the treatment of various atrial tachyarrhythmias. They are known to cause rate-related QRS widening in the presence of structural heart disease, which can lead to life-threatening arrhythmias. The role of routine exercise electrocardiography in patients without structural heart disease is unknown. All patients initiated on class Ic antiarrhythmic agents and who had exercise electrocardiography performed from June 2009 to June 2013 were included. Symptom-limited treadmill electrocardiography was performed to detect significant QRS widening at peak exercise (defined as an increase of >25% of baseline QRS)...
September 1, 2015: American Journal of Cardiology
Kathleen Hayes Brown, Richard G Trohman, Christopher Madias
Acute emotional or physical stress can trigger a catecholamine-mediated myocardial stunning known as takotstubo cardiomyopathy (TCM). Although TCM is generally reversible, it can be associated with significant morbidity, including secondarily to cardiac arrhythmia. Lethal arrhythmias such as heart block, ventricular tachycardia, and ventricular fibrillation have been described. Repolarization abnormalities associated with TCM can lead to characteristic T-wave abnormalities and QT prolongation that place patients at increased risk for ventricular arrhythmia, including torsades de pointes...
June 2015: Cardiac Electrophysiology Clinics
Chris Healy, Juan F Viles-Gonzalez, Luis C Sáenz, Mariana Soto, Juan D Ramírez, Andre d'Avila
Chagas disease, a chronic parasitosis caused by the protozoa Trypanosoma cruzi, is an increasing worldwide problem because of the number of cases in endemic areas and the migration of infected individuals to more developed regions. Chagas disease affects the heart through cardiac parasympathetic neuronal depopulation, immune-mediated myocardial injury, parasite persistence in cardiac tissue with secondary antigenic stimulation, and coronary microvascular abnormalities causing myocardial ischemia. A lack of knowledge exists for risk stratification, management, and prevention of ventricular arrhythmias in patients with chagasic cardiomyopathy...
June 2015: Cardiac Electrophysiology Clinics
Binu Philips, Anneline S J M te Riele, Abhishek Sawant, Vishnupriya Kareddy, Cynthia A James, Brittney Murray, Crystal Tichnell, Bina Kassamali, Saman Nazarian, Daniel P Judge, Hugh Calkins, Harikrishna Tandri
BACKGROUND: Variable success rates have been reported after epicardial radiofrequency catheter ablation (RFA) in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). The details of the electroanatomic substrate are limited to a few studies, and the characteristics of the recurrent ventricular tachycardia (VT) in ARVD/C remain largely unknown. OBJECTIVE: The purpose of this study was to report procedural strategy, safety, and efficacy of epicardial RFA at a tertiary single center with a focus on the characteristics of the substrate and recurrent VT...
April 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Saurabh Kumar, Chirag Barbhaiya, Koichi Nagashima, Eue-Keun Choi, Laurence M Epstein, Roy M John, Melanie Maytin, Christine M Albert, Amy L Miller, Bruce A Koplan, Gregory F Michaud, Usha B Tedrow, William G Stevenson
BACKGROUND: Cardiac sarcoid-related ventricular tachycardia (VT) is a rare disorder; the underlying substrate and response to ablation are poorly understood. We sought to examine the ventricular substrate and outcomes of catheter ablation in this population. METHODS AND RESULTS: Of 435 patients with nonischemic cardiomyopathy referred for VT ablation, 21 patients (5%) had cardiac sarcoidosis. Multiple inducible VTs were observed with mechanism consistent with scar-mediated re-entry in all VTs...
February 2015: Circulation. Arrhythmia and Electrophysiology
Hernando Vargas-Uricoechea, Anilsa Bonelo-Perdomo, Carlos Hernán Sierra-Torres
Thyroid hormones have a significant impact on heart function, mediated by genomic and non-genomic effects. Consequently, thyroid hormone deficiencies, as well as excesses, are expected to result in profound changes in cardiac function regulation and cardiovascular hemodynamics. Thyroid hormones upregulate the expression of the sarcoplasmic reticulum calcium-activated ATPase and downregulate the expression of phospholamban. Overall, hyperthyroidism is characterized by an increase in resting heart rate, blood volume, stroke volume, myocardial contractility, and ejection fraction...
November 2014: Clínica e Investigación en Arteriosclerosis
Jim W Cheung, James E Ip, Ravi K Yarlagadda, Christopher F Liu, George Thomas, Linna Xu, David Wilkes, Steven M Markowitz, Bruce B Lerman
BACKGROUND: A hallmark of idiopathic right ventricular outflow tract (RVOT) tachycardia is its sensitivity to adenosine (ADO), which is consistent with a triggered mechanism. We have identified a novel group of patients with ADO-insensitive, non-reentrant RVOT tachycardia. OBJECTIVE: This study aimed to identify the clinical and electrophysiologic characteristics of ADO-insensitive RVOT tachycardia. METHODS: The response of ventricular tachycardia (VT) to ADO was evaluated in 46 consecutive patients with inducible sustained idiopathic RVOT tachycardia...
October 2014: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Tania Zaglia, Giulia Milan, Aaron Ruhs, Mauro Franzoso, Enrico Bertaggia, Nicola Pianca, Andrea Carpi, Pierluigi Carullo, Paola Pesce, David Sacerdoti, Cristiano Sarais, Daniele Catalucci, Marcus Krüger, Marco Mongillo, Marco Sandri
Cardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome system and is fundamental for cardiac adaptation to both physiologic (e.g., exercise) and pathologic (e.g., pressure overload) stresses. Both the UPS and autophagy/lysosome system exhibit reduced efficiency as a consequence of aging, and dysfunction in these systems is associated with cardiomyopathies. The muscle-specific ubiquitin ligase atrogin-1 targets signaling proteins involved in cardiac hypertrophy for degradation...
June 2014: Journal of Clinical Investigation
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