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https://www.readbyqxmd.com/read/28238284/native-t1-mapping-inter-study-inter-observer-and-inter-center-reproducibility-in-hemodialysis-patients
#1
Matthew P M Graham-Brown, Elaine Rutherford, E Levelt, Daniel S March, Darren R Churchward, David J Stensel, Christie McComb, Kenneth Mangion, Samantha Cockburn, Colin Berry, James C Moon, Patrick B Mark, James O Burton, Gerry P McCann
BACKGROUND: Native T1 mapping is a cardiovascular magnetic resonance (CMR) technique that associates with markers of fibrosis and strain in hemodialysis patients. The reproducibility of T1 mapping in hemodialysis patients, prone to changes in fluid status, is unknown. Accurate quantification of myocardial fibrosis in this population has prognostic potential. METHODS: Using 3 Tesla CMR, we report the results of 1) the inter-study, inter-observer and intra-observer reproducibility of native T1 mapping in 10 hemodialysis patients; 2) inter-study reproducibility of left ventricular (LV) structure and function in 10 hemodialysis patients; 3) the agreement of native T1 map and native T1 phantom analyses between two centres in 20 hemodialysis patients; 4) the effect of changes in markers of fluid status on native T1 values in 10 hemodialysis patients...
February 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28238233/cardiac-fibrosis-in-aortic-stenosis-and-hypertensive-heart-disease-assessed-by-magnetic-resonance-t1-mapping
#2
Florian von Knobelsdorff-Brenkenhoff, Anna-Katharina Mueller, Marcel Prothmann, Pierre Hennig, Matthias A Dieringer, Luisa Schmacht, Andreas Greiser, Jeanette Schulz-Menger
BACKGROUND: Continuous pressure overload may lead to subclinical myocardial tissue changes in patients with hypertensive heart disease (HHD) and aortic stenosis (AS). The study aim was to detect interstitial fibrosis using quantitative cardiovascular magnetic resonance. METHODS: Fifteen patients with HHD (arterial hypertension + septal wall thickness ≥13 mm), 33 with AS (eight mild, 15 moderate, 10 severe), and 60 healthy controls were enrolled. Native T1 maps (modified Look-Locker inversion recovery) were obtained in a basal, mid-ventricular, and apical shortaxis slice of the left ventricle to assess cardiac fibrosis...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28237298/assessment-of-liver-fibrosis-using-t1-mapping-on-gd-eob-dtpa-enhanced-magnetic-resonance
#3
Ruo Fan Sheng, He Qing Wang, Li Yang, Kai Pu Jin, Yan Hong Xie, Cai Xia Fu, Meng Su Zeng
BACKGROUND: Few studies have investigated the value of Gd-EOB-DTPA-enhanced T1 mapping in exact fibrosis staging, especially its correlation with hepatic molecular transporters. AIMS: To investigate the diagnostic value of Gd-EOB-DTPA-enhanced T1 mapping in staging liver fibrosis and its relationship with hepatic molecular transporters. METHODS: Thirty rats were divided into the carbon tetrachloride-induced fibrosis groups and a control group...
February 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28215181/effect-of-cellular-and-extracellular-pathology-assessed-by-t1-mapping-on-regional-contractile-function-in-hypertrophic-cardiomyopathy
#4
Peter P Swoboda, Adam K McDiarmid, Bara Erhayiem, Graham R Law, Pankaj Garg, David A Broadbent, David P Ripley, Tarique A Musa, Laura E Dobson, James R Foley, Graham J Fent, Stephen P Page, John P Greenwood, Sven Plein
BACKGROUND: Regional contractile dysfunction is a frequent finding in hypertrophic cardiomyopathy (HCM). We aimed to investigate the contribution of different tissue characteristics in HCM to regional contractile dysfunction. METHODS: We prospectively recruited 50 patients with HCM who underwent cardiovascular magnetic resonance (CMR) studies at 3.0 T including cine imaging, T1 mapping and late gadolinium enhancement (LGE) imaging. For each segment of the American Heart Association model segment thickness, native T1, extracellular volume (ECV), presence of LGE and regional strain (by feature tracking and tissue tagging) were assessed...
February 20, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28213448/detection-and-monitoring-of-acute-myocarditis-applying-quantitative-cardiovascular-magnetic-resonance
#5
Florian von Knobelsdorff-Brenkenhoff, Johannes Schüler, Serkan Dogangüzel, Matthias A Dieringer, Andre Rudolph, Andreas Greiser, Peter Kellman, Jeanette Schulz-Menger
BACKGROUND: Cardiovascular magnetic resonance based on the Lake Louise Criteria is used to make the diagnosis of acute myocarditis. Novel quantitative parametric mapping techniques promise to overcome some of its limitations. We aimed to evaluate quantitative cardiovascular magnetic resonance to detect and monitor acute myocarditis. METHODS AND RESULTS: Eighteen patients with clinical diagnosis of acute myocarditis (25 years [23-38 years]; 78% males) were prospectively enrolled and repeatedly underwent cardiovascular magnetic resonance at 1...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28207845/reproducibility-and-comparison-of-oxygen-enhanced-t1-quantification-in-copd-and-asthma-patients
#6
Simon M F Triphan, Bertram J Jobst, Angela Anjorin, Oliver Sedlaczek, Ursula Wolf, Maxim Terekhov, Christian Hoffmann, Sebastian Ley, Christoph Düber, Jürgen Biederer, Hans-Ulrich Kauczor, Peter M Jakob, Mark O Wielpütz
T1 maps have been shown to yield useful diagnostic information on lung function in patients with chronic obstructive pulmonary disease (COPD) and asthma, both for native T1 and ΔT1, the relative reduction while breathing pure oxygen. As parameter quantification is particularly interesting for longitudinal studies, the purpose of this work was both to examine the reproducibility of lung T1 mapping and to compare T1 found in COPD and asthma patients using IRSnapShotFLASH embedded in a full MRI protocol. 12 asthma and 12 COPD patients (site 1) and further 15 COPD patients (site 2) were examined on two consecutive days...
2017: PloS One
https://www.readbyqxmd.com/read/28199043/diagnostic-performance-of-t1-and-t2-mapping-to-detect-intramyocardial-hemorrhage-in-reperfused-st-segment-elevation-myocardial-infarction-stemi-patients
#7
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Esther Gonzalez-Lopez, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna S Herrey, Charlotte Manisty, Derek M Yellon, James C Moon, Derek J Hausenloy
PURPOSE: To investigate the performance of T1 and T2 mapping to detect intramyocardial hemorrhage (IMH) in ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI). MATERIALS AND METHODS: Fifty STEMI patients were prospectively recruited between August 2013 and July 2014 following informed consent. Forty-eight patients completed a 1.5T cardiac magnetic resonance imaging (MRI) with native T1 , T2 , and T2* maps at 4 ± 2 days...
February 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28196494/assessment-of-myocardial-injury-after-reperfused-infarction-by-t1%C3%AF-cardiovascular-magnetic-resonance
#8
Rutger H Stoffers, Marie Madden, Mohammed Shahid, Francisco Contijoch, Joseph Solomon, James J Pilla, Joseph H Gorman, Robert C Gorman, Walter R T Witschey
BACKGROUND: The evolution of T1ρ and of other endogenous contrast methods (T2, T1) in the first month after reperfused myocardial infarction (MI) is uncertain. We conducted a study of reperfused MI in pigs to serially monitor T1ρ, T2 and T1 relaxation, scar size and transmurality at 1 and 4 weeks post-MI. METHODS: Ten Yorkshire swine underwent 90 min of occlusion of the circumflex artery and reperfusion. T1ρ, T2 and native T1 maps and late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) data were collected at 1 week (n = 10) and 4 weeks (n = 5)...
February 15, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28159689/investigation-of-the-confounding-effects-of-vasculature-and-metabolism-on-computational-anatomy-studies
#9
C L Tardif, C J Steele, L Lampe, P-L Bazin, P Ragert, A Villringer, C J Gauthier
Computational anatomy studies typically use T1-weighted magnetic resonance imaging contrast to look at local differences in cortical thickness or grey matter volume across time or subjects. This type of analysis is a powerful and non-invasive tool to probe anatomical changes associated with neurodevelopment, aging, disease or experience-induced plasticity. However, these comparisons could suffer from biases arising from vascular and metabolic subject- or time-dependent differences. Differences in blood flow and volume could be caused by vasodilation or differences in vascular density, and result in a larger signal contribution of the blood compartment within grey matter voxels...
February 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28152255/relationship-between-aging-and-t1-relaxation-time-in-deep-gray-matter-a-voxel-based-analysis
#10
Gosuke Okubo, Tomohisa Okada, Akira Yamamoto, Yasutaka Fushimi, Tsutomu Okada, Katsutoshi Murata, Kaori Togashi
PURPOSE: To investigate age-related changes in T1 relaxation time in deep gray matter structures in healthy volunteers using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE). MATERIALS AND METHODS: In all, 70 healthy volunteers (aged 20-76, mean age 42.6 years) were scanned at 3T magnetic resonance imaging (MRI). A MP2RAGE sequence was employed to quantify T1 relaxation times. After the spatial normalization of T1 maps with the diffeomorphic anatomical registration using the exponentiated Lie algebra algorithm, voxel-based regression analysis was conducted...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28152237/native-t1-value-in-the-remote-myocardium-is-independently-associated-with-left-ventricular-dysfunction-in-patients-with-prior-myocardial-infarction
#11
Shiro Nakamori, Javid Alakbarli, Steven Bellm, Shweta R Motiwala, Gifty Addae, Warren J Manning, Reza Nezafat
PURPOSE: To compare remote myocardium native T1 in patients with chronic myocardial infarction (MI) and controls without MI and to elucidate the relationship of infarct size and native T1 in the remote myocardium for the prediction of left ventricular (LV) systolic dysfunction after MI. MATERIALS AND METHODS: A total of 41 chronic MI (18 anterior MI) patients and 15 age-matched volunteers with normal LV systolic function and no history of MI underwent cardiac magnetic resonance imaging (MRI) at 1...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28152227/3d-myocardial-t1-mapping-using-saturation-recovery
#12
Giovanna Nordio, Markus Henningsson, Amedeo Chiribiri, Adriana D M Villa, Torben Schneider, René M Botnar
PURPOSE: To propose a 3D quantitative high-resolution T1 mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1 phantom and in healthy subjects. MATERIALS AND METHODS: The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28148973/detection-of-changes-in-semi-natural-grasslands-by-cross-correlation-analysis-with-worldview-2-images-and-new-landsat-8-data
#13
Cristina Tarantino, Maria Adamo, Richard Lucas, Palma Blonda
Focusing on a Mediterranean Natura 2000 site in Italy, the effectiveness of the cross correlation analysis (CCA) technique for quantifying change in the area of semi-natural grasslands at different spatial resolutions (grain) was evaluated. In a fine scale analysis (2 m), inputs to the CCA were a) a semi-natural grasslands layer extracted from an existing validated land cover/land use (LC/LU) map (1:5000, time T1) and b) a more recent single date very high resolution (VHR) WorldView-2 image (time T2), with T2 > T1...
March 15, 2016: Remote Sensing of Environment
https://www.readbyqxmd.com/read/28144400/cutting-edge-clinical-applications-in-cardiovascular-magnetic-resonance
#14
EDITORIAL
Carlo N De Cecco, Giuseppe Muscogiuri, Akos Varga-Szemes, U Joseph Schoepf
Today, the use of cardiovascular magnetic resonance (CMR) is widespread in clinical practice. The increased need to evaluate of subtle myocardial changes, coronary artery anatomy, and hemodynamic assessment has prompted the development of novel CMR techniques including T1 and T2 mapping, non-contrast angiography and four dimensional (4D) flow. T1 mapping is suitable for diagnosing pathologies affecting extracellular volume such as myocarditis, diffuse myocardial fibrosis and amyloidosis, and is a promising diagnostic tool for patients with iron overload and Fabry disease...
January 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28143545/histological-validation-of-cardiovascular-magnetic-resonance-t1-mapping-markers-of-myocardial-fibrosis-in-paediatric-heart-transplant-recipients
#15
Seiko Ide, Eugenie Riesenkampff, David A Chiasson, Anne I Dipchand, Paul F Kantor, Rajiv R Chaturvedi, Shi-Joon Yoo, Lars Grosse-Wortmann
BACKGROUND: Adverse fibrotic remodeling is detrimental to myocardial health and a reliable method for monitoring the development of fibrotic remodeling may be desirable during the follow-up of patients after heart transplantation (HTx). Quantification of diffuse myocardial fibrosis with cardiovascular magnetic resonance (CMR) has been increasingly applied and validated histologically in adult patients with heart disease. However, comparisons of CMR findings with histological fibrosis burden in children are lacking...
February 1, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28138816/cardiac-molli-t1-mapping-at-3-0-t-comparison-of-patient-adaptive-dual-source-rf-and-conventional-rf-transmission
#16
Michael Rasper, Jonathan Nadjiri, Alexandra S Sträter, Marcus Settles, Karl-Ludwig Laugwitz, Ernst J Rummeny, Armin M Huber
To prospectively compare image quality and myocardial T1 relaxation times of modified Look-Locker inversion recovery (MOLLI) imaging at 3.0 T (T) acquired with patient-adaptive dual-source (DS) and conventional single-source (SS) radiofrequency (RF) transmission. Pre- and post-contrast MOLLI T1 mapping using SS and DS was acquired in 27 patients. Patient wise and segment wise analysis of T1 times was performed. The correlation of DS MOLLI measurements with a reference spin echo sequence was analysed in phantom experiments...
January 30, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28130644/clinical-applications-of-multi-parametric-cmr-in-myocarditis-and-systemic-inflammatory-diseases
#17
Jakub Lagan, Matthias Schmitt, Christopher A Miller
Cardiac magnetic resonance (CMR) has changed the management of suspected viral myocarditis by providing a 'positive' diagnostic test and has lead to new insights into myocardial involvement in systemic inflammatory conditions. In this review we analyse the use of CMR tissue characterisation techniques across the available studies including T2 weighted imaging, early gadolinium enhancement, late gadolinium enhancement, Lake Louise Criteria, T2 mapping, T1 mapping and extracellular volume assessment. We also discuss the use of multiparametric CMR in acute cardiac transplant rejection and a variety of inflammatory conditions such as sarcoidosis, systemic lupus erythrematous, rheumatoid arthritis and systemic sclerosis...
January 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28129067/radiologic-pathologic-correlation-of-primary-and-secondary-cardiomyopathies-mr-imaging-and-histopathologic-findings-in-hearts-from-autopsy-and-transplantation
#18
Hiromi Hashimura, Fumiko Kimura, Hatsue Ishibashi-Ueda, Yoshiaki Morita, Masahiro Higashi, Shintaro Nakano, Atsushi Iguchi, Kensuke Uotani, Kazuro Sugimura, Hiroaki Naito
Cardiac magnetic resonance (MR) imaging with late gadolinium enhancement (LGE) is used to detect and assess the myocardial damage seen with a variety of cardiomyopathies. Gadolinium-based contrast material accumulates in the expanded interstitial space of the myocardium. Areas with LGE correspond to replacement fibrosis, fibrofatty change, epithelioid granuloma, inflammatory cell infiltration, cardiomyocyte necrosis, and amyloid deposition-conditions that represent a focal increase in interstitial space. Areas without LGE correspond to interstitial or plexiform fibrosis, mildly degenerated cardiomyocytes, inflammatory cell infiltration, and diffuse amyloid deposition-conditions that represent diffuse increases in interstitial space...
January 27, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28116233/longitudinal-changes-of-cortical-microstructure-in-parkinson-s-disease-assessed-with-t1-relaxometry
#19
Lucas Nürnberger, René-Maxime Gracien, Pavel Hok, Stephanie-Michelle Hof, Udo Rüb, Helmuth Steinmetz, Rüdiger Hilker, Johannes C Klein, Ralf Deichmann, Simon Baudrexel
BACKGROUND: Histological evidence suggests that pathology in Parkinson's disease (PD) goes beyond nigrostriatal degeneration and also affects the cerebral cortex. Quantitative MRI (qMRI) techniques allow the assessment of changes in brain tissue composition. However, the development and pattern of disease-related cortical changes have not yet been demonstrated in PD with qMRI methods. The aim of this study was to investigate longitudinal cortical microstructural changes in PD with quantitative T1 relaxometry...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28113491/optimizing-mr-scan-design-for-model-based-i-t-i-sub-1-sub-i-t-i-sub-2-sub-estimation-from-steady-state-sequences
#20
Gopal Nataraj, Jon-Fredrick Nielsen, Jeffrey Fessler
Rapid, reliable quantification of MR relaxation parameters T1 and T2 is desirable for many clinical applications. Steady-state sequences such as Spoiled Gradient-Recalled Echo (SPGR) and Dual-Echo Steady-State (DESS) are fast and wellsuited for relaxometry because the signals they produce are quite sensitive to T1 and T2 variation. However, T1, T2 estimation with these sequences typically requires multiple scans with varied sets of acquisition parameters. This paper describes a systematic framework for selecting scan types (e...
October 4, 2016: IEEE Transactions on Medical Imaging
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