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https://www.readbyqxmd.com/read/29769051/knee-dgemric-at-7-t-comparison-against-1-5-t-and-evaluation-of-t-1-mapping-methods
#1
Pernilla Peterson, Carl Johan Tiderius, Emma Olsson, Björn Lundin, Lars E Olsson, Jonas Svensson
BACKGROUND: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development...
May 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29760545/quantitative-assessment-of-hepatic-fibrosis-in-chronic-hepatitis-b-and-c-t1-mapping-on-gd-eob-dtpa-enhanced-liver-magnetic-resonance-imaging
#2
Shen Pan, Xiao-Qi Wang, Qi-Yong Guo
AIM: To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C). METHODS: We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29743511/detection-of-recent-myocardial-infarction-using-native-t1-mapping-in-a-swine-model-a-validation-study
#3
Chen Cui, Shuli Wang, Minjie Lu, Xuejing Duan, Hongyue Wang, Liujun Jia, Yue Tang, Arlene Sirajuddin, Sanjay K Prasad, Peter Kellman, Andrew E Arai, Shihua Zhao
Late gadolinium enhancement (LGE) imaging is the currently the gold standard for in-vivo detection of myocardial infarction. However, gadolinium contrast administration is contraindicated in patients with renal insufficiency. We aim to evaluate the diagnostic sensitivity and specificity of this contrast-free MRI technique, native T1 mapping, in detecting recent myocardial infarction versus a reference histological gold standard. Ten pigs underwent CMR at 2 weeks after induced MI. The infarct size and transmural extent of MI was calculated using native T1 maps and LGE images...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735362/mri-with-gadofosveset-a-potential-marker-for-permeability-in-myocardial-infarction
#4
Begoña Lavin, Andrea Protti, Silvia Lorrio, Xuebin Dong, Alkystis Phinikaridou, René M Botnar, Ajay Shah
BACKGROUND AND AIMS: Acute ischemia is associated with myocardial endothelial damage and microvessel formation, resulting in leakage of plasma albumin into the myocardial extravascular space. In this study, we tested whether an albumin-binding intravascular contrast agent (gadofosveset) allows for improved quantification of myocardial permeability compared to the conventional extracellular contrast agent Gd-DTPA using late gadolinium enhancement (LGE) and T1 mapping in vivo. METHODS: MI was induced in C57BL/6 mice (n = 6) and cardiac magnetic resonance imaging (CMR) was performed at 3, 10 and 21 days post-MI using Gd-DTPA and 24 h later using gadofosveset...
April 25, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29734491/oxygenation-sensitive-cardiovascular-magnetic-resonance-in-hypertensive-heart-disease-with-left-ventricular-myocardial-hypertrophy-and-non-left-ventricular-myocardial-hypertrophy-insight-from-altered-mechanics-and-cardiac-bold-imaging
#5
Bing-Hua Chen, Rui Wu, Dong-Aolei An, Ruo-Yang Shi, Qiu-Ying Yao, Qing Lu, Jiani Hu, Meng Jiang, James Deen, Ankush Chandra, Jian-Rong Xu, Lian-Ming Wu
BACKGROUND: BOLD (blood oxygen level dependent) MRI can detect regional condition of myocardial oxygen supply and demand by means of paramagnetic properties. PURPOSE: Noninvasive assessment of myocardial oxygenation by BOLD MRI in hypertensive patients with hypertension (HTN) left ventricular myocardial hypertrophy (LVMH) and HTN non-LVMH and its correlation with myocardial mechanics were performed. STUDY TYPE: Prospective. POPULATION: Twenty patients with HTN LVMH, 21 patients with HTN non-LVMH, and 23 normotensive controls were enrolled...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29730991/feasibility-of-cardiovascular-magnetic-resonance-to-detect-oxygenation-deficits-in-patients-with-multi-vessel-coronary-artery-disease-triggered-by-breathing-maneuvers
#6
Kady Fischer, Kyohei Yamaji, Silvia Luescher, Yasushi Ueki, Bernd Jung, Hendrik von Tengg-Kobligk, Stephan Windecker, Matthias G Friedrich, Balthasar Eberle, Dominik P Guensch
BACKGROUND: Hyperventilation with a subsequent breath-hold has been successfully used as a non-pharmacological vasoactive stimulus to induce changes in myocardial oxygenation. The purpose of this pilot study was to assess if this maneuver is feasible in patients with multi-vessel coronary artery disease (CAD), and if it is effective at detecting coronary artery stenosis > 50% determined by quantitative coronary angiography (QCA). METHODS: Twenty-six patients with coronary artery stenosis (QCA > 50% diameter stenosis) underwent a contrast-free cardiovascular magnetic resonance (CMR) exam in the time interval between their primary coronary angiography and a subsequent percutaneous coronary intervention (PCI, n = 24) or coronary artery bypass (CABG, n = 2) revascularization procedure...
May 7, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29724761/postcontrast-t1-mapping-for-differential-diagnosis-of-recurrence-and-radionecrosis-after-gamma-knife-radiosurgery-for-brain-metastasis
#7
B Wang, Y Zhang, B Zhao, P Zhao, M Ge, M Gao, F Ding, S Xu, Y Liu
BACKGROUND AND PURPOSE: The differential diagnosis of radionecrosis and tumor recurrence in brain metastases is challenging. We investigated the diagnostic efficiency of postcontrast T1 mapping in solving this problem. MATERIALS AND METHODS: Between March 2016 and June 2017, fifty-six patients with brain metastases who underwent contrast-enhanced cerebral T1 mapping were recruited for this prospective study. The findings revealed new enhancement after gamma knife radiosurgery...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29721645/midazolam-increases-preload-dependency-during-endotoxic-shock-in-rabbits-by-affecting-venous-vascular-tone
#8
Jianxiao Chen, Tao Yu, Federico Longhini, Xiwen Zhang, Songqiao Liu, Ling Liu, Yi Yang, Haibo Qiu
BACKGROUND: Septic patients often require sedation in intensive care unit, and midazolam is one of the most frequently used sedatives among them. But the interaction between midazolam and septic shock is not known. The aim of this study is to investigate the effects of midazolam on preload dependency in an endotoxic shock model by evaluating systemic vascular tone and cardiac function. METHODS: Eighteen rabbits were randomly divided into three groups: Control group, MID1 group and MID2 group...
May 2, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29713767/monitoring-skeletal-muscle-chronic-fatty-degenerations-with-fast-t1-mapping
#9
Benjamin Marty, Bertrand Coppa, Pierre G Carlier
OBJECTIVES: To develop a fast, high-resolution T1-mapping sequence dedicated to skeletal muscle imaging, and to evaluate the potential of T1 as a robust and sensitive biomarker for the monitoring of chronic fatty degenerations in a dystrophic disease. METHODS: The magnetic resonance imaging sequence consisted of the acquisition of a 1,000-radial-spokes FLASH echo-train following magnetisation inversion, resulting in 10s scan time per slice. Temporal image series were reconstructed using compressed sensing and T1 maps were computed using Bloch simulations...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29705280/comparison-of-t1-mapping-and-t1rho-values-with-conventional-diffusion-weighted-imaging-to-assess-fibrosis-in-a-rat-model-of-unilateral-ureteral-obstruction
#10
Genwen Hu, Wen Liang, Mingxiang Wu, Caiyong Lai, Yingjie Mei, Yufa Li, Jianmin Xu, Liangping Luo, Xianyue Quan
RATIONALE AND OBJECTIVES: The aim of this study was to investigate the potential of magnetic resonance imaging (MRI) T1 mapping and T1 relaxation time in the rotating frame (T1rho) for assessment of renal fibrosis in a rat model of unilateral ureteral obstruction (UUO). MATERIALS AND METHODS: UUO was created in 36 rats. Six rats were scanned at each of the six time points (on days 0, 1, 3, 5, 10, and 15 after UUO). The contralateral kidneys were examined as controls...
April 25, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29688154/use-of-myocardial-t1-mapping-at-3-0-t-to-differentiate-anderson-fabry-disease-from-hypertrophic-cardiomyopathy
#11
Gauri R Karur, Sean Robison, Robert M Iwanochko, Chantal F Morel, Andrew M Crean, Paaladinesh Thavendiranathan, Elsie T Nguyen, Shobhit Mathur, Syed Wasim, Kate Hanneman
Purpose To compare left ventricular (LV) and right ventricular (RV) 3.0-T cardiac magnetic resonance (MR) imaging T1 values in Anderson-Fabry disease (AFD) and hypertrophic cardiomyopathy (HCM) and evaluate the diagnostic value of native T1 values beyond age, sex, and conventional imaging features. Materials and Methods For this prospective study, 30 patients with gene-positive AFD (37% male; mean age ± standard deviation, 45.0 years ± 14.1) and 30 patients with HCM (57% male; mean age, 49.3 years ± 13.5) were prospectively recruited between June 2016 and September 2017 to undergo cardiac MR imaging T1 mapping with a modified Look-Locker inversion recovery (MOLLI) acquisition scheme at 3...
April 24, 2018: Radiology
https://www.readbyqxmd.com/read/29681243/association-between-myocardial-extracellular-volume-and-strain-analysis-through-cardiovascular-magnetic-resonance-with-histological-myocardial-fibrosis-in-patients-awaiting-heart-transplantation
#12
Yue Cui, Yukun Cao, Jing Song, Nianguo Dong, Xiangchuang Kong, Jing Wang, Yating Yuan, Xiaolei Zhu, Xu Yan, Andreas Greiser, Heshui Shi, Ping Han
BACKGROUND: Cardiovascular magnetic resonance (CMR)-derived extracellular volume (ECV) and tissue tracking strain analyses are proposed as non-invasive methods for quantifying myocardial fibrosis and deformation. This study sought (1) to histologically validate myocardial ECV against the collagen volume fraction (CVF) measured from tissue samples of patients undergoing heart transplantation and (2) to detect the correlations between myocardial systolic strain and the myocardial ECV and histological CVF in patients undergoing heart transplantation...
April 23, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29680337/t1-mapping-by-cardiac-magnetic-resonance-and-multidimensional-speckle-tracking-strain-by-echocardiography-for-the-detection-of-acute-cellular-rejection-in-cardiac-allograft-recipients
#13
Leyla Elif Sade, Tuncay Hazirolan, Hatice Kozan, Handan Ozdemir, Mutlu Hayran, Serpil Eroglu, Bahar Pirat, Atilla Sezgin, Haldun Muderrisoglu
OBJECTIVES: The aim of this study was to test the hypothesis that echocardiographic strain imaging, by tracking subtle alterations in myocardial function, and cardiac magnetic resonance T1 mapping, by quantifying tissue properties, are useful and complement each other to detect acute cellular rejection in heart transplant recipients. BACKGROUND: Noninvasive alternatives to endomyocardial biopsy are highly desirable to monitor acute cellular rejection. METHODS: Surveillance endomyocardial biopsies, catheterizations, and echocardiograms performed serially according to institutional protocol since transplantation were retrospectively reviewed...
April 14, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29673122/native-myocardial-t1-time-can-predict-development-of-subsequent-anthracycline-induced-cardiomyopathy
#14
Fabian Muehlberg, Stephanie Funk, Leonora Zange, Florian von Knobelsdorff-Brenkenhoff, Edyta Blaszczyk, Alexander Schulz, Saeed Ghani, Annete Reichardt, Peter Reichardt, Jeanette Schulz-Menger
AIMS: This study aims to assess subclinical changes in functional and morphological myocardial magnetic resonance parameters very early into an anthracycline treatment, which may predict subsequent development of anthracycline-induced cardiomyopathy (aCMP). METHODS AND RESULTS: Thirty sarcoma patients with planned anthracycline-based chemotherapy (360-400 mg/m2 doxorubicin-equivalent) were recruited. Median treatment time was 19.1 ± 2.1 weeks. Enrolled individuals received three cardiovascular magnetic resonance studies (before treatment, 48 h after first anthracycline treatment, and upon completion of treatment)...
April 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29672922/myocardial-perfusion-quantification-using-simultaneously-acquired-13-nh-3-ammonia-pet-and-dynamic-contrast-enhanced-mri-in-patients-at-rest-and-stress
#15
Karl P Kunze, Stephan G Nekolla, Christoph Rischpler, Shelley HuaLei Zhang, Carmel Hayes, Nicolas Langwieser, Tareq Ibrahim, Karl-Ludwig Laugwitz, Markus Schwaiger
PURPOSE: Systematic differences with respect to myocardial perfusion quantification exist between DCE-MRI and PET. Using the potential of integrated PET/MRI, this study was conceived to compare perfusion quantification on the basis of simultaneously acquired 13 NH3 -ammonia PET and DCE-MRI data in patients at rest and stress. METHODS: Twenty-nine patients were examined on a 3T PET/MRI scanner. DCE-MRI was implemented in dual-sequence design and additional T1 mapping for signal normalization...
April 19, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29668414/can-t1-mapping-be-used-to-differentiate-between-acute-and-chronic-myocardial-infarctions
#16
COMMENT
Carlo Tessa, Giancarlo Casolo, Jacopo Del Meglio, Stefano Diciotti, Claudio Vignali, Marco Giannelli
No abstract text is available yet for this article.
May 2018: Radiology
https://www.readbyqxmd.com/read/29665420/distortion-matched-t-1-maps-and-unbiased-t-1-weighted-images-as-anatomical-reference-for-high-resolution-fmri
#17
Wietske van der Zwaag, Pieter F Buur, Alessio Fracasso, Tessa van Doesum, Kamil Uludag, Maarten Versluis, José P Marques
The increasing availability of ultra-high field scanners has led to a growing number of submillimetre fMRI studies in humans, typically targeting the gray matter at different cortical depths. In most analyses, the definition of surfaces at different cortical depths is based on an anatomical image with different contrast and distortions than the functional images. Here, we introduce a novel sequence providing bias-field corrected T1 -weighted images and T1 -maps with distortions that match those of the fMRI data, with an image acquisition time significantly shorter than standard T1 -weighted anatomical imaging...
April 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29657146/absence-of-fibrosis-and-inflammation-by-cardiac-magnetic-resonance-imaging-in-rheumatoid-arthritis-patients-with-low-to-moderate-disease-activity
#18
William Bradham, Michelle J Ormseth, Comfort Elumogo, Srikanth Palanisamy, Chia-Ying Liu, Mark A Lawson, Jonathan H Soslow, Nadine Kawel-Boehm, David A Bluemke, C Michael Stein
OBJECTIVE: The prevalence of heart failure is increased 2-fold in patients with rheumatoid arthritis (RA); this is not explained by ischemic heart disease or other risk factors for heart failure. We hypothesized that in patients with RA without known heart disease, cardiac magnetic resonance imaging (cMRI) would detect altered cardiac structure, function, and fibrosis. METHODS: We performed 1.5-T cMRI in 59 patients with RA and 56 controls frequency-matched for age, race, and sex, and compared cMRI indices of structure, function, and fibrosis [late gadolinium enhancement (LGE), native T1 mapping, and extracellular volume (ECV)] using Mann-Whitney U tests and linear regression, adjusting for age, race, and sex...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29627741/effects-of-renal-sympathetic-denervation-on-myocardial-structure-function-and-perfusion-a-serial-cmr-study
#19
Sinny Delacroix, Ramesh G Chokka, Adam J Nelson, Dennis T Wong, Stephen Pederson, Joanne Nimmo, Adil Rajwani, Kerry Williams, Karen S Teo, Stephen G Worthley
BACKGROUND AND AIMS: Echocardiographic studies have shown improvements in cardiac indices associated with renal sympathetic denervation (RDN), however, the benefits on myocardial perfusion have never been assessed. This trial was designed to study the effects of RDN on myocardial perfusion using cardiac magnetic resonance (CMR) imaging. METHODS: A total of 14 patients with resistant hypertension were recruited for RDN and myocardial perfusion, alongside other CMR indices, was assessed at baseline and at 6 months...
March 10, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29617988/myocardial-native-t1-and-extracellular-volume-with-healthy-ageing-and-gender
#20
Stefania Rosmini, Heerajnarain Bulluck, Gabriella Captur, Thomas A Treibel, Amna Abdel-Gadir, Anish N Bhuva, Veronica Culotta, Ahmed Merghani, Marianna Fontana, Viviana Maestrini, Anna S Herrey, Kelvin Chow, Richard B Thompson, Stefan K Piechnik, Peter Kellman, Charlotte Manisty, James C Moon
Aims: To determine how native myocardial T1 and extracellular volume (ECV) change with age, both to understand aging and to inform on normal reference ranges. Methods and results: Ninety-four healthy volunteers with no a history or symptoms of cardiovascular disease or diabetes underwent cardiovascular magnetic resonance at 1.5 T. Mid-ventricular short axis native and post-contrast T1 maps by Shortened MOdified Look-Locker Inversion-recovery (ShMOLLI), MOdified Look-Locker Inversion Recovery (MOLLI) [pre-contrast: 5s(3s)3s, post-contrast: 4s(1s)3s(1s)2s] and saturation recovery single-shot acquisition (SASHA) were acquired and ECV by these three techniques were derived for the mid anteroseptum...
March 30, 2018: European Heart Journal Cardiovascular Imaging
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