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t1-mapping

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https://www.readbyqxmd.com/read/28644903/changes-in-remote-myocardial-tissue-after-acute-myocardial-infarction-and-its-relation-to-cardiac-remodeling-a-cmr-t1-mapping-study
#1
P Stefan Biesbroek, Raquel P Amier, Paul F A Teunissen, Mark B M Hofman, Lourens F H J Robbers, Peter M van de Ven, Aernout M Beek, Albert C van Rossum, Niels van Royen, Robin Nijveldt
OBJECTIVES: To characterize the temporal alterations in native T1 and extracellular volume (ECV) of remote myocardium after acute myocardial infarction (AMI), and to explore their relation to left ventricular (LV) remodeling. METHODS: Forty-two patients with AMI successfully treated with primary PCI underwent cardiovascular magnetic resonance after 4-6 days and 3 months. Cine imaging, late gadolinium enhancement, and T1-mapping (MOLLI) was performed at 1.5T. T1 values were measured in the myocardial tissue opposite of the infarct area...
2017: PloS One
https://www.readbyqxmd.com/read/28642994/cardiovascular-magnetic-resonance-imaging-to-assess-myocardial-fibrosis-in-valvular-heart-disease
#2
Tomaz Podlesnikar, Victoria Delgado, Jeroen J Bax
The left ventricular (LV) remodeling process associated with significant valvular heart disease (VHD) is characterized by an increase of myocardial interstitial space with deposition of collagen and loss of myofibers. These changes occur before LV systolic function deteriorates or the patient develops symptoms. Cardiovascular magnetic resonance (CMR) permits assessment of reactive fibrosis, with the use of T1 mapping techniques, and replacement fibrosis, with the use of late gadolinium contrast enhancement...
June 22, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28629574/biventricular-mechanics-in-prediction-of-severe-myocardial-fibrosis-in-patients-with-dilated-cardiomyopathy-cmr-study
#3
Łukasz Mazurkiewicz, Joanna Petryka, Mateusz Spiewak, Barbara Miłosz-Wieczorek, Konrad Werys, Łukasz A Małek, Magdalena Polanska-Skrzypczyk, Natalia Ojrzynska, Agata Kubik, Magdalena Marczak, Jolanta Misko, Jacek Grzybowski
PURPOSE: The purpose of this study was to compare the ability of various parameters of myocardial mechanics to predict large amounts of biventricular fibrosis assessed via T1 mapping in patients with dilated cardiomyopathy (DCM). MATERIAL: Cardiovascular magnetic resonance feature tracking analysis and T1 mapping were performed in 26 patients with DCM [mean age: 34.4±9.1years, 15 (57.6%) males]. The values of various parameters of myocardial mechanics at predicting advanced left-ventricle (LV) and right-ventricle (RV) fibrosis were compared using logistic regression analysis and receiver operating characteristic curve (ROC) analysis...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624408/native-t1-mapping-and-extracellular-volume-mapping-for-the-assessment-of-diffuse-myocardial-fibrosis-in-dilated%C3%A2-cardiomyopathy
#4
Shiro Nakamori, Kaoru Dohi, Masaki Ishida, Yoshitaka Goto, Kyoko Imanaka-Yoshida, Taku Omori, Itaru Goto, Naoto Kumagai, Naoki Fujimoto, Yasutaka Ichikawa, Kakuya Kitagawa, Norikazu Yamada, Hajime Sakuma, Masaaki Ito
OBJECTIVES: The purpose of this study was to examine the histological correlation of native myocardial T1 and extracellular volume fraction (ECV) measurement at 3-T for the assessment of diffuse pathological changes in the myocardial tissue, including myocardial fibrosis and extracellular space in dilated cardiomyopathy (DCM). BACKGROUND: Cardiac magnetic resonance T1 techniques allow the quantification of diffuse myocardial fibrosis. However, there are no definitive head-to-head studies of native T1 versus ECV for the detection, quantification, and characterization of pathological changes in the myocardial tissue in DCM by using histological samples for confirmation...
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28624398/prognostic-significance-of-remote-myocardium-alterations-assessed-by-quantitative-noncontrast-t1-mapping-in-st-segment-elevation-myocardial-infarction
#5
Sebastian J Reinstadler, Thomas Stiermaier, Johanna Liebetrau, Georg Fuernau, Charlotte Eitel, Suzanne de Waha, Steffen Desch, Jan-Christian Reil, Janine Pöss, Bernhard Metzler, Christian Lücke, Matthias Gutberlet, Gerhard Schuler, Holger Thiele, Ingo Eitel
OBJECTIVES: This study assessed the prognostic significance of remote zone native T1 alterations for the prediction of clinical events in a population with ST-segment elevation myocardial infarction (STEMI) who were treated by primary percutaneous coronary intervention (PPCI) and compared it with conventional markers of infarct severity. BACKGROUND: The exact role and incremental prognostic relevance of remote myocardium native T1 mapping alterations assessed by cardiac magnetic resonance (CMR) after STEMI remains unclear...
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28624009/measuring-hepatic-functional-reserve-using-t1-mapping-of-gd-eob-dtpa-enhanced-3t-mr-imaging-a-preliminary-study-comparing-with-99m-tc-gsa-scintigraphy-and-signal-intensity-based-parameters
#6
Masataka Nakagawa, Tomohiro Namimoto, Kie Shimizu, Kosuke Morita, Fumi Sakamoto, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Shinya Shiraishi, Yasuyuki Yamashita
PURPOSE: To determine the utility of liver T1-mapping on gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance (MR) imaging for the measurement of liver functional reserve compared with the signal intensity (SI) based parameters, technetium-99m-galactosyl serum albumin ((99m)Tc-GSA) scintigraphy and indocyanine green (ICG) clearance. MATERIALS AND METHODS: This retrospective study included 111 patients (Child-Pugh-A 90; -B 21) performed with both Gd-EOB-DTPA enhanced liver MR imaging and (99m)Tc-GSA (76 patients with ICG)...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28623475/t1-mapping-in-cardiac-mri
#7
REVIEW
Dina Radenkovic, Sebastian Weingärtner, Lewis Ricketts, James C Moon, Gabriella Captur
Quantitative myocardial and blood T1 have recently achieved clinical utility in numerous pathologies, as they provide non-invasive tissue characterization with the potential to replace invasive biopsy. Native T1 time (no contrast agent), changes with myocardial extracellular water (edema, focal or diffuse fibrosis), fat, iron, and amyloid protein content. After contrast, the extracellular volume fraction (ECV) estimates the size of the extracellular space and identifies interstitial disease. Spatially resolved quantification of these biomarkers (so-called T1 mapping and ECV mapping) are steadily becoming diagnostic and prognostically useful tests for several heart muscle diseases, influencing clinical decision-making with a pending second consensus statement due mid-2017...
June 16, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28623409/evaluation-of-bone-viability-in-patients-after-girdlestone-arthroplasty-comparison-of-bone-spect-ct-and-mri
#8
G Diederichs, P Hoppe, F Collettini, G Wassilew, B Hamm, W Brenner, M R Makowski
PURPOSE: To test the diagnostic performance of bone SPECT/CT and MRI for the evaluation of bone viability in patients after girdlestone-arthroplasty with histopathology used as gold standard. MATERIALS AND METHODS: In this cross-sectional study, patients after girdlestone-arthroplasty were imaged with single-photon-emission-computed-tomography/computed-tomography (SPECT/CT) bone-scans using 99mTc-DPD. Additionally, 1.5 T MRI was performed with turbo-inversion-recovery-magnitude (TIRM), contrast-enhanced T1-fat sat (FS) and T1-mapping...
June 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28620681/cardiac-t1-mapping-in-congenital-heart-disease-bolus-vs-infusion-protocols-for-measurements-of-myocardial-extracellular-volume-fraction
#9
Nadya Al-Wakeel-Marquard, Sanaz Rastin, Frédéric Muench, Darach O H-Ici, Sevim Yilmaz, Felix Berger, Titus Kuehne, Daniel R Messroghli
Myocardial extracellular volume fraction (ECV) reflecting diffuse myocardial fibrosis can be measured with T1 mapping cardiovascular magnetic resonance (CMR) before and after the application of a gadolinium-based extracellular contrast agent. The equilibrium between blood and myocardium contrast concentration required for ECV measurements can be obtained with a primed contrast infusion (equilibrium contrast-CMR). We hypothesized that equilibrium can also be achieved with a single contrast bolus to accurately measure diffuse myocardial fibrosis in patients with congenital heart disease (CHD)...
June 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28620142/magnetic-resonance-imaging-of-rrx-001-pharmacodynamics-in-preclinical-tumors
#10
Natarajan Raghunand, Jan Scicinski, Gerald P Guntle, Bhumasamudram Jagadish, Eugene A Mash, Elizabeth Bruckheimer, Bryan Oronsky, Ronald L Korn
RRx-001 is an anticancer agent that subjects cancer cells to reactive oxygen/nitrogen species (ROS/RNS) and acts as an epigenetic modifier. We have used a thiol-bearing MRI contrast agent, Gd-LC7-SH, to investigate the pharmacodynamics of RRx-001 in CHP-100 Ewing's Sarcoma, HT-29 colorectal carcinoma, and PANC-1 pancreatic carcinoma xenografts in SCID mice. Binding of Gd-LC7-SH to the Cys34 residue on plasma albumin prolongs retention in the tumor microenvironment and increases tumor enhancement on MRI. Mice were imaged by MRI and in vivo T1 maps acquired 50 min (T150 min) after injection of 0...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28616730/contrast-enhanced-3t-mr-perfusion-of-musculoskeletal-tumours-t1-value-heterogeneity-assessment-and-evaluation-of-the-influence-of-t1-estimation-methods-on-quantitative-parameters
#11
Pedro Augusto Gondim Teixeira, Christophe Leplat, Bailiang Chen, Jacques De Verbizier, Marine Beaumont, Sammy Badr, Anne Cotten, Alain Blum
OBJECTIVE: To evaluate intra-tumour and striated muscle T1 value heterogeneity and the influence of different methods of T1 estimation on the variability of quantitative perfusion parameters. MATERIAL AND METHODS: Eighty-two patients with a histologically confirmed musculoskeletal tumour were prospectively included in this study and, with ethics committee approval, underwent contrast-enhanced MR perfusion and T1 mapping. T1 value variations in viable tumour areas and in normal-appearing striated muscle were assessed...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28610912/characteristics-of-cardiomyopathy-in-alstr%C3%A3-m-syndrome-prospective-single-center-data-on-38-patients
#12
Alessandra Brofferio, Vandana Sachdev, Hwaida Hannoush, Jan D Marshall, Jürgen K Naggert, Stanislav Sidenko, Anna Noreuil, Arlene Sirajuddin, Joy Bryant, Joan C Han, Andrew E Arai, William A Gahl, Meral Gunay-Aygun
BACKGROUND: Alström syndrome (AS) is a rare monogenetic disorder with multi-organ involvement. Complex metabolic disturbances are common and cardiomyopathy is a well-recognized feature in infants as well as in older children and adults. Although the mechanism of cardiomyopathy is not known, previous reports suggest that individuals with infantile-onset cardiac disease recover completely. METHODS: In this single center prospective series of 38 children and adults (age range 1...
May 30, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28603934/model-based-t1-mapping-with-sparsity-constraints-using-single-shot-inversion-recovery-radial-flash
#13
Xiaoqing Wang, Volkert Roeloffs, Jakob Klosowski, Zhengguo Tan, Dirk Voit, Martin Uecker, Jens Frahm
PURPOSE: To develop a model-based reconstruction technique for single-shot T1 mapping with high spatial resolution, accuracy, and precision using an inversion-recovery (IR) fast low-angle shot (FLASH) acquisition with radial encoding. METHODS: The proposed model-based reconstruction jointly estimates all model parameters, that is, the equilibrium magnetization, steady-state magnetization, 1/ T1*, and all coil sensitivities from the data of a single-shot IR FLASH acquisition with a small golden-angle radial trajectory...
June 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28599831/alterations-in-cardiac-deformation-timing-of%C3%A2-contraction-and-relaxation-and-early-myocardial-fibrosis-accompany-the-apparent-recovery-of-acute-stress-induced-takotsubo-cardiomyopathy-an-end-to-the-concept-of%C3%A2-transience
#14
Konstantin Schwarz, Trevor Ahearn, Janaki Srinivasan, Christopher J Neil, Caroline Scally, Amelia Rudd, Baljit Jagpal, Michael P Frenneaux, Cristina Pislaru, John D Horowitz, Dana K Dawson
BACKGROUND: Takotsubo syndrome is an increasingly recognized cause of chest pain and occasionally of cardiogenic shock. Despite rapid improvement of the left ventricular (LV) ejection fraction, recent registry data raise concerns about long-term prognosis. The aim of this study was to test the hypothesis that restoration of normal ejection fraction after acute takotsubo syndrome is not equivalent to full functional recovery. METHODS: Fifty-two patients with takotsubo syndrome (according to the Mayo Clinic criteria plus cardiac magnetic resonance imaging to exclude myocardial infarction) and 44 healthy control subjects of the same age, gender, and cardiovascular comorbidity distribution were prospectively recruited...
June 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28589482/sasha-versus-shmolli-a-comparison-of-t1-mapping-methods-in-health-and-dilated-cardiomyopathy-at-3%C3%A2-t
#15
Benedict T Costello, Fabian Springer, James L Hare, Andre La Gerche, Leah Iles, Andris H Ellims, Benjamin Schmitt, Andrew J Taylor
Cardiac Magnetic Resonance derived T1 mapping parameters are a non-invasive method of estimating diffuse myocardial fibrosis. This study aims to to determine the native T1 time, post contrast T1 time and extracellular volume (ECV) derived from T1 mapping and to evaluate the ability of T1 mapping techniques to discriminate healthy myocardium from dilated cardiomyopathy. Seventy-nine participants underwent cardiac magnetic resonance imaging at the Baker Heart and Diabetes Institute, Melbourne, Australia. Fifty-seven healthy volunteers and twenty-two patients with Dilated cardiomyopathy were included in the study...
June 6, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28589126/myocardial-architecture-mechanics-and-fibrosis-in-congenital-heart-disease
#16
REVIEW
Sarah Ghonim, Inga Voges, Peter D Gatehouse, Jennifer Keegan, Michael A Gatzoulis, Philip J Kilner, Sonya V Babu-Narayan
Congenital heart disease (CHD) is the most common category of birth defect, affecting 1% of the population and requiring cardiovascular surgery in the first months of life in many patients. Due to advances in congenital cardiovascular surgery and patient management, most children with CHD now survive into adulthood. However, residual and postoperative defects are common resulting in abnormal hemodynamics, which may interact further with scar formation related to surgical procedures. Cardiovascular magnetic resonance (CMR) has become an important diagnostic imaging modality in the long-term management of CHD patients...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28583883/preferential-susceptibility-of-limbic-cortices-to-microstructural-damage-in-temporal-lobe-epilepsy-a-quantitative-t1-mapping-study
#17
REVIEW
Boris C Bernhardt, Fatemeh Fadaie, Reinder Vos De Wael, Seok-Jun Hong, Min Liu, Marie C Guiot, David A Rudko, Andrea Bernasconi, Neda Bernasconi
The majority of MRI studies in temporal lobe epilepsy (TLE) have utilized morphometry to map widespread cortical alterations. Morphological markers, such as cortical thickness or grey matter density, reflect combinations of biological events largely driven by overall cortical geometry rather than intracortical tissue properties. Because of its sensitivity to intracortical myelin, quantitative measurement of longitudinal relaxation time (qT1) provides and an in vivo proxy for cortical microstructure. Here, we mapped the regional distribution of qT1 in a consecutive cohort of 24 TLE patients and 20 healthy controls...
June 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28580583/simultaneous-multislice-imaging-for-native-myocardial-t1-mapping-improved-spatial-coverage-in-a-single-breath-hold
#18
Sebastian Weingärtner, Steen Moeller, Sebastian Schmitter, Edward Auerbach, Peter Kellman, Chetan Shenoy, Mehmet Akçakaya
PURPOSE: To develop a saturation recovery myocardial T1 mapping method for the simultaneous multislice acquisition of three slices. METHODS: Saturation pulse-prepared heart rate independent inversion recovery (SAPPHIRE) T1 mapping was implemented with simultaneous multislice imaging using FLASH readouts for faster coverage of the myocardium. Controlled aliasing in parallel imaging (CAIPI) was used to achieve minimal noise amplification in three slices. Multiband reconstruction was performed using three linear reconstruction methods: Slice- and in-plane GRAPPA, CG-SENSE, and Tikhonov-regularized CG-SENSE...
June 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28572614/early-detection-and-serial-monitoring-of-anthracycline-induced-cardiotoxicity-using-t1-mapping-cardiac-magnetic-resonance-imaging-an-animal-study
#19
Yoo Jin Hong, Heae Surng Park, Jeffrey Kihyun Park, Kyunghwa Han, Chul Hwan Park, Tai Kyung Kim, Sae Jong Yoo, Ji Yeon Lee, Pan Ki Kim, Jin Hur, Hye-Jeong Lee, Young Jin Kim, Young Joo Suh, Mun Young Paek, Byoung Wook Choi
A reliable, non-invasive diagnostic method is needed for early detection and serial monitoring of cardiotoxicity, a well-known side effect of chemotherapy. This study aimed to assess the feasibility of T1-mapping cardiac magnetic resonance imaging (CMR) for evaluating subclinical myocardial changes in a doxorubicin-induced cardiotoxicity rabbit model. Adult male New Zealand White rabbits were injected twice-weekly with doxorubicin and subjected to CMR on a clinical 3T MR system before and every 2-4 weeks post-drug administration...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28554340/cardiac-mri-t1-mapping-in-unrepaired-anomalous-left-coronary-artery-from-the-pulmonary-artery
#20
Kate Hanneman, Rachel Wald
A 29-year-old gravida1 para1 woman presented with increasing fatigue. Multi-modality imaging demonstrated the left coronary artery arising from the main pulmonary artery with large collateral vessels in the interventricular septum, in keeping with unrepaired anomalous left coronary artery from the pulmonary artery. Cardiac MRI T1 mapping demonstrated globally elevated non-contrast T1 and extracellular volume fraction values, which suggested the presence of diffuse interstitial myocardial fibrosis. Cardiac MRI T1 mapping allows for a new dimension of myocardial characterisation, providing insight into subtle, diffuse abnormalities at the tissue level...
May 30, 2017: Cardiology in the Young
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