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tachycardia-induced cardiomyopathy

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https://www.readbyqxmd.com/read/29759837/clinical-features-and-sites-of-ablation-for-patients-with-incessant-supraventricular-tachycardia-from-concealed-nodofascicular-and-nodoventricular-tachycardias
#1
Frederick T Han, Eric M Riles, Nitish Badhwar, Melvin M Scheinman
OBJECTIVES: This study sought to describe the clinical features and sites of successful ablation for incessant nodofascicular (NF) and nodoventricular (NV) tachycardias. BACKGROUND: Incessant supraventricular tachycardias have been associated with tachycardia-induced cardiomyopathies and have been previously attributed to permanent junctional reciprocating tachycardias, atrial tachycardias, and atrioventricular nodal re-entrant tachycardias. Incessant concealed NF and NV tachycardias have not been described previously...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759543/long-term-outcomes-of-catheter-ablation-of-electrical-storm-in-nonischemic-dilated-cardiomyopathy-compared-with-ischemic-cardiomyopathy
#2
Daniele Muser, Jackson J Liang, Rajeev K Pathak, Silvia Magnani, Simon A Castro, Tatsuya Hayashi, Fermin C Garcia, Gregory E Supple, Michael P Riley, David Lin, Sanjay Dixit, Erica S Zado, David S Frankel, David J Callans, Francis E Marchlinski, Pasquale Santangeli
OBJECTIVES: The goal of this study was to determine the long-term outcomes of catheter ablation (CA) of electrical storm in patients with nonischemic dilated cardiomyopathy (NIDCM) compared with patients with ischemic cardiomyopathy (ICM). BACKGROUND: CA of ventricular tachycardia (VT) electrical storm has been shown to improve VT-free survival in patients with ICM. Data on the outcomes of CA of electrical storm in patients with NIDCM are insufficient. METHODS: The study included 267 consecutive patients with NIDCM (n = 71; ejection fraction 32 ± 14%) and ICM (n = 196; ejection fraction 28 ± 12%)...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29747127/wideband-lge-mri-permits-unobstructed-viewing-of-myocardial-scarring-in-a-patient-with-an-mr-conditional-subcutaneous-implantable-cardioverter-defibrillator
#3
Amir Ali Rahsepar, Jeremy D Collins, Bradley P Knight, KyungPyo Hong, James C Carr, Daniel Kim
A subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative device for prevention of sudden cardiac death, without any leads within the heart. Patients implanted with any type of ICD may need catheter ablation of ventricular tachycardia (VT) to reduce the overall arrhythmia burden (e.g., recurrent monomorphic VT) and lower the incidence of painful shocks induced by the device. Late gadolinium enhancement (LGE) MRI is a useful pre-test for guiding VT ablation, because it can be used to map myocardial scar and produce better outcomes...
May 4, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29742489/renal-denervation-effects-on-myocardial-fibrosis-and-ventricular-arrhythmias-in-rats-with-ischemic-cardiomyopathy
#4
Bin Zhang, Xiaorong Li, Chu Chen, Wanying Jiang, Dasheng Lu, Qian Liu, Kai Wang, Yuhao Yan, Zhixin Jiang, Jie Geng, Hai Xu, Qijun Shan
BACKGROUND/AIMS: To investigate the impact of renal denervation (RDN) on myocardial fibrosis and ventricular arrhythmias (VAs) in rats with ischemic cardiomyopathy. METHODS: An ischemic cardiomyopathy model was reproduced with myocardial infarction (MI) in adult Sprague-Dawley male rats. The RDN/Sham-RDN procedure was performed at 2 weeks after MI. Sham-MI and sham-RDN rats served as the control group. At 4 weeks after RDN, programmed electrical stimulation (PES) was used to induce VAs, including ventricular tachycardia and ventricular fibrillation, in all 3 groups (MI+RDN, MI, and control groups)...
May 5, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29721116/ventricular-tachycardia-storm-originating-from-interventricular-septum-successfully-treated-with-surgical-cryoablation-with-electroanatomic-and-electrophysiological-mapping-before-dual-valve-replacement
#5
Iwanari Kawamura, Seiji Fukamizu, Satoshi Miyazawa, Rintaro Hojo, Fusahiko Ito, Masazumi Watanabe, Mitsuhiro Nishizaki, Harumizu Sakurada, Masayasu Hiraoka
A 58-year-old man with dilated cardiomyopathy was admitted with heart failure. He had a history of two catheter ablation procedures for ventricular tachycardia (VT) originating from the intraventricular septum (IVS). Before dual valve replacement (DVR), he suffered a VT storm. An electrophysiological study revealed an extended low-voltage area at the IVS with the exit of the induced VT at the anterior side. Radiofrequency application was performed at the VT exit as a landmark for surgical cryoablation (SA)...
February 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29718532/the-subcutaneous-implantable-cardioverter-defibrillator-a-tertiary-center-experience
#6
Cesar Khazen, Peter Magnusson, Johannes Flandorfer, Christoph Schukro
BACKGROUND: The aim of the study was to evaluate subcutaneous implantable cardioverter-defibrillator (S-ICD) patients with regard to underlying etiology, peri-procedural outcome, appropriate/inappropriate shocks, and complications during follow-up. METHODS: All patients who underwent S-ICD implantation from February 2013 to March 2017 at an academic hospital in Vienna were included. Medical records were examined and follow-up interrogations of devices were conducted...
May 2, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29713820/diagnostic-value-of-electrocardiographic-p-wave-characteristics-in-atrial-fibrillation-recurrence-and-tachycardia-induced-cardiomyopathy-after-catheter-ablation
#7
Atsushi Doi, Masahiko Takagi, Hisashi Katayama, Tomotaka Yoshiyama, Yusuke Hayashi, Hiroaki Tatsumi, Minoru Yoshiyama
Abnormal P-wave characteristics were reportedly associated with left ventricular interstitial fibrosis as defined by cardiac magnetic resonance images. The objective of this study is to investigate the utility of P-wave characteristics to predict atrial fibrillation (AF) recurrence and the recovery of left ventricular systolic dysfunction (LVSD) after catheter ablation (CA) for AF. Two hundred and five AF patients (109 paroxysmal and 96 persistent) who underwent CA were enrolled. We measured maximum P-wave duration (max PWD) and P-wave terminal force in lead V1 (PTFV1) calculated as a product of P-wave terminal amplitude (PTaV1) and duration (PTdV1) in lead V1 during sinus rhythm...
April 30, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29698683/anticancer-drug-induced-cardiac-rhythm-disorders-current-knowledge-and-basic-underlying-mechanisms
#8
REVIEW
Joachim Alexandre, Javid Moslehi, Kevin R Bersell, Christian Funck-Brentano, Dan M Roden, Joe-Elie Salem
Significant advances in cancer treatment have resulted in decreased cancer related mortality for many malignancies with some cancer types now considered chronic diseases. Despite these improvements, there is increasing recognition that many cancer patients or cancer survivors can develop cardiovascular diseases, either due to the cancer itself or as a result of anticancer therapy. Much attention has focused on heart failure; however, other cardiotoxicities, notably cardiac rhythm disorders, can occur without underlying cardiomyopathy...
April 24, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29656687/longitudinal-evaluation-of-ventricular-ejection-fraction-and-nt-probnp-across-heart-failure-subgroups
#9
Andreas Martinsson, Petter Oest, Maj-Britt Wiborg, Öyvind Reitan, J Gustav Smith
OBJECTIVES: Left ventricular ejection fraction (EF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are important surrogate markers of cardiac function and wall stress. Randomized trials of heart failure (HF) have shown improvements in survival in patients with reduced EF (<40%, HFrEF) but not with preserved EF (≥50%, HFpEF) or mid-range EF (40-49%, HFmrEF). Limited information is available on the trajectory of EF in contemporary heart failure management programs (HFMPs)...
April 14, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29598884/outcome-of-clinical-management-in-relatives-of-sudden-cardiac-death-victims
#10
Katrine M Müllertz, Morten K Christiansen, Anders K Broendberg, Lisbeth N Pedersen, Henrik K Jensen
BACKGROUND: International guidelines recommend clinical assessment of the surviving first-degree relatives of sudden cardiac death (SCD) victims to identify a probable cause of death and protect surviving relatives. Only few studies have reported the outcome of clinical management and follow-up of relatives to SCD victims. METHODS: We performed a retrospective cohort study of the clinical and genetic assessment of surviving relatives of SCD victims referred to the Clinic of Inherited Cardiac Diseases at Aarhus University Hospital, Denmark, between 1995 and 2016...
March 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29590384/atrial-remodelling-and-function-implications-for-atrial-fibrillation-surgery
#11
Stefano Benussi, Gijs E de Maat
The exact mechanism of atrial fibrillation (AF) is still incompletely understood. A number of alterations that impact focal electrical discharge, the atrial substrate and modulating factors contribute to its pathogenesis. Atrial remodelling (resulting in atrial cardiomyopathy) sets the stage for AF development. Once present, AF results in the loss of synchronized atrial contraction, which affects ventricular filling and atrial reservoir and conduit functions. Passive atrial function is particularly important in patients with left ventricular diastolic dysfunction...
April 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29553504/tachycardia-induced-cardiomyopathy-as-a-chronic-heart-failure-model-in-swine
#12
Pavel Hála, Mikuláš Mlček, Petr Ošťádal, David Janák, Michaela Popková, Tomáš Bouček, Stanislav Lacko, Jaroslav Kudlička, Petr Neužil, Otomar Kittnar
A stable and reliable model of chronic heart failure is required for many experiments to understand hemodynamics or to test effects of new treatment methods. Here, we present such a model by tachycardia-induced cardiomyopathy, which can be produced by rapid cardiac pacing in swine. A single pacing lead is introduced transvenously into fully anaesthetized healthy swine, to the apex of the right ventricle, and fixated. Its other end is then tunneled dorsally to the paravertebral region. There, it is connected to an in-house modified heart pacemaker unit that is then implanted in a subcutaneous pocket...
February 17, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29545480/ion-channel-dysfunctions-in-dilated-cardiomyopathy-in-limb-girdle-muscular-dystrophy
#13
Ibrahim El-Battrawy, Zhihan Zhao, Huan Lan, Xin Li, Gökhan Yücel, Siegfried Lang, Katherine Sattler, Jan-Dierk Schünemann, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Karen Bieback, Ralf Bauer, Antonius Ratte, Regina Pribe-Wolferts, Kleopatra Rapti, Daniel Nowak, Janina Wittig, Dierk Thomas, Patrick Most, Hugo A Katus, Ursula Ravens, Constanze Schmidt, Martin Borggrefe, Xiao-Bo Zhou, Oliver J Müller, Ibrahim Akin
BACKGROUND: Limb-Girdle muscular dystrophies (LGMD) are a heritable group of genetically determined disorders with a primary involvement of the pelvic or shoulder girdle musculature with partially cardiac manifestation, such as dilated cardiomyopathy (DCM) and life-threatening tachyarrhythmia. We report here that human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes from a patient with LGMD2I and DCM associated with recurrent ventricular tachycardia displayed ion channel dysfunction and abnormality of calcium homeostasis...
March 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29437800/ventricular-tachyarrhythmia-in-a-78-year-old-woman-with-essential-thrombocythaemia
#14
Mary Rodriguez-Ziccardi, Manolo Rubio, Marvin Lu, Allan Greenspan
Anagrelide is a phosphodiesterase-3 inhibitor used in the treatment of essential thrombocythaemia. Cardiovascular side effects such as ventricular tachycardia and cardiomyopathy are rare but potentially fatal and should be made known to patients before starting the medication. It usually arises within the first 6 months after initiation of therapy and may be dose related. The elderly population are particularly susceptible. These cardiotoxicities result from an increase in cyclic AMP that induces positive inotropic and chronotropic effects and are often reversible with cessation of use...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29408436/predicting-arrhythmic-risk-in-arrhythmogenic-right-ventricular-cardiomyopathy-a-systematic-review-and-meta-analysis
#15
Laurens P Bosman, Arjan Sammani, Cynthia A James, Julia Cadrin-Tourigny, Hugh Calkins, J Peter van Tintelen, Richard N W Hauer, Folkert W Asselbergs, Anneline S J M teRiele
While many studies evaluate predictors of ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC), a systematic review consolidating this evidence is currently lacking. Therefore, we searched MEDLINE and Embase for studies analyzing predictors of ventricular arrhythmias (sustained ventricular tachycardia/fibrillation (VT/VF), appropriate implantable cardioverter-defibrillator therapy, or sudden cardiac death) in patients with definite ARVC, patients with borderline ARVC, and ARVC-associated mutation carriers...
February 3, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29383491/catheter-ablation-of-symptomatic-idiopathic-ventricular-arrhythmias-a-five-year-single-centre-experience
#16
A W G J Oomen, L R C Dekker, A Meijer
AIMS: This study was designed to gain insight into the patient characteristics, results and possible complications of ablation procedures for symptomatic idiopathic premature ventricular complexes (PVC) and idiopathic ventricular tachycardia (VT). METHODS: Data were collected from all patients who underwent radiofrequency catheter ablation for symptomatic PVCs and idiopathic VT in the Catharina Hospital between 1 January 2011 and 31 December 2015. The procedural endpoint was elimination or non-inducibility of the clinical arrhythmia...
April 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29361520/divergent-effects-of-adrenaline-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-obtained-from-hypertrophic-cardiomyopathy
#17
Chandra Prajapati, Marisa Ojala, Katriina Aalto-Setälä
Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disease that affects the heart muscle with diverse clinical outcomes. HCM can cause sudden cardiac death (SCD) during or immediately after mild to rigorous physical activity in young patients. However, the mechanism causing SCD as a result of exercise remains unknown, but exercise-induced ventricular arrhythmias are thought to be responsible for this fatal consequence. To understand the disease mechanism behind HCM in a better way, we generated patient-specific induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from HCM patients carrying either the MYBPC3-Gln1061X or TPM1-Asp175Asn mutation...
February 26, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29326827/premature-ventricular-contraction-induced-cardiomyopathy
#18
David J Callans
Premature ventricular contractions (PVCs) are very common and usually do not require treatment. However, in the clinical setting of troublesome symptoms, or when PVCs trigger polymorphic ventricular tachycardia or cause cardiomyopathy, proper treatment is critical. In this review, the clinical syndrome of PVC-induced cardiomyopathy, including risk factors for development and treatment, is discussed. Although PVC-induced cardiomyopathy is typically associated with frequent PVCs there are also patients with this burden that do not develop cardiomyopathy, suggesting a differential susceptibility...
December 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/29325974/fast-nonclinical-ventricular-tachycardia-inducible-after-ablation-in-patients-with-structural-heart-disease-definition-and-clinical-implications
#19
Masaya Watanabe, Marta de Riva, Sebastiaan R D Piers, Olaf M Dekkers, Micaela Ebert, Jeroen Venlet, Serge A Trines, Martin J Schalij, Daniël A Pijnappels, Katja Zeppenfeld
BACKGROUND: Noninducibility of ventricular tachycardia (VT) with an equal or longer cycle length (CL) than that of the clinical VT is considered the minimum ablation endpoint in patients with structural heart disease. Because their clinical relevance remains unclear, fast nonclinical VTs are often not targeted. However, an accepted definition for fast VT is lacking. The shortest possible CL of a monomorphic reentrant VT is determined by the ventricular refractory period (VRP). OBJECTIVE: The purpose of this study was to propose a patient-specific definition for fast VT based on the individual VRP (fVTVRP ) and assess the prognostic significance of persistent inducibility after ablation of fVTVRP for VT recurrence...
May 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29317972/high-density-mapping-in-ventricular-tachycardia-ablation-a-pentaray-%C3%A2-study
#20
Petra Maagh, Arnd Christoph, Henning Dopp, Markus Sebastian Mueller, Gunnar Plehn, Axel Meissner
Background: High-density mapping of ventricular tachycardia (VT) with PentaRay® (Biosense-Webster) provides high resolution with discrimination of local abnormal electrograms and slow conducting channels. We evaluate the feasibility of PentaRay® to characterize the anatomical substrate and assume an influence of the outcome despite limitations. Methods: Over a 24-month period, 26 endocardial and four epicardial maps were obtained of 26 VT patients (18 ischemic cardiomyopathy (ICM, 69...
December 2017: Cardiology Research
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