David Du Pasquier, Benoît Salinier, Katherine K Coady, Alan Jones, Oliver Körner, Jessica LaRocca, Gregory Lemkine, Barbara Robin-Duchesne, Lennart Weltje, James R Wheeler, Laurent Lagadic
The Xenopus Eleutheroembryonic Thyroid Assay (XETA) was recently published as an OECD Test Guideline for detecting chemicals acting on the thyroid axis. However, the OECD validation did not cover all mechanisms that can potentially be detected by the XETA. This study was therefore initiated to investigate and consolidate the applicability domain of the XETA regarding the following mechanisms: thyroid hormone receptor (THR) agonism, sodium-iodide symporter (NIS) inhibition, thyroperoxidase (TPO) inhibition, deiodinase (DIO) inhibition, glucocorticoid receptor (GR) agonism, and uridine 5'-diphospho-glucuronosyltransferase (UDPGT) induction...
April 11, 2024: Regulatory Toxicology and Pharmacology: RTP