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https://www.readbyqxmd.com/read/28749296/bridging-gaps-between-zoo-and-wildlife-medicine-establishing-reference-intervals-for-free-ranging-african-lions-panthera-leo
#1
Heather M Broughton, Danny Govender, Purvance Shikwambana, Patrick Chappell, Anna Jolles
The International Species Information System has set forth an extensive database of reference intervals for zoologic species, allowing veterinarians and game park officials to distinguish normal health parameters from underlying disease processes in captive wildlife. However, several recent studies comparing reference values from captive and free-ranging animals have found significant variation between populations, necessitating the development of separate reference intervals in free-ranging wildlife to aid in the interpretation of health data...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749063/patients-as-rights-holders
#2
Johan Brännmark
Autonomy and consent have been central values in Western moral and political thought for centuries. One way of understanding the bioethical models that started to develop, especially in the 1970s, is that they were about the fusion of a long-standing professional ethics with the core values underpinning modern political institutions. That there was a need for this kind of fusion is difficult to dispute, especially since the provision of health care has in most developed countries become an ever more important concern of our political institutions, with governments playing a significant role in regulating and facilitating the provision of health care and in many countries even largely organizing it...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28749054/the-precision-medicine-nation
#3
Maya Sabatello, Paul S Appelbaum
The United States' ambitious Precision Medicine Initiative proposes to accelerate exponentially the adoption of precision medicine, an approach to health care that tailors disease diagnosis, treatment, and prevention to individual variability in genes, environment, and lifestyle. It aims to achieve this by creating a cohort of volunteers for precision medicine research, accelerating biomedical research innovation, and adopting policies geared toward patients' empowerment. As strategies to implement the PMI are formulated, critical consideration of the initiative's ethical and sociopolitical dimensions is needed...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28748978/degradable-polyesters-via-ring-opening-polymerization-of-functional-valerolactones-for-efficient-gene-delivery
#4
Ling Song, Ai-Xiang Ding, Ke-Xin Zhang, Bing Gong, Zhong-Lin Lu, Lan He
Degradable polymers as gene and drug carriers are emerging as one of the most promising types of materials in the biomedical and pharmaceutical areas. Herein, we report the synthesis of a series of block co-polyesters (B1-B6) and random co-polyesters (C1-C4) via ring-opening polymerization of tertiary amine-bearing valerolactone and alkylated valerolactone monomers. These polymers can completely inhibit the electrophoretic migrations of plasmid DNAs (pDNAs) at a w/w ratio of 2-6. The polyplexes of these polymers with pDNAs were steadily formed in a narrow range of sizes (75 to 220 nm) and could be effectively internalized into the cytoplasm...
July 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28748949/don-t-run-biomedical-science-as-a-business
#5
Michele Pagano
No abstract text is available yet for this article.
July 25, 2017: Nature
https://www.readbyqxmd.com/read/28748734/biochemical-alterations-induced-by-nickel-oxide-nanoparticles-in-female-wistar-albino-rats-after-acute-oral-exposure
#6
Naresh Dumala, Bhanuramya Mangalampalli, Kalyan Kamal Srinivasa Sarika, Paramjit Grover
CONTEXT: Nickel oxide (NiO) nanoparticles (NPs) with appropriate surface chemistry have been widely used for their potential new applications in biomedical industry. Increased usage of these NPs, enhances the chance of exposure of personnel involved in the work place. OBJECTIVE: This study was designed to assess the ability of NiO NPs to cause biochemical alterations post-acute oral exposure in female Wistar rats. MATERIALS AND METHODS: Rats were administered with 125, 250, and 500 mg/kg doses of NiO NPs for haematological, biochemical and histopathological studies...
July 27, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28748698/band-gap-engineering-of-titania-film-through-cobalt-regulation-for-oxidative-damage-of-bacteria-respiration-and-viability
#7
Jinhua Li, Jiaxing Wang, Donghui Wang, Geyong Guo, Kelvin Wai Kwok Yeung, Xianlong Zhang, Xuanyong Liu
Biomaterial-related bacterial infections cause patient suffering, mortality and extended periods of hospitalization, and impose a substantial burden on medical systems. In this context, understanding the interactions between nanomaterials and bacteria is clinically significant. Herein, TiO2-based heterojunctions including Co-TiO2, CoO-TiO2 and Co3O4-TiO2, were firstly designed by optimizing magnetron sputtering to establish a platform to explore the interactions between nanomaterials and bacteria. We found that the energy band bending and band gap narrowing were effectively promoted at the contact interface of the heterojunctions, which have the ability to induce abiotic reactive oxygen species formation...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748671/ti6al4v-laser-surface-preparation-and-functionalization-using-hydroxyapatite-for-biomedical-applications
#8
D Faria, C S Abreu, M Buciumeanu, N Dourado, O Carvalho, F S Silva, G Miranda
This work presents a novel texture design for implants surface functionalization, through the creation of line-shaped textures on Ti6Al4V surfaces and subsequent sintering of hydroxyapatite (HAp) powder into the designated locations. HAp-rich locations were designed to avoid HAp detachment during insertion, thus guaranteeing an effective osseointegration. This process starts by creating textured lines using a Nd:YAG laser, filling these lines with HAp powder and sintering HAp using a CO2 laser. The adhesion of HAp is known to be influenced by HAp sintering parameters, especially laser power and scanning speed and also by the textured lines manufacturing...
July 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28748520/advances-in-the-development-of-improved-animal-free-models-for-use-in-breast-cancer-biomedical-research
#9
REVIEW
Sophie Roberts, Valerie Speirs
Through translational research, the outcomes for women (and men) diagnosed with breast cancer have improved significantly, with now over 80% of women surviving for at least 5 years post-diagnosis. Much of this success has been translated from the bench to the bedside using laboratory models. Here, we outline the types of laboratory models that have helped achieve this and discuss new approaches as we move towards animal-free disease modelling.
July 26, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28748430/inicu-integrated-neonatal-care-unit-capturing-neonatal-journey-in-an-intelligent-data-way
#10
Harpreet Singh, Gautam Yadav, Raghuram Mallaiah, Preetha Joshi, Vinay Joshi, Ravneet Kaur, Suneyna Bansal, Samir K Brahmachari
Neonatal period represents first 28 days of life, which is the most vulnerable time for a child's survival especially for the preterm babies. High neonatal mortality is a prominent and persistent problem across the globe. Non-availability of trained staff and infrastructure are the major recognized hurdles in the quality care of these neonates. Hourly progress growth charts and reports are still maintained manually by nurses along with continuous calculation of drug dosage and nutrition as per the changing weight of the baby...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28748107/study-protocol-a-mixed-methods-feasibility-study-for-a-loaded-self-managed-exercise-programme-for-patellofemoral-pain
#11
Benjamin E Smith, Paul Hendrick, Marcus Bateman, Fiona Moffatt, Michael Skovdal Rathleff, James Selfe, Toby O Smith, Pip Logan
BACKGROUND: Patellofemoral pain (PFP) is one of the most common forms of knee pain in adults under the age of 40, with a prevalence of 23% in the general population. The long-term prognosis is poor, with only one third of people pain-free 1 year after diagnosis. The biomedical model of pain in relation to persistent PFP has recently been called into question. It has been suggested that interventions for chronic musculoskeletal conditions should consider alternative mechanisms of action, beyond muscles and joints...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28748089/the-role-of-nanotechnology-in-the-treatment-of-viral-infections
#12
REVIEW
Lavanya Singh, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender, Raveen Parboosing
Infectious diseases are the leading cause of mortality worldwide, with viruses in particular making global impact on healthcare and socioeconomic development. In addition, the rapid development of drug resistance to currently available therapies and adverse side effects due to prolonged use is a serious public health concern. The development of novel treatment strategies is therefore required. The interaction of nanostructures with microorganisms is fast-revolutionizing the biomedical field by offering advantages in both diagnostic and therapeutic applications...
July 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28747984/annual-tendency-of-research-papers-used-icr-mice-as-experimental-animals-in-biomedical-research-fields
#13
Ji Eun Kim, Jung Hoon Nam, Joon Young Cho, Kil Soo Kim, Dae Youn Hwang
Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research papers involving ICR mice in various biomedical fields has not been previously analyzed. In this study, we examined the numbers of papers that used ICR mice as experimental animals in the social science, natural science, engineering, medicine-pharmacy, marine agriculture-fishery, and art-kinesiology fields by analyzing big data...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747980/comparative-analysis-of-basal-locomotor-activity-related-metabolic-phenotypes-between-c57bl-6-mice-and-icr-mice-substrains-derived-from-three-different-sources
#14
Dong-Ju Hwang, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang, Joon Young Cho
Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish the metabolic phenotype of animal model to minimize spurious interpretations and ensure a level of accuracy and reliability adequate for experimental research. However, the metabolic phenotype-related analysis within rodent strains derived from different source is nonexistent, especially in C57BL/6Korl mice and Korl:ICR mice (a domestic mouse strain)...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747354/mentoring-interventions-for-underrepresented-scholars-in-biomedical-and-behavioral-sciences-effects-on-quality-of-mentoring-interactions-and-discussions
#15
Vivian Lewis, Camille A Martina, Michael P McDermott, Linda Chaudron, Paula M Trief, Jennifer G LaGuardia, Daryl Sharp, Steven R Goodman, Gene D Morse, Richard M Ryan
Mentors rarely receive education about the unique needs of underrepresented scholars in the biomedical and behavioral sciences. We hypothesized that mentor-training and peer-mentoring interventions for these scholars would enrich the perceived quality and breadth of discussions between mentor-protégé dyads (i.e., mentor-protégé pairs). Our multicenter, randomized study of 150 underrepresented scholar-mentor dyads compared: 1) mentor training, 2) protégé peer mentoring, 3) combined mentor training and peer mentoring, and 4) a control condition (i...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28747352/increasing-research-productivity-in-undergraduate-research-experiences-exploring-predictors-of-collaborative-faculty-student-publications
#16
Danielle X Morales, Sara E Grineski, Timothy W Collins
Little attention has been paid to understanding faculty-student productivity via undergraduate research from the faculty member's perspective. This study examines predictors of faculty-student publications resulting from mentored undergraduate research, including measures of faculty-student collaboration, faculty commitment to undergraduate students, and faculty characteristics. Generalized estimating equations were used to analyze data from 468 faculty members across 13 research-intensive institutions, collected by a cross-sectional survey in 2013/2014...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28747081/fabrication-characterization-and-in%C3%A2-vitro-study-of-zinc-substituted-hydroxyapatite-silk-fibroin-composite-coatings-on-titanium-for-biomedical-applications
#17
Zhenyu Zhong, Jun Ma
Zinc substituted hydroxyapatite/silk fibroin composite coatings were deposited on titanium substrates at room temperature by electrophoretic deposition. Microscopic characterization of the synthesized composite nanoparticles revealed that the particle size ranged 50-200 nm, which increased a little after zinc substitution. The obtained coatings maintained the phase of hydroxyapatite and they could induce fast apatite formation in simulated body fluid, indicating high bone activity. The cell culturing results showed that the biomimetic hydroxyapatite coatings could regulate adhesion, spreading, and proliferation of osteoblastic cells...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28746842/the-droso4schools-project-long-term-scientist-teacher-collaborations-to-promote-science-communication-and-education-in-schools
#18
REVIEW
Sanjai Patel, Sophie DeMaine, Joshua Heafield, Lynne Bianchi, Andreas Prokop
Science communication is becoming an increasingly important part of a scientist's remit, and engaging with primary and secondary schools is one frequently chosen strategy. Here we argue that engaging with schools will be more effective when engaging with teachers through structured participation and/or collaboration, in order to respond to the realities of school life in designing the strategies used by science communicators. For example, the Manchester Fly Facility advocates the fruit fly Drosophila as an important research strategy for the discovery processes in the biomedical sciences...
July 23, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28746392/design-characterization-and-experimental-validation-of-a-compact-flexible-pulsed-power-architecture-for-ex-vivo-platelet-activation
#19
Allen L Garner, Antonio Caiafa, Yan Jiang, Steve Klopman, Christine Morton, Andrew S Torres, Amanda M Loveless, V Bogdan Neculaes
Electric pulses can induce various changes in cell dynamics and properties depending upon pulse parameters; however, pulsed power generators for in vitro and ex vivo applications may have little to no flexibility in changing the pulse duration, rise- and fall-times, or pulse shape. We outline a compact pulsed power architecture that operates from hundreds of nanoseconds (with the potential for modification to tens of nanoseconds) to tens of microseconds by modifying a Marx topology via controlling switch sequences and voltages into each capacitor stage...
2017: PloS One
https://www.readbyqxmd.com/read/28746045/applicability-of-biotechnologically-produced-insect-silks
#20
Heike M Herold, Thomas Scheibel
Silks are structural proteins produced by arthropods. Besides the well-known cocoon silk, which is produced by larvae of the silk moth Bombyx mori to undergo metamorphosis inside their silken shelter (and which is also used for textile production by men since millennia), numerous further less known silk-producing animals exist. The ability to produce silk evolved multiple independent times during evolution, and the fact that silk was subject to convergent evolution gave rise to an abundant natural diversity of silk proteins...
July 26, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
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