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https://www.readbyqxmd.com/read/28107744/sensitive-detection-of-t4-polynucleotide-kinase-activity-based-on-multifunctional-magnetic-probes-and-polymerization-nicking-reactions-mediated-hyperbranched-rolling-circle-amplification
#1
Xia Li, Xiaowen Xu, Juan Song, Qingwang Xue, Chenzhong Li, Wei Jiang
T4 polynucleotide kinase (PNK) plays critical roles in regulating DNA phosphorylation modes during the repair of DNA lesions. The aberrant activity of T4 PNK has been proven to be associated with a variety of human pathologies. Sensitive detection of T4 PNK activity is critical to both clinical diagnosis and therapeutics. Herein, a background-eliminated fluorescence assay for sensitive detection of T4 PNK activity has been developed by multifunctional magnetic probes and polymerization nicking reactions mediated hyperbranched rolling circle amplification (HRCA)...
January 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28107743/high-sensitivity-four-layer-polymer-fiber-optic-evanescent-wave-sensor
#2
Xin Xin, Nianbing Zhong, Qiang Liao, Yanyan Cen, Ruohua Wu, Zhengkun Wang
We present a novel four-layer structure consisting of bottom, second, third, and surface layers in the sensing region, for a D-shaped step-index fiber-optic evanescent wave (FOEW) sensor. To reduce the background noise, the surface of the longitudinal section in the D-shaped region is coated with a light-absorbing film. We check the morphologies of the second and surface layers, examine the refractive indices (RIs) of the third and surface layers, and analyze the composition of the surface layer. We also investigate the effects of the thicknesses and RIs of the third and surface layers and the LA film on the light transmission and sensitivity of the FOEW sensors...
January 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28106954/biomedical-uses-for-2d-materials-beyond-graphene-current-advances-and-challenges-ahead
#3
Rajendra Kurapati, Kostas Kostarelos, Maurizio Prato, Alberto Bianco
No abstract text is available yet for this article.
January 2017: Advanced Materials
https://www.readbyqxmd.com/read/28106871/biomedical-research-awareness-day
#4
Logan France
No abstract text is available yet for this article.
January 20, 2017: Lab Animal
https://www.readbyqxmd.com/read/28106578/imia-educational-recommendations-and-nursing-informatics
#5
John Mantas, Arie Hasman
The updated version of the IMIA educational recommendations has given an adequate guidelines platform for developing educational programs in Biomedical and Health Informatics at all levels of education, vocational training, and distance learning. This chapter will provide a brief introduction of the recommendations pinpointing aspects for developing and assessing educational programs. We will provide a review of the existing feedback we have acquired during the IMIA site visits of accrediting educational programs at a worldwide level and discuss implementations issues...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28106389/orthogonal-luciferase-luciferin-pairs-for-bioluminescence-imaging
#6
Krysten A Jones, William B Porterfield, Colin M Rathbun, David C McCutcheon, Miranda A Paley, Jennifer A Prescher
Bioluminescence imaging with luciferase-luciferin pairs is widely used in biomedical research. Several luciferases have been identified in nature, and many have been adapted for tracking cells in whole animals. Unfortunately, the optimal luciferases for imaging in vivo utilize the same substrate, and therefore cannot easily differentiate multiple cell types in a single subject. To develop a broader set of distinguishable probes, we crafted custom luciferins that can be selectively processed by engineered luciferases...
January 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28106378/cell-selective-apoptosis-induced-by-polymorphic-alteration-of-self-assembled-silica-nano-webs
#7
Meysam Keshavarz, Bo Tan, Krishnan Venkatakrishnan
The biocompatibility of silicon-based nanomaterial makes it suitable for biophysical and biomedical applications. However, the application of silicon-based nanomaterials has been mainly restricted to nanoparticles (NPs) as a potential drug carrier and the extracellular matrix (ECM) as a platform for cell adhesion and proliferation. Here, we introduced silica NPs self-assembled into a 3D nano-web architecture that was shown to inherit the therapeutic and proliferative attributes of both NPs and ECMs. The self-assembled silica nano-web (SNW) has, therefore, not only shown targeted drug-like behavior in HeLa cells without the use of bio-markers but also has shown ECM characteristics...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106368/programmable-shape-recovery-process-of-water-responsive-shape-memory-polyvinyl-alcohol-by-wettability-contrast-strategy
#8
Zhiqiang Fang, Yudi Kuang, Panpan Zhou, Siyi Ming, Penghui Zhu, Yu Liu, Honglong Ning, Gang Chen
Water-responsive shape memory polymers (SMPs) are desirable for biomedical applications, but their limited shape recovery process is problematic. Herein, we demonstrate a shape-memory polyvinyl alcohol (SM-PVA) with programmable multi-step shape recovery processes in water via a wettability contrast strategy. A hexamethyldisilazane (HMDS)-treated SiO2 nanoparticle layer with varying loading weights was rationally deposited onto the surface of SM-PVA, aiming to create surface-wettability contrast. The varying wettability led to different water adsorption behaviors of SM-PVA that could be well described by the pseudo-first-order kinetic model...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106200/bright-conjugated-polymer-nanoparticles-containing-a-biodegradable-shell-produced-at-high-yields-and-with-tuneable-optical-properties-by-a-scalable-microfluidic-device
#9
T F Abelha, T W Phillips, J H Bannock, A M Nightingale, C A Dreiss, E Kemal, L Urbano, J C deMello, M Green, L A Dailey
This study compares the performance of a microfluidic technique and a conventional bulk method to manufacture conjugated polymer nanoparticles (CPNs) embedded within a biodegradable poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG5K-PLGA55K) matrix. The influence of PEG5K-PLGA55K and conjugated polymers cyano-substituted poly(p-phenylene vinylene) (CN-PPV) and poly(9,9-dioctylfluorene-2,1,3-benzothiadiazole) (F8BT) on the physicochemical properties of the CPNs was also evaluated. Both techniques enabled CPN production with high end product yields (∼70-95%)...
January 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28106145/cd1-and-cd1-porcine-blood-dendritic-cells-are-enriched-for-the-orthologues-of-the-two-major-mammalian-conventional-subsets
#10
Jane C Edwards, Helen E Everett, Miriam Pedrera, Helen Mokhtar, Emanuele Marchi, Ferran Soldevila, Daryan A Kaveh, Philip J Hogarth, Helen L Johns, Javier Nunez-Garcia, Falko Steinbach, Helen R Crooke, Simon P Graham
Conventional dendritic cells (cDC) are professional antigen-presenting cells that induce immune activation or tolerance. Two functionally specialised populations, termed cDC1 and cDC2, have been described in humans, mice, ruminants and recently in pigs. Pigs are an important biomedical model species and a key source of animal protein; therefore further understanding of their immune system will help underpin the development of disease prevention strategies. To characterise cDC populations in porcine blood, DC were enriched from PBMC by CD14 depletion and CD172a enrichment then stained with lineage mAbs (Lin; CD3, CD8α, CD14 and CD21) and mAbs specific for CD172a, CD1 and CD4...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105473/recent-applications-of-the-combination-of-mesoporous-silica-nanoparticles-with-nucleic-acids-development-of-bioresponsive-devices-carriers-and-sensors
#11
REVIEW
Rafael R Castillo, Alejandro Baeza, María Vallet-Regí
The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Such is the importance of these gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Currently, there could be found in the literature a practically intractable number of examples reporting the use of combination of nanoparticles with nucleic acids, so boundaries are demanded. Following this premise, this review will only cover the most recent and powerful strategies developed to exploit the possibilities of nucleic acids as biotechnological materials when in combination with mesoporous silica nanoparticles...
January 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28105392/in-vivo-long-term-biodistribution-excretion-and-toxicology-of-pegylated-transition-metal-dichalcogenides-ms2-m-mo-w-ti-nanosheets
#12
Jiali Hao, Guosheng Song, Teng Liu, Xuan Yi, Kai Yang, Liang Cheng, Zhuang Liu
With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to carefully study the in vivo biodistribution, excretion, and toxicology profiles of different TMDCs, and hopefully to identify the most promising type of TMDCs with low toxicity and fast excretion for further biomedical applications. Herein, the in vivo behaviors of three representative TMDCs including molybdenum dichalcogenides (MoS2), tungsten dichalcogenides (WS2), and titanium dichalcogenides (TiS2) nanosheets are systematically investigated...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28105391/one-dimensional-tio2-nanotube-photocatalysts-for-solar-water-splitting
#13
REVIEW
Mingzheng Ge, Qingsong Li, Chunyan Cao, Jianying Huang, Shuhui Li, Songnan Zhang, Zhong Chen, Keqin Zhang, Salem S Al-Deyab, Yuekun Lai
Hydrogen production from water splitting by photo/photoelectron-catalytic process is a promising route to solve both fossil fuel depletion and environmental pollution at the same time. Titanium dioxide (TiO2) nanotubes have attracted much interest due to their large specific surface area and highly ordered structure, which has led to promising potential applications in photocatalytic degradation, photoreduction of CO2, water splitting, supercapacitors, dye-sensitized solar cells, lithium-ion batteries and biomedical devices...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28104900/extremozymes-a-potential-source-for-industrial-applications
#14
REVIEW
Kelly Dumorné, David Camacho Córdova, Marcia Astorga-Eló, Prabhaharan Renganathan
Extremophilic microorganisms have established a diversity of molecular strategies in order to survive in extreme conditions. Biocatalysts isolated by these organisms are termed extremozymes, possess extraordinary properties are salt allowance thermostability and cold adaptivity. Extremozymes are very resistant in extreme conditions due to their great solidity and they propose new opportunities for biocatalysis and biotransformations, also for the development of the economy and new line of research through their application...
January 20, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28104841/human-tissues-in-a-dish-the-research-and-ethical-implications-of-organoid-technology
#15
REVIEW
Annelien L Bredenoord, Hans Clevers, Juergen A Knoblich
The ability to generate human tissues in vitro from stem cells has raised enormous expectations among the biomedical research community, patients, and the general public. These organoids enable studies of normal development and disease and allow the testing of compounds directly on human tissue. Organoids hold the promise to influence the entire innovation cycle in biomedical research. They affect fields that have been subjects of intense ethical debate, ranging from animal experiments and the use of embryonic or fetal human tissues to precision medicine, organoid transplantation, and gene therapy...
January 20, 2017: Science
https://www.readbyqxmd.com/read/28104626/deformational-plagiocephaly-in-normal-infants-a-systematic-review-of-causes-and-hypotheses
#16
Freia De Bock, Volker Braun, Herbert Renz-Polster
BACKGROUND: Deformational plagiocephaly (DP) is one of the most prevalent abnormal findings in infants and a frequent reason for parents to seek paediatric advice. OBJECTIVE: To systematically review the literature and identify evidence and hypotheses on the aetiology and determinants of DP in otherwise healthy infants. DESIGN: Systematic keyword search in all major biomedical databases to identify peer-reviewed publications reporting (a) empirical research or (b) hypotheses on the aetiology of DP in healthy, term infants...
January 19, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28104510/mechanochemically-synthesized-ag-based-nanohybrids-with-unprecedented-low-toxicity-in-biomedical-applications
#17
Rick A D Arancon, Alina M Balu, Antonio A Romero, Manuel Ojeda, Mercedes Gomez, Jordi Blanco, Jose L Domingo, Rafael Luque
A simple and innovative mechanochemical approach was employed to synthesize Ag-polysaccharide nanohybrid materials that were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized Ag nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SY5Y as compared to similarly reported Ag nanomaterials due to the stability and low release of Ag(+) and high biocompatibility of the nanohybrids.
January 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28104188/maternal-multiple-micronutrient-supplementation-and-other-biomedical-and-socioenvironmental-influences-on-children-s-cognition-at-age-9-12-years-in-indonesia-follow-up-of-the-summit-randomised-trial
#18
Elizabeth L Prado, Susy K Sebayang, Mandri Apriatni, Siti R Adawiyah, Nina Hidayati, Ayuniarti Islamiyah, Sudirman Siddiq, Benyamin Harefa, Jarrad Lum, Katherine J Alcock, Michael T Ullman, Husni Muadz, Anuraj H Shankar
BACKGROUND: Brain and cognitive development during the first 1000 days from conception are affected by multiple biomedical and socioenvironmental determinants including nutrition, health, nurturing, and stimulation. An improved understanding of the long-term influence of these factors is needed to prioritise public health investments to optimise human development. METHODS: We did a follow-up study of the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT), a double-blind, cluster-randomised trial of maternal supplementation with multiple micronutrients (MMN) or iron and folic acid (IFA) in Indonesia...
February 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28103663/biological-photothermal-nanodots-based-on-self-assembly-of-peptide-porphyrin-conjugates-for-antitumor-therapy
#19
Qianli Zou, Manzar Abbas, Luyang Zhao, Shukun Li, Guizhi Shen, Xuehai Yan
Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots...
January 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28103580/biodegradable-and-biocompatible-high-elastic-chitosan-scaffold-is-cell-friendly-both-in-vitro-and-in-vivo
#20
Yichuan Pang, An Qin, Xianfeng Lin, Lin Yang, Qiang Wang, Zhengke Wang, Zhi Shan, Shengyun Li, Jiying Wang, Shunwu Fan, Qiaoling Hu
Biodegradable and biocompatible macromolecule chitosan has been favored for a variety of clinical applications. We reported herein the fabrication of a novel chitosan scaffold with high elasticity. This scaffold can be easily compressed and thus enable the insertion of such scaffold into surgical lesions during minimal invasive surgeries. In addition, this novel scaffold can restore its shape when released. We evidenced that this high elastic scaffold has better biocompatibility than traditional chitosan scaffold...
January 17, 2017: Oncotarget
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