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https://www.readbyqxmd.com/read/28930638/use-of-telehealth-for-health-care-of-indigenous-peoples-with-chronic-conditions-a-systematic-review
#1
Sarah Fraser, Tamara Mackean, Julian Grant, Kate Hunter, Kurt Towers, Rebecca Ivers
INTRODUCTION: Telehealth may be a cost effective modality in healthcare delivery, but how well used or how appropriate it is for the care of Indigenous peoples is unclear. This review examines the evidence for telehealth in facilitating chronic conditions management with Indigenous peoples. METHODS: Databases were systematically searched for qualitative or quantitative primary research studies that investigated telehealth use for chronic conditions management with Indigenous peoples worldwide...
July 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28930545/classification-of-retinal-diseases-based-on-oct-images
#2
Nabila Eladawi, Mohammed M Elmogy, Mohammed Ghazal, Omar Helmy, Ahmed Aboelfetouh, Alaa Riad, Shlomit Schaal, Ayman El-Baz
Optical Coherence Topography (OCT) is an emerging biomedical imaging technology that offers non-invasive real-time, high-resolution imaging of highly scattering tissues. It is widely used in ophthalmology to perform diagnostic imaging on the structure of the anterior eye and the retina. Clinical studies are carried out to assess the application of OCT for some retinal diseases. OCT can provide means for early detection for various types of diseases because morphological changes often occur before the physical symptoms of these diseases...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930488/the-impact-of-repeated-freeze-thaw-cycles-on-the-quality-of-biomolecules-in-four-different-tissues
#3
Xiaoli Ji, Min Wang, Lingling Li, Fang Chen, Yanyang Zhang, Qian Li, Junmei Zhou
High-quality biosamples are valuable resources for biomedical research. However, some tissues are stored without being sectioned into small aliquots and have to undergo repeated freeze-thaw cycles throughout prolonged experimentation. Little is known regarding the effects of repeated freeze-thaw cycles on the quality of biomolecules in tissues. The aim of this study was to evaluate the impact of repeated freeze-thaw (at room temperature or on ice) cycles on biomolecules and gene expression in four different types of tissues...
September 20, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28930338/biomedical-nanomotors-efficient-glucose-mediated-insulin-release
#4
Paula Díez, Berta Esteban-Fernández de Ávila, Doris E Ramírez-Herrera, Reynaldo Villalonga, Joseph Wang
We report herein the design of an autonomous glucose-responsive smart nanomachine for insulin (In) delivery based on ultrasound (US)-propelled nanomotors combined with an enzyme-based sensing-effector unit. Gold nanowire (AuNW) motors have been coupled with a mesoporous silica (MS) segment, which was gated with pH-responsive phenylboronic acid (PBA)-glucose oxidase (GOx) supramolecular nanovalves responsible for the insulin release. Glucose-induced protonation of the PBA groups triggers the opening of the pH-driven gate and uncapping of the insulin-loaded nanovalves...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28930330/chemistry-and-engineering-of-cyclodextrins-for-molecular-imaging
#5
REVIEW
Wing-Fu Lai, Andrey L Rogach, Wing-Tak Wong
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides bearing a basket-shaped topology with an "inner-outer" amphiphilic character. The abundance of hydroxyl groups enables CDs to be functionalized with multiple targeting ligands and imaging elements. The imaging time, and the payload of different imaging elements, can be tuned by taking advantage of the commercial availability of CDs with different sizes of the cavity. This review aims to offer an outlook of the chemistry and engineering of CDs for the development of molecular probes...
September 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28930158/a-method-for-medical-diagnosis-based-on-optical-fluence-rate-distribution-at-tissue-surface
#6
Omnia Hamdy, Jala El-Azab, Tarek A Al-Saeed, Mahmoud F Hassan, Nahed H Solouma
Optical differentiation is a promising tool in biomedical diagnosis mainly because of its safety. The optical parameters' values of biological tissues differ according to the histopathology of the tissue and hence could be used for differentiation. The optical fluence rate distribution on tissue boundaries depends on the optical parameters. So, providing image displays of such distributions can provide a visual means of biomedical diagnosis. In this work, an experimental setup was implemented to measure the spatially-resolved steady state diffuse reflectance and transmittance of native and coagulated chicken liver and native and boiled breast chicken skin at 635 and 808 nm wavelengths laser irradiation...
September 20, 2017: Materials
https://www.readbyqxmd.com/read/28929971/medisyn-uncertainty-aware-visualization-of-multiple-biomedical-datasets-to-support-drug-treatment-selection
#7
Chen He, Luana Micallef, Zia-Ur-Rehman Tanoli, Samuel Kaski, Tero Aittokallio, Giulio Jacucci
BACKGROUND: Dispersed biomedical databases limit user exploration to generate structured knowledge. Linked Data unifies data structures and makes the dispersed data easy to search across resources, but it lacks supporting human cognition to achieve insights. In addition, potential errors in the data are difficult to detect in their free formats. Devising a visualization that synthesizes multiple sources in such a way that links between data sources are transparent, and uncertainties, such as data conflicts, are salient is challenging...
September 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28929643/demons-registration-for-in-vivo-and-deformable-laser-scanning-confocal-endomicroscopy
#8
Wei-Ming Chiew, Feng Lin, Hock Soon Seah
A critical effect found in noninvasive in vivo endomicroscopic imaging modalities is image distortions due to sporadic movement exhibited by living organisms. In three-dimensional confocal imaging, this effect results in a dataset that is tilted across deeper slices. Apart from that, the sequential flow of the imaging-processing pipeline restricts real-time adjustments due to the unavailability of information obtainable only from subsequent stages. To solve these problems, we propose an approach to render Demons-registered datasets as they are being captured, focusing on the coupling between registration and visualization...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28929152/size-dependent-targeted-delivery-of-gold-nanoparticles-modified-with-the-il-6r-specific-aptamer-air-3a-to-il-6r-carrying-cells
#9
Lisa Prisner, Nadine Bohn, Ulrich Hahn, Alf Mews
The delivery of gold nanoparticles (AuNPs) to specific cells strongly depends on the properties e.g. the size of the particles and is of great interest for a large variety of biomedical applications. Here we investigated the size dependence of the receptor-ligand mediated AuNP delivery to cells by comparing very small "molecular" Au-clusters of only 2 nm to larger 7 nm and 36 nm AuNPs with a distinct surface plasmon resonance. Since the molecular weight in this range changes by almost three orders of magnitude, we show how the amount of gold relates to the number of delivered AuNPs...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28928662/toxicity-of-nanoparticles-on-the-reproductive-system-in-animal-models-a-review
#10
REVIEW
Rahim Dad Brohi, Li Wang, Hira Sajjad Talpur, Di Wu, Farhan Anwar Khan, Dinesh Bhattarai, Zia-Ur Rehman, F Farmanullah, Li-Jun Huo
In the last two decades, nanotechnologies demonstrated various applications in different fields, including detection, sensing, catalysis, electronics, and biomedical sciences. However, public concerns regarding the well-being of human may hinder the wide utilization of this promising innovation. Although, humans are exposed to airborne nanosized particles from an early age, exposure to such particles has risen dramatically within the last century due to anthropogenic sources of nanoparticles. The wide application of nanomaterials in industry, consumer products, and medicine has raised concerns regarding the potential toxicity of nanoparticles in humans...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28928494/systematic-review-and-meta-analyses-of-the-difference-between-the-spinal-level-of-the-palpated-and-imaged-iliac-crests
#11
Robert Cooperstein, Felisha Truong
OBJECTIVE: The purpose of this study was to undertake a systematic review of the literature to determine and compare, for patient sub-groups, the spinal level of the iliac crests as commonly measured through manual palpation and radiographic imaging procedures. METHODS: Relevant citations were retrieved by searching the PubMed, ICL, CINAHL, AMED, Osteopathic Research Web, OstMed, and MANTIS biomedical databases, and included articles were rated for quality. Search terms included Tuffier*, intercristal line, intercrestal line, Jacoby's line, lumbar spine, lumbar landmark, pelvic landmark, palpation, and TL (Tuffier's Line)...
August 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28928444/immortalized-n-tert-keratinocytes-as-an-alternative-cell-source-in-3d-human-epidermal-models
#12
Jos P H Smits, Hanna Niehues, Gijs Rikken, Ivonne M J J van Vlijmen-Willems, Guillaume W H J F van de Zande, Patrick L J M Zeeuwen, Joost Schalkwijk, Ellen H van den Bogaard
The strong societal urge to reduce the use of experimental animals, and the biological differences between rodent and human skin, have led to the development of alternative models for healthy and diseased human skin. However, the limited availability of primary keratinocytes to generate such models hampers large-scale implementation of skin models in biomedical, toxicological, and pharmaceutical research. Immortalized cell lines may overcome these issues, however, few immortalized human keratinocyte cell lines are available and most do not form a fully stratified epithelium...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928426/cyanobacterial-sfp-type-phosphopantetheinyl-transferases-functionalize-carrier-proteins-of-diverse-biosynthetic-pathways
#13
Guang Yang, Yi Zhang, Nicholas K Lee, Monica A Cozad, Sara E Kearney, Hendrik Luesch, Yousong Ding
Cyanobacteria produce structurally and functionally diverse polyketides, nonribosomal peptides and their hybrids. Sfp-type phosphopantetheinyl transferases (PPTases) are essential to the production of these compounds via functionalizing carrier proteins (CPs) of biosynthetic megaenzymes. However, cyanobacterial Sfp-type PPTases remain poorly characterized, posing a significant barrier to the exploitation of cyanobacteria for biotechnological and biomedical applications. Herein, we describe the detailed characterization of multiple cyanobacterial Sfp-type PPTases that were rationally selected...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928344/knowledge-of-scientific-misconduct-in-publication-among-medical-students
#14
Syed Muhammad Mubeen, Rabia Ghayas, Syed Hasan Adil Rizvi, Sohaib Ahmed Khan
BACKGROUND: Publication is a central element in research dissemination and scientific misconduct in publication is relatively ignored in biomedical research. This study is to assess the knowledge of scientific misconduct in publication among private and public sector medical students. METHODS: A questionnaire-based cross-sectional study was carried in four (two public and two private) medical colleges of Karachi in 2015. After ethical approval, data were collected through convenient sampling and analyzed in SPSS 16...
May 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28928279/metabolism-in-time-and-space-exploring-the-frontier-of-developmental-biology
#15
REVIEW
Alena Krejci, Jason M Tennessen
Despite the fact that metabolic studies played a prominent role in the early history of developmental biology research, the field of developmental metabolism was largely ignored following the advent of modern molecular biology. Metabolism, however, has recently re-emerged as a focal point of biomedical studies and, as a result, developmental biologists are once again exploring the chemical and energetic forces that shape growth, development and maturation. In May 2017, a diverse group of scientists assembled at the EMBO/EMBL Symposium 'Metabolism in Time and Space' to discuss how metabolism influences cellular and developmental processes...
September 15, 2017: Development
https://www.readbyqxmd.com/read/28928067/silk-fibres-grafted-with-2-hydroxyethyl-methacrylate-hema-and-4-hydroxybutyl-acrylate-hba-for-biomedical-applications
#16
Paola Taddei, Michele Di Foggia, Simona Martinotti, Elia Ranzato, Irene Carmagnola, Valeria Chiono, Masuhiro Tsukada
Silk fibroin may be chemically modified by grafting, with the purpose of improving its properties according to the desired function. In this study, silk fabrics from Bombyx mori silk fibres were grafted with 2-hydroxyethyl methacrylate (HEMA), as well as a binary mixture of HEMA and 4-hydroxybutyl acrylate (HBA). The samples were then electrospun from trifluoroacetic acid and treated with aqueous methanol. The % weight gains ascribable to HEMA and HBA were successfully determined through Raman spectroscopy...
September 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28928056/-vaccine-hesitancy-discourse-analysis-of-parents-who-have-not-fully-or-partially-vaccinated-their-children
#17
Maite Cruz Piqueras, Ainhoa Rodríguez García de Cortazar, Joaquín Hortal Carmona, Javier Padilla Bernáldez
OBJECTIVE: To analyse and understand vaccination hesitancy discourses, particularly those of people who have decided not to vaccinate their sons and daughters. METHODS: Qualitative study of five individual interviews and two focus groups with people who chose not to vaccinate their children in the province of Granada (Spain). RESULTS: Mothers and fathers manifest a system of health beliefs different to the biomedical paradigm. From an ethical point of view, they justify their position based on the right to autonomy and responsibility for their decisions...
September 16, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28927728/cryopreservation-of-human-whole-blood-allows-immunophenotyping-by-flow-cytometry-up-to-30days-after-cell-isolation
#18
R Madelaine Paredes, Douglas K Tadaki, Amanda Sooter, Fabia Gamboni, C D R Forest Sheppard
Immunophenotyping of whole blood (WB) by flow cytometry (FC) is used clinically to assess a patient's immune status and also in biomedical research. Current protocols recommend storage of immunolabeled samples at 4°C with FC analysis to be completed within seven days. This data acquisition window can be extended to up to one year post-labeling, but this requires cryopreservation of the samples at ultra-low temperatures (≤-80°C or in liquid nitrogen). In this study we optimized a standardized cryopreservation protocol to enable preservation of immunolabeled, human WB samples at -20°C for FC and tested its effectiveness after 0, 5, 15 or 30days...
September 16, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28927621/in-vitro-degradation-and-possible-hydrolytic-mechanism-of-phbv-nanocomposites-by-incorporating-cellulose-nanocrystal-zno-nanohybrids
#19
Somia Yassin Hussain Abdalkarim, Hou-Yong Yu, Mei-Li Song, Ying Zhou, Juming Yao, Qing-Qing Ni
Fabrication and characterization of bbiodegradable nanocomposites based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) matrix reinforced with cellulose nanocrystal (CNC)-ZnO nanohybrids via simple solution casting for possible use as antibacterial biomedical materials is reported. The obtained nanocomposites exhibited an excellent antibacterial ratio of 95.2-100% for both types of bacteria namely S. aureus and E. coli and showed 9-15% degradation after one week. The addition of CNC-ZnO showed a positive effect on hydrophilicity and barrier properties...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28927589/molecular-dynamics-of-carrageenan-composites-reinforced-with-cloisite-na-montmorillonite-nanoclay
#20
M J Sanchis, M Carsí, M Culebras, C M Gómez, S Rodriguez, F G Torres
Nanocomposites comprising biodegradable carrageenan and glycerol (KCg) as the host polymer, with different contents of natural montmorillonite (MMT) as filler, were prepared by a solution casting process. Different techniques have been used to determine the interaction/behavior among the different components of the samples such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscope (TEM) and, mainly, Dielectric relaxation spectroscopy (DRS). FTIR indicates hydrogen interaction between carrageenan matrix and silicate that is confirmed by the XRD data indicating some kind of carrageenan intercalation between the MMT layers...
November 15, 2017: Carbohydrate Polymers
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