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Azam Sargazi, Fereshteh Shiri, Sheida Keikha, Mostafa Heidari Majd
Hyaluronic acid (HA) is increasingly investigated for biomedical applications such as regenerative medicine, aesthetic medicine, and drug delivery. Accordingly, conjugation of HA to PEGylated MNPs could increase the active targeting ability of nano-drug carriers toward CD44 receptors and be useful in a clinical setting such as drug delivery. So, we chemically conjugated mitoxantrone (MTX) to HA-PEGylated MNPs to use concurrent advantages such as prolong the circulation time, decrease the side effects and delivery toward special tumor cells...
July 11, 2018: Colloids and Surfaces. B, Biointerfaces
Ilona Olędzka, Piotr Kowalski, Alina Plenis, Natalia Miękus, Niels Grabow, Thomas Eickner, Tomasz Bączek
Simultaneous electrokinetic and hydrodynamic injection (SEHI) of rapamycin (sirolimus) with off-line and on-line sample pre-concentration techniques and using micellar electrokinetic chromatography (MEKC) has been studied. Compared to conventional hydrodynamic injection, a 168-fold improvement in the signal was obtained with a combination of SEHI and field enhanced sample injection (FESI) in conjunction with a sweeping technique called sequential stacking featuring sweeping. However, the coupling of the developed electrophoretic method and solid-phase microextraction (SPME) allowed the signal intensity to increase more than 231 times...
July 19, 2018: Electrophoresis
Shamkumar P Deshmukh, Sajid B Mullani, Valmiki B Koli, Satish M Patil, Promod J Kasabe, Padma B Dandge, Sachin A Pawar, Sagar D Delekar
Supported silver nanoparticles (Ag NPs) were prepared by chemical reduction method with a sol-gel method. The structural, morphology and interconnectivity of Ag/TiO2 nanocomposites (NCs) were analyzed using different instrumental techniques. Transmission electron microscopy reveals the Ag NPs have uniformly distributed and anchored on the surface of TiO2 . The reduction of electron-hole recombination was measured by Photoluminescence measurements lead, to an increased photocatalytic inactivation of bacteria...
July 19, 2018: Photochemistry and Photobiology
Nadia Corp, Joanne L Jordan, Peter R Croft
BACKGROUND: Complementary and alternative medicine (CAM) is very popular with patients frequently combining it with orthodox health care. The high prevalence of CAM use and satisfaction with CAM reported by patients directly challenges an orthodox system that can only approve such use if it results from the application of biomedical concepts and science. Studies highlighting this as a cultural, sociological and historical phenomenon emphasise the value of choice for consumers of health care...
2018: PloS One
Kathrine Meyers, Yumeng Wu, Atrina Brill, Theodorus Sandfort, Sarit A Golub
BACKGROUND: Phase III trials of long-acting injectable (LAI) PrEP, currently underway, have great potential for expanding the menu of HIV prevention options. Imagining a future in which multiple PrEP modalities are available to potential users of biomedical HIV prevention, we investigated which factors might help direct a patient-physician shared-decision making process to optimize the choice of biomedical HIV prevention method. METHODS: Participants (n = 105; ages 19-63; 46...
2018: PloS One
Carl C L Schuurmans, Anna Abbadessa, Mikkel A Bengtson, Galja Pletikapic, Huseyin Burak Eral, Gijsje Koenderink, Rosalinde Masereeuw, Wim E Hennink, Tina Vermonden
Glycosaminoglycans (GAGs) are of interest for biomedical applications because of their ability to retain proteins (e.g. growth factors) involved in cell-to-cell signaling processes. In this study, the potential of GAG-based microgels for protein delivery and their protein release kinetics upon encapsulation in hydrogel scaffolds were investigated. Monodisperse hyaluronic acid methacrylate (HAMA) and chondroitin sulfate methacrylate (CSMA) micro-hydrogel spheres (diameters 500-700 μm), were used to study the absorption of a cationic model protein (lysozyme), microgel (de)swelling, intra-gel lysozyme distribution and its diffusion coefficient in the microgels dispersed in buffers (pH 7...
July 19, 2018: Soft Matter
Lian-Hua Fu, Chao Qi, Jing Lin, Peng Huang
Glucose oxidase (GOx) is an endogenous oxido-reductase that is widely distributed in living organisms. Over recent years, GOx has attracted increasing interest in the biomedical field due to its inherent biocompatibility, non-toxicity, and unique catalysis against β-d-glucose. GOx efficiently catalyzes the oxidization of glucose into gluconic acid and hydrogen peroxide (H2O2), which can be employed by various biosensors for the detection of cancer biomarkers. Various cancer therapeutic strategies have also been developed based on the catalytic chemistry of GOx: (1) the consumption of glucose provides an alternative strategy for cancer-starvation therapy; (2) the consumption of oxygen increases tumor hypoxia, which can be harnessed for hypoxia-activated therapy; (3) the generation of gluconic acid enhances the acidity of the tumor microenvironment, which can trigger pH-responsive drug release; (4) the generation of H2O2 increases the levels of tumor oxidative stress, and the H2O2 can be converted into toxic hydroxyl radicals that can kill cancer cells upon exposure to light irradiation or via the Fenton reaction...
July 19, 2018: Chemical Society Reviews
Pranav Tiwari, Navpreet Kaur, Vinay Sharma, Shaikh M Mobin
The direct exfoliation of graphite (Gr) is highly desirable and feasible compared to conventional processes owing to its non-oxidative, facile and controlled synthesis conditions. Herein, gelatin (gel), a hydrolysed form of collagen, was used as an exfoliant to directly exfoliate Gr. The main advantages of exploring gel as an exfoliant is its easy availability, low cost and high biocompatibility, which alleviate the drawbacks of previous exfoliation methods. The effect of the exfoliation parameters such as temperature, ratio of interacting species and pH of the solution offers a high yield of graphene (G) with the added advantages of good solubility, easy dispersibility and high stability...
July 19, 2018: Physical Chemistry Chemical Physics: PCCP
Qi Tang, Yuanping Wang, Kuangyi Li
BACKGROUND: Chronic heart failure (CHF), not only a severe personal healthy problem but also a social financial burden, has become a global health concern. Zhenwu decoction (ZWD) has been widely adopted to clinical practice for patients with CHF. It is necessary to update the researches to reevaluate the efficacy and safety of ZWD to provide the up-to-date evidence for CHF management. Therefore, we provide a protocol of systematic review regarding ZWD for CHF. METHODS: The aim of this study was to retrieve papers on the topic of ZWD treatment for CHF in the electrical databases, including PubMed, Cochrane Library, EMBASE, Chinese Biomedical database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang database, and Chinese Science and Technology Periodical database (VIP)...
July 2018: Medicine (Baltimore)
Liansheng Gao, Weilin Xu, Tao Li, Jingwei Zheng, Gao Chen
OBJECTIVES: Distinguishing glioma recurrence from the necrosis after radiation therapy and/or chemotherapy is a crucial clinical issue, for the different diagnosis will lead to divergent treatments. The accurate judgment is barely achieved by conventional imaging methods. We therefore assume it is of need to exert a meta-analysis to evaluate the diagnostic accuracy of 11C-choline positron emission tomography (PET), to achieve this goal. MATERIAL AND METHODS: We searched the PubMed, Embase, and Chinese Biomedical databases comprehensively to select eligible studies and assessed the quality of each article included (up to May 31, 2018)...
July 2018: Medicine (Baltimore)
Xinyu Hu, Shijiao Cheng, Yuehui Yin, Lin Ning, Liquan Xiang, Yinpin Zhou
BACKGROUND: Supplemental oxygen has been commonly used in the cases of acute coronary syndrome (ACS); however, recent evidence suggests that high-concentration oxygen supplementation and hyperbaric oxygen in ACS patients are associated with adverse cardiovascular effects. OBJECTIVE: The purpose of this article is to systematically review the role of supplemental oxygen therapy in normoxemic patients with ACS. METHODS: A search for randomized controlled trials before November 2017 in biomedical databases was performed, and a total of 6 eligible studies with 7508 participants were identified...
July 18, 2018: Journal of Cardiovascular Nursing
Kristianna G Pettibone, David M Balshaw, Caroline Dilworth, Christina H Drew, Janet E Hall, Michelle Heacock, Alfonso R Latoni, Kimberly A McAllister, Liam R O'Fallon, Claudia Thompson, Nigel J Walker, Mary S Wolfe, Demia S Wright, Gwen W Collman
The National Institute of Environmental Health Sciences (NIEHS) introduces a new translational research framework that builds upon previous biomedical models to create a more comprehensive and integrated environmental health paradigm. The framework was developed as a graphical construct that illustrates the complexity of designing, implementing, and tracking translational research in environmental health. We conceptualize translational research as a series of concentric rings and nodes, defining "translation" as movement either from one ring to another or between nodes on a ring...
July 2018: Environmental Health Perspectives
Chandkiram Gautam, Dibyendu Chakravarty, Amarendra Gautam, Chandra Sekhar Tiwary, Cristiano Francisco Woellner, Vijay Kumar Mishra, Naseer Ahmad, Sehmus Ozden, Sujin Jose, Santoshkumar Biradar, Robert Vajtai, Ritu Trivedi, Douglas S Galvao, Pulickel M Ajayan
Recent advances and demands in biomedical applications drive a large amount of research to synthesize easily scalable low-density, high-strength, and wear-resistant biomaterials. The chemical inertness with low density combined with high strength makes h-BN one of the promising materials for such application. In this work, three-dimensional hexagonal boron nitride (h-BN) interconnected with boron trioxide (B2 O3 ) was prepared by easily scalable and energy efficient spark plasma sintering (SPS) process. The composite structure shows significant densification (1...
June 30, 2018: ACS Omega
Junjira Tanum, Jiwoong Heo, Jinkee Hong
Biomacromolecule loading is the popular research in the biomedical field. To control the loading amount and releasing profile, various materials and fabrication techniques were developed. In this study, layer-by-layer assembly of multilayer films between collagen (Col) and graphene oxide (GO) was used to control the release of the loading molecule. By mixing GO into the system, ovalbumin (OVA) can be spontaneously adsorbed onto the GO sheet (denoted as GO/OVA) via the hydrophobic interaction. Two kinds of multilayer films (Col/GO/OVA and Col/GO/OVA) were fabricated...
May 31, 2018: ACS Omega
Jianchuan Wen, Jinrong Yao, Xin Chen, Zhengzhong Shao
Silk fibroin (SF) has shown enormous potentials in various fields; however, application of SF in emulsion technology is quite limited. Here, we use SF as a self-emulsifier to form an oil-in-water (O/W) emulsion by emulsifying 1-butanol in SF aqueous solution. This showed that SF possessed strong surface activity to stabilize the O/W emulsion without the need for any other surface-active agent until its solidification because of 1-butanol-induced conformational transition of SF to β-sheet. After freezing the preformed emulsions at -20 °C, robust three-dimensional porous SF scaffolds were prepared without the need for any further post-treatment...
March 31, 2018: ACS Omega
Vijay Bhooshan Kumar, Michal Marcus, Ze'ev Porat, Lior Shani, Yosef Yeshurun, Israel Felner, Orit Shefi, Aharon Gedanken
In this work, we describe a low-cost, two-step synthesis of composites of nitrogen-doped carbon quantum dots (NCDs) with γ-Fe2 O3 (NCDs/γ-Fe2 O3 ), which is based on a hydrothermal cum co-precipitation method. The product is a fine powder of particles having an average diameter of 9 ± 3 nm. The physical and chemical properties of NCDs/γ-Fe2 O3 were studied, as well as the superconducting quantum interference device and Mossbauer analysis of the magnetic properties of these nanocomposites. The interaction of NCDs/γ-Fe2 O3 nanocomposites with neuron-like cells was examined, showing efficient uptake and low toxicity...
February 28, 2018: ACS Omega
Yung-Chieh Chan, Ming-Hsien Chan, Chieh-Wei Chen, Ru-Shi Liu, Michael Hsiao, Din Ping Tsai
The matrix metalloproteinases (MMPs) are well-known mediators that are activated in tumor progression. MMP2 is a kind of gelatinase in extracellular matrix remodeling and cancer metastasis processes. MMP2 secretion increased in many types of cancer diseases, and its abnormal expression is associated with a poor prognosis. We fabricated a nanocomposite that sensed MMP2 expression by a red and blue light change. This nanocomposite consisted of an upconversion nanoparticle (UCNP), MMP2-sensitive peptide, and CuInS2 /ZnS quantum dot (CIS/ZnS QD)...
February 28, 2018: ACS Omega
Changfen Bi, Yulu Liang, Lijin Shen, Shanshan Tian, Kai Zhang, Yiliang Li, Xiwen He, Langxing Chen, Yukui Zhang
Efficient enrichment glycoproteins/glycopeptides from complex biological solutions are very important in the biomedical sciences, in particular biomarker research. In this work, the high hydrophilic polyethylenimine conjugated polymaltose polymer brushes functionalized magnetic Fe3 O4 nanoparticles (NPs) denoted as Fe3 O4 -PEI-pMaltose were designed and synthesized via a simple two-step modification. The obtained superhydrophilic Fe3 O4 -PEI-pMaltose NPs displayed outstanding advantages in the enrichment of N-linked glycopeptides, including high selectivity (1:100, mass ratios of HRP and bovine serum albumin (BSA) digest), low detection limit (10 fmol), large binding capacity (200 mg/g), and high enrichment recovery (above 85%)...
February 28, 2018: ACS Omega
Janeni Natarajan, Giridhar Madras, Kaushik Chatterjee
We have developed nanocomposites based on galactitol/adipic acid in the molar ratio of 1:1 with different weight percentages of graphene oxide (GO). The objective of this study was to analyze the effect of enhanced physicochemical properties achieved due to the addition of GO to the polymers on cellular responses. The chemical structures of the polymer and composites were confirmed by Fourier transform infrared spectroscopy. Scanning electron microscopy revealed the uniform distribution of GO in the polymers...
September 30, 2017: ACS Omega
Arvind Gupta, Arbind Prasad, Neha Mulchandani, Manisha Shah, Mamilla Ravi Sankar, Sachin Kumar, Vimal Katiyar
The current work focuses on the fabrication of high-molecular-weight stereocomplex poly(lactic acid)/nanohydroxyapatite (sPLA/n-HAP)-based bionanocomposite for three-dimensional (3D)-printed orthopedic implants and high-temperature engineering applications. To achieve the same, n-HAP is grafted with poly(d-lactic acid) (PDLA) via in situ ring-opening polymerization of d-lactide, followed by blending with poly(l-lactic acid) (PLLA), which yields sPLA/n-HAP biocomposite with improved storage modulus even at temperatures higher than 140 °C...
July 31, 2017: ACS Omega
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