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T-spot tb in renal transplant patients

Satoru Ishikawa, Hidetoshi Igari, Naotake Akutsu, Mizue Tsuyuzaki, Hiromichi Aoyama, Masayuki Hasegawa, Kazunori Otsuki, Michihiro Maruyama, Kenichi Saigo, Kiminori Suzuki, Fumio Yamagishi
Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and progressing to active tuberculosis (TB). This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ release assays (IGRAs), QuantiFERON® -TB Gold in Tube (QFT) and T-SPOT® .TB (TSPOT), in patients after renal transplantation for detecting latent TB infection (LTBI). Total 92 renal transplant recipients (median age 46 years, range 17-75) were prospectively enrolled, and QFT and TSPOT were concurrently examined...
July 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Martina Sester, Frank van Leth, Judith Bruchfeld, Dragos Bumbacea, Daniela M Cirillo, Asli Gorek Dilektasli, José Domínguez, Raquel Duarte, Martin Ernst, Fusun Oner Eyuboglu, Irini Gerogianni, Enrico Girardi, Delia Goletti, Jean-Paul Janssens, Inger Julander, Berit Lange, Irene Latorre, Monica Losi, Roumiana Markova, Alberto Matteelli, Heather Milburn, Pernille Ravn, Theresia Scholman, Paola M Soccal, Marina Straub, Dirk Wagner, Timo Wolf, Aslihan Yalcin, Christoph Lange
RATIONALE: In the absence of active tuberculosis, a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA) result defines latent infection with Mycobacterium tuberculosis, although test results may vary depending on immunodeficiency. OBJECTIVES: This study compared the performance of TST and IGRAs in five different groups of immunocompromised patients, and evaluated their ability to identify those at risk for development of tuberculosis. METHODS: Immunocompromised patients with HIV infection, chronic renal failure, rheumatoid arthritis, solid-organ or stem-cell transplantation, and healthy control subjects were evaluated head-to-head by the TST, QuantiFERON-TB-Gold in-tube test (ELISA), and T-SPOT...
November 15, 2014: American Journal of Respiratory and Critical Care Medicine
Roya Sherkat, Majid Yaran, Parisa Shoaie, Mojgan Mortazavi, Shahrzad Shahidi, Hossein Hamidi, Shiva Seirafian, Shahram Taheri, Ziba Farajzadegan, Soodabeh Rostami
BACKGROUND: Detection of latent tuberculosis infection (LTBI) in transplant candidates is very important. The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are standard immunologic tools for LTBI detection. The aim of this study was to compare the TST results and T-SPOT(®).TB test (a type of IGRAs) in kidney transplant candidates for the screening of LTBI and follow the patients with positive test for an activation of tuberculosis (TB) after transplantation and using anti-TB prophylaxis...
March 2014: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Karine Hadaya, Pierre-Olivier Bridevaux, Pascale Roux-Lombard, Armelle Delort, Patrick Saudan, Pierre-Yves Martin, Jean-Paul Janssens
BACKGROUND: Renal transplant recipients (RTRs), as all immunosuppressed patients, are at increased risk of reactivating latent tuberculosis infection (LTBI). Detecting LTBI in this population is therefore important to prevent active TB. The tuberculin skin test (TST) has a poor sensitivity in this setting. METHODS: The aim of this prospective study was to compare the diagnostic performance of the TST and two interferon-γ release assays (IGRAs): T-SPOT.TB (Oxford Immunotec, Oxford, UK) and QuantiFERON Gold In-Tube (QGIT; Cellestis, Australia), performed simultaneously, for the detection of patients with risk factors for LTBI or a definite history of TB among RTRs under stable immunosuppression...
June 27, 2013: Transplantation
S-H Kim, S-O Lee, I-A Park, S J Park, S-H Choi, Y S Kim, J H Woo, S-K Park, J S Park, S C Kim, D J Han
BACKGROUND: The presence of latent tuberculosis (TB) infection (LTBI) should be evaluated before kidney transplantation. Although a new T cell-based assay for diagnosing LTBI gave promising results, this assay has not yet been compared with the tuberculin skin test (TST) for diagnosing LTBI in renal transplant candidates before transplantation. PATIENTS AND METHODS: All adult patients admitted to a single institute for renal transplantation over a 1-year period were prospectively enrolled...
April 2010: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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