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international study group for pancreatic surgery

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https://www.readbyqxmd.com/read/27865590/sphincter-of-oddi-botulinum-toxin-injection-to-prevent-pancreatic-fistula-after-distal-pancreatectomy
#1
Thilo Hackert, Ulla Klaiber, Ulf Hinz, Tzveta Kehayova, Pascal Probst, Phillip Knebel, Markus K Diener, Lutz Schneider, Oliver Strobel, Christoph W Michalski, Alexis Ulrich, Peter Sauer, Markus W Büchler
BACKGROUND: Postoperative pancreatic fistula represents the most important complication after distal pancreatectomy. The aim of this study was to evaluate the use of a preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula (German Clinical Trials Register number: DRKS00007885). METHODS: This was an investigator-initiated, prospective clinical phase I/II trial with an exploratory study design. We included patients who underwent preoperative endoscopic sphincter botulinum toxin injection (100 units of Botox)...
November 16, 2016: Surgery
https://www.readbyqxmd.com/read/27865280/postpancreatectomy-complications-and-management
#2
REVIEW
Giuseppe Malleo, Charles M Vollmer
Although mortality rates after pancreatectomy have decreased, the incidence of postoperative morbidity remains high. The major procedure-related complications are pancreatic fistula, delayed gastric emptying, and postpancreatectomy hemorrhage. The International Study Group of Pancreatic Surgery defined leading complications in a standardized fashion, allowing unbiased comparison of operative results and management strategies. Risk factors for postoperative complications have been investigated and quantitative scoring systems established to estimate patient-specific risks...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27822633/survival-analysis-and-risk-for-progression-of-intraductal-papillary-mucinous-neoplasia-of-the-pancreas-ipmn-under-surveillance-a-single-institution-experience
#3
Marco Del Chiaro, Zeeshan Ateeb, Marcus Reuterwall Hansson, Elena Rangelova, Ralf Segersvärd, Nikolaos Kartalis, Christoph Ansorge, Matthias J Löhr, Urban Arnelo, Caroline Verbeke
PURPOSE: While surveillance of the majority of patients with IPMN is considered best practice, consensus regarding the duration of follow-up is lacking. This study assessed the survival rate and risk for progression of IPMN under surveillance. METHODS: All patients diagnosed with and surveyed for IPMN between January 2008 and December 2013 were identified and assigned to two groups: patients without indication for surgery (Group 1), and patients whose IPMN required surgery but were inoperable for general reasons (Group 2)...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27811505/early-and-late-complications-after-surgery-for-men1-related-nonfunctioning-pancreatic-neuroendocrine-tumors
#4
Sjoerd Nell, Inne H M Borel Rinkes, Helena M Verkooijen, Bert A Bonsing, Casper H van Eijck, Harry van Goor, Ruben H J de Kleine, Geert Kazemier, Elisabeth J Nieveen van Dijkum, Cornelis H C Dejong, Gerlof D Valk, Menno R Vriens
OBJECTIVE: To estimate short and long-term morbidity after pancreatic surgery for multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). BACKGROUND: Fifty percent of the MEN1 patients harbor multiple NF-pNETs. The decision to proceed to NF-pNET surgery is a balance between the risk of disease progression versus the risk of surgery-related morbidity. Currently, there are insufficient data on the surgical complications after MEN1 NF-pNET surgery...
November 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27742480/assessing-the-role-of-primary-tumour-resection-in-patients-with-synchronous-unresectable-liver-metastases-from-pancreatic-neuroendocrine-tumour-of-the-body-and-tail-a-propensity-score-survival-evaluation
#5
E Bertani, N Fazio, D Radice, C Zardini, G Spinoglio, A Chiappa, D Ribero, R Biffi, S Partelli, M Falconi
BACKGROUND: The role of primary tumour surgery in pancreatic neuroendocrine tumours (PNETs) with unresectable liver metastases is controversial and international guidelines do not recommend surgery in such cases. Resectability of the primary tumour has never been considered in outcome comparisons between operated and non-operated patients. METHODS: From two institutional prospective databases of patients affected by PNET and unresectable liver metastases, 63 patients who underwent a left-pancreatectomy at diagnosis were identified and compared with a group of 30 patients with a potentially resectable but not-resected primary tumour located in the body or tail...
September 30, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27704248/effect-of-postoperative-major-complications-on-prognosis-after-pancreatectomy-for-pancreatic-cancer-a-retrospective-review
#6
Yusuke Watanabe, Kazuyoshi Nishihara, Sokichi Matsumoto, Takafumi Okayama, Yuji Abe, Toru Nakano
PURPOSE: To investigate the impact of postoperative complications on survival after curative resection for pancreatic cancer. METHODS: We reviewed retrospectively the medical records of 122 patients who underwent curative R0 resection for pancreatic cancer. Major complications included pancreatic fistula and hemorrhage of grade B or C according to the International Study Group of Pancreatic Fistula or Surgery criteria, and other complications of grade ≥III according to the Clavien-Dindo classification...
October 4, 2016: Surgery Today
https://www.readbyqxmd.com/read/27693645/comparing-3-guidelines-on-the-management-of-surgically-removed-pancreatic-cysts-with-regard-to-pathological-outcome
#7
Selma J Lekkerkerker, Marc G Besselink, Olivier R Busch, Joanne Verheij, Marc R Engelbrecht, Erik A Rauws, Paul Fockens, Jeanin E van Hooft
BACKGROUND AND AIMS: Currently, 3 guidelines are available for the management of pancreatic cysts. These guidelines vary in their indication for resection of high-risk cysts. We retrospectively compared the final pathological outcome of surgically removed pancreatic cysts with the indications for resection according to 3 different guidelines. METHODS: Patients who underwent pancreatic resection were extracted from our prospective pancreatic cyst database (2006-present)...
September 29, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27692778/definition-and-classification-of-chyle-leak-after-pancreatic-operation-a-consensus-statement-by-the-international-study-group-on-pancreatic-surgery
#8
Marc G Besselink, L Bengt van Rijssen, Claudio Bassi, Christos Dervenis, Marco Montorsi, Mustapha Adham, Horacio J Asbun, Maximillian Bockhorn, Oliver Strobel, Markus W Büchler, Olivier R Busch, Richard M Charnley, Kevin C Conlon, Laureano Fernández-Cruz, Abe Fingerhut, Helmut Friess, Jakob R Izbicki, Keith D Lillemoe, John P Neoptolemos, Michael G Sarr, Shailesh V Shrikhande, Robert Sitarz, Charles M Vollmer, Charles J Yeo, Werner Hartwig, Christopher L Wolfgang, Dirk J Gouma
BACKGROUND: Recent literature suggests that chyle leak may complicate up to 10% of pancreatic resections. Treatment depends on its severity, which may include chylous ascites. No international consensus definition or grading system of chyle leak currently is available. METHODS: The International Study Group on Pancreatic Surgery, an international panel of pancreatic surgeons working in well-known, high-volume centers, reviewed the literature and worked together to establish a consensus on the definition and classification of chyle leak after pancreatic operation...
September 28, 2016: Surgery
https://www.readbyqxmd.com/read/27686238/outcomes-after-extended-pancreatectomy-in-patients-with-borderline-resectable-and-locally-advanced-pancreatic-cancer
#9
W Hartwig, A Gluth, U Hinz, D Koliogiannis, O Strobel, T Hackert, J Werner, M W Büchler
BACKGROUND: In the recent International Study Group of Pancreatic Surgery (ISGPS) consensus on extended pancreatectomy, several issues on perioperative outcome and long-term survival remained unclear. Robust data on outcomes are sparse. The present study aimed to assess the outcome of extended pancreatectomy for borderline resectable and locally advanced pancreatic cancer. METHODS: A consecutive series of patients with primary pancreatic adenocarcinoma undergoing extended pancreatectomies, as defined by the new ISGPS consensus, were compared with patients who had a standard pancreatectomy...
September 30, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27678363/risk-factors-for-postoperative-pancreatic-fistula-analysis-of-539-successive-cases-of-pancreaticoduodenectomy
#10
Bing-Yang Hu, Tao Wan, Wen-Zhi Zhang, Jia-Hong Dong
AIM: To analyze the risk factors for pancreatic fistula after pancreaticoduodenectomy. METHODS: We conducted a retrospective analysis of 539 successive cases of pancreaticoduodenectomy performed at our hospital from March 2012 to October 2015. Pancreatic fistula was diagnosed in strict accordance with the definition of pancreatic fistula from the International Study Group on Pancreatic Fistula. The risk factors for pancreatic fistula were analyzed by univariate analysis and multivariate logistic regression analysis...
September 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27485058/defining-post-operative-pancreatitis-as-a-new-pancreatic-specific-complication-following-pancreatic-resection
#11
REVIEW
Saxon Connor
INTRODUCTION: Post-operative pancreatic fistula has been well defined. However the underlying aetiology remains poorly understood. The aim of this review was to investigate whether the underlying aetiology for a proportion of patients suffering from post-operative pancreatic fistula was due to post-operative pancreatitis. METHOD: A systematic literature review according to the PRISMA guidelines. The date range was from 2005 to 2016. The search strategy included the terms: post-operative pancreatitis, pathophysiology, post-operative pancreatic fistula, pancreaticoduodenectomy, ischaemic pancreatitis, microcirculation and pancreatitis, serum and drain amylase and lipase...
August 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27433897/grading-of-surgeon-technical-performance-predicts-postoperative-pancreatic-fistula-for-pancreaticoduodenectomy-independent-of-patient-related-variables
#12
Melissa E Hogg, Mazen Zenati, Stephanie Novak, Yong Chen, Yan Jun, Jennifer Steve, Stacy J Kowalsky, David L Bartlett, Amer H Zureikat, Herbert J Zeh
OBJECTIVE: To evaluate and quantify surgical skill by grading surgical performance of the pancreaticojejunostomy from robotic pancreaticoduodenectomies (RPDs). We hypothesized that video grading of surgical performance would contribute to estimating risk of postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy. BACKGROUND: POPF majorly contributes to pancreaticoduodenectomy morbidity. Risk scores [Fistula Risk Score (FRS) and Braga] derived from patient variables are validated for predicting POPF...
September 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27298107/intraoperative-acidosis-is-a-new-predictor-for-postoperative-pancreatic-fistula-after-pancreaticoduodenectomy
#13
Erdem Kinaci, Mert Mahsuni Sevinc, Abdulkerim Ozakay, Savas Bayrak, Ekrem Cakar, Serkan Sari
BACKGROUND: Early diagnosis of postoperative pancreatic fistula (POPF) is important for proper interventions. The preoperative, intraoperative and early postoperative biochemical markers have predictive value of POPF. The present study was to evaluate several simple biochemical parameters in the prediction of POPF. METHODS: Patients who underwent pancreaticoduodenectomy in our center between 2006 and 2015 were reviewed retrospectively. Preoperative and early postoperative biochemical parameters were evaluated...
June 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27206502/c-reactive-protein-and-procalcitonin-as-predictors-of-postoperative-inflammatory-complications-after-pancreatic-surgery
#14
A Giardino, G Spolverato, P Regi, I Frigerio, F Scopelliti, R Girelli, Z Pawlik, P Pederzoli, C Bassi, G Butturini
BACKGROUND: The association between postoperative inflammatory markers and risk of complications after pancreaticoduodenectomy (PD) is controversial. We sought to assess the diagnostic value of perioperative C-reactive protein (CRP) and procalcitonin (PCT) levels in the early identification of patients at risk for complications after PD. METHODS: In 2014, 84 patients undergoing elective PD were enrolled in a prospective database. Clinicopathological characteristics, CRP and PCT, as well as short-term outcomes, such as complications and pancreatic fistula, were analyzed...
August 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27200357/delayed-gastric-emptying-after-pancreatic-surgery-analysis-of-factors-determinant-for-the-short-term-outcome
#15
A Noorani, Elena Rangelova, M Del Chiaro, Lars Ragnar Lundell, Christoph Ansorge
BACKGROUND: Delayed gastric emptying (DGE) frequently complicates pancreatoduodenectomy (PD). Mainly DGE develops as consequence of postoperative intra-abdominal complications (secondary), while the incidence of primary DGE (i.e., not related to surgical complications) has rarely been studied. Moreover, the pathogenesis of DGE is complex and needs to be further elucidated. The present study aimed at highlighting potential mechanisms behind primary and above all secondary DGE by studying a variety of different pancreatic surgical procedures...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27083480/grade-b-pancreatic-fistulas-do-not-affect-survival-after-pancreatectomy-for-pancreatic-cancer-a-multicenter-observational-study
#16
Manabu Kawai, Yoshiaki Murakami, Fuyuhiko Motoi, Masayuki Sho, Sohei Satoi, Ippei Matsumoto, Goro Honda, Seiko Hirono, Ken-Ichi Okada, Michiaki Unno, Yoshiyuki Nakajima, Kenichiro Uemura, A-Hon Kwon, Takumi Fukumoto, Masanao Kurata, Hiroki Yamaue
BACKGROUND: Several studies have demonstrated that postoperative complications after pancreatectomy for pancreatic cancer adversely affect survival. The impact on survival of a pancreatic fistula according to the classification of the International Study Group for Pancreatic Surgery has not been fully evaluated. The aim of this multicenter, observational study was to evaluate the impact of pancreatic fistula on pancreatic cancer patients who had undergone pancreatectomy. METHODS: Between 2001 and 2012, 1,397 patients who underwent pancreatectomy for pancreatic cancer at 7 high-volume centers in Japan were reviewed retrospectively...
August 2016: Surgery
https://www.readbyqxmd.com/read/26970276/borderline-resectable-pancreatic-cancer
#17
REVIEW
Thilo Hackert, Alexis Ulrich, Markus W Büchler
Surgery followed by adjuvant chemotherapy remains the only treatment option for pancreatic ductal adenocarcinoma (PDAC) with the chance of long-term survival. If a radical tumor resection is possible, 5-year survival rates of 20-25% can be achieved. Pancreatic surgery has significantly changed during the past years and resection approaches have been extended beyond standard procedures, including vascular and multivisceral resections. Consequently, borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC), which has recently been defined by the International Study Group for Pancreatic Surgery (ISGPS), has become a controversial issue with regard to its management in terms of upfront resection vs...
June 1, 2016: Cancer Letters
https://www.readbyqxmd.com/read/26944001/diagnosis-treatment-and-long-term-outcomes-of-autoimmune-pancreatitis-in-spain-based-on-the-international-consensus-diagnostic%C3%A2-criteria-a-multi-centre-study
#18
Antonio López-Serrano, Javier Crespo, Isabel Pascual, Silvia Salord, Federico Bolado, Andrés J Del-Pozo-García, Lucas Ilzarbe, Enrique de-Madaria, Eduardo Moreno-Osset
OBJECTIVES: Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis that has been reported worldwide for the last two decades. The aim of this study is to analyse the clinical profile of patients from Spain with AIP, as well as treatments, relapses and long-term outcomes. METHODS: Data from 59 patients with suspected AIP that had been diagnosed in 15 institutions are retrospectively analysed. Subjects are classified according to the International Consensus Diagnostic Criteria (ICDC)...
May 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/26929287/hemorrhage-after-major-pancreatic-resection-incidence-risk-factors-management-and-outcome
#19
D Ansari, B Tingstedt, G Lindell, I Keussen, D Ansari, R Andersson
BACKGROUND AND AIMS: Hemorrhage is a rare but dreaded complication after pancreatic surgery. The aim of this study was to examine the incidence, risk factors, management, and outcome of postpancreatectomy hemorrhage in a tertiary care center. MATERIALS AND METHODS: A retrospective observational study was conducted on 500 consecutive patients undergoing major pancreatic resections at our institution. Postpancrea-tectomy hemorrhage was defined according to the International Study Group of Pancreatic Surgery criteria...
February 29, 2016: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/26927601/international-prospective-study-of-distal-intestinal-obstruction-syndrome-in-cystic-fibrosis-associated-factors-and-outcome
#20
Anne Munck, Corinne Alberti, Carla Colombo, Nataliya Kashirskaya, Helmut Ellemunter, Maria Fotoulaki, Roderick Houwen, Eddy Robberecht, Priscilla Boizeau, Michael Wilschanski
BACKGROUND: Distal intestinal obstruction syndrome (DIOS) is a specific complication of cystic fibrosis. METHODS: A study was performed in 10 countries to prospectively evaluate the incidence, associated factors, and treatment modalities in children and adults. RESULTS: 102 patients presented 112 episodes. The incidence of DIOS was similar in children and adults. Medical treatment failed only in cases of complete DIOS (11%). Children with meconium ileus had a higher rate of surgery for DIOS (15% vs...
July 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
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