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Prutha D Aloni, Amit R Nayak, Sweta R Chaurasia, Jayant Y Deopujari, Chhaya Chourasia, Hemant J Purohit, Girdhar M Taori, Hatim F Daginawala, Rajpal S Kashyap
Fagonia arabica (FA) possesses a thrombolytic property which has been earlier reported in our laboratory. Current study was undertaken to investigate the effect of aqueous extract of FA on thrombin-induced tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) release from cultured human umbilical vein endothelial cell line (HUVE) for studying its clot lytic activity. For this, establishment of cell line model has been done by isolating the cells from human umbilical cord. Cell toxicity was evaluated using XTT assay...
July 2016: Journal of Traditional and Complementary Medicine
Fatima Syed, Khurshid Ali, Muhammad Javaid Asad, Muhammad Gul Fraz, Zahid Khan, Muhammad Imran, Raheela Taj, Aftab Ahmad
The preparation of green nano supports for the covalent immobilization of enzymes is of special interest both from the economic and environmental point of view. In this contribution, we report on the synthesis of phytochemicals coated silver nanoparticles, which were used as a novel green support for the covalent immobilization of glucoamylase isolated from Neurospora sitophila. The aqueous extract of Fagonia indica was used as a source of reducing and capping agents for the reduction of silver ions into silver nanoparticles...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
Muhammad Khurshid Alam, Saeed Ahmed, Shazia Anjum, Muhammad Akram, Syed Muhammad Ali Shah, Hafiz Muhammad Wariss, Khan Usmanghani
Traditional herbal healers "Hakims" use various plants of the Cholistan desert, Pakistan for treating a number of infectious and non-infectious diseases. However, there has never been a scientific validation of these plant-based therapeutics. We compared the antipyretic effect of Echinops echinatus, Alhagi maurorum, Fagonia cretica, Cymbopogon jwarancusa and Panicum turgidum in animal model. These plants were used to reduce E.coli lysate induced pyrexia in rabbits. There were five groups of rabbits having five rabbits in each group...
March 2016: Pakistan Journal of Pharmaceutical Sciences
Laila Jafri, Samreen Saleem, Danielle Calderwood, Anna Gillespie, Bushra Mirza, Brian D Green
Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were tested for GLP-1 and GIP secretory activity in pGIP/neo STC-1 cells. Intracellular levels of incretin hormones and their gene expression were also determined. Crude F. cretica extracts stimulated both GLP-1 and GIP secretion, increased cellular hormone content, and upregulated gene expression of proglucagon, GIP and prohormone convertase...
April 2016: Peptides
Tariq Khan, Bilal Haider Abbasi, Mubarak Ali Khan, Zabta Khan Shinwari
Fagonia indica, a very important anticancer plant, has been less explored for its in vitro potential. This is the first report on thidiazuron (TDZ)-mediated callogenesis and elicitation of commercially important phenolic compounds. Among the five different plant growth regulators tested, TDZ induced comparatively higher fresh biomass, 51.0 g/100 mL and 40.50 g/100 mL for stem and leaf explants, respectively, after 6 weeks of culture time. Maximum total phenolic content (202.8 μg gallic acid equivalent [GAE]/mL for stem-derived callus and 161...
April 2016: Applied Biochemistry and Biotechnology
Naglaa Gamil Shehab, Eman Abu-Gharbieh, Fatehia A Bayoumi
BACKGROUND: Flavonoids and other polyphenols play a protective role in liver diseases and possess a high antioxidant capacity. OBJECTIVE: To compare and evaluate the antioxidant and hepatotoprotective activities of 4 deserts plants, Fagonia indica Burm. f., Calotropis procera R.Br., Zygophylum hamiense Schweinf. and Salsola imbricata Forssk. in correlation to their composition especially their phenolic content. METHODS: The influence of extracting solvent on total phenolic and flavonoidal contents was assessed spectrophotometrically...
2015: BMC Complementary and Alternative Medicine
Huma Qureshi, Saira Asif, Haroon Ahmed, Hassan A Al-Kahtani, Khizar Hayat
Members of the family Zygophyllaceae are distributed in arid areas of the world and are traditionally used against various health insults ranging from skin lesions to lethal cancer. Fagonia cretica Linn. is a plant having novel compounds responsive in diseases that are still considered as incurable or are curable with serious side effects. Researchers, particularly of the Asian region elaborately studied the chemical composition and pharmacological activities of this plant. But further studies are still required to evaluate this plant in clinical trials in order to save humanity from synthetic chemical drugs yet disputed as 'friends or foe'...
2016: Natural Product Research
Amal Sallam, Alfarius Eko Nugroho, Yusuke Hirasawa, Wong Chin-Piow, Toshio Kaneda, Osamu Shirota, Sahar R Gedara, Hiroshi Morita
A new acyclic diterpenoid (1) and a new erythroxan diterpenoid (2), together with 4 erythroxan diterpenoids and 3 triterpenoids, have been isolated from the aerial parts of Fagonia mollis. Their structures were elucidated on the basis of 1D and 2D NMR data. The cytotoxic activity of the isolated compounds was investigated against HL-60 cancer cells.
September 2014: Natural Product Communications
Khalid Rehman, Zia-ur-Rehman Mashwani, Mubark Ali Khan, Zahid Ullah, Hassan Javed Chaudhary
ETHNO PHARMACOLOGICAL RELEVANCE: The present study was carried out with an aim to gather, evaluate and analyze the ethno botanical information of medicinal uses of the plant species possessed by the native Khattak tribe of the Chonthra, district Karak Pakistan. The region with poor documentation of traditional knowledge, preserving the local traditional knowledge, reporting new as well as rarely reported medicinal properties of medicinal plants, to be tested experimentally for validation...
May 13, 2015: Journal of Ethnopharmacology
Sophie Lorraine Vassou, G Kusuma, Madasamy Parani
The majority of the plant materials used in herbal medicine is procured from the markets in the form of dried or powdered plant parts. It is essential to use authentic plant materials to derive the benefits of herbal medicine. However, establishing the identity of these plant materials by conventional taxonomy is extremely difficult. Here we report a case study in which the species identification of the market samples of Sida cordifolia was done by DNA barcoding. As a prelude to species identification by DNA barcoding, 13 species of Sida were collected, and a reference DNA barcode library was developed using rbcL, matK, psbA-trnH and ITS2 markers...
March 15, 2015: Gene
Shafi Ullah, Muhammad Rashid Khan, Naseer Ali Shah, Sayed Afzal Shah, Muhammad Majid, Muhammad Asad Farooq
AIM OF THE STUDY: Medicinal plants are regional treasures for the treatment of many ailments. The present research investigated and documented knowledge of indigenous commonly used medicinal plants, including traditional names, preparations and uses, in the Lakki Marwat District of Pakistan. The information gathered was statistically analyzed using the ICF method to establish baseline data for more comprehensive investigations of bioactive compounds of indigenous medicinal plants. MATERIALS AND METHODS: Direct interviews of 78 informants were conducted during 2013-2014 to identify the preparations and uses of indigenous medicinal plants...
December 2, 2014: Journal of Ethnopharmacology
Pervaiz Iqbal, Dildar Ahmed, Muhammad Nadeem Asghar
OBJECTIVE: To evaluate antioxidant and radical scavenging activities of organic extracts from fruit, roots and aerial parts of Fagonia cretica. METHODS: Shed dried and powdered plant parts were initially extracted in methanol and subsequently partitioned in n-hexane, chloroform, ethyl acetate and 1-butanol successively. Antioxidant and radical scavenging potential of the methanol extracts and the fractions of each part were evaluated using total phenolic contents (TPC) and total flavonoid contents (TFC), 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation radicals scavenging, reducing power (potassium ferricyanide-trichloroacetic acid system), ferric ion reducing antioxidant potential, lipid peroxidation inhibition activity (linoleic acid system) and total antioxidant activity (phosphomolybdate) assays...
September 2014: Asian Pacific Journal of Tropical Medicine
Samreen Saleem, Laila Jafri, Ihsan ul Haq, Leng Chee Chang, Danielle Calderwood, Brian D Green, Bushra Mirza
ETHNOPHARMACOLOGICAL RELEVANCE: The two plants investigated here (Fagonia cretica L. and Hedera nepalensis K. Koch) have been previously reported as natural folk medicines for the treatment of diabetes but until now no scientific investigation of potential anti-diabetic effects has been reported. MATERIALS AND METHODS: In vitro inhibitory effect of the two tested plants and their five isolated compounds on the dipeptidyl peptidase 4 (DPP-4) was studied for the assessment of anti-diabetic activity...
October 28, 2014: Journal of Ethnopharmacology
Ghulam Dastagir, Farrukh Hussain
The methanolic and n-hexane extracts of studied plants showed significant toxicity to brine shrimps. The methanolic extract of Fagonia cretica had highest LD50 (117.72) value, while Peganum harmala showed low LD50 value (41.70) compared to n-hexane extract. The methanolic and n-hexane extracts of Tribulus terrestris showed similar LD50 values. The methanolic extract of Chrozophora tinctoria showed low LD50 value than the n-hexane extract. The methanolic extract of Ricinus communis showed highest LD50 value while the n-hexane extract showed lowest LD50 value...
July 2014: Pakistan Journal of Pharmaceutical Sciences
Bazigha Kadhim Abdul Rasool, Naglaa Gamil Shehab, Saeed Ahmed Khan, Fatehia Aly Bayoumi
Fagonia indica Burm f. (Mushikka or white spine) is a plant distributed in the deserts of Asia and Africa and reported to be medicinal in the scientific literature as well as in the folk medicine. Earlier investigations, the authors isolated a number of bioactive constituents from the plant including flavonoids, sterols and tritepenoids; In addition its flavonoidal content was found remarkably high reaching 3% (calculated as flavonol on dry weight). The present study is an attempt to formulate, characterize and evaluate a natural wound-healing gel preparation containing the crude plant extract...
January 2014: Pakistan Journal of Pharmaceutical Sciences
Ravindra Satpute, Rahul Bhattacharya, Rajpal S Kashyap, Hemant J Purohit, Jayant Y Deopujari, Girdhar M Taori, Hatim F Daginawala
The imbalance between pro-oxidants and anti-oxidants leads to generation of oxygen/nitrogen free radicals which are implicated in several neurodegenerative diseases. Fagonia arabica is an ethno-pharmacologically important Ayurvedic herb known to have many medicinal properties like anti-inflammatory, analgesic and antipyretic effects. However, its antioxidant potential has not been investigated so far. The present study was designed to investigate the antioxidant potential of F. arabica and its neuroprotective effect on chemical ischemia induced in PC12 cells...
2012: Iranian Journal of Pharmaceutical Research: IJPR
Anil Pareek, Ashok Godavarthi, Roshan Issarani, Badri Prakash Nagori
ETHNOPHARMACOLOGICAL RELEVANCE: The whole plant of Fagonia schweinfurthii (Hadidi) Hadidi (Family: Zygophyllaceae) is used in variety of diseases including hepatic ailments in deserts and dry areas of India. AIM OF THE STUDY: To evaluate antioxidant and hepatoprotective activity of ethanolic extract from Fagonia schweinfurthii (Hadidi) Hadidi (FSEE) in carbon tetrachloride (CCl4) induced hepatotoxicity in HepG2 cell line and rats. MATERIALS AND METHODS: In vitro antioxidant activity was determined by DPPH, ABTS radicals and hydrogen peroxide methods...
December 12, 2013: Journal of Ethnopharmacology
Wafaa M El-Ghanim, Loutfy M Hassan, Tarek M Galal, Abdelfattah Badr
In this study, 19 sites representing different habitats in Hail region were regularly visited for two years, in each site 2-5 stands were selected for investigating floristic composition and vegetation types in the area. A total of 124 species representing 34 families were recorded. The family Asteraceae is represented by the highest number of species (21 species) followed by the Poaceae (17 species) and the Brassicaceae (10 species) whereas, 15 families including Acanthaceae, Convolvulaceae, Moraceae, Nyctaginaceae and Primulaceae, are represented by a single species each...
April 2010: Saudi Journal of Biological Sciences
Umbreen Rashid, Muhammad Rashid Khan, Shumaila Jan, Jasia Bokhari, Naseer Ali Shah
BACKGROUND: In Pakistan Fagonia olivieri (Zygophyllaceae) is commonly used in the indigenous system of medicine for treatment of conditions like diabetes, cancer, fever, asthma, toothache, stomach troubles and kidney disorders. This study evaluated the crude methanol extract of F. olivieri (FOM) and its derived fractions for their antimicrobial and cytotoxic activities as well as the classes of phytochemical. METHODS: Dried powder of whole plant of F. olivieri was extracted with methanol (FOM) and the resultant was fractionated to give n-hexane fraction (FOH), chloroform fraction (FOC), ethyl acetate fraction (FOE), n-butanol fraction (FOB) and residual aqueous fraction (FOA)...
2013: BMC Complementary and Alternative Medicine
Sweta R Chourasia, Rajpal Singh Kashyap, Jayant Y Deopujari, Hemant J Purohit, Girdhar M Taori, Hatim F Daginawala
Fagonia arabica (FA) is a deobstruent and blood purifier, which possesses thrombolytic and antioxidant activities. In this study, the anticoagulant effects of FA and its derived fractions were evaluated. Plasma recalcification was performed with multisolvent extracts of FA and then with extracts prepared successively with increasing polarity of the solvents. Aqueous extract was the most potent anticoagulant extract, which was fractionated by thin-layer chromatography and column chromatography. Five fractions collected were checked for their anticoagulation effect...
November 2014: Clinical and Applied Thrombosis/hemostasis
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