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Melanoma in situ

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https://www.readbyqxmd.com/read/29037804/fluorescence-in-situ-hybridisation-as-an-ancillary-tool-in-the-diagnosis-of-acral-melanoma-a-review-of-44-cases
#1
Jing Su, Wenjuan Yu, Jianying Liu, Jie Zheng, Sixia Huang, Yuchen Wang, Shuangshuang Qi, Xiaolong Ma, Jian Chen, Yan Zhang
Acral melanoma is associated with outcomes which are more unfavourable than those of other melanoma subtypes, and acral melanoma has higher mortality. However, histological distinction of acral melanoma from acral naevi may be difficult. Fluorescence in situ hybridisation (FISH) targeting specific genes has been used as an ancillary method for differential diagnosis of melanocytic tumours, but most previous studies have focused on non-acral lesions which may have genetic alterations different from acral lesions...
October 13, 2017: Pathology
https://www.readbyqxmd.com/read/29027288/cxxc5-expression-in-prostate-cancer-implications-for-cancer-progression
#2
Ines Benedetti, Angelo M De Marzo, Jan Geliebter, Niradiz Reyes
Identification of genes specifically deregulated in prostate adenocarcinoma may lead to discovery of new oncogenes/tumour suppressors with clinical relevance for diagnosis, prognosis and/or therapy. CXXC5 is a gene encoding a retinoid-inducible nuclear factor, whose overexpression in breast tumours, metastatic malignant melanomas and papillary thyroid carcinoma has been recently reported. We previously found differential expression of CXXC5 transcripts in metastatic prostate cancer cell lines of both rat and human origin...
August 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29018888/-non-melanoma-skin-cancer-pathogenesis-prevalence-and-prevention
#3
A Zink
Non-melanoma skin cancer (NMSC) is the most common malignancy of the light-skinned population with an enormous socioeconomic impact. Historically known as incurable under the term noli me tangere (transl. do not touch me), today various non-melanocytic cutaneous neoplasms are grouped as NMSC. The most common of these, basal cell carcinoma, squamous cell carcinoma and actinic keratoses as carcinomas in situ, are increasingly called keratinocyte carcinoma. Today, the pathogenesis and risk factors of NMSC are relatively well understood, which has led to multiple treatment options, the recognition of NMSC as an occupational disease in Germany and a variety of prevention approaches...
October 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28979663/finger-pad-squamous-cell-carcinoma-report-of-squamous-cell-carcinoma-of-the-distal-palmar-digit-and-review-of-associated-risk-factors-mimickers-and-treatment-of-squamous-cell-carcinoma-of-ventral-hand-digits
#4
Philip R Cohen, S Brian Jiang
BACKGROUND: Squamous cell carcinoma of the palmar digits is rare. PURPOSE: The authors describe a man with squamous cell carcinoma of the pulp of his left fourth finger, and review the risk factors that may be associated with squamous cell carcinoma development on the ventral digits of the hand. the authors also summarize the clinical differential diagnoses and treatment of squamous cell carcinoma at this location. METHODS: the authors retrospectively reviewed the literature using PubMed and searched for the following terms: squamous cell carcinoma, squamous cell carcinoma in situ, finger, thumb, palmar, and ventral...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28966533/a-case-of-subungual-melanoma-in-situ-in-an-18-year-old-girl-presented-with-total-melanonychia
#5
Cheong Ha Woo, Seung Pil Ham, Mira Choi, Hai-Jin Park
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28944501/synergistic-effects-of-interferon-beta-and-nivolumab-in-oral-mucosal-melanoma
#6
Takayuki Fusumae, Koji Kamiya, Binluen Chiang, Hirofumi Okada, Naomi Nakano, Takeo Maekawa, Mayumi Komine, Satoru Murata, Mamitaro Ohtsuki
Mucosal melanoma is a rare aggressive cancer with a very poor prognosis. Clinical and pathological characteristics of mucosal melanoma differ from those of cutaneous melanoma and there are no established management guidelines for mucosal melanoma. Complete surgical excision is one of the most effective treatments for localized lesions, while targeted therapies and immunotherapies, such as monoclonal antibodies that target cytotoxic T-lymphocyte-associated molecule-4, and the programmed death (PD)-1/PD-ligand 1 pathway inhibitors, are treatment options for unresectable or metastatic lesions...
September 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28936478/recurrence-rate-of-melanoma-in-situ-when-treated-with-serial-disk-staged-excision-a-case-series
#7
Daniel Garcia, Robert E Eilers, S Brian Jiang
BACKGROUND: Cutaneous melanoma is one of the fastest rising cancer diagnoses in recent years. Melanoma in situ (MIS) constitutes a large proportion of all diagnosed melanomas. While surgical excision is considered the standard of therapy, the literature is not clear on which surgical technique minimizes local recurrence. A common technique is serial staged excision (SSE), in which a series of mapped excisions are made according to histopathological examination of tissue. Previously published recurrence rates for SSE ranges from 0-12%, over a range of 4...
February 2017: Journal of Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28899863/a-unified-approach-to-targeting-the-lysosome-s-degradative-and-growth-signaling-roles
#8
Vito W Rebecca, Michael C Nicastri, Noel McLaughlin, Colin Fennelly, Quentin McAfee, Amruta Ronghe, Michel Nofal, Chun-Yan Lim, Eric Witze, Cynthia I Chude, Gao Zhang, Gretchen M Alicea, Shengfu Piao, Sengottuvelan Murugan, Rani Ojha, Samuel M Levi, Zhi Wei, Julie S Barber-Rotenberg, Maureen E Murphy, Gordon B Mills, Yiling Lu, Joshua Rabinowitz, Ronen Marmorstein, Qin Liu, Shujing Liu, Xiaowei Xu, Meenhard Herlyn, Roberto Zoncu, Donita C Brady, David W Speicher, Jeffrey D Winkler, Ravi K Amaravadi
Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as chloroquine or quinacrine have been used as lysosomal inhibitors, but fail to inhibit mTOR signaling. Further, the molecular target of these agents has not been identified. We report a screen of novel dimeric antimalarials that identifies dimeric quinacrines (DQ) as potent anticancer compounds, which concurrently inhibit mTOR and autophagy...
September 12, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28886809/detection-of-genetic-aberrations-in-the-assessment-and-prognosis-of-melanoma
#9
REVIEW
Whitney A High
The assessment of melanoma by light microscopy with hematoxylin-eosin staining remains an often subjective process. However, there are additional diagnostic measures that may be of utility, such as immunohistochemical staining and genetic evaluation. Adjunctive genetic assessment to augment the diagnosis of melanoma includes comparative genomic hybridization or fluorescent in situ hybridization to assess for gains or losses in genetic material, or gene expression profiling in some form, to ascertain the expression of genes associated with malignancy...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28885974/melanoma-in-an-active-duty-marine
#10
Samantha J Bartling, Shayna C Rivard, Jon H Meyerle
Given that the majority of active duty service members are young and healthy, potentially malignant diagnoses such as skin cancer may be overlooked. Although melanoma accounts for only approximately 1% of skin cancers, it causes the greatest majority of skin cancer deaths. We present the case of a 27-year-old active duty Marine who presented with a hyperpigmented macule at his lateral neck that was a malignant melanoma in situ. This article reviews risk factors for the development of melanoma, offers guidelines for primary care providers, reviews resources for providers in a deployed or austere environment, offers recommendations for prevention and early diagnosis, and discusses follow up...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28885326/melanoma-in-situ-of-penis-a-very-rare-entity-a-case-report-and-review-of-the-literature
#11
Roberto Baraziol, Mauro Schiavon, Eugenio Fraccalanza, Gioacchino De Giorgi
RATIONALE: Melanoma in situ of the penis is very rare and there are no clear guidelines for its surgical treatment. PATIENT CONCERNS: The authors describe the case of a 69-year-old man who presented with an asymptomatic brown macula on his glans penis and foreskin that appeared about 8 years earlier, enlarged in the last few months. DIAGNOSES: A diagnostic biopsy showed the characteristics of a melanoma in situ. INTERVENTIONS: The authors decided to excise the lesion keeping a healthy margin of 1 cm all over around except close to the urethral meatus, where it was impossible, and where only 5 mm of free margin was excised...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28881040/comprehensive-histopathologic-comparison-of-epidermotropic-dermal-metastatic-melanoma-and-primary-nodular-melanoma
#12
Stephanie L Skala, David P Arps, Lili Zhao, Kelly B Cha, Min Wang, Paul W Harms, Aleodor A Andea, Douglas R Fullen, May P Chan
AIMS: Metastatic melanoma involving the epidermis and/or upper dermis may show significant histologic overlap with primary cutaneous melanoma, especially the nodular subtype. Proper histopathologic classification is crucial to appropriate staging and management, yet often challenging. This study aims to identify helpful histopathologic features in differentiating epidermotropic/dermal metastatic melanoma (EDMM) and primary nodular melanoma (PNM). METHODS AND RESULTS: A cohort of EDMM (n=74) and PNM (n=75) was retrospectively reviewed for various histopathologic features, and the data were compared between groups by univariate analysis...
September 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28872561/topical-imiquimod-for-melanoma-in-situ-a-word-of-caveat
#13
Ulrike Wehkamp, Thomas Schwarz
No abstract text is available yet for this article.
August 11, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28871933/prognostic-predictors-of-thin-melanoma-in-clinico-pathological-practice
#14
Luca Roncati, Teresa Pusiol, Francesco Piscioli
The latest reviews on thin melanoma (TM) continue to consider it a melanoma within 1 mm in thickness, but no consensus exists as to which patients with TM are at risk for lymph node metastases (1). Numerous studies have evaluated the impact of various predictors (Breslow thickness, Clark level, ulceration, regression, vascular invasion, mitotic activity, location, sex) for nodal disease in melanoma, but the conclusions have not been homogenous (2,3). For this reason, we read the paper by Homolak et al. with great interest, where the authors examine the sentinel lymph node biopsies (SLNB) of 184 patients affected by melanoma of thickness less than 1...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28868278/conjunctival-melanoma-during-pregnancy
#15
Rana'a T Al-Jamal, Hardeep Singh Mudhar, Zanna Currie, Ian G Rennie, Sachin M Salvi
PURPOSE: To describe the clinical and histopathological features of a conjunctival melanoma (CM) during early pregnancy. PROCEDURES: A 37-year-old, 20-week pregnant primigravida was referred to the Sheffield Ocular Oncology Service with a rapidly growing lesion arising from the right superior conjunctival fornix, noted from the first trimester of pregnancy. This was associated with pain and bloody discharge. Incisional biopsy confirmed the clinical suspicion of invasive CM...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868276/uveal-melanoma-regression-after-brachytherapy-relationship-with-chromosome-3-monosomy-status
#16
Sachin M Salvi, Hassan A Aziz, Suhail Dar, Nakul Singh, Brandy Hayden-Loreck, Arun D Singh
AIM: The objective was to evaluate the relationship between the regression rate of ciliary body melanoma and choroidal melanoma after brachytherapy and chromosome 3 monosomy status. METHODS: We conducted a prospective and consecutive case series of patients who underwent biopsy and brachytherapy for ciliary/choroidal melanoma. Tumor biopsy performed at the time of radiation plaque placement was analyzed with fluorescence in situ hybridization to determine the percentage of tumor cells with chromosome 3 monosomy...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28863272/recombinant-protein-rmbp-nap-restricts-tumor-progression-by-triggering-antitumor-immunity-in-mouse-metastatic-lung-cancer
#17
Ting Wang, Mingxuan Du, Zhenyu Ji, Cong Ding, Chengbo Wang, Yingli Men, Shimeng Liu, Taotao Liang, Xin Liu, Qiaozhen Kang
Recombinant Helicobacter pylori neutrophil-activating protein fused with Maltose- binding protein (rMBP-NAP), a potential TLR2 ligand, was reported to possess immunomodulatory effects on in-situ tumor in our previous study. In present work, we attempt to elucidate the effect of rMBP-NAP at the local immune modulation in B16-F10-induced metastatic lung cancer. Our results demonstrated that growth of B16-F10 melanoma metastases in the lung was significantly arrested after rMBP-NAP treatment, along with marked reduction in metastatic lung nodules and significant increase in survival...
September 1, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28858936/pathologists-use-of-second-opinions-in-interpretation-of-melanocytic-cutaneous-lesions-policies-practices-and-perceptions
#18
Berta M Geller, Paul D Frederick, Stevan R Knezevich, Jason P Lott, Heidi D Nelson, Linda J Titus, Patricia A Carney, Anna N A Tosteson, Tracy L Onega, Raymond L Barnhill, Martin A Weinstock, David E Elder, Michael W Piepkorn, Joann G Elmore
BACKGROUND: Research examining the role of second opinions in pathology for diagnosis of melanocytic lesions is limited. OBJECTIVE: To assess current laboratory policies, clinical use of second opinions, and pathologists' perceptions of second opinions for melanocytic lesions. MATERIALS AND METHODS: Cross-sectional data collected from 207 pathologists in 10 US states who diagnose melanocytic lesions. The web-based survey ascertained pathologists' professional information, laboratory second opinion policy, use of second opinions, and perceptions of second opinion value for melanocytic lesions...
August 29, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28836277/the-risk-of-preterm-birth-and-growth-restriction-in-pregnancy-after-cancer
#19
Kathleen P Hartnett, Kevin C Ward, Michael R Kramer, Timothy L Lash, Ann C Mertens, Jessica B Spencer, Amy Fothergill, Penelope P Howards
It is unclear whether cancer and its treatments increase the risk of adverse pregnancy outcomes. Our aim was to examine whether cancer survivors have higher risks of poor outcomes in pregnancies conceived after diagnosis than women without cancer, and whether these risks differ by cancer type and race. Diagnoses from cancer registries were linked to pregnancy outcomes from birth certificates in three U.S. states. Analyses were limited to the first, live singleton birth conceived after diagnosis. Births to women without a previous cancer diagnosis in the registry were matched to cancer survivors on age at delivery, parity, race/ethnicity and education...
August 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28808257/stochastic-model-of-contact-inhibition-and-the-proliferation-of-melanoma-in-situ
#20
Mauro César Cafundó Morais, Izabella Stuhl, Alan U Sabino, Willian W Lautenschlager, Alexandre S Queiroga, Tharcisio Citrangulo Tortelli, Roger Chammas, Yuri Suhov, Alexandre F Ramos
Contact inhibition is a central feature orchestrating cell proliferation in culture experiments; its loss is associated with malignant transformation and tumorigenesis. We performed a co-culture experiment with human metastatic melanoma cell line (SKMEL- 147) and immortalized keratinocyte cells (HaCaT). After 8 days a spatial pattern was detected, characterized by the formation of clusters of melanoma cells surrounded by keratinocytes constraining their proliferation. In addition, we observed that the proportion of melanoma cells within the total population has increased...
August 14, 2017: Scientific Reports
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