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Melanoma in situ

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https://www.readbyqxmd.com/read/27899996/quantitative-label-free-mass-spectrometry-analysis-of-formalin-fixed-paraffin-embedded-tissue-representing-the-invasive-cutaneous-malignant-melanoma-proteome
#1
Paul Dowling, Benvon Moran, Edel McAuley, Paula Meleady, Michael Henry, Martin Clynes, Mairin McMenamin, Niamh Leonard, Mary Monks, Bairbre Wynne, Patrick Ormond, Annemarie Larkin
Understanding the events at a protein level that govern the progression from melanoma in situ to invasive melanoma are important areas of current research to be developed. Recent advances in the analysis of formalin-fixed, paraffin-embedded tissue by proteomics, particularly using the filter-aided sample preparation protocol, has opened up the possibility of studying vast archives of clinical material and associated medical records. In the present study, quantitative protein profiling was performed using tandem mass spectrometry, and the proteome differences between melanoma in situ and invasive melanoma were compared...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899693/performance-testing-of-rreb1-myb-and-ccnd1-fluorescence-in-situ-hybridization-in-spindle-cell-and-desmoplastic-melanoma-argues-for-a-two-step-test-algorithm
#2
Stephanie E Weissinger, Manfred Frick, Peter Möller, Basil A Horst, Jochen K Lennerz
Background Diagnostic confirmation of spindle-cell melanoma (SM) or desmoplastic melanoma (DM) as a melanoma can be challenging. In conventional melanoma (CM), a recently established fluorescence in situ hybridization (FISH) assay for RREB1, MYB, CCND1 can be helpful. Here, we determined the presence of RREB1, MYB, and CCND1 abnormalities in an SM/DM/mixed cohort. Methods We assembled 49 cases and performed 3 separate hybridizations for RREB1/MYB/CCND1 We assessed clinical utility in diagnostically challenging cases and performed a cost and turnaround time analysis...
November 29, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27898656/interval-cancers-after-skin-cancer-screening-incidence-tumour-characteristics-and-risk-factors-for-cutaneous-melanoma
#3
J Hübner, A Waldmann, A C Geller, M A Weinstock, N Eisemann, M Noftz, S Bertram, S Nolte, B Volkmer, R Greinert, E Breitbart, A Katalinic
BACKGROUND: The rate of interval cancers is an established indicator for the performance of a cancer-screening programme. METHODS: We examined the incidence, tumour characteristics and risk factors of melanoma interval cancers that occurred in participants of the SCREEN project, which was carried out 2003/2004 in Schleswig-Holstein, Germany. Data from 350 306 SCREEN participants, who had been screened negative for melanoma, were linked to data of the state cancer registry...
November 29, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27889782/molecular-pathology-a-requirement-for-precision-medicine-in-cancer
#4
Manfred Dietel
The increasing importance of targeting drugs and check-point inhibitors in the treatment of several tumor entities (breast, colon, lung, malignant melanoma, lymphoma, etc.) and the necessity of a companion diagnostic (HER2, (pan)RAS, EGFR, ALK, BRAF, ROS1, MET, PD-L1, etc.) is leading to new challenges for surgical pathology. Since almost all the biomarkers to be specifically detected are tissue based, a precise and reliable diagnostic is absolutely crucial. To meet this challenge surgical pathology has adapted a number of molecular methods (semi-quantitative immunohistochemistry, fluorescence in situ hybridization, PCR and its multiple variants, (pyro/Sanger) sequencing, next generation sequencing (amplicon, whole exome, whole genome), DNA arrays, methylation analyses, etc...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27887797/mortality-burden-and-prognosis-of-thin-melanomas-overall-and-by-subcategory-of-thickness-seer-registry-data-1992-2013
#5
Shoshana M Landow, Annie Gjelsvik, Martin A Weinstock
BACKGROUND: Thin melanomas cause a high death toll despite excellent prognosis. OBJECTIVE: We examined melanoma mortality burden and prognosis by categories of thickness within Surveillance, Epidemiology, and End Results (SEER) 13 Registry 1992-2013. METHODS: We divided 49,319 stage I and II melanoma cases diagnosed between 1992 and 2003 into T1 through T4 and then subdivided T1 into 0.01-0.25 mm, 0.26-0.50 mm, 0.51-0.75 mm, and 0.76-1...
November 22, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27886404/adipophilin-expression-in-cutaneous-malignant-melanoma
#6
Masakazu Fujimoto, Ibu Matsuzaki, Yuki Yamamoto, Akihiko Yoshizawa, Kenji Warigaya, Yoshifumi Iwahashi, Fumiyoshi Kojima, Fukumi Furukawa, Shin-Ichi Murata
BACKGROUND: The lipogenic pathway is upregulated in cancer cells, including melanomas. However, the pathological significance of cellular lipids in melanocytic lesions has yet to be determined. In this study, we evaluated intracytoplasmic lipid droplets in melanocytic nevi (MNs) and malignant melanomas via immunohistochemical analysis of adipophilin (ADP), which coats lipid droplets. METHODS: One hundred primary cutaneous melanocytic lesions (33 MNs, 17 melanomas in situ [MIS], and 50 invasive melanomas [IMs]) were immunostained for ADP...
November 25, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27878885/beware-when-the-hair-turns-dark-again-clinical-presentation-and-management-of-melanoma-in-situ-in-a-giant-congenital-naevus-on-the-scalp
#7
Diana Crisan, Karin Scharffetter-Kochanek, Reinhard Dummer, Nicolai Treiber, Anca Sindrilaru, Sabine Kastler, Lars Alexander Schneider
A 74-year-old man presented with a congenital naevus of the scalp that has lost its pigmentation over lifetime. Lately, he noticed a newly darkening patch within the grey hair area covering the naevus. The clinical examination revealed a palm-sized area of heavily pigmented hair on a 15x20 cm irregularly pigmented, poorly demarcated brown patch. This article is protected by copyright. All rights reserved.
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27874206/spitz-nevi-and-other-spitzoid-neoplasms-in-children-overview-of-incidence-data-and-diagnostic-criteria
#8
REVIEW
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Iria Neri, Annalisa Patrizi
Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. A literature search was performed to review the clinical, dermoscopic, genetic, and histopathologic aspects of spitzoid tumors...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27867748/pigmented-bowen-s-disease-presenting-with-a-starburst-pattern
#9
Vincenzo Maione, Enzo Errichetti, Sara Laurent Roussel, Celeste Lebbé
Pigmented Bowen's disease (pBD) is an uncommon in situ squamous cell carcinoma of the skin usually presenting as a dark scaly plaque involving chronically exposed sites, which is not uncommonly mistaken for other similar pigmented lesions, such as melanoma, pigmented basal cell carcinoma or seborrheic keratosis [1,2]. Dermoscopy has been proven to improve its diagnosis by showing several findings, i.e., gray/brownish dots in linear arrangement, scales, coiled vessels, focal/multifocal amorphous hypopigmentation and bluish structureless areas [1,2]...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27867747/early-diagnosis-of-genital-mucosal-melanoma-how-good-are-our-dermoscopic-criteria
#10
Tova Rogers, Melissa Pulitzer, Maria L Marino, Ashfaq A Marghoob, Oliver Zivanovic, Michael A Marchetti
BACKGROUND: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone. CASE: An Asian female in her fifties was referred for evaluation of an asymptomatic, irregularly pigmented patch of the clitoral hood and labia minora of unknown duration...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27864876/kinase-gene-fusions-in-defined-subsets-of-melanoma
#11
Jacqueline Turner, Kasey Couts, Jamie Sheren, Siriwimon Saichaemchan, Witthawat Ariyawutyakorn, Izabela Avolio, Ethan Cabral, Magdelena Glogowska, Carol Amato, Steven Robinson, Jennifer Hintzsche, Allison Applegate, Eric Seelenfreund, Rita Gonzalez, Keith Wells, Stacey Bagby, John Tentler, Aik-Choon Tan, Joshua Wisell, Marileila Varella-Garcia, William Robinson
Genomic rearrangements resulting in activating kinase fusions have been increasingly described in a number of cancers including malignant melanoma, but their frequency in specific melanoma subtypes has not been reported. We used break-apart fluorescence in-situ hybridization (FISH) to identify genomic rearrangements in tissues from 59 patients with various types of malignant melanoma including acral lentiginous, mucosal, superficial spreading, and nodular. We identified four genomic rearrangements involving the genes BRAF, RET, and ROS1...
November 19, 2016: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27862191/significance-of-epidermal-mitoses-in-challenging-melanocytic-proliferations
#12
Eugen C Minca, Steven D Billings, Paul Elson, Michael T Tetzlaff, Aleodor A Andea, Jennifer S Ko
BACKGROUND: Accurate diagnosis of melanoma remains histologically challenging. Dermal mitoses support malignancy, but are only occasionally seen in melanomas. Since melanomagenesis is thought to begin at the dermal-epidermal junction, we investigated the significance of epidermal melanocytic mitoses (EM) in a spectrum of lesions with molecular characterization. METHODS: EM density (EMD) was evaluated in 46 straightforward lesions (24 benign, 22 malignant) and 30 challenging lesions with expert interpretation, fluorescence-in-situ-hybridization, and myPath-score characterization (12 favor-benign, 9 favor-malignant, 9 ambiguous)...
November 15, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27858163/expression-of-piwil3-in-primary-and-metastatic-melanoma
#13
Thilo Gambichler, Christina Kohsik, Ann-Kathrin Höh, Kerstin Lang, Heiko U Käfferlein, Thomas Brüning, Eggert Stockfleth, Markus Stücker, Max Dreißigacker, Michael Sand
PURPOSE: The PIWI-interacting RNA machinery in malignant melanoma (MM) has not been sufficiently studied. We aimed to investigate the PIWIL3 expression profiles in primary melanomas and metastases of MM including a correlation with clinical data. METHODS: We studied 161 primary melanomas, 45 lymph node metastases, and 16 distant metastases of 183 patients with MM. We used immunohistochemistry to assess PIWIL3 protein expression in situ. The relationship between the immunoreactivity of PIWIL3 and clinical data was statistically evaluated...
November 17, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27847622/clinical-application-of-genetic-testing-for-posterior-uveal-melanoma
#14
REVIEW
Victoria J Schopper, Zelia M Correa
Uveal melanoma is the most common primary intraocular tumor in adults, and it has a strong potential to metastasize. Traditionally, clinicopathological features of these tumors were used to provide a limited prediction of the metastatic risk. However, early genetic studies using karyotype analysis, fluorescence in situ hybridization, and comparative genetic hybridization of posterior uveal melanoma samples identified multiple chromosomal abnormalities associated with a higher risk of fatal metastasis. This correlation between specific genetic abnormalities in uveal melanoma and a patient's risk for development of metastasis has recently been widely studied, and the development of new prognostic tests has allowed clinicians to predict this metastatic risk with increased accuracy...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27843900/separate-primary-melanomas-of-the-bulbar-conjunctiva-and-eyelid-skin-clinical-implications-of-multiple-primary-melanomas
#15
Frances A Jacinto, George H Fisher, Edgar M Espana, Ilya M Leyngold, Curtis E Margo
PURPOSE: We report a patient with previous in situ melanoma of the forehead skin who was referred for treatment of a bulbar conjunctival melanoma and a separate superficially invasive melanoma of the eyelid skin, and we offer a review of the biological and clinical implications of patients who have multiple primary melanomas. METHODS: This article offers a clinicopathological correlation with a review of the relevant literature. RESULTS: An 80-year-old white man was referred for evaluation of a suspicious conjunctival tumor and a lower-eyelid lesion...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27831532/multifocal-invasive-ductal-cancer-distinguishing-independent-tumor-foci-from-multiple-satellites
#16
Melissa Alexander, Gabriel Acosta Gonzalez, Stefano Malerba, Tsivia Hochman, Judith D Goldberg, Farbod Darvishian
Patients with multifocal breast cancers (MBCs) have a poorer prognosis than patients with unifocal breast cancers. Studies have attributed this to tumor size underestimation in MBC. An alternative hypothesis is that some MBCs behave in a fashion analogous to the "satellite" and "in-transit metastasis" observed in melanoma and, thereby, are more clinically aggressive. We identified 79 cases of MBC, which we classified into 2 groups: study cases defined as ≥2 morphologically similar tumor foci with ≥1 focus without in situ carcinoma (n = 21); and a control group defined as ≥2 morphologically similar or dissimilar foci with associated in situ carcinoma in all foci (n = 58)...
November 9, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27829101/clinical-features-associated-with-individuals-at-higher-risk-of-melanoma-a-population-based-study
#17
Caroline G Watts, Christine Madronio, Rachael L Morton, Chris Goumas, Bruce K Armstrong, Austin Curtin, Scott W Menzies, Graham J Mann, John F Thompson, Anne E Cust
Importance: The identification of a subgroup at higher risk of melanoma may assist in early diagnosis. Objective: To characterize melanoma patients and the clinical features associated with their melanomas according to patient risk factors: many nevi, history of previous melanoma, and family history of melanoma, to assist with improving the identification and treatment of a higher-risk subgroup. Design, Setting, and Participants: The Melanoma Patterns of Care study was a population-based observational study of physicians' reported treatment of 2727 patients diagnosed with an in situ or invasive primary melanoma over a 12-month period from October 2006 to 2007 conducted in New South Wales...
November 9, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27822097/the-danish-melanoma-database
#18
REVIEW
Lisbet Rosenkrantz Hölmich, Siri Klausen, Eva Spaun, Grethe Schmidt, Dorte Gad, Inge Marie Svane, Henrik Schmidt, Henrik Frank Lorentzen, Else Helene Ibfelt
AIM OF DATABASE: The aim of the database is to monitor and improve the treatment and survival of melanoma patients. STUDY POPULATION: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma Database (DMD). In 2014, 2,525 patients with invasive melanoma and 780 with in situ tumors were registered. The coverage is currently 93% compared with the Danish Pathology Register. MAIN VARIABLES: The main variables include demographic, clinical, and pathological characteristics, including Breslow's tumor thickness, ± ulceration, mitoses, and tumor-node-metastasis stage...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27821803/oncolytic-adenovirus-coexpressing-interleukin-12-and-shvegf-restores-antitumor-immune-function-and-enhances-antitumor-efficacy
#19
Hyo Min Ahn, Jin Woo Hong, Chae-Ok Yun
Tumor microenvironment is extremely immunosuppressive, preventing efficient induction of antitumor immunity. To overcome tumor-mediated immunosuppression and enhance the potency of immunogene therapy, oncolytic adenovirus (Ad) co-expressing interleukin (IL)-12 and vascular endothelial growth factor (VEGF)-specific short hairpin ribonucleic acid (shVEGF; RdB/IL12/shVEGF) was generated. Intratumoral injection of RdB/IL12/shVEGF induced a strong antitumor effect in an immune competent B16-F10 melanoma model. RdB/IL12/shVEGF restored immune surveillance function in tumor tissues and actively recruited immune cells by elevating the expression levels of IL-12 and interferon-γ...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27790747/two-cases-of-seborrheic-keratosis-with-basal-clear-cells
#20
Takashi Anan, Takaya Fukumoto, Tetsunori Kimura
Seborrheic keratosis with basal clear cells (SKBCC) is an extremely rare histopathological variant of seborrheic keratosis that has histological similarities to melanoma in situ. We herein report two cases of SKBCC and provide the first description of the dermoscopic features of this condition, in addition to the histopathological findings. Both of the two lesions showed typical histological architectures of seborrheic keratosis with rows or focal clusters of monomorphic clear cells with abundant pale cytoplasm and small round nucleus in the basal layer...
October 28, 2016: Journal of Dermatology
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