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Melanoma in situ

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https://www.readbyqxmd.com/read/29445579/patient-with-confirmed-leopard-syndrome-developing-multiple-melanoma
#1
Caroline Colmant, Deborah Franck, Liliane Marot, Gert Matthijs, Yves Sznajer, Sandrine Blomme, Isabelle Tromme
LEOPARD syndrome, also known as Gorlin syndrome II, cardiocutaneous syndrome, lentiginosis profusa syndrome, Moynahan syndrome, was more recently coined as Noonan syndrome with multiple lentigines (NSML), inside the RASopathies. Historically, the acronym LEOPARD refers to the presence of distinctive clinical features such as: lentigines (L), electrocardiographic/conduction abnormalities (E), ocular hypertelorism (O), pulmonary stenosis (P), genital abnormalities (A), retardation of growth (R), and sensorineural deafness (D)...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29438650/updated-evidence-based-clinical-practice-guidelines-for-the-diagnosis-and-management-of-melanoma-definitive-excision-margins-for-primary-cutaneous-melanoma
#2
Michael J Sladden, Omgo E Nieweg, Julie Howle, Brendon J Coventry, John F Thompson
Definitive management of primary cutaneous melanoma consists of surgical excision of the melanoma with the aim of curing the patient. The melanoma is widely excised together with a safety margin of surrounding skin and subcutaneous tissue, after the diagnosis and Breslow thickness have been established by histological assessment of the initial excision biopsy specimen. Sentinel lymph node biopsy should be discussed for melanomas ≥ 1 mm thickness (≥ 0.8 mm if other high risk features) in which case lymphoscintigraphy must be performed before wider excision of the primary melanoma site...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29430695/immunocryosurgery-as-monotherapy-for-lentigo-maligna-or-combined-with-surgical-excision-for-lentigo-maligna-melanoma
#3
Clara Matas-Nadal, Xavier Sòria, María R García-de-la-Fuente, Valentín Huerva, Eugenia Ortega, Felip Vilardell, Sònia Gatius, Josep M Casanova, Rosa M Martí
The incidence of lentigo maligna (LM), in situ (LM) or invasive (lentigo maligna melanoma, LMM), has increased during the last decades. Due to functional or cosmetic outcomes, optimal treatment with surgical excision may not be appropriate in some cases. We tried less invasive therapy, immunocryosurgery, as a single treatment for LM or combined with surgery for LMM, with better aesthetic results. Three patients with LM or LMM not amenable to complete surgical excision were selected. LMM patients underwent limited surgical resection of the invasive area...
February 11, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29420887/glutathione-s-transferase-%C3%AF-activatable-o2-sulfonylethyl-derived-diazeniumdiolates-potently-suppress-melanoma-in-vitro-and-in-vivo
#4
Zhangjian Huang, Jianbing Wu, Yu Zou, Haoliang Yuan, Yinqiu Zhang, Yue Fei, Atul Bhardwaj, Jatinder Kaur, Edward E Knaus, Yihua Zhang
A group of glutathione S-transferase π (GSTπ)-activatable O2-(sulfonylethyl derived)diazeniumdiolates 5-12 were designed and synthesized. These compounds could be activated by GSTπ to initiate the β-elimination reaction, liberating an active vinyl sulfone-based GSH derivative and a diazeniumdiolate anion which subsequently releases NO in situ. The most active compound 6 released relatively high levels of NO and inhibited proliferation of melanoma B16 cells, superior to a diazeniumdiolate-based anticancer agent JS-K (1)...
February 8, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29419913/variation-in-the-diagnosis-and-clinical-management-of-lentigo-maligna-across-europe-a-survey-study-among-eadv-members
#5
D Tio, C A C Prinsen, B Dréno, R Hoekzema, M Augustin, C van Montfrans
BACKGROUND: Lentigo maligna (LM), a form of melanoma in situ, is treated to prevent progression to lentigo maligna melanoma (LMM). Surgical treatment is the gold standard. However, treatment guidelines are based on expert opinion and comparative studies are lacking. OBJECTIVE: The objective of this study is to assess the diagnostic methods and clinical management of LM patients among European dermatologists and residents. METHODS: A survey consisting of 29 questions about diagnostic methods and treatment options used for LM patients was sent to 3308 members of the European association of Dermatologists and Venereologists (EADV)...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29419543/evaluation-of-mitf-sox10-mart-1-and-r21-immunostaining-for-the-diagnosis-of-residual-melanoma-in-situ-on-chronically-sun-damaged-skin
#6
Euphemia W Mu, Nicola A Quatrano, Sarah E Yagerman, Desiree Ratner, Shane A Meehan
BACKGROUND: Melanocytic immunostains can assist in margin evaluation of melanoma in situ (MIS) excisions; however, their accuracy and reliability relative to hematoxylin & eosin (H&E) is yet to be determined. OBJECTIVE: The objective of this study was to evaluate the sensitivity, specificity, and concordance of 4 melanocyte-specific immunostains for diagnosing MIS occurring on chronically sun-damaged skin. MATERIALS AND METHODS: Serial permanent sections from representative areas of negative margin and residual tumor were stained using H&E, MITF, MART-1, SOX10, and R21 and examined in a blinded fashion...
February 6, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29417221/reevaluation-of-established-and-new-criteria-in-differential-diagnosis-of-spitz-nevus-and-melanoma
#7
A Ritter, M Tronnier, B Vaske, C Mitteldorf
The histopathologic differentiation between Spitz nevus and melanoma is of particular interest in routine diagnostic procedures of melanocytic tumors. Atypical Spitz nevi are sometimes difficult to distinguish from melanoma. There is still no single criterion that ensures a distinction of melanoma and atypical Spitz nevus. The aim of this study was to reevaluate established and new criteria to differentiate Spitz nevus from melanoma more reliably. We analyzed 25 melanomas with a Breslow index ≥ 1 mm and 18 classical compound Spitz nevi concerning their histopathologic, immunohistochemical and molecular genetic characteristics...
February 7, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29413289/enhancing-radiation-therapy-through-cherenkov-light-activated-phototherapy
#8
Suk W Yoon, Vadim Tsvankin, Zachary Shrock, Boyu Meng, Xiaofeng Zhang, Mark Dewhirst, Peter Fecci, Justus Adamson, Mark Oldham
PURPOSE: This work investigates a new approach to enhance radiotherapy through a photo therapeutic agent activated by Cherenkov light produced from the megavoltage photon beam. The process is termed Radiotherapy Enhanced with Cherenkov photo-Activation (RECA). RECA is compatible with various photo-therapeutics, but here we focus on use with psoralen, an ultraviolet activated therapeutic with extensive history of application in superficial and extracorporeal settings. RECA has potential to extend the scope of psoralen treatments beyond superficial to deep seated lesions...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29406397/isolation-and-characterization-of-circulating-melanoma-cells-by-size-filtration-and-fluorescent-in-situ-hybridization
#9
Masahiko Yanagita, Jason J Luke, Frank S Hodi, Pasi A Jänne, Cloud P Paweletz
Isolation of circulating tumor cells (CTCs) from blood of melanoma patients has been difficult owing to inconsistent expression of surface antigens. Here we report on the isolation, detection, and characterization of CTCs from blood of melanoma patients using microfiltration and fluorescent in-situ hybridization (FISH). Two tubes of blood from 15 patients with advanced melanoma were collected. These two tubes subsequently underwent filtration through a membrane with pore sizes of 7.5 μm. Isolated cells from one tube were analyzed by FISH for RREB1 (6p24), MYB (6q32), SE6 (D6Z1), and CCND1 (11q13) and the other paired specimen was analyzed by immunofluorescence for HMB45, melanoma-associated antigen recognized by T cells-1, tyrosinase and melanogenesis associated transcription factor...
February 5, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29398454/melanoma-in-the-very-elderly-management-in-patients-85years-of-age-and-over
#10
Matthew J Rees, Henry Liao, John Spillane, David Speakman, Chris McCormack, Simon Donahoe, Miki Pohl, Angela Webb, David Gyorki, Michael A Henderson
OBJECTIVES: Melanoma treatment in the elderly can entail complex decision making. This study characterizes the presentation, management, and outcome of melanoma in the very elderly. METHOD: Retrospective review of all patients in their 85th year or older presenting to a tertiary referral cancer centre between 2000 and 2012 with American Joint Committee on Cancer stages 0-II cutaneous melanoma. RESULTS: 127 patients, 26 with in-situ disease and 101 with stages I-II disease, were included...
February 2, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29395684/trends-in-incidence-of-thick-thin-and-in-situ-melanoma-in-europe
#11
L Sacchetto, R Zanetti, H Comber, C Bouchardy, D H Brewster, P Broganelli, M D Chirlaque, D Coza, J Galceran, A Gavin, M Hackl, A Katalinic, S Larønningen, M W J Louwman, E Morgan, T E Robsahm, M J Sanchez, L Tryggvadóttir, R Tumino, E Van Eycken, S Vernon, V Zadnik, S Rosso
BACKGROUND: We analysed trends in incidence for in situ and invasive melanoma in some European countries during the period 1995-2012, stratifying for lesion thickness. MATERIAL AND METHODS: Individual anonymised data from population-based European cancer registries (CRs) were collected and combined in a common database, including information on age, sex, year of diagnosis, histological type, tumour location, behaviour (invasive, in situ) and lesion thickness. Mortality data were retrieved from the publicly available World Health Organization database...
January 30, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29388348/benign-and-malignant-collision-tumors-of-melanocytic-skin-lesions-with-hemangioma-dermoscopic-and-reflectance-confocal-microscopy-features
#12
L Tognetti, E Cinotti, J L Perrot, M Campoli, M Fimiani, P Rubegni
BACKGROUND: Though the combination/collision of nevi or lentigo simplex and hemangiomas is frequent, the malignant collision tumor melanoma-hemangioma is exceptional and can sometime clinically simulate a benign collision. To date, a series of collision tumors of hemangiomas associated with either benign or malignant melanocytic skin lesions (MSL) has yet to be studied by non-invasive imaging and clinico-pathologic correlates. METHODS: We present 10 cases of patients with collision tumors of hemangioma with different MSL including: 2 in situ lentigo-maligna melanoma, 1 invasive melanoma, 5 melanocytic nevi, and 2 lentigo simplex...
January 31, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29386830/early-detection-of-subungual-melanoma-in-situ-proposal-of-abcd-strategy-in-clinical-practice-based-on-case-series
#13
Jae Ho Lee, Ji-Hye Park, Jong Hee Lee, Dong-Youn Lee
Background: Prevalence of subungual melanoma (SUM) in Asian population is relatively high and early clinical detection improves both quality of life and survival. Objective: We sought to establish screening strategy for SUM in situ. Methods: We retrospectively reviewed medical records of 8 patients pathologically diagnosed as SUM in situ between January 2015 and September 2016. Results: All patients in our study were adults and had solitary lesion...
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29377259/a-quantitative-comparison-between-sox10-and-mart-1-immunostaining-to-detect-melanocytic-hyperplasia-in-chronically-sun-damaged-skin
#14
Sonal Muzumdar, Melissa Argraves, Arni Kristjansson, Katalin Ferenczi, Soheil S Dadras
Histologic differentiation of melanoma in situ (MIS) from solar keratosis on chronically sun-damaged skin is challenging. The first-line immunostain is usually MART-1/Melan-A, which can exaggerate the epidermal melanocytes, causing a diagnostic pitfall for MIS. By comparing MART-1 and SOX10 immunostaining, we scored the percentage of epidermal melanocytes per 2-mm diameter fields in pigmented actinic keratosis (n=16), lichenoid keratosis (n=7), junctional melanocytic nevus (n=6), keratosis with atypical melanocytic proliferation (AMP, n=17) and MIS (n=10)...
January 26, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29371009/genetic-background-of-iris-melanomas-and-iris-melanocytic-tumors-of-uncertain-malignant-potential
#15
Natasha M van Poppelen, Jolanda Vaarwater, Hardeep S Mudhar, Karen Sisley, Ian G Rennie, Paul Rundle, Tom Brands, Quincy C C van den Bosch, Hanneke W Mensink, Annelies de Klein, Emine Kiliç, Robert M Verdijk
PURPOSE: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body or choroidal melanoma. The aim of this study was to gain more insight into the genetic background of iris melanoma and iris nevi. DESIGN: Multicenter, retrospective case series. PARTICIPANTS: Patients diagnosed with iris melanoma or iris nevi who underwent surgical intervention as primary or secondary treatment...
January 19, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29355898/in-vivo-dermoscopic-and-confocal-microscopy-multi-step-algorithm-to-detect-in-situ-melanomas
#16
S Borsari, R Pampena, E Benati, C Bombonato, K Athanassios, E Moscarella, A Lallas, G Argenziano, G Pellacani, C Longo
BACKGROUND: Although several dermoscopic features of in situ melanoma (MIS) have been identified, data on confocal features for MIS are still lacking. OBJECTIVES: To identify RCM (reflectance confocal microscopy) features of MIS and to develop a diagnostic score for MIS while combining dermoscopy and RCM. METHODS: 120 MIS and 213 nevi (test set) were retrospectively analysed to assess the presence of dermoscopic and RCM criteria. Facial and acral lesions have been excluded...
January 21, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29352946/redox-enzyme-sensitive-chondroitin-sulfate-based-self-assembled-nanoparticles-loading-docetaxel-for-the-inhibition-of-metastasis-and-growth-of-melanoma
#17
Mengrui Liu, Hongliang Du, Abdur Rauf Khan, Jianbo Ji, Aihua Yu, Guangxi Zhai
In this report, redox/enzyme responsive chondroitin sulfate-ss-deoxycholic acid (CSCD) conjugates were synthesized using cystamine as the linkage which could self-assemble to form self-assembled nanoparticles (175.6 + 5.2 nm) in the aqueous environment. Docetaxel (DTX) was loaded in nanoparticles with desired loading efficiency for the inhibition of tumor growth and metastasis of melanoma. Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29350666/melanoma-in-situ-mimicking-a-lichen-planus-like-keratosis
#18
Andrea Sisti, Amgiad Fallaha, Juri Tassinari, Giuseppe Nisi, Luca Grimaldi, Klaus Eisendle
The incidence of melanoma has steadily increased over the past three decades. Melanoma in situ (MIS),  defined as melanoma that is limited to the epidermis, contributes to a disproportionately high percentage of this rising incidence. Amelanotic melanoma presents as an erythematous macule or plaque and may initially be misdiagnosed as an inflammatory disorder. We report a case of amelonatic MIS raised on non-sun-exposed skin, inducing a lichen planus-like keratosis as inflammatory reaction, which clinically masked the melanoma...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29344493/comparison-of-gene-expression-profiling-and-chromosome-3-analysis-by-fluorescent-in-situ-hybridization-and-multiplex-ligation-probe-amplification-in-fine-needle-aspiration-biopsy-specimens-of-uveal-melanoma
#19
Michael A Klufas, Elizabeth Richter, Sujit Itty, Christian Moreno, Colin A McCannel, Tara A McCannel
Purpose: The aim of this paper was to assess the concordance between results of DecisionDx-UM specific gene expression profiling (GEP) and fluorescence in situ hybridization (FISH) for chromosome 3 analysis, and between DecisionDx-UM GEP and multiplex ligation probe amplification (MLPA) in uveal melanoma undergoing intraoperative fine-needle aspiration biopsy (FNAB) for metastatic prognostication during brachytherapy. Methods: We retrospectively reviewed consecutive patients diagnosed with posterior uveal melanoma who underwent intraoperative FNAB prior to placement of an iodine-125 radioactive plaque between 2012 and 2014...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29337844/melanoma-of-the-skin-in-the-danish-cancer-registry-and-the-danish-melanoma-database-a-validation-study
#20
Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Siri Klausen, Anton Pottegård, Søren Friis, Lisbet Rosenkrantz Hölmich, David Gaist
BACKGROUND: The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. METHODS: We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n=200) and the Melanoma Database (n=200) during 2004-2014, using the Danish Pathology Registry as 'gold-standard' reference...
January 15, 2018: Epidemiology
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