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Jin Zhang, Paloma Valverde, Xiaofang Zhu, Dana Murray, Yuwei Wu, Liming Yu, Hua Jiang, Michel M Dard, Jin Huang, Zhiwei Xu, Qisheng Tu, Jake Chen
Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain-containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue (WAT) and uncoupling protein 1 (UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo...
2017: Bone Research
K P Fung, Q B Han, M Ip, X S Yang, C Bs Lau, B Cl Chan
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
A Wn Leung, M Ip, C S Xu, X N Wang, P T Yung, H Y Hua
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Nasiara Karim, Imran Khan, Naveed Ahmad, Muhammad Naveed Umar, Navnath Gavande
BACKGROUND: GABAA receptors have been implicated in the pathophysiology of depression, epilepsy and pain disorders. The purpose of this study was to investigate two novel synthetic flavones, 3'-methoxy-6-methylflavone (3'-MeO6MF) and 3'-hydroxy-6-methylflavone (3'-OH6MF), for their effect on GABAA receptors and subsequently investigate their antidepressant, anticonvulsant and antinociceptive effects. METHODS: Recombinant GABAA receptor subunits were expressed in Xenopus oocytes and a two electrode voltage clamp technique was used for electrophysiological studies...
March 10, 2017: Pharmacological Reports: PR
Jennifer L Cotton, Qi Li, Lifang Ma, Joo-Seop Park, Jiayi Wang, Jianhong Ou, Lihua J Zhu, Y Tony Ip, Randy L Johnson, Junhao Mao
YAP/TAZ are the major mediators of mammalian Hippo signaling; however, their precise function in the gastrointestinal tract remains poorly understood. Here we dissect the distinct roles of YAP/TAZ in endodermal epithelium and mesenchyme and find that, although dispensable for gastrointestinal epithelial development and homeostasis, YAP/TAZ function as the critical molecular switch to coordinate growth and patterning in gut mesenchyme. Our genetic analyses reveal that Lats1/2 kinases suppress expansion of the primitive mesenchymal progenitors, where YAP activation also prevents induction of the smooth muscle lineage through transcriptional repression of Myocardin...
September 19, 2017: Developmental Cell
Shuai Wang, Tao Lin, Wei Chen, Han Chen
The process parameters of the up-flow biological activated carbon filter (UBACF) were optimized in a pilot-scale trial for controlling the precursor of dichloroacetonitrile (DCAN), an emerging nitrogenous disinfection by-product. The experiments were performed using a central composite design (CCD) with the response surface methodology (RSM). The results showed that the removal efficiencies of formation potentials (FP) of DCAN increased from 28.9% to 64.4% with the optimized ozone dose, expansion rate of BAC and backwashing cycle, being scheduled to 1...
September 15, 2017: Chemosphere
Ruizhi Pang, Kaisong Zhang
Thin film nanocomposite reverse osmosis (TFN RO) membranes incorporated with hydrophilic nanoparticles show a potential problem that the salt rejection can not be improved significantly. In this study, novel TFN RO membranes incorporated with hydrophobic fluorinated silica nanoparticles were fabricated to improve the salt rejection. Fluorinated silica nanoparticles were well dispersed in organic phase during the interfacial polymerization (IP) process. The TFN RO membranes were characterized with attenuated total reflectance infra-red, field emission scanning electron microscopy, atomic force microscopy and water contact angle measurements...
September 15, 2017: Journal of Colloid and Interface Science
Aalekhya Reddam, Edward M Mager, Martin Grosell, M Danielle McDonald
The objective of the present study was to determine whether the polycyclic aromatic hydrocarbons (PAHs) associated with the Deepwater Horizon (DWH) oil spill impacted the stress response of teleost fish. The hypothesis was that intraperitoneal (IP) treatment with PAHs associated with the DWH oil spill or waterborne exposure to DWH oil high energy water-accommodated fraction (HEWAF) would result in the downregulation of the stress response of Gulf toadfish, Opsanus beta, a benthic marine teleost fish that resides in the Gulf of Mexico...
August 26, 2017: Aquatic Toxicology
Georg Lorenz, Michael Schmalenberg, Stephan Kemmner, Bernhard Haller, Dominik Steubl, Dang Pham, Anita Schreiegg, Quirin Bachmann, Alina Schmidt, Sandra Haderer, Monika Huber, Susanne Angermann, Roman Günthner, Matthias Braunisch, Christine Hauser, Anna-Lena Reichelt, Julia Matschkal, Yana Suttmann, Philipp Moog, Konrad Stock, Claudius Küchle, Klaus Thürmel, Lutz Renders, Axel Bauer, Marcus Baumann, Uwe Heemann, Peter B Luppa, Christoph Schmaderer
Chronic inflammation contributes to increased mortality in hemodialysis (HD) patients. YKL-40 is a novel marker of inflammation, tissue remodeling, and highly expressed in macrophages inside vascular lesions. Elevated levels of YKL-40 have been reported for HD patients but how it integrates into the proinflammatory mediator network as a predictor of mortality remains elusive. We studied serum YKL-40, Interleukin-6 (IL-6), high-sensitivity C-reactive protein, monocyte chemotactic protein-1 (MCP-1), and interferon-gamma induced protein-10 (IP-10) in 475 chronic hemodialysis patients...
September 20, 2017: Kidney International
Diane M Quinn, Bradley M Weisz, Elizabeth K Lawner
Despite theoretical support for the relationship between disclosure (or "outness") and positive health outcomes for people with concealable stigmatized identities, research using outness to predict health elicits weak to inconsistent relationships. In the current research we argue that it is the need to frequently conceal that predicts negative health consequences, rather than outness. A sample of adults recruited from Amazon's Mechanical Turk reported on mental illness, chronic physical illness, or minority sexual orientation (N = 288) concealment...
September 18, 2017: Social Science & Medicine
Stephanie M Gorka, Katie L Burkhouse, Kaveh Afshar, K Luan Phan
BACKGROUND: Research suggests that enhanced neural reactivity to errors, measured via the error-related negativity (ERN), is relatively unique to internalizing psychopathologies (IPs) and symptom clusters characterized by excessive worry and apprehension. However, no prior study has tested the association between the ERN and IP symptom dimensions in a heterogeneous, clinically representative patient population. The current study was designed to address this gap in the literature and clarify the role of the ERN in an adult IP treatment-seeking patient sample...
September 20, 2017: Depression and Anxiety
Monika Litko, Marcin Berger, Jacek Szkutnik, Ingrid Różyło-Kalinowska
BACKGROUND: The most common temporomandibular joint (TMJ) internal derangement is an abnormal relationship of the disc with respect to the mandibular condyle, articular eminence, and glenoid fossa - disc displacement. OBJECTIVE: The aim of our study is to analyse the correlation between partial/complete disc displacement in the intercuspal position (IP) and its reduction in the open mouth position (OMP) in both oblique-sagittal and coronal plane on magnetic resonance imaging (MRI) in patients with temporomandibular disorders...
September 23, 2017: Journal of Oral Rehabilitation
Long Vu, Viswanath Ragupathy, Sandhya Kulkarni, Chintamani Atreya
BACKGROUND: Human enucleated mature red blood cells (RBCs) contain both mature microRNAs (miRNAs) and mRNAs, and we have previously correlated RBC storage lesion processes such as eryptosis, adenosine 5'-triphosphate loss, and RBC indices with differentially expressed miRNAs. Here we have characterized Argonaute 2 (AGO2)-miRNA complexes in stored mature RBCs as a first step toward understanding their role, if any. STUDY DESIGN AND METHODS: In this report AGO2-bound miRNAs in mature RBCs isolated from RBCs collected from three different healthy donors and stored for 24 hours at 4 to 6°C were identified by anti-AGO2 immunoprecipitation (IP) followed by next-generation sequencing of the RNA isolated from the IP...
September 20, 2017: Transfusion
W Li, R Angel, S-W Kim, K Brady, S Yu, P W Plumstead
A total of 720 straight-run Heritage 56 M × fast feathering Cobb 500F broiler chickens was fed from 11 to 13 d of age to determine the impacts of dietary calcium (Ca), phytate phosphorus (PP), and phytase concentrations on inositol phosphate (IP3-6) profile in different digestive tract (GI) segments. The experiment was a 2 × 2 × 3 randomized block design with 2 Ca (0.7 and 1.0%) and 2 PP (0.23 and 0.34%) concentrations and 3 doses of Buttiauxella sp. phytase (0, 500, and 1,000 FTU/kg). The experiment was replicated in time (block) with 3 replicates per treatment (Trt) of 10 birds per block...
October 1, 2017: Poultry Science
A B Riber, D A Guzman
Injurious pecking (IP) remains one of the major welfare challenges in housing of laying hens worldwide due to the negative consequences it inflicts on animal welfare and economy. One potential solution to reduce IP is the use of dark brooders as the primary heat source during rearing. The objective was to investigate effects of rearing layer chicks with different management strategies and size allowances of dark brooders on IP and production-related traits during rear and lay. Groups of 100 to 103 Isa Warren chicks were reared either with one of 4 brooder types (n = 4 per treatment) or with whole-house heating (control: n = 6)...
October 1, 2017: Poultry Science
Roopam Duvesh, George Puthuran, Kavitha Srinivasan, Venkatesh Rengaraj, S R Krishnadas, Sharmila Rajendrababu, Vijayakumar Balakrishnan, Pradeep Ramulu, Periasamy Sundaresan
PURPOSE: To compare the levels of cytokines and growth factor in aqueous humor of the patients with chronic primary angle closure glaucoma (PACG) and cataract. METHODS: Aqueous humor samples were collected from 19 chronic PACG patients and compared with 14 nonglaucomatous controls presenting for cataract surgery. The levels of 27 cytokines and growth factors were measured in the aqueous samples using multiplex bead immunoassay and compared across groups. RESULTS: Significantly higher levels of interleukin (IL)-8 (p < 0...
September 22, 2017: Current Eye Research
Abhilasha Williams, Laxmisha Chandrashekar, Vivi M Srivastava, Meera Thomas, Saban Horo, Renu George
Incontinentia pigmenti (IP) is a rare X-linked dominant disorder, in which skin lesions distributed along Blaschko's lines appear shortly after birth. Early lesions which are erythematous/bullous evolve over time into warty lesions, hyperpigmented swirls/macules, and atrophic hypopigmented streaks. Clinical features are heterogeneous. Abnormalities of the teeth, nails, hair, eyes, central nervous system, and breast may also be present. While intelligence is generally normal, varied degrees of intellectual disability/developmental delay have been reported...
July 2017: Indian Journal of Pathology & Microbiology
Sylwia Talarek, Joanna Listos, Jolanta Orzelska-Gorka, Anna Serefko, Jolanta Kotlińska
The goal of the present study was to examine the effects of N-methyl-aspartate (NMDA) receptor antagonists-memantine and ketamine and the drugs modifying the NO:cGMP pathway-NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), the endogenous precursor of NO-L-arginine, and the guanylyl cyclase inhibitor-methylene blue (MB) on the development of sensitization to withdrawal signs precipitated after chronic, interrupted treatment with diazepam, a benzodiazepine receptor agonist, in mice. To develop the sensitization, the mice were divided into groups: continuously and sporadically (with two diazepam-free periods) treated with diazepam (15 mg/kg, sc)...
September 21, 2017: Neurotoxicity Research
Feng Wang, Yang Yang, Shenqing Wang, Haihong Chen, Dehui Wang, Qinying Wang
The aim of this study is to evaluate the efficacy of endoscopic treatment for maxillary inverted papilloma (IP) through partial medial maxillectomy with an inferior turbinate reversing approach. A retrospective analysis of patients treated in our institution for maxillary sinus IP between July 2011 and August 2015 was performed. Demographics, operative technique, characteristics of tumors, complications, postoperative follow-up, and recurrence were evaluated. Twenty-two patients were enrolled in the study. All tumor attachments were identified intraoperatively...
September 21, 2017: European Archives of Oto-rhino-laryngology
I Russel Lee, Ethel Sng, Kok-Onn Lee, James S Molton, Monica Chan, Shirin Kalimuddin, Ezlyn Izharuddin, David C Lye, Sophia Archuleta, Yunn-Hwen Gan
The major risk factor for Klebsiella liver abscess (KLA) is type 2 diabetes mellitus (DM), but the immunological mechanisms involved in the increased susceptibility are poorly defined. We investigated the responses of neutrophils and peripheral blood mononuclear cells (PBMCs) to hypervirulent Klebsiella pneumoniae (hvKP), the causative agent of KLA. DNA and myeloperoxidase levels were elevated in the plasma of KLA patients compared to uninfected individuals indicating neutrophil activation, but diabetic status had no effect on these neutrophil extracellular trap (NET) biomarkers in both subject groups...
2017: Frontiers in Cellular and Infection Microbiology
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