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https://www.readbyqxmd.com/read/29791754/atp-triggers-a-robust-intracellular-ca-2-mediated-signalling-pathway-in-human-synovial-fibroblasts
#1
Kondo C, R B Clark, T Y Kim, Belke D, Banderali U, R T Szerencsei, A H Jalloul, P P M Schnetkamp, Spitzer Kw, Giles Wr
NEW FINDINGS: What is the central question of this study? In human articular joints, the synovial fibroblast HSF cell population has essential functions including secretion of lubricants. We address some remaining questions concerning activation-secretion coupling by characterizing the main [Ca2+ ]i signalling pathways activated by ATP. What is the main finding and its importance? In HSF ATP acts through a linked G-protein (Gq ) and phospholipase C signalling mechanisms to produce IP-3 which markedly enhances release of Ca2+ from the endoplasmic reticulum...
May 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29791183/a-2-year-prospective-cohort-study-of-overuse-running-injuries-the-runners-and-injury-longitudinal-study-trails
#2
Stephen P Messier, David F Martin, Shannon L Mihalko, Edward Ip, Paul DeVita, D Wayne Cannon, Monica Love, Danielle Beringer, Santiago Saldana, Rebecca E Fellin, Joseph F Seay
BACKGROUND: The National Center for Injury Prevention and Control, noting flaws in previous running injury research, called for more rigorous prospective designs and comprehensive analyses to define the origin of running injuries. PURPOSE: To determine the risk factors that differentiate recreational runners who remain uninjured from those diagnosed with an overuse running injury during a 2-year observational period. STUDY DESIGN: Cohort study; Level of evidence, 2...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29789884/biosphere-reserve-for-all-potentials-for-involving-underrepresented-age-groups-in-the-development-of-a-biosphere-reserve-through-intergenerational-practice
#3
Tamara Mitrofanenko, Julia Snajdr, Andreas Muhar, Marianne Penker, Elisabeth Schauppenlehner-Kloyber
Stakeholder participation is of high importance in UNESCO biosphere reserves as model regions for sustainable development; however, certain groups remain underrepresented. The paper proposes Intergenerational Practice (IP) as a means of involving youth and elderly women and explores its options and barriers, using the example of the Salzburger Lungau and Kärntner Nockberge Biosphere Reserve in Austria. Case study analysis is used involving mixed methods. The results reveal obstacles and motivations to participating in biosphere reserve implementation and intergenerational activities for the youth and the elderly women and imply that much potential for IP exists in the biosphere reserve region...
May 22, 2018: Environmental Management
https://www.readbyqxmd.com/read/29789775/pathological-internet-use-an-important-comorbidity-in-child-and-adolescent-psychiatry-prevalence-and-correlation-patterns-in-a-naturalistic-sample-of-adolescent-inpatients
#4
Martin Fuchs, David Riedl, Astrid Bock, Gerhard Rumpold, Kathrin Sevecke
Background: Few studies have examined the prevalence of problematic internet use (PIU) in young people undergoing inpatient treatment in child and adolescent psychiatry centers. The aims of our study were thus (a) to assess the frequency of comorbid PIU in a sample of adolescent psychiatric inpatients and compare it with a control group of nonreferred adolescents and (b) to gain insights into correlations between PIU and psychiatric comorbidities. Methods: 111 child and adolescent psychiatry inpatients (CAP-IP, mean age 15...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789232/high-grade-serous-ovarian-cancer-use-of-machine-learning-to-predict-abdominopelvic-recurrence-on-ct-on-the-basis-of-serial-cancer-antigen-125-levels
#5
Atul B Shinagare, Patricia Balthazar, Ivan K Ip, Ronilda Lacson, Joyce Liu, Nikhil Ramaiya, Ramin Khorasani
PURPOSE: The aim of this study was to use machine learning to predict abdominal recurrence on CT on the basis of serial cancer antigen 125 (CA125) levels in patients with advanced high-grade serous ovarian cancer on surveillance. METHODS: This institutional review board-approved, HIPAA-compliant, retrospective, hypothesis-generating study included all 57 patients (mean age, 61 ± 11.2 years) with advanced high-grade serous ovarian cancer who underwent cytoreductive surgery from January to December 2012, followed by surveillance abdominopelvic CT and corresponding CA125 levels...
May 19, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29788817/inducible-nitric-oxide-inhibitor-aminoguanidine-ameliorated-oxidative-stress-interleukin-6-concentration-and-improved-brain-derived-neurotrophic-factor-in-the-brain-tissues-of-neonates-born-from-titanium-dioxide-nanoparticles-exposed-rats
#6
Amir Asghari, Mahmoud Hosseini, Farimah Beheshti, Mohammad Naser Shafei, Soghra Mehri
INTRODUCTION: An interaction between oxidative stress, neuroinflammation and nitric oxide (NO) has been suggested to have a role neurotoxicity. The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress and interleukin-6 (IL-6) concentrations in the brain tissues of neonates born from the rats exposed to titanium dioxide nanoparticles (TiO2 NPs) during gestation was...
May 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29788544/cochlear-implantation-using-a-custom-guide-catheter-in-fourteen-patients-with-incomplete-partition-type-iii
#7
Hao Tian, Line Wang, Fenqi Gao, Wenqi Liang, Kevin A Peng
Incomplete partition type III (IP-III), also termed X-linked deafness with stapes gusher, is a heterogeneous condition that predominantly affects males; however, females demonstrating the phenotype also exist. The absence of a bony partition between the fundus of the internal auditory canal (IAC) and cochlea predisposes these patients to cerebrospinal fluid leak or electrode passage into the IAC when performing cochlear implantation. We describe a surgeon-fabricated guide catheter, made intraoperatively from a 16-gauge intravenous catheter, that helps avoid electrode passage into the IAC during CI for patients with IP-III...
May 22, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29788075/effects-of-immunonutrition-in-advanced-hiv-disease-a-randomized-placebo-controlled-clinical-trial-promaltia-study
#8
Sergio Serrano-Villar, María de Lagarde, Jorge Vázquez-Castellanos, Alejandro Vallejo, J Ignacio Bernadino, Nadia Madrid, Mariano Matarranz, Alberto Díaz-Santiago, Carolina Gutiérrez, Alfonso Cabello, Judit Villar-García, José Ramón Blanco, Otilia Bisbal, Talía Sainz, Andrés Moya, Santiago Moreno, María José Gosalbes, Vicente Estrada
Background: While nutritional interventions with prebiotics and probiotics seem to exert immunological effects, their clinical implications in HIV-infected subjects initiating ART at advanced HIV disease remain unclear. Methodology: Pilot multicenter randomized, placebo-controlled, double-blind study in which 78 HIV-infected, ART-naive subjects with <350 CD4 T-cells/µl or AIDS were randomized to either daily PMT25341 (a mixture of prebiotics, probiotics, oligonutrients, DHA, EPA, GLA, and aminoacids) or placebo for 48 weeks, each in combination with first-line ART...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29787994/bioavailability-of-wilforlide-a-in-mice-and-its-concentration-determination-using-an-hplc-apci-ms-ms-method
#9
Zhijun Wang, Steven Yeung, Shang Chen, Yasmin Moatazedi, Moses S S Chow
Wilforlide A (WA), an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases, is a quality control marker for TW product. At present, the bioavailability/pharmacokinetics of WA is not known. Such information is not only essential to evaluate the relevance of WA as a quality control maker, but also important for future clinical efficacy studies. Therefore, a high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometric method (HPLC-APCI-MS/MS) was developed and applied to a bioavailability/pharmacokinetic study of WA...
May 16, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29785939/exploring-an-integrative-patient-tailored-complementary-medicine-approach-for-chemotherapy-induced-taste-disorders
#10
Eran Ben-Arye, Ilana Doweck, Elad Schiff, Noah Samuels
CONTEXT: Chemotherapy-induced taste disorder (CITD) is a common adverse effect among patients with cancer, with no effective known treatment. OBJECTIVES: Exploring the impact of a patient-tailored complementary and integrative medicine (CIM) treatment program on CITD-related severity. DESIGN: Prospective study on patients' chart. SETTING: Integrative oncology program operating within the Clalit Healthcare Oncology Service in northern Israel...
April 22, 2018: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29785914/fermented-camel-milk-prevents-carbon-tetrachloride-induced-acute-injury-in-kidney-of-mice
#11
Houda Hamed, Manel Gargouri, Salha Boulila, Fatma Chaari, Ferdaws Ghrab, Rim Kallel, Zied Ghannoudi, Tahia Boudawara, Semia Chaabouni, Abdelfattah El Feki, Ahmed Gargouri
Fermented milk is known to possess potent antioxidant activity. The present study was undertaken to assess the preventive effect of fermented camel milk (FCM) prepared using lactococcus lactis subsp. cremoris against CCl4 induced kidney damage in mice. Nephrotoxicity was induced in mice by a single dose of CCl4 (10 ml/kg 0·3% olive oil, ip). Female mice were pretreated daily with FCM for 15 d. Renal damage was associated with an increase in oxidative stress parameters (lipid peroxidation, protein carbonyl and changes in antioxidant enzyme activities and non-enzymatic antioxidant) and nephropathology markers...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29785355/identification-and-expression-analysis-of-cytokinin-metabolic-genes-ipts-cyp735a-and-ckxs-in-the-biofuel-plant-jatropha-curcas
#12
Li Cai, Lu Zhang, Qiantang Fu, Zeng-Fu Xu
The seed oil of Jatropha curcas is considered a potential bioenergy source that could replace fossil fuels. However, the seed yield of Jatropha is low and has yet to be improved. We previously reported that exogenous cytokinin treatment increased the seed yield of Jatropha . Cytokinin levels are directly regulated by isopentenyl transferase (IPT), cytochrome P450 monooxygenase, family 735, subfamily A (CYP735A), and cytokinin oxidase/dehydrogenase (CKX). In this study, we cloned six IPT genes, one JcCYP735A gene, and seven JcCKX genes...
2018: PeerJ
https://www.readbyqxmd.com/read/29785126/impact-of-targeting-transforming-growth-factor-%C3%AE-2-with-antisense-ot-101-on-the-cytokine-and-chemokine-profile-in-patients-with-advanced-pancreatic-cancer
#13
Osmond J D'Cruz, Sanjive Qazi, Larn Hwang, Kevin Ng, Vuong Trieu
Background: Overexpression of the cytokine - transforming growth factor-beta 2 (TGF-β2) - has been implicated in the malignant progression of pancreatic cancer (PAC). OT-101 (trabedersen) is an antisense oligodeoxynucleotide designed to target the human TGF-β2 mRNA. In a Phase I/II study, OT-101 treatment with subsequent chemotherapy was characterized by outstanding overall survival (OS) in patients with PAC. Objective: This study sought to identify 1) co-regulated sets of cyto-/chemokines; 2) potential mechanisms that link TGF-β receptor type 2 receptor inhibition that may result in the induction of a cytokine storm; and 3) predictive biomarkers for OS outcome in OT-101-treated patients with PAC...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29785022/novel-peptide-gx1-inhibits-angiogenesis-by-specifically-binding-to-transglutaminase-2-in-the-tumorous-endothelial-cells-of-gastric-cancer
#14
Zhijie Lei, Na Chai, Miaomiao Tian, Ying Zhang, Guodong Wang, Jian Liu, Zuhong Tian, Xiaofang Yi, Di Chen, Xiaowei Li, Pengfei Yu, Hao Hu, Bing Xu, Chao Jian, Zhenyuan Bian, Hao Guo, Jinpeng Wang, Shiming Peng, Yongzhan Nie, Niu Huang, Sijun Hu, Kaichun Wu
The clinical application of GX1, an optimal gastric cancer (GC) targeting peptide, is greatly limited because its receptor in the GC vasculature is unknown. In this study, we screened the candidate receptor of GX1, transglutaminase-2(TGM2), by co-immunoprecipitation (co-IP) combined with mass spectrometry. We found that TGM2 was up-regulated in GC vascular endothelial cells and that GX1 receptor expression was suppressed correspondingly after TGM2 downregulation. A highly consistent co-localization of GX1 receptor and TGM2 was detected at both the cellular and tissue levels...
May 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29784129/the-non-psychoactive-phytocannabinoid-cannabidiol-cbd-attenuates-pro-inflammatory-mediators-t-cell-infiltration-and-thermal-sensitivity-following-spinal-cord-injury-in-mice
#15
Hongbo Li, Weimin Kong, Christina R Chambers, Daohai Yu, Doina Ganea, Ronald F Tuma, Sara Jane Ward
We evaluated the effects of the non-psychoactive cannabinoid cannabidiol (CBD) on the inflammatory response and recovery of function following spinal cord injury (SCI). Female C57Bl/6 mice were exposed to spinal cord contusion injury (T9-10) and received vehicle or CBD (1.5 mg/kg IP) injections for 10 weeks following injury. The effect of SCI and CBD treatment on inflammation was assessed via microarray, qRT-PCR and flow cytometry. Locomotor and bladder function and changes in thermal and mechanical hind paw sensitivity were also evaluated...
March 8, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29783938/biochemical-and-molecular-characterisation-of-exogenous-cytokinin-application-on-grain-filling-in-rice
#16
Binay Bhushan Panda, Sudhanshu Sekhar, Sushant Kumar Dash, Lamboder Behera, Birendra Prasad Shaw
BACKGROUND: Poor filling of grains in the basal spikelets of large size panicles bearing numerous spikelets has been a major limitation in attempts to increase the rice production to feed the world's increasing population. Considering that biotechnological intervention could play important role in overcoming this limitation, the role of cytokinin in grain filling was investigated based on the information on cell proliferating potential of the hormone and reports of its high accumulation in immature seeds...
May 21, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29783655/gdf11-modulates-ca-2-dependent-smad2-3-signaling-to-prevent-cardiomyocyte-hypertrophy
#17
Javier Duran, Mayarling Francisca Troncoso, Daniel Lagos, Sebastian Ramos, Gabriel Marin, Manuel Estrada
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-β family, has been shown to act as a negative regulator in cardiac hypertrophy. Ca2+ signaling modulates cardiomyocyte growth; however, the role of Ca2+ -dependent mechanisms in mediating the effects of GDF11 remains elusive. Here, we found that GDF11 induced intracellular Ca2+ increases in neonatal rat cardiomyocytes and that this response was blocked by chelating the intracellular Ca2+ with BAPTA-AM or by pretreatment with inhibitors of the inositol 1,4,5-trisphosphate (IP₃) pathway...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29782937/health-disparities-among-children-with-asthma-in-the-u-s-by-place-of-residence
#18
Patrick W Sullivan, Vahram Ghushchyan, Abhishek Kavati, Prakash Navaratnam, Howard S Friedman, B Ortiz
BACKGROUND: Children residing in poor-urban areas may have greater asthma morbidity. It is unclear if this is due to individual characteristics like race and ethnicity or place of residence. OBJECTIVE: Assess indicators of control and treatment by residence. METHODS: This was a cross-sectional analysis of children (aged 1-17) in the 2000-2014 Medical Expenditure Panel Survey (MEPS). Indicators of poor control included use of > 3 canisters of short-acting beta agonist (SABA) in 3 months, asthma attack, and Emergency Department (ED) or inpatient (IP) visit during the year...
May 18, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29782915/new-insights-into-the-natural-course-of-knee-osteoarthritis-early-regulation-of-cytokines-and-growth-factors-with-emphasis-on-sex-dependent-angiogenesis-and-tissue-remodeling-a-pilot-study
#19
Kalle Kisand, Ann Tamm, Mare Lintrop, Agu Tamm
OBJECTIVE: This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease. METHODS: The pilot population study involved 60 middle-aged patients (mean age 50±7.3y.). Standardized weight-bearing anteroposterior and axial radiographs were used to assess rKOA severity in tibiofemoral (TFJ) of patellofemoral joint (PFJ) by grading system (grades 0-3). Luminex (xMAP® ) technology was used to simultaneously assess 60 biomarkers...
May 18, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29782365/utilization-of-an-alternative-docetaxel-based-intraperitoneal-chemotherapy-regimen-in-patients-with-ovarian-fallopian-tube-or-primary-peritoneal-carcinoma-a-continued-need-for-ovarian-cancer-patients
#20
David A Becker, Charles A Leath, Christen L Walters-Haygood, Brentley Q Smith, Kerri S Bevis
OBJECTIVE: The objective of this study was to report the tolerability and toxicity of a regimen consisting of intravenous (IV) docetaxel and intraperitoneal (IP) cisplatin and paclitaxel with granulocyte colony-stimulating factor support. MATERIALS AND METHODS: We conducted a retrospective cohort study of patients with surgical stage II-IV epithelial ovarian, fallopian tube or primary peritoneal carcinoma treated with an outpatient IP chemotherapy regimen consisting of docetaxel 75 mg/m IV and cisplatin 75 mg/m IP day 1 followed by paclitaxel 60 mg/m IP day 8 every 21 days...
May 18, 2018: American Journal of Clinical Oncology
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