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Basal cell carcinoma matrix metalloproteinases

Hamideh Kadeh, Shirin Saravani, Fatemeh Heydari, Saeed Shahraki
Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) are two common skin malignancies with different potentials for invasion and metastasis. The mechanism responsible for various growth patterns observed in SCC and BCC is still not fully understood. The aim of this study was to investigate the expression of matrix metalloproteinase-10 in non-melanoma skin cancers, including BCC and SCC of the head and neck. The study group consisted of 60 specimens, including 30 BCC and 30 cutaneous SCC of the head and neck...
October 2016: Pathology, Research and Practice
Pavida Pittayapruek, Jitlada Meephansan, Ornicha Prapapan, Mayumi Komine, Mamitaro Ohtsuki
Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases with an extensive range of substrate specificities. Collectively, these enzymes are able to degrade various components of extracellular matrix (ECM) proteins. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26); and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, and MMP-16)...
June 2, 2016: International Journal of Molecular Sciences
Hisashi Goto, Yuichi Ishihara, Takeshi Kikuchi, Ario Izawa, Nobuaki Ozeki, Eijiro Okabe, Yosuke Kamiya, Yusuke Ozawa, Hiroki Mizutani, Genta Yamamoto, Makio Mogi, Kazuhiko Nakata, Hatsuhiko Maeda, Toshihide Noguchi, Akio Mitani
Interleukin-1 receptor antagonist (IL-1Ra) is an IL-1 family member, which binds to IL-1 receptors but does not induce any intracellular signaling. We addressed whether IL-1Ra has a novel function in regulation of the extracellular matrix or adhesion molecules. Polymerase chain reaction array analysis demonstrated a ~5-fold increase in matrix metalloproteinase 13 (MMP-13) mRNA expression of IL-1Ra siRNA-transfected Ca9-22 human oral squamous epithelial carcinoma cells compared with the control. In fact, MMP-13 mRNA and protein expression as well as its activity in IL-1Ra siRNA-transfected Ca9-22 cell lines were significantly higher than those in the control...
2015: PloS One
Joseph R McCorkle, Mary K Leonard, Susan D Kraner, Eric M Blalock, Deqin Ma, Stephen G Zimmer, David M Kaetzel
NME1 is a well-documented metastasis suppressor gene, with suppressor activity demonstrated across a wide spectrum of human cancers including melanoma and carcinomas of the breast, stomach and thyroid. A primary aim of the current study was to identify profiles of genes whose expression is regulated by NME1 in cell lines of melanoma and thyroid carcinoma origin. Impact of NME1 was determined by forcing its expression transiently in cell lines using a novel Ad5-based adenoviral vector (Ad5-NME1), followed 48 h later by analysis of RNA expression profiles using the U133A microarray chip...
July 2014: Cancer Genomics & Proteomics
Pernilla von Nandelstadh, Erika Gucciardo, Jouko Lohi, Rui Li, Nami Sugiyama, Olli Carpen, Kaisa Lehti
Basal-like breast carcinomas, characterized by unfavorable prognosis and frequent metastases, are associated with epithelial-to-mesenchymal transition. During this process, cancer cells undergo cytoskeletal reorganization and up-regulate membrane-type 1 matrix metalloproteinase (MT1-MMP; MMP14), which functions in actin-based pseudopods to drive invasion by extracellular matrix degradation. However, the mechanisms that couple matrix proteolysis to the actin cytoskeleton in cell invasion have remained unclear...
September 1, 2014: Molecular Biology of the Cell
Grasieli de Oliveira Ramos, Aline Costa, Maria I Meurer, Daniella S C Vieira, Elena R C Rivero
BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a benign tumor that arises sporadically or associated with nevoid basal cell carcinoma syndrome (NBCCS). Its locally aggressive behavior contrasts with its cystic histological appearance. To better understand the interaction between tumor cells and the stroma, the present study aimed to evaluate and compare the immunohistochemical expression of matrix metalloproteinases (MMP-1, -2, and -9), the cellular proliferation index (Ki-67), and the presence of myofibroblasts (MFs) in KCOTs...
April 2014: Journal of Oral Pathology & Medicine
In-Kee Hong, Hee-Jung Byun, Jaeseob Lee, Young-June Jin, Sun-Ju Wang, Doo-Il Jeoung, Young-Myeong Kim, Hansoo Lee
Despite the importance of multiple tetraspanin proteins in cancer invasion and metastasis, little is known about the role and significance of tetraspanin CD81 in these processes. In the present study, we examined CD81 effects on melanoma cell invasiveness and metastasis. Transfection of CD81 into melanoma cells lacking endogenous CD81 expression significantly enhanced the migrating, invasive, and metastatic abilities of melanoma cells. Interestingly, membrane type 1 matrix metalloproteinase (MT1-MMP) expression was found in CD81-expressing melanoma cells but not in CD81-deficient cells...
May 30, 2014: Journal of Biological Chemistry
Yanli Zhang, Qiuyan Wang, Ailing Ma, Yunhong Li, Rui Li, Yin Wang
The Toll-like receptor 9 (TLR9) plays a crucial role in both innate and adaptive immune responses against infection and danger signals. Stimulation of TLR9 has been linked to invasion in various cancer cells in vitro. The present study evaluated the expression of TLR9 in human esophageal cancer (EC) cells and normal and malignant esophageal squamous epithelium, and examined the association between TLR9 expression, clinicopathological variables, and EC patient outcome. We further characterized the direct effects of TLR9 agonist CpG oligonucleotides (CpG ODN) and inhibitor chloroquine (CQ), on the proliferation and invasion of EC cells in vitro...
May 2014: Oncology Reports
Mohamed A El-Khalawany, Amany A Abou-Bakr
CONTEXT: Recurrence of basal cell carcinoma (BCC) may form a prognostic problem that couldn't be fully predicted. Although there are different clinical and histologic risk factors for BCC recurrence, few reports are available for the role of biologic markers. AIM: The aim of this study was to assess the value of Cyclooxygenase-2 (COX-2), Ezrin and Matrix metalloproteinase-9 (MMP-9) in recurrence of BCC. SETTINGS AND DESIGN: A retrospective controlled study...
October 2013: Journal of Cancer Research and Therapeutics
Lucija Vanjaka-Rogošić, Neira Puizina-Ivić, Lina Mirić, Veljko Rogošić, Ivana Kuzmić-Prusac, Mirna Saraga Babić, Dubravka Vuković, Snježana Mardešić
The immunohistochemical staining of matrix metalloproteinases (MMPs) and E-cadherin in tumor epithelial and stromal cells was analyzed in a group of solid, superficial spreading and cystic tumors and in a group of morpheaform and recurrent basal cell carcinomas (BCC) in order to determine whether any of these factors possibly contribute to tumor therapy resistance. Tumor tissues of 64 patients were obtained by complete excisional or curettage biopsy of BCC and these were immunohistochemically stained for MMP-1, MMP-2, MMP-9, MMP-13 and E-cadherin...
June 2014: Acta Histochemica
Fatmagül Kuşku Cabuk, Seyran Yığıt, Lütfiye Demır, Fulya Cakalağaoğlu, Oktay Tarhan
OBJECTIVE: Pathological stage is the most important prognostic factor in ovarian carcinomas, and many studies have been carried out to predict prognosis. In our study, we searched the expression of survivin, which prevents apoptosis and matrix metalloproteinase-9 (MMP-9), which promotes the metastasis of the tumour by splitting up the basal membrane in primary epithelial ovarian carcinomas. We aimed to observe their effects on prognosis by comparing clinicopathological parameters. MATERIAL AND METHOD: 60 cases diagnosed with epithelial ovarian carcinoma between 2003 and 2008 and treated and followed up at the oncology clinic were included in the study...
2014: Türk Patoloji Dergisi
M E Ciurea, Daniela Cernea, C C Georgescu, O S Cotoi, V Pătraşcu, H Pârvănescu, D Popa, V Pârvănescu, Raluca Niculina Ciurea, R Mercuţ
Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans, accounting for almost 80% of all non-melanoma skin cancers worldwide. The nodular and infiltrative-morpheaform are the most common BCC types in the head and neck region and together with the micronodular subtypes are the most aggressive tumors, because of their tendency to infiltrate the deep subcutis, muscles and even bones. To explain the local aggressive behavior and their metastatic potential, many studies have been performed to identify the molecular determinants implicated in BCC tumor progression...
2013: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Monica Costescu, Oana Andreia Coman, M Tampa, Irina Tudose, L Coman, Simona Roxana Georgescu
Basal cell carcinoma (BCC) is the most common cutaneous cancer. It seems that the most important prognostic factor is exposure to ultraviolet radiation (solar and artificial), correlated with other factors as well. In this article, we aimed to review basal cell carcinoma located in the axilla, referring to cases from our hospital. Axillary location of BCC is rare, with a very low number of cases quoted in the literature, compared to the high prevalence of basal cell carcinoma in the general population. During a period of two years, we detected only four cases of axillary basal cell carcinoma out of a total number of 921 cases diagnosed as BCC...
2013: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Bin-Bin Li, Chuan-Xiang Zhou, Sheng-Nan Jia
Cribriform type of salivary basal cell adenoma (cBCA) is relatively rare and problematic in distinction from adenoid cystic carcinoma (AdCC). The aim of this study was to investigate the clinicopathology and immunoprofile of cBCA. Nineteen cases of cBCA with at least a 30% area of cribriform structure under microscope were analyzed by the description of their histopathologic and immunohistochemical features using the antibodies of matrix metalloproteinase-9 (MMP9), CK8&18, calponin, SMA, S100, P63, CD117, and laminin...
February 2014: Annals of Diagnostic Pathology
C Sterz, R Mandic
BACKGROUND: With a frequency of about 90 %, head and neck squamous cell carcinomas (HNSCCs) are the most common malignancies of the upper aerodigestive tract. The cancer stem cell (CSC) hypothesis postulates that CSCs are the dangerous part of the tumor and are relevant to metastasis, invasiveness and resistance to chemotherapy. METHODS: Tissue samples taken from HNSCCs and normal mucosa were tested for the expression of several established CSC markers. The expression and activity of the matrix metalloproteinase MMP-9 was also investigated...
December 2013: HNO
Fabiano O Poswar, Carlos A C Fraga, Lucyana C Farias, John D Feltenberger, Vitória P D Cruz, Sérgio H S Santos, Christine M Silveira, Alfredo M B de Paula, André L S Guimarães
The expression of metalloproteinases and their inhibitors has been related to different invasive and metastatic potentials in cancer. This study aims to investigate the immunohistochemical expression of TIMP-3 and MMP-9 in samples of basal cell carcinoma (BCC), squamous cell carcinoma of the skin (SCC), and actinic keratosis (AK). Immunohistochemistry was performed to evaluate the expression of TIMP-3 and MMP-9 in samples of BCC (n=22), SCC (n=10), and AK (n=15). Ten fields of both tumor parenchyma and tumor stroma were photographed and counted in image software...
November 2013: Pathology, Research and Practice
Li Zhu, Futoshi Kohda, Takeshi Nakahara, Takahito Chiba, Gaku Tsuji, Junichi Hachisuka, Takamichi Ito, Yating Tu, Yoichi Moroi, Hiroshi Uchi, Masutaka Furue
BACKGROUND: S100 proteins belong to a family of calcium-binding proteins that regulate cell proliferation and differentiation. Despite our growing knowledge about the biology of S100 proteins in some human cancers, little is known about the expression of S100 family members in epidermal tumors and their clinical significance. OBJECTIVE: To determine the expression of S100A2, S100A4, S100A6, S100A7, as well as matrix metalloproteinases 9 (MMP9) in a spectrum of epidermal tumors with benign and malignant characteristics...
December 2013: Journal of Dermatological Science
Frank Götschel, Daniela Berg, Wolfgang Gruber, Christian Bender, Markus Eberl, Myriam Friedel, Johanna Sonntag, Elena Rüngeler, Hendrik Hache, Christoph Wierling, Wilfried Nietfeld, Hans Lehrach, Annemarie Frischauf, Reinhard Schwartz-Albiez, Fritz Aberger, Ulrike Korf
Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene specificity, and oncogenic activity of HH signaling depend profoundly on interactions with other pathways, such as epidermal growth factor receptor-mediated signaling, which has been shown to cooperate with HH/GLI in basal cell carcinoma and pancreatic cancer. Our experimental data demonstrated that the Daoy human medulloblastoma cell line possesses a fully inducible endogenous HH pathway...
2013: PloS One
Joanna Niemiec, Agnieszka Adamczyk, Krzysztof Małecki, Aleksandra Ambicka, Janusz Ryś
BACKGROUND: It is still being discussed if the assessment of basal markers or if adhesion molecules expression contributes additional prognostic information to the classic prognostic factors and hence should be included into standard morphologic reports. PATIENTS AND METHODS: The aim of the study was to assess the prognostic significance of: (i) classification recommended by St Gallen experts (ii) tumor grade, expression of (iii) basal markers, (iv) adhesion molecules, and (v) matrix metalloproteinase 2 (MMP-2) in patients with T1-T2 N0M0 chemotherapy-naive ductal breast cancer...
April 2013: Clinical Breast Cancer
Deepa R Mane, Alka D Kale, Punnya Angadi, Seema Hallikerimath
Basaloid squamous cell carcinoma (BSCC) is rare variant of oral squamous cell carcinoma (OSCC) with predilection for upper aerodigestive tract. Although it is characterized by distinct histologic features it is often confused with conventional OSCC and other basaloid tumors. The study aims to establish differentiating features of BSCC with oral basaloid tumors using immunohistochemical (IHC) markers. This retrospective study included 34 cases, including BSCC, OSCC, and basaloid tumors. IHC staining was performed with primary antibodies against cytokeratin (CK) 19, 14, 8/18, α-smooth muscle actin (αSMA), p53, and MMP-9...
October 2013: Applied Immunohistochemistry & Molecular Morphology: AIMM
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