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Photoaging treatment

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https://www.readbyqxmd.com/read/28551094/a-synthetic-peptide-blocking-trpv1-activation-inhibits-uv-induced-skin-responses
#1
So Min Kang, Sangbum Han, Jang-Hee Oh, Young Mee Lee, Chi-Hyun Park, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
BACKGROUND: Transient receptor potential type 1 (TRPV1) can be activated by ultraviolet (UV) irradiation, and mediates UV-induced matrix metalloproteinase (MMP)-1 and proinflammatory cytokines in keratinocytes. Various chemicals and compounds targeting TRPV1 activation have been developed, but are not in clinical use mostly due to their safety issues. OBJECTIVE: We aimed to develop a novel TRPV1-targeting peptide to inhibit UV-induced responses in human skin. METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr(705), and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin...
May 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28526633/facial-skin-rejuvenation-by-autologous-dermal-microfat-transfer-in-photoaged-patients-clinical-evaluation-and-skin-surface-digital-profilometry-analysis
#2
Angelo Trivisonno, Alfredo Rossi, Massimo Monti, Donato Di Nunno, Christophe Desouches, Claudio Cannistra, Gabriele Toietta
Cumulative long-term exposure to solar ultraviolet radiation promotes premature skin aging characterized by wrinkle formation and reduced skin elasticity. In this study, we assessed whether microfat transfer could improve dermal and subcutaneous tissue thickness loss associated with photoaging. Twenty-one patients affected by facial photoaging (photodamage grade II-IV; age range 35-62 years; 19 females, 2 males; all of Caucasian origin) were treated using minimally invasive autologous dermal white fat transfer harvested with a recently designed microcannula...
April 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28503261/anti-photoaging-effects-of-angelica-acutiloba-root-ethanol-extract-in-human-dermal-fibroblasts
#3
Min Ah Park, Mi Ja Sim, Young Chul Kim
The effects that ultraviolet rays elicit on collagen synthesis and degradation are the most common causes of wrinkle formation and photo-aging in skin. The objectives of this study were to evaluate the effects of Angelica acutiloba root ethanol extract (AAEE) to promote collagen synthesis and inhibit collagen degradation in human dermal fibroblasts. By examining total polyphenol and flavonoid contents, electron donating ability, radical scavenging activity, and superoxide dismutase-like activity, we found that AAEE exhibited fairly good antioxidant activity...
April 2017: Toxicological Research
https://www.readbyqxmd.com/read/28441605/biological-effects-and-medical-applications-of-infrared-radiation
#4
Shang-Ru Tsai, Michael R Hamblin
Infrared (IR) radiation is electromagnetic radiation with wavelengths between 760nm and 100,000nm. Low-level light therapy (LLLT) or photobiomodulation (PBM) therapy generally employs light at red and near-infrared wavelengths (600-100nm) to modulate biological activity. Many factors, conditions, and parameters influence the therapeutic effects of IR, including fluence, irradiance, treatment timing and repetition, pulsing, and wavelength. Increasing evidence suggests that IR can carry out photostimulation and photobiomodulation effects particularly benefiting neural stimulation, wound healing, and cancer treatment...
May 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28434049/a-prospective-study-of-the-safety-and-efficacy-of-a-combined-bipolar-radiofrequency-intense-pulsed-light-and-infrared-diode-laser-treatment-for-global-facial-photoaging
#5
Min Jiang, Fang Yan, Mathew Avram, Zhong Lu
The clinical features of photoaging include: skin texture changes, laxity, rhytides, pigmentary changes, and vascular changes such as erythema and telangiectasias. In order to meet patients' increasing demands for improving all aspects of photoaging at one office visit, employing a multi-modality treatment for all aspects of photoaging has become increasingly desirable for the physician and patient alike. We examine a novel device that employs bipolar radiofrequency (RF), intense pulsed light (IPL), and infrared diode laser...
April 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28425237/the-efficacy-of-narrowband-uvb-treatment-in-pediatricvitiligo-a-retrospective-analysis-of-26-cases
#6
Serkan Yazici, Berrin Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali
BACKGROUND/AIM: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively. MATERIALS AND METHODS: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28404919/paeonol-suppresses-solar-ultraviolet-induced-skin-inflammation-by-targeting-t-lak-cell-originated-protein-kinase
#7
Peipei Xue, Yong Wang, Fanfan Zeng, Ruijuan Xiu, Jingwen Chen, Jinguang Guo, Ping Yuan, Lin Liu, Juanjuan Xiao, Hui Lu, Dan Wu, Huaxiong Pan, Mingmin Lu, Feng Zhu, Fei Shi, Qiuhong Duan
Excessive exposure to solar UV (SUV) is related with numerous human skin disorders, such as skin inflammation, photoaging and carcinogenesis. T-LAK cell- originated protein kinase (TOPK), an upstream of p38 mitogen-activated protein kinase (p38) and c-Jun N-terminal kinases (JNKs), plays an important role in SUV -induced skin inflammation, and targeting TOPK has already been a strategy to prevent skin inflammation. In this study, we found that the expression of TOPK, phosphorylation of p38 or JNKs was increased in human solar dermatitis tissues...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28382785/autologous-platelet-rich-plasma-versus-readymade-growth-factors-in-skin-rejuvenation-a-split-face-study
#8
Heba I Gawdat, Amira M Tawdy, Rehab A Hegazy, Mohga M Zakaria, Ryham S Allam
BACKGROUND: The escalating urge for a youthful-looking skin instigates continuous innovations with minimally invasive procedures. Readymade growth factors and autologous platelet-rich plasma (PRP) represent such therapeutic interventions. OBJECTIVE: Compare the efficacy and safety of PRP to readymade growth factors in skin rejuvenation. PATIENTS AND METHODS: Twenty adult females with Fitzpatrick skin types III-IV and Glogau photoaging types II and III were enrolled in this study...
April 5, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28373880/effects-of-multipolar-radiofrequency-and-pulsed-electromagnetic-field-treatment-for-face-and-neck-rejuvenation
#9
Thais Cristina Ferraz de Oliveira, Sheyla de Fatima Soares Rocha, Daniel Gontijo Ramos, Camila Gontijo Ramos, Michelle Vanessa Dos Anjos Carvalho, Mariana Gontijo Ramos
Skin aging is a gradual process that leads to wrinkle formation, laxity, and overall changes in skin appearance. In recent years, the demands to noninvasive treatments for facial rejuvenation increased, along with a variety of technologies and devices, such as radiofrequency. The present study aimed to evaluate the clinical effects of a multipolar radiofrequency and pulsed electromagnetic field treatment for face and neck rejuvenation. Eleven patients with mild to moderate grades of photoaging underwent eight radiofrequency and pulsed electromagnetic field treatment sessions, once a week...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28352332/inhibitory-effect-of-salvia-plebeia-leaf-extract-on-ultraviolet-induced-photoaging-associated-ion-channels-and-enzymes
#10
You-Jin Chang, Dong-Ung Lee, Da Yeong Nam, Sung Min Cho, Seungug Hong, Joo Hyun Nam, Woo Kyung Kim
In traditional Korean/Asian medicine, Salvia plebeia R.Br. (S. plebeia) leaves are used to treat inflammatory diseases, including dermatitis, cough, asthma and toothache. Recently, S. plebeia leaves have been applied in skin care, as they promote skin lightening and elasticity. Therefore, the present study investigated the anti-aging effects of S. plebeia leaf methanolic extract and its fractions (dichloromethane, ethylacetate and n-butanol). The results of a whole-cell patch clamp analysis indicated that the methanolic extract mediated ultraviolet (UV)-induced photoaging-associated ion channels, transient receptor potential vanilloid 1 (TRPV1) and calcium release-activated calcium channel protein 1 (ORAI1) channel activity in HEK293T cells overexpressing TRPV1 or ORAI1 and STIM1...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28349655/review-in-peeling-complications
#11
REVIEW
Izelda Maria Carvalho Costa, Patrick Silva Damasceno, Mariana Carvalho Costa, Keila Gabrielle Pati Gomes
Chemical peeling, a procedure wherein a chemical agent is applied to the skin to cause controlled destruction followed by regeneration and remodeling, is a dynamic tool for the treatment of acne, pigmentation issues, and photoaging [Journal of cutaneous and aesthetic surgery vol. 5 (2012) 254-260]. The results and complications are related to the depth of the procedure, with deeper peels producing more marked results and higher rates of complications. Complications are more likely with darker skin types, certain peeling agents, and sun exposure after treatment [Journal of cutaneous and aesthetic surgery vol...
March 27, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28301979/short-time-uva-exposure-to-human-keratinocytes-instigated-polyunsaturated-fatty-acid-without-inducing-lipid-peroxidation
#12
Kin Sum Leung, Hok Fung Chan, Ho Hang Leung, Jean-Marie Galano, Camille Oger, Thierry Durand, Jetty Chung-Yung Lee
Short-term exposure to ultraviolet A (UVA) radiation can directly injure our skin through inflammatory response and indirectly through oxidative stress, triggering polyunsaturated fatty acid (PUFA) peroxidation in skin cell membrane and formation of DNA adduct, 8-hydroxy-2'-deoxyguanosine (8-OHdG). It is known that UVA exposure leads to photoaging, immunosuppression and skin cancer. However, the changes in PUFA and its oxidized metabolites, and cell cycle after short UVA exposure, are debatable. In this study, human keratinocytes (HaCaT) were exposed to low dose (5 J/cm(2)) and high dose (20 J/cm(2)) of UVA and assessed immediately, 8 h, 12 h, and 24 h post-treatment...
March 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28301572/far-infrared-suppresses-skin-photoaging-in-ultraviolet-b-exposed-fibroblasts-and-hairless-mice
#13
Hui-Wen Chiu, Cheng-Hsien Chen, Yi-Jie Chen, Yung-Ho Hsu
Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to block the epidermal hyperproliferative response to UVB and may play a crucial role in preventing skin photoaging. In the present study, we investigated whether far-infrared (FIR) therapy can inhibit skin photoaging via UVB irradiation in NIH 3T3 mouse embryonic fibroblasts and SKH-1 hairless mice...
2017: PloS One
https://www.readbyqxmd.com/read/28293257/the-effectiveness-of-a-5-retinoic-acid-peel-combined-with-microdermabrasion-for-facial-photoaging-a-randomized-double-blind-placebo-controlled-clinical-trial
#14
Gita Faghihi, Saghi Fatemi-Tabaei, Bahareh Abtahi-Naeini, Amir Hossein Siadat, Giti Sadeghian, Mohammad Ali Nilforoushzadeh, Hamed Mohamadian-Shoeili
Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35-70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5% retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28210386/ionic-hydrogel-monotherapy-and-in-combination-with-antiviral-antibiotic-prophylaxis-in-the-post-procedure-management-of-fractional-laser-treated-patients
#15
Francesca Romana Grippaudo
Objective: The pre- and postoperative care for fractionated laser resurfacing is still controversial, especially in regard to the use of antibiotics to prevent bacterial infection and potential consequences. Recently, an ionic hydrogel has shown to be useful in the postoperative treatment of minor burns. The aim of this study is to evaluate the use of this hydrogel after fractional laser treatments targeting photoaging and chronoaging damage to skin. Design: A randomized prospective study. Setting: one plastic surgeon private practice...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28181398/enhanced-high-energy-protocol-using-a-fractional-bipolar-radiofrequency-device-combined-with-bipolar-radiofrequency-and-infrared-light-for-improving-facial-skin-appearance-and-wrinkles
#16
Michael H Gold, Brian S Biesman, Mark Taylor
BACKGROUND: Fractional bipolar radiofrequency treatment and treatment with bipolar radiofrequency combined with infrared light have been shown in previous trials to safely and effectively improve the appearance of facial wrinkles. AIMS: To evaluate a high-energy protocol with combined bipolar radiofrequency and infrared light energies for improvement in photoaged facial skin. PATIENTS/METHODS: Seventy-two patients presenting with mild to moderate facial wrinkles underwent a single full-face treatment (n=54) or two treatments (n=18) at 6-week intervals...
February 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28167957/histological-and-immunohistochemical-evaluation-of-the-efficacy-of-a-new-cosmetic-formulation-in-the-treatment-of-skin-photoaging
#17
M T Truchuelo, N Jiménez, L Miguel-Gomez, A Hermosa, N Sánchez-Neila, J Cuevas
Objective. Mechanism of action of cosmetic products is not often studied. The aim of this study is to determine the histological, immunohistochemical, and clinical changes of a new cosmetic formulation. Methods. Prospective, single-blind, patient-controlled, randomized study in 10 volunteers with mild to moderate skin photoaging on the back of their hands. The product was applied on one hand and a standard cream on the other hand, twice a day for three months. Standardized photographs were taken on basal (T0) and final visit (T1) and skin biopsies were performed...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28095552/a-prospective-split-face-study-of-the-picosecond-alexandrite-laser-with-specialized-lens-array-for-facial-photoaging-in-chinese
#18
Yiping Ge, Lifang Guo, Qiuju Wu, Mengli Zhang, Rong Zeng, Tong Lin
BACKGROUND: A 755nm picosecond alexandrite laser with a diffractive lens array has been reported for the treatment of acne scar and photoaging with clinical ef cacy. In this study, we evaluated the application of the 755nm picosecond alexandrite laser with a diffractive lens array for facial photoaging in Chinese. MATERIALS AND METHODS: Ten subjects with moderate facial photoaging were enrolled in a prospective, evaluator-blinded, open-label, and split-face trial to assess the ef cacy and safety of the 755nm picosecond alexandrite laser with a diffractive lens array for facial photoaging...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095549/treatment-of-facial-photodamage-with-mass-market-topical-products-vs-non-ablative-fractional-laser
#19
RANDOMIZED CONTROLLED TRIAL
Hilary Reich, Irmina Wallander, Lacie Schulte, Molly Goodier, Brian Zelickson
METHODS: In this split-face, evaluator-blinded study, 18 subjects were randomly assigned to receive either the SSR or NFL treatments on each side of the face. For the SSR facial sides subjects followed two morning-evening regimens. On the NFL sides subjects were treated 3 times with the 1927-nm laser at 4-week intervals. Three physician evaluators were asked to rate hyperpigmentation, global photoaging, and ne lines and wrinkles for each side of the face at baseline and at 3 months using a 5-point scale...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28038884/photoprotection-in-specific-populations-children-and-people-of-color
#20
Tania Cestari, Kesha Buster
Improved education on appropriate photoprotection in children is vital. Photoprotection for these individuals should include seeking shade, the use of physical agents (clothing, hat, sunglasses), and application of sunscreens on exposed areas. Avoidance of the use of tanning beds is an important component of education for teenagers. Ultraviolet radiation exposure induces DNA damage and photoaging in all skin types, including people of color. The extent of such damage is inversely related to constitutive skin pigmentation...
March 2017: Journal of the American Academy of Dermatology
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