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Photoaging treatment

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https://www.readbyqxmd.com/read/28095552/a-prospective-split-face-study-of-the-picosecond-alexandrite-laser-with-specialized-lens-array-for-facial-photoaging-in-chinese
#1
Yiping Ge, Lifang Guo, Qiuju Wu, Mengli Zhang, Rong Zeng, Tong Lin
BACKGROUND: A 755nm picosecond alexandrite laser with a diffractive lens array has been reported for the treatment of acne scar and photoaging with clinical ef cacy. In this study, we evaluated the application of the 755nm picosecond alexandrite laser with a diffractive lens array for facial photoaging in Chinese. MATERIALS AND METHODS: Ten subjects with moderate facial photoaging were enrolled in a prospective, evaluator-blinded, open-label, and split-face trial to assess the ef cacy and safety of the 755nm picosecond alexandrite laser with a diffractive lens array for facial photoaging...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095549/treatment-of-facial-photodamage-with-mass-market-topical-products-vs-non-ablative-fractional-laser
#2
Hilary Reich, Irmina Wallander, Lacie Schulte, Molly Goodier, Brian Zelickson
METHODS: In this split-face, evaluator-blinded study, 18 subjects were randomly assigned to receive either the SSR or NFL treatments on each side of the face. For the SSR facial sides subjects followed two morning-evening regimens. On the NFL sides subjects were treated 3 times with the 1927-nm laser at 4-week intervals. Three physician evaluators were asked to rate hyperpigmentation, global photoaging, and ne lines and wrinkles for each side of the face at baseline and at 3 months using a 5-point scale...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28038884/photoprotection-in-specific-populations-children-and-people-of-color
#3
Tania Cestari, Kesha Buster
Improved education on appropriate photoprotection in children is vital. Photoprotection for these individuals should include seeking shade, the use of physical agents (clothing, hat, sunglasses), and application of sunscreens on exposed areas. Avoidance of the use of tanning beds is an important component of education for teenagers. Ultraviolet radiation exposure induces DNA damage and photoaging in all skin types, including people of color. The extent of such damage is inversely related to constitutive skin pigmentation...
December 23, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28011874/activation-of-nrf2-reduces-uva-mediated-mmp-1-upregulation-via-mapk-ap-1-signaling-cascades-the-photoprotective-effects-of-sulforaphane-and-hispidulin
#4
Anyamanee Chaiprasongsuk, Jinaphat Lohakul, Kitipong Soontrapa, Somponnat Sampattavanich, Pravit Akarasereenont, Uraiwan Panich
Ultraviolet A (UVA) irradiation plays a role in premature aging of the skin through triggering oxidative stress-associated stimulation of matrix metalloproteinase-1 (MMP-1) responsible for collagen degradation, a hallmark of photoaged skin. Compounds which can activate Nrf2, a transcription factor regulating antioxidant gene expression, should therefore serve as effective anti-photoaging agents. We investigated whether genetic silencing of Nrf2 could relieve UVA-mediated MMP-1 upregulation via activation of MAPK/AP-1 signaling using human keratinocyte cell line (HaCaT)...
December 23, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27959406/ganoderma-lucidum-polysaccharides-protect-fibroblasts-against-uvb-induced-photoaging
#5
Qinghai Zeng, Fang Zhou, Li Lei, Jing Chen, Jianyun Lu, Jianda Zhou, Ke Cao, Lihua Gao, Fang Xia, Shu Ding, Lihua Huang, Hong Xiang, Jingjing Wang, Yangfan Xiao, Rong Xiao, Jinhua Huang
Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. Ganoderma polysaccharides (GL-PS), a major active ingredient in Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects. The aim of the present study was to investigate the efficacy and mechanism of GL‑PS‑associated inhibition of ultraviolet B (UVB)‑induced photoaging in human fibroblasts in vitro. Primary human skin fibroblasts were cultured, and a fibroblast photoaging model was built through exposure to UVB...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27935061/autophagy-in-uv-damage-response
#6
Ashley Sample, Yu-Ying He
UV radiation exposure from sunlight and artificial tanning beds is the major risk factor for the development of skin cancer and skin photoaging. UV-induced skin damage can trigger a cascade of DNA damage response signaling pathways, including cell cycle arrest, DNA repair, and, if damage is irreparable, apoptosis. Compensatory proliferation replaces the apoptotic cells to maintain skin barrier integrity. Disruption of these processes can be exploited to promote carcinogenesis by allowing the survival and proliferation of damaged cells...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27932255/triolein-reduces-mmp-1-upregulation-in-dermal-fibroblasts-generated-by-ros-production-in-uvb-irradiated-keratinocytes
#7
Gustavo J Leirós, Ana Gabriela Kusinsky, María Eugenia Balañá, Karin Hagelin
BACKGROUND: Cytokine production and oxidative stress generated by ultraviolet radiation B (UVB) skin exposure are main factors of skin photoaging. Interleukin-6 (IL-6) produced by irradiated keratinocytes is proposed to have a role in metalloproteinases (MMPs) expression activation in dermal fibroblasts. OBJECTIVES: We examined the effect of triolein treatment of UVB-irradiated keratinocytes on MMP1 (interstitial collagenase) expression response of dermal fibroblasts...
February 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27880964/protective-effects-of-standardized-siegesbeckia-glabrescens-extract-and-its-active-compound-kirenol-against-uvb-induced-photoaging-through-inhibition-of-mapk-nf-%C3%AE%C2%BAb-pathways
#8
Jongwook Kim, Mi-Bo Kim, Jun Gon Yun, Jae Kwan Hwang
Anti-photoaging effects of standardized Siegesbeckia glabrescens extract (SGE) and its major active compound kirenol were investigated using Hs68 human dermal fibroblasts and hairless mice, respectively. UVB-irradiated hairless mice that received oral SGE (600 mg/kg/day) showed reduced wrinkle formation and skinfold thickness compared to the UVB-irradiated control. Furthermore, SGE treatment increased the mRNA levels of collagen synthesis genes (COL1A1, COL3A1, COL4A1, and COL7A1) and activated antioxidant enzyme (catalase), while suppressing the matrix metalloproteinases (MMPs; MMP-2, -3, -9, and -13) expression...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27847821/djulis-chenopodium-formosanum-koidz-water-extract-and-its-bioactive-components-ameliorate-dermal-damage-in-uvb-irradiated-skin-models
#9
Yong-Han Hong, Ya-Ling Huang, Yao-Cheng Liu, Pi-Jen Tsai
Dermal photoaging is a condition of skin suffering inappropriate ultraviolet (UV) exposure and exerts inflammation, tissue alterations, redness, swelling, and uncomfortable feelings. Djulis (Chenopodium formosanum Koidz.) is a cereal food and its antioxidant and pigment constituents may provide skin protection from photoaging, but it still lacks proved experiments. In this study, protective effects of djulis extract (CFE) on UVB-irradiated skin were explored. The results showed that HaCaT cells with 150 μg/mL CFE treatment had higher survival and less production of interleukin- (IL-) 6, matrix metalloprotease- (MMP-) 1, and reactive oxygen species (ROS) in UVB-irradiated conditions...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27816646/hesperidin-ameliorates-uv-radiation-induced-skin-damage-by-abrogation-of-oxidative-stress-and-inflammatory-in-hacat-cells
#10
Min Li, Xiang-Fei Lin, Jie Lu, Bing-Rong Zhou, Dan Luo
Ultraviolet A (UVA) radiation contributes to skin photoaging. Hesperidin which is a flavanone glycoside found in citrus fruit peels, have been intensively studied for their UVA-protective activity, but its effects and mechanisms on UVA irradiation-induced inflammation and oxidative stress have never been described. Thus, the purpose of this study was to evaluate the effects of hesperidin in skin oxidative stress and inflammation induced by UVA irradiation. In this study, we firstly examined whether hesperidin may exert direct protective effects on the UVA-induced in human keratinocytes (HaCaT) cell injury in vitro...
December 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27794421/a-topical-mitochondria-targeted-redox-cycling-nitroxide-mitigates-oxidative-stress-induced-skin-damage
#11
Rhonda M Brand, Michael W Epperly, J Mark Stottlemyer, Erin M Skoda, Xiang Gao, Song Li, Saiful Huq, Peter Wipf, Valerian E Kagan, Joel S Greenberger, Louis D Falo
Skin is the largest human organ, and it provides a first line of defense that includes physical, chemical, and immune mechanisms to combat environmental stress. Radiation is a prevalent environmental stressor. Radiation-induced skin damage ranges from photoaging and cutaneous carcinogenesis caused by UV exposure, to treatment-limiting radiation dermatitis associated with radiotherapy, to cutaneous radiation syndrome, a frequently fatal consequence of exposures from nuclear accidents. The major mechanism of skin injury common to these exposures is radiation-induced oxidative stress...
October 26, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27781390/a-multicenter-placebo-controlled-double-blind-clinical-trial-assessing-the-effects-of-a-multicomponent-nutritional-supplement-for-treating-photoaged-skin-in-healthy-women
#12
Jay E Birnbaum, David H McDaniel, Janet Hickman, Lisa Dispensa, Anne Le Moigne, Larry Buchner
BACKGROUND: Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance. AIMS: Evaluate a multicomponent nutritional supplement on photoaged skin. PATIENTS/METHODS: This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatrick skin types I-IV and Glogau classification types II-III to a multicomponent nutritional supplement or placebo for 24 weeks...
October 25, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27765346/dietary-foeniculum-vulgare-mill-extract-attenuated-uvb-irradiation-induced-skin-photoaging-by-activating-of-nrf2-and-inhibiting-mapk-pathways
#13
Zhengwang Sun, Sang Yong Park, Eunson Hwang, Bom Park, Seul A Seo, Jin-Gyeong Cho, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Foeniculum vulgare Mill (FV) has long been prescribed in traditional medicine due to its antioxidant anti-inflammatory properties. However, little research has been done on the use of FV to alleviate changes in UVB-induced photoaging PURPOSE: This study was to investigate the photoprotective effects and mechanism of FV in vitro and in vivo. METHODS: The anti-photoaging effect of FV was assessed in normal human dermal fibroblasts (NHDFs) in vitro. The secretion of reactive oxygen species (ROS), lactate dehydrogenase (LDH), GSH, matrix metalloproteinases (MMPs), procollagen type I, IL-6 and transforming growth factor-β1 (TGF-β1) were measured by kits...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27681221/safety-and-efficacy-of-a-novel-diffractive-lens-array-using-a-picosecond-755%C3%A2-nm-alexandrite-laser-for-treatment-of-wrinkles
#14
Robert A Weiss, David H McDaniel, Margaret A Weiss, Anne Marie Mahoney, Karen L Beasley, Christian R Halvorson
INTRODUCTION: Picosecond lasers have been reported to be effective for removal of tattoo pigment. This prospective study evaluated the efficacy and safety of the treatment of peri-oral and -ocular wrinkles using a novel diffractive lens array coupled with a picosecond 755 nm alexandrite laser. METHODS: Forty female subjects presenting with wrinkles from photodamage were enrolled in an IRB approved study. Subjects received four picosecond diffractive lens array treatments to the full face at 1 month intervals...
September 29, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27641753/thymus-vulgaris-alleviates-uvb-irradiation-induced-skin-damage-via-inhibition-of-mapk-ap-1-and-activation-of-nrf2-are-antioxidant-system
#15
Zhengwang Sun, Sang Yong Park, Eunson Hwang, Mengyang Zhang, Seul A Seo, Pei Lin, Tae-Hoo Yi
Solar ultraviolet (UV) radiation-induced reactive oxidative species is mainly responsible for the development of photoageing. Rosmarinic acid was one of the main bioactive components detected in Thymus vulgaris (TV) we extracted. In this study, UVB-induced skin damages have been shown to be ameliorated by treatment with TV in hairless mice (HR-1) skin, demonstrated by decreased matrix metalloproteinases (MMPs) and increased collagen production. However, the underlying molecular mechanism on which TV acted was unclear...
September 19, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27640402/objective-severity-does-not-capture-the-impact-of-rosacea-acne-scarring-and-photoaging-in-patients-seeking-laser-therapy
#16
C L Thomas, B Kim, J Lam, S Richards, A See, S Kalouche, R D Paver, P Fernández Peñas
BACKGROUND: Measures of quality of life (QOL) and patient satisfaction are of great importance in dermatology, as both impact upon treatment adherence and health outcomes. Patients' assessment of QOL often differs from their doctors' predictions and their assessments of skin disease severity do not correlate with patients' own perceptions. The development of laser technology has facilitated successful treatment of many skin conditions, but studies on patient satisfaction are lacking. OBJECTIVES: Our aim was to determine the extent of discordance between patient and dermatologist-assessed disease severity and assess the impact of acne scarring, rosacea and photoaging on QOL...
September 18, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27638433/the-dark-side-of-the-light-phototherapy-adverse-effects
#17
Margarida Moura Valejo Coelho, Margarida Apetato
Phototherapy is a valuable therapeutic tool in Dermatology, but there may be drawbacks. Acute and long-term adverse effects, of variable severity, include skin erythema, xerosis, pruritus, blistering, altered pigmentation, photoaging, and photocarcinogenesis. Despite concerns over the carcinogenic potential of ultraviolet radiation, most studies have not found an increased risk of non-melanoma or melanoma skin cancer in patients treated with ultraviolet B (broadband and narrowband) and ultraviolet A1 phototherapy...
September 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27609754/protective-effect-of-cornus-walteri-wangerin-leaf-against-uvb-irradiation-induced-photoaging-in-human-reconstituted-skin
#18
Hyun-Chul Park, Taek Kyu Jung, Mi Jin Kim, Kyung-Sup Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus walteri Wangerin has been used in oriental traditional medicine for the treatment of antidiarrheal and inflammation. AIM OF THE STUDY: The efficacy of Cornus walteri Wangerin on skin anti-photoaging was investigated. MATERIALS AND METHODS: Hydrolyzed Cornus walteri Wangerin leaf was tested for the anti-photoaging effects against ultraviolet B (UVB)-induced matrix metalloproteinase (MMP)-1, pro-inflammatory cytokines using human reconstituted skin (KeraSkin™-FT) and also tested for elastase activity in vitro...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27602981/the-effects-of-a-daily-skincare-regimen-on-maintaining-the-benefits-obtained-from-previous-chemical-resurfacing-treatments
#19
Suzanne Bruce, Wendy Roberts, Craig Teller, Lora Colvan
BACKGROUND: Chemical peels are versatile treatments that involve chemical exfoliation of the skin for cosmetic improvement. Deeper peels produce more significant results, but can be associated with longer healing time and potential complications. Novel chemical resurfacing treatments (AGE and MELA) were developed in Europe to produce skin resurfacing via controlled inflammation to promote cell regeneration with minimum negative effects associated with conventional peelings. The AGE Resurfacing regimen is indicated for the treatment of photoaging, and consists of multi-ingredient peeling solution with trichloroacetic acid, pyruvic acid, salicylic acid, mandelic acid, and lactobionic acid...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27598132/novel-anti-melanogenesis-properties-of-polydeoxyribonucleotide-a-popular-wound-healing-booster
#20
Tai Kyung Noh, Bo Young Chung, Su Yeon Kim, Mi Hye Lee, Moon Jung Kim, Choon Shik Youn, Mi Woo Lee, Sung Eun Chang
Polydeoxyribonucleotide (PDRN), a deoxyribonucleotide polymer, is popularly used for faster healing of cutaneous wounds and boosting of neocollagenesis of photoaged skin among current dermatologic practitioners. Some patients receiving PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP). To investigate the effect of PDRN on cutaneous melanogenesis, we examined the effect of PDRN and an available product (Placentex(®)) containing PDRN on melanogenesis using human melanocytes-keratinocytes cocultures and mouse melanocytes...
September 1, 2016: International Journal of Molecular Sciences
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