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Photoaging treatment

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https://www.readbyqxmd.com/read/29779217/ginsenoside-c-mx-isolated-from-notoginseng-stem-leaf-ginsenosides-attenuates-ultraviolet-b-mediated-photoaging-in-human-dermal-fibroblasts
#1
Xiao-Yi Liu, Eunson Hwang, Bom Park, Hien T T Ngo, Yong-Kun Xiao, Tae-Hoo Yi
Notoginseng is a traditional herbal medicine widely used for medicinal therapy in Asia, as it contains numerous ginsenosides with pharmacological effects. In this study, we submitted Notoginseng stem-leaf (NGL) ginsenosides to an enzyme to create reaction the monomer products of ginsenoside C-Mx and then investigated the ability of ginsenoside C-Mx to protect the skin against ultraviolet B-induced injury in normal human dermal fibroblasts (NHDFs). Ginsenoside C-Mx alleviated UVB-induced intracellular reactive oxygen species (ROS), MMP-1, and IL-6 expression while accelerating TGF-β and procollagen type I secretion...
May 20, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29768726/ribes-nigrum-l-prevents-uvb-mediated-photoaging-in-human-dermal-fibroblasts-potential-antioxidant-and-anti-inflammatory-activity
#2
Lu Li, Eunson Hwang, Hien T T Ngo, Seul A Seo, Pei Lin, Wei Gao, Ying Liu, Tae-Hoo Yi
Black currants (Ribes nigrum L, RN) are known as a "super fruit" to possess for their many potential health benefits such as the alleviation of oxidative stress-related disorders. However, little skin photoaging-related research has been done on the use of this agent. In the present study, we investigated the protective effects of RN in UVB-irradiated human dermal fibroblasts (NHDFs). RN treatment in UVB-irradiated skin models alleviated UVB-mediated photoaging through several mechanisms: Treatment with RN downregulated MAPK-related signaling models, such as those of activation protein 1 (AP-1) and nuclear factor kappa B (NF-κB)...
May 16, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29704456/tretinoin-0-05-cream-versus-5-peel-for-photoaging-and-field-cancerization-of-the-forearms-randomized-evaluator-blinded-clinical-trial
#3
J M Sumita, H A Miot, J L M Soares, A C P Raminelli, S M Pereira, M M Ogawa, F R Picosse, L R S Guadanhim, M M S S Enokihara, G R Leonardi, E Bagatin
BACKGROUND: Topical tretinoin cream is the gold standard treatment for skin aging, particularly photoaging. The purpose of tretinoin peel is to obtain similar results but in a shorter time, however there have been few controlled trials on its effectiveness. OBJECTIVE: To compare efficacy and safety of tretinoin 0.05% cream and 5% as a peeling agent on photoaging and field cancerization of the forearms. METHODS: Clinical trial with therapeutic intervention, prospective, randomized (computer-generated randomization list), parallel, comparative (intrasubject) and evaluator-blinded (except for histology and immunohistochemistry), including twenty-four women (48 forearms) aged over 60 years who have not undergone hormone replacement, and categorized as Fitzpatrick skin phototype II or III...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29689326/analysis-of-spin-in-the-reporting-of-studies-of-topical-treatments-of-photoaged-skin
#4
Catherine C Motosko, Anna K Ault, Laura L Kimberly, M David Gothard, Roger S Ho, Alexes Hazen
BACKGROUND: Spin-reporting that distorts the interpretation of results-is not unusual within scientific literature. OBJECTIVE: To appraise strategies of spin among placebo-controlled double-blind clinical trials of topical treatments for photoaged skin. METHODS: A systematic review of literature was performed to identify placebo-controlled double-blind clinical trials of topical treatments for photoaged skin. A survey of spin strategies was developed and applied to the cohort of identified studies...
April 21, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29664771/effects-of-1-540-nm-fractional-nonablative-erbium-and-2-940-nm-fractional-ablative-erbium-on-p53-epidermal-expression-after-3-months-a-split-face-interventional-study
#5
Juliano Borges, Luciana Araújo, Rodrigo P B de Oliveira, Monica Manela-Azulay
BACKGROUND: Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light. OBJECTIVE: We used side-by-side nonablative and ablative erbium fractional laser resurfacing to assess the effects on expression of p53 by facial keratinocytes. METHODS: Ten female patients (age range, 50-63 years) with Fitzpatrick skin Types I-IV and clinical signs of photoaging underwent erbium fractional laser resurfacing (nonablative, 1,540-nm; ablative, 2,940-nm) on opposite sides of the face...
April 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29619069/-piper-retrofractum-vahl-extract-as-a-ppar-%C3%AE-and-ampk-activator-suppresses-uvb-induced-photoaging-through-mitochondrial-biogenesis-and-mmps-inhibition-in-human-dermal-fibroblasts-and-hairless-mice
#6
Jungon Yun, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang
Photoaging occurs by UVB-irradiation and involves production of reactive oxygen species (ROS) and overexpression of matrix metalloproteinases (MMPs), leading to extracellular matrix damage. Piper retrofractum Vahl. is used as a traditional medicine for antiflatulence, expectorant, sedative, and anti-irritant; however, its antiphotoaging effect has not yet been studied. The current study investigated the antiphotoaging effect of standardized Piper retrofractum extract (PRE) on UVB-damaged human dermal fibroblasts and hairless mouse skin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29576056/brazilin-and-caesalpinia-sappan-l-extract-protect-epidermal-keratinocytes-from-oxidative-stress-by-inducing-the-expression-of-gpx7
#7
Hyung Seo Hwang, Joong Hyun Shim
Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in Southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk medicines in the treatment of diarrhea, dysentery, tuberculosis, skin infections, and inflammation. Brazilin is the major active compound, which has exhibited various pharmacological effects, including anti-platelet activity, anti-hepatotoxicity, induction of immunological tolerance, and anti-inflammatory and antioxidant activities...
March 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29532689/protective-effect-of-neferine-against-uv-b-mediated-oxidative-damage-in-human-epidermal-keratinocytes
#8
Abidullah Khan, Bai Hongliang, Enqi Liu, Chen Mingxia, Yu Chunshui, Rai Wang, Khan Amin, Bai Zhuanli
Studies have shown that skin exposure to ultraviolet radiation (UVR) results in the formation of reactive oxygen species (ROS), thus altering the cellular function. The human epidermal skin layer is mainly composed of keratinocytes, which is damaged by UV-B radiation induced intracellular oxidative stress. Neferine is an alkaloid extract from lotus seed embryos, and its photoprotective action against UV-B produced oxidative damage in human epidermal keratinocytes (HEKs) has never been proposed. Neferine inhibited UV-B mediated increase in ROS and malondialdehyde (MDA) levels in pretreated keratinocytes...
March 13, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29525471/exposure-of-human-melanocytes-to-uvb-twice-and-subsequent-incubation-leads-to-cellular-senescence-and-senescence-associated-pigmentation-through-the-prolonged-p53-expression
#9
Suh-Yeon Choi, Bum-Ho Bin, Wanil Kim, Eunkyung Lee, Tae Ryong Lee, Eun-Gyung Cho
BACKGROUND: Ultraviolet radiation (UVR) is a well-known factor in skin aging and pigmentation, and daily exposure to subcytotoxic doses of UVR might accelerate senescence and senescence-associated phenomena in human melanocytes. OBJECTIVE: To establish an in vitro melanocyte model to mimic the conditions of repeated exposure to subcytotoxic doses of UVB irradiation and to investigate key factor(s) for melanocyte senescence and senescence-associated phenomena. METHODS: Human epidermal melanocytes were exposed twice with 20 mJ/cm2 UVB over a 24-h interval and subsequently cultivated for 2 weeks...
June 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29521149/protective-properties-of-geniposide-against-uv-b-induced-photooxidative-stress-in-human-dermal-fibroblasts
#10
Daehyun Shin, Sihyeong Lee, Yu-Hua Huang, Hye-Won Lim, Yoonjin Lee, Kyounghee Jang, Yongwan Cho, Sang Jun Park, Dae-Duk Kim, Chang-Jin Lim
CONTEXT: Geniposide (genipin-1-O-β-d-glucoside) is a major bioactive ingredient in the fruits of gardenia [Gardenia jasminoides J. Ellis (Rubiaceae)], a traditional herbal medicine in Asian countries. OBJECTIVE: This work assesses the skin anti-photoaging potential of geniposide in human dermal fibroblasts under UV-B irradiation. MATERIALS AND METHODS: The anti-photoaging property of geniposide, at varying concentrations (5, 12 and 30 μM) treated for 30 min prior to UV-B irradiation, was evaluated by analysing reactive oxygen species (ROS), promatrix metalloproteinase-2 (proMMP-2), glutathione (GSH), superoxide dismutase (SOD), nuclear factor erythroid 2-related factor 2 (Nrf2) and cellular viability...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29518457/assessing-the-safety-of-superficial-chemical-peels-in-darker-skin-a-retrospective-study
#11
Shalini Vemula, Mayra B C Maymone, Eric A Secemsky, Raphael Widjajahakim, Nicole M Patzelt, Dana Saade, Neelam A Vashi
BACKGROUND: Chemical peels have shown efficacy in the treatment of acne, photoaging, and pigmentary dyschromias; however, studies evaluating side effects, particularly in patients with skin of color, are limited. OBJECTIVE: We sought to determine the frequency of side effects and complications associated with superficial chemical peels in patients with skin types III-VI. METHODS: A 5-year single center retrospective analysis was performed...
March 5, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29504972/ablative-fractional-carbon-dioxide-laser-combined-with-intense-pulsed-light-for-the-treatment-of-photoaging-skin-in-chinese-population-a-split-face-study
#12
Xue-Ling Mei, Li Wang
Intense pulsed light (IPL) is effective for the treatment of lentigines, telangiectasia, and generalized erythema, but is less effective in the removal of skin wrinkles. Fractional laser is effective on skin wrinkles and textural irregularities, but can induce postinflammatory hyperpigmentation (PIH), especially in Asians. This study evaluated the safety and efficacy of ablative fractional laser (AFL) in combination with IPL in the treatment of photoaging skin in Asians.This study included 28 Chinese women with Fitzpatrick skin type III and IV...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29499374/borago-officinalis-l-attenuates-uvb-induced-skin-photodamage-via-regulation-of-ap-1-and-nrf2-are-pathway-in-normal-human-dermal-fibroblasts-and-promotion-of-collagen-synthesis-in-hairless-mice
#13
Seul A Seo, Bom Park, Eunson Hwang, Sang-Yong Park, Tae-Hoo Yi
Ultraviolet B (UVB) irradiation is regarded as the main cause of skin photodamage. After exposure to UVB irradiation, collagen degradation is accelerated by upregulation of matrix metalloproteinases (MMPs), and collagen synthesis is decreased via downregulation of transforming growth factor (TGF)-β1 signaling. Borago officinalis L. (BO) is an annual herb with medicinal and culinary applications. Although BO has been demonstrated to have antioxidant and anti-inflammatory activities, its potential anti-photoaging effects have not been examined...
July 1, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29484380/black-rice-oryza-sativa-l-extract-modulates-ultraviolet-induced-expression-of-matrix-metalloproteinases-and-procollagen-in-a-skin-cell-model
#14
Mira Han, Jung-Soo Bae, Jae-Jun Ban, Hee Soon Shin, Dong Hun Lee, Jin Ho Chung
Exposure of the skin to ultraviolet (UV) radiation causes extracellular matrix (ECM) collapse in the dermis, owing to an increase in matrix metalloproteinase (MMP) production in both the epidermis and dermis, and a decrease in type I collagen expression in the dermis. Recently, black rice (Oryza sativa L.) was reported to have a wide range of pharmacological effects in various settings. However, the effects of black rice extract (BRE) on UV‑irradiated skin cells have not yet been characterized. BRE treatment did not affect cell morphology and viability of HaCaT and human dermal fibroblasts (HDF)...
May 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29482397/a-prospective-randomized-double-blinded-split-face-pilot-study-comparing-q-switched-1064-nm-nd-yag-versus-532-nm-nd-yag-laser-for-the-treatment-of-solar-lentigines
#15
Krista Bohnert, Andrew Dorizas, Neil Sadick
Treating photoaging with laser technologies has increased in popularity due to their efficacy, minimal downtime, and side effects. New Q-Switched (QS) Nd:YAG lasers' frequency doubled with 532 nm wavelength can both target epidermal chromophores as well as stimulate collagen production. The objective of this study was to compare single-pulsed 1064-nm Nd:YAG with dual-pulsed 532-nm/1064-nm QS laser for reducing solar lentigines. Ten subjects with solar lentigines were enrolled in this prospective, randomized, double-blind, split-face study...
February 26, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29457847/preconditioning-with-low-level-laser-irradiation-enhances-the-therapeutic-potential-of-human-adipose-derived-stem-cells-in-a-mouse-model-of-photoaged-skin
#16
Xuan Liao, Sheng-Hong Li, Guang-Hui Xie, Shan Xie, Li-Ling Xiao, Jian-Xing Song, Hong-Wei Liu
This study was conducted to explore the therapeutic potential of human adipose-derived stem cells (ADSCs) irradiated with a low-level laser (LLL). Cultured ADSCs were treated with 650-nm GaAlAs laser irradiation at 2, 4 and 8 J cm-2 . Cell proliferation was quantified by MTT assays, cytokine secretion was determined by enzyme-linked immunosorbent assays, and adipogenic differentiation was examined by oil red O staining. Additionally, the expression profiles of putative ADSC surface markers were analyzed by quantitative real-time PCR...
February 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29431281/remodeling-of-dermal-collagen-in-photoaged-skin-using-low-dose-5-aminolevulinic-acid-photodynamic-therapy-occurs-via-the-transforming-growth-factor-%C3%AE-pathway
#17
Peiru Wang, Jiatong Han, Minglei Wei, Yuting Xu, Guolong Zhang, Haiyan Zhang, Lei Shi, Xiaojing Liu, Michael R Hamblin, Xiuli Wang
5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is known to be effective in the treatment of photoaged skin. However, the molecular mechanisms still remain elusive. Protoporphyrin IX (PpIX) fluorescence is primarily located in the epidermis while ALA-PDT affects the dermal collagen, presumably by an indirect mechanism. This study aimed to investigate the molecular communication in low-dose ALA-PDT occurring between epidermal keratinocytes and dermal fibroblasts. Western blotting and enzyme-linked immunosorbent assays were performed to evaluate collagen expression and transforming growth factor-β (TGF-β) signaling in human keratinocytes and dermal fibroblasts...
February 12, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29399294/topical-or-oral-treatment-of-peach-flower-extract-attenuates-uv-induced-epidermal-thickening-matrix-metalloproteinase-13-expression-and-pro-inflammatory-cytokine-production-in-hairless-mice-skin
#18
Chung Shil Kwak, Jiwon Yang, Chang-Yup Shin, Jin Ho Chung
BACKGROUND/OBJECTIVES: Ultraviolet radiation (UV) is a major cause of skin photoaging. Previous studies reported that ethanol extract (PET) of Prunus persica (L.) Batsch flowers (PPF, peach flowers) and its subfractions, particularly the ethylacetate (PEA) and n-butanol extracts (PBT), have potent antioxidant activity and attenuate the UV-induced matrix metalloproteinase (MMP) expression in human skin cells. In this study, we investigated the protective activity of PPF extract against UV-induced photoaging in a mouse model...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29395579/trans-cinnamic-acid-attenuates-uva-induced-photoaging-through-inhibition-of-ap-1-activation-and-induction-of-nrf2-mediated-antioxidant-genes-in-human-skin-fibroblasts
#19
You-Cheng Hseu, Mallikarjuna Korivi, Fang-Ying Lin, Mei-Ling Li, Ruei-Wan Lin, Jia-Jiuan Wu, Hsin-Ling Yang
BACKGROUND: UVA irradiation-induced skin damage/photoaging is associated with redox imbalance and collagen degradation. OBJECTIVE: Dermato-protective efficacies of trans-cinnamic acid (t-CA), a naturally occurring aromatic compound have been investigated against UVA irradiation, and elucidated underlying molecular mechanism. METHODS: Human foreskin fibroblast-derived (Hs68) cells and nude mice were treated with t-CA prior to UVA exposure, and assayed the anti-photoaging effects of t-CA...
January 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29394139/longitudinal-evaluation-of-radiopacity-of-resin-composites-influence-of-photoactivation-and-accelerated-photoaging
#20
A D Cruz, Iam Costa, F S Calazans, M F Aguiar, M O Barceleiro
This study aimed to assess longitudinally the radiopacity of resin composites under the influence of photoactivation and photoaging processes. Ten specimens (1 mm thick and 4 mm in diameter) of three different microhybrid resin composites, Filtek Z250 XT (R1), TPH 3 Spectrum (R2), and Opallis (R3), were prepared for this study. For longitudinal assessment of radiopacity, radiographic images were obtained five times. The first time (T1), the specimens were not photoactivated; the second time (T2), the specimens were photoactivated; and the next three times, photoaging was carried out, with images obtained at 24 hours (T3), 48 hours (T4), and 72 hours (T5) after this process...
March 2018: Operative Dentistry
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