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https://www.readbyqxmd.com/read/27880964/protective-effects-of-standardized-siegesbeckia-glabrescens-extract-and-its-active-compound-kirenol-against-uvb-induced-photoaging-through-inhibition-of-mapk-nf-%C3%AE%C2%BAb-pathways
#1
Jongwook Kim, Mi-Bo Kim, Jun Gon Yun, Jae Kwan Hwang
Anti-photoaging effects of standardized Siegesbeckia glabrescens extract (SGE) and its major active compound kirenol were investigated using Hs68 human dermal fibroblasts and hairless mice, respectively. UVB-irradiated hairless mice that received oral SGE (600 mg/kg/day) showed reduced wrinkle formation and skinfold thickness compared to the UVB-irradiated control. Furthermore, SGE treatment increased the mRNA levels of collagen synthesis genes (COL1A1, COL3A1, COL4A1, and COL7A1) and activated antioxidant enzyme (catalase), while suppressing the matrix metalloproteinases (MMPs; MMP-2, -3, -9, and -13) expression...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27847821/djulis-chenopodium-formosanum-koidz-water-extract-and-its-bioactive-components-ameliorate-dermal-damage-in-uvb-irradiated-skin-models
#2
Yong-Han Hong, Ya-Ling Huang, Yao-Cheng Liu, Pi-Jen Tsai
Dermal photoaging is a condition of skin suffering inappropriate ultraviolet (UV) exposure and exerts inflammation, tissue alterations, redness, swelling, and uncomfortable feelings. Djulis (Chenopodium formosanum Koidz.) is a cereal food and its antioxidant and pigment constituents may provide skin protection from photoaging, but it still lacks proved experiments. In this study, protective effects of djulis extract (CFE) on UVB-irradiated skin were explored. The results showed that HaCaT cells with 150 μg/mL CFE treatment had higher survival and less production of interleukin- (IL-) 6, matrix metalloprotease- (MMP-) 1, and reactive oxygen species (ROS) in UVB-irradiated conditions...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27816646/hesperidin-ameliorates-uv-radiation-induced-skin-damage-by-abrogation-of-oxidative-stress-and-inflammatory-in-hacat-cells
#3
Min Li, Xiang-Fei Lin, Jie Lu, Bing-Rong Zhou, Dan Luo
Ultraviolet A (UVA) radiation contributes to skin photoaging. Hesperidin which is a flavanone glycoside found in citrus fruit peels, have been intensively studied for their UVA-protective activity, but its effects and mechanisms on UVA irradiation-induced inflammation and oxidative stress have never been described. Thus, the purpose of this study was to evaluate the effects of hesperidin in skin oxidative stress and inflammation induced by UVA irradiation. In this study, we firstly examined whether hesperidin may exert direct protective effects on the UVA-induced in human keratinocytes (HaCaT) cell injury in vitro...
November 1, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27794421/a-topical-mitochondria-targeted-redox-cycling-nitroxide-mitigates-oxidative-stress-induced-skin-damage
#4
Rhonda M Brand, Michael W Epperly, J Mark Stottlemyer, Erin M Skoda, Xiang Gao, Song Li, Saiful Huq, Peter Wipf, Valerian E Kagan, Joel S Greenberger, Louis D Falo
Skin is the largest human organ and provides a first line of defense that includes physical, chemical, and immune mechanisms to combat environmental stress. Radiation is a prevalent environmental stressor. Radiation induced skin damage ranges from photoaging and cutaneous carcinogenesis from UV exposure, to treatment-limiting radiation dermatitis associated with radiotherapy, to cutaneous radiation syndrome, a frequently fatal consequence of exposures from nuclear accidents. The major mechanism of skin injury common to these exposures is radiation induced oxidative stress...
October 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27781390/a-multicenter-placebo-controlled-double-blind-clinical-trial-assessing-the-effects-of-a-multicomponent-nutritional-supplement-for-treating-photoaged-skin-in-healthy-women
#5
Jay E Birnbaum, David H McDaniel, Janet Hickman, Lisa Dispensa, Anne Le Moigne, Larry Buchner
BACKGROUND: Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance. AIMS: Evaluate a multicomponent nutritional supplement on photoaged skin. PATIENTS/METHODS: This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatrick skin types I-IV and Glogau classification types II-III to a multicomponent nutritional supplement or placebo for 24 weeks...
October 25, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27765346/dietary-foeniculum-vulgare-mill-extract-attenuated-uvb-irradiation-induced-skin-photoaging-by-activating-of-nrf2-and-inhibiting-mapk-pathways
#6
Zhengwang Sun, Sang Yong Park, Eunson Hwang, Bom Park, Seul A Seo, Jin-Gyeong Cho, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Foeniculum vulgare Mill (FV) has long been prescribed in traditional medicine due to its antioxidant anti-inflammatory properties. However, little research has been done on the use of FV to alleviate changes in UVB-induced photoaging PURPOSE: This study was to investigate the photoprotective effects and mechanism of FV in vitro and in vivo. METHODS: The anti-photoaging effect of FV was assessed in normal human dermal fibroblasts (NHDFs) in vitro. The secretion of reactive oxygen species (ROS), lactate dehydrogenase (LDH), GSH, matrix metalloproteinases (MMPs), procollagen type I, IL-6 and transforming growth factor-β1 (TGF-β1) were measured by kits...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27681221/safety-and-efficacy-of-a-novel-diffractive-lens-array-using-a-picosecond-755%C3%A2-nm-alexandrite-laser-for-treatment-of-wrinkles
#7
Robert A Weiss, David H McDaniel, Margaret A Weiss, Anne Marie Mahoney, Karen L Beasley, Christian R Halvorson
INTRODUCTION: Picosecond lasers have been reported to be effective for removal of tattoo pigment. This prospective study evaluated the efficacy and safety of the treatment of peri-oral and -ocular wrinkles using a novel diffractive lens array coupled with a picosecond 755 nm alexandrite laser. METHODS: Forty female subjects presenting with wrinkles from photodamage were enrolled in an IRB approved study. Subjects received four picosecond diffractive lens array treatments to the full face at 1 month intervals...
September 29, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27641753/thymus-vulgaris-alleviates-uvb-irradiation-induced-skin-damage-via-inhibition-of-mapk-ap-1-and-activation-of-nrf2-are-antioxidant-system
#8
Zhengwang Sun, Sang Yong Park, Eunson Hwang, Mengyang Zhang, Seul A Seo, Pei Lin, Tae-Hoo Yi
Solar ultraviolet (UV) radiation-induced reactive oxidative species is mainly responsible for the development of photoageing. Rosmarinic acid was one of the main bioactive components detected in Thymus vulgaris (TV) we extracted. In this study, UVB-induced skin damages have been shown to be ameliorated by treatment with TV in hairless mice (HR-1) skin, demonstrated by decreased matrix metalloproteinases (MMPs) and increased collagen production. However, the underlying molecular mechanism on which TV acted was unclear...
September 19, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27640402/objective-severity-does-not-capture-the-impact-of-rosacea-acne-scarring-and-photoaging-in-patients-seeking-laser-therapy
#9
C L Thomas, B Kim, J Lam, S Richards, A See, S Kalouche, R D Paver, P Fernández Peñas
BACKGROUND: Measures of quality of life (QOL) and patient satisfaction are of great importance in dermatology, as both impact upon treatment adherence and health outcomes. Patients' assessment of QOL often differs from their doctors' predictions and their assessments of skin disease severity do not correlate with patients' own perceptions. The development of laser technology has facilitated successful treatment of many skin conditions, but studies on patient satisfaction are lacking. OBJECTIVES: Our aim was to determine the extent of discordance between patient and dermatologist-assessed disease severity and assess the impact of acne scarring, rosacea and photoaging on QOL...
September 18, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27638433/the-dark-side-of-the-light-phototherapy-adverse-effects
#10
Margarida Moura Valejo Coelho, Margarida Apetato
Phototherapy is a valuable therapeutic tool in Dermatology, but there may be drawbacks. Acute and long-term adverse effects, of variable severity, include skin erythema, xerosis, pruritus, blistering, altered pigmentation, photoaging, and photocarcinogenesis. Despite concerns over the carcinogenic potential of ultraviolet radiation, most studies have not found an increased risk of non-melanoma or melanoma skin cancer in patients treated with ultraviolet B (broadband and narrowband) and ultraviolet A1 phototherapy...
September 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27609754/protective-effect-of-cornus-walteri-wangerin-leaf-against-uvb-irradiation-induced-photoaging-in-human-reconstituted-skin
#11
Hyun-Chul Park, Taek Kyu Jung, Mi Jin Kim, Kyung-Sup Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus walteri Wangerin has been used in oriental traditional medicine for the treatment of antidiarrheal and inflammation. AIM OF THE STUDY: The efficacy of Cornus walteri Wangerin on skin anti-photoaging was investigated. MATERIALS AND METHODS: Hydrolyzed Cornus walteri Wangerin leaf was tested for the anti-photoaging effects against ultraviolet B (UVB)-induced matrix metalloproteinase (MMP)-1, pro-inflammatory cytokines using human reconstituted skin (KeraSkin(TM)-FT) and also tested for elastase activity in vitro...
September 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27602981/the-effects-of-a-daily-skincare-regimen-on-maintaining-the-benefits-obtained-from-previous-chemical-resurfacing-treatments
#12
Suzanne Bruce, Wendy Roberts, Craig Teller, Lora Colvan
BACKGROUND: Chemical peels are versatile treatments that involve chemical exfoliation of the skin for cosmetic improvement. Deeper peels produce more significant results, but can be associated with longer healing time and potential complications. Novel chemical resurfacing treatments (AGE and MELA) were developed in Europe to produce skin resurfacing via controlled inflammation to promote cell regeneration with minimum negative effects associated with conventional peelings. The AGE Resurfacing regimen is indicated for the treatment of photoaging, and consists of multi-ingredient peeling solution with trichloroacetic acid, pyruvic acid, salicylic acid, mandelic acid, and lactobionic acid...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27598132/novel-anti-melanogenesis-properties-of-polydeoxyribonucleotide-a-popular-wound-healing-booster
#13
Tai Kyung Noh, Bo Young Chung, Su Yeon Kim, Mi Hye Lee, Moon Jung Kim, Choon Shik Youn, Mi Woo Lee, Sung Eun Chang
Polydeoxyribonucleotide (PDRN), a deoxyribonucleotide polymer, is popularly used for faster healing of cutaneous wounds and boosting of neocollagenesis of photoaged skin among current dermatologic practitioners. Some patients receiving PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP). To investigate the effect of PDRN on cutaneous melanogenesis, we examined the effect of PDRN and an available product (Placentex(®)) containing PDRN on melanogenesis using human melanocytes-keratinocytes cocultures and mouse melanocytes...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27579986/attenuating-properties-of-agastache-rugosa-leaf-extract-against-ultraviolet-b-induced-photoaging-via-up-regulating-glutathione-and-superoxide-dismutase-in-a-human-keratinocyte-cell-line
#14
Yuri Oh, Hye-Won Lim, Yu-Hua Huang, Hee-Souk Kwon, Chang Duck Jin, Kyunghoon Kim, Chang-Jin Lim
Agastache rugosa Kuntze, known as a Korean mint, is an herbal medicine that has been used for the treatment of diverse kinds of symptoms in traditional medicine. This work was undertaken to assess the protective properties of A. rugosa leaves against UV-B-induced photoaging in HaCaT keratinocytes. They were evaluated via analyzing reactive oxygen species (ROS), promatrix metalloproteinase-2 (proMMP-2) and -9 (proMMP-9), total glutathione (GSH), total superoxide dismutase (SOD), cellular viability, flavonoid content and in vitro radical scavenging activity...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27549663/mesenchymal-stromal-cells-properties-and-role-in-management-of-cutaneous-diseases
#15
Kevin Kim, Gonzalo Blasco-Morente, Natividad Cuende, Salvador Arias-Santiago
This review describes the current understanding and the potential use of mesenchymal stromal cells (MSCs) in cell-based therapies for clinical management of difficult wounds and other dermatoses. MSCs have been shown to possess many advantageous properties that make them a promising therapeutic modality in dermatology still under investigation. In fact, MSCs' ability to promote wound healing through its paracrine function and pro-angiogenic properties have generated increasing interest for treating acute and chronic wounds...
August 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27539898/increased-susceptibility-to-oxidative-stress-and-ultraviolet-a-induced-apoptosis-in-fibroblasts-in-atypical-progeroid-syndrome-atypical-werner-syndrome-with-lmna-mutation
#16
Sei-Ichiro Motegi, Akihiko Uchiyama, Kazuya Yamada, Sachiko Ogino, Yoko Yokoyama, Buddhini Perera, Yuko Takeuchi, Osamu Ishikawa
Atypical progeroid syndrome (APS), including atypical Werner syndrome (AWS), is a disorder of premature ageing caused by mutation of the lamin A gene, the same causal gene involved in Hutchinson-Gilford syndrome (HGS). We previously reported the first Japanese case of APS/AWS with a LMNA mutation (p.D300N). Recently, it has been reported that UVA induced abnormal truncated form of lamin A, called progerin, as well as HGS-like abnormal nuclear structures in normal human fibroblasts, being more frequent in the elderly, suggesting that lamin A may be involved in the regulation of photoageing...
August 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27518833/photodynamic-therapy-using-intense-pulsed-light-for-treating-actinic-keratoses-and-photoaged-skin-of-the-dorsal-hands-a-randomized-placebo-controlled-study
#17
E Kohl, C Popp, F Zeman, P Unger, M Koller, M Landthaler, S Karrer, R-M Szeimies
BACKGROUND: The efficacy of photodynamic therapy (PDT) with intense pulsed light (IPL) has been shown for treating actinic keratoses (AK) and improving photoaged skin in the face but not yet on the dorsal hands. OBJECTIVE: To evaluate the efficacy of PDT with IPL for treating AK of the dorsal hands, inducing neocollagenesis, and improving photoaged skin. METHODS: In this prospective, randomized, placebo-controlled, monocentric, within-patient, observer-blinded trial, patients with 1 to 4 mild-to-moderate AK on the dorsal hands were randomly allocated to two different treatment groups: methyl aminolevulinate (MAL) and IPL (λ ≥600nm, 16...
August 12, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27514487/protective-effect-of-curcumin-against-acute-ultraviolet-b-irradiation-induced-photo-damage
#18
Huaping Li, Aili Gao, Na Jiang, Qing Liu, Bihua Liang, Runxiang Li, Erting Zhang, Zhenjie Li, Huilan Zhu
Ultraviolet B (UVB) irradiation is one of the most dangerous insults for skin, and causes sunburn, erythema, photoaging and photocarcinogenesis. Curcumin (diferuloylmethane), a yellow spice derived from dried rhizomes of Curcuma longa, has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anticoagulant and anti-infective effects. However, the protective effects of curcumin against acute photo-damage are poorly understood. In this study, we investigated the photo-protective effects of curcumin against UVB induced acute photo-damage in hairless mice and immortalized human keratinocytes (HaCaT)...
August 12, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27496663/fifty-years-of-research-and-development-of-cosmeceuticals-a-contemporary-review
#19
Chun-Man Lee
Facial rejuvenation can be categorized into skincare and facial contouring. Research and development of cosmeceuticals is aimed at addressing the major signs of photoaging: wrinkles, dyschromia, and sallowness. Assessment of photoaging comes in clinical and photographic forms; a photonumeric scale developed by Griffiths et al. has been assured of its validity and reliability for the assessment of severity of photoaging in qualitative studies. Treatment of photoaging comes in two categories: preventive and reversal of signs; whilst sunfactors are the most efficient and essential in preventing photodamage, research and development of cosmeceuticals for facial rejuvenation has been robust, thanks to several landmark studies in the last fifty years, funded by some of the forerunners in contemporary cosmetic industry...
August 6, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27486771/the-underlying-mechanism-of-proinflammatory-nf-%C3%AE%C2%BAb-activation-by-the-mtorc2-akt-ikk%C3%AE-pathway-during-skin-aging
#20
Yeon Ja Choi, Kyoung Mi Moon, Ki Wung Chung, Ji Won Jeong, Daeui Park, Dae Hyun Kim, Byung Pal Yu, Hae Young Chung
Mammalian target of rapamycin complex 2 (mTORC2), one of two different enzymatic complexes of mTOR, regulates a diverse set of substrates including Akt. mTOR pathway is one of well-known mediators of aging process, however, its role in skin aging has not been determined. Skin aging can be induced by physical age and ultraviolet (UV) irradiation which are intrinsic and extrinsic factors, respectively. Here, we report increased mTORC2 pathway in intrinsic and photo-induced skin aging, which is implicated in the activation of nuclear factor-κB (NF-κB)...
July 29, 2016: Oncotarget
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