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https://www.readbyqxmd.com/read/29154501/challenges-to-laser-assisted-drug-delivery-applying-theory-to-clinical-practice
#1
Omer Ibrahim, Emily Wenande, Sara Hogan, Kenneth A Arndt, Merete Haedersdal, Jeffrey S Dover
BACKGROUND: The percutaneous penetration of topically applied compounds can be enhanced using external chemical or physical sources and thus laser-assisted drug delivery is a burgeoning area of interest within the field of dermatology. OBJECTIVES: This article briefly discusses the mechanism of laser-assisted drug delivery and expands upon the challenges and safety issues that may arise in the clinical implementation of this modality. RESULTS: The existing literature demonstrates that investigators and clinicians in dermatology have successfully delivered anti-inflammatory, anti-neoplastic, and anti-oxidative medications transdermally for the treatment of a variety of conditions including scarring, photoageing, and cutaneous neoplasia...
November 20, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29141061/a-randomized-investigator-blinded-comparison-of-two-topical-regimens-in-fitzpatrick-skin-types-iii-vi-with-moderate-to-severe-facial-hyperpigmentation
#2
Monique J Vanaman Wilson, Isabela T Jones, Joanna Bolton, Lisa Larsen, Douglas C Wu, Mitchel P Goldman
<p>Purpose: Though hydroquinone (HQ) remains the gold standard for treatment of hyperpigmentation, concerns about its safety have prompted the development of HQ-free topical skin lightening systems. OBJECTIVE: To compare the efficacy and tolerability of a new HQ-free system and a popular HQ-based system for the improvement of facial hyperpigmentation and photoaging in darker skin types. METHODS: This investigator-blinded trial randomized 30 subjects of Fitzpatrick skin types III to VI with moderate to severe hyperpigmentation to a new 7-product HQ-free system or a 7-product HQ-based system for 12 weeks...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141055/treatment-of-photoaging-with-a-dual-wavelength-532-nm-and-1-064-nm-picosecond-domain-laser-producing-a-fractionated-treatment-beam-using-a-holographic-optic
#3
Eric F Bernstein, Kevin T Schomacker, Amit S Paranjape, Jayant D Bhawalkar
<p>BACKGROUND: A dual-wavelength, picosecond-domain, fractionated laser delivering 1,064nm and 532nm laser energy through a holographic optic was investigated for safety and effectiveness at improving the appearance of chronic photoaging. MATERIALS AND METHODS: A total of 27 subjects were enrolled with 24 completing the study, and 14 subjects were treated with 1,064 nm and 10 with 532 nm. The 1,064 nm-treated subjects received 5 monthly treatments while the 532 nm-treated subjects received 4 monthly treatments...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29128803/the-effect-of-dehydroglyasperin-c-on-uvb-mediated-mmps-expression-in-human-hacat-cells
#4
Song Hua Xuan, Young Min Park, Ji Hoon Ha, Yoon Ju Jeong, Soo Nam Park
BACKGROUND: The ultraviolet B (UVB) from solar radiation increases the generation of reactive oxygen species (ROS), which mediate the production of matrix metalloproteinases (MMPs), and acts mainly on the epidermis layer of the skin. This study was aimed at assessing the anti-photoaging effects of dehydroglyasperin C isolated from Glycyrrhiza uralensis Fisch on MMPs levels in HaCaT human keratinocytes and to elucidate the underlying mechanism. METHODS: The cell viability was measured by MTT assay...
May 31, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128706/consumption-of-ellagic-acid-and-dihydromyricetin-synergistically-protects-against-uv-b-induced-photoaging-possibly-by-activating-both-tgf-%C3%AE-1-and-wnt-signaling-pathways
#5
Na Rang Moon, Suna Kang, Sunmin Park
Ellagic acid (EGA) and dihydromyricetin (DHM) are both found in fruits and vegetables are used for anti-aging treatment for the skin. The anti-photoaging efficacy of EGA and DHM was investigated in UV-B irradiated skin in vivo and the involvement of transforming growth factor (TGF)-β1 and wnt signaling pathways were examined in vitro. HaCaT cells were treated with either 50μM EGA, 50μM DHM or 25μM EGA+25μM DHM before 100mJ/cm(2) UV-B exposure, and then oxidative stress and inflammation was measured. The involvement of TGF-β1 and wnt signaling was measured using their inhibitors, respectively, in HaCaT cells...
November 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29107927/photochemoprotective-effect-of-a-fraction-of-a-partially-purified-extract-of-byrsonima-crassifolia-leaves-against-uvb-induced-oxidative-stress-in-fibroblasts-and-hairless-mice
#6
Rebeca Oliveira de Souza, Geórgia de Assis Dias Alves, Ana Luiza Scarano Aguillera, Hervé Rogez, Maria José Vieira Fonseca
Ultraviolet B (UVB) irradiation increases the risk of various skin disorders, leading to inflammation and oxidative stress and thereby increasing the risk of skin photoaging and carcinogenesis. The use of photochemoprotectors such as natural products with antioxidant and anti-inflammatory properties represents a strategy for preventing UVB-induced skin damage. We investigated the photochemoprotective effect of a fraction of a partially purified extract of Byrsonima crassifolia leaves (BCF) on fibroblasts and hairless mice exposed to UVB radiation...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29079536/restoration-of-skin-pigmentation-after-deep-partial-or-full-thickness-burn-injury
#7
Niann-Tzyy Dai, Hsin-I Chang, Yi-Wen Wang, Keng-Yen Fu, Tai-Chun Huang, Nien-Chi Huang, Jhen-Kai Li, Pai-Shan Hsieh, Lien-Guo Dai, Chao-Kuei Hsu, Peter K Maitz
Significant skin pigmentation changes occur when patients suffer deep burn injuries. These pigmentation disorders may cause not only cosmetic and psychological issues, but more importantly it increases the risk of skin cancer or photoaging. Severe burns significantly effect on the process of repigmentation as the pigmentation is tightly regulated by cell proliferation and differentiation of melanocytes and melanocyte stem cells which are housing in the epidermis and hair follicles of the skin. In the present review, we discuss the possible mechanisms to replenish the melanocytes from the healthy epidermis and hair follicles surrounding burn wounds...
October 24, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29070025/daylight-photodynamic-therapy-versus-cryosurgery-for-the-treatment-and-prophylaxis-of-actinic-keratoses-of-the-face%C3%A2-%C3%A2-protocol-of-a-multicenter-prospective-randomized-controlled-two-armed-study
#8
E Kohl, M Koller, F Zeman, R-M Szeimies, W G Philipp-Dormston, W Prager, P A Gerber, S Karrer
BACKGROUND: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated. METHODS/DESIGN: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery...
October 25, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/29069654/expression-profiles-of-long-noncoding-rna-in-uva-induced-human-skin-fibroblasts
#9
Yue Zheng, Qingfang Xu, Yating Peng, Zijian Gong, Haiyan Chen, Wei Lai, Howard I Maibach
BACKGROUND: Long noncoding RNA (lncRNA) are differentially expressed across stages of differentiation and development, but the role of lncRNA in human skin photoaging mechanisms remains poorly understood. OBJECTIVE: This study aimed to determine lncRNA expression changes in human dermal fibroblasts (HDF) induced by repeated UVA irradiation and to explore correlations between lncRNA and skin photoaging prognosis. METHODS: In the UVA-HDF group, HDF were subjected to repeated UVA irradiation (10 J/cm2 UVA twice daily for 7 days); in the control group, HDF received no irradiation...
October 26, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29064096/chemical-peels-a-review-of-current-practice
#10
REVIEW
Alicia A O'Connor, Patricia M Lowe, Stephen Shumack, Adrian C Lim
Chemical peels belong to a group of cutaneous resurfacing procedures that are used in the treatment of photoageing, inflammatory dermatoses, epidermal proliferations, pigmentary disorders and scarring. This review describes best current practice, highlights recent advances in chemical peel technology and discusses the recommended uses for different peel types. It also presents the results of a survey of the chemical peeling practices of 30 Australian dermatologists.
October 24, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29053534/comparison-of-moderate-and-high-energy-of-a-nano-fractional-radiofrequency-treatment-on-a-photoaging-hairless-mice-model
#11
Wenjia Sun, Chengfeng Zhang, Juemin Zhao, Jiaqiang Wu, Leihong Xiang
BACKGROUND: Fractional radiofrequency (FRF) has been widely used in skin rejuvenation. To explore optimal settings, it is important to compare different treatment parameters. OBJECTIVE: This study was designed to compare the effect of moderate-energy and high-energy FRF treatment on a hairless mice model. METHODS: Fifteen photoaged hairless mice were assigned to 3 groups: control, moderate energy, and high energy. Two treatment sessions (T × 1 and T × 2) were performed at 1-month interval...
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29045012/photodynamic-therapy-inhibits-melanogenesis-through-paracrine-effects-by-keratinocytes-and-fibroblasts
#12
Sue Kyung Kim, Seung-Jae Oh, Se-Yeon Park, Woo-Jung Kim, You-Sun Kim, You Chan Kim
Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In this study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes (MCs) in vitro and in vivo. Exposure of MCs to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing MCs to conditioned media of PDT-treated keratinocytes or dermal fibroblasts...
October 17, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29040421/effect-of-use-of-platelet-rich-plasma-prp-in-skin-with-intrinsic-aging-process
#13
Luiz Charles-de-Sá, Natale Ferreira Gontijo-de-Amorim, Christina Maeda Takiya, Radovan Borojevic, Donatella Benati, Paolo Bernardi, Andrea Sbarbati, Gino Rigotti
Background: In previous papers, we demonstrated that the treatment of human photoaged skin with stromal-vascular fraction-enriched fat or expanded adipose-derived stem cells showed a decrease of elastosis and the appearance of new oxytalan elastic fibers in dermis and an increase in the vascular network. The utilization of fat plus platelet-rich plasma (PRP) led to an increase in the vascular permeability and reactivity of the nervous component. Objectives: The purpose of this study was to analyze the histologic and ultrastructural changes of human skin after the injection of only PRP in the retroauricular area that was not exposed to sun and did not present the photoaging process, in comparison with our previous results...
September 7, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29021691/photoprotective-effects-of-topical-ginseng-leaf-extract-using-ultraflo-l-against-uvb-induced-skin-damage-in-hairless-mice
#14
Yang Hee Hong, Hyun-Sun Lee, Eun Young Jung, Sung-Hee Han, Yooheon Park, Hyung Joo Suh
BACKGROUND: Abnormal activation of matrix metalloproteinases (MMPs) plays an important role in UV-induced wrinkle formation, which is a major dermatological problem. This formation occurs due to the degeneration of the extracellular matrix (ECM). In this study, we investigated the cutaneous photoprotective effects of Ultraflo L treated ginseng leaf (UTGL) in hairless mice. METHODS: SKH-1 hairless mice (6 weeks of age) were randomly divided into four groups (8 mice/group)...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28988108/salubrinal-protects-human-skin-fibroblasts-against-uvb-induced-cell-death-by-blocking-endoplasmic-reticulum-er-stress-and-regulating-calcium-homeostasis
#15
Chao Ji, Bo Yang, Shu-Ying Huang, Jin-Wen Huang, Bo Cheng
The role of UVB in skin photo damages has been widely reported. Overexposure to UVB will induce severe DNA damages in epidermal cells and cause most cytotoxic symptoms. In the present study, we tested the potential activity of salubrinal, a selective inhibitor of Eukaryotic Initiation Factor 2 (eIF2) -alpha phosphatase, against UV-induced skin cell damages. We first exposed human fibroblasts to UVB radiation and evaluated the cytosolic Ca(2+) level as well as the induction of ER stress. We found that UVB radiation induced the depletion of ER Ca(2+) and increased the expression of ER stress marker including phosphorylated PERK, CHOP, and phosphorylated IRE1α...
December 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28979661/a-prospective-pilot-clinical-trial-to-evaluate-the-efficacy-and-safety-of-topical-therapy-with-ingenol-mebutate-gel-0-015-for-actinic-keratosis-on-an-expanded-area-of-the-chest
#16
Douglas C Wu, Isabella Guiha, Mitchel P Goldman
BACKGROUND: Ingenol mebutate gel 0.05% once daily for two consecutive days provides high clearance rates for actinic keratosis on a 25cm(2) area of the chest. However, it may cause intense local skin responses. OBJECTIVE: The objective of this study was to determine whether a lower dose of ingenol mebutate gel 0.015% could clear actinic keratosis on the chest with acceptable tolerability and a possible beneficial effect on photodamage and cosmesis. DESIGN: This was a noncomparative, open-label study (NCT02446223)...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28962194/polycomb-group-proteins-novel-molecules-associated-with-ultraviolet-a-induced-photoaging-of-human-skin
#17
Zhuoxia Wu, Lianbo Zhang
Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI-1 and EZH2) were altered...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28948464/enhancement-of-protective-effects-of-radix-scutellariae-on-uvb-induced-photo-damage-in-human-hacat-keratinocytes
#18
Yu-Shuai Wang, Jin-Gyeong Cho, Eun-Son Hwang, Jung-Eun Yang, Wei Gao, Min-Zhe Fang, Sheng-Dao Zheng, Tae-Hoo Yi
Radix Scutellariae (RS) has long been used in the treatment of inflammatory and allergic diseases. Its main flavonoids, baicalin (BG) and wogonoside (WG), can be hydrolyzed into their corresponding aglycones, baicalein (B) and wogonin (W). In this study, we developed a safe and effective method of transforming these glycosides using Peclyve PR. The transformation rate of BG and WG reached 98.5 and 98.1%, respectively, with 10% enzyme at 40 °C for 60 h. Furthermore, we compared the anti-photoaging activity of RS before and after enzyme treatment, as well as their respective main components, in UVB-irradiated HaCaT cells...
September 26, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28917186/compounds-isolated-from-eriobotrya-deflexa-leaves-protect-against-ultraviolet-radiation-b-induced-photoaging-in-human-fibroblasts
#19
Chung-Yu Huang, Yi-Tzu Lin, Hsiang-Chun Kuo, Wen-Fei Chiou, Mei-Hsien Lee
Ultraviolet (UV) irradiation leads to skin photoaging because of the upregulation of matrix metalloproteinase (MMP)-1 and downregulation of type I collagen and tissue inhibitor of metalloproteinase (TIMP)-1. Eriobotrya deflexa (Hemsl.) Nakai (Rosaceae) is a flowering plant endemic to Taiwan, and its leaves have been used as an expectorant and in antitussive folk remedy. Our previous studies have demonstrated that an E. deflexa leaf extract functions as a free radical scavenger. The current evaluated the antiphotoaging effect of partitioned fractions and specific compounds from the leaves of E...
October 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28906033/collagen-peptides-modulates-the-metabolism-of-extracellular-matrix-by-human-dermal-fibroblasts-derived-from-sun-protected-and-sun-exposed-body-sites
#20
Vivian Zague, Jonatas Bussador do Amaral, Paula Rezende Teixeira, Evandro Luis de Oliveira Niero, Camila Lauand, Glaucia Maria Machado-Santelli
Clinical data published in recent years has demonstrated positive effects of collagen hydrolysate (CH) on skin aging clinical signs. CH use as food supplement has a long history; however, few studies have addressed the underlying purpose of CH on the cellular and molecular biology of skin cells that could elucidate clinical improvement findings. Wide diversity of characteristics has been reported for dermal fibroblasts derived from different body sites and it is unknown whether collagen peptides could modulate differently cells from chronological aged and photoaged skin areas...
September 14, 2017: Cell Biology International
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