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Matrix metalloproteinases photoaging

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https://www.readbyqxmd.com/read/27880964/protective-effects-of-standardized-siegesbeckia-glabrescens-extract-and-its-active-compound-kirenol-against-uvb-induced-photoaging-through-inhibition-of-mapk-nf-%C3%AE%C2%BAb-pathways
#1
Jongwook Kim, Mi-Bo Kim, Jun Gon Yun, Jae Kwan Hwang
Anti-photoaging effects of standardized Siegesbeckia glabrescens extract (SGE) and its major active compound kirenol were investigated using Hs68 human dermal fibroblasts and hairless mice, respectively. UVB-irradiated hairless mice that received oral SGE (600 mg/kg/day) showed reduced wrinkle formation and skinfold thickness compared to the UVB-irradiated control. Furthermore, SGE treatment increased the mRNA levels of collagen synthesis genes (COL1A1, COL3A1, COL4A1, and COL7A1) and activated antioxidant enzyme (catalase), while suppressing the matrix metalloproteinases (MMPs; MMP-2, -3, -9, and -13) expression...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27854351/a-mixture-of-extracts-of-kochia-scoparia-and-rosa-multiflora-with-ppar-%C3%AE-%C3%AE-dual-agonistic-effects-prevents-photoaging-in-hairless-mice
#2
Hyerin Jeon, Dong Hye Kim, Youn-Hwa Nho, Ji-Eun Park, Su-Nam Kim, Eung Ho Choi
Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as Kochia scoparia and Rosa multiflora, have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm² and UVB 40 mJ/cm² three times a week for 8 weeks...
November 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27847530/aqueous-extract-of-clerodendranthus-spicatus-exerts-protective-effect-on-uv-induced-photoaged-mice-skin
#3
Lan Wang, Xie Zhang, Yong-Xian Li, Lie-Qiang Xu, Cai-Lan Li, Zhen-Biao Zhang, Jia-Li Liang, Zi-Ren Su, Hui-Fang Zeng, Yu-Cui Li
Clerodendranthus spicatus (Thunb.) C.Y.Wu (CS) is commonly used to treat kidney diseases in traditional Chinese medicine for its prominent anti-inflammatory effect and nourishing function to kidneys. In this study, aqueous extract of CS was assessed for its protective effect on UV-induced skin damage of mice. The chemical compositions of CS aqueous extract were determined by HPLC-ESI-MS/MS, in which 10 components were identified. During the experimental period, CS (0.9, 1.8, and 3.6 g/mL) was externally applied to shaved dorsal skins of mice prior to UV irradiation, daily for ten weeks...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27768951/protective-effect-of-gelatin-peptides-from-pacific-cod-skin-against-photoaging-by-inhibiting-the-expression-of-mmps-via-mapk-signaling-pathway
#4
Tiejun Chen, Hu Hou, Yan Fan, Shikai Wang, Qianru Chen, Leilei Si, Bafang Li
Chronic exposure to ultraviolet (UV) irradiation causes skin photoaging. This study was undertaken to identify the anti-photoaging mechanisms of gelatin hydrolysate (CH) derived from pacific cod skin. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) and ELISA assays were used to investigate the effects of CH on matrix metalloproteinases (MMPs) and the signaling pathways after UV irradiation by using a mice skin photoaging model. The average molecular weight of CH was 1200Da, and 273/1000 residues were hydrophobic, Gly-Pro and Gly-Leu sequences and Arg at C-terminus appeared frequently in CH...
October 14, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27765346/dietary-foeniculum-vulgare-mill-extract-attenuated-uvb-irradiation-induced-skin-photoaging-by-activating-of-nrf2-and-inhibiting-mapk-pathways
#5
Zhengwang Sun, Sang Yong Park, Eunson Hwang, Bom Park, Seul A Seo, Jin-Gyeong Cho, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Foeniculum vulgare Mill (FV) has long been prescribed in traditional medicine due to its antioxidant anti-inflammatory properties. However, little research has been done on the use of FV to alleviate changes in UVB-induced photoaging PURPOSE: This study was to investigate the photoprotective effects and mechanism of FV in vitro and in vivo. METHODS: The anti-photoaging effect of FV was assessed in normal human dermal fibroblasts (NHDFs) in vitro. The secretion of reactive oxygen species (ROS), lactate dehydrogenase (LDH), GSH, matrix metalloproteinases (MMPs), procollagen type I, IL-6 and transforming growth factor-β1 (TGF-β1) were measured by kits...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27732760/daily-ingestion-of-aloe-vera-gel-powder-containing-aloe-sterols-prevents-skin-photoaging-in-ovx-hairless-mice
#6
Ruiqing Yao, Miyuki Tanaka, Eriko Misawa, Marie Saito, Kazumi Nabeshima, Koji Yamauchi, Fumiaki Abe, Yuki Yamamoto, Fukumi Furukawa
Estrogen deficiencies associated with menopause accelerate spontaneous skin aging and stimulate the ultraviolet (UV) irradiation-induced photoaging of skin. However, food compositions with the potential to ameliorate the UV irradiation-induced acceleration of skin aging with menopause have not yet been investigated in detail. In the present study, we examined the ability of plant sterols derived from Aloe vera gel to prevent the UV irradiation-induced acceleration of skin aging in ovariectomized mice. Skin transepidermal water loss (TEWL) was significantly higher in the ovariectomy group than in the sham operation group following UVB irradiation, whereas skin elasticity was significantly lower...
October 12, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27641753/thymus-vulgaris-alleviates-uvb-irradiation-induced-skin-damage-via-inhibition-of-mapk-ap-1-and-activation-of-nrf2-are-antioxidant-system
#7
Zhengwang Sun, Sang Yong Park, Eunson Hwang, Mengyang Zhang, Seul A Seo, Pei Lin, Tae-Hoo Yi
Solar ultraviolet (UV) radiation-induced reactive oxidative species is mainly responsible for the development of photoageing. Rosmarinic acid was one of the main bioactive components detected in Thymus vulgaris (TV) we extracted. In this study, UVB-induced skin damages have been shown to be ameliorated by treatment with TV in hairless mice (HR-1) skin, demonstrated by decreased matrix metalloproteinases (MMPs) and increased collagen production. However, the underlying molecular mechanism on which TV acted was unclear...
September 19, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27611371/activation-of-peroxisome-proliferator-activated-receptor-alpha-improves-aged-and-uv-irradiated-skin-by-catalase-induction
#8
Mi Hee Shin, Se-Rah Lee, Min-Kyoung Kim, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear hormone receptor involved in the transcriptional regulation of lipid metabolism, fatty acid oxidation, and glucose homeostasis. Its activation stimulates antioxidant enzymes such as catalase, whose expression is decreased in aged human skin. Here we investigated the expression of PPARα in aged and ultraviolet (UV)-irradiated skin, and whether PPARα activation can modulate expressions of matrix metalloproteinase (MMP)-1 and procollagen through catalase regulation...
2016: PloS One
https://www.readbyqxmd.com/read/27609754/protective-effect-of-cornus-walteri-wangerin-leaf-against-uvb-irradiation-induced-photoaging-in-human-reconstituted-skin
#9
Hyun-Chul Park, Taek Kyu Jung, Mi Jin Kim, Kyung-Sup Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus walteri Wangerin has been used in oriental traditional medicine for the treatment of antidiarrheal and inflammation. AIM OF THE STUDY: The efficacy of Cornus walteri Wangerin on skin anti-photoaging was investigated. MATERIALS AND METHODS: Hydrolyzed Cornus walteri Wangerin leaf was tested for the anti-photoaging effects against ultraviolet B (UVB)-induced matrix metalloproteinase (MMP)-1, pro-inflammatory cytokines using human reconstituted skin (KeraSkin(TM)-FT) and also tested for elastase activity in vitro...
September 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27598131/the-methoxyflavonoid-isosakuranetin-suppresses-uv-b-induced-matrix-metalloproteinase-1-expression-and-collagen-degradation-relevant-for-skin-photoaging
#10
Hana Jung, Eunjoo H Lee, Tae Hoon Lee, Man-Ho Cho
Solar ultraviolet (UV) radiation is a main extrinsic factor for skin aging. Chronic exposure of the skin to UV radiation causes the induction of matrix metalloproteinases (MMPs), such as MMP-1, and consequently results in alterations of the extracellular matrix (ECM) and skin photoaging. Flavonoids are considered as potent anti-photoaging agents due to their UV-absorbing and antioxidant properties and inhibitory activity against UV-mediated MMP induction. To identify anti-photoaging agents, in the present study we examined the preventative effect of methoxyflavonoids, such as sakuranetin, isosakuranetin, homoeriodictyol, genkwanin, chrysoeriol and syringetin, on UV-B-induced skin photo-damage...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27573915/anti-wrinkle-effects-of-sargassum-muticum-ethyl-acetate-fraction-on-ultraviolet-b-irradiated-hairless-mouse-skin-and-mechanistic-evaluation-in-the-human-hacat-keratinocyte-cell-line
#11
Jae Hyoung Song, Mei Jing Piao, Xia Han, Kyoung Ah Kang, Hee Kyoung Kang, Weon Jong Yoon, Mi Hee Ko, Nam Ho Lee, Mi Young Lee, Sungwook Chae, Jin Won Hyun
The present study investigated the photoprotective properties of the ethyl acetate fraction of Sargassum muticum (SME) against ultraviolet B (UVB)‑induced skin damage and photoaging in a mouse model. HR‑1 strain hairless male mice were divided into three groups: An untreated control group, a UVB‑irradiated vehicle group and a UVB‑irradiated SME group. The UVB‑irradiated mice in the SME group were orally administered with SME (100 mg/kg body weight in 0.1 ml water per day) and then exposed to radiation at a dose of 60‑120 mJ/cm2...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27556138/catechol-based-matrix-metalloproteinase-inhibitors-with-additional-antioxidative-activity
#12
Marilena Tauro, Antonio Laghezza, Fulvio Loiodice, Luca Piemontese, Alessia Caradonna, Davide Capelli, Roberta Montanari, Giorgio Pochetti, Antonella Di Pizio, Mariangela Agamennone, Cristina Campestre, Paolo Tortorella
New catechol-containing chemical entities have been investigated as matrix metalloproteinase inhibitors as well as antioxidant molecules. The combination of the two properties could represent a useful feature due to the potential application in all the pathological processes characterized by increased proteolytic activity and radical oxygen species (ROS) production, such as inflammation and photoaging. A series of catechol-based molecules were synthesized and tested for both proteolytic and oxidative inhibitory activity, and the detailed binding mode was assessed by crystal structure determination of the complex between a catechol derivative and the matrix metalloproteinase-8...
August 24, 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/27539903/a-polymethoxyflavone-mixture-extracted-from-orange-peels-suppresses-the-uvb-induced-expression-of-mmp-1
#13
Norihiro Yoshizaki, Takahiro Fujii, Ron Hashizume, Hitoshi Masaki
Ultraviolet (UV) B is the main cause of skin photoageing, which has characteristic features such as deep wrinkles. UVB increases the expression of matrix metalloproteinases (MMPs) in the skin and can cause wrinkles by disrupting components of the extracellular matrix, such as collagen fibres. We now report that a polymethoxyflavone (PMF) mixture, extracted from orange peels, suppresses the UVB-induced expression of MMP-1 that involves the inhibition of c-jun N-terminal kinase (JNK) activity. Furthermore, the PMF mixture also inhibits the UVB-induced phosphorylation of JNK...
August 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27539897/characterization-and-mechanisms-of-photoageing-related-changes-in-skin-damages-of-basement-membrane-and-dermal-structures
#14
REVIEW
Satoshi Amano
Sun-exposed skin is characterized by superficial changes such as wrinkles, sagging and pigmentary changes, and also many internal changes in the structure and function of epidermis, basement membrane (BM) and dermis. These changes (so-called photoageing) are predominantly induced by the ultraviolet (UV) component of sunlight. Epidermis of UV-irradiated skin produced several enzymes such as matrix metalloproteinases (MMPs), urinary plasminogen activator (uPA)/plasmin and heparanase, which degrade dermal collagen fibres and elastic fibres in the dermis, and components of epidermal BM...
August 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27486852/tiron-inhibits-uvb-induced-ap-1-binding-sites-transcriptional-activation-on-mmp-1-and-mmp-3-promoters-by-mapk-signaling-pathway-in-human-dermal-fibroblasts
#15
Jing Lu, Jia-Hui Guo, Xue-Liang Tu, Chao Zhang, Mei Zhao, Quan-Wu Zhang, Feng-Hou Gao
Recent research found that Tiron was an effective antioxidant that could act as the intracellular reactive oxygen species (ROS) scavenger or alleviate the acute toxic metal overload in vivo. In this study, we investigated the inhibitory effect of Tiron on matrix metalloproteinase (MMP)-1 and MMP-3 expression in human dermal fibroblast cells. Western blot and ELISA analysis revealed that Tiron inhibited ultraviolet B (UVB)-induced protein expression of MMP-1 and MMP-3. Real-time quantitative PCR confirmed that Tiron could inhibit UVB-induced mRNA expression of MMP-1 and MMP-3...
2016: PloS One
https://www.readbyqxmd.com/read/27484958/anti-photoaging-properties-of-the-phosphodiesterase-3-inhibitor-cilostazol-in-ultraviolet-b-irradiated-hairless-mice
#16
Ha Neui Kim, Chan Hee Gil, Yu Ri Kim, Hwa Kyoung Shin, Byung Tae Choi
We investigated whether cilostazol, an activator of cyclic adenosine monophosphate (cAMP)-dependent intracellular signaling, could inhibit ultraviolet B (UVB) irradiation-induced photoaging in HR-1 hairless mice. Cilostazol decreased wrinkle formation and skin thickness in UVB-irradiated mice, as well as increased staining of collagen fibers and inhibition of reactive oxygen species (ROS) formation in the skin. Moreover, the proteolytic activities of gelatinase matrix metalloproteinase (MMP)-9 and collagenase MMP-3 were significantly decreased in UVB-irradiated mice treated with cilostazol...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27473358/protective-effect-of-fermented-cyclopia-intermedia-against-uvb-induced-damage-in-hacat-human-keratinocytes
#17
A-Rang Im, Sung Hum Yeon, Jung Seung Lee, Key An Um, Young-Joon Ahn, Sungwook Chae
BACKGROUND: The fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, a herbal tea indigenous to South Africa. The aim of this study was to evaluate the protective effect of fermented honeybush extracts (FH ex) and scale-up fermented honeybush extracts (SFH ex) against ultraviolet B (UVB)-induced damage in HaCaT keratinocytes. To this end, we examined UVB-induced cell viability, antioxidant enzymes, and inflammatory mediators in HaCaT cells. METHODS: UVB significantly decreased HaCaT cell viability, whereas FH ex and SFH ex did not exhibit cytotoxic effects and increased the viability of the HaCaT cells...
July 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27466023/sclareol-isolated-from-salvia-officinalis-improves-facial-wrinkles-via-an-antiphotoaging-mechanism
#18
Ji-Eun Park, Kyung-Eun Lee, Eunsun Jung, Seunghyun Kang, Youn Joon Kim
BACKGROUND: Ultraviolet (UV) irradiation triggers skin photoaging processes, which disrupt the normal three-dimensional integrity of skin. UV-induced oxidative stress, both directly and indirectly, stimulates complex signaling pathways. UV radiation activates skin cell surface receptors on a molecular level and triggers severe changes in extracellular matrix (ECM) proteins, resulting in skin photoaging. AIMS: Sclareol isolated from Salvia officinalis is widely used as a fragrance material...
July 28, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27446272/potential-for-tyndalized-lactobacillus-acidophilus-as-an-effective-component-in-moisturizing-skin-and-anti-wrinkle-products
#19
A-Rang Im, Hui Seong Kim, Jin Won Hyun, Sungwook Chae
It is widely accepted that ultraviolet (UV) irradiation induces skin damage. In the present study, a UVB-induced hairless mouse model of skin photoaging was developed to determine whether tyndalized Lactobacillus acidophilus was able to significantly enhance the repair of photodamaged skin. To evaluate the effects of tyndalized L. acidophilus on UVB-induced skin-wrinkle formation in vivo, HR-1 hairless male mice were exposed to UVB radiation and orally administered tyndalized L. acidophilus. Compared with the control group, the UVB irradiation mice displayed a significant increase in transepidermal water loss and a reduction in skin hydration...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27428951/dermal-lipogenesis-inhibits-adiponectin-production-in-human-dermal-fibroblasts-while-exogenous-adiponectin-administration-prevents-against-uva-induced-dermal-matrix-degradation-in-human-skin
#20
Chien-Liang Fang, Ling-Hung Huang, Hung-Yueh Tsai, Hsin-I Chang
Adiponectin is one of the most abundant adipokines from the subcutaneous fat, and regulates multiple activities through endocrine, paracrine, or autocrine mechanisms. However, its expression in adipogenic induced fibroblasts, and the potential role in photoaging has not been determined. Here, human dermal fibroblasts, Hs68, were presented as a cell model of dermal lipogenesis through stimulation of adipogenic differentiation medium (ADM). Similar to other studies in murine pre-adipocyte models (i.e., 3T3-L1), Hs68 fibroblasts showed a tendency to lipogenesis based on lipid accumulation, triglyceride formation, and the expressions of PPAR-γ, lipoprotein lipase (LPL), and FABP4 mRNA...
2016: International Journal of Molecular Sciences
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