keyword
MENU ▼
Read by QxMD icon Read
search

Matrix metalloproteinases photoaging

keyword
https://www.readbyqxmd.com/read/28917186/compounds-isolated-from-eriobotrya-deflexa-leaves-protect-against-ultraviolet-radiation-b-induced-photoaging-in-human-fibroblasts
#1
Chung-Yu Huang, Yi-Tzu Lin, Hsiang-Chun Kuo, Wen-Fei Chiou, Mei-Hsien Lee
Ultraviolet (UV) irradiation leads to skin photoaging because of the upregulation of matrix metalloproteinase (MMP)-1 and downregulation of type I collagen and tissue inhibitor of metalloproteinase (TIMP)-1. Eriobotrya deflexa (Hemsl.) Nakai (Rosaceae) is a flowering plant endemic to Taiwan, and its leaves have been used as an expectorant and in antitussive folk remedy. Our previous studies have demonstrated that an E. deflexa leaf extract functions as a free radical scavenger. The current evaluated the antiphotoaging effect of partitioned fractions and specific compounds from the leaves of E...
September 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28906033/collagen-peptides-modulates-the-metabolism-of-extracellular-matrix-by-human-dermal-fibroblasts-derived-from-sun-protected-and-sun-exposed-body-sites
#2
Vivian Zague, Jonatas Bussador do Amaral, Paula Rezende Teixeira, Evandro Luis de Oliveira Niero, Camila Lauand, Glaucia Maria Machado-Santelli
Clinical data published in recent years has demonstrated positive effects of collagen hydrolysate (CH) on skin aging clinical signs. CH use as food supplement has a long history; however, few studies have addressed the underlying purpose of CH on the cellular and molecular biology of skin cells that could elucidate clinical improvement findings. Wide diversity of characteristics has been reported for dermal fibroblasts derived from different body sites and it is unknown whether collagen peptides could modulate differently cells from chronological aged and photoaged skin areas...
September 14, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28900534/resveratrol-enriched-rice-attenuates-uvb-ros-induced-skin-aging-via-downregulation-of-inflammatory-cascades
#3
Lalita Subedi, Taek Hwan Lee, Hussain Mustatab Wahedi, So-Hyeon Baek, Sun Yeou Kim
The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28858391/pterocarpus-santalinus-l-regulated-ultraviolet-b-irradiation-induced-procollagen-reduction-and-matrix-metalloproteinases-expression-through-activation-of-tgf-%C3%AE-smad-and-inhibition-of-the-mapk-ap-1-pathway-in-normal-human-dermal-fibroblasts
#4
Wei Gao, Pei Lin, Eunson Hwang, Yushuai Wang, Zhengfei Yan, Hien T T Ngo, Tae-Hoo Yi
Ultraviolet light-induced reactive oxygen species (ROS) damage human skin and prematurely cause aging. A growing body of research is focusing on considering plants and plant-derived compounds as anti-photoaging therapeutic material. Pterocarpus santalinus L., as an Indian traditional medicine, possesses antidiabetic, anti-inflammatory and antioxidative effects. Here, we studied the anti-photoaging effects of ethanolic extract of P. santalinus L. heartwood (EPS) on ultraviolet radiation B (UVB)-irradiated normal human dermal fibroblasts (NHDFs)...
August 31, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28852829/pal-12-a-new-anti-aging-hexa-peptoid-inhibits-uvb-induced-photoaging-in-human-dermal-fibroblasts-and-3d-reconstructed-human-full-skin-model-keraskin-ft%C3%A2
#5
Daeun Song, Hyeonji Park, Su-Hyon Lee, Mi Jung Kim, Eun-Joo Kim, Kyung-Min Lim
Peptoids are a class of peptidomimetics whose pharmacological activities are widely investigated owing to their remarkable biological stability. However, the utilities of peptoids as cosmetic functional ingredients have not been fully explored. Here, we investigated anti-aging effects of PAL-12, a new hexa-peptoid, on UVB-induced photoaging in human dermal fibroblasts (HDFs) and a 3D reconstituted human full skin model, Keraskin-FT™. PAL-12 suppressed matrix metalloproteinase-1 (MMP-1) expression induced by UVB irradiation along with the attenuation of MMP-1 secretion as determined by ELISA assay...
August 29, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28810554/beneficial-effects-of-dried-pomegranate-juice-concentrated-powder-on-ultraviolet-b-induced-skin-photoaging-in-hairless-mice
#6
Su-Jin Kang, Beom-Rak Choi, Seung-Hee Kim, Hae-Yeon Yi, Hye-Rim Park, Chang-Hyun Song, Sae-Kwang Ku, Young-Joon Lee
The present study investigated the anti-aging effects of pomegranate juice concentrated powder (PCP) in hairless mice following 15 weeks of UVB irradiation (three times a week; 0.18 J/cm(2)). Skin moisturizing effects were evaluated through skin water, collagen type I and hyaluronan contents, as well as collagen type I and hyaluronan synthesis-related transcript levels. Wrinkle formation and edema scores (skin weights) were also assessed, along with skin matrix metalloproteinase (MMP)-1, MMP-9 and MMP-13 transcript levels...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810000/effect-of-a-blueberry-derived-antioxidant-matrix-on-infrared-a-induced-gene-expression-in-human-dermal-fibroblasts
#7
Susanne Grether-Beck, Jean Krutmann, Katherine Wilkens, Kasey D'Amato
<p>There is compelling evidence that Infrared A (IRA) from natural sunlight contributes to photoaging of human skin by inducing the expression of matrix metalloproteinase-1 (MMP-1) expression in human dermal fibroblasts. Corresponding mechanistic studies have shown that IRA does so by increasing the production of reactive oxygen species in irradiated cells. In the present study, we therefore asked if treatment of primary human skin fibroblasts with a blueberry-derived antioxidant matrix (BerrimatrixTM), which is employed as an active ingredient in commercially available skin care products that are topically applied, can prevent IRA-induced MMP-1 expression in these cells...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28793178/ultraviolet-and-infrared-induced-11-beta-hydroxysteroid-dehydrogenase-type-1-activating-skin-photoaging-is-inhibited-by-red-ginseng-extract-containing-high-concentration-of-ginsenoside-rg3-s
#8
Jin-Ju Nam, Ji-Eun Min, Min-Ho Son, Jin-Hwan Oh, Seunghyun Kang
BACKGROUND: Sun irradiation is one of major extrinsic stressors responsible for premature skin aging through activation and expression of 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive cortisone to active cortisol. The aim of this study was to evaluate the inhibitory effects of red ginseng extract containing high concentrations of ginsenoside Rg3 (S) (GERg3) on 11β-HSD1-induced skin photoaging. METHODS: To evaluate the inhibitory effects of GERg3 on ultraviolet- (UV) or infrared (IR)-induced skin photoaging, human dermal fibroblasts or a normal human 3D skin model was exposed to UV or an IR...
August 9, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28713942/ginsenoside-rc-protects-against-uvb%C3%A2-induced-photooxidative-damage-in-epidermal-keratinocytes
#9
Yuri Oh, Hye-Won Lim, Kwang Hark Park, Yu-Hua Huang, Ji-Young Yoon, Kyunghoon Kim, Chang-Jin Lim
Ginsenoside Rc (Rc) is a major ginsenoside isolated from Panax ginseng, and has exhibited pharmacological effects on skin cells. The present study aimed to investigate the putative skin‑protective properties of Rc, including its anti‑photoaging and barrier function‑protective effects, in human HaCaT keratinocytes exposed to UVB radiation. The protective properties of Rc were evaluated through the assessment of keratinocyte viability, reactive oxygen species (ROS) production, total glutathione (GSH) and superoxide dismutase (SOD) activity, caspase‑14, matrix metalloproteinase (MMP)‑2 and ‑9 activity, and MMP‑2, MMP‑9 and filament aggregating protein (filaggrin) expression following UVB irradiation...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28659037/myrcene-an-aromatic-volatile-compound-ameliorates-human-skin-extrinsic-aging-via-regulation-of-mmps-production
#10
Eunson Hwang, Hien T T Ngo, Bom Park, Seul-A Seo, Jung-Eun Yang, Tae-Hoo Yi
Myrcene is an aromatic volatile compound that is commercially well-known as a flavor ingredient in the food industry and a fragrance in the soap and detergent industry. Given the worldwide interest in natural antiphotoaging products, we investigated the protective effects of myrcene in UVB-irradiated human dermal fibroblasts (NHDFs). NHDFs were subjected to 144[Formula: see text]mJ/cm(2)of UVB irradiation. The expression of intracellular reactive oxygen species (ROS), matrix metalloproteinase-1 (MMP-1), MMP-3, interleukin-6 (IL-6), transforming growth factor (TGF-[Formula: see text]1) and type I procollagen were examined...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28599356/an-in-vitro-model-for-fibroblast-photoaging-comparing-single-and-repeated-uva-irradiations
#11
Wongnapa Nakyai, Aurasorn Saraphanchotiwitthaya, Celine Viennet, Philippe Humbert, Jarupa Viyoch
The current method for efficient evaluation of anti-photoaging compounds is an in vitro skin culture model using a single ultraviolet A (UVA) irradiation of fibroblasts. However, skin photoaging is caused by repeated exposure to UVA radiation. The objective of this study was to develop an appropriate model for in vitro skin photoaging by comparing the different effects of single (5 J/cm(2) ) and repeated exposures (5 J/cm(2) x 3 times) of fibroblasts to UVA irradiation. Our results demonstrated that a single and repeated exposure to UVA irradiation had different effects on fibroblasts...
June 9, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28595074/protective-effect-of-arthrospira-platensis-extracts-against-ultraviolet-b-induced-cellular-senescence-through-inhibition-of-dna-damage-and-matrix-metalloproteinase-1-expression-in-human-dermal-fibroblasts
#12
Jeong-Ju Lee, Ki Bbeum Kim, Jina Heo, Dae-Hyun Cho, Hee-Sik Kim, Song Hee Han, Kyu Joong Ahn, In-Sook An, Sungkwan An, Seunghee Bae
Ultraviolet (UV) light exposure causes skin photoaging, which is known to be preventable and controllable by application of UV-protective agents. In this study, we demonstrated, for the first time, that the extract of microalgae Arthrospira platensis has a reverse effect on UV-induced photodamage such as loss of cell viability, cellular senescence, DNA damage, and collagen destruction in dermal fibroblasts. Forty-eight extracts were prepared from the cell biomass by controlling culture light conditions, extract solvents, and disruption methods...
May 31, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28557373/pten-inhibits-replicative-senescence-induced-mmp-1-expression-by-regulating-nox4-mediated-ros-in-human-dermal-fibroblasts
#13
Eun-Mi Noh, Jeong-Mi Kim, On-Yu Hong, Hyun-Kyung Song, Jong-Suk Kim, Kang-Beom Kwon, Young-Rae Lee
The biological function of NADPH oxidase (NOX) is the generation of reactive oxygen species (ROS). ROS, primarily arising from oxidative cell metabolism, play a major role in both chronological ageing and photoageing. ROS in extrinsic and intrinsic skin ageing may be assumed to induce the expression of matrix metalloproteinases. NADPH oxidase is closely linked with phosphatidylinositol 3-OH kinase (PI3K) signalling. Protein kinase C (PKC), a downstream molecule of PI3K, is essential for superoxide generation by NADPH oxidase...
May 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28551094/a-synthetic-peptide-blocking-trpv1-activation-inhibits-uv-induced-skin-responses
#14
So Min Kang, Sangbum Han, Jang-Hee Oh, Young Mee Lee, Chi-Hyun Park, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
BACKGROUND: Transient receptor potential type 1 (TRPV1) can be activated by ultraviolet (UV) irradiation, and mediates UV-induced matrix metalloproteinase (MMP)-1 and proinflammatory cytokines in keratinocytes. Various chemicals and compounds targeting TRPV1 activation have been developed, but are not in clinical use mostly due to their safety issues. OBJECTIVE: We aimed to develop a novel TRPV1-targeting peptide to inhibit UV-induced responses in human skin. METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr(705), and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin...
May 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28524092/marine-fish-proteins-and-peptides-for-cosmeceuticals-a-review
#15
REVIEW
Jayachandran Venkatesan, Sukumaran Anil, Se-Kwon Kim, Min Suk Shim
Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The bioactive proteins and peptides derived from marine fish have gained enormous interest in nutraceutical, pharmaceutical, and cosmeceutical industries due to their broad spectrum of bioactivities, including antioxidant, antimicrobial, and anti-aging activities. Recently, the development of cosmeceuticals using marine fish-derived proteins and peptides obtained from chemical or enzymatical hydrolysis of fish processing by-products has increased rapidly owing to their activities in antioxidation and tissue regeneration...
May 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28503261/anti-photoaging-effects-of-angelica-acutiloba-root-ethanol-extract-in-human-dermal-fibroblasts
#16
Min Ah Park, Mi Ja Sim, Young Chul Kim
The effects that ultraviolet rays elicit on collagen synthesis and degradation are the most common causes of wrinkle formation and photo-aging in skin. The objectives of this study were to evaluate the effects of Angelica acutiloba root ethanol extract (AAEE) to promote collagen synthesis and inhibit collagen degradation in human dermal fibroblasts. By examining total polyphenol and flavonoid contents, electron donating ability, radical scavenging activity, and superoxide dismutase-like activity, we found that AAEE exhibited fairly good antioxidant activity...
April 2017: Toxicological Research
https://www.readbyqxmd.com/read/28387707/alleviation-of-ultraviolet-b-induced-photodamage-by-coffea-arabica-extract-in-human-skin-fibroblasts-and-hairless-mouse-skin
#17
Po-Yuan Wu, Chi-Chang Huang, Yin Chu, Ya-Han Huang, Ping Lin, Yu-Han Liu, Kuo-Ching Wen, Chien-Yih Lin, Mei-Chich Hsu, Hsiu-Mei Chiang
Coffea arabica extract (CAE) containing 48.3 ± 0.4 mg/g of chlorogenic acid and a trace amount of caffeic acid was found to alleviate photoaging activity in human skin fibroblasts. In this study, polyphenol-rich CAE was investigated for its antioxidant and antiinflammatory properties, as well as for its capability to alleviate ultraviolet B (UVB)-induced photodamage in BALB/c hairless mice. The results indicated that 500 μg/mL of CAE exhibited a reducing power of 94.7%, ferrous ion chelating activity of 46...
April 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28327532/a-combination-of-soybean-and-haematococcus-extract-alleviates-ultraviolet-b-induced-photoaging
#18
Jieun Shin, Jong-Eun Kim, Kum-Ju Pak, Jung Il Kang, Tae-Seok Kim, Sang-Yoon Lee, Ik-Hyun Yeo, Jung Han Yoon Park, Jong Hun Kim, Nam Joo Kang, Ki Won Lee
Soybean-derived isoflavones have been investigated for their preventative effects against UV-induced symptoms of skin damage including wrinkle formation and inflammation. Haematococcus pluvialis is a freshwater species of Chlorophyta that contains high concentrations of the natural carotenoid pigment astaxanthin. Astaxanthin is known to be involved in retinoic acid receptor (RAR) signaling and previously been associated with the inhibition of activator protein (AP)-1 dependent transcription. Based on previous studies, we hypothesized that a combination of soy extract (SE) and Haematococcus extract (HE) may prevent UVB-induced photoaging through specific signaling pathways, as measured by UVB-induced wrinkling on hairless mice skin and expression changes in human dermal fibroblasts (HDFs)...
March 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28301572/far-infrared-suppresses-skin-photoaging-in-ultraviolet-b-exposed-fibroblasts-and-hairless-mice
#19
Hui-Wen Chiu, Cheng-Hsien Chen, Yi-Jie Chen, Yung-Ho Hsu
Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to block the epidermal hyperproliferative response to UVB and may play a crucial role in preventing skin photoaging. In the present study, we investigated whether far-infrared (FIR) therapy can inhibit skin photoaging via UVB irradiation in NIH 3T3 mouse embryonic fibroblasts and SKH-1 hairless mice...
2017: PloS One
https://www.readbyqxmd.com/read/28250652/cosmeceutical-effects-of-galactomannan-fraction-from-arenga-pinnata-fruits-in-vitro
#20
Yanti, Madriena, Soegianto Ali
BACKGROUND: Cosmeceuticals refer to natural cosmetics with medical-like benefits due to their bioactive contents. Sugar palm fruit (Arenga pinnata) extract has been claimed for its anti-aging effect in vitro. However, its active compounds for cosmeceuticals is still unclear. OBJECTIVE: This study was aimed to extract galactomannan from A. pinnata fruits and test its efficacy for tyrosinase inhibition, antioxidant, and anti-photoaging activities in vitro. MATERIALS AND METHODS: Galactomannan from A...
January 2017: Pharmacognosy Research
keyword
keyword
39789
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"