keyword
MENU ▼
Read by QxMD icon Read
search

Matrix metalloproteinases photoaging

keyword
https://www.readbyqxmd.com/read/29755556/defensive-properties-of-ginsenoside-re-against-uv-b-induced-oxidative-stress-through-up-regulating-glutathione-and-superoxide-dismutase-in-hacat-keratinocytes
#1
Daehyun Shin, Hee Won Moon, Yuri Oh, Kyunghoon Kim, Dae-Duk Kim, Chang-Jin Lim
Ginseng is now used worldwide as a traditional Oriental medicine. Ginsenosides, also known as ginseng saponins, are responsible for most pharmacological efficacies of ginseng. This work aimed to assess the novel skin anti-photoaging potential of ginsenoside Re (Re), a protopanaxatriol-type ginsenoside, by analyzing reactive oxygen species (ROS), pro-matrix metalloproteinase-2 (proMMP-2) and -9 (proMMP-9), total glutathione (GSH), superoxide dismutase (SOD), and cellular viability in UV-B-irradiated HaCaT keratinocytes...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29748977/paeonol-extracted-from-paeonia-suffruticosa-andr-ameliorated-uvb-induced-skin-photoaging-via-dld-nrf2-are-and-mapk-ap-1-pathway
#2
ZhengWang Sun, Juan Du, Eunson Hwang, Tae-Hoo Yi
Paeonia suffruticosa Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects of PS on ultraviolet B (UVB)-induced photoaging. In this study, paeonol (PA) was detected the main compound in PS root. In vitro, PS and PA significantly inhibited UVB-induced phosphorylation of mitogen-activated protein kinase and activator protein 1 in keratinocytes, which consequently led to degradation of procollagen type I. On the other hand, PS and PA increased NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 expression, confirmed by greater nuclear accumulation of nuclear factor E2-releated factor 2 (Nrf2)...
May 10, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29705807/rapamycin-protects-skin-fibroblasts-from-ultraviolet-b-induced-photoaging-by-suppressing-the-production-of-reactive-oxygen-species
#3
Dengke Qin, Runjian Ren, Chuanlong Jia, Yongzhou Lu, Qingjian Yang, Liang Chen, Xinyuan Wu, Jingjing Zhu, Yu Guo, Ping Yang, Yiqun Zhou, Ningwen Zhu, Bo Bi, Tianyi Liu
BACKGROUND/AIMS: Ultraviolet B (UVB) irradiation alters multiple molecular pathways in the skin, thereby inducing skin photoaging. Murine dermal fibroblasts (MDFs) were subjected to a series of 4 sub-cytotoxic UVB doses (120 mJ/cm2), resulting in changes in cell shape, DNA damage, cell cycle arrest, extracellular matrix variations, reactive oxygen species (ROS) generation, and alterations in major intracellular antioxidant and cellular autophagy levels. Rapamycin (RAPA) is a new macrolide immunosuppressive agent that is primarily used in oncology, cardiology, and transplantation medicine and has been found to extend the lifespan of genetically heterogeneous mice...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29687366/molecular-modeling-of-non-covalent-binding-of-ligustrum-lucidum-secoiridoid-glucosides-to-ap-1-matrix-metalloproteinase-pathway-components
#4
Pathomwat Wongrattanakamon, Piyarat Nimmanpipug, Busaban Sirithunyalug, Wantida Chaiyana, Supat Jiranusornkul
Ligustrum lucidum secoiridoid glucosides have been demonstrated to treat various types of diseases such as inflammation, pain, hepatotoxicity and hyperlipidermic as well as tonic for liver and kidney. Matrix metalloproteinases (MMPs) play a key role upon the pathology of photoaging. The present computational study showed that among the six secoiridoid glucosides (ligustroside, lucidumoside A, lucidumoside C, neonuezhenide, oleoside dimethylester, and oleuropein), ligustroside and lucidumoside A competitively inhibit all MMP-1, MMP-3, and MMP-9 activities in the docking models...
April 23, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29658877/simulation-of-the-elastin-and-fibrillin-in-non-irradiated-or-uva-radiated-fibroblasts-and-direct-inhibition-of-elastase-or-matrix-metalloptoteinases-activity-by-nicotinamide-or-its-derivatives
#5
Neena Philips, Jovinna Chalensouk-Khaosaat, Salvador Gonzalez
Skin aging/photoaging is associated with altered the structure of collagen and elastin fibers, and increased activity of matrix metalloproteinases (MMP) and elastase. Nicotinamide and its derivatives, 2,6-dihydroxynicotinamide, 2,4,5,6-tetrahydroxynicotinamide, and 3-hydroxypicolinamide (collectively niacin derivatives) stimulate fibrillar collagen and heat shock proteins in dermal fibroblasts. The goal of this research was to extend the understanding of the anti-skin aging mechanism of these niacin derivatives through the stimulation of elastin (at the protein and promoter levels), fibrillin (1 and 2) in nonirradiated or ultraviolet (UVA) radiated dermal fibroblasts, and through the direct inhibition of MMP (1, 3, and 9) and elastase activities...
January 2018: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29619069/-piper-retrofractum-vahl-extract-as-a-ppar-%C3%AE-and-ampk-activator-suppresses-uvb-induced-photoaging-through-mitochondrial-biogenesis-and-mmps-inhibition-in-human-dermal-fibroblasts-and-hairless-mice
#6
Jungon Yun, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang
Photoaging occurs by UVB-irradiation and involves production of reactive oxygen species (ROS) and overexpression of matrix metalloproteinases (MMPs), leading to extracellular matrix damage. Piper retrofractum Vahl. is used as a traditional medicine for antiflatulence, expectorant, sedative, and anti-irritant; however, its antiphotoaging effect has not yet been studied. The current study investigated the antiphotoaging effect of standardized Piper retrofractum extract (PRE) on UVB-damaged human dermal fibroblasts and hairless mouse skin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29609010/artemisia-asiatica-ethanol-extract-exhibits-anti-photoaging-activity
#7
Deok Jeong, Jongsung Lee, Seong-Gu Jeong, Yo Han Hong, Sulgi Yoo, Sang Yun Han, Ji Hye Kim, Sunggyu Kim, Jin Sic Kim, Young Soo Chung, Jong-Hoon Kim, Young-Su Yi, Jae Youl Cho
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia asiatica Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies. AIM OF THE STUDY: In this study, traditionally known skin-protective activity of Artemisia asiatica Nakai was examined with its ethanol extract (Aa-EE) under various photoaging conditions using skin-originated cells, and the underlying mechanism was also examined using various types of cells...
March 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29597313/protective-effects-of-lsgygp-from-fish-skin-gelatin-hydrolysates-on-uvb-induced-mefs-by-regulation-of-oxidative-stress-and-matrix-metalloproteinase-activity
#8
Qingyu Ma, Qiuming Liu, Ling Yuan, Yongliang Zhuang
A previous study has shown that tilapia fish skin gelatin hydrolysates inhibited photoaging in vivo, and that, Leu-Ser-Gly-Tyr-Gly-Pro (LSGYGP) identified in the hydrolysate had a high hydroxyl radical scavenging activity. In this study, activities of LSGYGP were further evaluated using ultraviolet B (UVB)-induced mouse embryonic fibroblasts (MEFs). UVB irradiation significantly increased the intercellular reactive oxygen species (ROS) production and matrix metalloproteinases (MMPs) activities and decreased the content of collagen in MEFs...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29568864/protective-effect-of-curcumin-against-ultraviolet-a-irradiation%C3%A2-induced-photoaging-in-human-dermal-fibroblasts
#9
Xiaoming Liu, Ruizhi Zhang, Haixia Shi, Xiaobo Li, Yanhong Li, Ahmad Taha, Chunxing Xu
Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in skin, resulting in photoaging. Natural botanicals have gained considerable attention due to their beneficial protection against the harmful effects of UV irradiation. The present study aimed to evaluate the ability of curcumin (Cur) to protect human dermal fibroblasts (HDFs) against ultraviolet A (UVA)‑induced photoaging. HDFs were treated with 0‑10 µM Cur for 2 h and subsequently exposed to various intensities of UVA irradiation...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29499374/borago-officinalis-l-attenuates-uvb-induced-skin-photodamage-via-regulation-of-ap-1-and-nrf2-are-pathway-in-normal-human-dermal-fibroblasts-and-promotion-of-collagen-synthesis-in-hairless-mice
#10
Seul A Seo, Bom Park, Eunson Hwang, Sang-Yong Park, Tae-Hoo Yi
Ultraviolet B (UVB) irradiation is regarded as the main cause of skin photodamage. After exposure to UVB irradiation, collagen degradation is accelerated by upregulation of matrix metalloproteinases (MMPs), and collagen synthesis is decreased via downregulation of transforming growth factor (TGF)-β1 signaling. Borago officinalis L. (BO) is an annual herb with medicinal and culinary applications. Although BO has been demonstrated to have antioxidant and anti-inflammatory activities, its potential anti-photoaging effects have not been examined...
July 1, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29498767/dermal-fibroblasts-can-activate-matrix-metalloproteinase-1-independent-of-keratinocytes-via-plasmin-in-a-3d-collagen-model
#11
Aska Sonoki, Yuri Okano, Yuichiro Yoshitake
Photoaging of the skin is marked by obvious wrinkles and mainly depends on degradation of the extracellular matrix (ECM) in the dermis. Matrix metalloproteinase (MMP)-1 is one of the most important factors involved in degradation of the ECM; however, its mechanism of activation is not fully understood. It has been thought that MMP-1 is expressed by dermal fibroblasts as an inactive precursor protein that is activated by proteinases produced by keratinocytes in the epidermis. In this study, we constructed a 3D model of the dermis using collagen-embedded fibroblasts with or without ultraviolet (UV)-A exposure to mimic photoaging in the dermis...
March 2, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29484380/black-rice-oryza-sativa-l-extract-modulates-ultraviolet-induced-expression-of-matrix-metalloproteinases-and-procollagen-in-a-skin-cell-model
#12
Mira Han, Jung-Soo Bae, Jae-Jun Ban, Hee Soon Shin, Dong Hun Lee, Jin Ho Chung
Exposure of the skin to ultraviolet (UV) radiation causes extracellular matrix (ECM) collapse in the dermis, owing to an increase in matrix metalloproteinase (MMP) production in both the epidermis and dermis, and a decrease in type I collagen expression in the dermis. Recently, black rice (Oryza sativa L.) was reported to have a wide range of pharmacological effects in various settings. However, the effects of black rice extract (BRE) on UV‑irradiated skin cells have not yet been characterized. BRE treatment did not affect cell morphology and viability of HaCaT and human dermal fibroblasts (HDF)...
May 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29470423/3-5-6-7-8-3-4-heptamethoxyflavone-a-citrus-flavonoid-inhibits-collagenase-activity-and-induces-type-i-procollagen-synthesis-in-hdfn-cells
#13
Hong-Il Kim, Yong-Un Jeong, Jong-Hyeon Kim, Young-Jin Park
Citrus fruits contain various types of flavonoids with powerful anti-aging and photoprotective effects on the skin, and have thus been attracting attention as potential, efficacious skincare agents. Here, we aimed to investigate the chemical composition of Citrus unshiu and its protective effects on photoaging. We isolated and identified a bioactive compound, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), from C. unshiu peels using ethanol extraction and hexane fractionation. HMF inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29446095/orobanche-cernua-loefling-attenuates-ultraviolet-b-mediated-photoaging-in-human-dermal-fibroblasts
#14
Wei Gao, Yu-Shuai Wang, Zheng-Yi Qu, Eunson Hwang, Hien T T Ngo, Ying-Ping Wang, Jahyun Bae, Tae-Hoo Yi
UV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents has become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB-induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs)...
February 15, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29433674/protective-effect-of-dietary-alchemilla-mollis-on-uvb-irradiated-premature-skin-aging-through-regulation-of-transcription-factor-nfatc1-and-nrf2-are-pathways
#15
Eunson Hwang, Hien T T Ngo, Seul A Seo, Bom Park, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Alchemilla mollis (lady's mantle) is a common ingredient in skin care products. However, the protective mechanism of A. mollis against skin problems has not been elucidated. PURPOSE: This study was to investigate the effects of A. mollis ethanolic extract (AM) on UVB-irradiated normal human dermal fibroblasts (NHDF) and hairless mice. METHODS: The in vitro anti-photoaging effect of AM was performed in NHDFs. The antioxidant activities were assessed through DPPH, ABTS, and reactive oxygen species (ROS) assays...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29421853/antiphotoaging-effect-of-prunus-yeonesis-blossom-extract-via-inhibition-of-mapk-ap-1-and-regulation-of-the-tgf-%C3%AE-i-smad-and-nrf2-are-signaling-pathways
#16
Lu Li, Eunson Hwang, Hien T T Ngo, Pei Lin, Wei Gao, Ying Liu, Tae-Hoo Yi
Cherry blossoms have attracted attention as an ingredient with potential for use in skincare products. However, no skin photoaging-related research has been performed with this plant. In this study, cherry blossom extract (CBE) at 1, 10 and 100 μg mL-1 was investigated for its skin antiphotoaging effects in UVB-irradiated normal human dermal fibroblasts (NHDF) cells in vitro. Our results showed that CBE markedly increased type-I procollagen during UVB exposure via two pathways. Firstly, transcription activator protein-1 expression and MAP kinases were downregulated, consequently reducing the production of matrix metalloproteinase (MMP)-1 and MMP-3...
February 8, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29399294/topical-or-oral-treatment-of-peach-flower-extract-attenuates-uv-induced-epidermal-thickening-matrix-metalloproteinase-13-expression-and-pro-inflammatory-cytokine-production-in-hairless-mice-skin
#17
Chung Shil Kwak, Jiwon Yang, Chang-Yup Shin, Jin Ho Chung
BACKGROUND/OBJECTIVES: Ultraviolet radiation (UV) is a major cause of skin photoaging. Previous studies reported that ethanol extract (PET) of Prunus persica (L.) Batsch flowers (PPF, peach flowers) and its subfractions, particularly the ethylacetate (PEA) and n-butanol extracts (PBT), have potent antioxidant activity and attenuate the UV-induced matrix metalloproteinase (MMP) expression in human skin cells. In this study, we investigated the protective activity of PPF extract against UV-induced photoaging in a mouse model...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29382339/the-flavonoid-hesperidin-exerts-anti-photoaging-effect-by-downregulating-matrix-metalloproteinase-mmp-9-expression-via-mitogen-activated-protein-kinase-mapk-dependent-signaling-pathways
#18
Hee Jeong Lee, A-Rang Im, Su-Man Kim, Hyung-Sik Kang, Jae Dong Lee, Sungwook Chae
BACKGROUND: Hesperidin is a flavonoid with antioxidant, anti-inflammatory, and immune modulatory activities. Photoaging is a consequence of chronic exposure to the sun and ultraviolet (UV) radiation. This study was designed to evaluate the efficacy of hesperidin against photoaging of dorsal skin in hairless mice. METHODS: Hairless male mice (6-week-old) were divided into three groups (n = 7): control, UVB-treated vehicle, and UVB-treated hesperidin groups. UVB-irradiated mice from hesperidin group were orally administered 0...
January 30, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29353733/in-vitro-evaluation-of-antioxidant-anti-elastase-anti-collagenase-anti-hyaluronidase-activities-of-safranal-and-determination-of-its-sun-protection-factor-in-skin-photoaging
#19
Kumud Madan, Sanju Nanda
Safranal, a monoterpene aldehyde, is present as one of the main volatile constituents of Crocus sativus Linn. (saffron flowers). This volatile constituent not only contributes to the aroma of saffron but has been reported to possess antidiabetic, antiulcer, antiasthamatic, anticonvulsant, antidepressant, cardioprotective, anticancer and UV protective properties. Most of these therapeutic actions are contributed by its potential to quench reactive oxygen species (ROS). Antioxidant properties of phytoconstituents are now being explored for developing photoprotective skin formulations...
April 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29348726/photoaging-protective-effects-of-biogf1k-a-compound-k-rich-fraction-prepared-from-panax-ginseng
#20
Yo Han Hong, Donghyun Kim, Gibaeg Nam, Sulgi Yoo, Sang Yun Han, Seong-Gu Jeong, Eunji Kim, Deok Jeong, Keejung Yoon, Sunggyu Kim, Junseong Park, Jae Youl Cho
Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events. Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry...
January 2018: Journal of Ginseng Research
keyword
keyword
39789
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"